Miyoshi Hirotugu 三好寛二

… Alternative Names

Miyoshi Hirotsugu 三好寛二

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Researcher Number	50645364
Other IDs
Affiliation (Current)	2025: 広島大学, 病院(医), 講師
Affiliation (based on the past Project Information) *help	2025: 広島大学, 病院(医), 講師 2022 – 2023: 広島大学, 病院(医), 講師 2021: 広島大学, 医系科学研究科(医), 助教
Review Section/Research Field	Principal Investigator Basic Section 55050:Anesthesiology-related Except Principal Investigator Basic Section 55050:Anesthesiology-related
Keywords	Principal Investigator 熱ストレス / リアノジン受容体 / うつ熱 / TRPV1受容体 / カプサイシン受容体 / 遺伝子変異 / 遺伝子解析 / TRPV1 / 悪性高熱症 Except Principal Investigator 悪性高熱症 … More / 吸入麻酔薬 / CACNA1S / RYR1 / ノックインマウス / 虚血再灌流障害 / 細胞膜マイクロドメイン / 加齢 / 遺伝子 / 骨格筋 / カルシウム / 遺伝子パネル検査 / NGS / TRPV1 / STAC3 / 遺伝子解析 / 原因遺伝子 / リアノジン受容体 / 遺伝子変異 / ジヒドロピリジン受容体 / 脂肪酸 / グルコース / エネルギー代謝 / 心肥大 / マイクロドメイン / カベオラ・カベオリン / ミトコンドリア / 心筋保護作用 Less

全ゲノムシークエンスによる悪性高熱症の新規原因遺伝子変異の検索とその機能解析Principal Investigator
- Principal Investigator
  
  三好寛二
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Hiroshima University
Search for novel variants and their functional analysis by malignant hyperthermia-associated gene panel test
- Principal Investigator
  
  向田圭子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Hiroshima University
Investigation of the effect of aging on the development of malignant hyperthermia in RYR1 knock-in mouse.
- Principal Investigator
  
  大月幸子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Hiroshima University
新規原因遺伝子に対する悪性高熱症の機能解析実験系の確立
- Principal Investigator
  
  渡辺知幸
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Hiroshima University
悪性高熱症の原因遺伝子としてのSTAC3・TRPV1の関与の探索
- Principal Investigator
  
  神崎理英子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Hiroshima University
Elucidation of TRPV1 channel function in the mechanism of malignant hyperthermiaPrincipal Investigator
- Principal Investigator
  
  Miyoshi Hirotsugu
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Hiroshima University
Effects of microdomains and anesthetics on energy metabolism in cardiac hypertrophy.
- Principal Investigator
  
  NARASAKI Soshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Hiroshima University
Cardiac protection by volatile anesthetic -Role of caveolae and mitochondrial regulation-
- Principal Investigator
  
  TSUTSUMI Yasuo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Hiroshima University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Rapid dantrolene administration with body temperature monitoring is associated with decreased mortality in Japanese malignant hyperthermia events.2023
- Author(s)
  Toyota Y, Kondo T, Shorin D, Sumii A, Kido K, Watanabe T, Otsuki S, Kanzaki R, Miyoshi H, Yasuda T, Horikawa YT, Mukaida K, Tsutsumi YM.
- Journal Title
  
  BioMed Res Int
  
  Volume: 2023 Issue: 1 Pages: 8340209-8340209
- DOI
  10.1155/2023/8340209
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09047, KAKENHI-PROJECT-22K09070, KAKENHI-PROJECT-22K09095
[Journal Article] Effects of Remimazolam on Intracellular Calcium Dynamics in Myotubes Derived from Patients with Malignant Hyperthermia and Functional Analysis of Type 1 Ryanodine Receptor Gene Variants2023
- Author(s)
  Miyoshi Hirotsugu、Otsuki Sachiko、Mukaida Keiko、Kido Kenshiro、Sumii Ayako、Ikeda Tsuyoshi、Noda Yuko、Yasuda Toshimichi、Narasaki Soshi、Kato Takahiro、Kamiya Satoshi、Horikawa Yousuke T.、Tsutsumi Yasuo M.
- Journal Title
  
