Kubohara Yuzuru 久保原禅

… Alternative Names

KUBOHARA Yuzuru 久保原禅

久保原禅クボハラユズル

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Researcher Number	00221937
Other IDs
Affiliation (Current)	2025: 順天堂大学, スポーツ健康科学部, 客員教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 順天堂大学, 大学院スポーツ健康科学研究科, 教授 2015 – 2020: 順天堂大学, スポーツ健康科学研究科, 教授 2015: 順天堂大学, スポーツ健康科学部, 教授 2007 – 2014: Gunma University, 生体調節研究所, 准教授 2001 – 2006: 群馬大学, 生体調節研究所, 助教授 … More 2004: 群馬大学, 生体調整研究所, 助教授 1999: 群馬大, 生体調節研究所, 助手 1997 – 1998: 群馬大学, 生体調節研究所, 助手 1994 – 1995: 群馬大学, 生体調節研究所, 助手 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Biological pharmacy / 内分泌・代謝学 / Basic Section 38030:Applied biochemistry-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Pharmacology in pharmacy / Metabolomics / Cell biology Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Laboratory animal science … More / Applied health science / Mathematical Sciences in Search of New Cooperation / Medical pharmacy / Functional biochemistry Less
Keywords	Principal Investigator DIF / 糖尿病 / 細胞性粘菌 / がん / Dictyostelium / PDE1 / トリパノソーマ / 免疫 / calcium / 抗菌剤 … More / 抗がん剤 / 創薬 / K562 / Erk / 抗腫瘍因子 / DIF-1 / 走化性運動 / ミトコンドリア / 糖代謝 / 肥満 / 分化誘導因子 / anti-tumor agent / Dictyostelium discoideum / D. discoideum / 天然物化学 / マラリア / 抗菌薬 / 細胞分化 / 転移阻害剤 / Zinc / 亜鉛 / Cancer / Anti-tumor drug / 癌 / activin / pancreas / diabetes / differentiation / βcell / pancreatic stem cell / insulin / regeneration medicine / 幹細胞 / 分化誘導 / 膵β細胞 / 膵幹細胞 / インスリン / 再生医学 / 低分子化合物 / 抗腫瘍剤 / anti-tamor agent / Dictyostalium / PKB / Akt / P13-kinase / leukemia / HL-60 / AR42J / differentiation-inducing factor / Differentiation / Differentiation-inducing factor … More Except Principal Investigator 細胞性粘菌 / 一酸化窒素 / ニトロ化 / 酸化ストレス / DIF-1 / 新規免疫制御剤 / DIF誘導体 / IL-2 / サイトカイン / 合成化合物 / セクリトーム解析 / ６－ニトロトリプトファン / アトピー性皮膚炎 / アレルギー / 運動 / 微生物モニタリング / 日和見病原体 / 病原因子 / 細菌分類 / 全ゲノム / 食作用 / Esi / Cdi / Rodentibacter spp. / R. heylii / R. pneumotropicus / RTX毒素 / ドラフトゲノム / 肺パスツレラ / DIF / 炎症 / 肥満 / 高血糖 / 糖尿病 / 3-ニトロチロシン / 6-ニトロトリプトファン / 細胞運動 / 白血球遊走 / 走化性方程式 / Fokker-Planck方程式 / CFD解析 / PIV実験 / Navier-Stokes方程式 / Keller-Segel系 / Langevin方程式 / 流体型移流拡散方程式 / 拡散性 / 走化性 / Dictyopyrones / pharmacological specific target / growth inhibitory activity / leukemia cells / DIF-1 like factors / differentiation-inducing factor / cellular slime mold / ハロゲン化化合物 / キノコ / 4-methyl-5-n-propylbenzene-1,3-diol / Dictiostelium mucoroides / 増殖抑制 / DIF様因子 / dictyopyrones / 薬理学的ターゲット / 増殖阻害活性 / 白血病細胞 / DIF-1様因子 / 分化誘導因子 / Gab-1 / Src / チロシンリン酸化 / カドヘリン / 局在化 / 細胞間接着 / HGF / 増殖因子受容体 Less

細胞性粘菌由来化合物をリードとした新規肥満治療薬・糖尿病治療薬の開発Principal Investigator
- Principal Investigator
  
  久保原禅
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Juntendo University
免疫系培養細胞を用いたセクリトーム解析による新規生物活性物質の網羅的探索
- Principal Investigator
  
  高橋克典
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Gunma Paz University
Effects of moderate exercise on type I allergy
- Principal Investigator
  
  IIZUMI Kyoichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Shibata Gakuen University
Drug development using biologically active substances derived from D. discoideum as seedsPrincipal Investigator
- Principal Investigator
  
  Kubohara Yuzuru
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Juntendo University
Search for anti-diabetic agents based on protein nitration
- Principal Investigator
  
  IIZUMI Kyoichi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Tohoku Womens College
  Juntendo University
Reclassification of [Pasteurella] pneumotropica and detection of virulence determinants.
- Principal Investigator
  
  Sasaki Hiraku
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Juntendo University
Research on pharmacologically active molecule DIF found in the cellular slime mold Dictyostelium discoieumPrincipal Investigator
- Principal Investigator
  
  Kubohara Yuzuru
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Juntendo University
Mathematical modelling of diffusion-drift system of double chemotaxis type coupled with fluid
- Principal Investigator
  
  Sugiyama Yoshie
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Mathematical Sciences in Search of New Cooperation
- Research Institution
  Osaka University
  Kyushu University
Study on the bio-active molecule, DIF, found in the cellular slime mold Dictyostelium discoideumPrincipal Investigator
- Principal Investigator
  
  Kubohara Yuzuru
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Juntendo University
  Gunma University
Study on the bio-active molecule, DIF, found in the soil micro-organism Dictyostelium discoideumPrincipal Investigator
- Principal Investigator
  
  KUBOHARA Yuzuru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gunma University
Analysis of the mechanisms of the actions of DIF, a bio-active compound isolated from a soil micro-organism, and development of effective DIF derivativesPrincipal Investigator
- Principal Investigator
  
  KUBOHARA Yuzuru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Gunma University
Analysis of the mechanisms of the actions of DIF-1 and its derivatives, anti-tumor agents isolated from DictyosteliumPrincipal Investigator
- Principal Investigator
  
  KUBOHARA Yuzuru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Gunma University
Search for novel anti-tumor drugs and study on the action mechanism
- Principal Investigator
  
  HOSAKA Kohei
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Gunma University
Analysis of the actions and the action mechanism of DIF, an anti-tumor agent isolated from a soil microorganismPrincipal Investigator
- Principal Investigator
  
  KUBOHARA Yuzuru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Gunma University
増殖因子受容体の細胞接着部位特異的な局在化の分子機構
- Principal Investigator
  
  的崎尚
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Gunma University
Cell Biology of the Pancreatic Stem CellsPrincipal Investigator
- Principal Investigator
  
  KUBOHARA Yuzuru
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Institute for Molecular and Cellular Regulation, Gunma University
細胞性粘菌より単離された分化誘導因子DIFの抗腫瘍作用の解析Principal Investigator
- Principal Investigator
  
  久保原禅
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Gunma University
腫瘍細胞の再分化誘導因子の単離/同定と再分化機構の解析Principal Investigator
- Principal Investigator
  
  久保原禅
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Gunma University
腫瘍細胞の再分化誘導因子の単離/同定と再分化機構の解析Principal Investigator
- Principal Investigator
  
  久保原禅
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Gunma University

[Book] 細胞性粘菌（研究の新展開）～モデル生物、創薬資源、バイオ～2012
- Author(s)
  阿部知顕、前田靖男（編著）、久保原禅　他（著）
- Total Pages
  552
- Publisher
  アイピーシー社
- Data Source
  KAKENHI-PROJECT-24590110
[Book] 群馬に多い病気~生活習慣病を知り、克服する2007
- Author(s)
  小島至、久保原禅(他7名)、ブックレット群馬大学1
- Total Pages
  72
- Publisher
  上毛新聞社刊
- Data Source
  KAKENHI-PROJECT-19590136
[Journal Article] Isolation and Structure Determination of New Pyrones from Dictyostelium spp. Cellar Slime Molds Coincubated with Pseudomonas spp.2024
- Author(s)
  Nishimura T, Murotani T, Sasaki H, Uekusa Y, Eguchi H, Ishigaki H, Takahashi K, Kubohara Y, Kikuch H.
- Journal Title
  
  Molecules
  
  Volume: 29
- Data Source
  KAKENHI-PROJECT-22K11759
[Journal Article] Dictyostelium Differentiation-inducing Factor Derivatives Reduce the Glycosylation of PD-L1 in MDA-MB-231 Human Breast Cancer Cells2023
- Author(s)
 Airi Hirayama, Hirotaka Ishigaki, Katsunori Takahashi, Yusuke Miura, Haruhisa Kikuchi, Yuzuru Kubohara
- Journal Title
 
