SHIRAKAMI Yohei 白上洋平

Researcher Number	50632816
Other IDs
Affiliation (Current)	2025: 岐阜大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2025: 岐阜大学, 医学部附属病院, 講師 2021 – 2023: 岐阜大学, 医学部附属病院, 講師 2019 – 2020: 岐阜大学, 医学部附属病院, 助教 2015 – 2018: 岐阜大学, 大学院医学系研究科, 助教 2013 – 2015: 岐阜大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology / Laboratory medicine
Keywords	Principal Investigator 脂肪肝 / レチノイド / 肝内胆管癌 / 肥満 / レチノイド / 胆管癌 / シグナル伝達 / 脂質 / 内科 / 耐糖能 … More / NAFLD / 糖尿病 / 非アルコール性脂肪性肝炎 / 糖代謝 / NASH / インスリン抵抗性 … More Except Principal Investigator サルコペニア / 肥満 / 骨格筋 / 肝硬変 / 老化 / 診療ガイドライン / 大腸癌予防 / DNAメチル化 / メチル化 / 糖尿病 / 大腸癌 / サルコぺニア / 肝発癌 / 慢性肝疾患 / 肝発癌予防 / 肝不全 / 肝筋相関 / 握力 / レチノイド / 核内受容体RXR / 非アルコール性脂肪肝炎 / 生活習慣病 / 臓器間ネットワーク / メタボ肝癌 / 癌進展 / 癌免疫療法 / インドールアミン酸素添加酵素 / 癌転移 / ＮＫＴ細胞 / 免疫抑制因子 / 一酸化窒素 / 腫瘍免疫 / NKT細胞 Less

レチノイドシグナル阻害による新規マウス胆管癌モデルの開発と治療薬の探索Principal Investigator
- Principal Investigator
  
  白上洋平
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Gifu University
診療ガイドラインの検証と老化モデルの解析に基づく高齢肝硬変患者の包括的治療戦略
- Principal Investigator
  
  清水雅仁
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Gifu University
Novel mouse models of cholangiocarcinoma focusing on retinoid signaling and fatty liverPrincipal Investigator
- Principal Investigator
  
  白上洋平
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Gifu University
Molecular abnormalities and DNA methylation in obesity-related colorectal carcinogenesis
- Principal Investigator
  
  Kubota Masaya
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Gifu University
Liver failure and liver carcinogenesis prevention by liver-skeletal muscle correlation control
- Principal Investigator
  
  SHIRAKI MAKOTO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Gifu University
Comprehensive treatment strategy for chronic liver disease patients based on body composition analysis
- Principal Investigator
  
  SHIMIZU MASAHITO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Gifu University
Establishment of new mouse models for investigating the effect of fatty liver on intrahepatic bile duct cancer developmentPrincipal Investigator
- Principal Investigator
  
  Shirakami Yohei
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Gifu University
Development of the innovative chemopreventive strategy for metabolic syndrome-related liver carcinogenesis by targeting multiple organ network
- Principal Investigator
  
  Shimizu Masahito
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Elucidation of the pathological condition of non-alcoholic fatty liver disease regarding retinoid receptor signalingPrincipal Investigator
- Principal Investigator
  
  Shirakmai Yohei
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Relationship between non-alcoholic fatty liver disease and hepatic retinoid signalingPrincipal Investigator
- Principal Investigator
  
  Shirakami Yohei
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Gifu University
Inhibition of iNOS activity enhances the anti-tumor effects of alpha-galactosylceramide in cancer model
- Principal Investigator
  
  Ito Hiroyasu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Gifu University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation Book

[Book] 臨床検査ガイド2015年改訂版2015
- Author(s)
  白上洋平，清水雅仁．
- Total Pages
  1154
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-26860498
[Book] 臨床検査ガイド　2015年改訂版2015
- Author(s)
  白上洋平，清水雅仁．
- Total Pages
  1176
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-26860498
[Journal Article] Serum MYCN as a predictive biomarker of prognosis and therapeutic response in the prevention of hepatocellular carcinoma recurrence2024
- Author(s)
  Qin XY, Shirakami Y, Honda M, Yeh SH, Numata K, Lai YY, Li CL, Wei F, Xu Y, Imai K, Takai K, Chuma M, Komatsu N, Furutani Y, Gailhouste L, Aikata H, Chayama K, Enomoto M, Tateishi R, Kawaguchi K, Yamashita T, Kaneko S, Nagaoka K, Tanaka M, Sasaki Y, Tanaka Y, Baba H, Miura K, Ochi S, Masaki T, et al
- Journal Title
  
  International Journal of Cancer
  
  Volume: － Issue: 3 Pages: 582-594
- DOI
  10.1002/ijc.34893
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08342, KAKENHI-PROJECT-21K07892, KAKENHI-PROJECT-22K08724, KAKENHI-PROJECT-20K07349, KAKENHI-PROJECT-21K07904, KAKENHI-PROJECT-21K07940
[Journal Article] Animal naming test stratifies the risk of falls and fall-related fractures in patients with cirrhosis2024
- Author(s)
  Miwa T, Hanai T, Hirata S, Nishimura K, Unome S, Nakahata Y, et al
- Journal Title
  
  Sci Rep
  
  Volume: 14 Issue: 1 Pages: 4307-4307
- DOI
  10.1038/s41598-024-54951-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15919, KAKENHI-PROJECT-21K07892
[Journal Article] Editorial: Cancer and nutrients: new chemicals, signals, and biomarker-based therapy2023
- Author(s)
  Qin Xian-Yang、Mendoza-Parra Marco Antonio、Shirakami Yohei
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 13 Pages: 190065-190065
- DOI
  10.3389/fonc.2023.1190065
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07349, KAKENHI-PROJECT-21K07892
[Journal Article] Targeting transglutaminase 2 mediated exostosin glycosyltransferase 1 signaling in liver cancer stem cells with acyclic retinoid2023
- Author(s)
  Qin XY, Furutani Y, Yonezawa K, Shimizu N, Kato-Murayama M, Shirouzu M, Xu Y, Yamano Y, Wada A, Gailhouste L, Shrestha R, Takahashi M, Keillor JW, Su T, Yu W, Fujii S, Kagechika H, Dohmae N, Shirakami Y, Shimizu M, Masaki T, Matsuura T, Suzuki H, Kojima S
- Journal Title
  