  Genes
  
  Volume: 14 Issue: 11 Pages: 2009-2009
- DOI
  10.3390/genes14112009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09047, KAKENHI-PROJECT-23K08332, KAKENHI-PROJECT-21K08948, KAKENHI-PROJECT-22K16602
[Journal Article] Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial2023
- Author(s)
  Matsumoto Ayumu、Satomi Shiho、Kakuta Nami、Narasaki Soshi、Toyota Yukari、Miyoshi Hirotsugu、Horikawa Yousuke T.、Saeki Noboru、Tanaka Katsuya、Tsutsumi Yasuo M.
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 12 Issue: 16 Pages: 5402-5402
- DOI
  10.3390/jcm12165402
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09047, KAKENHI-PROJECT-22K09048, KAKENHI-PROJECT-21K08948
[Journal Article] Rapid cyclic fluctuations in blood pressure during two surgeries associated with pheochromocytoma: a case report.2022
- Author(s)
  Watanabe T, Miyoshi H, Nakamura R, Otsuki S, Saeki N, and Tsutsumi YM.
- Journal Title
  
  JA Clin Rep
  
  Volume: 8 Issue: 1 Pages: 80-80
- DOI
  10.1186/s40981-022-00569-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09070
[Journal Article] Remimazolam requires less vasopressor support during induction and maintenance of general anesthesia in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement: A retrospective analysis from a single center.2022
- Author(s)
  Miyoshi H, Watanabe T, Kido K, Kamiya S, Otsuki S, Narasaki S, Toyota Y, Kondo T, Horikawa YT, Saeki N, Tsutsumi YM.
- Journal Title
  
  BioMed Res Int
  
  Volume: 2022 Issue: 1 Pages: 6386606-6386606
- DOI
  10.1155/2022/6386606
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08948, KAKENHI-PROJECT-22K09047, KAKENHI-PROJECT-22K09070
[Journal Article] Venous cannula occlusion during cardiopulmonary bypass recognized by ultrasonography of the internal jugular vein2022
- Author(s)
  Narasaki S, Miyoshi H, Nakamura R, Sumii A, Watanabe T, Otsuki S, and Tsutsumi YM. .
- Journal Title
  
  JA Clin Rep
  
  Volume: 8 Issue: 1 Pages: 29-29
- DOI
  10.1186/s40981-022-00519-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08948, KAKENHI-PROJECT-22K09070
[Journal Article] Characterization of intracellular calcium mobilization induced by remimazolam, a newly approved intravenous anesthetic2022
- Author(s)
  Urabe, T., Miyoshi, H., Narasaki, S., Yanase, Y., Uchida, K., Noguchi, S., Hide, M, Tsutsumi, M. Y. and Sakai, N.
- Journal Title
  
  PLos One
  
  Volume: 17 Issue: 2 Pages: e0263395-e0263395
- DOI
  10.1371/journal.pone.0263395
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03409, KAKENHI-PROJECT-21K08346, KAKENHI-PROJECT-21K08948, KAKENHI-PROJECT-22K09047, KAKENHI-PROJECT-21K16560
[Journal Article] Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling.2021
- Author(s)
  Morio A, Tsutsumi R, Kondo T, Miyoshi H, Kato T, Narasaki S, Satomi S, Nakaya E, Kuroda M, Sakaue H, Kitamura T, Tsutsumi YM
- Journal Title
  
  Nutr Metab Cardiovasc Dis
  
  Volume: 31 Issue: 10 Pages: 2979-2986
- DOI
  10.1016/j.numecd.2021.06.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09353, KAKENHI-PROJECT-19K18298, KAKENHI-PROJECT-19H04055, KAKENHI-PROJECT-21K08948, KAKENHI-PROJECT-20K19709, KAKENHI-PROJECT-21K20952
[Journal Article] Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model.2021
- Author(s)
  Morio A, Tsutsumi R, Satomi S, Kondo T, Miyoshi H, Kato T, Kuroda M, Kitamura T, Hara K, Saeki N, Sakaue H, and Tsutsumi YM
- Journal Title
  
  Diabetol Metab Syndr
  
  Volume: 13 Issue: 1 Pages: 39-39
- DOI
  10.1186/s13098-021-00755-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09353, KAKENHI-PROJECT-19K18298, KAKENHI-PROJECT-19H04055, KAKENHI-PROJECT-20K19709, KAKENHI-PROJECT-21K20952
[Journal Article] 腹部ステントグラフト内挿入後のType2エンドリークに対する開腹下の流入血管結紮・瘤縫縮術の麻酔経験2021
- Author(s)
  池田豪、三好寛二、森尾篤、楢崎壮志、野田祐子、神谷諭史、近藤隆志、加藤貴大、堤保夫
- Journal Title
  
  Cardiovascular Anesthesia
  
  Volume: 25 Pages: 89-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08948
[Journal Article] Branched-chain amino acids-induced cardiac protection against ischemia/reperfusion injury.2020
- Author(s)
  Satomi S, Morio A, Miyoshi H, Nakamura R, Tsutsumi R, Sakaue H, Yasuda T, Saeki N, Tsutsumi YM
- Journal Title
  
