Kawabata Hidemasa 河端秀賢

Researcher Number	50548691
Other IDs
Affiliation (Current)	2025: 旭川医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 旭川医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related Except Principal Investigator Medium-sized Section 53:Organ-based internal medicine and related fields
Keywords	Principal Investigator 膵癌 / KRAS / GNAS / IPMN / GNAS変異 / 膵管内乳頭粘液性腫瘍 / Notchシグナル / 膵臓癌 Except Principal Investigator 早期診断 / 分子サブタイプ … More / cell-of-origin / IPMN / 前駆病変 / クローン進化 / 膵癌 Less

GNAS・KRASのクロストークによる膵癌進展機序解明と治療標的の探索Principal Investigator
- Principal Investigator
  
  河端秀賢
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
Strategy for an early diagnosis by modeling the developmental and evolutionary paths of human pancreatic cancer
- Principal Investigator
  
  水上裕輔
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Asahikawa Medical College
Exploration of biomarkers and therapeutic targets for pancreatic ductal papillary mucinous tumor-associated pancreatic cancer from the GNAS pathwayPrincipal Investigator
- Principal Investigator
  
  Kawabata Hidemasa
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College

All 2024 2023 2022

All Journal Article Presentation Book

[Book] 膵癌・胆道癌2023　上　膵癌編2023
- Author(s)
  河端秀賢
- Total Pages
  13
- Publisher
  日本臨床　増刊号
- Data Source
  KAKENHI-PROJECT-20K17009
[Book] 膵癌・胆道癌 2023 (上) 膵癌編 ―基礎・臨床の最新研究動向― II.各論2023
- Author(s)
  河端秀賢、高橋賢治、水上裕輔．
- Total Pages
  99
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-22KK0125
[Book] 膵癌・胆道癌 2023 (上) 膵癌編 ―基礎・臨床の最新研究動向― II.各論 81巻増刊号22023
- Author(s)
  河端秀賢、高橋賢治、水上裕輔
- Publisher
  日本臨牀
- Data Source
  KAKENHI-PROJECT-20K17009
[Journal Article] Liquid Biopsy for Pancreatic Cancer by Serum Extracellular Vesicle-Encapsulated Long Noncoding RNA HEVEPA.2024
- Author(s)
  Takahashi K, Inuzuka T, Shimizu Y, Sawamoto K, Taniue K, Ono Y, Asai F, Koyama K, Sato H, Kawabata H, Iwamoto H, Yamakita K, Kitano Y, Teramoto T, Fujiya M, Fujii S, Mizukami Y, Okumura T.
- Journal Title
  
  Pancreas.
  
  Volume: - Issue: 5 Pages: 395-404
- DOI
  10.1097/mpa.0000000000002315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21KK0283, KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-23K06759, KAKENHI-PROJECT-23K07389, KAKENHI-PROJECT-21K07954
[Journal Article] Multiplex Digital PCR Assay to Detect Multiple KRAS and GNAS Mutations Associated with Pancreatic Carcinogenesis from Minimal Specimen Amounts2023
- Author(s)
  Maeda Chiho、Ono Yusuke、Hayashi Akihiro、Takahashi Kenji、Taniue Kenzui、Kakisaka Rika、Mori Miyuki、Ishii Takahiro、Sato Hiroki、Okada Tetsuhiro、Kawabata Hidemasa、Goto Takuma、Tamamura Nobue、Omori Yuko、Takahashi Kuniyuki、Katanuma Akio、Karasaki Hidenori、Liss Andrew Scott、Mizukami Yusuke
- Journal Title
  
