Yamane Hiromichi 山根弘路

… Alternative Names

YAMANE Hiromichi 山根弘路

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Researcher Number	50624897
Other IDs
Affiliation (Current)	2025: 川崎医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 川崎医科大学, 医学部, 准教授 2014: 川崎医科大学, 医学部, 准教授 2012 – 2013: 川崎医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine
Keywords	Principal Investigator 治療シークエンス / 新規抗がん剤 / IC50値 / 耐性株 / アポトーシス / Eribulin / Trabectedin / Doxorubicin / 軟部肉腫 / 炎症性サイトカイン … More / 血清CRP値 / ヘプシジン / がん性悪液質 / 固形腫瘍 / 肺癌 / 予後予測因子 / Paps / 予後相関 / 赤血球沈降速度 / フェリチン / CRP / 鉄代謝 / 炎症性マーカー / 終末期患者予後 / 鉄代謝機構 / 予後予測モデル / フェロポルチン / 血清フェリチン値 … More Except Principal Investigator 薬剤耐性 / EGFR / ALK / 肺癌 / プロテオーム / JAK2 / トランスクリプトーム / メタボローム / 代謝 / チロシンキナーゼ阻害剤 / APOBEC / APOBEC3B / チロシンキナーゼ阻害 / プロテオーム解析 / 血管新生 / 遺伝子改変マウス / STAT3 / mTOR Less

Analysis of drug-resistant cells induced by molecular target agents and prevention of the resistance
- Principal Investigator
  
  瀧川奈義夫
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kawasaki Medical School
Basic research for the establishment of adequate sequence of chemotherapy in the treatment of advanced soft tissue sarcomaPrincipal Investigator
- Principal Investigator
  
  山根弘路
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kawasaki Medical School
Overcoming treatment resistance based on metabolic properties of EGFR gene mutations
- Principal Investigator
  
  Takigawa Nagio
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kawasaki Medical School
Study of the cancer cachexia for the establishment of new treatment modality using the analysis of the iron metabolic pathwayPrincipal Investigator
- Principal Investigator
  
  Yamane Hiromichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kawasaki Medical School
Identification and overcoming specific signals in EGFR-TKI resistant lung cancer
- Principal Investigator
  
  Takigawa Nagio
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kawasaki Medical School
Effects of molecular-targeted drugs on nonsmoking-related lung cancer models
- Principal Investigator
  
  TAKIGAWA Nagio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kawasaki Medical School

All 2024 2023 2021 2020 2017 2016

All Journal Article Presentation

[Journal Article] The complexity of EGFR exon 19 deletion and L858R mutant cells as assessed by proteomics, transcriptomics, and metabolomics2023
- Author(s)
  Ochi Nobuaki、Takeyama Masami、Miyake Noriko、Fuchigami Maki、Yamane Hiromichi、Fukazawa Takuya、Nagasaki Yasunari、Kawahara Tatsuyuki、Nakanishi Hidekazu、Takigawa Nagio
- Journal Title
  
  Experimental Cell Research
  
  Volume: 424 Issue: 1 Pages: 113503-113503
- DOI
  10.1016/j.yexcr.2023.113503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08191
[Journal Article] Targeting ROR1 in combination with osimertinib in EGFR mutant lung cancer cells2021
- Author(s)
  Nakagawa N, Miyake N, Ochi N, Yamane H, Takeyama M, Nagasaki Y, Ikeda T, Yokota E, Fukazawa T, Nakanishi H, Harada D, Kiura K, Takigawa N.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 409 Issue: 2 Pages: 112940-112940
- DOI
  10.1016/j.yexcr.2021.112940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08191
[Journal Article] Effects of (−)-epigallocatechin-3-gallate on EGFR- or Fusion Gene-driven Lung Cancer Cells2017
- Author(s)
  Honda Y, Takigawa N, Ichihara E, Ninomiya T, Kubo T, Ochi N, Yasugi M, Murakami T, Yamane H, Tanimoto M, Kiura K.
- Journal Title
  
