Yanagisawa Daijiro 柳沢大治郎

… Alternative Names

YANAGISAWA Daijiro 柳沢大治郎

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Researcher Number	50581112
Other IDs
Affiliation (Current)	2025: 滋賀医科大学, 神経難病研究センター, 准教授
Affiliation (based on the past Project Information) *help	2015 – 2025: 滋賀医科大学, 神経難病研究センター, 准教授 2013 – 2014: 滋賀医科大学, 分子神経科学研究センター, 助教
Review Section/Research Field	Principal Investigator Biomedical engineering/Biomaterial science and engineering / Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Basic Section 90110:Biomedical engineering-related / Basic Section 54040:Metabolism and endocrinology-related / Medium-sized Section 46:Neuroscience and related fields / Radiation science
Keywords	Principal Investigator MRI / フッ素MRI / アルツハイマー病 / タウ / 神経原線維変化 / 老人斑 / 神経変性疾患 / タウオパチー / MID1 / 認知症 … More / アミロイド病理 / タウ病理 / 遺伝的背景 / rTg4510 / 遺伝子改変マウス / 画像解析 / 分子イメージング / 診断法 … More Except Principal Investigator アルツハイマー病 / 核磁気共鳴画像 / 画像診断 / 認知症 / microRNA / 脂質代謝 / 糖代謝 / マイクロRNA / サルコペニア / ミトコンドリア / 非ヒト霊長類モデル / アミロイドオリゴマー / アミロイド / タウ / 組織細胞化学 / 神経科学 / タウタンパク / 診断 / プリオン / AI / 認知用 / 有機合成成 / Aβオリゴマー / 画像診断法 / 治療薬 / フッ素MRI / アミロイドβオリゴマー / 有機合成 / MRI / 13C-MR / アルツハイマーモデル / １３C-NMR / 13C-NMR / グルコース代謝 / 脳代謝画像 / APPマウス Less

認知症タウ病理の抑制を目的とした新規治療標的の創出Principal Investigator
- Principal Investigator
  
  柳沢大治郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
Simultaneous analysis of multiple abnormal brain proteins in Alzheimer's disease using multiple fluorine MR imaging
- Principal Investigator
  
  遠山育夫
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Shiga University of Medical Science
Study of the role of MID1 in tauopathies and its application as a therapeutic targetPrincipal Investigator
- Principal Investigator
  
  柳沢大治郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Shiga University of Medical Science
Role of microRNAs in the regulation of mitochondrial function to sarcopenia and cognitive function.
- Principal Investigator
  
  森野勝太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Shiga University of Medical Science
Development of AI technology to detect prion activity of pathogenic proteins in nasal mucosa and its application to diagnosis of dementia
- Principal Investigator
  
  遠山育夫
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 46:Neuroscience and related fields
- Research Institution
  Shiga University of Medical Science
Development of novel ligands for in vivo imaging of amyloid oligomers in the brain of Alzheimer's disease
- Principal Investigator
  
  Taguchi Hiroyasu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Shiga University of Medical Science
Evaluation of the progression of pathological changes in Alzheimer's disease using MRIPrincipal Investigator
- Principal Investigator
  
  Yanagisawa Daijiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Shiga University of Medical Science
Double-probe imaging for simultaneous detection of amyloid and tau using fluorine-19 MRIPrincipal Investigator
- Principal Investigator
  
  Yanagisawa Daijiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Shiga University of Medical Science
Study of a highly sensitive C-13 MR glucose metobolite mapping with the brain of an Altzheimer model mouse
- Principal Investigator
  
  Morikawa Shigehiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Shiga University of Medical Science
Development of fluorine-19 MRI probes to evaluate pathological features in Alzheimers diseasePrincipal Investigator
- Principal Investigator
  
  YANAGISAWA Daijiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Shiga University of Medical Science

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Patent

[Journal Article] Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes2024
- Author(s)
  Aldoghachi Asraa Faris、Yanagisawa Daijiro、Pahrudin Arrozi Aslina、Abu Bakar Zulzikry Hafiz、Taguchi Hiroyasu、Ishigaki Shinsuke、Morino Katsutaro、Tooyama Ikuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 694 Pages: 149392-149392
- DOI
  10.1016/j.bbrc.2023.149392
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07370, KAKENHI-PROJECT-23K28411
[Journal Article] An insight into the neuroprotective and anti-neuroinflammatory effects and mechanisms of Moringa oleifera2023
- Author(s)
  Azlan Ummi Kalthum、Khairul Annuar Nur Aisyah、Mediani Ahmed、Aizat Wan Mohd、Damanhuri Hanafi Ahmad、Tong Xiaohui、Yanagisawa Daijiro、Tooyama Ikuo、Wan Ngah Wan Zurinah、Jantan Ibrahim、Hamezah Hamizah Shahirah
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 13 Pages: 1035220-1035220
- DOI
  10.3389/fphar.2022.1035220
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07370
[Journal Article] アルツハイマー病の新規MRプローブ2023
- Author(s)
  遠山育夫、柳沢大治郎
- Journal Title
  
