Hashiguchi Takao 橋口隆生

Researcher Number	50632098
Other IDs
Affiliation (Current)	2025: 京都大学, 医生物学研究所, 教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 京都大学, 医生物学研究所, 教授 2020 – 2021: 京都大学, ウイルス・再生医科学研究所, 教授 2016 – 2018: 九州大学, 医学研究院, 准教授 2016: 九州大学, 医学(系)研究科(研究院), 准教授 2013 – 2015: 九州大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related / Virology / Transformative Research Areas, Section (III) / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Pathology, Infection/Immunology, and related fields Except Principal Investigator Medium-sized Section 62:Applied informatics and related fields / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Transformative Research Areas, Section (III) / Biological Sciences
Keywords	Principal Investigator 構造生物学 / ウイルス学 / 構造 / 感染症 / エントリー / 膜融合 / 抗体 / ウイルス / 蛋白質 / 糖鎖生物学 … More / 神経感染 / パラミクソウイルス / 自己・非自己 / PLAMP / 化合物＋ペプチド / 分子デザイン / 感染阻害 / コンピュータ科学 / 構造解析 / 麻疹ウイルス … More Except Principal Investigator 膜融合 / 麻疹ウイルス / 機械学習 / シミュレーション / 情報技術 / 薬物脳内輸送 / DDS / 神経 / 神経細胞 / 亜急性硬化性全脳炎 / 非自己 / 自己 / ライフサイクル / 病原体 / マネジメント / インターフェロン / 生きた病原体 / 新しいパターン / PLAMP / タンパク質 / ヘルペスウイルス / 蛋白質 / 微生物 / 感染症 / 免疫学 / ウイルス Less

パラミクソウイルスの糖鎖受容体認識機構と宿主域・トロピズムの解明Principal Investigator
- Principal Investigator
  
  橋口隆生
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Kyoto University
Transporting drugs across the blood-brain barrier through information technology
- Principal Investigator
  
  黒田大祐
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 62:Applied informatics and related fields
- Research Institution
  The University of Tokyo
Establishing a precision functional molecular design system utilizing a structural informatics approachPrincipal Investigator
- Principal Investigator
  
  Hashiguhi Takao
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kyoto University
Study of mechanisms of viral PLAMP production and PLAMP-mediated regulation of pathogenicityPrincipal Investigator
- Principal Investigator
  
  Hashiguchi Takao
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
Understanding the mechanism of infection dynamics of paramyxoviruses caused by abnormal membrane fusion and its inhibitionPrincipal Investigator
- Principal Investigator
  
  Hashiguchi Takao
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Kyoto University
Management of PLAMP research
- Principal Investigator
  
  YAMAMOTO MASAHIRO
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Osaka University
Mechanism of measles virus spread in the brain
- Principal Investigator
  
  YANAGI Yusuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Nagasaki University
  Kyushu University
A novel approach for antibody design utilizing structural biologyPrincipal Investigator
- Principal Investigator
  
  Hashiguchi Takao
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pathology, Infection/Immunology, and related fields
- Research Institution
  Kyushu University
Structural basis for the mechanisms of virus entry into host cellsPrincipal Investigator
- Principal Investigator
  
  Hashiguchi Takao
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Virology
- Research Institution
  Kyushu University
麻疹ウイルスの細胞侵入・複製・出芽に関わる蛋白質のX線結晶構造解析Principal Investigator
- Principal Investigator
  
  橋口隆生
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Virology
- Research Institution
  Kyushu University
Interplay between viruses and their host cells
- Principal Investigator
  
  Yanagi Yusuke
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 日本の感染症　（麻疹　急性および持続感染機構からワクチンの作用機序まで）2022
- Author(s)
  菅又昌実編　（橋口隆生）
- Total Pages
  264
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-20K20596
[Book] 日本の感染症　（麻疹ー急性および持続感染機構からワクチンの作用機序まで）2022
- Author(s)
  菅又昌実編　橋口隆生
- Total Pages
  264
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-20H03497
[Book] 医学のあゆみ2017
- Author(s)
  久保田万理恵、橋口隆生、柳雄介
- Total Pages
  6
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-26713018
[Book] 実験医学, 第２章10 抗体医薬研究の最前線と展望2015
- Author(s)
  橋口隆生
- Total Pages
  220
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-26713018
[Book] 進化を続ける構造生物学2014
- Author(s)
  松島正明, 伊中浩治, 渡邉信久, 前仲勝実, 橋口隆生, 白石充典, 中川　敦史, 黒木良太, 斎藤稔, 津本浩平, 樋口芳樹, 裏出良博
- Total Pages
  220
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-26713018
[Journal Article] Unveiling the affinity?stability relationship in anti-measles virus antibodies: a computational approach for hotspots prediction2024
- Author(s)
  Paul Rimpa、Kasahara Keisuke、Sasaki Jiei、P?rez Jorge Fern?ndez、Matsunaga Ryo、Hashiguchi Takao、Kuroda Daisuke、Tsumoto Kouhei
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 10 Pages: 1302737-1302737
- DOI
  10.3389/fmolb.2023.1302737
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20596, KAKENHI-PLANNED-19H05766
[Journal Article] 麻疹ウイルスによる中枢神経感染メカニズム2024
- Author(s)
  佐藤裕真、橋口隆生
- Journal Title
  
