SHIRASAKI Takayoshi 白崎尚芳

Researcher Number	50547180
Other IDs
Affiliation (based on the past Project Information) *help	2013 – 2018: 金沢大学, 保健学系, 助教
Review Section/Research Field	Principal Investigator Virology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator 癌 / 感染症 / ウイルス / IFNλ4 / 感染防御・制御 / 肝臓学 / 自然免疫 / 慢性肝炎 / C型肝炎ウイルス Except Principal Investigator ウイルス … More / 感染症 / ウィルス / 発現制御 / 遺伝子 / 癌 / 自然免疫 / 幹細胞マーカー / ウイルス培養細胞 Less

Molecular mechanisms and biological, clinical significance of IFNL4Principal Investigator
- Principal Investigator
  
  Shirasaki Takayoshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Kanazawa University
Elucidation of the mechanisms of HBV infection using single cell transcriptome analysis
- Principal Investigator
  
  HONDA Masao
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University
Establishment new HCC derived cell lines that support efficient hepatitis virus replication.
- Principal Investigator
  
  HONDA Masao
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University
Elucidation of the mechanisms of non-response to antiviral treatment in chronic hepatitis CPrincipal Investigator
- Principal Investigator
  
  SHIRASAKI Takayoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Kanazawa University

All 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Peretinoin, an Acyclic Retinoid, Inhibits Hepatitis B Virus Replication by Suppressing Sphingosine Metabolic Pathway In Vitro.2018
- Author(s)
  1.Murai K, Shirasaki T, Honda M, Shimizu R, Shimakami T, Nakasho S, Shirasaki N, Okada H, Sakai Y, Yamashita T, Kaneko S.
- Journal Title
  
  International Journal of Molecular Sciences.
  
  Volume: 19(2) Issue: 2 Pages: 108-108
- DOI
  10.3390/ijms19020108
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-15K08492, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-16H04695
[Journal Article] Unexpected Replication Boost by Simeprevir for Simeprevir-resistant Variants in Genotype 1a Hepatitis C Virus2018
- Author(s)
  Murai K, Shimakami T, Welsch C, Shirasaki T, Liu F, Kitabayashi J, Tanaka S, Funaki M, Omura H, Nishikawa T, Suminyadorj A, Honda M, Kaneko S.
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 印刷中 Issue: 7
- DOI
  10.1128/aac.02601-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08492, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K21058
[Journal Article] The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication.2018
- Author(s)
  Shirasaki T, Honda M, Yamashita T, Nio K, Shimakami T, Shimizu R, Nakasyo S, Murai K, Shirasaki N, Okada H, Sakai Y, Sato T, Suzuki T, Yoshioka K, Kaneko S.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 13143-13143
- DOI
  10.1038/s41598-018-31421-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-18K19538, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02661, KAKENHI-PROJECT-18H02792, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K08579, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-16H04695
[Journal Article] Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.2017
- Author(s)
  Funaki M, Kitabayashi J, Shimakami T, Nagata N, Sakai Y, Takegoshi K, Okada H, Murai K, Shirasaki T, Oyama T, Yamashita T, Ota T, Takuwa Y, Honda M, Kaneko S.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 16978-16978
- DOI
  10.1038/s41598-017-17285-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04673, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15K08492
[Journal Article] A Novel mTOR Inhibitor; Anthracimycin for the Treatment of Human Hepatocellular Carcinoma.2017
- Author(s)
  Hayashi T, Yamashita T, Okada H, Oishi N, Sunagozaka H, Nio K, Hayashi T, Hara Y, Asahina Y, Yoshida M, Hashiba T, Suda T, Shirasaki T, Igarashi Y, Miyanouchi K, Yamashita T, Honda M, Kaneko S.
- Journal Title
  