  医学のあゆみ
  
  Volume: 287 Pages: 985-990
- Data Source
  KAKENHI-PROJECT-23K28411
[Journal Article] Visualization of Amyloid Oligomers in the Brain of Patients with Alzheimer’s Disease2023
- Author(s)
  Tooyama Ikuo、Kato Tomoko、Taguchi Hiroyasu、Kageyama Yusuke、Irie Kazuhiro、Hirahara Yukie、Yanagisawa Daijiro
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 56 Issue: 6 Pages: 87-94
- DOI
  10.1267/ahc.23-00058
- ISSN
  0044-5991, 1347-5800
- Year and Date
  2023-12-28
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14689, KAKENHI-PROJECT-22K07370, KAKENHI-PROJECT-23H00325, KAKENHI-PROJECT-23K28411
[Journal Article] Immunohistochemical Analysis of Mitochondrial Ferritin in the Midbrain of Patients with Parkinson’s Disease2023
- Author(s)
  Tsubaki Haruka、Yanagisawa Daijiro、Kageyama Yusuke、Hafiz Abu Baker Zulzikry、Mukaisho Ken-ichi、Tooyama Ikuo
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 56 Issue: 2 Pages: 21-27
- DOI
  10.1267/ahc.22-00109
- ISSN
  0044-5991, 1347-5800
- Year and Date
  2023-04-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20588, KAKENHI-PROJECT-22K07370
[Journal Article] 第5土曜特集アルツハイマー病--研究と治療の最前線画像･AI アルツハイマー病の新規MRIプローブ2023
- Author(s)
  遠山育夫、柳沢大治郎
- Journal Title
  
  医学のあゆみ
  
  Volume: 287 Issue: 13 Pages: 985-990
- DOI
  10.32118/ayu28713985
- ISSN
  0039-2359
- Year and Date
  2023-12-30
- Open Access
- Data Source
  KAKENHI-PROJECT-22K07370
[Journal Article] Optimization of 3D Immunofluorescence Analysis and Visualization Using IMARIS and MeshLab2023
- Author(s)
  Abu Bakar Zulzikry Hafiz、Bellier Jean-Pierre、Wan Ngah Wan Zurinah、Yanagisawa Daijiro、Mukaisho Ken-ichi、Tooyama Ikuo
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 2 Pages: 218-218
- DOI
  10.3390/cells12020218
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07370
[Journal Article] Pharmaceutical Potential of Casein-Derived Tripeptide Met-Lys-Pro: Improvement in Cognitive Impairments and Suppression of Inflammation in APP/PS1 Mice2022
- Author(s)
  Matsuzaki Tada Asuka、Hamezah Hamizah Shahirah、Pahrudin Arrozi Aslina、Abu Bakar Zulzikry Hafiz、Yanagisawa Daijiro、Tooyama Ikuo
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 89 Issue: 3 Pages: 835-848
- DOI
  10.3233/jad-220192
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07370
[Journal Article] LC3/FtMt Colocalization Patterns Reveal the Progression of FtMt Accumulation in Nigral Neurons of Patients with Progressive Supranuclear Palsy2022
- Author(s)
  Abu Bakar Zulzikry Hafiz、Bellier Jean-Pierre、Yanagisawa Daijiro、Kato Tomoko、Mukaisho Ken-ichi、Tooyama Ikuo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 1 Pages: 537-537
- DOI
  10.3390/ijms23010537
- NAID
  120007183408
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08853, KAKENHI-PROJECT-22K07370, KAKENHI-PROJECT-20K20588
[Journal Article] Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibrils2021
- Author(s)
  Yanagisawa D, Kato T, Taguchi H, Shirai N, Hirao K, Sogabe T, Tomiyama T, Gamo K, Hirahara Y, Kitada M, Tooyama I
- Journal Title
  
  Biomaterials
  
  Volume: 270 Pages: 120686-120686
- DOI
  10.1016/j.biomaterials.2021.120686
- NAID
  120006959909
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06814, KAKENHI-PROJECT-19K12780, KAKENHI-PROJECT-19K20670, KAKENHI-PROJECT-17H03560
[Journal Article] A Fluorine-19 Magnetic Resonance Probe, Shiga-Y5, Downregulates Thioredoxin-Interacting Protein Expression in the Brain of a Mouse Model of Alzheimer’s Disease2021
- Author(s)
  Pahrudin Arrozi Aslina、Abu Bakar Zulzikry Hafiz、Taguchi Hiroyasu、Yanagisawa Daijiro、Tooyama Ikuo
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 17 Pages: 5342-5342
- DOI
  10.3390/molecules26175342
- NAID
  120007147812
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12780
[Journal Article] Nasal extracts from patients with Alzheimer’s disease induce tau aggregates in a cellular model of tau propagation.2021
- Author(s)
  slina Pahrudin Arrozi, Daijiro Yanagisawa, Tomoko Kato, Hiroyasu Akatsu, Yoshio Hashizume, Daita Kaneda, Ikuo Tooyama
- Journal Title
  