  The Journal of Molecular Diagnostics
  
  Volume: 23 Issue: 6 Pages: 1525-1578
- DOI
  10.1016/j.jmoldx.2023.02.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07954, KAKENHI-PROJECT-21KK0283, KAKENHI-PROJECT-20H03655, KAKENHI-PROJECT-20K07671, KAKENHI-PROJECT-19K17480, KAKENHI-PROJECT-21K20855, KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-23K06759, KAKENHI-PROJECT-22K16010, KAKENHI-PROJECT-21H02758
[Journal Article] Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway2022
- Author(s)
  Kawabata Hidemasa、Ono Yusuke、Tamamura Nobue、Oyama Kyohei、Ueda Jun、Sato Hiroki、Takahashi Kenji、Taniue Kenzui、Okada Tetsuhiro、Fujibayashi Syugo、Hayashi Akihiro、ほか
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 57 Issue: 3 Pages: 208-220
- DOI
  10.1007/s00535-021-01846-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16947, KAKENHI-PUBLICLY-20H04896, KAKENHI-PROJECT-19K07261, KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-21K07954, KAKENHI-PROJECT-20K17009, KAKENHI-PROJECT-21KK0283, KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-19H03448, KAKENHI-PROJECT-20H03655, KAKENHI-PROJECT-20K07671, KAKENHI-PROJECT-20K09070, KAKENHI-PROJECT-19K17480, KAKENHI-PROJECT-19K06452, KAKENHI-PROJECT-21H02758
[Presentation] IPMN関連膵癌におけるGNAS遺伝子の病態解明からみた治療戦略2023
- Author(s)
  河端秀賢
- Organizer
  第54回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-20K17009
[Presentation] High-sensitive liquid biopsy using pancreatic juice/duodenal fluid containing tumor-derived DNA to capture genetic mutations by molecular barcode sequencing.2023
- Author(s)
  Yusuke Ono, Kenji Takahashi, Chiho Maeda, Akihiro Hayashi, Hidemasa Kawabata, Tetsuhiro Okada, Hiroki Sato, Atsushi Saito, Toru Kawamoto, Kuniyuki Takahashi, Keisuke Kimura, Hirotoshi Iwano, Nobuyuki Yanagawa, Mayumi Suzuki, Miyuki Mori, Hidenori Karasaki, Yusuke Mizukami.
- Organizer
  UEGW 112th Annual Meeting. Abstract session.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] IPMN関連膵癌における変異型GNASによる腫瘍悪性度の制御2023
- Author(s)
  河端秀賢
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-20K17009
[Presentation] IPMN関連膵癌における変異型GNASによる腫瘍悪性度の制御.2023
- Author(s)
  河端秀賢、高橋賢治、水上裕輔.
- Organizer
  第109回日本消化器病学会総会. シンポジウム 6:消化器がん分子標的・免疫療法の新展開.
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] Circulating extracellular vesicle-encapsulated long non-coding RNAs obtained via liquid biopsy are potential biomarkers for pancreatic ductal adenocarcinoma.2023
- Author(s)
  Kenji Takahashi, Tatsutosi Inuzuka, Fumi Asai, Kazuya Koyama, Mami Kajiura, Hiroki Sato, Tetsuhiro Okada,Hidemasa Kawabata, Hidetaka Iwamoto, Yohei Kitano, Mikihiro Fujiya, Yusuke Mizukami, Toshikatsu Okumura.
- Organizer
  UEGW 112th Annual Meeting. Moderated Posters.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] GNAS変異はKRAS経路に拮抗することにより、膵癌の悪性度を抑える.2022
- Author(s)
  Hidemasa Kawabata, Yusuke Ono, Kenji Takahashi, Kenzui Taniue, Hidenori Karasaki, Yusuke Mizukami.
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway.2022
- Author(s)
  Hidemasa Kawabata
- Organizer
  第26回国際膵臓学会　Oral 27 IPMN(Basic Research)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17009
[Presentation] TUMOR-SUPPRESSIVE EFFECT OF MUTANT GNAS THROUGH THE RESTRICTION OF TUMOR AGGRESSIVENESS IN ESTABLISHED PANCREATIC CANCER2022
- Author(s)
  Hidemasa Kawabata
- Organizer
  DDW2022, Digestive disease week, Sandiego
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17009
[Presentation] IPMN関連膵癌におけるPKA-GNAS経路による悪性度制御.2022
- Author(s)
  河端秀賢
- Organizer
  第7回 Gastro-PLUS　口頭発表
- Data Source
  KAKENHI-PROJECT-20K17009
[Presentation] The application of EV RNA panel as liquid biopsy for pancreatic ductal adenocarcinoma.2022
- Author(s)
  Takahashi K, Sato H, Fujibayashi S, Hayashi A, Kawabata H, Iwamoto H, Goto T, Kitano Y, Mizukami Y, Okumura T.
- Organizer
  第26回国際膵臓学会 Symposium 5 Molecular profiling of pancreatic cancer and application of liquid biopsy to clinical practice
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] 細胞外小胞によるmiR-425の細胞間伝達は上皮間葉形質転換を促進し膵癌進展を制御する.2022
- Author(s)
  小山一也、高橋賢治、藤林周吾、林　明宏、河端秀賢、岩本英孝、後藤拓磨、北野陽平、藤谷幹浩、水上裕輔、奥村利勝.
- Organizer
  第30回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] Tumor-suppressive effect of mutant GNAS through the restriction of tumor aggressiveness in established pancreatic cancer.2022
- Author(s)
  Hidemasa Kawabata
- Organizer
  DDW2022/AGA2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17009
[Presentation] Tumor-suppressive effect of mutant GNAS through the restriction of tumor aggressiveness in established pancreatic cancer.2022
- Author(s)
  Kawabata H, Ono Y, Tamamura N, Sato H, Takahashi K, Taniue K, Okada T, Fujibayashi S, Hayashi A, Goto T, Konishi H, Fujiya M, Karasaki H, Liss AS, Mizukami Y, Okumura T.
- Organizer
  DDW2022/AGA2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0125