  Cell Death & Disease
  
  Volume: 14 Issue: 6 Pages: 358-358
- DOI
  10.1038/s41419-023-05847-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08342, KAKENHI-PROJECT-21K07892, KAKENHI-PROJECT-22K08067, KAKENHI-PROJECT-20K07349
[Journal Article] Skeletal muscle atrophy is exacerbated by steatotic and fibrotic liver‐derived TNF‐α in senescence‐accelerated mice2023
- Author(s)
  Shirakami Yohei、Kato Junichi、Maeda Toshihide、Ideta Takayasu、Imai Kenji、Sakai Hiroyasu、Shiraki Makoto、Shimizu Masahito
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 38 Issue: 5 Pages: 800-808
- DOI
  10.1111/jgh.16171
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07892, KAKENHI-PROJECT-23K07433
[Journal Article] A Novel Mouse Model of Intrahepatic Cholangiocarcinoma Induced by Azoxymethane2023
- Author(s)
  Shirakami Yohei、Kato Junichi、Ohnishi Masaya、Taguchi Daisuke、Maeda Toshihide、Ideta Takayasu、Kubota Masaya、Sakai Hiroyasu、Tomita Hiroyuki、Tanaka Takuji、Shimizu Masahito
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 19 Pages: 14581-14581
- DOI
  10.3390/ijms241914581
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07892, KAKENHI-PROJECT-23K07433, KAKENHI-PROJECT-20K08284
[Journal Article] The phosphorylated retinoid X receptor-α promotes diethylnitrosamine-induced hepatocarcinogenesis in mice through the activation of β-catenin signaling pathway.2022
- Author(s)
  Sakai H, Yamada Y, Kubota M, Imai K, Shirakami Y, Tomita H, Hara A, Shimizu M.
- Journal Title
  
  Carcinogenesis.
  
  Volume: 43 Issue: 3 Pages: 254-263
- DOI
  10.1093/carcin/bgab099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08284, KAKENHI-PROJECT-21K07892
[Journal Article] MicroRNA as a Biomarker in Gastroenterological Cancers.2022
- Author(s)
  Morishita A, Shirakami Y, Okumura T, Masaki T.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 23 Issue: 9 Pages: 4701-4701
- DOI
  10.3390/ijms23094701
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07892
[Journal Article] 短期間で急速に増大した食道癌肉腫の1例2022
- Author(s)
  水谷拓, 井深貴士, 三輪貴生, 宇野由佳里, 山下晃司, 高田淳, 久保田全哉, 境浩康, 白上洋平, 清水雅仁
- Journal Title
  
  Gastroenterological Endoscopy
  
  Volume: 64 Pages: 1106-1111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08284
[Journal Article] Micro-RNA Analysis of Pancreatic Cyst Fluid for Diagnosing Malignant Transformation of Intraductal Papillary Mucinous Neoplasm by Comparing Intraductal Papillary Mucinous Adenoma and Carcinoma2021
- Author(s)
  Shirakami Y, Iwashita T, Uemura S, Imai H, Murase K, Shimizu M.
- Journal Title
  
  J Clin Med
  
  Volume: 10 Issue: 11 Pages: 2249-2249
- DOI
  10.3390/jcm10112249
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08306, KAKENHI-PROJECT-21K07892
[Journal Article] Novel FXR agonist nelumal A suppresses colitis and inflammation-related colorectal carcinogenesis2021
- Author(s)
  Miyazaki Tsuneyuki、Shirakami Yohei、Mizutani Taku、Maruta Akinori、Ideta Takayasu、Kubota Masaya、Sakai Hiroyasu、Ibuka Takashi、Genovese Salvatore、Fiorito Serena、Taddeo Vito Alessandro、Epifano Francesco、Tanaka Takuji、Shimizu Masahito
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 492-492
- DOI
  10.1038/s41598-020-79916-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07968
[Journal Article] Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats2021
- Author(s)
  Shirakami Yohei、Nakanishi Takayuki、Ozawa Noritaka、Ideta Takayasu、Kochi Takahiro、Kubota Masaya、Sakai Hiroyasu、Ibuka Takashi、Tanaka Takuji、Shimizu Masahito
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 5 Pages: e0251942-e0251942
- DOI
  10.1371/journal.pone.0251942
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17396, KAKENHI-PROJECT-20K08284, KAKENHI-PROJECT-21K07892
[Journal Article] Higher Accumulation of Visceral Adipose Tissue Is an Independent Risk Factor for Hepatocellular Carcinoma among Viral Hepatitis Patients with Non-Cirrhotic Livers2021
- Author(s)
  Imai Kenji、Takai Koji、Miwa Takao、Maeda Toshihide、Hanai Tatsunori、Shirakami Yohei、Suetsugu Atsushi、Shimizu Masahito
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 23 Pages: 5980-5980
- DOI
  10.3390/cancers13235980
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07892
[Journal Article] Olmesartan-associated sprue-like enteropathy diagnosed by capsule endoscopy and double balloon endoscopy2021
- Author(s)
  Taguchi Daisuke、Ibuka Takashi、Arao Masamichi、Mizutani Taku、Ozawa Noritaka、Kubota Masaya、Shirakami Yohei、Shiraki Makoto、Araki Hiroshi、Shimizu Masahito
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 14 Issue: 6 Pages: 1649-1654
- DOI
  10.1007/s12328-021-01514-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17396, KAKENHI-PROJECT-20K08284, KAKENHI-PROJECT-21K07892
[Journal Article] Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas2021
- Author(s)
  Tomita Hiroyuki、Tanaka Kaori、Hirata Akihiro、Okada Hideshi、Imai Hisashi、Shirakami Yohei、Ohnishi Kotaro、Sugie Shigeyuki、Aoki Hitomi、Hatano Yuichiro、Noguchi Kei、Kanayama Tomohiro、Niwa Ayumi、Suzui Natsuko、Miyazaki Tatsuhiko、Tanaka Takuji、Akiyama Haruhiko、Shimizu Masahito、Yoshida Kazuhiro、Hara Akira
- Journal Title
  
  Cell Reports
  
  Volume: 34 Issue: 8 Pages: 108772-108772
- DOI
  10.1016/j.celrep.2021.108772
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03756, KAKENHI-PROJECT-18K07968
[Journal Article] 【老化と慢性炎症】肝臓における老化と慢性炎症2021
- Author(s)
  白上洋平、清水雅仁
- Journal Title
  
  別冊Bio Clinica: 慢性炎症と疾患
  
  Volume: 10 Pages: 63-67
- Data Source
  KAKENHI-PROJECT-21K07892
[Journal Article] Alpha-Glucosidase Inhibitor Voglibose Suppresses Azoxymethane-Induced Colonic Preneoplastic Lesions in Diabetic and Obese Mice.2020
- Author(s)
  Kato J, Shirakami Y, Mizutani T, Kubota M, Sakai H, Ibuka T, Shimizu M.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 21 Issue: 6 Pages: 2226-2226
- DOI
  10.3390/ijms21062226
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07968, KAKENHI-PROJECT-17K15936
[Journal Article] Acute cytomegalovirus infection in an immunocompetent patient with ulcerative colitis: A case report.2019
- Author(s)
  Maeda T, Sakai H, Ozawa N, Sugiyama T, Takada J, Kubota M, Ibuka T, Shirakami Y, Araki H, Shimizu M.
- Journal Title
  
  Exp Ther Med.
  
