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Miyoshi Hirotugu  三好 寛二

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Miyoshi Hirotsugu  三好 寛二

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Researcher Number 50645364
Other IDs
Affiliation (Current) 2025: 広島大学, 病院(医), 講師
Affiliation (based on the past Project Information) *help 2025: 広島大学, 病院(医), 講師
2022 – 2023: 広島大学, 病院(医), 講師
2021: 広島大学, 医系科学研究科(医), 助教
Review Section/Research Field
Principal Investigator
Basic Section 55050:Anesthesiology-related
Except Principal Investigator
Basic Section 55050:Anesthesiology-related
Keywords
Principal Investigator
熱ストレス / リアノジン受容体 / うつ熱 / TRPV1受容体 / カプサイシン受容体 / 遺伝子変異 / 遺伝子解析 / TRPV1 / 悪性高熱症
Except Principal Investigator
悪性高熱症 … More / 吸入麻酔薬 / CACNA1S / RYR1 / ノックインマウス / 虚血再灌流障害 / 細胞膜マイクロドメイン / 加齢 / 遺伝子 / 骨格筋 / カルシウム / 遺伝子パネル検査 / NGS / TRPV1 / STAC3 / 遺伝子解析 / 原因遺伝子 / リアノジン受容体 / 遺伝子変異 / ジヒドロピリジン受容体 / 脂肪酸 / グルコース / エネルギー代謝 / 心肥大 / マイクロドメイン / カベオラ・カベオリン / ミトコンドリア / 心筋保護作用 Less
  • Research Projects

    (8 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (13 People)
  •  全ゲノムシークエンスによる悪性高熱症の新規原因遺伝子変異の検索とその機能解析Principal Investigator

    • Principal Investigator
      三好 寛二
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Hiroshima University
  •  Search for novel variants and their functional analysis by malignant hyperthermia-associated gene panel test

    • Principal Investigator
      向田 圭子
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Hiroshima University
  •  Investigation of the effect of aging on the development of malignant hyperthermia in RYR1 knock-in mouse.

    • Principal Investigator
      大月 幸子
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Hiroshima University
  •  新規原因遺伝子に対する悪性高熱症の機能解析実験系の確立

    • Principal Investigator
      渡辺 知幸
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Hiroshima University
  •  悪性高熱症の原因遺伝子としてのSTAC3・TRPV1の関与の探索

    • Principal Investigator
      神崎 理英子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Hiroshima University
  •  Elucidation of TRPV1 channel function in the mechanism of malignant hyperthermiaPrincipal Investigator

    • Principal Investigator
      Miyoshi Hirotsugu
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Hiroshima University
  •  Effects of microdomains and anesthetics on energy metabolism in cardiac hypertrophy.

    • Principal Investigator
      NARASAKI Soshi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Hiroshima University
  •  Cardiac protection by volatile anesthetic -Role of caveolae and mitochondrial regulation-

    • Principal Investigator
      TSUTSUMI Yasuo
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Hiroshima University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

  • [Journal Article] Rapid dantrolene administration with body temperature monitoring is associated with decreased mortality in Japanese malignant hyperthermia events.2023

    • Author(s)
      Toyota Y, Kondo T, Shorin D, Sumii A, Kido K, Watanabe T, Otsuki S, Kanzaki R, Miyoshi H, Yasuda T, Horikawa YT, Mukaida K, Tsutsumi YM.
    • Journal Title

      BioMed Res Int

      Volume: 2023 Issue: 1 Pages: 8340209-8340209

    • DOI

      10.1155/2023/8340209

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K09047, KAKENHI-PROJECT-22K09070, KAKENHI-PROJECT-22K09095
  • [Journal Article] Effects of Remimazolam on Intracellular Calcium Dynamics in Myotubes Derived from Patients with Malignant Hyperthermia and Functional Analysis of Type 1 Ryanodine Receptor Gene Variants2023

    • Author(s)
      Miyoshi Hirotsugu、Otsuki Sachiko、Mukaida Keiko、Kido Kenshiro、Sumii Ayako、Ikeda Tsuyoshi、Noda Yuko、Yasuda Toshimichi、Narasaki Soshi、Kato Takahiro、Kamiya Satoshi、Horikawa Yousuke T.、Tsutsumi Yasuo M.
    • Journal Title