 Juntendo Medical Journal
 
 Volume: 69 Issue: 2 Pages: 105-115
- DOI
 10.14789/jmj.JMJ22-0039-OA
- ISSN
 2187-9737, 2188-2126
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-19K07139
[Journal Article] Dictyostelium Differentiation-Inducing Factor-1 Promotes Glucose Uptake, at Least in Part, via an AMPK-Dependent Pathway in Mouse 3T3-L1 Cells2021
- Author(s)
  Kubohara Yuzuru、Homma Yoshimi、Shibata Hiroshi、Oshima Yoshiteru、Kikuchi Haruhisa
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 5 Pages: 2293-2293
- DOI
  10.3390/ijms22052293
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07139
[Journal Article] Derivatives of Dictyostelium differentiation-inducing factors suppress the growth of Plasmodium parasites in vitro and in vivo.2021
- Author(s)
  Mita T, Hirai M, Maki Y, Nahar S, Yoshida N, Oshima Y, Kikuchi H, Kubohara Y.
- Journal Title
  
  Biochem Pharmacol
  
  Volume: - Pages: 114834-114834
- DOI
  10.1016/j.bcp.2021.114834
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04074, KAKENHI-PROJECT-18K07095, KAKENHI-PROJECT-19K07139, KAKENHI-PROJECT-20K07466
[Journal Article] 炎症性腸疾患の抑制に関わる分子の探索 ―動物モデルを用いた運動の効果―2021
- Author(s)
  飯泉恭一、重永綾子、都築孝允、川崎広明、山倉文幸、久保原禅
- Journal Title
  
  東北女子大学紀要
  
  Volume: 59 Pages: 15-19
- NAID
  120007030476
- Open Access
- Data Source
  KAKENHI-PROJECT-19K11799
[Journal Article] Two New Terpenes Isolated from Dictyostelium Cellular Slime Molds2020
- Author(s)
  Sasaki Hitomi、Kubohara Yuzuru、Ishigaki Hirotaka、Takahashi Katsunori、Eguchi Hiromi、Sugawara Akihiro、Oshima Yoshiteru、Kikuchi Haruhisa
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 12 Pages: 2895-2895
- DOI
  10.3390/molecules25122895
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H02837, KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-19K07139
[Journal Article] Derivatives of Dictyostelium Differentiation-Inducing Factors Inhibit Serum-Dependent Cell Migration of Murine Osteosarcoma LM8 Cells2019
- Author(s)
 Kubohara Y, Kikuchi H, Oshima Y.
- Journal Title
 
 Juntendo Medical Journal
 
 Volume: 65 Issue: 1 Pages: 71-76
- DOI
 10.14789/jmj.2019.65.JMJ18-OA10
- NAID
 130007631916
- ISSN
 2187-9737, 2188-2126
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-15K07964
[Journal Article] Antimicrobial Activities of Dictyostelium Differentiation-Inducing Factors and Their Derivatives2019
- Author(s)
  Kubohara Yuzuru、Shiratsuchi Yoshiko、Ishigaki Hirotaka、Takahashi Katsunori、Oshima Yoshiteru、Kikuchi Haruhisa
- Journal Title
  
  Biomolecules
  
  Volume: 9 Issue: 5 Pages: 163-163
- DOI
  10.3390/biom9050163
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-19K07139
[Journal Article] Halogen-Substituted Derivatives of Dictyostelium Differentiation-Inducing Factor-1 Suppress Serum-Induced Cell Migration of Human Breast Cancer MDA-MB-231 Cells in Vitro2019
- Author(s)
  Kyoko Totsuka、Yuka Makioka、Kyoichi Iizumi、Katsunori Takahashi、Yoshiteru Oshima、Haruhisa Kikuchi、Yuzuru Kubohara
- Journal Title
  
  Biomolecules
  
  Volume: 9 Issue: 7 Pages: 256-256
- DOI
  10.3390/biom9070256
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H02837, KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-19K07139
[Journal Article] Dictyostelium: an important source of structural and functional diversity in drug discovery.2019
- Author(s)
  Kubohara Y, Kikuchi H.
- Journal Title
  
  Cells
  
  Volume: 8 Issue: 1 Pages: 6-6
- DOI
  10.3390/cells8010006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07964
[Journal Article] Production of Novel Bispyrone Metabolites in the Cellular Slime Mold Dictyostelium giganteum Induced by Zinc(II) Ion2017
- Author(s)
  Van Hai Nguyen, Haruhisa Kikuchi, Hikaru Sasaki, Kyoichi Iizumi, Yuzuru Kubohara, Yoshiteru Oshima
- Journal Title
  
  Tetrahedron
  
  Volume: 73 Issue: 5 Pages: 583-588
- DOI
  10.1016/j.tet.2016.12.040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H03279, KAKENHI-PROJECT-15K07964
[Journal Article] Synthsis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds2017
- Author(s)
  Haruhisa Kikuchi, Ikuko Ito, Katsunori Takahashi, Hirotaka Ishigaki, Kyoichi Iizumi, Yuzuru Kubohara, Yoshiteru Oshima
- Journal Title
  
  Journal of Natural Products
  
  Volume: 80 Issue: 10 Pages: 2716-2722
- DOI
  10.1021/acs.jnatprod.7b00456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H03279, KAKENHI-PROJECT-15K07964
[Journal Article] Biological Activities of Novel Derivatives of Differentiation-Inducing Factor 3 from Dictyostelium discoideum2017
- Author(s)
 Takahashi Katsunori、Kikuchi Haruhisa、Nguyen Van Hai、Oshima Yoshiteru、Ishigaki Hirotaka、Nakajima-Shimada Junko、Kubohara Yuzuru
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 40 Issue: 11 Pages: 1941-1947
- DOI
 10.1248/bpb.b17-00484
- NAID
 130006191965
- ISSN
 0918-6158, 1347-5215
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-15K07964
[Journal Article] Glutathione S-transferase 4 is a putative DIF-binding protein that regulates the size of fruiting bodies in Dictyostelium discoideum.2016
- Author(s)
  Kuwayama H, Kikuchi H, Oshima Y, & Kubohara Y.
- Journal Title
  
  Biochem. Biophys. Rep.
  
  Volume: 8 Pages: 219-226
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07964
[Journal Article] Differentiation-inducing factor 2 modulates chemotaxis via the histidine kinase DhkC-dependent pathway in Dictyostelium discoideum.2016
- Author(s)
  Kuwayama H, & Kubohara Y.
- Journal Title
  
  FEBS Lett.
  
  Volume: 590 Issue: 6 Pages: 760-768
- DOI
  10.1002/1873-3468.12111
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07964, KAKENHI-PROJECT-24590110
[Journal Article] A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation.2015
- Author(s)
  Oladimeji P, Kubohara Y, Kikuchi H, Oshima Y, Rusch C, Skerl R, & Diakonova M.
- Journal Title
  
  Int. J. Cancer Clinic. Res.
  
  Volume: 2 Pages: 3-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07964
[Journal Article] A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation.2015
- Author(s)
  Oladimeji P, Kubohara Y, Kikuchi H, Oshima Y, Rusch C, Skerl R, & Diakonova M.
- Journal Title
  
  Int. J. Cancer Clinic. Res.
  
  Volume: 2 Pages: 3-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24590110
[Journal Article] Development of novel DIF-1 derivatives that selectively suppress innate immune responses.2015
- Author(s)
  Nguyen VH, Kikuchi H, Kubohara Y, Takahashi K, Katou Y, & Oshima Y.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Issue: 15 Pages: 4311-4315
- DOI
  10.1016/j.bmc.2015.06.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07964, KAKENHI-PROJECT-24590110
[Journal Article] Derivatives of Dictyostelium differentiation-inducing factors inhibit lysophosphatidic acid–stimulated migration of murine osteosarcoma LM8 cells.2015
- Author(s)
  Kubohara Y, Komachi M, Homma Y, Kikuchi H, & Oshima Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 463 Issue: 4 Pages: 800-805
- DOI
  10.1016/j.bbrc.2015.06.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07964, KAKENHI-PROJECT-24590110
[Journal Article] Properties of a non-bioactive fluorescent derivative of differentiation-inducing factor-3, an anti-tumor agent found in Dictyostelium discoideum.2014
- Author(s)
  Kubohara Y, Kikuchi H, Matsuo Y, Oshima Y, & Homma Y.
- Journal Title
  