  Volume: 18 Pages: 2271-2277
- DOI
  10.3892/etm.2019.7823
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07968, KAKENHI-PROJECT-19K17396, KAKENHI-PROJECT-17K15936
[Journal Article] Diabetes Mellitus and Colon Carcinogenesis: Expectation for Inhibition of Colon Carcinogenesis by Oral Hypoglycemic Drugs.2019
- Author(s)
  Kato J, Shirakami Y, Shimizu M.
- Journal Title
  
  Gastrointest Disord.
  
  Volume: 1 Issue: 2 Pages: 273-289
- DOI
  10.3390/gidisord1020023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07968
[Journal Article] Meeting report of the 14th Japan Korea joint symposium on cancer and aging research: current status of translational research and approaches to precision medicine2019
- Author(s)
  Sueoka Eisaburo、Watanabe Tatsuro、Mashima Tetsuo、Shirakami Yohei、Komori Atsumasa、Matsuo Keitaro、Yoshikawa Hiroshi Y.、Cho Kyung A、Park Tae Jun、Seimiya Hiroyuki、Kim Eung-Gook、Suganuma Masami、Chung Junho
- Journal Title
  
  Journal of Cancer Research and Clinical Oncology
  
  Volume: 印刷中 Issue: 5 Pages: 1263-1271
- DOI
  10.1007/s00432-019-02887-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09850, KAKENHI-PROJECT-18K07337, KAKENHI-PROJECT-18K07968, KAKENHI-PUBLICLY-18H04633, KAKENHI-PROJECT-19H03523
[Journal Article] Suppressive effects of the sodium-glucose cotransporter 2 inhibitor tofogliflozin on colorectal tumorigenesis in diabetic and obese mice.2019
- Author(s)
  Kato J, Shirakami Y, Ohnishi M, Mizutani T, Kubota M, Sakai H, Ibuka T, Tanaka T, Shimizu M.
- Journal Title
  
  Oncol Rep.
  
  Volume: 42 Pages: 2797-2805
- DOI
  10.3892/or.2019.7357
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07968, KAKENHI-PROJECT-17K15936
[Journal Article] Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid2018
- Author(s)
  Qin XY, Suzuki H, Honda M, Okada H, Kaneko S, Inoue I, Ebisui E, Hashimoto K, Carninci P, Kanki K, Tatsukawa H, Ishibashi N, Masaki T, Matsuura T, Kagechika H, Toriguchi K, Hatano E, Shirakami Y, Shiota G, Shimizu M, Moriwaki H, Kojima S
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 115 Issue: 19 Pages: 4969-4974
- DOI
  10.1073/pnas.1802279115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09035, KAKENHI-PROJECT-16K19378, KAKENHI-PROJECT-18K06976, KAKENHI-PROJECT-18K15833, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K09353, KAKENHI-PROJECT-17K15933
[Journal Article] Prevention of Colorectal Cancer by Targeting Obesity-Related Disorders and Inflammation2017
- Author(s)
  Shirakami Yohei、Ohnishi Masaya、Sakai Hiroyasu、Tanaka Takuji、Shimizu Masahito
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 18 Issue: 5 Pages: 908-908
- DOI
  10.3390/ijms18050908
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15937, KAKENHI-PROJECT-16K19336
[Journal Article] Non-alcoholic steatohepatitis-related liver tumorigenesis is suppressed in mice lacking hepatic retinoid storage2017
- Author(s)
  Ideta, T. Shirakami, Y. Ohnishi, M. Maruta, A. Obara, K. Miyazaki, T. Kochi, T. Sakai, H. Tomita, H. Tanaka, T. Blaner, W. S. Shimizu, M.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 41 Pages: 70695-70706
- DOI
  10.18632/oncotarget.19978
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08735, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335, KAKENHI-PROJECT-17K15937, KAKENHI-PROJECT-16K19336
[Journal Article] Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic mice.2017
- Author(s)
  Obara K, Shirakami Y, Maruta A, Ideta T, Miyazaki T, Kochi T, Sakai H, Tanaka T, Seishima M, Shimizu M.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 35 Pages: 58353-58363
- DOI
  10.18632/oncotarget.16874
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335, KAKENHI-PROJECT-17K15937, KAKENHI-PROJECT-16K19336
[Journal Article] Preventative Effects of Pentoxifylline on the Development of Colonic Premalignant Lesions in Obese and Diabetic Mice2017
- Author(s)
  Fukuta K, Shirakami Y, Maruta A, Obara K, Iritani S, Nakamura N, Kochi T, Kubota M, Sakai H, Tanaka T, Shimizu M
- Journal Title
  
  Int J Mol Sci
  
  Volume: 18(2) Issue: 2 Pages: 413-413
- DOI
  10.3390/ijms18020413
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320, KAKENHI-PROJECT-16K19336, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335, KAKENHI-PROJECT-17K15936
[Journal Article] Preventive effects of astaxanthin on diethylnitrosamine-induced liver tumorigenesis in C57/BL/KsJ-db/db obese mice.2016
- Author(s)
  Ohno T, Shimizu M, Shirakami Y, Miyazaki T, Ideta T, Kochi T, Kubota M, Sakai H, Tanaka T, Moriwaki H.
- Journal Title
  
  Hepatol Res.
  
  Volume: 46(3) Issue: 3 Pages: 201-209
- DOI
  10.1111/hepr.12550
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335
[Journal Article] Metabolome Analyses Uncovered a Novel Inhibitory Effect of Acyclic Retinoid on Aberrant Lipogenesis in a Mouse Diethylnitrosamine-Induced Hepatic Tumorigenesis Model.2016
- Author(s)
  Qin XY, Tatsukawa H, Hitomi K, Shirakami Y, Ishibashi N, Shimizu M, Moriwaki H, Kojima S.
- Journal Title
  
  Cancer Prev Res
  
  Volume: 9 Pages: 205-214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19336
[Journal Article] Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents.2016
- Author(s)
  Sakai H, Shirakami Y, Shimizu M.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 22(1) Issue: 1 Pages: 394-406
- DOI
  10.3748/wjg.v22.i1.394
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19336
[Journal Article] Metabolome Analyses Uncovered a Novel Inhibitory Effect of Acyclic Retinoid on Aberrant Lipogenesis in a Mouse Diethylnitrosamine-Induced Hepatic Tumorigenesis Model.2016
- Author(s)
  Qin, X-Y., Tatsukawa, H., hitomi, K., Shirakami, Y., Ishibashi, N., Shimizu, M., Moriwaki, H., and *Kojima, S.
- Journal Title
  
  Cancer Prevention Res.
  