  Anticancer Res
  
  Volume: 37 Pages: 3397-3403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K21058
[Journal Article] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet2017
- Author(s)
  Okada H, Takabatake R, Honda M, Takegoshi K, Yamashita T, Nakamura M, Shirasaki T, Sakai Y, Shimakami T, Nagata N, Takamura T, Tanaka T, Kaneko S.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 25 Pages: 39978-39993
- DOI
  10.18632/oncotarget.18116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-15H04809
[Journal Article] Reactivation of hepatitis B virus from an isolated anti-HBc positive patient after eradication of hepatitis C virus with direct-acting antiviral agents2017
- Author(s)
  Suda Tsuyoshi、Shimakami Tetsuro、Shirasaki Takayoshi、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi
- Journal Title
  
  J Hepatol
  
  Volume: 67 Issue: 5 Pages: 1108-1111
- DOI
  10.1016/j.jhep.2017.07.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-15K08492
[Journal Article] Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.2017
- Author(s)
  Tajima-Shirasaki N, Ishii KA, Takayama H, Shirasaki T, Iwama H, Chikamoto K, Saito Y, Iwasaki Y, Teraguchi A, Lan F, Kikuchi A, Takeshita Y, Murao K, Matsugo S, Kaneko S, Misu H, Takamura T.
- Journal Title
  
  J Biol Chem.
  
  Volume: 292 Issue: 26 Pages: 10791-10800
- DOI
  10.1074/jbc.m116.747006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-16K21058, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-17H03821
[Journal Article] Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model.2017
- Author(s)
  K Takegoshi, M Honda, H Okada, R Takabatake, N Matsuzawa-Nagata, JS Campbell, M Nishikawa, T Shimakami, T Shirasaki, Y Sakai, T Yamashita, T Takamura, T Tanaka, S Kaneko.
- Journal Title
  
  Oncotarget
  
  Volume: 印刷中 Issue: 11 Pages: 18191-18205
- DOI
  10.18632/oncotarget.15304
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26460995, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-16K21058
[Journal Article] Induction of IFN-lambda3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection2016
- Author(s)
  Murata, K. Asano, M. Matsumoto, A. Sugiyama, M. Nishida, N. Tanaka, E. Inoue, T. Sakamoto, M. Enomoto, N. Shirasaki, T. Honda, M. Kaneko, S. Gatanaga, H. Oka, S. Kawamura, Y. I. Dohi, T. Shuno, Y. Yano, H. Mizokami, M.
- Journal Title
  
  Gut
  
  Volume: - Issue: 2 Pages: 362-371
- DOI
  10.1136/gutjnl-2016-312653
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04503, KAKENHI-PROJECT-26461027, KAKENHI-PROJECT-15K08995, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-17K09448
[Journal Article] Efficient Suppression of Hepatitis C Virus Replication by Combination Treatment with miR-122 Antagonism and Direct-acting Antivirals in Cell Culture Systems.2016
- Author(s)
  Liu F, Shimakami T, Murai K, Shirasaki T, Funaki M, Honda M, Murakami S, Yi M, Tang H, Kaneko S.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 30939-30939
- DOI
  10.1038/srep30939
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-15K08492, KAKENHI-PROJECT-16K21058
[Journal Article] Hepatitis B Virus (HBV) Core-Related Antigen During Nucleos(t)ide Analog Therapy Is Related to Intra-hepatic HBV Replication and Development of Hepatocellular Carcinoma.2016
- Author(s)
  Honda M, Shirasaki T, Terashima T, Kawaguchi K, Nakamura M, Oishi N, Wang X, Shimakami T, Okada H, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.
- Journal Title
  
  Journal of Infectious Diseases
  
  Volume: 1;213(7) Pages: 1096-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870265
[Journal Article] Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver Cancer.2016
- Author(s)
  Kawaguchi K, Honda M, Yamashita T, Okada H, Shirasaki T, Nishikawa M, Nio K, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.
- Journal Title
  
  Am J Pathol.
  