  Journal of Alzheimer’s Disease Reports
  
  Volume: 5 Issue: 1 Pages: 263-274
- DOI
  10.3233/adr-210298
- NAID
  120007028250
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20588, KAKENHI-PROJECT-19K20670
[Journal Article] Fluorine-19 Magnetic Resonance Imaging for Detection of Amyloid β Oligomers Using a Keto Form of Curcumin Derivative in a Mouse Model of Alzheimer’s Disease2021
- Author(s)
  Yanagisawa Daijiro、Ibrahim Nor Faeizah、Taguchi Hiroyasu、Morikawa Shigehiro、Tomiyama Takami、Tooyama Ikuo
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 5 Pages: 1362-1362
- DOI
  10.3390/molecules26051362
- NAID
  120007028249
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12780, KAKENHI-PROJECT-17H03560
[Journal Article] Novel fluorinated derivative of curcumin negatively regulates thioredoxin-interacting protein expression in retinal pigment epithelial and macrophage cells2020
- Author(s)
  Buyandelger Undral、Walker Douglas Gordon、Taguchi Hiroyasu、Yanagisawa Daijiro、Tooyama Ikuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 532 Issue: 4 Pages: 668-674
- DOI
  10.1016/j.bbrc.2020.08.114
- NAID
  120006887065
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12780, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-19K07843
[Journal Article] Effects of FTMT Expression by Retinal Pigment Epithelial Cells on Features of Angiogenesis2020
- Author(s)
  Buyandelger Undral、Walker Douglas G.、Yanagisawa Daijiro、Morimura Toshifumi、Tooyama Ikuo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 10 Pages: 3635-3635
- DOI
  10.3390/ijms21103635
- NAID
  120006862374
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-20K06391, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-19K07843
[Journal Article] Generation of transgenic cynomolgus monkeys overexpressing the gene for amyloid-β precursor protein2020
- Author(s)
  Seita Y, Morimura T, Watanabe N, Iwatani C, Tsuchiya H, Nakamura S, Suzuki T, Yanagisawa D, Tsukiyama T, Nakaya M, Okamura E, Muto M, Ema M, Nishimura M, Tooyama I.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: - Issue: 1 Pages: 45-60
- DOI
  10.3233/jad-191081
- NAID
  120006859791
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21585, KAKENHI-PROJECT-19H03546, KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17K08077, KAKENHI-PROJECT-17K08135, KAKENHI-PROJECT-17K17812, KAKENHI-PROJECT-20K21370, KAKENHI-PROJECT-19K16023, KAKENHI-PROJECT-20K16491, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-18H02566
[Journal Article] Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction.2019
- Author(s)
  Hamezah HS, Durani LW, Yanagisawa D, Ibrahim NF, Aizat WM, Makpol S, Wan Ngah WZ, Damanhuri HA, Tooyama I
- Journal Title
  
  Alzheimers Dis.
  
  Volume: 72 Issue: 1 Pages: 229-246
- DOI
  10.3233/jad-181171
- NAID
  120006768262
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-17K01355
[Journal Article] Proteome profiling in the hippocampus, medial prefrontal cortex, and striatum of aging rat2018
- Author(s)
  Hamezah Hamizah Shahirah、Durani Lina Wati、Yanagisawa Daijiro、Ibrahim Nor Faeizah、Aizat Wan Mohd、Bellier Jean Pierre、Makpol Suzana、Ngah Wan Zurinah Wan、Damanhuri Hanafi Ahmad、Tooyama Ikuo
- Journal Title
  
  Experimental Gerontology
  
  Volume: 111 Pages: 53-64
- DOI
  10.1016/j.exger.2018.07.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-18K08853, KAKENHI-PROJECT-17H03560
[Journal Article] Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y52018
- Author(s)
  Yanagisawa Daijiro、Hamezah Hamizah Shahirah、Durani Lina Wati、Taguchi Hiroyasu、Tooyama Ikuo
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 12 Pages: e0208440-e0208440
- DOI
  10.1371/journal.pone.0208440
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-15K01282
[Journal Article] Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice2018
- Author(s)
  Durani Lina Wati、Hamezah Hamizah Shahirah、Ibrahim Nor Faeizah、Yanagisawa Daijiro、Nasaruddin Muhammad Luqman、Mori Masaki、Azizan Kamalrul Azlan、Damanhuri Hanafi Ahmad、Makpol Suzana、Wan Ngah Wan Zurinah、Tooyama Ikuo
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 64 Issue: 1 Pages: 249-267
- DOI
  10.3233/jad-170880
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17H03560
[Journal Article] DJ-1/PARK7: A New Therapeutic Target for Neurodegenerative Disorders2017
- Author(s)
  Hijioka Masanori、Inden Masatoshi、Yanagisawa Daijiro、Kitamura Yoshihisa
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 5 Pages: 548-552
- DOI
  10.1248/bpb.b16-01006
- NAID
  130005631951
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-16H07341
[Journal Article] Effects of a DJ-1-binding compound on spatial learning and memory impairment in a mouse model of Alzheimer's disease2017
- Author(s)
  Kitamura Y, Inden M, Kimoto K, Takata K, Yanagisawa D, Hijioka M, Ashihara K, Tooyama I, Shimohama S, Ariga H
- Journal Title
  