      Genes

      Volume: 14 Issue: 11 Pages: 2009-2009

    • DOI

      10.3390/genes14112009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09047, KAKENHI-PROJECT-23K08332, KAKENHI-PROJECT-21K08948, KAKENHI-PROJECT-22K16602
  • [Journal Article] Remimazolam’s Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial2023

    • Author(s)
      Matsumoto Ayumu、Satomi Shiho、Kakuta Nami、Narasaki Soshi、Toyota Yukari、Miyoshi Hirotsugu、Horikawa Yousuke T.、Saeki Noboru、Tanaka Katsuya、Tsutsumi Yasuo M.
    • Journal Title

      Journal of Clinical Medicine

      Volume: 12 Issue: 16 Pages: 5402-5402

    • DOI

      10.3390/jcm12165402

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09047, KAKENHI-PROJECT-22K09048, KAKENHI-PROJECT-21K08948
  • [Journal Article] Rapid cyclic fluctuations in blood pressure during two surgeries associated with pheochromocytoma: a case report.2022

    • Author(s)
      Watanabe T, Miyoshi H, Nakamura R, Otsuki S, Saeki N, and Tsutsumi YM.
    • Journal Title

      JA Clin Rep

      Volume: 8 Issue: 1 Pages: 80-80

    • DOI

      10.1186/s40981-022-00569-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09070
  • [Journal Article] Remimazolam requires less vasopressor support during induction and maintenance of general anesthesia in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement: A retrospective analysis from a single center.2022

    • Author(s)
      Miyoshi H, Watanabe T, Kido K, Kamiya S, Otsuki S, Narasaki S, Toyota Y, Kondo T, Horikawa YT, Saeki N, Tsutsumi YM.
    • Journal Title

      BioMed Res Int

      Volume: 2022 Issue: 1 Pages: 6386606-6386606

    • DOI

      10.1155/2022/6386606

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08948, KAKENHI-PROJECT-22K09047, KAKENHI-PROJECT-22K09070
  • [Journal Article] Venous cannula occlusion during cardiopulmonary bypass recognized by ultrasonography of the internal jugular vein2022

    • Author(s)
      Narasaki S, Miyoshi H, Nakamura R, Sumii A, Watanabe T, Otsuki S, and Tsutsumi YM. .
    • Journal Title

      JA Clin Rep

      Volume: 8 Issue: 1 Pages: 29-29

    • DOI

      10.1186/s40981-022-00519-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08948, KAKENHI-PROJECT-22K09070
  • [Journal Article] Characterization of intracellular calcium mobilization induced by remimazolam, a newly approved intravenous anesthetic2022

    • Author(s)
      Urabe, T., Miyoshi, H., Narasaki, S., Yanase, Y., Uchida, K., Noguchi, S., Hide, M, Tsutsumi, M. Y. and Sakai, N.
    • Journal Title

      PLos One

      Volume: 17 Issue: 2 Pages: e0263395-e0263395

    • DOI

      10.1371/journal.pone.0263395

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03409, KAKENHI-PROJECT-21K08346, KAKENHI-PROJECT-21K08948, KAKENHI-PROJECT-22K09047, KAKENHI-PROJECT-21K16560
  • [Journal Article] Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling.2021

    • Author(s)
      Morio A, Tsutsumi R, Kondo T, Miyoshi H, Kato T, Narasaki S, Satomi S, Nakaya E, Kuroda M, Sakaue H, Kitamura T, Tsutsumi YM
    • Journal Title

      Nutr Metab Cardiovasc Dis

      Volume: 31 Issue: 10 Pages: 2979-2986

    • DOI

      10.1016/j.numecd.2021.06.025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09353, KAKENHI-PROJECT-19K18298, KAKENHI-PROJECT-19H04055, KAKENHI-PROJECT-21K08948, KAKENHI-PROJECT-20K19709, KAKENHI-PROJECT-21K20952
  • [Journal Article] Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model.2021

    • Author(s)
      Morio A, Tsutsumi R, Satomi S, Kondo T, Miyoshi H, Kato T, Kuroda M, Kitamura T, Hara K, Saeki N, Sakaue H, and Tsutsumi YM
    • Journal Title

      Diabetol Metab Syndr

      Volume: 13 Issue: 1 Pages: 39-39

    • DOI

      10.1186/s13098-021-00755-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09353, KAKENHI-PROJECT-19K18298, KAKENHI-PROJECT-19H04055, KAKENHI-PROJECT-20K19709, KAKENHI-PROJECT-21K20952
  • [Journal Article] 腹部ステントグラフト内挿入後のType2エンドリークに対する開腹下の流入血管結紮・瘤縫縮術の麻酔経験2021