  Volume: 186(8) Issue: 8 Pages: 2055-2067
- DOI
  10.1016/j.ajpath.2016.04.011
- NAID
  120005899105
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26460995, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-16K21058
[Journal Article] Hepatitis B Virus (HBV) Core-Related Antigen During Nucleos(t)ide Analog Therapy Is Related to Intra-hepatic HBV Replication and Development of Hepatocellular Carcinoma.2016
- Author(s)
  Honda M, Shirasaki T, Terashima T, Kawaguchi K, Nakamura M, Oishi N, Wang X, Shimakami T, Okada H, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.
- Journal Title
  
  J Infect Dis
  
  Volume: 213 Issue: 7 Pages: 1096-1106
- DOI
  10.1093/infdis/jiv572
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460995, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H06827, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-16K21058
[Journal Article] Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C.2015
- Author(s)
  Selitsky S, Gale J, Honda M, Yamane D, Masaki T, Fannin E, Guerra B, Shirasaki T, Shimakami T, Kaneko S, Lanford R, Lemon SM, Sethupathy P
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Pages: 7675-7675
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25870265
[Journal Article] Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice.2015
- Author(s)
  Okada H, Honda M, Campbell JS, Takegoshi K, Sakai Y, Yamashita T, Shirasaki T, Takabatake R, Nakamura M, Tanaka T, Kaneko S.
- Journal Title
  
  Cancer Science
  
  Volume: 106(9) Pages: 1143-52
- NAID
  120005830608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870265
[Journal Article] Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C.2015
- Author(s)
  Selitsky SR, Baran-Gale J, Honda M, Yamane D, Masaki T, Fannin EE, Guerra B, Shirasaki T, Shimakami T, Kaneko S, Lanford RE, Lemon SM, Sethupathy P.
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Issue: 1 Pages: 7675-7675
- DOI
  10.1038/srep07675
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24790687, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378
[Journal Article] Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice.2015
- Author(s)
  H Okada, M Honda, JS Campbell, K Takegoshi, Y Sakai, T Yamashita, T Shirasaki, R Takabatake, M Nakamura, T Tanaka, S Kaneko.
- Journal Title
  
  Cancer Sci
  
  Volume: 106 Issue: 9 Pages: 1143-1152
- DOI
  10.1111/cas.12730
- NAID
  120005830608
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378
[Journal Article] The Acyclic Retinoid Peretinoin Inhibits Hepatitis C Virus Replication and Infectious Virus Release in Vitro.2014
- Author(s)
  Shimakami T, Honda M, Shirasaki T, Takabatake R, Liu F, Murai K, Shiomoto T, Funaki M, Yamane D, Murakami S, Lemon SM, Kaneko S
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Pages: 4688-4688
- NAID
  120005774911
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25870265
[Journal Article] Metformin Suppresses Expression of the Selenoprotein P Gene via an AMP-activated Kinase (AMPK)/FoxO3a Pathway in H4IIEC3 Hepatocytes.2014
- Author(s)
  Takayama H, Misu H, Iwama H, Chikamoto K, Saito Y, Murao K, Teraguchi A, Lan F, Kikuchi A, Saito R, Tajima N, Shirasaki T, Matsugo S, Miyamoto K, Kaneko S, Takamura T
- Journal Title
  
  The Journal Of Biological Chemistry
  
  Volume: 289 (1) Pages: 335-345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870265
[Journal Article] Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin 28B genotypes2014
- Author(s)
  M Honda, T Shirasaki, T Shimakami, A Sakai, R Horii, K Arai, T Yamashita, Y Sakai, T Yamashita, H Okada, K Murai, M Nakamura, E Mizukoshi, S Kaneko
- Journal Title
  
  Hepatology
  
  Volume: 59(3) Issue: 3 Pages: 828-38
- DOI
  10.1002/hep.26788
- NAID
  120005447749
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-26670378
[Journal Article] Impaired IFN signaling in chronic hepatitis C patients with advanced fibrosis via the TGF-β signaling pathway2014
- Author(s)
  Shirasaki T, Honda M, Shimakami T, Murai K, Shiomoto T, Okada H, Takabatake R, Tokumaru A, Sakai Y, Yamashita T, Lemon SM, Murakami S, Kaneko S
- Journal Title
  
  Hepatology
  
  Volume: 60 (5) Pages: 1519-1530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870265
[Journal Article] Impaired interferon signaling in chronic hepatitis C patients with advanced fibrosis via the transforming growth factor beta signaling pathway.2014
- Author(s)
  Shirasaki T, Honda M, Shimakami T, Murai K, Shiomoto T, Okada H, Takabatake R, Tokumaru A, Sakai Y, Yamashita T, Lemon SM, Murakami S, Kaneko S.
- Journal Title
  
  Hepatology.
  