  Journal of Alzheimer’s Disease
  
  Volume: 55 Issue: 1 Pages: 67-72
- DOI
  10.3233/jad-160574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K16321, KAKENHI-PROJECT-16K08286, KAKENHI-PROJECT-16H05279
[Journal Article] Tocotrienol-rich fraction modulates amyloid pathology and improves cognitive function in AβPP/PS1 mice.2017
- Author(s)
  Ibrahim NF, Yanagisawa D, Durania LW, Hamezaha HS, HDamanhuri HD, Wan Ngahb WZ, Tsuji M, Kiuchi Y, Ono K, Tooyama I
- Journal Title
  
  Journal of Alzheiemrs Disease
  
  Volume: 55 Issue: 2 Pages: 597-617
- DOI
  10.3233/jad-160685
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26461266, KAKENHI-PROJECT-15K16321
[Journal Article] Fluorine-19 magnetic resonance imaging probe for the detection of tau pathology in female rTg4510 mice2017
- Author(s)
  Yanagisawa Daijiro、Ibrahim Nor Faeizah、Taguchi Hiroyasu、Morikawa Shigehiro、Kato Tomoko、Hirao Koichi、Shirai Nobuaki、Sogabe Takayuki、Tooyama Ikuo
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume: 96 Issue: 5 Pages: 841-851
- DOI
  10.1002/jnr.24188
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282, KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17K01563, KAKENHI-PROJECT-26282145, KAKENHI-PROJECT-17H03560
[Journal Article] Fluorodopa is a promising fluorine-19 MRI probe for evaluating striatal dopaminergic function in a rat model of Parkinson’s disease.2017
- Author(s)
  Yanagisawa D, Oda K, Inden M, Morikawa S, Inubushi T, Taniguchi T, Hijioka M, Kitamura Y, Tooyama I
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume: 印刷中 Issue: 7 Pages: 1485-1494
- DOI
  10.1002/jnr.23983
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-15K16321
[Journal Article] Age-related changes in the metabolic profiles of rat hippocampus, medial prefrontal cortex and striatum2017
- Author(s)
  Durani Lina Wati、Hamezah Hamizah Shahirah、Ibrahim Nor Faeizah、Yanagisawa Daijiro、Makpol Suzana、Damanhuri Hanafi Ahmad、Tooyama Ikuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 493 Issue: 3 Pages: 1356-1363
- DOI
  10.1016/j.bbrc.2017.09.164
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17H03560
[Journal Article] Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions2017
- Author(s)
  Hamezah Hamizah Shahirah、Durani Lina Wati、Ibrahim Nor Faeizah、Yanagisawa Daijiro、Kato Tomoko、Shiino Akihiko、Tanaka Sachiko、Damanhuri Hanafi Ahmad、Ngah Wan Zurinah Wan、Tooyama Ikuo
- Journal Title
  
  Experimental Gerontology
  
  Volume: 99 Pages: 69-79
- DOI
  10.1016/j.exger.2017.09.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17H03560
[Journal Article] Mitochondrial ferritin affects mitochondria by stabilizing HIF-1α in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration2016
- Author(s)
  Wang X, Yang H, Yanagisawa D, Bellier JP, Morino K, Zhao S, Liu P, Vigers P, Tooyama I
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 47 Pages: 168-179
- DOI
  10.1016/j.neurobiolaging.2016.07.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K16321
[Journal Article] Inhibition of monocarboxylate transporter 1 suppresses the proliferation of glioblastoma stem cells.2016
- Author(s)
  Takada T, Takata K, Ashihara E.
- Journal Title
  
  J Physiol Sci
  
  Volume: 66 Pages: 74-81
- DOI
  10.1016/j.neuint.2016.02.008
- NAID
  40020922534
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461436, KAKENHI-PROJECT-26860058, KAKENHI-PROJECT-25460109, KAKENHI-PROJECT-16H05279, KAKENHI-PROJECT-15K16321
[Journal Article] Therapeutic effects of mesenchymal stem cells for Parkinson’s disease2016
- Author(s)
  Inden M, Yanagisawa D, Hijioka M, Kitamura Y
- Journal Title
  