  Volume: 9(3) Issue: 3 Pages: 205-214
- DOI
  10.1158/1940-6207.capr-15-0326
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26102742, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-16K09352
[Journal Article] Cimetidine and Clobenpropit Attenuate Inflammation-Associated Colorectal Carcinogenesis in Male ICR Mice2016
- Author(s)
  Tanaka T, Kochi T, Shirakami Y, Mori T, Kurata A, Watanabe N, Moriwaki H, Shimizu M
- Journal Title
  
  Cancers
  
  Volume: 8 Issue: 2 Pages: 25-25
- DOI
  10.3390/cancers8020025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335, KAKENHI-PROJECT-16K19336
[Journal Article] Catechins and Its Role in Chronic Diseases.2016
- Author(s)
  Shirakami Y, Sakai H, Kochi T, Seishima M, Shimizu M.
- Journal Title
  
  Adv Exp Med Biol.
  
  Volume: 929 Pages: 67-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19336
[Journal Article] Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice.2016
- Author(s)
  Miyazaki T, Shirakami Y, Kubota M, Ideta T, Kochi T, Sakai H, Tanaka T, Moriwaki H, Shimizu M.
- Journal Title
  
  Oncotarget.
  
  Volume: 7 Pages: 10448-10458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19336
[Journal Article] Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice.2016
- Author(s)
  Miyazaki T, Shirakami Y, Kubota M, Ideta T, Kochi T, Sakai H, Tanaka T, Moriwaki H, Shimizu M.
- Journal Title
  
  Oncotarget
  
  Volume: - Issue: 9 Pages: 10448-10458
- DOI
  10.18632/oncotarget.7249
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335
[Journal Article] 新規肝線維化マーカー「Mac-2 binding protein 糖鎖修飾異性体（M2BPGi）」のＣ型肝炎に対するペグインターフェロン・リバビリン併用療法による変化2015
- Author(s)
  石田秀和，末次　淳，中村真大，田内里奈，中山純里，片野由里子，古田伸行，白上洋平，伊藤弘康，清島　満．
- Journal Title
  
  臨床病理
  
  Volume: 63 Pages: 901-906
- Data Source
  KAKENHI-PROJECT-26860498
[Journal Article] Retinoid roles in blocking hepatocellular carcinoma.2015
- Author(s)
  Shirakami Y，Sakai H, Shimizu M.
- Journal Title
  
  Hepatobilliary Surg Nutr
  
  Volume: 4 Pages: 222-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860498
[Journal Article] Pentoxifylline prevents non-alcoholic steatohepatitis-related liver pre-neoplasms by inhibiting hepatic inflammation and lipogenesis.2015
- Author(s)
  Shirakami Y, Shimizu M, Kubota M, Ohno T, Kochi T, Nakamura N, Sumi T, Tanaka T, Moriwaki H, Seishima M.
- Journal Title
  
  Eur J Cancer Prev
  
  Volume: 25 Issue: 3 Pages: 206-215
- DOI
  10.1097/cej.0000000000000172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K19335
[Journal Article] Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice.2015
- Author(s)
  Nakamura N, Hara T, Shimizu M, Mabuchi R, Nagano J, Ohno T, Kochi T, Kubota M, Shirakami Y, Goto N, Ito H, Saito K, Tanaka T, Moriwaki H, Tsurumi H.
- Journal Title
  
  Int J Hematol
  
  Volume: 102 Issue: 3 Pages: 327-334
- DOI
  10.1007/s12185-015-1835-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860498
[Journal Article] Utility of Apc-mutant rats with a colitis-associated colon carcinogenesis model for chemoprevention studies.2015
- Author(s)
  Kochi T, Shimizu M, Shirakami Y, Yoshimi K, Kuramoto T, Tanaka T, Moriwaki H.
- Journal Title
  
  Eur J Cancer Prev
  
  Volume: 24 Issue: 3 Pages: 180-187
- DOI
  10.1097/cej.0000000000000063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860498
[Journal Article] Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice.2015
- Author(s)
  Shimizu M, Ohno T, Shirakami Y, Baba A, Kochi T, Kubota M, Tsurumi H, Tanaka T, Moriwaki H.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 4 Pages: e0124081-e0124081
- DOI
  10.1371/journal.pone.0124081
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529, KAKENHI-PROJECT-26860498
[Journal Article] Chemopreventive Potential of Green Tea Catechins in Hepatocellular Carcinoma.2015
- Author(s)
  Shimizu M, Shirakami Y, Sakai H, Kubota M, Kochi T, Ideta T, Miyazaki T, Moriwaki H.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 16 Pages: 6124-6139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860498
[Journal Article] Chemopreventive potential of green tea catechins in hepatocellular carcinoma.2015
- Author(s)
  Shimizu M, Shirakami Y, Sakai H, Kubota M, Kochi T, Ideta T, Miyazaki T, Moriwaki H.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 16(3) Issue: 3 Pages: 6124-6139
- DOI
  10.3390/ijms16036124
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320, KAKENHI-PROJECT-25860529, KAKENHI-PROJECT-26860498
[Journal Article] The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Attenuates Hepatic Lipogenesis via AMPK Activation in Non-Alcoholic Fatty Liver Disease Model Mice.2015
- Author(s)
  Ideta T, Shirakami Y, Miyazaki T, Kochi T, Sakai H, Moriwaki H, Shimizu M.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 16(12) Issue: 12 Pages: 29207-29218
- DOI
  10.3390/ijms161226156
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19320, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-26860498
[Journal Article] Combination of Bevacizumab and Acyclic Retinoid Inhibits the Growth of Hepatocellular Carcinoma Xenografts2014
- Author(s)
  Kubota M, Shimizu M, Baba A, Ohno T, Kochi T, Shirakami Y, Moriwaki H.
- Journal Title
  
  Journal of Nutritional Science and Vitaminology
  
  Volume: 60 Issue: 5 Pages: 357-362
- DOI
  10.3177/jnsv.60.357
- NAID
  130004773635
- ISSN
  0301-4800, 1881-7742
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-25860529, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-221S0001
[Journal Article] Inhibitory effects of astaxanthin on azoxymethane-induced colonic preneoplastic lesions in C57/BL/KsJ- db/db mice. BMC Gastroenterol.2014
- Author(s)
  Kochi T, Shimizu M, Sumi T, Kubota M, Shirakami Y, Tanaka T, Moriwaki H.
- Journal Title
  
  BMC Gastroenterol
  
  Volume: 14 Pages: 212-212
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26860498
[Journal Article] Preventive effects of captopril, an angiotensin-converting enzyme inhibitor, on the development of azoxymethane-induced colonic preneoplastic lesions in diabetic and hypertensive rats.2014
- Author(s)
  Kochi T, Shimizu M, Ohno T, Baba A, Sumi T, Kubota M, Shirakami Y, Tsurumi H, Tanaka T, Moriwaki H.
- Journal Title
  
  Oncol Lett
  
  Volume: 8 Pages: 223-229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860498
[Journal Article] Pharmaceutical and nutraceutical approaches for preventing liver carcinogenesis: chemoprevention of hepatocellular carcinoma using acyclic retinoid and branched-chain amino acids.2014
- Author(s)
  Shimizu M, Shirakami Y, Hanai T, Imai K, Suetsugu A, Takai K, Shiraki M, Moriwaki H.
- Journal Title
  
  Mol Nutr Food Res.
  