  Volume: 60(5) Issue: 5 Pages: 1519-30
- DOI
  10.1002/hep.27277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24790687, KAKENHI-PROJECT-26670378
[Journal Article] Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin 28B genotypes.2014
- Author(s)
  Honda M, Shirasaki T, Shimakami T, Sakai A, Horii R, Arai K, Yamashita T, Sakai Y, Yamashita T, Okada H, Murai K, Nakamura M, Mizukoshi E, Kaneko S
- Journal Title
  
  Hepatology
  
  Volume: 59 (3) Pages: 828-838
- NAID
  120005447749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870265
[Journal Article] The acyclic retinoid peretinoin inhibits hepatitis C virus replication and infectious virus release in vitro.2014
- Author(s)
  Shimakami T, Honda M, Shirasaki T, Takabatake R, Liu F, Murai K, Shiomoto T, Funaki M, Yamane D, Murakami S, Lemon SM, Kaneko S.
- Journal Title
  
  Sci Rep.
  
  Volume: 4 Issue: 1 Pages: 4688-4688
- DOI
  10.1038/srep04688
- NAID
  120005774911
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24790687, KAKENHI-PROJECT-26670378
[Journal Article] MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells.2013
- Author(s)
  Shirasaki T, Honda M, Shimakami T, Horii R, Yamashita T, Sakai Y, Sakai A, Okada H, Watanabe R, Murakami S, Yi M, Lemon SM, Kaneko S
- Journal Title
  
