okamoto masanori 岡本正則

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OKAMOTO Masanori 岡本正則

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Researcher Number	50596781
Other IDs	https://orcid.org/0000-0003-0351-865X
Affiliation (Current)	2025: 信州大学, 学術研究院医学系, 准教授
Affiliation (based on the past Project Information) *help	2025: 信州大学, 学術研究院医学系, 准教授 2022 – 2023: 信州大学, 医学部附属病院, 講師 2018 – 2021: 信州大学, 医学部附属病院, 助教(特定雇用) 2017: 信州大学, 医学部附属病院, 診療助教 2016: 信州大学, 医学部附属病院, 医員 2014 – 2016: 信州大学, 医学部附属病院, 助教(診療)
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator Orthopaedic surgery / Nanomaterials/Nanobioscience
Keywords	Principal Investigator 骨肉腫 / スクレロスチン / 新規治療薬 / Wnt / Wnt経路 / 抗がん剤 / 悪性骨腫瘍 / 骨代謝 / Lｒｐ5/6 / 骨芽細胞 … More / 骨形成 / 骨芽細胞分化 / Lrp5/6 / Wnt5a / Wntシグナル … More Except Principal Investigator 生体安全性 / scaffold / 四肢機能再建学 / エンテーシス / 骨再生 / 骨移植 / 骨折 / カーボンナノチューブ / ナノ粒子チューブ / ナノ粒子ナノチューブ / ナノ材料 / 生体材料 / 生体界面 / DDS / Scafford / ナノチューブ / ナノ粒子 / ナノ機能材料 / 骨髄細胞 / ナノカーボンファイバー / 足場材 / 再生医療 / カーボンファイバー / 骨組織再生 Less

悪性骨軟部腫瘍に対する新規治療薬の開発ーPDXモデルマウスでの抗腫瘍効果の検証ーPrincipal Investigator
- Principal Investigator
  
  岡本正則
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Shinshu University
Development of a Novel Osteosarcoma Treatment: Mechanism of Action, Target Sites, and Synergistic Effects with Chemotherapeutic Agents of SclerostinPrincipal Investigator
- Principal Investigator
  
  Okamoto Masanori
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Shinshu University
ANTITUMOR EFFECT OF SCLEROSTIN AGAINST MALIGNANT BONE TUMORPrincipal Investigator
- Principal Investigator
  
  Okamoto Masanori
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Shinshu University
Titanium fiber paper for compound fracture repair, bone tissue regeneration and enthesis reattachment.
- Principal Investigator
  
  Saito Naoto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
The role of Wnt5a in osteoblast and osteosarcomaPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Masanori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
Development of a biofunctional scaffold using nanocarbon fiber sheets for bone regenaration
- Principal Investigator
  
  SAITO Naoto
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
Establishment and safety evaluation of carbon nanotube (CNT) bio-interface technology for developing high-function biomaterials using CNTs
- Principal Investigator
  
  SAITO Naoto
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Nanomaterials/Nanobioscience
- Research Institution
  Shinshu University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Antitumor Effect of Sclerostin against Osteosarcoma2021
- Author(s)
  Ideta Hirokazu、Yoshida Kazushige、Okamoto Masanori、Sasaki Jun、Kito Munehisa、Aoki Kaoru、Yoshimura Yasuo、Suzuki Shuichiro、Tanaka Atsushi、Takazawa Akira、Haniu Hisao、Uemura Takeshi、Takizawa Takashi、Sobajima Atsushi、Kamanaka Takayuki、Takahashi Jun、Kato Hiroyuki、Saito Naoto
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 23 Pages: 6015-6015
- DOI
  10.3390/cancers13236015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01584, KAKENHI-PROJECT-21K09319
[Journal Article] A Review of T-Cell Related Therapy for Osteosarcoma2020
- Author(s)
  Yoshida Kazushige、Okamoto Masanori、Aoki Kaoru、Takahashi Jun、Saito Naoto
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 14 Pages: 4877-4877
- DOI
  10.3390/ijms21144877
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16651
[Journal Article] A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler.2017
- Author(s)
  Tanaka M, Sato Y, Haniu H, Nomura H, Kobayashi S, Takanashi S, Okamoto M, Takizawa T, Aoki K, Usui Y, Oishi A, Kato H, Saito N.
- Journal Title
  