  Annals of Neurodegenerative Disorders
  
  Volume: 1 Pages: 1002-1002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K16321
[Journal Article] Amyloid imaging using fluorine-19 magnetic resonance imaging (19F-MRI).2016
- Author(s)
  Tooyama I, Yanagisawa D, Taguchi H, Kato T, Hirao K, Shirai N, Sogabe T, Ibrahim NF, Inubushi T, Morikawa S
- Journal Title
  
  Ageing Research Reviews
  
  Volume: 15 Pages: 1568-1637
- DOI
  10.1016/j.arr.2015.12.008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K01282, KAKENHI-PROJECT-15K16321, KAKENHI-PUBLICLY-26111709, KAKENHI-PROJECT-24240071, KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26282145
[Journal Article] Up-regulation of mitochondrial ferritin by proinflammatory cytokines: Implications for a role in Alzheimer’s disease.2015
- Author(s)
  Yang H, Guan H, Yang M, Liu Z, Takeuchi S, Yanagisawa D, Vincent SR, Zhao S, Tooyama I
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 45 Issue: 3 Pages: 797-811
- DOI
  10.3233/jad-142595
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-26111709, KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26670554
[Journal Article] Novel curcumin derivatives as potent inhibitors of amyloid β aggregation2015
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Kato T, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 4 Pages: 357-368
- DOI
  10.1016/j.bbrep.2015.10.009
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16321, KAKENHI-PROJECT-26670554
[Journal Article] Inhalable Curcumin: Offering the Potential for Translation to Imaging and Treatment of Alzheimer's Disease.2014
- Author(s)
  McClure R, Yanagisawa D, Stec D, Koktysh D, Xhillari D, Jaeger R, Chekmenev E, Tooyama I, Gore1 JC, Pham W
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 144 Issue: 1 Pages: 283-295
- DOI
  10.3233/jad-140798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-26111709, KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26670554
[Journal Article] Synthesis and Tautomerism of Curcumin Derivatives and Related Compounds2014
- Author(s)
  Taguchi H, Yanagisawa D, Morikawa S, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Australian Journal of Chemistry
  
  Volume: 68 Issue: 2 Pages: 224-229
- DOI
  10.1071/ch14464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24240020, KAKENHI-PROJECT-25750159, KAKENHI-PROJECT-26670554, KAKENHI-PROJECT-26282145
[Journal Article] Curcumin derivative with substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PSI mice2014
- Author(s)
  Yanagisawa D, Ibraham NF, Taguchi H, Morikawa S, Hirao K, Shirai N, Sogabe T, Tooyama I
- Journal Title
  
  Neurobiol Aging
  
  Volume: 36 Issue: 1 Pages: 210-210
- DOI
  10.1016/j.neurobiolaging.2014.07.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24240020, KAKENHI-PROJECT-25750159, KAKENHI-PUBLICLY-26111709, KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26670554, KAKENHI-PROJECT-26282145
[Journal Article] Preferred features of a fluorine-19 MRI probe foramyloid detection in the brain2014
- Author(s)
  Yanagisawa D, Taguchi H, Ibrahim NF, Morikawa S, Shiino A, Inubushi T, Hirao K, Shirai N, Sogabe T, Toovama I
- Journal Title
  