  医学のあゆみ
  
  Volume: 288 Pages: 1001-1001
- Data Source
  KAKENHI-PROJECT-23K27416
[Journal Article] 麻疹ウイルスによる中枢神経感染メカニズム2024
- Author(s)
  佐藤裕真、橋口隆生
- Journal Title
  
  医学のあゆみ
  
  Volume: 288 Pages: 1001-1001
- Data Source
  KAKENHI-PROJECT-20K20596
[Journal Article] Collective fusion activity determines neurotropism of an en bloc transmitted enveloped virus2023
- Author(s)
  Shirogane Yuta、Harada Hidetaka、Hirai Yuichi、Takemoto Ryuichi、Suzuki Tateki、Hashiguchi Takao、Yanagi Yusuke
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 4 Pages: 1-11
- DOI
  10.1126/sciadv.adf3731
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00507, KAKENHI-PROJECT-20K07527
[Journal Article] Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants2023
- Author(s)
  Kiyomi Shitaoka, Akifumi Higashiura, Yohei Kawano, Akima Yamamoto, Yoko Mizoguchi, Takao Hashiguchi , Norihisa Nishimichi, Shiyu Huang, Ayano Ito, Shun Ohki, Miyuki Kanda, Tomohiro Taniguchi, Rin Yoshizato, Hitoshi Azuma, Yasuo Kitajima, Yasuyuki Yokosaki, Satoshi Okada, Takemasa Sakaguchi, Tomoharu Yasuda
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 1-14
- DOI
  10.1038/s42003-023-04782-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16372, KAKENHI-PLANNED-20H05773, KAKENHI-PROJECT-23K07291, KAKENHI-PROJECT-23K07835, KAKENHI-PROJECT-21K19720, KAKENHI-PROJECT-21K15905, KAKENHI-PROJECT-21H02751
[Journal Article] Interaction of the hemagglutinin stalk region with cell adhesion molecule (CADM) 1 and CADM2 mediates the spread between neurons and neuropathogenicity of measles virus with a hyperfusogenic fusion protein2023
- Author(s)
  Takemoto Ryuichi, Hirai Yuichi, Watanabe Shumpei, Harada Hidetaka, Suzuki Tateki, Hashiguchi Takao, Yanagi Yusuke, Shirogane Yuta
- Journal Title
  
  Journal of Virology
  
  Volume: 97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00507
[Journal Article] Short-Stalk Isoforms of CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Interacting with the Viral Hemagglutinin2022
- Author(s)
  Takemoto Ryuichi、Suzuki Tateki、Hashiguchi Takao、Yanagi Yusuke、Shirogane Yuta
- Journal Title
  
  Journal of Virology
  
  Volume: 96 Issue: 3 Pages: 1-18
- DOI
  10.1128/jvi.01949-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00507, KAKENHI-PROJECT-20K07527
[Journal Article] Application of Acoustic Ejection MS System to High-Throughput Screening for SARS-CoV-2 3CL Protease Inhibitors2022
- Author(s)
  Hasegawa Tsukasa、Imamura Riyo M.、Suzuki Tateki、Hashiguchi Takao、Nomura Takao、Otsuguro Satoko、Maenaka Katsumi、Sasaki Michihito、Orba Yasuko、Sawa Hirofumi、Sato Akihiko、Okabe Takayoshi、Nagano Tetsuo、Kojima Hirotatsu
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 70 Issue: 3 Pages: 199-201
- DOI
  10.1248/cpb.c21-01003
- NAID
  130008165547
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2022-03-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03497, KAKENHI-PLANNED-20H05773
[Journal Article] Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant2022
- Author(s)
  Saito et al.
- Journal Title
  
