Mannen Taro 萬年太郎

Researcher Number	50535763
Other IDs	https://orcid.org/0000-0002-7227-8509
Affiliation (Current)	2025: 立命館大学, 生命科学部, 助教
Affiliation (based on the past Project Information) *help	2017 – 2025: 立命館大学, 生命科学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 43010:Molecular biology-related / Cell biology Except Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Medium-sized Section 90:Biomedical engineering and related fields
Keywords	Principal Investigator RNA結合タンパク質 / 核内構造体 / 液液相分離 / ncRNA / がん / 相分離 / 核内RNA顆粒 / プロテオミクス / 細胞核 / RNA複合体 … More / レーザーマイクロダイセクション / ダイセクション / 質量分析 / ガン細胞 / 近接依存性標識法 / 液-液相分離 / RNA顆粒 / タンパク質修飾 / RNAポリメラーゼ / 細胞 / DBC1 / ノンコーディングRNA … More Except Principal Investigator 天然変性蛋白質 / splicing isoform / UTX / ヒストン脱メチル化酵素 / 神経変性疾患 / 液固相転移 / FUS / 圧力 / 筋萎縮性側索硬化症 / 顕微ラマン法 / RNA結合タンパク質 / 凝集 / 液液相分離 / 液－液相分離 / アデノシン三リン酸 Less

腫瘍発症におけるヒストン修飾因子UTXの選択的スプライシング脱制御の役割の解明
- Principal Investigator
  
  世良康如
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo Women's Medical University
核内相分離構造体の骨格となるRNAと生理機能の解明Principal Investigator
- Principal Investigator
  
  萬年太郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Ritsumeikan University
疾患を引き起こす液ー液相分離環境を正常化する細胞内変換型分子の開発
- Principal Investigator
  
  穴田貴久
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kyushu University
タンパク質の液固相転移メカニズムの解明と創薬展開
- Principal Investigator
  
  北原亮
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Ritsumeikan University
Characterization of nuclear bodies built on RNAPrincipal Investigator
- Principal Investigator
  
  Mannen Taro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Ritsumeikan University
Characterization of DBC1 nuclear bodies built around RNAsPrincipal Investigator
- Principal Investigator
  
  Mannen Taro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Ritsumeikan University

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] 相分離生物学の全貌（現代化学増刊46)、執筆箇所：71.質量分析装置LC-MS/MS2020
- Author(s)
  白木　賢太郎編、一部執筆：萬年太郎
- Total Pages
  416
- Publisher
  東京化学同人
- ISBN
  9784807913466
- Data Source
  KAKENHI-PROJECT-20K06493
[Journal Article] ArcRNAs and the formation of nuclear bodies.2021
- Author(s)
  Shinichi Nakagawa, Tomohiro Yamazaki, Taro Mannen, Tetsuro Hirose
- Journal Title
  
  Mammalian Genome
  
  Volume: - Issue: 2 Pages: 382-401
- DOI
  10.1007/s00335-021-09881-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06479, KAKENHI-PUBLICLY-21H00253, KAKENHI-PLANNED-21H05276, KAKENHI-PROJECT-20H00448, KAKENHI-PROJECT-20K06493, KAKENHI-PROJECT-21K19246, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06279, KAKENHI-PLANNED-21H05274
[Journal Article] Distinct RNA polymerase transcripts direct the assembly of phase-separated DBC1 nuclear bodies in different cell lines2021
- Author(s)
  Mannen Taro、Goto Masato、Yoshizawa Takuya、Yamashita Akio、Hirose Tetsuro、Hayano Toshiya
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 32 Issue: 21
- DOI
  10.1091/mbc.e21-02-0081
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22601, KAKENHI-PUBLICLY-20H05377, KAKENHI-PLANNED-21H05276, KAKENHI-PROJECT-20H00448, KAKENHI-PROJECT-20H03438, KAKENHI-PROJECT-20K06493, KAKENHI-PROJECT-21K19413
[Journal Article] C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers2021
- Author(s)
  Nanaura Hitoki、Aiba Yuichiro、Nakanishi Mari、Shiota Tomo、Hibino Masaki、Kikuchi Sotaro、Nagata Riko、Morikawa Naritaka、Iguchi Naohiko、Kiriyama Takao、Nagamori Shushi、Sugie Kazuma、Saio Tomohide、Yoshizawa Takuya、Mori Eiichiro et al.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 5301-5301
- DOI
  10.1038/s41467-021-25560-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07978, KAKENHI-PROJECT-19K16060, KAKENHI-PROJECT-20K16583, KAKENHI-PROJECT-18H03984, KAKENHI-PROJECT-18H05229, KAKENHI-PROJECT-20H00327, KAKENHI-PROJECT-20H03199, KAKENHI-PROJECT-20K06493, KAKENHI-PROJECT-20K06527, KAKENHI-PROJECT-20K06569, KAKENHI-PROJECT-20K06579, KAKENHI-PROJECT-21K15032, KAKENHI-PROJECT-19KK0071, KAKENHI-PROJECT-22KJ0024, KAKENHI-PLANNED-20H05925, KAKENHI-PROJECT-19H05648
[Journal Article] RNase Sensitivity Screening for Nuclear Bodies with RNA Scaffolds in Mammalian Cells2017
- Author(s)
  Mannen, T. and Hirose, T.
- Journal Title
  
