OCHI Nobuaki 越智宣昭

Researcher Number	80611615
Other IDs
Affiliation (Current)	2023: 川崎医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2012 – 2022: 川崎医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Tumor therapeutics Except Principal Investigator Respiratory organ internal medicine / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 56020:Orthopedics-related / Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator 非小細胞肺癌 / pemetrexed / EGFR-TKI / 耐性 / EGFR / ペメトレキセド / 耐性化 / thymidylate synthase / Drug repositioning / 化学療法 … More / NRTI / TDP-1 / SN-38 / abacavir / ドラッグリポジショニング … More Except Principal Investigator 肺癌 / EGFR / JAK2 / 薬剤耐性 / プロテオーム / mTOR / STAT3 / 遺伝子改変マウス / 血管新生 / ALK / プロテオーム解析 / チロシンキナーゼ阻害 / APOBEC3B / APOBEC / チロシンキナーゼ阻害剤 / 血清フェリチン値 / フェロポルチン / 予後予測モデル / 鉄代謝機構 / 終末期患者予後 / 炎症性マーカー / 鉄代謝 / CRP / フェリチン / 赤血球沈降速度 / 予後相関 / Paps / 予後予測因子 / 固形腫瘍 / がん性悪液質 / ヘプシジン / 血清CRP値 / 炎症性サイトカイン / 軟部肉腫 / 新規抗がん剤 / 治療シークエンス / メタボローム / トランスクリプトーム Less

Basic research for the establishment of adequate sequence of chemotherapy in the treatment of advanced soft tissue sarcoma
- Principal Investigator
  
  山根弘路
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kawasaki Medical School
Overcoming treatment resistance based on metabolic properties of EGFR gene mutations
- Principal Investigator
  
  瀧川奈義夫
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kawasaki Medical School
Study of the cancer cachexia for the establishment of new treatment modality using the analysis of the iron metabolic pathway
- Principal Investigator
  
  Yamane Hiromichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kawasaki Medical School
Identification and overcoming specific signals in EGFR-TKI resistant lung cancer
- Principal Investigator
  
  Takigawa Nagio
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kawasaki Medical School
Drug repositioning of nucleoside reverse transcriptase inhibitor in lung cancerPrincipal Investigator
- Principal Investigator
  
  Ochi Nobuaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kawasaki Medical School
Analysis of pemetrexed-resistant mechanism in EGFR mutation positive non-small cell lung cancerPrincipal Investigator
- Principal Investigator
  
  Ochi Nobuaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kawasaki Medical School
Effects of molecular-targeted drugs on nonsmoking-related lung cancer models
- Principal Investigator
  
  TAKIGAWA Nagio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kawasaki Medical School

All 2021 2020 2017 2016 2014 2013

All Journal Article Presentation

[Journal Article] Targeting ROR1 in combination with osimertinib in EGFR mutant lung cancer cells2021
- Author(s)
  Nakagawa N, Miyake N, Ochi N, Yamane H, Takeyama M, Nagasaki Y, Ikeda T, Yokota E, Fukazawa T, Nakanishi H, Harada D, Kiura K, Takigawa N.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 409 Pages: 112940-112940
- DOI
  10.1016/j.yexcr.2021.112940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08191
[Journal Article] Effects of (-)-epigallocatechin-3-gallate on EGFR- or Fusion Gene-driven Lung Cancer Cells2017
- Author(s)
  Honda Y, Takigawa N, Ichihara E, Ninomiya T, Kubo T, Ochi N, Yasugi M, Murakami T, Yamane H, Tanimoto M, Kiura K.
- Journal Title
  
  Acta Medica Okayama
  
  Volume: 71 Issue: 6 Pages: 505-512
- DOI
  10.18926/AMO/55587
- NAID
  120006370714
- URL
  http://ousar.lib.okayama-u.ac.jp/55587
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09594
[Journal Article] What can we learn from 3 phase III trials of ASCEND-4: ceritinib vs. platinum/pemetrexed with pemetrexed maintenance, PROFILE 1004: crizotinib vs. platinum/pemetrexed, and J-ALEX: alectinib vs. crizotinib?2017
- Author(s)
  Nobuaki Ochi, Nagio Takigawa
- Journal Title
  