  Cell Host & Microbe
  
  Volume: 30 Issue: 11 Pages: 1540-1540
- DOI
  10.1016/j.chom.2022.10.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0447, KAKENHI-PROJECT-22KK0148, KAKENHI-PLANNED-20H05773, KAKENHI-PROJECT-19H01171, KAKENHI-PROJECT-21H02736, KAKENHI-PROJECT-21H03802, KAKENHI-PROJECT-22KJ0809, KAKENHI-PROJECT-22KJ1862, KAKENHI-PROJECT-21K19878, KAKENHI-PROJECT-23K24378
[Journal Article] Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.52022
- Author(s)
  Kimura et al.
- Journal Title
  
  Cell
  
  Volume: 185 Issue: 21 Pages: 3992-4007
- DOI
  10.1016/j.cell.2022.09.018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0447, KAKENHI-PLANNED-20H05773, KAKENHI-PROJECT-19H01171, KAKENHI-PROJECT-21H02736, KAKENHI-PROJECT-21H03802, KAKENHI-PROJECT-22KJ0023, KAKENHI-PROJECT-22KJ0809, KAKENHI-PROJECT-21K19878
[Journal Article] Viral Biophysics: Contributions to Drug Modalities2021
- Author(s)
  MAENAKA Katsumi、FUKUHARA Hideo、HASHIGUCHI Takao、CAAVEIRO Jose M. M.、NAGATOISHI Satoshi、KURODA Daisuke、TSUMOTO Kouhei
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 61 Issue: 2 Pages: 082-089
- DOI
  10.2142/biophys.61.082
- NAID
  130008002753
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-20K20596, KAKENHI-PLANNED-20H05773, KAKENHI-PROJECT-20H03497
[Journal Article] The physiological TMPRSS2 inhibitor HAI-2 alleviates SARS-CoV-2 infection2021
- Author(s)
  Tomita Yuriko、Matsuyama Shutoku、Fukuhara Hideo、Maenaka Katsumi、Kataoka Hiroaki、Hashiguchi Takao、Takeda Makoto
- Journal Title
  
  Journal of Virology
  
  Volume: 95 Issue: 12
- DOI
  10.1128/jvi.00434-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07519, KAKENHI-PLANNED-20H05773, KAKENHI-PROJECT-18H02665
[Journal Article] 構造生物学的手法による麻疹・ムンプスウイルスの細胞侵入及び侵入阻害機構の研究2021
- Author(s)
  橋口隆生
- Journal Title
  
  生体の科学
  
  Volume: 72 Pages: 335-338
- Data Source
  KAKENHI-PROJECT-20K20596
[Journal Article] Characterization of Natural and Synthetic Sialoglycans Targeting the Hemagglutinin-Neuraminidase of Mumps Virus2021
- Author(s)
  Forgione Rosa Ester、Di Carluccio Cristina、Milanesi Francesco、Kubota Marie、Fabregat Nieto Ferran、Molinaro Antonio、Hashiguchi Takao、Francesconi Oscar、Marchetti Roberta、Silipo Alba
- Journal Title
  
  Frontiers in Chemistry
  
  Volume: 9 Pages: 711346-711346
- DOI
  10.3389/fchem.2021.711346
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20596, KAKENHI-PLANNED-20H05773
[Journal Article] Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-192021
- Author(s)
  Kaku Y, Kuwata T, Zahid HM, Hashiguchi T, Noda T, Kuramoto N, Biswas S, Matsumoto K, Shimizu M, Kawanami Y, Shimura K, Onishi C, Muramoto Y, Suzuki T, Sasaki J, Nagasaki Y, Minami R, Motozono C, Toyoda M, Takahashi H, Kishi H, Fujii K, Tatsuke T, Ikeda T, Maeda Y, Ueno T, Koyanagi Y, Iwagoe H, Matsushita S.
- Journal Title
  
  Cell Reports
  
  Volume: 36 Issue: 2 Pages: 109385-109385
- DOI
  10.1016/j.celrep.2021.109385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06401, KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-19K08932, KAKENHI-PROJECT-20K20596, KAKENHI-PLANNED-20H05773
[Journal Article] 構造生物学的手法による麻疹・ムンプスウイルスの細胞侵入及び侵入阻害機構の研究2021
- Author(s)
  橋口隆生
- Journal Title
  
  生体の科学
  
  Volume: 72 Pages: 335-338
- Data Source
  KAKENHI-PROJECT-20H03497
[Journal Article] Unique Tropism and Entry Mechanism of Mumps Virus2021
- Author(s)
  Kubota Marie、Hashiguchi Takao
- Journal Title
  
