Kimura Ayuko 木村鮎子

… Alternative Names

Researcher Number	50553616
Other IDs
Affiliation (Current)	2022: 群馬パース大学, 医療技術学部, 講師
Affiliation (based on the past Project Information) *help	2022: 群馬パース大学, 医療技術学部, 講師 2020 – 2022: 群馬パース大学, 保健科学部, 講師 2018: 群馬パース大学, 保健科学部, 講師 2017: 横浜市立大学, 先端医科学研究センター, 特任助教 2013 – 2016: 横浜市立大学, 生命医科学研究科, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Functional biochemistry / Pathological medical chemistry Except Principal Investigator Basic Section 49050:Bacteriology-related / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator プロテオミクス / プロテアソーム / ユビキチン / 翻訳後修飾 / ユビキチン化 / 癌 / ミリストイル化 / Rpt2 / 核 / 細胞内局在 … More Except Principal Investigator 尿路感染症 / 薬剤耐性 / バイオフィルム / 病原性 / 情報伝達 / サイトカイン / 細胞性粘菌 / DIF誘導体 / 新規免疫制御剤 / セクリトーム解析 Less

細菌由来リスク因子に着目した尿路病原性大腸菌による腎盂腎炎発症と難治化機構の解明
- Principal Investigator
  
  平川秀忠
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Gunma University
免疫系培養細胞を用いたセクリトーム解析による新規生物活性物質の網羅的探索
- Principal Investigator
  
  高橋克典
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Gunma Paz University
Analysis of cell aging mechanisms through posttranslational modification-induced downregulation of proteasome activityPrincipal Investigator
- Principal Investigator
  
  木村鮎子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Gunma Paz University
N-myristoylation-induced nuclear localization of proteasome and stress response in tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  Kimura Ayuko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Gunma Paz University
Phosphorylation of SWI/SNF chromatin remodeling component Brg1 and mechanisms involved in malignant transformation of cancerPrincipal Investigator
- Principal Investigator
  
  KIMURA Ayuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Yokohama City University
Functions of the nuclear ubiquitin proteasome system regulated by N-myristoylationPrincipal Investigator
- Principal Investigator
  
  KIMURA Ayuko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Yokohama City University

All 2018 2017 2016 2015 2014 2013

All Journal Article Presentation Book

[Book] In silico創薬におけるスクリーニングの高速化・効率化技術2018
- Author(s)
  木村　鮎子
- Total Pages
  540
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-18K06966
[Book] In silico創薬におけるスクリーニングの高速化・効率化技術, 6章システムバイオロジーによる疾患研究およびバイオマーカー探索の具体的事例, 第2節プロテオミクスによる疾病研究とバイオマーカー探索2018
- Author(s)
  木村　鮎子 (分担執筆)
- Total Pages
  540
- Publisher
  技術情報協会
- ISBN
  9784861046889
- Data Source
  KAKENHI-PROJECT-15K19028
[Book] 医学のあゆみ 9章. 「疾患研究における翻訳後修飾の解析」2014
- Author(s)
  木村　鮎子、平野　久
- Total Pages
  1034
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-25840039
[Journal Article] Serum quantitative proteomic analysis reveals soluble EGFR to be a marker of insulin resistance in male mice and humans2017
- Author(s)
  Kyohara M, Shirakawa J, Okuyama T, Kimura A, Togashi Y, Tajima K, Hirano H, Terauchi Y.
- Journal Title
  
  Endocrinology
  
  Volume: 158(12) Pages: 4152-4164
- DOI
  10.1210/en.2017-00339
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-15K19028
[Journal Article] 癌悪性化機構の解明を目指したリン酸化プロテオーム解析2017
- Author(s)
  木村　鮎子、平野　久
- Journal Title
  
  Proteome Letters
  
  Volume: 2 Pages: 37-45
- NAID
  130007529343
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19028
[Journal Article] Lyn Kinase Suppresses the transcriptional activity of IRF5 in the TLR-MyD88 pathway to restrain the development of autoimmunity2016
- Author(s)
  Ban T., Sato G.R., Nishiyama A., Akiyama A., Takasuna M., Umehara M., Suzuki S., Ichino M., Matsunaga S., Kimura A., Kimura Y., Yanai H., Miyashita S., Kuromitsu J., Tsukahara K., Yoshimatsu K., Endo I., Yamamoto T., Hirano H., Ryo A., Taniguchi T., Tamura T.
- Journal Title
  
