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Kimura Ayuko  木村 鮎子

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KIMURA Ayuko  木村 鮎子

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Researcher Number 50553616
Other IDs
Affiliation (Current) 2022: 群馬パース大学, 医療技術学部, 講師
Affiliation (based on the past Project Information) *help 2020 – 2021: 群馬パース大学, 保健科学部, 講師
2018: 群馬パース大学, 保健科学部, 講師
2017: 横浜市立大学, 先端医科学研究センター, 特任助教
2013 – 2016: 横浜市立大学, 生命医科学研究科, 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 49010:Pathological biochemistry-related / Functional biochemistry / Pathological medical chemistry
Keywords
Principal Investigator
プロテオミクス / プロテアソーム / ユビキチン / 翻訳後修飾 / ユビキチン化 / 癌 / ミリストイル化 / Rpt2 / 核 / 細胞内局在 … More / リン酸化 / 悪性化 / クロマチン再構成複合体 / 卵巣明細胞癌 / 悪性度 / SWI/SNF複合体 / Brg1 / OCCC / 老化 / N-ミリストイル化 / ストレス応答 Less
  • Research Projects

    (4 results)
  • Research Products

    (21 results)
  • Co-Researchers

    (18 People)
  •  Analysis of cell aging mechanisms through posttranslational modification-induced downregulation of proteasome activityPrincipal Investigator

    • Principal Investigator
      木村 鮎子
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Gunma Paz University
  •  N-myristoylation-induced nuclear localization of proteasome and stress response in tumor microenvironmentPrincipal Investigator

    • Principal Investigator
      Kimura Ayuko
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Gunma Paz University
  •  Phosphorylation of SWI/SNF chromatin remodeling component Brg1 and mechanisms involved in malignant transformation of cancerPrincipal Investigator

    • Principal Investigator
      KIMURA Ayuko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Yokohama City University
  •  Functions of the nuclear ubiquitin proteasome system regulated by N-myristoylationPrincipal Investigator

    • Principal Investigator
      KIMURA Ayuko
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      Yokohama City University

All 2018 2017 2016 2015 2014 2013

All Journal Article Presentation Book

  • [Book] In silico創薬におけるスクリーニングの高速化・効率化技術2018

    • Author(s)
      木村 鮎子
    • Total Pages
      540
    • Publisher
      技術情報協会
    • Data Source
      KAKENHI-PROJECT-18K06966
  • [Book] In silico創薬におけるスクリーニングの高速化・効率化技術, 6章 システムバイオロジーによる疾患研究およびバイオマーカー探索の具体的事例, 第2節 プロテオミクスによる疾病研究とバイオマーカー探索2018

    • Author(s)
      木村 鮎子 (分担執筆)
    • Total Pages
      540
    • Publisher
      技術情報協会
    • ISBN
      9784861046889
    • Data Source
      KAKENHI-PROJECT-15K19028
  • [Book] 医学のあゆみ 9章. 「疾患研究における翻訳後修飾の解析」2014

    • Author(s)
      木村 鮎子、平野 久
    • Total Pages
      1034
    • Publisher
      医歯薬出版
    • Data Source
      KAKENHI-PROJECT-25840039
  • [Journal Article] Serum quantitative proteomic analysis reveals soluble EGFR to be a marker of insulin resistance in male mice and humans2017

    • Author(s)
      Kyohara M, Shirakawa J, Okuyama T, Kimura A, Togashi Y, Tajima K, Hirano H, Terauchi Y.
    • Journal Title

      Endocrinology

      Volume: 158(12) Pages: 4152-4164

    • DOI

      10.1210/en.2017-00339

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-15K19028
  • [Journal Article] 癌悪性化機構の解明を目指したリン酸化プロテオーム解析2017

    • Author(s)
      木村 鮎子、平野 久
    • Journal Title

      Proteome Letters

      Volume: 2 Pages: 37-45

    • NAID

      130007529343

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19028
  • [Journal Article] Lyn Kinase Suppresses the transcriptional activity of IRF5 in the TLR-MyD88 pathway to restrain the development of autoimmunity2016

    • Author(s)
      Ban T., Sato G.R., Nishiyama A., Akiyama A., Takasuna M., Umehara M., Suzuki S., Ichino M., Matsunaga S., Kimura A., Kimura Y., Yanai H., Miyashita S., Kuromitsu J., Tsukahara K., Yoshimatsu K., Endo I., Yamamoto T., Hirano H., Ryo A., Taniguchi T., Tamura T.
    • Journal Title

      Immunity

      Volume: 45 Pages: 319-32

    • DOI

      10.1016/j.immuni.2016.07.015

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-16H07105, KAKENHI-PROJECT-26460373, KAKENHI-PROJECT-15K19028, KAKENHI-PROJECT-16K19161, KAKENHI-PROJECT-16H05230, KAKENHI-PLANNED-24118002
  • [Journal Article] Biological significance of co- and post-translational modifications of the yeast 26S proteasome2016

    • Author(s)
      Hirano H, Kimura Y, Kimura A
    • Journal Title

      Journal of Proteomics

      Volume: 134 Pages: 37-46

    • DOI

      10.1016/j.jprot.2015.11.016

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K19028, KAKENHI-PROJECT-16H05230
  • [Journal Article] N-myristoylation of the Rpt2 subunit of the yeast 26S proteasome is implicated in the subcellular compartment-specific protein quality control system2016

    • Author(s)
      Kimura A, Kurata Y, Nakabayashi J, Kagawa H, Hirano H.
    • Journal Title