  Biology Open
  
  Volume: 3 Issue: 4 Pages: 289-296
- DOI
  10.1242/bio.20146585
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590110, KAKENHI-PROJECT-15K07964
[Journal Article] Derivatives of Dictyostelium discoideum differentiation-inducing factor-3 suppress the activities of Trypanosoma cruzi in vitro and in vivo2013
- Author(s)
  Nakajima-Shimada J, Hatabu T, Hosoi Y, Onizuka Y, Kikuchi H, Oshima Y, & Kubohara Y
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590110
[Journal Article] Chlorinated Dibenzofurans Isolated from the Cellular Slime Mold, Polysphondylium filamentosum, and Their Biological Activities2013
- Author(s)
  Kikuchi, H.; Kubohara, Y.; Nguyen, V. H.; Katou, Y.; Oshima, Y. Novel
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: (In press) Issue: 15 Pages: 4628-4633
- DOI
  10.1016/j.bmc.2013.05.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710247, KAKENHI-PROJECT-24590110
[Journal Article] The Dictyostelium prestalk inducer DIF-1 directs phosphorylation of a bZIP transcription factor.2013
- Author(s)
  Yamada Y, Kubohara Y, Kikuchi H, Oshima Y, Wang HY, Ross S, & Williams JG.
- Journal Title
  
  Intenational Journal of Developmental Biology
  
  Volume: 57 Issue: 5 Pages: 375-381
- DOI
  10.1387/ijdb.130046jw
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590110
[Journal Article] Mitochondria are the target organelle of differentiation-inducing factor-3, an anti-tumor agent isolated from Dictyostelium discoideum.2013
- Author(s)
  Kubohara Y, Kikuchi H, Matsuo Y, Oshima Y, & Homma Y.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 8 Pages: e72118-e72118
- DOI
  10.1371/journal.pone.0072118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590110
[Journal Article] Br-DIF-1 accelerates dimethyl sulphoxide-induced differentiation of P19CL6 embryonic carcinoma cells into cardiomyocytes2012
- Author(s)
  Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, Furukawa K
- Journal Title
  
  Brit. J. Pharmacol
  
  Volume: 165(4) Pages: 870-879
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Br-DIF-1 accelerates dimethyl sulphoxide-induced differentiation of P19CL6 embryonic carcinoma cells into cardiomyocytes2012
- Author(s)
  Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, Furukawa KI
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 165 Issue: 4 Pages: 870-879
- DOI
  10.1111/j.1476-5381.2011.01541.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090, KAKENHI-PROJECT-23591077
[Journal Article] Isolation, Synthesis and Biological Activity of Biphenyl and m-Terphenyl-Type Compounds from Dictyostelium Cellular Slime Molds2012
- Author(s)
  Kikuchi, H.; Matsuo, Y.; Katou, Y.; Kubohara, Y.; Oshima, Y
- Journal Title
  
  Tetrahedron
  
  Volume: 68 Issue: 43 Pages: 8884-8889
- DOI
  10.1016/j.tet.2012.08.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710247, KAKENHI-PROJECT-24590110
[Journal Article] Manganese promotes phorbol ester–induced interleukin-2 production via AP-1 activation in Jurkat T-cells2012
- Author(s)
  Tanaka S, Masuda Y, Honma C, Hosaka K, Takahashi K, & Kubohara Y
- Journal Title
  
  Toxicology Letters
  
  Volume: 211 Issue: 3 Pages: 312-318
- DOI
  10.1016/j.toxlet.2012.04.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590110
[Journal Article] Derivatives of Dictyostelium differentiation-inducing factors promote mitogen-activated IL-2 production via AP-1 in Jurkat cells2011
- Author(s)
  Takahashi K, Murakami M, Kikuchi H, Oshima Y, Kubohara Y.
- Journal Title
  
  Life Sciences
  
  Volume: 88(11-12) Pages: 480-485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Artificial compounds differentially control Dictyostelium chemotaxis and cell differentiation.2011
- Author(s)
  Kuwayama H, Kikuchi H, Oshima Y, Kubohara Y.
- Journal Title
  
  Cell Structure and Function
  
  Volume: 36 Pages: 21-26
- NAID
  130004137560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Atg1 allows second-signalled autophagic cell death in Dictyostelium2011
- Author(s)
  Luciani M-F, Giusti C, Harms B, Oshima Y, Kikuchi H, Kubohara Y, Golstein P
- Journal Title
  
  Autophagy
  
  Volume: 7(6) Pages: 501-508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Artificial compounds differentially control Dictyostelium chemotaxis and cell differentiation2011
- Author(s)
  Kuwayama H, Kikuchi H, Oshima Y, Kubohara Y
- Journal Title
  
  Cell Structure and Function
  
  Volume: 36(1) Pages: 21-26
- NAID
  130004137560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Derivatives of Dictyostelium differentiation-inducing factors promote mitogen-activated IL-2 production via AP-1 in Jurkat cells.2011
- Author(s)
  Takahashi K, Murakami M, Kikuchi H, Oshima Y, Kubohara Y.
- Journal Title
  
  Life Sciences
  
  Volume: 88 Pages: 480-485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] 細胞性粘菌の細胞分化と走化性運動を制御する低分子化合物2010
- Author(s)
  久保原禅, 桑山秀一
- Journal Title
  
  生化学
  
  Volume: 82巻12号 Pages: 1132-1137
- NAID
  10027880258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Preparation of an antibody that recognizes and neutralizes Dictyostelium differentiation-inducing factor-1. Biochem. Biophys2010
- Author(s)
  Kubohara Y, Kikuchi H, Nakamura K, Matsuo Y, Oshima Y
- Journal Title
  
  Res. Commun
  
  Volume: 396(2) Pages: 364-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds.2010
- Author(s)
  Kikuchi H, Ishiko S, Nakamura K, Kubohara Y, Oshima Y.
- Journal Title
  
  Tetrahedron
  
  Volume: 66 Pages: 6000-6007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity.2010
- Author(s)
  Matsuda T, Takahashi-Yanaga F, Yoshihara T, Maenaka K, Watanabe Y, Miwa Y, Morimoto S, Kubohara Y, Hirata M, Sasaguri T.
- Journal Title
  
  Journal of Pharmacological Sciences 112
  
  Pages: 320-326
- NAID
  10027744481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Autophagy in Dictyostelium : genes and pathways2010
- Author(s)
  Calvo-Garrido J, Carilla-Latorre S, Kubohara Y, Santos N, Mesquita A, Soldati T, Golstein P, Escalante R
- Journal Title
  
  cell death and infection. Autophagy
  
  Volume: 6(6) Pages: 686-701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds2010
- Author(s)
  Kikuchi H, Ishiko S, Nakamura K, Kubohara Y, Oshima Y
- Journal Title
  
  Tetrahedron
  
  Volume: 66(32) Pages: 6000-6007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Preparation of an antibody that recognizes and neutralizes Dictyostelium differentiation-inducing factor-1.2010
- Author(s)
  Kubohara Y, Kikuchi H, Nakamura K, Matsuo Y, Oshima Y.
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 396 Pages: 364-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity2010
- Author(s)
  Matsuda T, Takahashi-Yanaga F, Yoshihara T, Maenaka K, Watanabe Y, Miwa Y, Morimoto S, Kubohara Y, Hirata M, Sasaguri T
- Journal Title
  
  J. Pharmacol. Sci
  
  Volume: 112(3) Pages: 320-326
- NAID
  10027744481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] oligosaccharide has suppressive activity against human leukemia cell proliferation2009
- Author(s)
  Hosomi O, Misawa Y, Takeya AMatahira Y, Sugahara K, Kubohara Y, Yamaura F,& Kudo S. Novel
- Journal Title
  
  Glycoconjugate J 26
  
  Pages: 189-198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590136
[Journal Article] Regulation of IL-2 production in Jurkat cells by Dictyostelium-derived factors.2009
- Author(s)
  Takahashi K, Murakami M, Hosaka K, Kikuchi H, Oshima Y, Kubohara Y.
- Journal Title
  
  Life Sciences 85
  
  Pages: 438-443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Differentiation-inducing factor-1 and-2 function also as modulators for Dictyostelium chemotaxis2009
- Author(s)
  Kuwayama H, Kubohara Y
- Journal Title
  
  PLoS ONE
  
  Volume: 4(8)
- NAID
  120007131231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Autophagic or necrotic cell death triggered by distinct motifs of the differentiation factor DIF-1.2009
- Author(s)
  Luciani M-F, Kubohara Y, Kikuchi H, Oshima Y, Golstein P.
- Journal Title
  
  Cell Death & Differentiation 16
  
  Pages: 564-570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Novel diterpene pyrone-type compounds, Metarhizin A and B, isolated from entomopathogenic fungus2009
- Author(s)
  Kikuchi H, Hoshi T, Kitayama M, Sekiya M, Katou Y, Ueda K, Kubohara Y, Sato H, Shimazu M, Kurata S & Oshima Y.
- Journal Title
  
  Metarhizium flavoviride and their structural requirements for inhibiting cellular proliferation. Tetrahedron 65
  
  Pages: 469-477
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590136
[Journal Article] Regulation of IL-2 production in Jurkat cells by Dictyostelium-derived factors2009
- Author(s)
  Takahashi K, Murakami M, Hosaka K, Kikuchi H, Oshima Y, Kubohara Y
- Journal Title
  
  Life Sciences
  
  Volume: 85(11-12) Pages: 438-443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Autophagic or necrotic cell death triggered by distinct motifs of the differentiation factor DIF-12009
- Author(s)
  Luciani M-F, Kubohara Y, Kikuchi H, Oshima Y, Golstein P
- Journal Title
  
