Hirota Yuko 廣田有子

… Alternative Names

HIROTA Yuko 廣田有子

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Researcher Number	50588259
Other IDs
Affiliation (Current)	2025: 九州大学, 薬学研究院, 助教
Affiliation (based on the past Project Information) *help	2024: 九州大学, 薬学研究院, 助教 2020 – 2022: 九州大学, 薬学研究院, 助教 2016 – 2017: 九州大学, 薬学研究院, 助教 2015: 九州大学, 薬学研究科(研究院), 助教 2013: 九州大学, 薬学研究科(研究院), 助教 … More 2012: 九州大学, 医学(系)研究科(研究院), 研究員 2011: 九州大学, 医学(系)研究科(研究院), 助教 2011: 九州大学, 大学院・医学研究院, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / General medical chemistry / Pathological medical chemistry Except Principal Investigator Medium-sized Section 63:Environmental analyses and evaluation and related fields / Environmental impact assessment / Biological pharmacy
Keywords	Principal Investigator リソソーム / 膜タンパク質 / 多剤耐性 / LAPTM4b / リソソーム膜タンパク質 / 抗がん剤 / トランスゴルジネットワーク / 小胞輸送 / エンドソーム / ミトコンドリア / マイトファジー / オートファジー … More Except Principal Investigator … More 環境化学物質 / 次世代影響 / ダイオキシン / 薬学 / 環境 / 有害化学物質 / 環境汚染物質 / 発育障害 / プロラクチン / 成長ホルモン / 黄体形成ホルモン / 低分子量GTP結合蛋白質 / オートファジ / 低分子量GTP結合タンパク質 / 生体分子 / 細胞・組織 / Rab32 / GTP結合タンパク質 / タンパク質分解 / リソソーム / オートファジー Less

内外環境の破綻による次世代影響評価：発達障害と性未成熟の機構の検証と予防
- Principal Investigator
  
  石井祐次
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  Kyushu University
Mechanism of multidrug resistance acquisition by lysosomal membrane protein LAPTM4bPrincipal Investigator
- Principal Investigator
  
  Hirota Yuko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kyushu University
Assessment of the impact of the disturbance in endo-and-xeno environment on the next-generation: study on the mechanism for sexual immaturity and developmental disorders and the preventive method
- Principal Investigator
  
  Ishii Yuji
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Environmental impact assessment
- Research Institution
  Kyushu University
Lysosomal membrane protein LAPTM4a functions in multiple drug resistance.Principal Investigator
- Principal Investigator
  
  Hirota Yuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyushu University
Comprehensive identification and function analysis of new autophagy-related genes using fly cultured cellsPrincipal Investigator
- Principal Investigator
  
  HIROTA Yuko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyushu University
Analysis of molecular mechanism of autophagy by GTP-binding protein Rab32
- Principal Investigator
  
  TANAKA Yoshitaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyushu University