  PLoｓ One
  
  Volume: 12 Issue: 2 Pages: e0172601-e0172601
- DOI
  10.1371/journal.pone.0172601
- NAID
  120007100159
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24241045, KAKENHI-PROJECT-15H04131
[Journal Article] Physico-chemical, in vitro, and in vivo evaluation of a 3d unidirectional porous hydroxyapatite scaffold for bone regeneration.2017
- Author(s)
  Tanaka M, Haniu H, Kamanaka T, Takizawa T, Sobajima A, Yoshida K, Aoki K, Okamoto M, Kato H, Saito N.
- Journal Title
  
  Materials
  
  Volume: 10 Issue: 1 Pages: 33-33
- DOI
  10.3390/ma10010033
- NAID
  120007113511
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24241045
[Journal Article] Titanium fiber plates for bone tissue repair.2017
- Author(s)
  Takizawa T, Nakayama N, Haniu H, Aoki K, Okamoto M, Nomura H, Tanaka M, Sobajima　A, Yoshida K, Kamanaka T, Ajima K, Oishi A, Kuroda C, Ishida H, Okano S, Kobayashi S, Kato H, and Saito N.
- Journal Title
  
  Advanced Materials.
  
  Volume: 30 Issue: 4 Pages: 1-11
- DOI
  10.1002/adma.201703608
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21065, KAKENHI-PROJECT-15K15547
[Journal Article] In vitro and in vivo evaluation of a three-dimensional porous multi-walled carbon nanotube scaffold for bone regeneration.2017
- Author(s)
  Tanaka M, Sato Y, Zhang M, Haniu H, Okamoto M, Aoki K, Takizawa T, Yoshida K, Sobajima A, Kamanaka T, Kato H, Saito N.
- Journal Title
  
  Nanomaterials-Baseｌ
  
  Volume: 7 Issue: 2 Pages: 46-46
- DOI
  10.3390/nano7020046
- NAID
  120007113512
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24241045, KAKENHI-PROJECT-15H04131
[Journal Article] An advanced in-situ imaging method using heavy metal doped hollow tubes to evaluate the biokinetics of carbon nanotubes in vivo2015
- Author(s)
  Kobayashi S, Tsuruoka S, Usui Y, Haniu H, Aoki K, Takanashi S, Okamoto M, Nomura H, Tanaka M, Aiso S, Saito M, Kato H, Saito N
- Journal Title
  
  NPG Asia Mater
  
  Volume: 7 Issue: 7 Pages: 203-203
- DOI
  10.1038/am.2015.77
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24241045
[Journal Article] Specific biological responses of the synovial membrane to carbon nanotubes2015
- Author(s)
  Nomura H, Takanashi S, Tanaka M, Haniu H, Aoki K, Okamoto M, Kobayashi S, Takizawa T, Usui Y, Oishi A, Kato H, Saito N
- Journal Title
  
  Sci Rep-UK
  
  Volume: 5 Issue: 1 Pages: 14314-14314
- DOI
  10.1038/srep14314
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24241045, KAKENHI-PROJECT-26861179
[Journal Article] Endocytosis of multiwalled carbon nanotubes in bronchial epithelial and mesothelial cells2015
- Author(s)
  Maruyama K, Haniu H, Saito N, Matsuda Y, Tsukahara T, Kobayashi S, Tanaka M, Aoki K, Takanashi S, Okamoto M, Kato H
- Journal Title
  
  Biomed Res Int
  
  Volume: 2015 Pages: 793186-793186
- DOI
  10.1155/2015/793186
- NAID
  120007110651
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24241045
[Journal Article] Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells2014
- Author(s)
  Haniu H, Saito N, Matsuda N, Tsukahara T, Usui Y, Maruyama K, Takanashi S, Aoki K, Kobayashi S, Nomura H, Tanaka M, Okamoto M, Kato H
- Journal Title
  
  Int J Nanomed
  
  Volume: ９ Pages: 1979-1989
- DOI
  10.2147/ijn.s58661
- NAID
  120007110603
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24241045, KAKENHI-PROJECT-24659670
[Journal Article] Safe clinical use of carbon nanotubes as innovative biomaterials2014
- Author(s)
  Saito N, Haniu H, Usui Y, Aoki K, Hara K, Takanashi S, Shimizu M, Narita N, Okamoto M, Kobayashi S, Nomura H, Kato H, Nishimura N, Taruta S, Endo M
- Journal Title
  