  Cell Death & Differ
  
  Volume: 16(4) Pages: 264-570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Differentiation-inducing factor-1 and -2 function also as modulators for Dictyostelium chemotaxis.2009
- Author(s)
  kuwayama H, Kubohara Y.
- Journal Title
  
  PLoS ONE 4
- NAID
  120007131231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590090
[Journal Article] Biological activities of novel derivatives of DIF-1 isolated from Dictyostelium2008
- Author(s)
  Kikuchi H, Ishiko S, Oshima Y, Gonkan N, Hosaka K & Kubohara Y.
- Journal Title
  
  Biochem.Biophys. Res. Commun 377
  
  Pages: 1012-1017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590136
[Journal Article] Exploitation of the derivatives of Dictyostelium differentiation-inducing factor-1, which promote glucose consumption in mammalian cells2008
- Author(s)
  Kubohara Y, Kikuchi H & Oshima Y.
- Journal Title
  
  Life Sciences 83
  
  Pages: 608-612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590136
[Journal Article] Exploitation of the derivatives of Dictyostelium differentiation inducing fact or 1, which promote glucose consumption in mammalian cells.2008
- Author(s)
  Kubohara, Y. 他
- Journal Title
  
  Life Sciences 83
  
  Pages: 608-612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590136
[Journal Article] 細胞性粘菌由来の薬理活性物質DIF-1が示す抗腫瘍作用と糖代謝促進作用2007
- Author(s)
  久保原禅
- Journal Title
  
  細胞工学 26
  
  Pages: 1052-1053
- Data Source
  KAKENHI-PROJECT-19590136
[Journal Article] Pharmacological activities of the Dictyostelium differentiation-inducing factor-1 (DIF-1):Cellular slime molds are fascinating lower eukaryotes!2007
- Author(s)
  Kubohara, Y.
- Journal Title
  
  Seikagaku 79
  
  Pages: 148-151
- NAID
  10018733652
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590115
[Journal Article] Pharmacological evidence that stalk cell differentiation involves increases in the intracellular Ca^<2+> and H^+ concentrations in Dictyostelium discoidewn.2007
- Author(s)
 Kubohara Y, Arai A, Gokan N, Hosaka K.
- Journal Title
 
 Develop. Growth ＆ Differ. 49・3
 
 Pages: 253-264
- Data Source
 KAKENHI-PROJECT-17590115
[Journal Article] 細胞性粘菌由来の薬理活性物質DIF-1が示す抗腫瘍作用と糖代謝促進作用2007
- Author(s)
  久保原禅
- Journal Title
  
  細胞工学 26
  
  Pages: 1052-1053
- Data Source
  KAKENHI-PROJECT-19590136
[Journal Article] 細胞性粘菌の分化誘導因子DIF-1が示す薬理作用 : 下等生物(粘菌)は面白い2007
- Author(s)
  久保原禅
- Journal Title
  
  生化学 79・2
  
  Pages: 148-151
- NAID
  10018733652
- Data Source
  KAKENHI-PROJECT-17590115
[Journal Article] 細胞性粘菌の分化誘導因子DIF-1が示す薬理作用 : 下等生物(粘菌)は面白い!2007
- Author(s)
  久保原禅
- Journal Title
  
  生化学 79
  
  Pages: 148-151
- NAID
  10018733652
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590115
[Journal Article] Pharmacological evidence that stalk cell differentiation involves increases in the intracellular Ca^<2+> and H^+ concentrations in Dictyostelium discoideum.2007
- Author(s)
 Kubohara, Y., et al.
- Journal Title
 
 Develop. Growth ＆ Differ. 49
 
 Pages: 253-264
- NAID
 40015330264
- Description
 「研究成果報告書概要(和文)」より
- Data Source
 KAKENHI-PROJECT-17590115
[Journal Article] Dictyostelium differentiation-inducing factor-1 induces glucose transporter 1 translocation and promotes glucose uptake in mammalian cells2007
- Author(s)
  Omata W, Shibata H, Nagasawa M,Kojima I, Kikuchi H, Oshima Y, Hosaka K,& Kubohara Y
- Journal Title
  
  FEBS Journal 274
  
  Pages: 3392-3404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590136
[Journal Article] Dihydrodictyopyrone A and C : New members of dictyopyrone family isolated from Dictyostelium cellular slime molds2007
- Author(s)
  Kikuchi H, Nakamura K, Kubohara Y, Gokan N, Hosaka K, Maeda Y, & Oshima Y.
- Journal Title
  
  Tetrahedron Lett 48
  
  Pages: 5905-5909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590136
[Journal Article] Pharmacological evidence that stalk cell differentiation involves increases in the intracellular Ca~<2+>and H^+ concentrations in Dictyostelium discoideum.2007
- Author(s)
 Kubohara, Y., et al.
- Journal Title
 
 Develop. Growth ＆ Differ. 49
 
 Pages: 253-264
- NAID
 40015330264
- Description
 「研究成果報告書概要(欧文)」より
- Data Source
 KAKENHI-PROJECT-17590115
[Journal Article] Anti-leukemic activities of Dictyostelium secondary metabolites : A novel aromatic metabolite, 4-methyl-5-n-pentylbenzene-1,3-diol, isolated from Dictyostelium mucoroides suppresses cell growth in human leukemia K562 cells.2006
- Author(s)
  Kikuchi H, Oshima Y, Ichimura A, Gokan N, Hasegawa A, Hosaka K, KuboharaY.
- Journal Title
  
  Life Sciences 80・2
  
  Pages: 160-165
- Data Source
  KAKENHI-PROJECT-17590115
[Journal Article] Isolation and synthesis of a new aromatic compound, brefelamide, from Dictyostelium cellular slime molds and its inhibitory effect on the proliferation of astrocytoma cells.2005
- Author(s)
  Kikuchi H, Saito Y, Sekiya J, Okano Y, Saito M, Nakahata N, Kubohara Y, Oshima Y
- Journal Title
  
  J.Org.Chem. 70
  
  Pages: 8854-8858
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Zinc ions suppress mitogen-activated interleukin-2 production in Jurkat cells.2005
- Author(s)
  Tanaka, S., Akaishi, E., Hosaka, K., Okamura, S., Kubohara, Y.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 335
  
  Pages: 162-167
- Data Source
  KAKENHI-PROJECT-17590115
[Journal Article] Structural requirements of Dictyosterium differentiation-inducing Factors for their stalk-cell-inducing activity in Dictyosterium cells and anti-proliferative activity in K562 human leukemic cells.2005
- Author(s)
  Gokan N, Kikuchi H, Nakamura K, Oshima Y, Hosaka K, Kubohara Y.
- Journal Title
  
  Biochemical Pharmacology 70
  
  Pages: 676-685
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Isolation and synthesis of a new aromatic compound, brefelamide, from Dictyostelium cellular slime molds and its inhibitory effect on proliferation of astrocytoma cells.2005
- Author(s)
  Kikuchi, H., Saito, Y., Sekiya, J., Okano, Y., Saito, M., Nakahata, H., Kubohara, Y., Oshima, Y.
- Journal Title
  
  J.Org.Chem. 70
  
  Pages: 8854-8858
- Data Source
  KAKENHI-PROJECT-17590115
[Journal Article] Structural requirements of Dictyosterium differentiation-inducing Factors for their stalk-cell-inducing activity in Dictyosterium cells and anti-proliferative activity in K562 human leukemic cells.2005
- Author(s)
  Gokan N, Kikuchi H, Nakamura K, Oshima Y, Hosaka K, Kubohara Y.
- Journal Title
  
  Biochmical Pharmacology 70
  
  Pages: 676-685
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Structural requirements of Dictyosterium differentiation-inducing factors for their stalk-cell-inducing activity in Dictyosterium cells and anti-proliferative activity in K562 human leukemic cells.2005
- Author(s)
  Gokan N, Kikuchi H, Nakamura K, Oshima Y, Hosaka K, Kubohara Y
- Journal Title
  
  Biochemical Pharmacolgy 70
  
  Pages: 676-685
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Dictyopyrones, novel α-pyronoids isolated from Dictyostelium spp.,Promote stalk cell differentiation in Dictyostelium discoideum.2005
- Author(s)
  Arai A, Goto Y, Hasegawa A, Hosaka H, Kikuchi H, Oshima Y, Tanaka S, Kubohara Y.
- Journal Title
  
  Differentiation 73
  
  Pages: 377-384
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Dictyopyrones, novel α-pyronoids isolated from Dictyostelium spp., promote stalk cell differentiation in Dictyostelium discoideum.2005
- Author(s)
  Arai, A., Goto, Y., Hasegawa, A., Hosaka, K., Kikuchi, H., Oshima, Y., Tanaka, S., Kubohara, Y.
- Journal Title
  