  Volume: 58 Issue: 1 Pages: 124-135
- DOI
  10.1002/mnfr.201300538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890081, KAKENHI-PROJECT-25460987, KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-26460997, KAKENHI-PROJECT-26860498, KAKENHI-PROJECT-221S0001
[Journal Article] A novel aromatic mutagen, 5-amino-6-hydroxy-8H-benzo [6,7] azepino [5,4,3-de] quinolin-7-one (ABAQ), induces colonic preneoplastic lesions in mice.2014
- Author(s)
  Kochi T, Shimizu M, Totsuka Y, Shirakami Y, Nakanishi T, Watanabe T, Tanaka T, Nakagama H, Wakabayashi K, Moriwaki H.
- Journal Title
  
  Toxicology Rep
  
  Volume: 1 Pages: 69-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860498
[Journal Article] Chemoprevention of colorectal cancer by targeting obesity-related metabolic abnormalities.2014
- Author(s)
  Shirakami Y, Shimizu M, Kubota M, Araki H, Tanaka T, Moriwaki H, Seishima M.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 20 Pages: 8939-8946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860498
[Journal Article] 哺乳類ラパマイシン標的たんぱく質経路2014
- Author(s)
  白上洋平，清水雅仁．
- Journal Title
  
  栄養―評価と治療
  
  Volume: 31 Pages: 230-233
- Data Source
  KAKENHI-PROJECT-26860498
[Journal Article] Apc-mutant Kyoto Apc Delta (KAD) rats are susceptible to 4-NQO-induced tongue carcinogenesis.2014
- Author(s)
  Tanaka T, Shimizu M, Kochi T, Shirakami Y, Mori T, Watanabe N, Naiki T, Moriwaki H, Yoshimi K, Serikawa T, Kuramoto T.
- Journal Title
  
  Cancers
  
  Volume: 6 Pages: 1522-1539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860498
[Journal Article] A newly synthesized compound, 4'-geranyloxyferulic acid-N(omega)-nitro-l-arginine methyl ester suppresses inflammation-associated colorectal carcinogenesis in male mice.2014
- Author(s)
  Shimizu M, Kochi T, Shirakami Y, Genovese S, Epifano F, Fiorito S, Mori T, Tanaka T, Moriwaki H.
- Journal Title
  