  Viruses
  
  Volume: 13 Issue: 9 Pages: 1746-1746
- DOI
  10.3390/v13091746
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03497, KAKENHI-PLANNED-20H05773
[Journal Article] CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Acting in <i>cis</i>2021
- Author(s)
  Shirogane Yuta、Takemoto Ryuichi、Suzuki Tateki、Kameda Tomonori、Nakashima Kinichi、Hashiguchi Takao、Yanagi Yusuke
- Journal Title
  
  Journal of Virology
  
  Volume: 95 Issue: 14 Pages: 1-17
- DOI
  10.1128/jvi.00528-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00507, KAKENHI-PROJECT-20K07527
[Journal Article] Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypes2021
- Author(s)
  Ikegame Satoshi、Hashiguchi Takao、Hung Chuan-Tien、Dobrindt Kristina、Brennand Kristen J.、Takeda Makoto、Lee Benhur
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 18
- DOI
  10.1073/pnas.2026027118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03497, KAKENHI-PLANNED-20H05773, KAKENHI-PROJECT-23K21381
[Journal Article] A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site2021
- Author(s)
  Onodera T, Kita S, Adachi Y, Moriyama S, Sato A, Nomura T, Sakakibara S, Inoue T, Tadokoro T, Anraku Y, Yumoto K, Tian C, Fukuhara H, Sasaki M, Orba Y, Shiwa N, Iwata N, Nagata N, Suzuki T, others, and Takahashi Y
- Journal Title
  
  Immunity
  
  Volume: 54 Issue: 10 Pages: 2385-2398
- DOI
  10.1016/j.immuni.2021.08.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21666, KAKENHI-PROJECT-19KK0178, KAKENHI-PLANNED-20H05773
[Journal Article] ムンプスウイルス糖鎖受容体とその認識機構2021
- Author(s)
  橋口隆生
- Journal Title
  
  ウイルス
  
  Volume: 71 Pages: 185-190
- Data Source
  KAKENHI-PROJECT-20H03497
[Journal Article] Large-Scale Expression and Purification of Mumps Virus Hemagglutinin-Neuraminidase for Structural Analyses and Glycan-Binding Assays2020
- Author(s)
  Kubota Marie、Hashiguchi Takao
- Journal Title
  
  Methods Mol Biol.
  
  Volume: - Pages: 641-652
- DOI
  10.1007/978-1-0716-0430-4_55
- ISBN
  9781071604298, 9781071604304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20596, KAKENHI-PROJECT-20H03497
[Journal Article] Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.2017
- Author(s)
  Sangha AK, Dong J, Williamson L, Hashiguchi T, Saphire EO, Crowe JE Jr, Meiler J.
- Journal Title
  
  Structure
  
  Volume: 25(12) Issue: 12 Pages: 1820-1828
- DOI
  10.1016/j.str.2017.10.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19562
[Journal Article] Trisaccharide containing alpha2,3-linked sialic acid is a receptor for mumps virus2016
- Author(s)
  Kubota M, Takeuchi K, Watanabe S, Ohno S, Matsuoka R, Kohda D, Nakakita S, Hiramatsu H, Suzuki Y, Nakayama T, Terada T, Shimizu K, Shimizu N, Shiroishi M, Yanagi Y, Hashiguchi T
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 113 Issue: 41 Pages: 11579-11584
- DOI
  10.1073/pnas.1608383113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-24115005, KAKENHI-PROJECT-15J05685, KAKENHI-PROJECT-26713018
[Journal Article] Mechanism of human antibody-mediated neutralization of Marburg virus.2015
- Author(s)
  Flyak AI, Ilinykh PA, Murin CD, Garron T, Shen X, Fusco ML, Hashiguchi T, Bornholdt ZA, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Ward AB, Saphire EO, Bukreyev A, and Crowe JE Jr.
- Journal Title
  
  Cell
  
  Volume: 160 Issue: 5 Pages: 893-903
- DOI
  10.1016/j.cell.2015.01.031
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26713018
[Journal Article] Structural Basis for Marburg Virus Neutralization by a Cross-Reactive Human Antibody2015
- Author(s)
  Hashiguchi T, Fusco ML, Bornholdt ZA, Lee JE, Flyak AI, Matsuoka R, Kohda D, Yanagi Y, Hammel M, Crowe JE, Saphire EO
- Journal Title
  