  Differentiation 73
  
  Pages: 377-384
- Data Source
  KAKENHI-PROJECT-17590115
[Journal Article] Dictyopyrones, novel α-pyronoids isolated from Dictyostelium spp., p romote stalk cell differentiation in Dictyostelium discoideum.2005
- Author(s)
  Arai A, Goto Y, Hasegawa A, Hosaka H, Kikuchi H, Oshima Y, Tanaka S, Kubohara Y.
- Journal Title
  
  Differentiation 73
  
  Pages: 377-384
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Dictyopyrones, novel α-pyronoids isolated from Dictyostelium spp., promote stalk cell differentiation in Dictyostelium discoideum.2005
- Author(s)
  Arai A, Goto Y, Hasegawa A, Hosaka H, Kikuchi H, Oshima Y, Tanaka S, Kubohara Y
- Journal Title
  
  Differentiation 73
  
  Pages: 377-384
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Structural requirements of Dictyostelium differentiation-inducing factors for their stalk-cell-inducing activity in Dictyostelium cells and anti-proliferative activity in K562 human leukemic cells.2005
- Author(s)
  Gokan, N., Kikuchi, H., Nakamura, K., Oshima, Y., Hosaka, K., Kubohara, Y.
- Journal Title
  
  Biochem.Pharmacol. 70
  
  Pages: 676-685
- Data Source
  KAKENHI-PROJECT-17590115
[Journal Article] Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity.2004
- Author(s)
  Akaishi E, Narita T, Kawai S, Miwa Y, Sasaguri T, Kubohara Y
- Journal Title
  
  Eur J Pharmacol. 485
  
  Pages: 21-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Calmodulin-dependent cyclic nucleotide phosphodiesterase(PDE1) is a pharmacological target of differentiation-inducing factor-1, an anti-tumor agent isolated from Dictyostelium.2004
- Author(s)
  Shimizu K, Murata T, Tagawa T, Takahashi K, Abe Y, Hosaka K, Kubohara Y.
- Journal Title
  
  Cancer Research 64
  
  Pages: 2568-2571
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Structural requirements of dictyopyrones isolated from Dictyosterium spp. in the regulation of Dictyosterium development and in anti-leukemic activity.2004
- Author(s)
  Kikuchi H, Sasaki K, Maeda Y, Amagai A, Kubohara Y, Oshima Y
- Journal Title
  
  Bioorg.Med.Chem. 12
  
  Pages: 3203-3214
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity.2004
- Author(s)
  Akaishi, E., Narita, T., Kawai, S., Miwa, Y, Sasaguri, T., Hosaka, K., Kubohara, Y.
- Journal Title
  
  Eur.J.Pharmacol. 485
  
  Pages: 21-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) is a pharmacological target of differentiation-inducing factor-1, an anti-tumor agent isolated from Dictyostelium.2004
- Author(s)
  Shimizu, K., Murata, T., Tagawa, T., Takahashi, K., Ishikawa, R., Abe, Y, Hosaka, K., Kubohara, Y.
- Journal Title
  
  Cancer Res. 64
  
  Pages: 2568-2571
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Structural requirements of dictyopyrones isolated from Dictyostelium spp. in the regulation of Dictyostelium development and in anti-leukemic activity.2004
- Author(s)
  Kikuchi, H., Sasaki, K., Sekiya, J., Maeda, Y., Amagai, A., Kubohara, Y., Oshima, Y.
- Journal Title
  
  Bioorg.Med.Chem. 12
  
  Pages: 3203-3214
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity.2004
- Author(s)
  Akaishi E, Narita T, Kawai S, Miw, Hosaka K, Kubohara Y.
- Journal Title
  
  Eur J Pharmacol. 485
  
  Pages: 21-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Prespore-to-stalk convertion involves the production of a pathway-specific glycoprotein, wst25, in the cellular slime mould Dictyosterium discoideum.2004
- Author(s)
  Kubohara Y, Arai A, Takahashi K, Hosaka K, Okamoto K
- Journal Title
  
  Biochem.Biophys.Res.Commun. 320
  
  Pages: 468-473
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Prespore-to-stalk conversion involves the production of a pathway-specific glycoprotein, wst25, in the cellular slime mould Dictyosterium discoideum.2004
- Author(s)
  Kubohara, Y., Arai, A., Takahashi, K., Hosaka, K., Okamoto, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 320
  
  Pages: 468-473
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Prespore-to-stalk conversion involves the production of a pathway-specific glvcoprotein, wst25 in the cellular slime mould Dictyosterium discoideum.2004
- Author(s)
  Kubohara, Y., Arai, A., Takahashi, K., Hosaka, K., Okamoto, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 320
  
  Pages: 468-473
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Structural requirements of dictyopyrones isolated from Dictyostelium spp.in the regulation of Dictyostelium development and in anti-leukemic activity.2004
- Author(s)
  Kikuchi H, Sasaki K, Sekiya J, Maeda Y, Amagai A, Kubohara Y, Oshima Y
- Journal Title
  
  Bioorg.Med.Chem. 12
  
  Pages: 3203-3214
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) is a pharmacological target of differentiation-inducing factor-1, an anti-tumor agent isolated from Dictyostelium.2004
- Author(s)
  Shimizu K, Murata T, Tagawa T, Takahashi K, Abe Y, Hosaka K, Kubohara Y
- Journal Title
  
  Cancer Research 64
  
  Pages: 2568-2571
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Journal Article] Calmodulin-dependent cyclic nucleotide phosphoiesterase (PDE1) is a pharmacological target of differentiation-inducing factor-1, an anti-tumor agent isolated from Dictyostelium.2004
- Author(s)
  Shimizu K, Murata T, Tagawa T, Takahashi K, Ishikawa R, Abe Y, Hosaka K, Kubohara Y.
- Journal Title
  
  Cancer Research 64
  
  Pages: 2568-2571
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3β and degrades cyclin D1 in mammalian cells.2003
- Author(s)
  Takahashi-Yanaga, F., Taba, Y., Miwa, Y., Kubohara, Y., Watanabe, Y., Hirata, M., Morimoto, S., Sasaguri, T.
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 9663-9670
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity2003
- Author(s)
  Akashi E, Narita T, Kawai S, Miwa Y, Sasaguri T, Hosaka K, Kubohara Y.
- Journal Title
  
  European Journal of Pharmacology 485
  
  Pages: 21-29
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Differentiation-inducing factor-1(DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK dependent pathway.2003
- Author(s)
  Kanai, M., Konda, Y., Nakajima, T., Izumi, Y, Nanakin, A., Kanda, N., Kubohara, Y., Chiba, T.
- Journal Title
  
  Oncogene 22
  
  Pages: 548-554
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Differentiation-inducing factor-1(DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK dependent pathway.2003
- Author(s)
  Kanai M, Konda Y, Nakajima T, Izumi Y, Nanakin A, Kanda N, Kubohara Y, Chiba T
- Journal Title
  
  Oncogene 22
  
  Pages: 548-554
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3β and degrades cyclin D1 in mammalian cells.2003
- Author(s)
  Takahashi-Yanaga F, Taba Y, Miwa Y, Kubohara Y, Watanabe Y, Hirata M, Morimoto S, Sasaguri T
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 9663-9670
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Zinc inhibits calcineurin activity in vitro by competing with nickel.2003
- Author(s)
  Takahashi K, Akaishi E, Abe Y, Ishikawa R, Tanaka S, Hosaka K, Kubohara Y
- Journal Title
  
  Biochem.Biophys.Res.Commun. 307
  
  Pages: 64-68
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Journal Article] Zinc inhibits calcineurin activity in vitro by competing with nickel.2003
- Author(s)
  Takahashi, N., Akaishi, E., Abe, Y, Ishikawa, R., Tanaka, S., Hosaka, K., Kubohara, Y.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 307
  