  Int J Cancer
  
  Volume: 135 Issue: 4 Pages: 774-784
- DOI
  10.1002/ijc.28718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460988, KAKENHI-PROJECT-26860498
[Presentation] A Novel Model of Intrahepatic Cholangiocarcinoma Using Obese Mice and Carcinogen2024
- Author(s)
  Maeda T, Shirakami Y, Taguchi D, Kubota M, Sakai H, Shimizu M
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL) 2024 Kyoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07892
[Presentation] 腹部超音波検査を契機に診断された肝外門脈閉塞症の一例2023
- Author(s)
  関根綾子、白上洋平、高田彩永、中山純里、高井光治、菊地良介、渡邉崇量、大倉宏之
- Organizer
  日本超音波学会第44回中部地方会学術集会
- Data Source
  KAKENHI-PROJECT-21K07892
[Presentation] クローン病モデルマウスを用いた腸管免疫制御における Retinoid X Receptor-αの役割に関する研究2023
- Author(s)
  境浩康、田口大輔、前田俊英、白上洋平、清水雅仁
- Organizer
  日本レチノイド研究会第34回学術集会
- Data Source
  KAKENHI-PROJECT-21K07892
[Presentation] High-fat Diet Promotes Hepatic Fibrosis and Tumorigenesis in a Rat Cirrhosis Model2023
- Author(s)
  Daisuke Taguchi, Yohei Shirakami, Toshihide Maeda, Hiroyasu Sakai, Masahito Shimizu
- Organizer
  The Asian Pacific Association for the Study of the Liver (APASL) Oncology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07892
[Presentation] Steatotic and fibrotic liver and related conditions in senescence-accelerated mice2023
- Author(s)
  Shirakami Y, Sakai H, Shimizu M.
- Organizer
  The 3rd JSH International Liver Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07892
[Presentation] 大腸粘膜内癌を合併したCronkhite-Canada症候群の1例2022
- Author(s)
  雄山裕亮, 井深貴士, 小林立樹, 岩佐太誠, 亀井真琴, 小泉悠, 大谷毅一, 田口大輔, 山下晃司, 小島健太郎, 高田淳, 久保田全哉, 境浩康, 白上洋平, 末次淳, 清水雅仁
- Organizer
  第65回日本消化器内視鏡学会東海支部例会
- Data Source
  KAKENHI-PROJECT-20K08284
[Presentation] Workshop 21「Molecular Mechanisms of Liver Fibrosis」Steatotic and fibrotic liver and related conditions in senescence-accelerated mice.2022
- Author(s)
  Shirakami Y, Shimizu M.
- Organizer
  APASL Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07892
[Presentation] シンポジウム21「個別化予防医療・先制医療」 Prevention of hepatocellular carcinoma by targeting cancer stem cell with acyclic retinoid.2022
- Author(s)
  Shirakami Y, Qin XY, Sakai H, Shimizu M.
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07892
[Presentation] 肥満マウスを用いた肝内胆管発癌モデル2022
- Author(s)
  白上洋平、加藤潤一、前田俊英、久保田全哉、境　浩康、富田弘之、田中卓二、清水雅仁
- Organizer
  第12回肥満と消化器疾患研究会
- Data Source
  KAKENHI-PROJECT-21K07892
[Presentation] 膵貯蔵レチノイドと膵線維化2022
- Author(s)
  白上洋平、境　浩康、清水雅仁
- Organizer
  第373回脂溶性ビタミン総合研究委員会
- Data Source
  KAKENHI-PROJECT-21K07892
[Presentation] TNBS誘発マウス大腸炎におけるRetinoid X Receptor-αの役割に関する研究2022
- Author(s)
  白上洋平、境　浩康、田口大輔、前田俊英、清水雅仁
- Organizer
  日本レチノイド研究会第33回学術集会
- Data Source
  KAKENHI-PROJECT-21K07892
[Presentation] ワークショップ３「加齢と臓器連関－肝臓を中心に（胆汁酸、Microbiome含む）」老化マウスにおける骨格筋萎縮は脂肪肝由来のTNF-alphaにより増悪する2022
- Author(s)
  白上洋平、清水雅仁
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K07892
[Presentation] 老化促進マウスSAMにおけるサルコペニア　肝筋相関に基づいた検討2021
- Author(s)
  清水雅仁, 白上洋平
- Organizer
  第21回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-21K07892
[Presentation] Antidiabetic agents for cancer prevention2018
- Author(s)
  Yohei Shirakami, Junichi Kato, Taku Mizutani, Takahiro Kochi, Hiroyasu Sakai, Masahito Shimizu
- Organizer
  The 14th Japan-Korea Joint Symposium on Cancer and Ageing Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07968
[Presentation] Non-alcoholic steatohepatitis-related hepatocarcinogenesis is suppressed in mice lacking hepatic retinoid storage2018
- Author(s)
  Yohei Shirakami, Takayasu Ideta, Hiroyasu Sakai, Takuji Tanaka, Masahito Shimizu, Mitsuru Seishima
- Organizer
  Asian Pacific Association for the Study of the Liver Single Topic Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07968
[Presentation] The roles of acyclic retinoid in blocking hepatocellular carcinoma.2018
- Author(s)
  Shirakami Y
- Organizer
  JSPS拠点形成プログラムシンポジウム「難治疾患に対する分子標的薬創製のための国際共同研究拠点の構築」
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] 核内受容体とそのリガンドの医学2018
- Author(s)
  白上洋平、境　浩康、清水雅仁
- Organizer
  第29回日本レチノイド研究会学術集会
- Data Source
  KAKENHI-PROJECT-18K07968
[Presentation] ミニシンポジウム「核内受容体とそのリガンドの化学・生物学・医学」核内受容体とそのリガンドの医学2018
- Author(s)
  白上洋平　　境　浩康　　清水雅仁
- Organizer
  日本レチノイド研究会第29回学術集会
- Data Source
  KAKENHI-PROJECT-16K09352
[Presentation] Effects of fatty liver on development of intrahepatic cholangiocarcinoma2018
- Author(s)
  白上洋平、加藤潤一、水谷　拓、河内隆宏、境　浩康、富田弘之、田中卓二、清水雅仁
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07968
[Presentation] パネルディスカッション「生活習慣病・メタボリックシンドロームからの消化器疾患」酸化ストレスの制御による肥満関連大腸発癌の抑制2017
- Author(s)
  白上洋平、清水雅仁、清島　満
- Organizer
  第103回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] 糖尿病治療薬による肥満に関連する肝発癌の抑制2017
- Author(s)
  白上洋平、小原功輝、境　浩康、田中卓二、清水雅仁、清島　満
- Organizer
  がん予防学術大会2017（第24回日本がん予防学会総会）
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] レチノイド受容体遺伝子改変マウスにおける糖・脂質代謝異常2017
- Author(s)
  白上洋平、境　浩康、清水雅仁、清島　満
- Organizer
  日本レチノイド研究会第28回学術集会
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on liver tumorigenesis in obese mice.2017
- Author(s)
  Shirakami Y, Obara K, Tanaka T, Shimizu M, Seishima M.
- Organizer
  Asian Pacific Association for the Study of the Liver (APASL) Single Topic Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] 肥満に関連した肝疾患に対する糖尿病治療薬の作用2017
- Author(s)
  白上洋平、清水雅仁、清島　満
- Organizer
  第42回日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] 糖尿病治療薬SGLT-2阻害薬が肝脂肪化および肝発癌に及ぼす影響2017
- Author(s)
  白上洋平、小原功輝、境　浩康、田中卓二、清水雅仁、清島　満
- Organizer
  第24回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] The sodium glucose cotransporter 2 inhibitor tofogliflozin inhibits obesity-related liver tumorigenesis.2017
- Author(s)
  白上洋平、小原功輝、大西雅也、境　浩康、田中卓二、清水雅仁、清島　満
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on liver tumorigenesis in obese and diabetic mice.2017
- Author(s)
  Shirakami Y, Obara K, Ohnishi M, Ideta T, Sakai H, Tanaka T, Shimizu M, Seishima M.
- Organizer
  108th American Association for Cancer Research (AACR) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] パネルディスカッション「生活習慣病・メタボリックシンドロームからの消化器疾患」酸化ストレスの制御による肥満関連大腸発癌の抑制2017
- Author(s)
  白上洋平　　清水雅仁　　清島　満
- Organizer
  第103回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K09352
[Presentation] 糖尿病治療薬SGLT-2阻害薬による肥満関連肝発癌の抑制2017
- Author(s)
  白上洋平、小原功輝、河内隆宏、境　浩康、田中卓二、清水雅仁、清島　満
- Organizer
  第49回日本臨床分子形態学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] NASHおよび関連する肝発癌にSGLT-2阻害薬が及ぼす影響2017
- Author(s)
  白上洋平、清水雅仁、清島　満
- Organizer
  JDDW2017（第41回日本肝臓学会大会）
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] SGLT2阻害薬の脂肪肝および肝発癌に対する効果2017
- Author(s)
  白上洋平、小原功輝、田中卓二、清水雅仁、清島　満
- Organizer
  第7回肥満と消化器疾患研究会
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] ワークショップ「消化器疾患と代謝異常の関わり」糖尿病治療薬を用いた肥満に関連する肝疾患の抑制2016
- Author(s)
  白上洋平, 清水雅仁, 清島　満
- Organizer
  JDDW2016（第58回日本消化器病学会大会）
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] ワークショップ「消化器疾患と代謝異常の関わり」糖尿病治療薬を用いた肥満に関連する肝疾患の抑制2016
- Author(s)
  白上洋平, 清水雅仁, 清島　満
- Organizer
  JDDW2016（第58回日本消化器病学会大会）
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-16K09352
[Presentation] FXR agonistによる大腸炎および大腸発癌の抑制2016
- Author(s)
  白上洋平, 宮崎恒起, 出田貴康, 境　浩康, 渡部直樹, 田中卓二, 清水雅仁, 清島　満
- Organizer
  第23回日本がん予防学会総会（がん予防学術大会2016）
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] Preventive effects of pentoxifylline on hepatic tumorigenesis in a novel mouse model of NASH-related liver cancer.2016
- Author(s)
  Shirakami Y, Sakai H, Ideta T, Takuji Tanaka, Shimizu M, Seishima M.
- Organizer
  107th American Association for Cancer Research (AACR) Annual Meeting
- Place of Presentation
  New Orleans, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] Non-alcoholic steatohepatitis-related liver tumorigenesis is suppressed in mice lacking hepatic retinoid store.2016
- Author(s)
  Shirakami Y, Ideta T, Sakai H, Tanaka T, Blaner WS, Shimizu M, Seishima M.
- Organizer
  FASEB Science Research Conference (3rd International Conference on Retinoids)
- Place of Presentation
  West Palm Beach, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] NASH-related liver tumorigenesis is suppressed in mice lacking hepatic retinoid storage.2016
- Author(s)
  Shirakami Y, Ideta T, Sakai H, Tanaka T, Blaner WS, Shimizu M, Seishima M.
- Organizer
  The 12th JSH (Japan Society of Hepatology) Single Topic Conference
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] 肝レチノイド貯蔵欠如マウスにおいて非アルコール性脂肪肝炎関連肝発癌は抑制される2016
- Author(s)
  白上洋平, 出田貴康, 大西雅也, 境　浩康, 田中卓二, 清水雅仁, 清島　満
- Organizer
  日本レチノイド研究会第27回学術集会
- Place of Presentation
  町田
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] Non-alcoholic steatohepatitis-related liver tumorigenesis is suppressed in mice lacking hepatic retinoid storage.2016
- Author(s)
  白上洋平, 出田貴康, 境　浩康, 田中卓二, 清水雅仁, 清島　満
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-16K19336
[Presentation] 非環式レチノイドによる抗HBV作用2015
- Author(s)
  白上洋平　　清水雅仁
- Organizer