  Acta Medica Okayama
  
  Volume: 71 Issue: 6 Pages: 505-512
- DOI
  10.18926/AMO/55587
- NAID
  120006370714
- URL
  https://ousar.lib.okayama-u.ac.jp/55587
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09594
[Journal Article] Synergistic effect of pacritinib with erlotinib on JAK2-mediated resistance in epidermal gowth factor receptor mutation-positive non-small cell lung Cancer.2016
- Author(s)
  Ochi N, Isozaki H, Takeyama M, Singer JW, Yamane H, Honda Y, Kiura K, Takigawa N.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 344 Issue: 2 Pages: 194-200
- DOI
  10.1016/j.yexcr.2016.05.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K09594
[Presentation] トラベクテジンによる化学療法が効果的であったFUS/CHOP融合遺伝子陽性粘液型脂肪肉腫患者4症例2024
- Author(s)
  切士博仁、山根弘路、砂田有哉、三村彩香、市山成彦、河原辰由樹　長﨑泰有、小坂陽子、越智宣昭、中西秀和、瀧川奈義夫1)
- Organizer
  第21回日本臨床腫瘍学会学術集会（JSMO2024）
- Data Source
  KAKENHI-PROJECT-22K09436
[Presentation] EGFRエクソン19欠失とエクソン21 L858R遺伝子変異を有する肺癌細胞株のマルチオミクス解析2023
- Author(s)
  越智宣昭, 竹山雅美, 三宅規子, 山根弘路, 深澤拓哉, 長﨑泰有, 河原辰由樹, 中西秀和, 瀧川奈義夫
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08191
[Presentation] A novel molecular target, superoxide dismutase 1, in ALK inhibitor-resistant lung cancer cells, detected through proteomic analysis2023
- Author(s)
  Nagio Takigawa, Noriko Miyake, Nobuaki Ochi, Masami Takeyama, Hideko Isozaki, Eiki Ichihara, Hiromichi Yamane, Takuya Fukazawa, Yasunari Nagasaki, Tatsuyuki Kawahara, Hidekazu Nakanishi, Katsuyuki Kiura
- Organizer
  American College of CHEST Physician 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08191
[Presentation] EGFR遺伝子変異肺癌におけるROR1標的治療の基礎的検討2021
- Author(s)
  三宅規子、越智宣昭、中川　望、竹山雅美、山根弘路、長﨑泰有、岩井美樹、横田悦子、深澤拓也、瀧川奈義夫
- Organizer
  第62回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08191
[Presentation] 進行期がん患者における血清炎症性マーカーおよび血清ヘプシジン25濃度と患者予後との関係性について2020
- Author(s)
  山根弘路　越智宜昭　中西秀和　小原弘之　六原純子　瀧川奈義夫
- Organizer
  第25回　日本緩和医療学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07279
[Presentation] 終末期肺がん患者予後に影響する血清炎症性マーカーの検討と新たな予後予測指標の提案2020
- Author(s)
  山根弘路　越智宜昭　中川望　長崎康有　河原辰由樹　市山成彦　田岡征高　三村彩香　小原弘之　瀧川奈義夫
- Organizer
  第61回　日本肺癌学会　学術集会
- Data Source
  KAKENHI-PROJECT-18K07279
[Presentation] 肺がん患者におけるACPを考える2020
- Author(s)
  山根弘路
- Organizer
  第61回　日本肺癌学会　学術集会　ワークショップ5
- Data Source
  KAKENHI-PROJECT-18K07279
[Presentation] ドライバーオンコジーンを有する肺がんに対するエピガロカテキンガレート（EGCG)の効果2017
- Author(s)
  本多宣裕, 瀧川奈義夫, 越智宣昭, 二宮崇, 八杉昌幸, 久保寿夫, 磯崎英子, 市原英基, 堀田勝幸, 山根弘路, 谷本光音, 木浦勝行
- Organizer
  第57回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-16K09594
[Presentation] PacritinibによるJAK2を介したEGFR-TKI耐性の克服2016
- Author(s)
  越智宣昭、山根弘路、本多宣裕、磯崎英子、木浦勝行、瀧川奈義夫
- Organizer
  第57回日本肺癌学会学術集会
- Place of Presentation
  福岡サンパレス(福岡県福岡市)
- Data Source
  KAKENHI-PROJECT-16K09594

1. TAKIGAWA Nagio (60325107)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
2. OCHI Nobuaki (80611615)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
3. 中西秀和 (50309548)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
4. KIURA Katsuyuki (10243502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. TABAYASHI Takayuki (60624898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 本多宣裕 (80746876)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 國定俊之 (80346428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yamane Hiromichi 山根 弘路

YAMANE Hiromichi 山根 弘路

Research Projects

Research Products

Co-Researchers

Analysis of drug-resistant cells induced by molecular target agents and prevention of the resistance

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic research for the establishment of adequate sequence of chemotherapy in the treatment of advanced soft tissue sarcomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Overcoming treatment resistance based on metabolic properties of EGFR gene mutations

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the cancer cachexia for the establishment of new treatment modality using the analysis of the iron metabolic pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and overcoming specific signals in EGFR-TKI resistant lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of molecular-targeted drugs on nonsmoking-related lung cancer models

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The complexity of EGFR exon 19 deletion and L858R mutant cells as assessed by proteomics, transcriptomics, and metabolomics2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting ROR1 in combination with osimertinib in EGFR mutant lung cancer cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of (−)-epigallocatechin-3-gallate on EGFR- or Fusion Gene-driven Lung Cancer Cells2017

Author(s)

Journal Title

DOI

NAID

URL

Language

Data Source

[Journal Article] Synergistic effect of pacritinib with erlotinib on JAK2-mediated resistance in epidermal gowth factor receptor mutation-positive non-small cell lung Cancer.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] トラベクテジンによる化学療法が効果的であったFUS/CHOP融合遺伝子陽性粘液型脂肪肉腫患者4症例2024

Author(s)

Organizer

Data Source

[Presentation] EGFRエクソン19欠失とエクソン21 L858R遺伝子変異を有する肺癌細胞株のマルチオミクス解析2023

Author(s)

Organizer

Data Source

[Presentation] A novel molecular target, superoxide dismutase 1, in ALK inhibitor-resistant lung cancer cells, detected through proteomic analysis2023

Author(s)

Organizer

Data Source

[Presentation] EGFR遺伝子変異肺癌におけるROR1標的治療の基礎的検討2021

Author(s)

Organizer

Data Source

Yamane Hiromichi 山根弘路

YAMANE Hiromichi 山根弘路