  Life Science
  
  Volume: 245 Pages: 117368-117368
- DOI
  10.1016/j.lfs.2020.117368
- NAID
  120006993613
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08856, KAKENHI-PROJECT-19H04055, KAKENHI-PROJECT-17K11909, KAKENHI-PROJECT-19K09353
[Journal Article] Assessment of postoperative nutritional status and physical function between open surgical aortic valve replacement and transcatheter aortic valve implantation in elderly patients2020
- Author(s)
  Mayu Sebe, Rie Tsutsumi, Takuro Oyama, Yousuke T. Horikawa, Yuta Uemura, Nami Kakuta, Yoko Sakai, Atsushi Morio, Hirotsugu Miyoshi, Takashi Kondo, Tomoaki Urabe, Yuko Noda, Satoshi Kamiya, Noboru Saeki, Masashi Kuroda, Katsuya Tanaka, Yasuo M. Tsutsumi, and Hiroshi Sakaue.
- Journal Title
  
  J. Med. Invest.
  
  Volume: 67 Issue: 1.2 Pages: 139-144
- DOI
  10.2152/jmi.67.139
- NAID
  130007839863
- ISSN
  1343-1420, 1349-6867
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08817, KAKENHI-PROJECT-19K09353, KAKENHI-PROJECT-18K16450, KAKENHI-PROJECT-18K16483, KAKENHI-PROJECT-19H04055
[Presentation] Genetic panel testing of malignant hyperthermia patients in Japan2024
- Author(s)
  Ayako Sumii, Hirotsugu Miyoshi, Keiko Mukaida, Tsuyoshi Ikeda, Kenshiro Kido, Yuko Noda, Toshimichi Yasuda, Sachiko Otsuki, Rieko Kanzaki, Yasuo Tsutsumi
- Organizer
  18th World Congress of Anaesthesiologists
- Data Source
  KAKENHI-PROJECT-23K08332
[Presentation] Current status of muscle contraction testing and functional analysis of malignant hyperthermia-related gene variants in East Asia2024
- Author(s)
  三好寛二、野田祐子, Sophia Tsong Huey Chew, Wei Keang Tan, Sidharta Manggala, Lian Kah Ti, Pei-Lung Chen, Huei-Ming Yeh, Jen-Hao Liu, Asian Malignant Hyperthermia Alliance (AMHA)
- Organizer
  18th World Congress of Anaesthesiologists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16602
[Presentation] Genetic panel testing of malignant hyperthermia patients in Japan2024
- Author(s)
  Ayako Sumii, Hirotsugu Miyoshi, Keiko Mukaida, Tsuyoshi Ikeda, Kenshiro Kido, Yuko Noda, Toshimichi Yasuda, Sachiko Otsuki, Rieko Kanzaki, Yasuo Tsutsumi
- Organizer
  18th World Congress of Anaesthesiologists (WCA2024)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09095
[Presentation] Genetic panel testing of malignant hyperthermia　patients in Japan2024
- Author(s)
  住井彩子、三好寛二、向田圭子、池田豪、城戸健士郎、野田祐子、安田季道、大月幸子、神崎理英子、堤保夫
- Organizer
  18th World Congress of Anaesthesiologists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16602
[Presentation] リアノジン受容体1型遺伝子変異マウスにおける悪性高熱症の発症様式にセボフルラン濃度および性差が及ぼす影響2023
- Author(s)
  三好寛二、城戸健士郎、渡辺知幸、向田圭子、安田季道、堤保夫
- Organizer
  日本麻酔科学会第70回学術集会
- Data Source
  KAKENHI-PROJECT-22K16602
[Presentation] セボフルランおよびデスフルラン投与によるリアノジン受容体1型遺伝子変異マウスにおける悪性高熱症発症様式の比較2023
- Author(s)
  城戸健士郎、三好寛二、渡辺知幸、向田圭子、安田季道、堤保夫
- Organizer
  日本麻酔科学会第70回学術集会
- Data Source
  KAKENHI-PROJECT-22K16602
[Presentation] Investigating patients with malignant hyperthermia by gene panel testing in Japan2023
- Author(s)
  三好寛二、向田圭子、野田祐子、城戸健士郎、住井彩子、神崎理英子、安田季道、堤保夫
- Organizer
  41th Annual European Malignant Hyperthermia EMHG
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16602
[Presentation] セボフルランおよびデスフルラン投与によるリアノジン受容体1型遺伝子変異マウスにおける悪性高熱症発症様式の比較2023
- Author(s)
  城戸健士郎、三好寛二、渡辺知幸、向田圭子、安田季道、堤保夫
- Organizer
  日本麻酔科学会第70回学術集会
- Data Source
  KAKENHI-PROJECT-22K16602
[Presentation] 悪性高熱症原因遺伝子であるジヒドロピリジン受容体遺伝子の変異R174W機能解析2023
- Author(s)
  向田圭子、大月幸子、野田祐子、神崎理英子、三好寛二、堤保夫
- Organizer
  日本麻酔科学会第70回学術集会
- Data Source
  KAKENHI-PROJECT-22K09095
[Presentation] 悪性高熱症原因遺伝子であるジヒドロピリジン受容体遺伝子の変異R174W機能解析2023
- Author(s)
  向田圭子、大月幸子、野田祐子、神崎理英子、三好寛二、堤保夫
- Organizer
  本麻酔科学会第70回学術集会
- Data Source
  KAKENHI-PROJECT-23K08332
[Presentation] 遺伝子パネル検査による悪性高熱症関連遺伝子変異の探索2023
- Author(s)
  住井彩子、三好寛二、向田圭子、安田季道、神崎理英子、堤保夫
- Organizer
  日本麻酔科学会第70回学術集会
- Data Source
  KAKENHI-PROJECT-22K16602
[Presentation] リアノジン受容体1型遺伝子変異マウスにおける悪性高熱症の発症様式にセボフルラン濃度および性差が及ぼす影響2023
- Author(s)
  三好寛二、城戸健士郎、渡辺知幸、向田圭子、安田季道、堤保夫
- Organizer
  日本麻酔科学会第70回学術集会
- Data Source
  KAKENHI-PROJECT-22K16602
[Presentation] Protein kinase C (PKC) domains involved in propofol-induced PKC translocation.2022
- Author(s)
  Narasaki S, Sakai N, Miyoshi H, Ishii T, Tsutsumi Y.
- Organizer
  Asian Australasian Congress of Anaesthesiologists 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08948
[Presentation] Effect of remimazolam on intracellular calcium regulation of cultured skeletal muscle cells in patients with predisposition to malignant hyperthermia.2022
- Author(s)
  Watanabe T, Miyoshi H, Mukaida K, Kido K, Otsuki S, Yasuda T, Tsutsumi Y
- Organizer
  Asian Australasian Congress of Anaesthesiologists 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09070
[Presentation] 経カテーテル的大動脈弁留置術における術者の習熟が術後経過に及ぼす影響2021
- Author(s)
  岡野良子、神谷諭史、三好寛二、楢崎壮志、近藤隆志、渡辺知幸、堤保夫
- Organizer
  第26回日本心臓血管麻酔学会
- Data Source
  KAKENHI-PROJECT-21K08948