      Journal of Proteomics

      Volume: 130 Pages: 33-41

    • DOI

      10.1016/j.jprot.2015.08.021

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K19028, KAKENHI-PROJECT-26830099
  • [Journal Article] Comprehensive behavioral study and proteomic analyses of CRMP2-deficient mice2016

    • Author(s)
      Nakamura H, Yamashita N, Kimura A, Kimura Y, Hirano H, Makihara H, Kawamoto Y, Jitsuki-Takahashi A, Yonezaki K, Takase K, Miyazaki T, Nakamura F, Tanaka F, Goshima Y.
    • Journal Title

      Genes to Cells

      Volume: 21 Pages: 1059-1079

    • DOI

      10.1111/gtc.12403

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19028, KAKENHI-PROJECT-16H05230
  • [Journal Article] Mass Spectrometric Analysis of the Phosphorylation Levels of the SWI/SNF Chromatin Remodeling/Tumor Suppressor Proteins ARID1A and Brg1 in Ovarian Clear Cell Adenocarcinoma Cell Lines.2014

    • Author(s)
      Kimura, A., Arakawa, N., and Hirano, H.
    • Journal Title

      Journal of Proteome Research

      Volume: 13(11) Pages: 4959-4969

    • DOI

      10.1021/pr500470h

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25460695, KAKENHI-PROJECT-25840039
  • [Presentation] プロテオミクスによる病態解析2018

    • Author(s)
      木村 鮎子
    • Organizer
      第26回 日本臨床化学会 関東支部総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K06966
  • [Presentation] クロマチン再構成複合体因子BRG1のリン酸化修飾によるクロマチン関連タンパク質の変化と遺伝子発現制御2017

    • Author(s)
      木村 鮎子、中林 潤、田村 智彦、香川 裕之、木村 弥生、平野 久
    • Organizer
      2017年度 生命科学系学会合同年次大会 (第40回 日本分子生物学会年会)
    • Data Source
      KAKENHI-PROJECT-15K19028
  • [Presentation] Proteome and transcriptome analyses of phosphorylation site-specific mutants of BRG1, a chromatin remodeling component2017

    • Author(s)
      Ayuko Kimura, Jun Nakabayashi, Tomohiko Tamura, Hiroyuki Kagawa, Yayoi Kimura, and Hisashi Hirano
    • Organizer
      16th Human Proteome Organization World Congress (HUPO2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19028
  • [Presentation] Effects of phosphorylation site-specific mutations in a component of chromatin remodeling complex2017

    • Author(s)
      Ayuko Kimura
    • Organizer
      日本プロテオーム学会2017年大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K19028
  • [Presentation] 癌悪性化機構の解明を目指したリン酸化プロテオーム解析2016

    • Author(s)
      木村 鮎子
    • Organizer
      日本プロテオーム学会2016年大会 (JHUPO第14回大会)
    • Place of Presentation
      北里大学
    • Year and Date
      2016-07-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K19028
  • [Presentation] (受賞講演)癌悪性化機構の解明を目指したリン酸化プロテオーム解析2016

    • Author(s)
      木村 鮎子
    • Organizer
      日本プロテオーム学会2016年大会(JHUPO第14回大会)
    • Place of Presentation
      北里大学白金キャンパス (東京都港区)
    • Year and Date
      2016-07-29
    • Data Source
      KAKENHI-PROJECT-15K19028
  • [Presentation] 卵巣明細胞腺癌の悪性化機構の解明を目指したリン酸化プロテオーム解析2016

    • Author(s)
      木村 鮎子
    • Organizer
      第13回 北里疾患プロテオーム研究会/第66回 日本電気泳動学会シンポジウム
    • Place of Presentation
      北里大学
    • Year and Date
      2016-03-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K19028
  • [Presentation] 酵母26SプロテアソームサブユニットのN-ミリストイル化修飾とタンパク質品質管理2015

    • Author(s)
      木村 鮎子、倉田 洋一、香川 裕之、平野 久
    • Organizer
      第38回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-03
    • Data Source
      KAKENHI-PROJECT-15K19028
  • [Presentation] MRM法による卵巣明細胞腺癌細胞株特異的なSWI/SNFクロマチン再構成複合体因子Brg1のリン酸化レベル低下の解析2014

    • Author(s)
      木村 鮎子, 荒川 憲昭, 平野 久
    • Organizer
      日本プロテオーム学会第12回大会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2014-07-18
    • Data Source
      KAKENHI-PROJECT-25840039
  • [Presentation] 卵巣明細胞腺癌細胞株特異的なクロマチン再構成因子Brg1のリン酸化レベル低下2014

    • Author(s)
      木村 鮎子, 荒川 憲昭, 平野 久
    • Organizer
      第37回 日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-26
    • Data Source
      KAKENHI-PROJECT-25840039
  • [Presentation] Identification and Characterization of the Posttranslational Modifications of Yeast 26S Proteasome2013

    • Author(s)
      Ayuko Kimura, Yu Kato, Yoichi Kurata, Yayoi Kimura, Hisashi Hirano
    • Organizer
      HUPO 12th Annual World Congress
    • Place of Presentation
      Pacifico Yokohama, Japan
    • Invited
    • Data Source
      KAKENHI-PROJECT-25840039
  • 1.  YANAI Hideyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  TAMURA Tomohiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 3.  NISHIYAMA Akira
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 4.  SATO Go
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  YAMAMOTO Junichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  SUZUKI Hidefumi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  BAN Tatsuma
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 8.  OSHIMA Takashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  谷口 維紹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  山本 一彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  松永 智子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  木村 弥生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 13.  荒川 憲昭
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  倉田 洋一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  寺内 康夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  白川 純
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  富樫 優
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  田島 一樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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