  Translational Cancer Research
  
  Volume: 印刷中
- DOI
  10.21037/tcr.2017.04.20
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26830118
[Journal Article] Synergistic effect of pacritinib with erlotinib on JAK2-mediated resistance in epidermal gowth factor receptor mutation-positive non-small cell lung Cancer2016
- Author(s)
  Ochi N, Isozaki H, Takeyama M, Singer JW, Yamane H, Honda Y, Kiura K, Takigawa N.
- Journal Title
  
  Experimental Cell Research
  
  Volume: 344 Pages: 194-200
- DOI
  10.1016/j.yexcr.2016.05.008
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K09594
[Journal Article] Effect of AZD1480 in an epidermal growth factor receptor-driven lung cancer model.2014
- Author(s)
  Ochi N, Takigawa N, Harada D, Yasugi M, Ichihara E, Hotta K, Tabata M, Tanimoto M, Kiura K.
- Journal Title
  
  Experimental Cell Research
  
  Volume: 322 Pages: 168-177
- DOI
  10.1016/j.yexcr.2014.01.007
- NAID
  120005517858
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24591182, KAKENHI-PROJECT-25670399
[Journal Article] Effect of AZD1480 in an epidermal growth factor receptor-driven lung cancer model.2014
- Author(s)
  Murakami Toshi, Takigawa Nagio, Ninomiya Takashi, Ochi Nobuaki, Yasugi Masaaki, Honda Yoshihiro, Kubo Toshio, Ichihara Eiki, Hotta Katsuyuki, Tanimoto Mitsune, Kiura Katsuyuki
- Journal Title
  
  Lung Cancer.
  
  Volume: 83 Pages: 30-36
- DOI
  10.1016/j.lungcan.2013.10.011
- NAID
  120005473065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591182, KAKENHI-PROJECT-25670399
[Journal Article] Src mediates ERK reactivation in gefitinib resistance in non-small cell lung cancer.2014
- Author(s)
  Yasugi M, Takigawa N, Ochi N, Ohashi K, Harada D, Ninomiya T, Murakami T, Honda Y, Ichihara E, Tanimoto M, Kiura K.
- Journal Title
  
  Exp Cell Reｓ
  
  Volume: 326 Pages: 201-209
- DOI
  10.1016/j.yexcr.2014.04.012
- NAID
  120005526613
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24591182, KAKENHI-PROJECT-25670399
[Journal Article] Afatinib prolongs survival compared to gefitinib in an epidermal growth factor receptor-driven lung cancer model2013
- Author(s)
  Ninomiya T, Takigawa N, Ichihara E, Ochi N, Murakami T, Honda Y, Kubo T, Minami D, Kudo K, Tanimoto M, Kiura K.
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 12 Pages: 589-597
- DOI
  10.1158/1535-7163.mct-12-0885
- NAID
  120005359109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-24591182, KAKENHI-PROJECT-25670399
[Presentation] EGFR遺伝子変異肺癌におけるROR1標的治療の基礎的検討2021
- Author(s)
  三宅規子、越智宣昭、中川　望、竹山雅美、山根弘路、長﨑泰有、岩井美樹、横田悦子、深澤拓也、瀧川奈義夫
- Organizer
  第62回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08191
[Presentation] 進行期がん患者における血清炎症性マーカーおよび血清ヘプシジン25濃度と患者予後との関係性について2020
- Author(s)
  山根弘路　越智宜昭　中西秀和　小原弘之　六原純子　瀧川奈義夫
- Organizer
  第25回　日本緩和医療学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07279
[Presentation] 終末期肺がん患者予後に影響する血清炎症性マーカーの検討と新たな予後予測指標の提案2020
- Author(s)
  山根弘路　越智宜昭　中川望　長崎康有　河原辰由樹　市山成彦　田岡征高　三村彩香　小原弘之　瀧川奈義夫
- Organizer
  第61回　日本肺癌学会　学術集会
- Data Source
  KAKENHI-PROJECT-18K07279
[Presentation] ドライバーオンコジーンを有する肺がんに対するエピガロカテキンガレート（EGCG)の効果2017
- Author(s)
  本多宣裕, 瀧川奈義夫, 越智宣昭, 二宮崇, 八杉昌幸, 久保寿夫, 磯崎英子, 市原英基, 堀田勝幸, 山根弘路, 谷本光音, 木浦勝行
- Organizer
  第57回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-16K09594
[Presentation] EGFR遺伝子変異を有する肺癌におけるpemetrexed耐性機構とgefitinib感受性に及ぼす影響2016
- Author(s)
  越智　宣昭
- Organizer
  第56回日本呼吸器学会学術講演会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2016-04-09
- Data Source
  KAKENHI-PROJECT-26830118
[Presentation] EGFR遺伝子変異を有する肺癌におけるpemetrexed耐性機構とgefitinib感受性に及ぼす影響2016
- Author(s)
  越智　宣昭、張　丹、本多　宣裕、山根弘路、谷本光音、木浦勝行、瀧川奈義夫
- Organizer
  第56回日本呼吸器学会学術講演会
- Place of Presentation
  国立京都国際会館（京都市）
- Year and Date
  2016-04-08
- Data Source
  KAKENHI-PROJECT-26830118
[Presentation] PacritinibによるJAK2を介したEGFR-TKI耐性の克服2016
- Author(s)
  越智宣昭、山根弘路、本多宣裕、磯崎英子、木浦勝行、瀧川奈義夫
- Organizer
  第57回日本肺癌学会学術集会
- Place of Presentation
  福岡サンパレス(福岡県福岡市)
- Data Source
  KAKENHI-PROJECT-16K09594
[Presentation] ALK inactivation induced acquired resistance to alectinib in lung cancer harboring EML4-ALK fusion gene2014
- Author(s)
  Isozaki H, Ichihara E, Yasugi M, Ochi N, Hotta K, Takigawa N, Sendo T, Tanimoto M, Kiura K.
- Organizer
  Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  USA, San Diego, San Diego Convention Center
- Year and Date
  2014-04-06
- Data Source
  KAKENHI-PROJECT-24591182
[Presentation] PTEN deficient lung cancer cells are sensitive to the combination of olaparib with cisplatin through suppressing DNA damage signaling2013
- Author(s)
  Minami Daisuke, Takigawa Nagio, Takeda Hiromasa, Takata Minoru, Ochi Nobuaki , Ichihara Eiki, Hisamoto Akiko, Hotta Katsuyuki, Tanimoto Mitsune, Kiura Katsuyuki
- Organizer
  AACR Annual Meeting 2013
- Place of Presentation
  Washington Convention Center, Washington, DC, USA
- Data Source
  KAKENHI-PROJECT-24591182