  Cell
  
  Volume: 160 Issue: 5 Pages: 904-912
- DOI
  10.1016/j.cell.2015.01.041
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-24115005, KAKENHI-PROJECT-26713018
[Presentation] 新型コロナウイルス変異株による受容体認識・中和抗体逃避の構造基盤と構造情報を活用した蛋白質デザイン2023
- Author(s)
  橋口隆生
- Organizer
  SAMURAI研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K20596
[Presentation] X-206はSARS-CoV-2変異株および各種薬剤耐性株に対して広域かつ強力な感染阻害作用を示す2023
- Author(s)
  佐々木慈英、岡部伊織、佐藤彰彦、児玉耕太、乙黒聡子、佐々木道仁、大場靖子、澤洋文、前仲勝実、栁雄介、橋口隆生
- Organizer
  第70回日本ウイルス学会学術総会
- Data Source
  KAKENHI-PROJECT-20K20596
[Presentation] 原子の世界でウイルスを視る、制御する2023
- Author(s)
  橋口隆生
- Organizer
  京都大学医生物学研究所第17回公開講演会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27416
[Presentation] 原子の世界でウイルスを視る、制御する2023
- Author(s)
  橋口隆生
- Organizer
  京都大学医生物学研究所第17回公開講演会
- Invited
- Data Source
  KAKENHI-PROJECT-20K20596
[Presentation] Viral pathogenesis and pharmaceutical studies for viral infectious diseases utilizing protein science2023
- Author(s)
  Hashiguchi T
- Organizer
  Advanced Seminar Series on Microbiology and Immunology
- Invited
- Data Source
  KAKENHI-PROJECT-20H03497
[Presentation] 新型コロナウイルス変異株による受容体への親和性増強および抗体逃避の構造基盤2023
- Author(s)
  橋口隆生
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K20596
[Presentation] Viral pathogenesis and pharmaceutical studies for viral infectious diseases utilizing protein science2023
- Author(s)
  Hashiguchi T
- Organizer
  Advanced Seminar Series on Microbiology and Immunology
- Invited
- Data Source
  KAKENHI-PROJECT-20K20596
[Presentation] 新型コロナウイルス変異株による受容体認識・中和抗体逃避の構造基盤および創薬展開2022
- Author(s)
  橋口隆生
- Organizer
  2022年度量子ビームサイエンスフェスタ
- Invited
- Data Source
  KAKENHI-PLANNED-20H05773
[Presentation] Cooperation and Interference between Wild-type and Subacute Sclerosing Panencephalitis-derived Measles Virus Fusion Proteins2022
- Author(s)
  Hidetaka Harada, Ryuichi Takemoto, Yuichi Hirai, Tateki Suzuki, Takao Hashiguchi, Yusuke Yanagi, Yuta Shirogane
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00507
[Presentation] 蛋白質精製技術を活用したコロナウイルス研究2022
- Author(s)
  橋口隆生
- Organizer
  第95回日本細菌学会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05773
[Presentation] Alanine substitutions reveal residues in the stalk region of the measles virus hemagglutinin required for CADM1/2-dependent membrane fusion2022
- Author(s)
  Ryuichi Takemoto, Yuichi Hirai, Tateki Suzuki, Takao Hashiguchi, Yusuke Yanagi, Yuta Shirogane
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00507
[Presentation] Glycan receptor and entry mechanism of mumps virus2022
- Author(s)
  Hashiguchi T
- Organizer
  Sialoglyco2022,
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03497
[Presentation] Molecular mechanism of neutralization of a pan-SARS-CoV-2 antibody and ACE2-receptor recognition by BA.4/5 variants2022
- Author(s)
  Hashiguchi T
- Organizer
  The 20th Awaji International Forum on Infection and Immunity (AIFII 20)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05773
[Presentation] Fusion proteins derived from some SSPE measles virus isolates cause membrane fusion independently of SLAM, nectin-4, and CADM1/22022
- Author(s)
  Yuichi Hirai, Ryuichi Takemoto,Tateki Suzuki, Takao Hashiguchi, Yusuke Yanagi, Yuta Shirogane
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00507
[Presentation] Glycan receptor and entry mechanism of mumps virus2022
- Author(s)
  Hashiguchi T
- Organizer
  Sialoglyco2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20596
[Presentation] Cell adhesion molecule（CADM）１およびCADM2のストークの短いアイソフォームが神経病原性を有する麻疹ウイルスによる膜融合を誘導する2021
- Author(s)
  Ryuichi Takemoto, Tateki Suzuki, Takao Hashiguchi, Yusuke Yanagi, Yuta Shirogane
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00507
[Presentation] 麻疹ウイルスによる神経感染症の分子メカニズム2021
- Author(s)
  橋口隆生
- Organizer
  第 25 回日本神経感染症学会総会・学術大会
- Invited
- Data Source
  KAKENHI-PLANNED-20H05773
[Presentation] Structural biology of human pathogenic RNA viruses2021
- Author(s)
  Hashiguchi T
- Organizer
  UCLA-KU seminar series
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03497
[Presentation] 麻疹ウイルスによる神経感染症の分子メカニズム2021
- Author(s)
  橋口隆生
- Organizer
  第 25 回日本神経感染症学会総会・学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03497
[Presentation] Structural biology of human pathogenic RNA viruses2021
- Author(s)
  Hashiguchi T
- Organizer
  UCLA-KU seminar series
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05773
[Presentation] コロナウイルス研究のための蛋白質科学プラットフォームの構築2021
- Author(s)
  橋口隆生
- Organizer
  第41回阿蘇シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-20H05773