  Chem Rev
  
  Volume: 114 Issue: 11 Pages: 6040-6079
- DOI
  10.1021/cr400341h
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24240076, KAKENHI-PROJECT-24241045, KAKENHI-PROJECT-24659670
[Journal Article] Noncanonical Wnt5a enhances Wnt/-catenin signaling during osteogenesis.2014
- Author(s)
  Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., Kobayashi, Y.
- Journal Title
  
  Sci. report
  
  Volume: 4 Issue: 1 Pages: 4493-4493
- DOI
  10.1038/srep04493
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23112007, KAKENHI-PROJECT-23593054, KAKENHI-PROJECT-23791668, KAKENHI-PROJECT-24240076, KAKENHI-PROJECT-24241045, KAKENHI-PROJECT-24390080, KAKENHI-PROJECT-24390417, KAKENHI-PROJECT-24592821, KAKENHI-PROJECT-24659833, KAKENHI-PROJECT-25221310, KAKENHI-PROJECT-25293423, KAKENHI-PROJECT-25462385, KAKENHI-PROJECT-25462904, KAKENHI-PROJECT-25462905, KAKENHI-PROJECT-25670792, KAKENHI-PROJECT-25670793, KAKENHI-PROJECT-26462825, KAKENHI-PROJECT-26670814
[Journal Article] Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response2013
- Author(s)
  Haniu H, Saito N, Matsuda Y, Tsukahara T, Maruyama K, Usui Y, Aoki K, Takanashi S, Kobayashi S, Nomura H, Okamoto M, Shimizu M, Kato H
- Journal Title
  
  Toxicol in Vitro
  
  Volume: 27 Issue: 6 Pages: 1679-1685
- DOI
  10.1016/j.tiv.2013.04.012
- NAID
  120007110519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24240076, KAKENHI-PROJECT-24241045, KAKENHI-PROJECT-24659670, KAKENHI-PROJECT-25350524, KAKENHI-PROJECT-25462365
[Journal Article] Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice2012
- Author(s)
  Takanashi S, Hara K, Aoki K, Usui Y, Shimizu M, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Okamoto M, Kobayashi S, Kato H, Sano K, Nishimura N, Tsutsumi H, Machida K Saito N
- Journal Title
  