  J AIzhei mer's Dis
  
  Volume: 39 Issue: 3 Pages: 617-631
- DOI
  10.3233/jad-131025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153, KAKENHI-PROJECT-23300188, KAKENHI-PUBLICLY-24111522, KAKENHI-PROJECT-24240020, KAKENHI-PROJECT-24240071, KAKENHI-PROJECT-25750159
[Patent] アミロイドオリゴマーの画像診断薬2020
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎、加藤智子
- Industrial Property Rights Holder
  遠山育夫、田口弘康、柳沢大治郎、加藤智子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-033405
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K12780
[Patent] 神経難病の画像診断薬及び体外診断薬2017
- Inventor(s)
  遠山育夫、柳沢大治郎、田口弘康、曾我部孝行、白井伸明、平尾浩一
- Industrial Property Rights Holder
  滋賀医科大学、滋賀県、大塚製薬株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-046350
- Filing Date
  2017-03-10
- Data Source
  KAKENHI-PROJECT-15K16321
[Patent] 神経難病のMR画像診断薬2014
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Holder
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Type
  特許
- Filing Date
  2014-01-06
- Overseas
- Data Source
  KAKENHI-PROJECT-25750159
[Patent] 神経難病のMR画像診断薬2013
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Holder
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-202531
- Filing Date
  2013-09-27
- Data Source
  KAKENHI-PROJECT-25750159
[Presentation] APPトランスジェニックカニクイザルの開発：脳脊髄液バイオマーカー2023
- Author(s)
  柳沢大治郎、守村敏史、西村正樹、遠山育夫、依馬正次、石垣診祐
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07370
[Presentation] 鼻粘膜に存在する認知症原因タンパクのプリオン活性を利用した診断法の検討2023
- Author(s)
  遠山育夫, Aslina Pahrudin Arrozi, ○柳沢大治郎, 水上民夫, 金田大太
- Organizer
  第50回日本脳科学会
- Data Source
  KAKENHI-PROJECT-22K07370
[Presentation] 鼻粘膜に存在する認知症原因タンパクのプリオン活性を利用した診断法の検討2023
- Author(s)
  遠山育夫、Aslina Pahrudin Arrozi、柳沢大治郎、水上民夫、金田大太
- Organizer
  第50回日本脳科学会
- Data Source
  KAKENHI-PROJECT-20K20588
[Presentation] ケト型クルクミン誘導体Shiga-Y51はアミロイドβオリゴマーに選択的に結合する2023
- Author(s)
  柳沢大治郎、加藤智子、田口弘康、平原幸恵、北田容章、遠山育夫
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-22K07370
[Presentation] Reciprocal F1 hybrids of rTg4510 mice show a difference in pathological tau accumulation in the brain2023
- Author(s)
  Daijiro Yanagisawa, Shinsuke Ishigaki, Ikuo Tooyama
- Organizer
  Society for Neuroscience’s Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07370
[Presentation] Detection of abnormal protein aggregates in Alzheimer’s disease using magnetic resonance imaging2022
- Author(s)
  Daijiro Yanagisawa, Ikuo Tooyama
- Organizer
  The 30th Annual Meeting of Malaysian Society of Neurosciences 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07370
[Presentation] フッ素MRIによるアミロイドβ・タウ病理の画像化研究2021
- Author(s)
  柳沢大治郎, 田口弘康, 遠山育夫
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K12780
[Presentation] タウ遺伝子改変マウスrTg4510のタウ蓄積における遺伝的背景の影響2019
- Author(s)
  柳沢大治郎、Hamizah Shahirah Hamezah、Aslina Pahrudin Arrozi、田口弘康、遠山育夫
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K12780
[Presentation] Therapeutic effects of a curcumin derivative Shiga-Y5 in the brain of a mouse model of Alzheimer’s disease2019
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  The 13th Japan-China Joint Seminar on Histochemistry and Cytochemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355
[Presentation] rTg4510マウスのタウ蓄積量を変動させる因子の探索2019
- Author(s)
  柳沢大治郎、Hamizah Shahirah Hamezah、Aslina Pahrudin Arrozi、遠山育夫
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-17K01355
[Presentation] タウ遺伝子改変マウスrTg4510のタウ蓄積における遺伝的背景の影響2019
- Author(s)
  柳沢大治郎、Hamizah Shahirah Hamezah、Aslina Pahrudin Arrozi、田口弘康、遠山育夫
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K01355
[Presentation] Therapeutic effects of a curcumin derivative Shiga-Y5 in the brain of a mouse model of Alzheimer’s disease2019
- Author(s)
  柳沢大治郎、田口弘康、遠山育夫
- Organizer
  The 13th Japan-China Joint Seminar on Histochemistry and Cytochemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12780
[Presentation] Detection of abnormal protein accumulation in Alzheimer’s disease using magnetic resonance imaging2018
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  The 5th Annual Meeting of Mongolian Neuroscience Society MULTIDISCIPLINARY BRAIN SCIENCE 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355
[Presentation] Curcumin derivative with C-4 substituent attenuated amyloid deposition, but did not affect tau pathology in mouse models2018
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Lina Wati Durani, Hamizah Shahirah, Hamezah, Ikuo Tooyama
- Organizer
  Alzheimer’s Association International Conference 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355
[Presentation] クルクミン誘導体Shiga-Y5はAβの蓄積を抑制するが、タウの蓄積には作用しない2018
- Author(s)
  柳沢大治郎、Hamizah Shahirah Hamezah、田口弘康、遠山育夫
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K01355
[Presentation] Fluorine-19 magnetic resonance imaging to detect tau pathology in rTg4510 mice2018
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Shigehiro Morikawa, Ikuo Tooyama
- Organizer
  The 18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355
[Presentation] フッ素MRIによる脳内タウ凝集体の検出2018
- Author(s)
  柳沢大治郎、田口弘康、森川茂廣、加藤智子、遠山育夫
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K01355
[Presentation] MRIによるタウ病変の検出法の開発2018
- Author(s)
  柳沢大治郎、田口弘康、遠山育夫
- Organizer
  第45回日本脳科学会
- Data Source
  KAKENHI-PROJECT-17K01355
[Presentation] In vivo detection of tau pathology by fluorine-19 MR imaging in a mouse model of tauopathy2017
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Ikuo Tooyama
- Organizer
  第12回日本分子イメージング学会学術集会
- Data Source
  KAKENHI-PROJECT-17K01355
[Presentation] フッ素MRIによるタウ病変のイメージング2017
- Author(s)
  柳沢大治郎、田口弘康、森川茂廣、遠山育夫
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K01355
[Presentation] In vivo detection of tau pathology by fluorine-19 MR imaging in a mouse model of tauopathy2017
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Ikuo Tooyama
- Organizer
  第12回日本分子イメージング学会学術集会
- Place of Presentation
  横浜港　大さん橋ホール
- Data Source
  KAKENHI-PROJECT-15K16321
[Presentation] Tau imaging using fluorine-19 MRI in a mouse model of tauopathy2017
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Ikuo Tooyama
- Organizer
  Alzheimer’s Association International Conference on Alzheimer’s Disease 2017