[Presentation] Molecular mechanism of glycan receptor recognition by mumps virus2021
- Author(s)
  Hashiguchi T
- Organizer
  The 27th East Asia Joint Symposium (EAJS)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05773
[Presentation] Molecular mechanism of glycan receptor recognition by mumps virus2021
- Author(s)
  Hashiguchi T
- Organizer
  The 27th East Asia Joint Symposium (EAJS)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20596
[Presentation] Molecular mechanism of glycan receptor recognition by mumps virus2021
- Author(s)
  Hashiguchi T
- Organizer
  The 27th East Asia Joint Symposium (EAJS)
- Invited
- Data Source
  KAKENHI-PROJECT-20H03497
[Presentation] Structural biology of human pathogenic RNA viruses2021
- Author(s)
  Hashiguchi T
- Organizer
  UCLA-KU seminar series
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20596
[Presentation] 麻疹ウイルスによる神経感染症の分子メカニズム2021
- Author(s)
  橋口隆生
- Organizer
  第 25 回日本神経感染症学会総会・学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K20596
[Presentation] Cell adhesion molecule (CADM) 1 and CADM2 enable measles virus spread in subacute sclerosing panencephalitis by cis-acting fusion triggering2021
- Author(s)
  Yuta Shirogane, Ryuichi Takemoto, Tateki Suzuki, Tomonori Kameda, Kinichi Nakashima,Takao Hashiguchi, Yusuke Yanagi
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00507
[Presentation] Glycan receptors for mumps virus and other paramyxoviruses2020
- Author(s)
  Hashiguchi T
- Organizer
  2020 Society for Glycobiology Virtual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05773
[Presentation] Identify and interrogating the functional constraints that contribute to the lack of antigenic drift in paramyxoviruses.2020
- Author(s)
  Satoshi Ikegame, Kasopefoluwa Oguntuyo, Takao Hashiguchi, Makoto Takeda, Benhur Lee
- Organizer
  American Society for Virology (ASV) 39th Annual Meeting
- Data Source
  KAKENHI-PROJECT-20K20596
[Presentation] Identify and interrogating the functional constraints that contribute to the lack of antigenic drift in paramyxoviruses.2020
- Author(s)
  Satoshi Ikegame, Kasopefoluwa Oguntuyo, Takao Hashiguchi, Makoto Takeda, Benhur Lee
- Organizer
  American Society for Virology (ASV) 39th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03497
[Presentation] Identify and interrogating the functional constraints that contribute to the lack of antigenic drift in paramyxoviruses.2020
- Author(s)
  Satoshi Ikegame, Kasopefoluwa Oguntuyo, Takao Hashiguchi, Makoto Takeda, Benhur Lee
- Organizer
  American Society for Virology (ASV) 39th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05773
[Presentation] Glycan receptors for mumps virus and other paramyxoviruses2020
- Author(s)
  Hashiguchi T
- Organizer
  2020 Society for Glycobiology Virtual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03497
[Presentation] Glycan receptors for mumps virus and other paramyxoviruses2020
- Author(s)
  Hashiguchi T
- Organizer
  2020 Society for Glycobiology Virtual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20596
[Presentation] Structure-guided and computer-aided drug development to ameliorate persistent measles virus infection in the central nervous system2019
- Author(s)
  Hashiguchi T
- Organizer
  Japan-UK Workshop on Infectious Disease Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19562
[Presentation] 小児ウイルス感染症とその感染阻害機構2019
- Author(s)
  橋口隆生
- Organizer
  第５回外力支援型バイオアッセイ技術コンソーシアム技術セミナー・技術交流会（産総研）
- Invited
- Data Source
  KAKENHI-PROJECT-17K19562
[Presentation] Molecular dissection of virus entry and its inhibition by antibodies/inhibitors2018
- Author(s)
  Takao Hashiguchi
- Organizer
  Immunology at the Forefront - The 9th International Symposium of IFReC
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19562
[Presentation] モノネガウイルスの細胞侵入およびその阻害機構の研究と創薬への展開2018
- Author(s)
  橋口隆生
- Organizer
  新興再興感染症制御プロジェクト　新興再興事業・J-GRID合同シンポジウム感染症研究連携のフロンティア
- Invited
- Data Source
  KAKENHI-PROJECT-17K19562
[Presentation] おたふくかぜ・麻疹（はしか）の感染制御に向けて2018
- Author(s)
  橋口隆生
- Organizer
  埼玉大学先端産業国際ラボラトリー第8回ワークショップ-感染症に挑む
- Invited
- Data Source
  KAKENHI-PROJECT-17K19562
[Presentation] 原子の世界でウイルスを視る、制御する2018
- Author(s)
  橋口隆生
- Organizer
  ラブラボ 2018
- Invited
- Data Source
  KAKENHI-PROJECT-17K19562
[Presentation] 糖鎖受容体を介したムンプスウイルス細胞侵入メカニズムの構造生物学的・ウイルス学的解析2017
- Author(s)
  橋口隆生
- Organizer
  6th Negative Strand Virus-Japan
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-26713018
[Presentation] 構造生物学的手法を活用したRNAウイルスの細胞侵入機構および抗体による中和機構の研究2017
- Author(s)
  橋口隆生