All 2022 2021 2020 2016 2014 2013 2012 2011 2010 2009

All Journal Article Presentation Book

[Book] Autophagy-A Double-Edged Sword-Cell Survival or Death- Rab GTPases in Autophagy2013
- Author(s)
  Hirota, Y., Fujimoto, K., and Tanaka, Y.
- Total Pages
  18
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-23790371
[Book] Autophagy2013
- Author(s)
  Hirota Y.
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-23790371
[Book] Autophagy - A Double-Edged Sword - Cell Survival or Death? "Rab GTPases in Autophagy"2013
- Author(s)
  Yuko Hirota, Fujimoto Keiko, Yoshitaka Tanaka
- Total Pages
  18
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-23790371
[Journal Article] Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A42022
- Author(s)
  Miyauchi Yuu、Kimura Akane、Sawai Madoka、Fujimoto Keiko、Hirota Yuko、Tanaka Yoshitaka、Takechi Shinji、Mackenzie Peter I.、Ishii Yuji
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 13
- DOI
  10.3389/fphar.2022.832931
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16045, KAKENHI-PROJECT-20K07199
[Journal Article] LAPTM4α is targeted from the Golgi to late endosomes/lysosomes in a manner dependent on the E3 ubiquitin ligase Nedd4-1 and ESCRT proteins2021
- Author(s)
  Hirota Yuko、Hayashi Masaharu、Miyauchi Yuu、Ishii Yuji、Tanaka Yoshitaka、Fujimoto Keiko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 556 Pages: 9-15
- DOI
  10.1016/j.bbrc.2021.03.151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07199
[Journal Article] DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis2021
- Author(s)
  Chen Hong-bin、Pineda Garcia Jorge Carlos、Arizono Shinako、Takeda Tomoki、Li Ren-shi、Hattori Yukiko、Sano Hiroe、Miyauchi Yuu、Hirota Yuko、Tanaka Yoshitaka、Ishii Yuji
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 18532-18532
- DOI
  10.1038/s41598-021-97961-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07199
[Journal Article] HM1.24/BST-2 is constitutively poly-ubiquitinated at the N-terminal amino acid in the cytoplasmic domain2020
- Author(s)
  Fujimoto Keiko、Nakashima Sanae、Uchida Shotaro、Amen Riham N.S.、Ishii Yuji、Hirota Yuko、Tanaka Yoshitaka
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 23 Pages: 100784-100784
- DOI
  10.1016/j.bbrep.2020.100784
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07199
[Journal Article] Lysosomal integral membrane protein LGP85 (LIMP-2) is ubiquitinated at the N-terminal cytoplasmic domain2020
- Author(s)
  Fujimoto Keiko、Uchida Shotaro、Amen Riham N.S.、Ishii Yuji、Tanaka Yoshitaka、Hirota Yuko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 524 Issue: 2 Pages: 424-430
- DOI
  10.1016/j.bbrc.2020.01.095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07199
[Journal Article] The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A92020
- Author(s)
  Miyauchi Yuu、Kurohara Ken、Kimura Akane、Esaki Madoka、Fujimoto Keiko、Hirota Yuko、Takechi Shinji、Mackenzie Peter I.、Ishii Yuji、Tanaka Yoshitaka
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 35 Issue: 5 Pages: 466-474
- DOI
  10.1016/j.dmpk.2020.07.006
- NAID
  50014592888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07199
[Journal Article] Intracellular dynamics and fate of a humanized anti-Interleukin-6 receptor monoclonal antibody, Tocilizumab.2016
- Author(s)
  Fujimoto, K., Ida, H., Hirota, Y., Ishigai, M., Amano, J., and Tanaka, Y.
- Journal Title
  
  Molecular Pharmcology
  
  Volume: 88 Issue: 4 Pages: 660-675
- DOI
  10.1124/mol.115.099184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19010
[Journal Article] The Tor and Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg322014
- Author(s)
  Aihara, M., Jin, X., Kurihara, Y., Yoshida, Y., Matsushima, Y., Oku, M., Hirota, Y., Saigusa, T., Aoki, Y., Uchiumi, T., Yamamoto, T., Sakai, Y., Kang, D., and Kanki, T.
- Journal Title
  
  J. Cell Sci
  
  Volume: (In Press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790371
[Journal Article] The Tor and Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg322014
- Author(s)
  Masamune Aihara, Xiulian Jin, Yusuke Kurihara, Yutaka Yoshida, Yuichi Matsushima, Masahide Oku, Yuko Hirota, Tetsu Saigusa, Yoshimasa Aoki, Takeshi Uchiumi, Tadashi Yamamoto, Yasuyoshi Sakai, Dongchon Kang, and Tomotake Kanki
- Journal Title
  
  Journal of Cell Science
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790371
[Journal Article] Casein kinase 2 is essential for mitophagy.2013
- Author(s)
  Kanki T., Kurihara Y., Jin X., Goda T., Ono Y., Aihara M., Hirota Y., Saigusa T., Aoki Y., Uchiumi T., Kang D.
- Journal Title
  
  EMBO reports
  
  Volume: 14巻 Issue: 9 Pages: 788-794
- DOI
  10.1038/embor.2013.114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J04836, KAKENHI-PROJECT-23689032, KAKENHI-PROJECT-23790371, KAKENHI-PROJECT-24659281, KAKENHI-PROJECT-24790556, KAKENHI-PUBLICLY-25117714, KAKENHI-PROJECT-25253041, KAKENHI-PROJECT-25560414
[Journal Article] The physiological role of mitophagy: new insights into phosphorylation events.2012
- Author(s)
  Hirota, Y., Kang, D., Kanki, T.
- Journal Title
  