  Bio-protocol
  
  Volume: 7 Issue: 8
- DOI
  10.21769/bioprotoc.2232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15112, KAKENHI-PLANNED-26113002, KAKENHI-PROJECT-17H03630
[Presentation] 質量分析を用いたSam68核内構造体の機能解析2022
- Author(s)
  友近愛、後藤雅人、萬年太郎、山下暁朗、廣瀬哲郎、早野俊哉
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K06493
[Presentation] HeLa細胞においてRNAによって形成されるSam68核内構造体の機能解析2022
- Author(s)
  友近愛、後藤雅人、萬年太郎、山下暁朗、廣瀬哲郎、早野俊哉
- Organizer
  第95回日本生化学大会
- Data Source
  KAKENHI-PROJECT-20K06493
[Presentation] 近接依存性標識法を用いた相分離様DBC1核内構造体の機能解析2022
- Author(s)
  萬年太郎、山下暁朗、廣瀬哲郎、早野俊哉
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K06493
[Presentation] Characterization of Sam68 nuclear body built around RNA in HeLa cells2022
- Author(s)
  友近愛、後藤雅人、萬年太郎、山下暁朗、廣瀬哲郎、早野俊哉
- Organizer
  第23回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-20K06493
[Presentation] Characterization of the abnormal cross β polymer formed by ALS-linked FUS mutants2022
- Author(s)
  柳森美貴、萬年太郎、吉澤拓也、山下暁朗、早野俊哉
- Organizer
  第23回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-20K06493
[Presentation] Characterization of phase-separated DBC1 nuclear body using the proximity labelling approach2022
- Author(s)
  萬年太郎、山下暁朗、廣瀬哲郎、早野俊哉
- Organizer
  第23回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-20K06493
[Presentation] ALS型FUS変異体における異常クロスβポリマー形成機構の解明2022
- Author(s)
  柳森美貴、萬年太郎、吉澤拓也、山下暁朗、早野俊哉
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K06493
[Presentation] がん細胞で形成されるSam68核内構造体の構成因子の探索2021
- Author(s)
  後藤雅人、柳森美貴、早田美帆、寧韻詩、萬年太郎、山下暁朗、廣瀬哲郎、早野俊哉
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20K06493
[Presentation] HNRNPDのアイソフォームを用いたSam68核内構造体の新規構成因子の探索2021
- Author(s)
  友近愛、萬年太郎、山下暁朗、廣瀬哲朗、早野俊哉
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20K06493
[Presentation] Distinct RNA polymerase transcripts direct the assembly of phase-separated DBC1 nuclear bodies in different cell lines2021
- Author(s)
  Taro Mannen, Masato Goto, Takuya Yoshizawa, Akio Yamashita, Tetsuro Hirose, Toshiya Hayano
- Organizer
  第22回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-20K06493
[Presentation] 細胞種により異なるRNAポリメラーゼ転写産物が相分離を介してDBC1核内構造体を形成する2021
- Author(s)
  萬年太郎、後藤雅人、吉澤拓也、山下暁朗、廣瀬哲郎、早野俊哉
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20K06493
[Presentation] 相分離を介して形成されるDBC1核内RNA顆粒の機能解析2021
- Author(s)
  Taro Mannen, Masato Goto, Takuya Yoshizawa, Akio Yamashita, Tetsuro Hirose, and Toshiya Hayano
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K06493
[Presentation] がん細胞で形成されるSam68核内構造体の機能解析2020
- Author(s)
  後藤雅人、友近愛、早田美帆、寧韻詩、萬年太郎、山下暁朗、廣瀬哲郎、早野俊哉
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K06493
[Presentation] Characterization of DBC1 nuclear bodies built around RNAs in cancer cell line2020
- Author(s)
  Taro Mannen, Akio Yamashita, Tetsuro Hirose, Toshiya Hayano
- Organizer
  日本放射線影響学会　第63回大会
- Data Source
  KAKENHI-PROJECT-20K06493
[Presentation] LLPS様の相互作用を介して形成される核内RNA顆粒の機能解析2019
- Author(s)
  萬年太郎、山下暁朗、廣瀬哲郎、早野俊哉
- Organizer
  第4回LLPS研究会・ASUKA若手交流会2019
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] Characterization of Sam68 and DBC1 nuclear bodies built around RNAs in cancer cell line2019
- Author(s)
  Taro Mannen, Ayaka Wada, Yunshi Ning, Miku Nishiura, Miho Hayata, Akio Yamashita, Tetsuro Hirose, Toshiya Hayano
- Organizer