- Place of Presentation
  イギリス・ロンドン
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16321
[Presentation] Keto-enol tautomerism of curcumin upon binding to amyloid fibrils2017
- Author(s)
  Daijiro Yanagisawa
- Organizer
  第55回日本生物物理学会
- Data Source
  KAKENHI-PROJECT-17K01355
[Presentation] Tau imaging using fluorine-19 MRI in a mouse model of tauopathy2017
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Ikuo Tooyama
- Organizer
  Alzheimer’s Association International Conference 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01355
[Presentation] フッ素MR画像化法によるAβオリゴマーの検出の開発2016
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-15K16321
[Presentation] アルツハイマー病の病態解明のためのフッ素MRIによるダブルプローブイメージング法の開発2016
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第11回日本分子イメージング学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-15K16321
[Presentation] Effects of Novel Curcumin Derivative with C-4 Substituent on Cognitive Impairment and Amyloid Deposition in Appswe/PS1dE9 Mice2015
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Hiroyasu Taguchi, Shigehiro Morikawa, Koichi Hirao, Nobuaki Shirai, Ikuo Tooyama
- Organizer
  Alzheimer’s Association International Conference on Alzheimer’s Disease 2015
- Place of Presentation
  Washington DC, USA
- Year and Date
  2015-07-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16321
[Presentation] フッ素MRIを利用したAβオリゴマーの画像化法の開発2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第10回日本分子イメージング学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] クルクミン誘導体によるアミロイドβ凝集抑制作用の解析2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、Lina Wati Durani、Hamizah Shahirah Hamezah、田口弘康、遠山育夫
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] Effects of Novel Curcumin Derivative with C-4 Substituent on Cognitive Impairment and Amyloid Deposition in Appswe/PS1dE9 Mice.2015
- Author(s)
  Yanagisawa D, Ibrahim NF, Durani LW, Hamezah HS, Taguchi H, Morikawa S, Hirao K, Shirai N, Tooyama I.
- Organizer
  Alzheimer’s Association International Conference on Alzheimer’s Disease 2015,
- Place of Presentation
  Washington DC, USA
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] Shiga-Y5 is a potential diagnostic and therapeutic agent for Alzheimer’s disease2015
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  新学術領域脳内環境-恒常性維持機構とその破綻-第2回若手研究者によるシンポジウム
- Place of Presentation
  広島大学広仁会館
- Year and Date
  2015-01-08
- Data Source
  KAKENHI-PROJECT-25750159
[Presentation] フッ素MRIを利用したAβオリゴマーの画像化法の開発2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第10回日本分子イメージング学会学術集会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15K16321
[Presentation] クルクミン誘導体によるアミロイドβ凝集抑制作用の解析2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、Lina Wati Durani、Hamizah Shahirah Hamezah、田口弘康、遠山育夫
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2015-07-30
- Data Source
  KAKENHI-PROJECT-15K16321
[Presentation] Amyloid detection using fluorine-19 MRI in the transgenic mouse model of AD2014
- Author(s)
  Daijiro Yanagisawa
- Organizer
  18th MNRC International Symposium
- Place of Presentation
  滋賀医科大学
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-25750159
[Presentation] Novel curcumin derivative with C-4 substituent inhibits amyloid pathology in APPswe/PS1dE9 mice2014
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Nor Faeizah Ibrahim, Lina Wati Durani, Shigehiro Morikawa, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Ikuo Tooyama
- Organizer
  Society for Neuroscience’s 44th Annual Meeting
- Place of Presentation
  Washington DC, アメリカ合衆国
- Year and Date
  2014-11-16
- Data Source
  KAKENHI-PROJECT-25750159
[Presentation] アルツハイマー病治療効果を示す新規クルクミン誘導体の開発2014
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、遠山育夫
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-12
- Data Source
  KAKENHI-PROJECT-25750159
[Presentation] クルクミン誘導体によるAβ凝集抑制効果とAβによる細胞障害軽減効果の解析2014
- Author(s)
  柳沢大治郎、遠山育夫、Nor Faeizah Ibrahim、田口弘康
- Organizer
  第11回認知症サプリメント研究会
- Place of Presentation
  AP品川
- Year and Date
  2014-10-04
- Invited
- Data Source
  KAKENHI-PROJECT-25750159
[Presentation] Required features of a fluorine-19 MRI probe for amyloid detection in the brain2013
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Shigehiro Morikawa, Akihiko Shiino, Toshiro Inubushi, Nor Faeizah Ibrahim, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Ikuo Tooyama
- Organizer
  Alzheimer’s Association 2013 International Conference on Alzheimer’s Disease
- Place of Presentation
  米国ボストン
- Data Source
  KAKENHI-PROJECT-25750159
[Presentation] アルツハイマー病画像診断を目的とした19F MRIによる脳内アミロイド斑の検出（その2）2013
- Author(s)
  柳沢大治郎、田口弘康、森川茂廣、椎野顯彦、犬伏俊郎、Ibrahim Nor Faeizah、遠山育夫
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25750159
[Presentation] 高磁場MR 装置を利用したフッ素MRI アミロイドイメージングのためのstyrylbenzoxazole 誘導体の開発
- Author(s)
  柳沢大治郎、田口弘康、森川茂廣、椎野顯彦、犬伏俊郎、遠山育夫
- Organizer
  第9回日本分子イメージング学会学術集会
- Place of Presentation
  豊中市
- Year and Date
  2014-05-22 – 2014-05-23
- Data Source
  KAKENHI-PROJECT-26670554
[Presentation] 高磁場MR装置を利用したフッ素MRIアミロイドイメージングのためのstyrylbenzoxazole誘導体の開発
- Author(s)
  柳沢大治郎、田口弘康、森川茂廣、椎野顯彦、犬伏俊郎、遠山育夫
- Organizer
  第9回日本分子イメージング学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター
- Year and Date
  2014-05-22 – 2014-05-23
- Data Source
  KAKENHI-PROJECT-25750159
[Presentation] 高磁場MR装置を利用したアルツハイマー病画像診断法の開発
- Author(s)
  柳沢大治郎
- Organizer
  2014年度創薬科学フロンティアシンポジウム
- Place of Presentation
  京都薬科大学
- Year and Date
  2014-11-23 – 2014-11-24
- Invited
- Data Source
  KAKENHI-PROJECT-25750159
[Presentation] アルツハイマー病遺伝子改変マウスにおける新規クルクミン誘導体の治療効果の解析
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、Lina Wati Durani、田口弘康、遠山育夫
- Organizer
  第33回日本認知症学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-25750159
[Presentation] Novel curcumin derivative with C-4 substituent inhibits amyloid pathology in APPswe/PS1dE9 mice.
- Author(s)
  Yanagisawa D, Taguchi H, Ibrahim N, Durani L, Morikawa S, Hirao K, Shirai N, Sogabe T, Tooyama I.
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington, D. C., United States of America
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26670554