  Sci Rep
  
  Volume: 2 Issue: 1 Pages: 498-498
- DOI
  10.1038/srep00498
- NAID
  120007110636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] 骨肉腫に対するスクレロスチンの抗腫瘍効果2022
- Author(s)
  出田宏和, 吉田和薫, 岡本正則, 青木薫, 鬼頭宗久, 田中厚誌, 小松幸子, 高橋淳, 齋藤直人
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-21K09319
[Presentation] THERAPEUTIC EFFECT OF SCLEROSTIN ON OSTEOSARCOMA2019
- Author(s)
  Masanori Okamoto, Kazushige Yoshida, Jun Sasaki, Kaoru Aoki, Munehisa Kito, Yasuo Yoshimura, Shuichiro Suzuki, Atsushi Tanaka, Akira Takazawa, Hisao Haniu, Takashi Takizawa, Atsushi Sobajima, Takayuki Kamanaka, Naoto Saito, Hiroyuki Kato
- Organizer
  RCOST 2019(The 41st Annual Meeting of the Royal College of Orthopaedic Surgeons of Thailand)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16651
[Presentation] Antitumor effect of sclerostin against osteosarcoma2018
- Author(s)
  Masanori Okamoto
- Organizer
  EMSOS 2018 (31st Annual Meeting of The European Musculo-Skeletal Oncology Society)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16651
[Presentation] Antitumor effect of sclerostin against osteosarcoma2018
- Author(s)
  Masanori Okamoto
- Organizer
  APMSTS 2018 (12th Asia Pacific Musculo Skeletal Tumor Society meeting)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16651
[Presentation] THERAPEUTIC EFFECT OF SCLEROSTIN ON OSTEOSARCOMA2018
- Author(s)
  Masanori Okamoto
- Organizer
  CTOS 2018 (2018 Connective Tissue Oncology Society Annual Meeting)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16651
[Presentation] 骨肉腫に対する古典的Wntシグナル阻害因子スクレロスチンの抗腫瘍効果2018
- Author(s)
  岡本正則
- Organizer
  第51回日本整形外科学会骨・軟部腫瘍学術集会
- Data Source
  KAKENHI-PROJECT-18K16651
[Presentation] 骨組織修復のためのチタンファイバープレート2017
- Author(s)
  滝沢崇、青木薫、岡本正則、田中学、傍島淳、吉田和薫、鎌仲貴之、加藤博之、羽二生久夫、安嶋久美子、大石歩、黒田千佳、石田悠、齋藤直人、中山昇
- Organizer
  第119回信州整形外科懇談会
- Data Source
  KAKENHI-PROJECT-15K15547
[Presentation] 骨組織修復のためのチタンファイバープレート2017
- Author(s)
  滝沢崇、中山昇、羽二生久夫、青木薫、岡本正則、田中学、傍島淳、吉田和薫、鎌仲貴之、安嶋久美子、加藤博之、齋藤直人
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-15K15547
[Presentation] 配向連通多孔体ハイドロキシアパタイト担体のin vitroおよびin vivoにおける骨再生能評価.2016
- Author(s)
  田中学, 齋藤直人, 羽二生久夫, 野村博紀, 小林伸輔, 岡本正則, 青木薫, 滝沢崇, 傍島淳, 吉田和薫, 加藤博之.
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場、福岡
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] 多層カーボンナノチューブのラット膝関節内注射による他臓器への移行の検討.2016
- Author(s)
  傍島淳, 齋藤直人, 羽二生久夫, 青木薫, 岡本正則, 田中学, 滝沢崇, 吉田和薫, 大石歩, 安嶋久美子, 黒田千佳, 加藤博之.
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場、福岡
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Noncanonical WNT5A regulates the expression of LRP5/6 in osteosarcoma2016
- Author(s)
  Masanori Okamoto, Kazushige Yoshida, Kaoru Aoki, Munehisa Kito, Atsushi Tanaka, Shuichiro Suzuki, Akira Takazawa, Yasuo Yoshimura, Hiroyuki Kato, Naoto Saito
- Organizer
  Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Therapeutics
- Place of Presentation
  Maui, Hawaii, USA
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861181
[Presentation] チタンペーパーの骨再生における足場材としての有用性の検討（その2）2016
- Author(s)
  滝沢崇, 齋藤直人, 中山昇, 羽二生久夫, 青木薫, 岡本正則, 田中学, 傍島淳, 吉田和薫, 大石歩, 安嶋久美子
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場、福岡
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K15547
[Presentation] 多層カーボンナノチューブの異なる分散条件による細胞応答性.2016
- Author(s)
  黒田千佳, 羽二生久夫, 傍島淳, 野村博紀, 生田太郎, 青木薫, 安嶋久美子, 岡本正則,田中学, 滝沢崇, 吉田和薫, 齋藤直人.
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  ウインクあいち、名古屋
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Antitumor effects for osteosarcoma by multi-walled carbon nanotubes2016
- Author(s)
  Aoki K, Okamoto M, Tanaka M, Takizawa T, Yoshida K, Sobajima A, Kato H, Haniu H, Saito N
- Organizer
  10th AACR-JCA Joint Conference
- Place of Presentation
  Maui, USA
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] 非古典経路のWNT5Aは骨肉腫においてLRP5/6の発現を調節する2016