  Journal of Virology
  
  Volume: 87 (9) Pages: 5270-5286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870265
[Presentation] A liver-derived secretory protein, LECT2, restores the impaired plasmacytoid dendritic cells function by HBV and protects hepatocytes against HBV infection.2018
- Author(s)
  Takayoshi Shirasaki, Masao Honda, Tetsuro Shimakami, Kazunori Kawaguchi, Ying-Yi Li, Kouki Nio, Taro Yamashita, Shuichi Kaneko
- Organizer
  2018 International HBV Meeting Molecular Biology of Hepatitis B Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21058
[Presentation] A liver-derived secretory protein, LECT2, enhances the innate immune response and suppresses RIG-I mediated virus infection.2018
- Author(s)
  Takayoshi Shirasaki, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Hirofumi Misu, Toshinari Takamura, Shuichi Kaneko
- Organizer
  69th AASLD The Liver Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21058
[Presentation] A liver-derived secretory protein, LECT2, activates plasmacytoid dendritic cells and protects hepatocytes from HBV infection2017
- Author(s)
  Takayoshi Shirasaki, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Miwako Narita, Hirofumi Misu, Toshinari Takamura, Seishi Murakami, Shuichi Kaneko
- Organizer
  68th AASLD The Liver Meeting
- Data Source
  KAKENHI-PROJECT-16K21058
[Presentation] Differential microRNA expression in the liver during the advanced stage of chronic hepatitis C2017
- Author(s)
  Takayoshi Shirasaki, Masao Honda, Rika Horii, Tetsuro Shimakami, Kazuhisa Murai, Ryogo Shimizu, Shuichi Kaneko
- Organizer
  24th International Symposium on Hepatitis C virus and Related Viruses
- Data Source
  KAKENHI-PROJECT-16K21058
[Presentation] A liver-derived secretory protein, LECT2, activates plasmacytoid dendritic cells and protects hepatocytes from HBV infection2017
- Author(s)
  Takayoshi Shirasaki, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Ryogo Shimizu, Hirofumi Misu, Toshinari Takamura, Shuichi Kaneko
- Organizer
  2017 International HBV Meeting Molecular Biology of Hepatitis B Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21058
[Presentation] A liver-derived secretory protein, LECT2, enhances the innate immune response and suppresses HCV replication2017
- Author(s)
  Takayoshi Shirasaki
- Organizer
  5th Annual Meeting of the International Cytokine and Interferon Society, ICIS 2017
- Data Source
  KAKENHI-PROJECT-16K21058
[Presentation] A liver-derived secretory protein, LECT2, enhances the innate immune response and suppresses HCV replication2016
- Author(s)
  Takayoshi Shirasaki, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Hirofumi Misu, Toshinari Takamura, Seishi Murakami, Shuichi Kaneko
- Organizer
  67th AASLD The Liver Meeting
- Place of Presentation
  Boston (米国)
- Year and Date
  2016-11-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21058
[Presentation] A liver-derived secretory protein, LECT2, activates pDCs and protects hepatocytes against HBV infection.2016
- Author(s)
  Takayoshi Shirasaki, Masao Honda, Kazuhisa Murai, Miwako Narita, Hirofumi Misu, Toshinari Takamura, Seishi Murakami, Shuichi Kaneko
- Organizer
  67th AASLD The Liver Meeting
- Place of Presentation
  Boston (米国)
- Year and Date
  2016-11-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21058
[Presentation] A liver-derived secretory protein, LECT2, enhances the innate immune response and suppresses HCV replication.2016
- Author(s)
  Takayoshi Shirasaki, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Hirofumi Misu, Toshinari Takamura, Seishi Murakami, Shuichi Kaneko
- Organizer
  23rd International Symposium on Hepatitis C virus and Related Viruses
- Place of Presentation
  Kyoto (Japan)
- Year and Date
  2016-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21058
[Presentation] Effective prevention of direct-acting antiviral-resistant hepatitis C virus by combination with LNA-anti-miR-122 therapy in cell culture2015
- Author(s)
  Fanwei Liu, Tetsuro Shimakami, Kazuhisa Murai, Takayuki Shirasaki, Masaya Funaki, Masao Honda, Hong Tang, Seishi Murakami, Shuichi Kaneko
- Organizer
  22nd International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  ストラスブール（フランス）
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670378
[Presentation] LECT2 specifically induced by IL28B enhances the innate immune response and HCV replication2015
- Author(s)
  Takayoshi Shirasaki, Masao Honda, Tetsuro Shimakami, Kazuhisa Murai, Hirofumi Misu, Toshinari Takamura, Stanley Lemon, Seishi Murakami, Shuichi Kaneko
- Organizer
  22nd International Symposium on Hepatitis C virus and Related Viruses
- Place of Presentation
  Strasbourg, France
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25870265
[Presentation] LECT2 specifically induced by IL28B enhances the innate immune response and HCV replication2015
- Author(s)
  Takayoshi Shirasaki, Masao Honda, Tetsuro Shimakami, Kazuhisa Murai, Hirofumi Misu, Toshinari Takamura, Stanley Lemon, Seishi Murakami, Shuichi Kaneko
- Organizer
  66th AASLD The Liver Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25870265
[Presentation] LECT2 Specifically Induced by IL28B Regulates Interferon Response and HCV Replication.2014
- Author(s)
  Shirasaki T, Honda M, Shimakami T, Murai K, Shiomoto T, Misu H, Takamura T, Lemon SM, Murakami S, Kaneko S.
- Organizer
  21st International Symposium on Hepatitis C Viruses (HCV2014)
- Place of Presentation
  バンフ（カナダ）
- Year and Date
  2014-09-09
- Data Source
  KAKENHI-PROJECT-26670378
[Presentation] A secretory protein specifically induced by IL28B regulates interferon response2013
- Author(s)
  Takayoshi Shirasaki, Masao Honda, Tetsuro Shimakami, Kazuhisa Murai, Takayuki Shiomoto, Seishi Murakami, Shuichi Kaneko
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド　他　（兵庫県）
- Data Source
  KAKENHI-PROJECT-25870265
[Presentation] Impaired IFN signaling in chronic hepatitis C with advanced fibrosis via the TGF-β signaling pathway2013
- Author(s)
  Takayoshi Shirasaki, Masao Honda, Tetsuro Shimakami, Kazuhisa Murai, Takayuki Shiomoto, Hikari Okada, Riuta Takabatake, Stanley M Lemon, Seishi Murakami, Shuichi Kaneko
- Organizer
  20th International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Melbourne Convention and Exhibition Center (Australia)
- Data Source
  KAKENHI-PROJECT-25870265
[Presentation] Impaired IFN signaling in chronic hepatitis C with advanced fibrosis via the TGF-β signaling pathway2013
- Author(s)
  Takayoshi Shirasaki, Masao Honda, Tetsuro Shimakami, Kazuhisa Murai, Takayuki Shiomoto, Hikari Okada, Riuta Takabatake, Stanley M Lemon, Seishi Murakami, Shuichi Kaneko
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Disease
- Place of Presentation
  Walter E. Washington Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-25870265
[Presentation] LECT2 Specifically Induced by IL28B Regulates Interferon Response and HCV Replication
- Author(s)
  Shirasaki T, Honda M, Shimakami T, Murai K, Shiomoto T, Misu H, Takamura T, Lemon SM, Murakami S, Kaneko S
- Organizer
  21st International Symposium on Hepatitis C Viruses and Related Viruses
- Place of Presentation
  The Fairmont Banff Springs (Canada)
- Year and Date
  2014-09-07 – 2014-09-11
- Data Source
  KAKENHI-PROJECT-25870265
[Presentation] LECT2 Specifically Induced by IL28B Regulates Interferon Response and HCV Replication
- Author(s)
  Shirasaki T, Honda M, Shimakami T, Murai K, Shiomoto T, Misu H, Takamura T, Lemon SM, Murakami S, Kaneko S
- Organizer
  65th Annual Meeting of the American Association for the Study of Liver Disease
- Place of Presentation
  Hynes Veterans Memorial Convention Center (USA)
- Year and Date
  2014-11-07 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-25870265