1. TOOYAMA Ikuo (20207533)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
2. Morikawa Shigehiro (60220042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. Taguchi Hiroyasu (90102912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. 加藤智子 (90754367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 赤津裕康 (00399734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 水上民夫 (80367896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 金田大太 (40564795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 森野勝太郎 (90444447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KURUMI Yosimasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. TAKADA TESTUYA

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 北田容章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 平井慎一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. BELLIER Jean-Pierre

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 芦原英司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 犬伏俊郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 西村正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yanagisawa Daijiro 柳沢 大治郎

YANAGISAWA Daijiro 柳沢 大治郎

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認知症タウ病理の抑制を目的とした新規治療標的の創出Principal Investigator

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Simultaneous analysis of multiple abnormal brain proteins in Alzheimer's disease using multiple fluorine MR imaging

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Study of the role of MID1 in tauopathies and its application as a therapeutic targetPrincipal Investigator

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Role of microRNAs in the regulation of mitochondrial function to sarcopenia and cognitive function.

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Development of AI technology to detect prion activity of pathogenic proteins in nasal mucosa and its application to diagnosis of dementia

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Development of novel ligands for in vivo imaging of amyloid oligomers in the brain of Alzheimer's disease

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Evaluation of the progression of pathological changes in Alzheimer's disease using MRIPrincipal Investigator

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Double-probe imaging for simultaneous detection of amyloid and tau using fluorine-19 MRIPrincipal Investigator

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Study of a highly sensitive C-13 MR glucose metobolite mapping with the brain of an Altzheimer model mouse

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Development of fluorine-19 MRI probes to evaluate pathological features in Alzheimers diseasePrincipal Investigator

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[Journal Article] Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes2024

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[Journal Article] An insight into the neuroprotective and anti-neuroinflammatory effects and mechanisms of Moringa oleifera2023

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[Journal Article] アルツハイマー病の新規MRプローブ2023

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[Journal Article] Visualization of Amyloid Oligomers in the Brain of Patients with Alzheimer’s Disease2023

Yanagisawa Daijiro 柳沢大治郎

YANAGISAWA Daijiro 柳沢大治郎

[Journal Article] 第5土曜特集アルツハイマー病--研究と治療の最前線画像･AI アルツハイマー病の新規MRIプローブ2023