- Author(s)
  岡本正則，吉田和薫，青木　薫，鬼頭宗久，田中厚誌，鈴木周一郎，髙沢　彰，福澤拓馬，薄井雄企，羽二生久夫，小林伸輔，田中学，吉村康夫，小林泰浩，加藤博之，齋藤直人
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26861181
[Presentation] 多孔質に成型した多層カーボンナノチューブブロック体の骨形成への影響2016
- Author(s)
  田中学, 齋藤直人, Mei Zhang, 佐藤義倫, 羽二生久夫, 滝沢崇, 野村博紀, 小林伸輔, 岡本正則, 高梨誠司, 青木薫, 薄井雄企, 加藤博之
- Organizer
  第117回信州整形外科懇談会
- Place of Presentation
  信州大学、長野県松本市
- Year and Date
  2016-02-20
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Peapod様カーボンナノチューブのバイオレスポンス評価.2016
- Author(s)
  羽二生久夫, 小林伸輔, 鶴岡秀志, 丸山佳与, 松田佳和, 青木薫, 岡本正則, 田中学, 滝沢崇, 傍島淳, 吉田和薫, 薄井雄企, 加藤博之, 齋藤直人.
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  ウインクあいち、名古屋
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Anti-tumor effects for osteosarcoma by carbon nanotubes.2016
- Author(s)
  Aoki K, Okamoto M, Tanaka M, Takizawa T, Yoshida K, Sobajima A, Kato H, Haniu H, Saito N.
- Organizer
  10th World Biomaterials Congress
- Place of Presentation
  Montreal, Canada
- Year and Date
  2016-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] A capacity of porous carbon nanotube blocks as scaffold of bone regeneration2015
- Author(s)
  Tanaka M, Saito N, Zhang M, Sato Y, Haniu H, Takizawa T, Nomura H, Kobayashi S, Okamoto M, Takanashi S, Aoki K, Usui Y, Kato H
- Organizer
  12th Bone Biology Forum
- Place of Presentation
  Cross Wave Makuhari, Chiba, Chiba, Japan
- Year and Date
  2015-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] The effect of carbon nanotube blocks on bone regeneration2015
- Author(s)
  Tanaka M, Saito N, Zhang M, Sato Y, Haniu H, Takizawa T, Nomura H, Kobayashi S, Okamoto M, Takanashi S, Aoki K, Usui Y, Kato H
- Organizer
  6th Symposium on Carbon Nanomaterials Biology, Medicine & Toxicology
- Place of Presentation
  Nagoya University, Nagoya, Aichi, Japan
- Year and Date
  2015-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] チタンペーパーの骨再生における足場材としての有用性の検討2015
- Author(s)
  滝沢崇, 田中学, 齋藤直人, 羽二生久夫, 中山昇, 青木薫, 岡本正則, 高梨誠司, 小林伸輔, 野村博紀, 加藤博之
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-15K15547
[Presentation] 脳関連細胞種での多層カーボンナノチューブによる生物学的応答2015
- Author(s)
  羽二生久夫, 齋藤直人, 丸山佳与, 松田佳和, 青木薫, 高梨誠司, 岡本正則, 小林伸輔, 野村博紀, 田中学, 滝沢崇, 大石歩, 薄井雄企, 加藤博之
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂他、石川県金沢市
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] in vitroでのPeapod-CNTのバイオレスポンス2015
- Author(s)
  丸山佳与, 羽二生久夫, 小林伸輔, 鶴岡秀志, 松田佳和, 青木薫, 岡本正則, 高梨誠司, 野村博紀, 田中学, 滝沢崇, 大石歩, 薄井雄企, 齋藤直人
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂他、石川県金沢市
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Porous multi-walled carbon nanotube block (p-MWCNT block)の骨形成への影響2015
- Author(s)
  田中学, 齋藤直人, Zhang Mei, 佐藤義倫, 滝沢崇, 野村博紀, 小林伸輔, 岡本正則, 青木薫, 薄井雄企, 羽二生久夫, 加藤博之
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山国際会議場、富山県富山市
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] 骨肉腫モデルマウスに対するカーボンナノチューブの効果2015
- Author(s)
  青木薫, 高梨誠司, 岡本正則, 小林伸輔, 野村博紀, 田中学, 滝沢崇, 大石歩, 加藤博之, 薄井雄企, 羽二生久夫, 齋藤直人
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山国際会議場、富山県富山市
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Evaluation of multi-walled carbon nanotubes using the MC3T3-E1 cell line2015
- Author(s)
  Haniu H, Saito N, Maruyama K, Matsuda N, Tanaka M, Aoki K, Okamoto M, Kobayashi S, Nomura H, Takizawa T, Ohishi A, Usui Y, Kato H
- Organizer
  TechConnect World Innovation Conference & Expo-2015
- Place of Presentation
  Washinton DC, USA
- Year and Date
  2015-06-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Antitumor effects for osteosarcoma cells by carbon nanotubes2015
- Author(s)
  Aoki K, Okamoto M, Takanashi S, Kobayashi S, Nomura H, Tanaka M, Takizawa T, Kato H, Usui Y, Haniu H, Saito N
- Organizer
  27th European Conference on Biomaterials
- Place of Presentation
  Krakow, Poland
- Year and Date