1. HONDA Masao (00272980)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. YAMASHITA Taro (90377432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. SHIMAKAMI Tetsuro (50436820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. KAWAGUCHI Kazunori (90579632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 橋本真一 (00313099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Oishi Naoki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KAWAMURA Yuki I

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. TAKAMURA Toshinari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 土肥多恵子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 酒井佳夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
11. 金子周一

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. 岡田光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 竹下有美枝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIRASAKI Takayoshi 白崎 尚芳

Research Projects

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Molecular mechanisms and biological, clinical significance of IFNL4Principal Investigator

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Elucidation of the mechanisms of HBV infection using single cell transcriptome analysis

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Establishment new HCC derived cell lines that support efficient hepatitis virus replication.

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Elucidation of the mechanisms of non-response to antiviral treatment in chronic hepatitis CPrincipal Investigator

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[Journal Article] Peretinoin, an Acyclic Retinoid, Inhibits Hepatitis B Virus Replication by Suppressing Sphingosine Metabolic Pathway In Vitro.2018

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[Journal Article] Unexpected Replication Boost by Simeprevir for Simeprevir-resistant Variants in Genotype 1a Hepatitis C Virus2018

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[Journal Article] The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication.2018

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[Journal Article] Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.2017

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[Journal Article] A Novel mTOR Inhibitor; Anthracimycin for the Treatment of Human Hepatocellular Carcinoma.2017

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[Journal Article] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet2017

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[Journal Article] Reactivation of hepatitis B virus from an isolated anti-HBc positive patient after eradication of hepatitis C virus with direct-acting antiviral agents2017

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[Journal Article] Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.2017

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[Journal Article] Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model.2017

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[Journal Article] Induction of IFN-lambda3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection2016

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[Journal Article] Efficient Suppression of Hepatitis C Virus Replication by Combination Treatment with miR-122 Antagonism and Direct-acting Antivirals in Cell Culture Systems.2016

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SHIRASAKI Takayoshi 白崎尚芳