  日本医療研究開発機構（肝炎等克服実用化研究事業）合同班会議
- Place of Presentation
  東京
- Year and Date
  2015-07-11
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] 新規芳香族変異源物質5-amino-6-hydroxy-8H-benzo[6,7]azepino[5,4,3-de]quinolin-7-one (ABAQ)の大腸発癌実験における有用性について2015
- Author(s)
  河内隆宏、白上洋平、清水雅仁
- Organizer
  JDDW 2015（第57回日本消化器病学会大会）
- Place of Presentation
  東京
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] NAFLDモデルマウスにおけるDPP4阻害薬テネリグリプチンの影響2015
- Author(s)
  出田貴康、白上洋平、宮崎恒起、河内隆宏、境　浩康、清水雅仁
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  熊本
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] Effects of a synthetic retinoid on hepatitis B virus.2015
- Author(s)
  Shirakami Y, Maruta A, Obara K, Ideta T, Miyazaki T, Sakai H, Shimizu M, Seishima M.
- Organizer
  The 3rd International Conference on Retinoids
- Place of Presentation
  岐阜
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] The role of the phosphorylated RXR-alpha on diethylnitrosamine-induced liver tumorigenesis in mice.2015
- Author(s)
  Sakai H, Yamada Y, Shirakami Y, Hara A, and Shimizu M.
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] 肥満関連肝発癌におけるアスタキサンチンの抑制効果2015
- Author(s)
  出田貴康、大野智彦、宮崎恒起、河内隆宏、白上洋平、清水雅仁
- Organizer
  がん予防学術大会2015（第22回日本がん予防学会総会）
- Place of Presentation
  埼玉
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] 大腸発癌モデルにおける選択的EP4受容体拮抗薬RQ-00015986の作用2015
- Author(s)
  白上洋平、出田貴康、宮崎恒起、河内隆宏、境　浩康、清水雅仁、清島　満
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] NAFLD/NASHモデルマウスにおいてDPP4阻害薬テネリグリプチンは肝脂肪化を抑制する2015
- Author(s)
  出田貴康、白上洋平、宮崎恒起、河内隆宏、境　浩康、清水雅仁
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台
- Year and Date
  2015-04-25
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] 非アルコール性脂肪肝炎モデルにおいてDPP4阻害薬テネグリプチンは肝脂肪化を抑制する2015
- Author(s)
  白上洋平、岩佐将充、伊藤弘康、清島　満
- Organizer
  第62回日本臨床検査医学会学術集会
- Place of Presentation
  岐阜
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] Prevention of lifestyle disease-related gastroenterological carcinogenesis through regulation of oxidative stress. (English Session2015
- Author(s)
  Kochi T, Shirakami Y, Shimizu M.
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] The role of the phosphorylated RXR-alpha on cellular proliferation and liver tumorigenesis.2015
- Author(s)
  Sakai H, Shirakami Y, Shimizu M, and Moriwaki H.
- Organizer
  106th American Association for Cancer Research (AACR) Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] ラット大腸発癌モデルにおける選択的EP4受容体拮抗薬の作用2015
- Author(s)
  白上洋平、中西孝之、河内隆宏、出田貴康、宮崎恒起、清水雅仁、清島　満
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] The role of the phosphorylated RXR-alpha on diethylnitrosamine-induced liver tumorigenesis in mice.2015
- Author(s)
  Sakai H, Yamada Y, Shirakami Y, Hara A, Shimizu M.
- Organizer
  The 3rd International Conference on Retinoids
- Place of Presentation
  岐阜
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] ラット大腸発癌モデルにおけるペントキシフィリンの発癌抑制効果2015
- Author(s)
  白上洋平、出田貴康、宮崎恒起、河内隆宏、境　浩康、清水雅仁、清島　満
- Organizer
  がん予防学術大会2015（第22回日本がん予防学会総会）
- Place of Presentation
  埼玉
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] DPP4阻害薬テネリグリプチンのNAFLDモデルマウスにおける効果2015
- Author(s)
  出田貴康　　白上洋平　　宮崎恒起　　河内隆宏　　境　浩康　　清水雅仁
- Organizer
  JDDW 2015（第19回日本肝臓学会大会）
- Place of Presentation
  東京
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] “Effect of FXR agonist Nelumal A on colitis and colorectal carcinogenesis in mice.”2015
- Author(s)
  Tsuneyuki Miyazaki, Noritaka Ozawa, Takahiro Kochi, Naoki Watanabe, Hiroyasu Sakai, Yohei Shirakami, Takuji Tanaka, Masahito Shimizu, Hisataka Moriwaki
- Organizer
  The 3rd International Conference on Retinoids
- Place of Presentation
  岐阜
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] アスタキサンチンによる肥満関連肝・大腸発癌の抑制効果2015
- Author(s)
  河内隆宏、白上洋平、出田貴康、宮崎恒起、清水雅仁
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] Preventive effect of a prostaglandin E receptor EP4 antagonist on rat colon tumorigenesis.2015
- Author(s)
  Shirakami Y, Sakai H, Kochi T, Ideta T, Miyazaki T, Shimizu M, Seishima M.
- Organizer
  106th American Association for Cancer Research (AACR) Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice.2015
- Author(s)
  Ideta T, Terakura D, Shimizu M, Miyazaki T, Kochi T, Sakai H, Shirakami Y, Tanaka T, Moriwaki H.
- Organizer
  106th American Association for Cancer Research (AACR) Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] 酸化ストレスの制御を介した生活習慣病関連消化器発癌の抑制2015
- Author(s)
  清水雅仁　　河内隆宏　　白上洋平
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice.2014
- Author(s)
  Ideta T, Terakura D, Masahito S, Miyazaki T, Iwasa J, Baba A, Kochi T, Ohno T, Kubota M, Sakai H, Shirakami Y, Shiraki M, Takai K, Turumi H, Tanaka T, Moriwaki H.
- Organizer
  The 12th Japan-Korea Joint Symposium on Cancer and Ageing Research
- Place of Presentation
  埼玉
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] B型肝炎ウイルスに対する非環式レチノイドの効果2014
- Author(s)
  白上洋平　　出田貴康　　宮崎恒起　　境　浩康　　清水雅仁
- Organizer
  日本レチノイド研究会第25回学術集会
- Place of Presentation
  秋田
- Year and Date
  2014-10-12
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] Chemopreventive effects of pentoxifylline on inflammation-related rat colon tumorigenesis and endoscopic observation.2014
- Author(s)
  Shirakami Y, Shimizu M, Kochi T, Moriwaki H, Seishima M.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] 大腸発癌モデルにおけるペントキシフィリンの発癌抑制効果2014
- Author(s)
  白上洋平　　清水雅仁　　河内隆宏　　森脇久隆　　清島　満
- Organizer
  JDDW2014（第56回日本消化器病学会大会）
- Place of Presentation
  神戸
- Year and Date
  2014-10-23
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] The role of the phosphorylated RXR-alpha on cellular proliferation and liver tumorigenesis.2014
- Author(s)
  Sakai H, Shirakami Y, Shimizu M, Moriwaki H.
- Organizer
  The 2nd International Conference on Retinoids (FASEB Meeting 2014)
- Place of Presentation
  Itasca, Illinois, USA
- Year and Date
  2014-06-02
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] Effects of histamine receptor antagonists on inflammation-associated colon carcinogenesis in mice.2014
- Author(s)
  Tanaka T, Kochi T, Shirakami Y, Watanabe N, Moriwaki H, Shimizu M.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] Wip1 prevents cellular senescence at physiological oxygen levels by regulating DNA damage response (DDR) during S-phase.2014
- Author(s)
  Sakai H, Shirakami Y, Shimizu M, Moriwaki H.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] アスタキサンチンによる肥満関連発癌の抑制効果2014
- Author(s)
  出田貴康　　大野智彦　　宮崎恒起　　河内隆宏　　境　浩康白上洋平　　清水雅仁　　森脇久隆
- Organizer
  日本レチノイド研究会第25回学術集会
- Place of Presentation
  秋田
- Year and Date
  2014-10-12
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] Wild-type p53-inducible phosphatase 1 (Wip1) forestalls cellular senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication.2014
- Author(s)
  Sakai H, Shirakami Y, Shimizu M, Moriwaki H.
- Organizer
  The 12th Japan-Korea Joint Symposium on Cancer and Ageing Research
- Place of Presentation
  埼玉
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] Sodium alginate prevents the progression of non-alcoholic steatohepatitis and liver carcinogenesis in mice.2014
- Author(s)
  Miyazaki T, Kubota M, Kochi T, Shirakami Y, Shimizu M, Tanaka T, Moriwaki H.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] 肥満関連および炎症性大腸発癌モデルにおけるペントキシフィリンの発癌抑制作用2014
- Author(s)
  白上洋平，清水雅仁，森脇久隆，清島　満
- Organizer
  第100回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2014-04-25
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] Impact of hypertension on colorectal carcinogenesis and prevention of colonic preneoplastic lesions by captopril.2014
- Author(s)
  Miyazaki T, Kochi T, Shimizu M, Ohno T, Baba A, Sumi T, Kubota M, Shirakami Y, Tsurumi H, Tanaka T, Moriwaki H.
- Organizer
  The 12th Japan-Korea Joint Symposium on Cancer and Ageing Research
- Place of Presentation
  埼玉
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] A novel mouse model of NASH-related liver cancer and preventive effects of pentoxifylline on liver tumorigenesis.2014
- Author(s)
  Shirakami Y, Shimizu M, Sakai H, Moriwaki H, Seishima M.
- Organizer
  The 12th Japan-Korea Joint Symposium on Cancer and Ageing Research
- Place of Presentation
  埼玉
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] A synthetic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic db/db mice.2014
- Author(s)
  Shirakami Y, Shimizu M, Sakai H, Moriwaki H.
- Organizer
  The 2nd International Conference on Retinoids (FASEB Meeting 2014)
- Place of Presentation
  Itasca, Illinois, USA
- Year and Date
  2014-06-03
- Data Source
  KAKENHI-PROJECT-26860498
[Presentation] Targeting obesity-related metabolic abnormalities for chemoprevention of hepatocellular carcinoma.2014
- Author(s)
  Shimizu M, Shirakami Y, Sakai H, Kubota M, Kochi T, Tanaka T, Moriwaki H.
- Organizer
  97.第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26860498