    • Author(s)
      池田豪、三好寛二、森尾篤、楢崎壮志、野田祐子、神谷諭史、近藤隆志、加藤貴大、堤保夫
    • Journal Title

      Cardiovascular Anesthesia

      Volume: 25 Pages: 89-93

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K08948
  • [Journal Article] Branched-chain amino acids-induced cardiac protection against ischemia/reperfusion injury.2020

    • Author(s)
      Satomi S, Morio A, Miyoshi H, Nakamura R, Tsutsumi R, Sakaue H, Yasuda T, Saeki N, Tsutsumi YM
    • Journal Title

      Life Science

      Volume: 245 Pages: 117368-117368

    • DOI

      10.1016/j.lfs.2020.117368

    • NAID

      120006993613

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08856, KAKENHI-PROJECT-19H04055, KAKENHI-PROJECT-17K11909, KAKENHI-PROJECT-19K09353
  • [Journal Article] Assessment of postoperative nutritional status and physical function between open surgical aortic valve replacement and transcatheter aortic valve implantation in elderly patients2020

    • Author(s)
      Mayu Sebe, Rie Tsutsumi, Takuro Oyama, Yousuke T. Horikawa, Yuta Uemura, Nami Kakuta, Yoko Sakai, Atsushi Morio, Hirotsugu Miyoshi, Takashi Kondo, Tomoaki Urabe, Yuko Noda, Satoshi Kamiya, Noboru Saeki, Masashi Kuroda, Katsuya Tanaka, Yasuo M. Tsutsumi, and Hiroshi Sakaue.
    • Journal Title

      J. Med. Invest.

      Volume: 67 Issue: 1.2 Pages: 139-144

    • DOI

      10.2152/jmi.67.139

    • NAID

      130007839863

    • ISSN
      1343-1420, 1349-6867
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08817, KAKENHI-PROJECT-19K09353, KAKENHI-PROJECT-18K16450, KAKENHI-PROJECT-18K16483, KAKENHI-PROJECT-19H04055
  • [Presentation] Genetic panel testing of malignant hyperthermia patients in Japan2024

    • Author(s)
      Ayako Sumii, Hirotsugu Miyoshi, Keiko Mukaida, Tsuyoshi Ikeda, Kenshiro Kido, Yuko Noda, Toshimichi Yasuda, Sachiko Otsuki, Rieko Kanzaki, Yasuo Tsutsumi
    • Organizer
      18th World Congress of Anaesthesiologists
    • Data Source
      KAKENHI-PROJECT-23K08332
  • [Presentation] Current status of muscle contraction testing and functional analysis of malignant hyperthermia-related gene variants in East Asia2024

    • Author(s)
      三好寛二、野田祐子, Sophia Tsong Huey Chew, Wei Keang Tan, Sidharta Manggala, Lian Kah Ti, Pei-Lung Chen, Huei-Ming Yeh, Jen-Hao Liu, Asian Malignant Hyperthermia Alliance (AMHA)
    • Organizer
      18th World Congress of Anaesthesiologists
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K16602
  • [Presentation] Genetic panel testing of malignant hyperthermia patients in Japan2024

    • Author(s)
      Ayako Sumii, Hirotsugu Miyoshi, Keiko Mukaida, Tsuyoshi Ikeda, Kenshiro Kido, Yuko Noda, Toshimichi Yasuda, Sachiko Otsuki, Rieko Kanzaki, Yasuo Tsutsumi
    • Organizer
      18th World Congress of Anaesthesiologists (WCA2024)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K09095
  • [Presentation] Genetic panel testing of malignant hyperthermia patients in Japan2024

    • Author(s)
      住井彩子、三好寛二、向田圭子、池田豪、城戸健士郎、野田祐子、安田季道、大月幸子、神崎理英子、堤保夫
    • Organizer
      18th World Congress of Anaesthesiologists
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K16602
  • [Presentation] リアノジン受容体1型遺伝子変異マウスにおける悪性高熱症の発症様式にセボフルラン濃度および性差が及ぼす影響2023