- Organizer
  第4回タンパク質X線溶液散乱講習会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19562
[Presentation] X線結晶構造に基づくパラミクソウイルスの細胞侵入および抗体による中和機構と予防・治療法への展開2017
- Author(s)
  橋口隆生
- Organizer
  第160回日本獣医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19562
[Presentation] Molecular basis for Mononegavirus entry and inhibitions by antibodies/inhibitors2017
- Author(s)
  Takao Hashiguchi
- Organizer
  The 16th Awaji International Forum on Infection and Immunity (AIFII 16)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19562
[Presentation] 中和抗体によるエボラ・マールブルグウイルスの侵入阻害機構2016
- Author(s)
  橋口隆生
- Organizer
  第136回日本薬学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-26713018
[Presentation] Linear saccharide moiety containing α2,3-linked sialic acid, rather than the sialic acid alone, constitutes a receptor for mumps virus2016
- Author(s)
  Marie Kubota, Kaoru Takeuchi, Shumpei Watanabe, Shinji Ohno, Rei Matsuoka, Daisuke Kohda, Shin-ichi Nakakita, Hiroaki Hiramatsu, Yasuo Suzuki, Tetsuo Nakayama, Tohru Terada, Kentaro Shimizu, Nobutaka Shimizu, Yusuke Yanagi, Takao Hashiguchi.
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-26713018
[Presentation] ムンプスウイルスのHN蛋白質へッドメインの四量体化が膜融合に重要である2016
- Author(s)
  Iori Okabe, Marie Kubota, Shin-ichi Nakakita, Takao Hashiguchi, Yusuke Yanagi
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PLANNED-24115005
[Presentation] Molecular basis for negative-strand RNA virus entry and neutralization by antibodies.2016
- Author(s)
  Takao Hashiguchi
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-26713018
[Presentation] 抗体によるエボラ・マールブルグウイルスの中和機構2016
- Author(s)
  橋口隆生、柳雄介、松岡礼、神田大輔、Erica Ollmann Saphire
- Organizer
  第16回日本蛋白質科学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-26713018
[Presentation] アルファ2，3結合型シアル酸を含む末端三糖がムンプスウイルスの機能的受容体である2016
- Author(s)
  Marie Kubota, Kaoru Takeuchi, Shumpei Watanabe, Shinji Ohno, Rei Matsuoka, Daisuke Kohda, Shin-ichi Nakakita, Hiroaki Hiramatsu, Yasuo Suzuki, Tetsuo Nakayama, Tohru Terada, Kentaro Shimizu, Nobutaka Shimizu, Yusuke Yanagi, Takao Hashiguchi
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PLANNED-24115005
[Presentation] Tetrameric interaction of the mumps virus hemagglutinin-neuraminidase head domain is critical for triggering membrane fusion.2016
- Author(s)
  Iori Okabe, Marie Kubota, Shin-ichi Nakakita, Takao Hashiguchi, Yusuke Yanagi.
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-26713018
[Presentation] Characterization of Neutralizing Antibodies against Measles Virus2016
- Author(s)
  Yoshinari Fukuda, Takao Hashiguchi, Shinji Ohno, Yusuke Yanagi
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-26713018
[Presentation] 抗体によるフィロウイルスの中和の構造基盤2015
- Author(s)
  橋口隆生
- Organizer
  感染症国際研究センター/全国共同利用・共同研究拠点若手ジョイントシンポジウム（東京大学医科学研究所）
- Place of Presentation
  東京
- Year and Date
  2015-02-18
- Invited
- Data Source
  KAKENHI-PROJECT-26713018
[Presentation] Structural basis of the interaction between mumps virus HN protein and its receptor2015
- Author(s)
  Kubota M, Hashiguchi T, Watanabe S, Ohno S, Matsuoka R, Nakayama T,Hiramatsu H, Suzuki S, Yanagi Y, Takeuchi K
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2015-11-23
- Data Source
  KAKENHI-PLANNED-24115005
[Presentation] マールブルグウイルス糖蛋白質GPとヒト由来抗体のX線結晶構造2014
- Author(s)
  橋口隆生、柳　雄介、 Erica Ollmann Saphire
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-11-10
- Data Source
  KAKENHI-PLANNED-24115005
[Presentation] Structures of measles virus hemagglutinin provide virus entry and effective measles vaccine2013
- Author(s)
  Takao Hashiguchi, Mai Nakashima, Yuta Shirogane, Katsumi Maenaka, Yusuke Yanagi
- Organizer
  The 12th Awaji International Forum on Infection and Immunity
- Place of Presentation
  淡路
- Invited
- Data Source
  KAKENHI-PROJECT-25893161
[Presentation] Structures of measles virus hemagglutinin provide virus entry and effective measles vaccine
- Author(s)
  Hashiguchi T, Nakashima M, Shirogane Y, Maenaka K, and Yanagi Y
- Organizer
  The 12th Awaji International Forum on Infection and Immunity
- Place of Presentation
  淡路
- Invited
- Data Source
  KAKENHI-PLANNED-24115005
[Presentation] モノネガウイルスワクチンの有効性と新規開発の構造基盤
- Author(s)
  橋口隆生
- Organizer
  「感染・炎症・免疫・発癌」(北海道大学遺伝子病制御研究所)
- Place of Presentation
  札幌
- Year and Date
  2014-07-03 – 2014-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-26713018
[Presentation] マールブルグウイルス糖蛋白質 GP とヒト由来抗体の X 線結晶構造
- Author(s)
  橋口隆生、柳雄介、Erica Ollmann Saphire
- Organizer
  第62回　日本ウイルス学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26713018