  International journal of cell biology
  
  Volume: 2012 Pages: 354914-354914
- DOI
  10.1155/2012/354914
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249018, KAKENHI-PROJECT-23689032, KAKENHI-PROJECT-23790371, KAKENHI-PROJECT-24659281, KAKENHI-PUBLICLY-23117712
[Journal Article] Mitophagy plays an essential role in reducing mitochondrial production of reactive oxygen species and mutation of mitochondrial DNA by maintaining mitochondrial quantity and quality in yeast2012
- Author(s)
  Kurihara Y, Kanki T, Aoki Y, Hirota Y, Saigusa T, Uchiumi T, Kang D
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 5 Pages: 3265-3272
- DOI
  10.1074/jbc.m111.280156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590337, KAKENHI-PUBLICLY-22020028, KAKENHI-PROJECT-22249018, KAKENHI-PUBLICLY-23117712, KAKENHI-PROJECT-23689032, KAKENHI-PROJECT-23790371, KAKENHI-PROJECT-24659281
[Journal Article] Phosphorylation of Serine 114 on Atg32 mediates mitophagy2011
- Author(s)
  Aoki, Y., Kanki, T., Hirota, Y., Kurihara, Y., Saigusa, T., Uchiumi, T., Kang, D.
- Journal Title
  
  Mol Biol Cell
  
  Volume: 22 Issue: 17 Pages: 3206-3217
- DOI
  10.1091/mbc.e11-02-0145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659148, KAKENHI-PUBLICLY-22020028, KAKENHI-PUBLICLY-23117712, KAKENHI-PROJECT-23689032, KAKENHI-PROJECT-23790371
[Journal Article] Antigen-dependent internalization is related to rapid elimination from plasma of humanized anti-HM1. 24 monoclonal antibody(AHM)2010
- Author(s)
  Amano J., Masuyama N., Hirota Y., Tanaka Y., Igawa Y., Shiokawa R., Okutani T., Miyayama T., Nanami M., and Ishigai M.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 38 Pages: 2339-2346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590065
[Journal Article] Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin432010
- Author(s)
  Ozono C., Etoh S., Matsumoto M., Nakayama K., Hirota Y., Tanaka Y., and Fujita H.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 33 Pages: 951-957
- NAID
  130000247960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590065
[Journal Article] A small GTPase, human Rab32, is required for the formation of autophagic vacuoles under basal conditions2009
- Author(s)
  Hirota Y. and Tanaka Y
- Journal Title
  
  Cell. Mol. Life Sci.
  
  Volume: 66 Pages: 2913-2932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590065
[Journal Article] A small GTPase. human Rab32, is required for the formation of autophagic vacuoles under basal conditions2009
- Author(s)
  Hirota, Y., Tanaka, Y.
- Journal Title
  