  Pages: 64-68
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Patent] マラリア予防治療薬2021
- Inventor(s)
  美田敏宏、久保原禅、菊地晴久、大島吉輝
- Industrial Property Rights Holder
  学校法人順天堂
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-055575
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K07139
[Patent] マラリア原虫の増殖抑制剤2019
- Inventor(s)
  美田敏宏、久保原禅、菊地晴久、大島吉輝
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-040682
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K07139
[Patent] マラリア原虫の増殖抑制剤2019
- Inventor(s)
  美田敏宏、久保原禅、菊地晴久、大島吉輝
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-040682
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-15K07964
[Patent] アミド誘導体2014
- Inventor(s)
  菊地晴久、大島吉輝、服部俊夫、久保原禅、他
- Industrial Property Rights Holder
  東北大学、群馬大学、扶桑薬品工業株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-038919
- Filing Date
  2014-02-21
- Data Source
  KAKENHI-PROJECT-24590110
[Patent] ジクチオピロン誘導体又はジヒドロジクチオピロン誘導体を有効成分とするオステオポンチン産生阻害剤2013
- Inventor(s)
  菊地晴久、大島吉輝、服部俊夫、久保原禅、他
- Industrial Property Rights Holder
  群馬大学、東北大学、扶桑薬品工業株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-046197
- Filing Date
  2013-03-08
- Data Source
  KAKENHI-PROJECT-24590110
[Patent] Method of lowering blood glucose and method of treating diabetes and obesity2010
- Inventor(s)
  久保原禅, 柴田宏
- Industrial Property Rights Holder
  群馬大学
- Acquisition Date
  2010-12-07
- Overseas
- Data Source
  KAKENHI-PROJECT-21590090
[Patent] 抗腫瘍剤2010
- Inventor(s)
  久保原禅, 保坂公平
- Industrial Property Rights Holder
  群馬大学
- Acquisition Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-21590090
[Patent] 走化性運動制御剤2010
- Inventor(s)
  久保原禅, 岡島史和, 小町麻由美, 桑山秀一, 大島吉輝, 菊地晴久
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2010-004319
- Filing Date
  2010-01-12
- Data Source
  KAKENHI-PROJECT-21590090
[Patent] 抗トリパノソーマ剤およびトリパノソーマ症治療薬2010
- Inventor(s)
  久保原禅, 嶋田淳子
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2010-163039
- Filing Date
  2010-07-20
- Data Source
  KAKENHI-PROJECT-21590090
[Patent] 走化性運動制御剤2010
- Inventor(s)
  久保原禅、岡島史和、小町麻由美、桑山秀一、大島吉輝、菊地晴久
- Industrial Property Rights Holder
  久保原禅、桑山秀一、大島吉輝、菊地晴久
- Industrial Property Number
  2010-004319
- Filing Date
  2010-01-12
- Data Source
  KAKENHI-PROJECT-21590090
[Patent] 抗トリパノソーマ剤およびトリパノソーマ症治療薬2010
- Inventor(s)
  久保原禅、嶋田淳子
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2010-163039
- Filing Date
  2010-07-20
- Data Source
  KAKENHI-PROJECT-21590090
[Patent] 細胞性粘菌を利用した医薬候補物質のスクリーニング法2010
- Inventor(s)
  久保原禅
- Industrial Property Rights Holder
  群馬大学
- Acquisition Date
  2010-02-12
- Data Source
  KAKENHI-PROJECT-21590090
[Patent] 糖代謝促進剤並びに肥満及び糖尿病治療薬のスクリーニング方法2010
- Inventor(s)
  久保原禅, 柴田宏
- Industrial Property Rights Holder
  群馬大学
- Acquisition Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-21590090
[Patent] インターロイキン-2産生抑制剤2009
- Inventor(s)
  久保原禅, 村上正巳, 高橋克典, 大島吉輝, 菊地晴久
- Industrial Property Rights Holder
  群馬大学、東北大学
- Industrial Property Number
  2009-112974
- Filing Date
  2009-05-07
- Data Source
  KAKENHI-PROJECT-21590090
[Patent] 新規DIF-1誘導体2009
- Inventor(s)
  久保原禅
- Industrial Property Rights Holder
  群馬大学
- Filing Date
  2009-02-05
- Data Source
  KAKENHI-PROJECT-19590136
[Patent] 抗腫瘍剤2009
- Inventor(s)
  久保原禅, 保坂公平
- Industrial Property Rights Holder
  群馬大学
- Acquisition Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-21590090
[Patent] インターロイキン-2産生抑制剤2009
- Inventor(s)
  久保原禅、村上正巳、高橋克典、大島吉輝、菊地晴久
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2009-112974
- Filing Date
  2009-05-07
- Data Source
  KAKENHI-PROJECT-21590090
[Patent] 新規DIF-1誘導体2009
- Inventor(s)
  久保原禅
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2009-025149
- Filing Date
  2009-02-05
- Data Source
  KAKENHI-PROJECT-19590136
[Patent] Method of lowering blood glucose and method of preventing or treating blood glucose and method of preventing or treating diabetes and obesity2007
- Inventor(s)
  久保原禅、柴田宏
- Industrial Property Rights Holder
  群馬大学
- Filing Date
  2007-10-24
- Data Source
  KAKENHI-PROJECT-19590136
[Patent] Method of lowering blood glucose and method of preventing or treating bolld glucose and method of preventing or treating diabetes and obesity2007
- Inventor(s)
  久保原禅, 柴田宏
- Industrial Property Rights Holder
  群馬大学
- Filing Date
  2007-10-24
- Overseas
- Data Source
  KAKENHI-PROJECT-19590136
[Patent] 抗腫瘍剤2006
- Inventor(s)
  久保原禅, 保坂公平
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2006-022530
- Filing Date
  2006-01-31
- Data Source
  KAKENHI-PROJECT-17590115
[Patent] 抗腫瘍剤2006
- Inventor(s)
  久保原禅, 保坂公平
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2006-022530
- Filing Date
  2006-01-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590115
[Patent] 細胞性粘菌より単離された新規抗腫瘍因子2005
- Inventor(s)
  久保原禅, 保坂公平
- Filing Date
  2005-08-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590105
[Patent] 細胞性粘菌を利用した医薬候補物質のスクリーニング方法2005
- Inventor(s)
  久保原禅
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2005-166839
- Filing Date
  2005-06-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590115
[Patent] 抗腫瘍剤2005
- Inventor(s)
  久保原禅, 保坂公平
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2005-223927
- Filing Date
  2005-08-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590115
[Patent] 糖代謝促進剤並びに肥満及び糖尿病治療薬のスクリーニング方法2005
- Inventor(s)
  久保原禅, 柴田宏
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2005-114576
- Filing Date
  2005-04-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590115
[Patent] 抗腫瘍剤2005
- Inventor(s)
  久保原禅, 保坂公平
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2005-223927
- Filing Date
  2005-08-02
- Data Source
  KAKENHI-PROJECT-17590115
[Patent] 糖代謝促進剤並びに肥満及び糖尿病治療薬のスクリーニング方法2005
- Inventor(s)
  久保原禅, 柴田宏
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2005-114576
- Filing Date
  2005-04-12
- Data Source
  KAKENHI-PROJECT-17590115
[Patent] 細胞性粘菌を利用した医薬候補物質のスクリーニング方法2005
- Inventor(s)
  久保原禅
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2005-166839
- Filing Date
  2005-06-07
- Data Source
  KAKENHI-PROJECT-17590115
[Patent] PDE1阻害剤2004
- Inventor(s)
  久保原禅, 保坂公平, 清水香澄, 村田琢, 田川俊郎
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2004-108018
- Filing Date
  2004-03-31
- Data Source
  KAKENHI-PROJECT-15590123
[Patent] PDE1阻害剤2004
- Inventor(s)
  久保原禅, 保坂公平, 清水香澄, 村田琢, 田川俊郎
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2004-108018
- Filing Date
  2004-03-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590123
[Presentation] 細胞性粘菌（Dictyostelium discoideum）柄細胞分化誘導因子を用いた新規誘導体の抗マラリア活性2023
- Author(s)
  吉田菜穂子、平井誠、菊地晴久、久保原禅、美田敏宏
- Organizer
  日本寄生虫学会
- Data Source
  KAKENHI-PROJECT-19K07139
[Presentation] 細胞性粘菌由来の生物活性物質DIF-1とその誘導体によるタンパク質代謝制御機構の解析2022
- Author(s)
  山田龍，矢野敏史，山越正汰，菊地晴久，久保原禅，原太一
- Organizer
  日本栄養食糧学会
- Data Source
  KAKENHI-PROJECT-19K07139
[Presentation] DIF-1 promotes glucose uptake in mouse C2C12 myotube cells2022
- Author(s)
  Fukunaga Y, Nakanishi K, Sugita H, Kubohara Y.
- Organizer
  日本薬理学会
- Data Source
  KAKENHI-PROJECT-19K07139
[Presentation] DIF誘導体が熱帯熱マラリア原虫の増殖を阻害する2022
- Author(s)
  美田敏弘、平井誠、吉田菜穂子、菊地晴久、久保原禅
- Organizer
  日本細胞性粘菌学会
- Data Source
  KAKENHI-PROJECT-19K07139
[Presentation] DIF-1による糖代謝促進作用とAMP kinase2020
- Author(s)
  久保原禅，本間好，大島吉輝，菊地晴久
- Organizer
  日本細胞性粘菌学会
- Data Source
  KAKENHI-PROJECT-19K07139
[Presentation] ハロゲン置換した DIF 誘導体の抗腫瘍作用2019
- Author(s)
  久保原禅, 戸塚響子, 牧岡優佳, 飯泉恭一, 大島吉輝, 菊地晴久
- Organizer
  日本細胞性粘菌学会
- Data Source
  KAKENHI-PROJECT-19K07139
[Presentation] DIF誘導体の有する抗菌活性2019
- Author(s)
  久保原禅, 白土佳子, 石垣宏尚, 高橋克典, 大島吉輝, 菊地晴久
- Organizer
  日本細胞性粘菌学会
- Data Source
  KAKENHI-PROJECT-19K07139
[Presentation] 6-NITROTRYPTOPHAN IN IMMUNOGLOBULIN LIGHT CHAIN AS A NEW POSSIBLE BIOMARKER FOR ATOPIC DERMATITIS2018
- Author(s)
  Kyoichi Iizumi, Hiroaki Kawasaki, Ayako Shigenaga, Mitsutoshi Tominaga, Ayaka Otsu, Atsuko Kamo, Yayoi Kamata, Yuzuru Kubohara, Kenji Takamori, Fumiyuki Yamakura
- Organizer
  15th International Society for Tryptophan Research (ISTRY) Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01835
[Presentation] 新規DIF-3誘導体、DIF-3(+3)とHex-DIF-3、の生物活性の検討2017
- Author(s)
  高橋克典、Nguyen Van Hai、菊地晴久、大島吉輝、嶋田淳子、久保原禅
- Organizer
  日本細胞性粘菌学会
- Data Source
  KAKENHI-PROJECT-15K07964
[Presentation] DIF-1とその誘導体が有する抗菌活性の研究2017
- Author(s)
  久保原禅、佐々木啓、菊地晴久、大島吉輝
- Organizer
  日本細胞性粘菌学会
- Data Source
  KAKENHI-PROJECT-15K07964
[Presentation] 創薬資源としての細胞性粘菌2017
- Author(s)
  久保原禅
- Organizer
  つくば藻類プロティストフォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-15K07964
[Presentation] DIF-1の機能とミトコンドリアの関係2016
- Author(s)
  久保原禅、菊地晴久、Nguyen Van Hai、桑山秀一、大島吉輝
- Organizer
  日本細胞性粘菌学会
- Place of Presentation
  上智大学（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-15K07964
[Presentation] DIF-2による粘菌走化性運動の制御メカニズム2015
- Author(s)
  桑山秀一、久保原禅
- Organizer
  日本細胞性粘菌学会
- Place of Presentation
  弘前大学（青森県弘前市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-15K07964
[Presentation] １型糖尿病モデルラットの血糖値に対するDIF-1（経口投与）の効果2015
- Author(s)
  河原田律子、中村彰男、高橋克典、菊地晴久、大島吉輝、久保原禅
- Organizer