  Immunity
  
  Volume: 45 Pages: 319-32
- DOI
  10.1016/j.immuni.2016.07.015
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-16H07105, KAKENHI-PROJECT-26460373, KAKENHI-PROJECT-15K19028, KAKENHI-PROJECT-16K19161, KAKENHI-PROJECT-16H05230, KAKENHI-PLANNED-24118002
[Journal Article] Biological significance of co- and post-translational modifications of the yeast 26S proteasome2016
- Author(s)
  Hirano H, Kimura Y, Kimura A
- Journal Title
  
  Journal of Proteomics
  
  Volume: 134 Pages: 37-46
- DOI
  10.1016/j.jprot.2015.11.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19028, KAKENHI-PROJECT-16H05230
[Journal Article] N-myristoylation of the Rpt2 subunit of the yeast 26S proteasome is implicated in the subcellular compartment-specific protein quality control system2016
- Author(s)
  Kimura A, Kurata Y, Nakabayashi J, Kagawa H, Hirano H.
- Journal Title
  
  Journal of Proteomics
  
  Volume: 130 Pages: 33-41
- DOI
  10.1016/j.jprot.2015.08.021
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19028, KAKENHI-PROJECT-26830099
[Journal Article] Comprehensive behavioral study and proteomic analyses of CRMP2-deficient mice2016
- Author(s)
  Nakamura H, Yamashita N, Kimura A, Kimura Y, Hirano H, Makihara H, Kawamoto Y, Jitsuki-Takahashi A, Yonezaki K, Takase K, Miyazaki T, Nakamura F, Tanaka F, Goshima Y.
- Journal Title
  
  Genes to Cells
  
  Volume: 21 Pages: 1059-1079
- DOI
  10.1111/gtc.12403
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19028, KAKENHI-PROJECT-16H05230
[Journal Article] Mass Spectrometric Analysis of the Phosphorylation Levels of the SWI/SNF Chromatin Remodeling/Tumor Suppressor Proteins ARID1A and Brg1 in Ovarian Clear Cell Adenocarcinoma Cell Lines.2014
- Author(s)
  Kimura, A., Arakawa, N., and Hirano, H.
- Journal Title
  
  Journal of Proteome Research
  
  Volume: 13(11) Pages: 4959-4969
- DOI
  10.1021/pr500470h
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460695, KAKENHI-PROJECT-25840039
[Presentation] プロテオミクスによる病態解析2018
- Author(s)
  木村　鮎子
- Organizer
  第26回日本臨床化学会関東支部総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06966
[Presentation] クロマチン再構成複合体因子BRG1のリン酸化修飾によるクロマチン関連タンパク質の変化と遺伝子発現制御2017
- Author(s)
  木村鮎子、中林潤、田村智彦、香川裕之、木村弥生、平野久
- Organizer
  2017年度生命科学系学会合同年次大会 (第40回日本分子生物学会年会)
- Data Source
  KAKENHI-PROJECT-15K19028
[Presentation] Proteome and transcriptome analyses of phosphorylation site-specific mutants of BRG1, a chromatin remodeling component2017
- Author(s)
  Ayuko Kimura, Jun Nakabayashi, Tomohiko Tamura, Hiroyuki Kagawa, Yayoi Kimura, and Hisashi Hirano
- Organizer
  16th Human Proteome Organization World Congress (HUPO2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19028
[Presentation] Effects of phosphorylation site-specific mutations in a component of chromatin remodeling complex2017
- Author(s)
  Ayuko Kimura
- Organizer
  日本プロテオーム学会2017年大会
- Invited
- Data Source
  KAKENHI-PROJECT-15K19028
[Presentation] 癌悪性化機構の解明を目指したリン酸化プロテオーム解析2016
- Author(s)
  木村　鮎子
- Organizer
  日本プロテオーム学会2016年大会（JHUPO第14回大会）
- Place of Presentation
  北里大学
- Year and Date
  2016-07-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K19028
[Presentation] (受賞講演)癌悪性化機構の解明を目指したリン酸化プロテオーム解析2016
- Author(s)
  木村　鮎子
- Organizer
  日本プロテオーム学会2016年大会（JHUPO第14回大会）
- Place of Presentation
  北里大学白金キャンパス (東京都港区)
- Year and Date
  2016-07-29
- Data Source
  KAKENHI-PROJECT-15K19028
[Presentation] 卵巣明細胞腺癌の悪性化機構の解明を目指したリン酸化プロテオーム解析2016
- Author(s)
  木村　鮎子
- Organizer
  第13回　北里疾患プロテオーム研究会/第66回　日本電気泳動学会シンポジウム
- Place of Presentation
  北里大学
- Year and Date
  2016-03-25
- Invited
- Data Source
  KAKENHI-PROJECT-15K19028
[Presentation] 酵母26SプロテアソームサブユニットのN-ミリストイル化修飾とタンパク質品質管理2015
- Author(s)
  木村　鮎子、倉田　洋一、香川　裕之、平野　久
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15K19028
[Presentation] MRM法による卵巣明細胞腺癌細胞株特異的なSWI/SNFクロマチン再構成複合体因子Brg1のリン酸化レベル低下の解析2014
- Author(s)
  木村　鮎子, 荒川　憲昭, 平野　久
- Organizer
  日本プロテオーム学会第12回大会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2014-07-18
- Data Source
  KAKENHI-PROJECT-25840039
[Presentation] 卵巣明細胞腺癌細胞株特異的なクロマチン再構成因子Brg1のリン酸化レベル低下2014
- Author(s)
  木村　鮎子, 荒川　憲昭, 平野　久
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-25840039
[Presentation] Identification and Characterization of the Posttranslational Modifications of Yeast 26S Proteasome2013
- Author(s)
  Ayuko Kimura, Yu Kato, Yoichi Kurata, Yayoi Kimura, Hisashi Hirano
- Organizer
  HUPO 12th Annual World Congress
- Place of Presentation
  Pacifico Yokohama, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-25840039