  Cell.Mol.Life Sci. 66
  
  Pages: 2913-2932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590065
[Journal Article] HM1. 24 is internalized from lipid rafts by clathrin-mediated endocytosis through interaction with alpha-adaptin2009
- Author(s)
  Masuyama N., Kuronita T., Tanaka R., Muto T., Hirota Y., Takigawa A., Fujita H., Aso Y., Amano J., and Tanaka Y.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 284 Pages: 15927-15941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590065
[Presentation] Death associated protein-like 1 (DAPL1) の特性検討：細胞内局在およびテストステロン産生調節作用2022
- Author(s)
  陳　宏斌、有園　詩奈子、廣田有子、宮内　優、田中　嘉孝、石井　祐次
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07199
[Presentation] ESCRT非依存的分解経路によるLAPTM4αの細胞内動態2022
- Author(s)
  津森　良士、河野　佑輔、藤本　景子、石井　祐次、田中　嘉孝、廣田　有子
- Organizer
  第74回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-20K07199
[Presentation] 新規シトクロムP450 3A4 発現系の構築:バキュロウイルスを用いた COS-1細胞における過剰発現2021
- Author(s)
  宮内優、木村茜、江﨑円香、藤本景子、廣田有子、武知進士、石井祐次、田中嘉孝
- Organizer
  日本薬学会　第１４１年回
- Data Source
  KAKENHI-PROJECT-20K07199
[Presentation] ESCRTタンパク質Hrsによるリソソーム膜タンパク質LAPTMαの細胞内輸送制御機構2021
- Author(s)
  河野　祐輔、藤本　景子、石井　祐次、田中　嘉孝、廣田　有子
- Organizer
  第73回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-20K07199
[Presentation] ミトコンドリア分解シグナルの解明2013
- Author(s)
  廣田有子、栗原悠介、金秀蓮、三枝徹、藤本景子、田中嘉孝、神吉智丈
- Organizer
  生体機能と創薬シンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23790371
[Presentation] ミトコンドリア分解シグナルの解明生体機能と創薬2013
- Author(s)
  廣田有子、栗原悠介、金秀蓮、三枝徹、藤本景子、田中嘉孝、神吉智丈
- Organizer
  シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2013-08-29
- Data Source
  KAKENHI-PROJECT-23790371
[Presentation] The participation of mitophagy -related genes to phosphorylation events of Atg322012
- Author(s)
  金秀蓮、神吉智丈、相原正宗、栗原悠介、廣田有子、三枝徹、康東天
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-23790371
[Presentation] Trans-Golgi network膜タンパク質TGN46の細胞内輸送および局在化の分子制御機構2011
- Author(s)
  藤本景子、吉永奈央、平井祥一、廣田有子、静川直子、藤田英明、田中嘉孝
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21590065
[Presentation] Phosphorylation of Ser114 on Atg32 mediates mitophagy2011
- Author(s)
  Aoki, Y., Kanki, T., Hirota, Y., Kurihara, Y., Saigusa, T., and Kang, D.
- Organizer
  European Meeteing on Mitochondrial Pathology
- Place of Presentation
  Spain
- Year and Date
  2011-06-20
- Data Source
  KAKENHI-PROJECT-23790371
[Presentation] 出芽酵母に置けるマイトファジーの生理的役割2011
- Author(s)
  栗原悠介、神吉智丈、廣田有子、青木義政、三枝徹、内海健、康東天
- Organizer
  第44回酵母遺伝学フォーラム
- Place of Presentation
  福岡
- Year and Date
  2011-09-05
- Data Source
  KAKENHI-PROJECT-23790371
[Presentation] 薬物誘発性リン脂質症の分子機構に関する研究2010
- Author(s)
  廣田有子
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Year and Date
  2010-12-12
- Data Source
  KAKENHI-PROJECT-21590065
[Presentation] 薬物誘発性リン脂質症の分子機構に関する研究2010
- Author(s)
  廣田有子、藤本景子、栗原俊祐、阿佐絵里佳、池田一彦、佐野孝一、神吉将之、関二郎、藤田英明、田中嘉孝
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Year and Date
  2010-12-12
- Data Source
  KAKENHI-PROJECT-21590065
[Presentation] Trans-Golgi network膜タンパク質TGN46の細胞内輸送および局在化の分子制御機構に関する研究2010
- Author(s)
  藤本景子、吉永奈央、平井祥一、廣田有子、静川直子、藤田英明、田中嘉孝
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21590065
[Presentation] A small GTPase, human Rab32, is required for the formation of autophagic vacuoles under basal conditions2009
- Author(s)
  Yuko Hirota, Yoshitaka Tanaka
- Organizer
  The 5th International Symposium on Autophagy
- Place of Presentation
  大津
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-21590065

1. Ishii Yuji (90253468)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. TANAKA Yoshitaka (20217095)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. FUJIMOTO Keiko (00634198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 宮内優 (50799947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 神吉智丈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 康東天

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 内海健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirota Yuko 廣田 有子

HIROTA Yuko 廣田 有子

Research Projects

Research Products

Co-Researchers

内外環境の破綻による次世代影響評価：発達障害と性未成熟の機構の検証と予防

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of multidrug resistance acquisition by lysosomal membrane protein LAPTM4bPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Assessment of the impact of the disturbance in endo-and-xeno environment on the next-generation: study on the mechanism for sexual immaturity and developmental disorders and the preventive method

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Lysosomal membrane protein LAPTM4a functions in multiple drug resistance.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive identification and function analysis of new autophagy-related genes using fly cultured cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of molecular mechanism of autophagy by GTP-binding protein Rab32

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Autophagy-A Double-Edged Sword-Cell Survival or Death- Rab GTPases in Autophagy2013

Author(s)

Total Pages

Publisher

Data Source

[Book] Autophagy2013

Author(s)

Publisher

Data Source

[Book] Autophagy - A Double-Edged Sword - Cell Survival or Death? "Rab GTPases in Autophagy"2013

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A42022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LAPTM4α is targeted from the Golgi to late endosomes/lysosomes in a manner dependent on the E3 ubiquitin ligase Nedd4-1 and ESCRT proteins2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HM1.24/BST-2 is constitutively poly-ubiquitinated at the N-terminal amino acid in the cytoplasmic domain2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lysosomal integral membrane protein LGP85 (LIMP-2) is ubiquitinated at the N-terminal cytoplasmic domain2020

Author(s)

Journal Title

DOI

Data Source

Hirota Yuko 廣田有子

HIROTA Yuko 廣田有子