  日本細胞性粘菌学会
- Place of Presentation
  弘前大学（青森県弘前市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-15K07964
[Presentation] DIF-2による粘菌走化性運動の制御メカニズム2015
- Author(s)
  桑山秀一、久保原禅
- Organizer
  日本細胞性粘菌学会第5回例会
- Place of Presentation
  弘前大学（青森県弘前市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-24590110
[Presentation] １型糖尿病モデルラットの血糖値に対するDIF-1（経口投与）の効果2015
- Author(s)
  河原田律子、中村彰男、高橋克典、菊地晴久、大島吉輝、久保原禅
- Organizer
  日本細胞性粘菌学会第5回例会
- Place of Presentation
  弘前大学（青森県弘前市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-24590110
[Presentation] ヒトがん細胞が高発現するマーカーとオリゴ糖添加による影響2015
- Author(s)
  牧岡優佳、山本菜々子、久保原禅、細見修
- Organizer
  第29回日本キチン・キトサン学会大会
- Place of Presentation
  東海大学熊本キャンパス（熊本県熊本市）
- Year and Date
  2015-08-20
- Data Source
  KAKENHI-PROJECT-24590110
[Presentation] Jurkat T細胞においてマイトジェン刺激で活性化される転写調節因子のマンガンによる影響2015
- Author(s)
  中島徹、田中進、田中佑季、秋山珠璃、久保原禅、保坂公平
- Organizer
  日本生化学会第88回大会
- Place of Presentation
  京都国際会議場（京都府京都市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-24590110
[Presentation] Jurkat T細胞においてマイトジェン刺激で活性化される転写調節因子のマンガンによる影響2015
- Author(s)
  中島徹、田中進、田中佑季、秋山珠璃、久保原禅、保坂公平
- Organizer
  日本生化学会
- Place of Presentation
  京都国際会議場（京都府京都市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15K07964
[Presentation] Glutathione S-transferase 4 (GST4) is a putative binding protein for DIFs that regulate the size of fruiting bodies in D. discoideum2014
- Author(s)
  久保原禅、菊地晴久、大島吉輝、桑山秀一
- Organizer
  日本細胞性粘菌学会第４回例会
- Place of Presentation
  東北大学（仙台）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-24590110
[Presentation] 細胞性粘菌由来化合物DIF-1誘導体の自然免疫抑制作用とその構造活性相関2014
- Author(s)
  Van Hai Nguyen、菊地晴久、久保原禅、大島吉輝
- Organizer
  日本細胞性粘菌学会第４回例会
- Place of Presentation
  東北大学（仙台）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-24590110
[Presentation] Br-DIF-1による胚性癌腫細胞(P19CL6)の1%DMSOによる拍動心筋様細胞への分化促進におけるT型カルシウムチャネルの役割2012
- Author(s)
  瀬谷和彦, 金丸幸太, 松木瑞穂, 本郷恭子, 北原晴男, 菊地晴久, 大島吉輝, 久保原禅. 奥村謙, 元村成, 古川賢一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] Br-DIF-1による胚性癌腫細胞 (P19CL6) の1% DMSOによる拍動心筋様細胞への分化促進におけるT型カルシウムチャネルの役割2012
- Author(s)
  瀬谷和彦, 金丸幸太, 松木瑞穂, 本郷恭子, 北原晴男, 菊地晴久, 大島吉輝, 久保原禅, 奥村謙, 元村成, 古川賢一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] P19CL6胚性癌腫細胞の1%DMSOによる拍動心筋様細胞への分化誘導に及ぼすBr-DIF-1の作用2012
- Author(s)
  瀬谷和彦, 金丸幸太, 松木瑞穂, 本郷恭子, 北原晴男, 菊地晴久, 大島吉輝, 久保原禅. 奥村謙, 元村成, 古川賢一
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] P19CL6胚性癌腫細胞の1% DMSOによる拍動心筋様細胞への分化誘導に及ぼすBr-DIF-1の作用2012
- Author(s)
  瀬谷和彦, 金丸幸太, 松木瑞穂, 本郷恭子, 北原晴男, 菊地晴久, 大島吉輝, 久保原禅, 奥村謙, 元村成, 古川賢一
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] Br-DIF-1 accelerates 1% dimethyl sulfoxide-induced cardiomyocyte differentiation of P19CL6 embryonic carcinoma cells2011
- Author(s)
  Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, Furukawa K-I
- Organizer
  The 28th Annual Meeting of ISHR Japanese Section
- Place of Presentation
  Tokyo
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] Derivatives of Dictyostelium differentiation-inducing factors regulate mitogen-induced interleukin-2 production in Jurkat cells2011
- Author(s)
  久保原禅, 高橋克典, 村上正巳, 菊地晴久, 大島吉輝
- Organizer
  日本細胞生物学会第63回大会
- Place of Presentation
  札幌
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] Br-DIF-1 accelerates 1% dimethyl sulfoxide-induced cardiomyocyte differ entiation of P19CL6 embryonic carcinoma cells2011
- Author(s)
  Seya K, Kanemaru K, Matsuki M, Hongo K, Kitahara H, Kikuchi H, Oshima Y, Kubohara Y, Okumura K, Motomura S, Furukawa K-I
- Organizer
  The 28th Annual Meeting of ISHR Japanese Section
- Place of Presentation
  東京
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] 細胞性粘菌分化誘導因子DIF-3およびその誘導体による抗Trypanosoma cruzi作用の検討2010
- Author(s)
  細井友夏里, 久保原禅, 畑生俊光, 嶋田淳子
- Organizer
  日本寄生虫学会
- Place of Presentation
  旭川
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] 細胞性粘菌の分化誘導因子DIF-1とDIF-2は走化性運動の制御因子としても機能する2010
- Author(s)
  桑山秀一、久保原禅
- Organizer
  生体運動研究班会議
- Place of Presentation
  中央大学(東京)
- Year and Date
  2010-01-10
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] 新規生物資源の開拓ー昆虫寄生糸状菌と卵菌ー2010
- Author(s)
  菊地晴久, 佐藤雄一, 星朋子, 喜多山実, 関谷瑞樹, 礒辺真人, 三原健, 久保原禅, 佐藤大樹, 島津光明, 加藤泰弘, 倉田祥一朗, 大島吉輝
- Organizer
  第52回天然有機化合物討論会
- Place of Presentation
  静岡
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] 多機能分子DIFの受容体の探索2010
- Author(s)
  久保原禅, 桑山秀一, 菊地晴久, 大島吉輝
- Organizer
  第13回細胞性粘菌研究会
- Place of Presentation
  富山
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] 細胞性粘菌の分化誘導因子DIF-1とDIF-2は走化性運動の制御因子としても機能する2010
- Author(s)
  桑山秀一, 久保原禅
- Organizer
  生体運動研究班会議
- Place of Presentation
  東京
- Year and Date
  2010-01-10
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] DIFアミド化誘導体による粘菌柄細胞分化と走化性運動の制御2010
- Author(s)
  久保原禅, 桑山秀一, 菊地晴久, 大島吉輝
- Organizer
  第13回細胞性粘菌研究会
- Place of Presentation
  富山
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] 柄細胞分化誘導因子DIF-1とDIF-2は粘菌走化性運動の制御因子としても機能する2009
- Author(s)
  桑山秀一, 久保原禅
- Organizer
  第12回細胞性粘菌研究会
- Place of Presentation
  山口
- Year and Date
  2009-10-10
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] Induction of autophagy in mouse fibloblast NIH3T3 cells by DIF-1, a stalk cell differentiation inducing factor of the cellular slime mould Dictyostelium discoideum and its derivatives (DIFs)2009
- Author(s)
  根津亜季子, 久保原禅, 菊地晴久, 大島吉輝, 山本章嗣
- Organizer
  第61回日本細胞生物学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] Jurkat T細胞におけるInterleukin-2産生に対するDIF誘導体の効果2009
- Author(s)
  久保原禅, 高橋克典, 村上正巳, 菊地晴久, 大島吉輝
- Organizer
  第12回細胞性粘菌研究会
- Place of Presentation
  山口
- Year and Date
  2009-10-10
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] Jurkat T細胞におけるInterleukin-2産生に対するDIF誘導体の効果2009
- Author(s)
  久保原禅、高橋克典、村上正巳、菊地晴久、大島吉輝
- Organizer
  第12回細胞性粘菌研究会
- Place of Presentation
  山口大学(山口市)
- Year and Date
  2009-10-10
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] 柄細胞分化誘導因子DIF-1とDIF-2は粘菌走化性運動の制御因子としても機能する2009
- Author(s)
  桑山秀一、久保原禅
- Organizer
  第12回細胞性粘菌研究会
- Place of Presentation
  山口大学(山口市)
- Year and Date
  2009-10-10
- Data Source
  KAKENHI-PROJECT-21590090
[Presentation] Biological activities of DIF-1 derivatives.2008
- Author(s)
  Kubohara, Y. 他
- Organizer
  International Dictyostelium conference
- Place of Presentation
  筑波
- Year and Date
  2008-09-16
- Data Source
  KAKENHI-PROJECT-19590136
[Presentation] Biological activities of DIF-1 derivatives2008
- Author(s)
  Kubohara Y, Kikuchi H,& Oshima Y.
- Organizer
  International Dictyostelium conference
- Place of Presentation
  Tsukuba
- Year and Date
  2008-09-16
- Data Source
  KAKENHI-PROJECT-19590136
[Presentation] 胚性癌腫細胞(P19.CL6)の心筋細胞への分化におけるBr-DIF-1の役割2008
- Author(s)
  瀬谷和彦、(他9名)、久保原禅、古川賢一
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19590136
[Presentation] Anti-leukemic activities of Dictyostelium secondary metabolites:A novel aromatic metabolite,4-methyl-5-n-pentylbenzene-1,3-diol,isolated from Dictyostelium mucoroides suppresses cell growth in human leukemia K562 and HL-60 cells.2007
- Author(s)
  久保原禅, 他
- Organizer
  細胞生物学会・発生生物学会合同学会
- Place of Presentation
  福岡
- Year and Date
  2007-05-30
- Data Source
  KAKENHI-PROJECT-19590136
[Presentation] 哺乳類細胞に対するDIF-1の糖代謝促進作用2007
- Author(s)
  久保原禅、小俣和香、柴田宏、小島至、保坂公平、菊地晴久, 大島吉輝
- Organizer
  第10回細胞性粘菌研究会
- Place of Presentation
  弘前
- Year and Date
  2007-11-03
- Data Source
  KAKENHI-PROJECT-19590136
[Presentation] 哺乳類細胞に対するDIF-1およびその誘導体の糖代謝促進作用2007
- Author(s)
  久保原禅、小俣和香、柴田宏、小島至、保坂公平、菊地晴久, 大島吉輝
- Organizer
  第10回細胞性粘菌研究会
- Place of Presentation
  弘前
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-19590136
[Presentation] 哺乳類細胞に対するDIF-1の薬理作用2007
- Author(s)
  久保原禅
- Organizer
  第10回細胞性粘菌研究会
- Place of Presentation
  弘前
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-19590136
[Presentation]2007
- Author(s)
  久保原禅
- Organizer
  第10回細胞性粘菌研究会
- Place of Presentation
  弘前
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-19590136
[Presentation] Anti-leukemic activities of Dictyostelium secondary metabolites : A novel aromatic metabolite, 4-methyl-5- n-pentylbenzene-1,3-diol, isolated from Dictyostelium mucoroides suppresses cell growth in human leukemia K562 and HL-60 cells2007
- Author(s)
  久保原禅、後閑直美、保坂公平、菊地晴久、大島吉輝
- Organizer
  細胞生物・発生生物合同学会
- Place of Presentation
  福岡
- Year and Date
  2007-05-30
- Data Source
  KAKENHI-PROJECT-19590136
[Presentation] 細胞性粘菌由来の薬理活性物質によるインターロイキン-2(IL-2)発現制御
- Author(s)
  高橋克典，村上正巳，菊池晴久，大島吉輝，久保原禅
- Organizer
  第59回日本臨床検査医学学術集会
- Place of Presentation
  京都国際会館
- Invited
- Data Source
  KAKENHI-PROJECT-24590110
[Presentation] 南米シャーガス病の病原虫トリパノソーマに対するDIFの効果
- Author(s)
  嶋田淳子、細井友夏里、畑生俊光、菊地晴久、大島吉輝、久保原禅
- Organizer
  日本細胞性粘菌学会
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-24590110
[Presentation] 生物活性の無いDIF-3蛍光体の特性
- Author(s)
  久保原禅、菊地晴久、松尾祐介、大島吉輝、本間好
- Organizer
  日本細胞性粘菌学会
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-24590110
[Presentation] HeLa細胞におけるDIF蛍光体の局在と機能
- Author(s)
  久保原禅、菊地晴久、松尾祐介、大島吉輝、本間好
- Organizer
  日本細胞性粘菌学会第２回例会
- Place of Presentation
  東京大学
- Invited
- Data Source
  KAKENHI-PROJECT-24590110