1. 平川秀忠 (80431758)

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2. 鈴江一友 (00333485)

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3. 村上正巳 (30241871)

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4. 高橋克典 (90597551)

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5. 久保原禅 (00221937)

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6. 菊地晴久 (90302166)

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7. YANAI Hideyuki

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8. TAMURA Tomohiko

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# of Collaborated Products: 2 results
9. NISHIYAMA Akira

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10. SATO Go

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11. YAMAMOTO Junichi

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12. SUZUKI Hidefumi

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13. BAN Tatsuma

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14. OSHIMA Takashi

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15. 谷口維紹

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16. 山本一彦

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17. 松永智子

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18. 木村弥生

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19. 荒川憲昭

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20. 倉田洋一

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21. 寺内康夫

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22. 白川純

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23. 富樫優

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24. 田島一樹

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Kimura Ayuko 木村 鮎子

KIMURA Ayuko 木村 鮎子

Research Projects

Research Products

Co-Researchers

細菌由来リスク因子に着目した尿路病原性大腸菌による腎盂腎炎発症と難治化機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

免疫系培養細胞を用いたセクリトーム解析による新規生物活性物質の網羅的探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of cell aging mechanisms through posttranslational modification-induced downregulation of proteasome activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

N-myristoylation-induced nuclear localization of proteasome and stress response in tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Phosphorylation of SWI/SNF chromatin remodeling component Brg1 and mechanisms involved in malignant transformation of cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functions of the nuclear ubiquitin proteasome system regulated by N-myristoylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] In silico創薬におけるスクリーニングの高速化・効率化技術2018

Author(s)

Total Pages

Publisher

Data Source

[Book] In silico創薬におけるスクリーニングの高速化・効率化技術, 6章 システムバイオロジーによる疾患研究およびバイオマーカー探索の具体的事例, 第2節 プロテオミクスによる疾病研究とバイオマーカー探索2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 医学のあゆみ 9章. 「疾患研究における翻訳後修飾の解析」2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Serum quantitative proteomic analysis reveals soluble EGFR to be a marker of insulin resistance in male mice and humans2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 癌悪性化機構の解明を目指したリン酸化プロテオーム解析2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Lyn Kinase Suppresses the transcriptional activity of IRF5 in the TLR-MyD88 pathway to restrain the development of autoimmunity2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biological significance of co- and post-translational modifications of the yeast 26S proteasome2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] N-myristoylation of the Rpt2 subunit of the yeast 26S proteasome is implicated in the subcellular compartment-specific protein quality control system2016

Author(s)

Journal Title

Kimura Ayuko 木村鮎子

KIMURA Ayuko 木村鮎子

[Book] In silico創薬におけるスクリーニングの高速化・効率化技術, 6章システムバイオロジーによる疾患研究およびバイオマーカー探索の具体的事例, 第2節プロテオミクスによる疾病研究とバイオマーカー探索2018