1. TSUTSUMI Yasuo (90523499)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
2. 大月幸子 (90774018)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. NARASAKI Soshi (30887964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 森尾篤 (60868389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 渡辺知幸 (10897911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 神崎理英子 (70751402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 向田圭子 (20182066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 村山尚 (10230012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YASUDA Toshimichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 近藤隆志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 秀和泉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 酒井規雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 里見志帆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyoshi Hirotugu 三好 寛二

Miyoshi Hirotsugu 三好 寛二

Research Projects

Research Products

Co-Researchers

全ゲノムシークエンスによる悪性高熱症の新規原因遺伝子変異の検索とその機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for novel variants and their functional analysis by malignant hyperthermia-associated gene panel test

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the effect of aging on the development of malignant hyperthermia in RYR1 knock-in mouse.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規原因遺伝子に対する悪性高熱症の機能解析実験系の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

悪性高熱症の原因遺伝子としてのSTAC3・TRPV1の関与の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of TRPV1 channel function in the mechanism of malignant hyperthermiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of microdomains and anesthetics on energy metabolism in cardiac hypertrophy.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cardiac protection by volatile anesthetic -Role of caveolae and mitochondrial regulation-

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Rapid dantrolene administration with body temperature monitoring is associated with decreased mortality in Japanese malignant hyperthermia events.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of Remimazolam on Intracellular Calcium Dynamics in Myotubes Derived from Patients with Malignant Hyperthermia and Functional Analysis of Type 1 Ryanodine Receptor Gene Variants2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid cyclic fluctuations in blood pressure during two surgeries associated with pheochromocytoma: a case report.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Remimazolam requires less vasopressor support during induction and maintenance of general anesthesia in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement: A retrospective analysis from a single center.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Venous cannula occlusion during cardiopulmonary bypass recognized by ultrasonography of the internal jugular vein2022

Author(s)

Miyoshi Hirotugu 三好寛二

Miyoshi Hirotsugu 三好寛二

[Presentation] Genetic panel testing of malignant hyperthermia　patients in Japan2024