1. TAKIGAWA Nagio (60325107)

# of Collaborated Projects: 6 results

# of Collaborated Products: 16 results
2. YAMANE Hiromichi (50624897)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
3. 中西秀和 (50309548)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. KIURA Katsuyuki (10243502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. TABAYASHI Takayuki (60624898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 本多宣裕 (80746876)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 國定俊之 (80346428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KUDO Kenichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 堀田勝幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 市原英基

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

OCHI Nobuaki 越智 宣昭

Research Projects

Research Products

Co-Researchers

Basic research for the establishment of adequate sequence of chemotherapy in the treatment of advanced soft tissue sarcoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Overcoming treatment resistance based on metabolic properties of EGFR gene mutations

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the cancer cachexia for the establishment of new treatment modality using the analysis of the iron metabolic pathway

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and overcoming specific signals in EGFR-TKI resistant lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Drug repositioning of nucleoside reverse transcriptase inhibitor in lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of pemetrexed-resistant mechanism in EGFR mutation positive non-small cell lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of molecular-targeted drugs on nonsmoking-related lung cancer models

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Targeting ROR1 in combination with osimertinib in EGFR mutant lung cancer cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of (-)-epigallocatechin-3-gallate on EGFR- or Fusion Gene-driven Lung Cancer Cells2017

Author(s)

Journal Title

DOI

NAID

URL

Language

Data Source

[Journal Article] What can we learn from 3 phase III trials of ASCEND-4: ceritinib vs. platinum/pemetrexed with pemetrexed maintenance, PROFILE 1004: crizotinib vs. platinum/pemetrexed, and J-ALEX: alectinib vs. crizotinib?2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synergistic effect of pacritinib with erlotinib on JAK2-mediated resistance in epidermal gowth factor receptor mutation-positive non-small cell lung Cancer2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of AZD1480 in an epidermal growth factor receptor-driven lung cancer model.2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Effect of AZD1480 in an epidermal growth factor receptor-driven lung cancer model.2014

Author(s)

Journal Title

DOI

NAID

OCHI Nobuaki 越智宣昭