1. 水上裕輔 (30400089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. 高橋賢治 (00736332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. 小野裕介 (40742648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 谷上賢瑞 (90648627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 林明宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 佐藤裕基

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawabata Hidemasa 河端 秀賢

Research Projects

Research Products

Co-Researchers

GNAS・KRASのクロストークによる膵癌進展機序解明と治療標的の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Strategy for an early diagnosis by modeling the developmental and evolutionary paths of human pancreatic cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of biomarkers and therapeutic targets for pancreatic ductal papillary mucinous tumor-associated pancreatic cancer from the GNAS pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 膵癌・胆道癌2023 上 膵癌編2023

Author(s)

Total Pages

Publisher

Data Source

[Book] 膵癌・胆道癌 2023 (上) 膵癌編 ―基礎・臨床の最新研究動向― II.各 論2023

Author(s)

Total Pages

Publisher

Data Source

[Book] 膵癌・胆道癌 2023 (上) 膵癌編 ―基礎・臨床の最新研究動向― II.各 論 81巻 増刊号22023

Author(s)

Publisher

Data Source

[Journal Article] Liquid Biopsy for Pancreatic Cancer by Serum Extracellular Vesicle-Encapsulated Long Noncoding RNA HEVEPA.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multiplex Digital PCR Assay to Detect Multiple KRAS and GNAS Mutations Associated with Pancreatic Carcinogenesis from Minimal Specimen Amounts2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] IPMN関連膵癌におけるGNAS遺伝子の病態解明からみた治療戦略2023

Author(s)

Organizer

Data Source

[Presentation] High-sensitive liquid biopsy using pancreatic juice/duodenal fluid containing tumor-derived DNA to capture genetic mutations by molecular barcode sequencing.2023

Author(s)

Organizer

Data Source

[Presentation] IPMN関連膵癌における変異型GNASによる腫瘍悪性度の制御2023

Author(s)

Organizer

Data Source

[Presentation] IPMN関連膵癌における変異型GNASによる腫瘍悪性度の制御.2023

Author(s)

Organizer

Data Source

[Presentation] Circulating extracellular vesicle-encapsulated long non-coding RNAs obtained via liquid biopsy are potential biomarkers for pancreatic ductal adenocarcinoma.2023

Author(s)

Organizer

Data Source

[Presentation] GNAS変異はKRAS経路に拮抗することにより、膵癌の悪性度を抑える.2022

Author(s)

Organizer

Data Source

[Presentation] Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway.2022

Author(s)

Organizer

Data Source

[Presentation] TUMOR-SUPPRESSIVE EFFECT OF MUTANT GNAS THROUGH THE RESTRICTION OF TUMOR AGGRESSIVENESS IN ESTABLISHED PANCREATIC CANCER2022

Kawabata Hidemasa 河端秀賢

[Book] 膵癌・胆道癌2023　上　膵癌編2023

[Book] 膵癌・胆道癌 2023 (上) 膵癌編 ―基礎・臨床の最新研究動向― II.各論2023

[Book] 膵癌・胆道癌 2023 (上) 膵癌編 ―基礎・臨床の最新研究動向― II.各論 81巻増刊号22023