    • Author(s)
      三好寛二、城戸健士郎、渡辺知幸、向田圭子、安田季道、堤 保夫
    • Organizer
      日本麻酔科学会 第70回学術集会
    • Data Source
      KAKENHI-PROJECT-22K16602
  • [Presentation] セボフルランおよびデスフルラン投与によるリアノジン受容体1型遺伝子変異マウスにおける悪性高熱症発症様式の比較2023

    • Author(s)
      城戸健士郎、三好寛二、渡辺知幸、向田圭子、安田季道、堤 保夫
    • Organizer
      日本麻酔科学会第70回学術集会
    • Data Source
      KAKENHI-PROJECT-22K16602
  • [Presentation] Investigating patients with malignant hyperthermia by gene panel testing in Japan2023

    • Author(s)
      三好寛二、向田圭子、野田祐子、城戸健士郎、住井彩子、神崎理英子、安田季道、堤 保夫
    • Organizer
      41th Annual European Malignant Hyperthermia EMHG
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K16602
  • [Presentation] セボフルランおよびデスフルラン投与によるリアノジン受容体1型遺伝子変異マウスにおける悪性高熱症発症様式の比較2023

    • Author(s)
      城戸健士郎、三好寛二、渡辺知幸、向田圭子、安田季道、堤 保夫
    • Organizer
      日本麻酔科学会 第70回学術集会
    • Data Source
      KAKENHI-PROJECT-22K16602
  • [Presentation] 悪性高熱症原因遺伝子であるジヒドロピリジン受容体遺伝子の変異R174W機能解析2023

    • Author(s)
      向田 圭子、大月 幸子、野田 祐子、神崎 理英子、三好 寛二、堤 保夫
    • Organizer
      日本麻酔科学会第70回学術集会
    • Data Source
      KAKENHI-PROJECT-22K09095
  • [Presentation] 悪性高熱症原因遺伝子であるジヒドロピリジン受容体遺伝子の変異R174W機能解析2023

    • Author(s)
      向田 圭子、大月 幸子、野田 祐子、神崎 理英子、三好 寛二、堤 保夫
    • Organizer
      本麻酔科学会第70回学術集会
    • Data Source
      KAKENHI-PROJECT-23K08332
  • [Presentation] 遺伝子パネル検査による悪性高熱症関連遺伝子変異の探索2023

    • Author(s)
      住井彩子、三好寛二、向田圭子、安田季道、神崎理英子、堤 保夫
    • Organizer
      日本麻酔科学会 第70回学術集会
    • Data Source
      KAKENHI-PROJECT-22K16602
  • [Presentation] リアノジン受容体1型遺伝子変異マウスにおける悪性高熱症の発症様式にセボフルラン濃度およ び性差が及ぼす影響2023

    • Author(s)
      三好寛二、城戸健士郎、渡辺知幸、向田圭子、安田季道、堤 保夫
    • Organizer
      日本麻酔科学会第70回学術集会
    • Data Source
      KAKENHI-PROJECT-22K16602
  • [Presentation] Protein kinase C (PKC) domains involved in propofol-induced PKC translocation.2022

    • Author(s)
      Narasaki S, Sakai N, Miyoshi H, Ishii T, Tsutsumi Y.
    • Organizer
      Asian Australasian Congress of Anaesthesiologists 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08948
  • [Presentation] Effect of remimazolam on intracellular calcium regulation of cultured skeletal muscle cells in patients with predisposition to malignant hyperthermia.2022

    • Author(s)
      Watanabe T, Miyoshi H, Mukaida K, Kido K, Otsuki S, Yasuda T, Tsutsumi Y
    • Organizer
      Asian Australasian Congress of Anaesthesiologists 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K09070
  • [Presentation] 経カテーテル的大動脈弁留置術における術者の習熟が術後経過に及ぼす影響2021

    • Author(s)
      岡野良子、神谷諭史、三好寛二、楢崎壮志、近藤隆志、渡辺知幸、堤保夫
    • Organizer
      第26回日本心臓血管麻酔学会
    • Data Source
      KAKENHI-PROJECT-21K08948
  • 1.  TSUTSUMI Yasuo (90523499)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 14 results
  • 2.  大月 幸子 (90774018)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 3.  NARASAKI Soshi (30887964)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 4.  森尾 篤 (60868389)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  渡辺 知幸 (10897911)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  神崎 理英子 (70751402)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  向田 圭子 (20182066)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 8.  村山 尚 (10230012)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  YASUDA Toshimichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  近藤 隆志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  秀 和泉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  酒井 規雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  里見 志帆
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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