  The 20th Takeda Science Foundation Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] がん細胞で形成されるSam68核内構造体とDBC1核内構造体の機能解析2019
- Author(s)
  後藤雅人、岸田真実、西浦未来、早田美帆、萬年太郎、山下暁朗、廣瀬哲郎、早野俊哉
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] Analysis of protein-protein interactions within the DBC1 nuclear bodies built around RNAs in cancer cell line2019
- Author(s)
  萬年太郎、山下暁朗、廣瀬哲郎、早野俊哉
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] がん細胞で形成されるSam68核内構造体とDBC1核内構造体の生理機能の解析2019
- Author(s)
  後藤雅人、岸田真実、西浦未来、早田美帆、萬年太郎、早野俊哉
- Organizer
  稀少疾患カンファランス、国際稀少疾患シンホジウム2019
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] がん細胞で形成されるDBC1核内RNA顆粒のタンパク質相互作用解析2019
- Author(s)
  萬年太郎、山下暁朗、廣瀬哲郎、早野俊哉
- Organizer
  第21回日本RNA学会
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] がん細胞で形成されるDBC1核内RNA顆粒の機能解析2019
- Author(s)
  萬年　太郎、早野　俊哉
- Organizer
  稀少疾患カンファランス、国際稀少疾患シンホジウム2019
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] Analysis of protein-protein interactions within the Sam68 and DBC1 nuclear bodies built around RNAs in cancer cell line2019
- Author(s)
  Taro Mannen, Akio Yamashita, Tetsuro Hirose
- Organizer
  EMBO workshop~RNP network dynamics indevelopment and disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] がん細胞で形成される核内構造体の機能解析2019
- Author(s)
  萬年太郎
- Organizer
  第7回生命医科学科コロキウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] 特定のがん細胞で形成される新規核内RNA顆粒の構成因子の探索2018
- Author(s)
  萬年太郎、西浦未来、早田美帆、山下暁朗、廣瀬哲郎、早野俊哉
- Organizer
  第41回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] 核内RNA顆粒であるSam68構造体とDBC1構造体の機能解析2018
- Author(s)
  西浦未来、早田美帆、萬年太郎、山下暁朗、廣瀬哲郎、早野俊哉
- Organizer
  第41回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] 特定のがん細胞で形成される核内RNA顆粒のタンパク質相互作用解析2018
- Author(s)
  萬年太郎、和田彩花、寧韻詩、西浦未来、早田美帆、山下暁朗、廣瀬哲郎、早野俊哉
- Organizer
  第20回　日本RNA学会
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] Analysis of protein-protein interactions within the nuclear bodies built around RNAs in cancer cell line2018
- Author(s)
  Taro Mannen, Ayaka Wada, Yunshi Ning, Miku Nishiura, Miho Hayata, Akio Yamashita, Tetsuro Hirose, Toshiya Hayano
- Organizer
  The 2nd JAJ (Joint Australia-Japan/Japan-Australia Joint) RNA Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] 核内RNA顆粒であるSam68構造体とDBC1構造体の構成因子の探索2018
- Author(s)
  西浦未来、早田美帆、和田彩花、寧韻詩、萬年太郎、早野俊哉
- Organizer
  第4回　稀少疾患セミナー
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] Distinct RNA polymerase transcripts competitively function as scaffold of the DBC1 nuclear bodies in specific cancer cell lines2017
- Author(s)
  Taro Mannen, Seisuke Yamashita, Kozo Tomita, Naoki Goshima, Tetsuro Hirose
- Organizer
  第19回日本RNA学会
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] がん細胞でRNA顆粒が融合して核内構造体を形成するメカニズムの解明2017
- Author(s)
  萬年　太郎
- Organizer
  技術シーズ交流発表会
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] 特定のがん細胞でRNA顆粒が融合して核内構造体を形成するメカニズム2017
- Author(s)
  萬年　太郎
- Organizer
  第5回　生命医科学科コロキウム
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] 癌細胞種により、異なるRNAポリメラーゼ転写産物が競合的にDBC1核内構造体の足場となる2017
- Author(s)
  萬年太郎、山下征輔, 富田耕造, 五島直樹, 廣瀬哲郎
- Organizer
  RNAフロンティアミーティング2017
- Data Source
  KAKENHI-PROJECT-17K15112
[Presentation] The Sam68 nuclear body is composed of two RNase-sensitive substructures joined by the adaptor HNRNPL2017
- Author(s)
  Taro Mannen, Seisuke Yamashita, Kozo Tomita, Naoki Goshima, Tetsuro Hirose
- Organizer
  第３回稀少疾患セミナー
- Data Source
  KAKENHI-PROJECT-17K15112