1. Shimizu Masahito (90402198)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. SHIRAKI MAKOTO (60402195)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 華井竜徳 (40585494)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. Ito Hiroyasu (80373075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SEISHIMA Mitsuru (10171315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Kubota Masaya (90542407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 出田貴康 (90610379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 三輪貴生 (80939570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MASAKI Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
10. 境浩康

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
11. Qin XianYang

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 岩下拓司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 末岡尚子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 末岡榮三朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 森脇久隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
16. 小嶋聡一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 小澤範高

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 宮崎龍彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 末次淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 富田弘之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 岡田英志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIRAKAMI Yohei 白上 洋平

Research Projects

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Co-Researchers

レチノイドシグナル阻害による新規マウス胆管癌モデルの開発と治療薬の探索Principal Investigator

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診療ガイドラインの検証と老化モデルの解析に基づく高齢肝硬変患者の包括的治療戦略

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Novel mouse models of cholangiocarcinoma focusing on retinoid signaling and fatty liverPrincipal Investigator

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Molecular abnormalities and DNA methylation in obesity-related colorectal carcinogenesis

Principal Investigator

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Liver failure and liver carcinogenesis prevention by liver-skeletal muscle correlation control

Principal Investigator

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Comprehensive treatment strategy for chronic liver disease patients based on body composition analysis

Principal Investigator

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Establishment of new mouse models for investigating the effect of fatty liver on intrahepatic bile duct cancer developmentPrincipal Investigator

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Development of the innovative chemopreventive strategy for metabolic syndrome-related liver carcinogenesis by targeting multiple organ network

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Elucidation of the pathological condition of non-alcoholic fatty liver disease regarding retinoid receptor signalingPrincipal Investigator

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Relationship between non-alcoholic fatty liver disease and hepatic retinoid signalingPrincipal Investigator

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Inhibition of iNOS activity enhances the anti-tumor effects of alpha-galactosylceramide in cancer model

Principal Investigator

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[Book] 臨床検査ガイド2015年改訂版2015

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[Book] 臨床検査ガイド 2015年改訂版2015

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Publisher

Data Source

SHIRAKAMI Yohei 白上洋平

[Book] 臨床検査ガイド　2015年改訂版2015