  2015-08-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Drug delivery system by carbon nanotubes for sarcoma cells.2013
- Author(s)
  Aoki K, Haniu H, Shimizu M, Takanashi S, Okamoto M, Kobayashi S, Nomura H, Usui Y, Kato H, Saito N.
- Organizer
  6th International Symposium on Nanotechnology, Occupational and Environmental Health.
- Place of Presentation
  Nagoya, Japan.
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Endocytosis of MWCNT in BEAS-2B cells are affected by the culture medium type.2013
- Author(s)
  Haniu H, Saito N, Matsuda N, Maruyama K, Tsukahara T, Usui Y, Takanashi S, Aoki K, Kobayashi S, Nomura H, Okamoto M, Shimizu M, Kato H.
- Organizer
  The 6th International Symposium on Nanotechnology, Occupational and Environmental Health.
- Place of Presentation
  Nagoya, Japan.
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Endocytosis of MWCNT in BEAS-2B cells are affected by the culture medium type.2013
- Author(s)
  Haniu H, Saito N, Matsuda N, Maruyama K, Tsukahara T, Usui Y, Takanashi S, Aoki K, Kobayashi S, Nomura H, Okamoto M, Shimizu M, Kato H.
- Organizer
  6th International Symposium on Nanotechnology, Occupational and Environmental Health.
- Place of Presentation
  Nagoya, Japan.
- Data Source
  KAKENHI-PROJECT-24659670
[Presentation] Wnt5a enhances Wnt/ß-catenin signaling through the up-regulation of Lrp5/6 during osteogenesis.(President’s Poster Competition Award)2013
- Author(s)
  Okamoto M, Udagawa N, Yamashita T, Uehara S, Kato H, Saito N, Minami Y, Takahashi N, Kobayashi Y.
- Organizer
  ASBMR 2013 Annual Meeting.
- Place of Presentation
  Baltimore, Maryland, USA.
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Carcinogenicity evaluation of carbon nanotubes in rasH2 mice.2013
- Author(s)
  Takanashi S, Haniu H, Usui U, Aoki K, Okamoto M, Kobayashi S, Nomura H, Tanaka M, Kato H, Saito N.
- Organizer
  The 6th International Symposium on Nanotechnology, Occupational and Environmental Health.
- Place of Presentation
  Nagoya, Japan.
- Data Source
  KAKENHI-PROJECT-24659670
[Presentation] Intraarticular reaction and secretion of inflammatory chemokines to Multi wall carbon nanotubes.2013
- Author(s)
  Nomura H, Haniu H, Takanashi S, Kobayashi S, Okamoto M, Aoki K, Maruyama K, Usui Y, Kato H, Saito N.
- Organizer
  8th Combined Meeting of Orthopaedic Research Societies
- Place of Presentation
  Venice, Italy.
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] An innovative method to evaluate biodistribution and kinetics of carbon nanotubes using CNT peapods.2013
- Author(s)
  Kobayashi S, Tsuruoka S, Usui Y, Haniu H, Aoki K, Shimizu M, Takanashi S, Okamoto M, Kato H, Saito N.
- Organizer
  6th International Symposium on Nanotechnology, Occupational and Environmental Health.
- Place of Presentation
  Nagoya, Japan.
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Intraarticular reaction and secretion of inflammatory chemokines to Multi wall carbon nanotubes.2013
- Author(s)
  Nomura H, Haniu H, Takanashi S, Kobayashi S, Okamoto M, Aoki K, Maruyama K, Usui Y, Kato H, Saito N.
- Organizer
  6th International Symposium on Nanotechnology, Occupational and Environmental Health.
- Place of Presentation
  Nagoya, Japan.
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Carcinogenicity evaluation of carbon nanotubes in rasH2 mice.2013
- Author(s)
  Takanashi S, Haniu H, Usui U, Aoki K, Okamoto M, Kobayashi S, Nomura H, Tanaka M, Kato H, Saito N.
- Organizer
  The 6th International Symposium on Nanotechnology, Occupational and Environmental Health.
- Place of Presentation
  Nagoya, Japan.
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] カーボンナノチューブは骨芽細胞との双方向性の相互作用により骨の石灰化を促進する2012
- Author(s)
  清水政幸, 青木薫, 成田伸代, 原一生, 羽二生久夫, 岡本正則, 高梨誠司, 加藤博之, 小林泰浩, 中村浩彰, 川原一郎, 宇田川信之, 高橋直之, 小澤英浩, 薄井雄企, 齋藤直人