1. 八谷如美 (30408075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 穴田貴久 (30398466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 田中賢 (00322850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 田岡万悟 (60271160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 丹羽達也 (50588530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 北原亮 (70512284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 加藤稔 (00241258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 北沢創一郎 (50779030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 世良康如 (40836532)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 松村浩由 (30324809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 本田浩章 (40245064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山崎智弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 山下暁朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 杉江和馬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 七浦仁紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 桐山敬生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 塩田智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 井口直彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mannen Taro 萬年 太郎

Research Projects

Research Products

Co-Researchers

腫瘍発症におけるヒストン修飾因子UTXの選択的スプライシング脱制御の役割の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

核内相分離構造体の骨格となるRNAと生理機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

疾患を引き起こす液ー液相分離環境を正常化する細胞内変換型分子の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

タンパク質の液固相転移メカニズムの解明と創薬展開

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterization of nuclear bodies built on RNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterization of DBC1 nuclear bodies built around RNAsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 相分離生物学の全貌（現代化学増刊46)、執筆箇所：71.質量分析装置LC-MS/MS2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] ArcRNAs and the formation of nuclear bodies.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct RNA polymerase transcripts direct the assembly of phase-separated DBC1 nuclear bodies in different cell lines2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RNase Sensitivity Screening for Nuclear Bodies with RNA Scaffolds in Mammalian Cells2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] 質量分析を用いたSam68核内構造体の機能解析2022

Author(s)

Organizer

Data Source

[Presentation] HeLa細胞においてRNAによって形成されるSam68核内構造体の機能解析2022

Author(s)

Organizer

Data Source

[Presentation] 近接依存性標識法を用いた相分離様DBC1核内構造体の機能解析2022

Author(s)

Organizer

Data Source

[Presentation] Characterization of Sam68 nuclear body built around RNA in HeLa cells2022

Author(s)

Mannen Taro 萬年太郎