1. KOJIMA Itaru (60143492)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
2. HOSAKA Kohei (70108992)

# of Collaborated Projects: 4 results

# of Collaborated Products: 29 results
3. OSHIMA Yoshiteru (00111302)

# of Collaborated Projects: 3 results

# of Collaborated Products: 48 results
4. 菊地晴久 (90302166)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
5. IIZUMI Kyoichi (30439351)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. 山倉文幸 (20053358)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. 原太一 (00392374)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
8. MOGAMI Hideo (90311604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Sugiyama Yoshie (60308210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Sasaki Hiraku (20384969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 的崎尚 (80252782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 齊藤宣一 (00334706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 仙葉隆 (30196985)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 永井敏隆 (40112172)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 手老篤史 (60431326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 桑山秀一 (40397659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 池郁生 (40183157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 松本綾子 (20833825)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 川崎広明 (40531380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 高橋克典 (90597551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 木村鮎子 (50553616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 福永優子 (80254522)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 美田敏宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 平井誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kubohara Yuzuru 久保原 禅

KUBOHARA Yuzuru 久保原 禅

久保原 禅 クボハラ ユズル

Research Projects

Research Products

Co-Researchers

細胞性粘菌由来化合物をリードとした新規肥満治療薬・糖尿病治療薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

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免疫系培養細胞を用いたセクリトーム解析による新規生物活性物質の網羅的探索

Principal Investigator

Project Period (FY)

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Review Section

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Effects of moderate exercise on type I allergy

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Drug development using biologically active substances derived from D. discoideum as seedsPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Search for anti-diabetic agents based on protein nitration

Principal Investigator

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Reclassification of [Pasteurella] pneumotropica and detection of virulence determinants.

Principal Investigator

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Research on pharmacologically active molecule DIF found in the cellular slime mold Dictyostelium discoieumPrincipal Investigator

Principal Investigator

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Mathematical modelling of diffusion-drift system of double chemotaxis type coupled with fluid

Principal Investigator

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Study on the bio-active molecule, DIF, found in the cellular slime mold Dictyostelium discoideumPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Study on the bio-active molecule, DIF, found in the soil micro-organism Dictyostelium discoideumPrincipal Investigator

Principal Investigator

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Research Institution

Analysis of the mechanisms of the actions of DIF, a bio-active compound isolated from a soil micro-organism, and development of effective DIF derivativesPrincipal Investigator

Principal Investigator

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Research Institution

Analysis of the mechanisms of the actions of DIF-1 and its derivatives, anti-tumor agents isolated from DictyosteliumPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Search for novel anti-tumor drugs and study on the action mechanism

Principal Investigator

Kubohara Yuzuru 久保原禅

KUBOHARA Yuzuru 久保原禅

久保原禅クボハラユズル