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Peapod-CNTによるカーボンナノチューブの体内動態評価方法の開発2012
- Author(s)
  小林伸輔, 高梨誠司, 羽二生久夫, 岡本正則, 清水政幸, 荻原伸英, 石垣範雄, 中村恒一, 　加藤博之, 薄井雄企, 齋藤直人
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] カーボンナノチューブに対する細胞反応の定量的評価法の開発: ONE TO ONE法2012
- Author(s)
  高梨誠司, 羽二生久夫, 石垣範雄, 荻原伸英, 青木薫, 清水政幸, 岡本正則, 小林伸輔, 野村博紀, 加藤博之, 薄井雄企, 齋藤直人
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Effects for osteosarcoma cells by carbon nanotubes.
- Author(s)
  Aoki K, Okamoto M, Kobayashi S, Nomura H, Tanaka M, Kato H, Usui U, Haniu H, Saito N.
- Organizer
  ANZBMS Annual Scientific Meeting
- Place of Presentation
  Queenstown, New Zealand
- Year and Date
  2014-09-07 – 2014-09-10
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] カーボンナノチューブに対する細胞反応の定量的評価法の開発: ONE TO ONE法
- Author(s)
  高梨誠司, 羽二生久夫, 石垣範雄,青木薫, 清水政幸, 岡本正則, 小林伸輔, 野村博紀, 加藤博之, 薄井雄企, 齋藤直人
- Organizer
  第111回信州整形外科懇談会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Comparison of intraarticular reactions to Multi Walled Carbon Nanotubes (MWCNTs) by injection at once with three divided times.
- Author(s)
  Nomura H, Haniu H, Takanashi S, Kobayashi S, Okamoto M, Aoki K, Maruyama K, Usui Y, Kato H, Saito N.
- Organizer
  22th Annual Meeting of the European Orthopaedic Research Society
- Place of Presentation
  Nantes, France
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Noncanonical Wnt5a enhances Wnt/b-catenin signaling through the up-regulation of Lrp5/6 during osteoblastogenesis
- Author(s)
  Masanori Okamoto, Nobuyuki Udagawa, Teruhito Yamashita, Shunsuke Uehara, Kaoru Aoki, Hisao Haniu, Hiroyuki Kato, Naoto Saito, Naoyuki Takahashi, Yasuhiro Kobayashi
- Organizer
  ANZBMS Annual Scientific Meeting
- Place of Presentation
  MILLENNIUM HOTEL, QUEENSTOWN 9300, NEW ZEALAND
- Year and Date
  2014-09-07 – 2014-09-10
- Data Source
  KAKENHI-PROJECT-26861181
[Presentation] カーボンナノチューブをモデルにした個の安全性評価の検討
- Author(s)
  羽二生久夫, 齋藤直人, 松田佳和, 石川えり, 薄井雄企, 青木薫, 高梨誠司, 小林伸輔, 岡本正則, 加藤博之
- Organizer
  第2回日本レギュラトリーサイエンス学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] カーボンナノチューブの細胞毒性：形とタイプの影響
- Author(s)
  羽二生久夫, 齋藤直人, 松田佳和, 薄井雄企, 高梨誠司, 小林伸輔, 岡本正則, 清水政幸, 荻原伸英, 石垣範雄, 中村恒一, 加藤博之
- Organizer
  第39回日本毒性学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] カーボンナノチューブ複合ポリエチレンを人工関節の摺動部に用いるための生体安全性評価
- Author(s)
  齋藤直人, 西村直之, 薄井雄企, 羽二生久夫, 青木薫, 岡本正則, 高梨誠司, 小林伸輔, 野村博紀, 加藤博之
- Organizer
  第5回医療機器に関するレギュラトリーサイエンス研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] プロテオミクスを使ったカーボンナノチューブの物性評価
- Author(s)
  羽二生久夫, 齋藤直人, 松田佳和, 石川えり, 薄井雄企, 青木薫, 高梨誠司, 小林伸輔, 岡本正則, 加藤博之
- Organizer
  日本プロテオーム学会2012年大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Wnt5a up-regulated the expression of Lrp5/6 during osteoblastogenesis.
- Author(s)
  Okamoto M, Udagawa N, Yamashita T, Uehara S, Kato H, Saito N, Takahashi N, Kobayashi Y.
- Organizer
  5th International Conference on Osteoimmunology
- Place of Presentation
  Kos, Greece
- Year and Date
  2014-06-15 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Noncanonical Wnt5a enhances Wnt/b-catenin signaling through the up-regulation of Lrp5/6 during osteoblastogenesis.
- Author(s)
  Okamoto M, Udagawa N, Yamashita T, Uehara S, Aoki K, Haniu H, Kato H, Saito N, Takahashi N, Kobayashi Y.
- Organizer
  ANZBMS Annual Scientific Meeting
- Place of Presentation
  Queenstown, New Zealand
- Year and Date
  2014-09-07 – 2014-09-10
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Study of the manufacturing process of multi-walled carbon nanotubes for improving biocompatibility
- Author(s)
  Haniu H, Saito N, Matsuda Y, Usui Y, Takanashi S, Kobayashi S, Okamoto M, Shimizu M, Ogihara N, Ishigaki N, Nakamura K, Kato H.
- Organizer
  The 6th International Congress of Asian Society of Toxicology
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-24241045