1. Yanagi Yusuke (40182365)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
2. 黒田大祐 (60756732)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SUENAGA Tadahiro (20396675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YAMAMOTO MASAHIRO (00444521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 荒瀬尚 (10261900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 大野真治 (50419529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 新崎恒平 (70609990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 白銀勇太 (40756988)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
9. 安楽泰孝 (60581585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 松山州徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 村本裕紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 下岡清美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 永田典代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hashiguchi Takao 橋口 隆生

Research Projects

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パラミクソウイルスの糖鎖受容体認識機構と宿主域・トロピズムの解明Principal Investigator

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Transporting drugs across the blood-brain barrier through information technology

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Establishing a precision functional molecular design system utilizing a structural informatics approachPrincipal Investigator

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Study of mechanisms of viral PLAMP production and PLAMP-mediated regulation of pathogenicityPrincipal Investigator

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Understanding the mechanism of infection dynamics of paramyxoviruses caused by abnormal membrane fusion and its inhibitionPrincipal Investigator

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Management of PLAMP research

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Mechanism of measles virus spread in the brain

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A novel approach for antibody design utilizing structural biologyPrincipal Investigator

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Structural basis for the mechanisms of virus entry into host cellsPrincipal Investigator

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麻疹ウイルスの細胞侵入・複製・出芽に関わる蛋白質のX線結晶構造解析Principal Investigator

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Interplay between viruses and their host cells

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[Book] 日本の感染症 （麻疹 急性および持続感染機構からワクチンの作用機序まで）2022

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Total Pages

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Data Source

[Book] 日本の感染症 （麻疹ー急性および持続感染機構からワクチンの作用機序まで）2022

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Total Pages

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Data Source

Hashiguchi Takao 橋口隆生

[Book] 日本の感染症　（麻疹　急性および持続感染機構からワクチンの作用機序まで）2022

[Book] 日本の感染症　（麻疹ー急性および持続感染機構からワクチンの作用機序まで）2022