1. SAITO Naoto (80283258)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. KATO Hiroyuki (40204490)

# of Collaborated Projects: 3 results

# of Collaborated Products: 46 results
3. HANIU Hisao (30252050)

# of Collaborated Projects: 3 results

# of Collaborated Products: 47 results
4. TAKANASHI Seiji (70596783)

# of Collaborated Projects: 3 results

# of Collaborated Products: 32 results
5. KOBAYASHI Shinsuke (40624705)

# of Collaborated Projects: 3 results

# of Collaborated Products: 40 results
6. TANAKA Manabu (30723069)

# of Collaborated Projects: 3 results

# of Collaborated Products: 29 results
7. KIM Yoong Ahm (70362100)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. USUI Yuki (00467169)

# of Collaborated Projects: 2 results

# of Collaborated Products: 34 results
9. SHIMIZU Masayuki (40467171)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
10. AOKI Kaoru (30467170)

# of Collaborated Projects: 2 results

# of Collaborated Products: 42 results
11. NOMURA Hiroki (40646543)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
12. AJIMA Kumiko (70584051)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
13. TAKIZAWA Takashi (40748109)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
14. SOBAJIMA Atsushi (00770760)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
15. KAMANAKA Takayuki (30791884)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
16. ENDO Morinobu (10021015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. ISHIGAKI Norio (20447725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
18. HARA Kazuo (00532045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
19. YOSHIDA Kazushige (60770774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
20. 佐々木克典 (30170666)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 樽田誠一 (00217209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 宇田川信之 (70245801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
23. 中山昇 (80336445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
24. 出田宏和 (00838534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. KURODA Chika

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
26. OKANO Satomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. ISHIDA Haruka

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
28. 斎藤直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 52 results
29. 南康博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

okamoto masanori 岡本 正則

OKAMOTO Masanori 岡本 正則

Research Projects

Research Products

Co-Researchers

悪性骨軟部腫瘍に対する新規治療薬の開発ーPDXモデルマウスでの抗腫瘍効果の検証ーPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a Novel Osteosarcoma Treatment: Mechanism of Action, Target Sites, and Synergistic Effects with Chemotherapeutic Agents of SclerostinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ANTITUMOR EFFECT OF SCLEROSTIN AGAINST MALIGNANT BONE TUMORPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Titanium fiber paper for compound fracture repair, bone tissue regeneration and enthesis reattachment.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of Wnt5a in osteoblast and osteosarcomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a biofunctional scaffold using nanocarbon fiber sheets for bone regenaration

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment and safety evaluation of carbon nanotube (CNT) bio-interface technology for developing high-function biomaterials using CNTs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Antitumor Effect of Sclerostin against Osteosarcoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Review of T-Cell Related Therapy for Osteosarcoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Physico-chemical, in vitro, and in vivo evaluation of a 3d unidirectional porous hydroxyapatite scaffold for bone regeneration.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Titanium fiber plates for bone tissue repair.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vitro and in vivo evaluation of a three-dimensional porous multi-walled carbon nanotube scaffold for bone regeneration.2017

Author(s)

Journal Title

DOI

NAID

Data Source

okamoto masanori 岡本正則

OKAMOTO Masanori 岡本正則

[Journal Article] Noncanonical Wnt5a enhances Wnt/-catenin signaling during osteogenesis.2014