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Murayama Takashi  村山 尚

… Alternative Names

MURAYAMA Takashi  村山 尚

村山 尚  ミラヤマ タカシ

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Researcher Number 10230012
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-3845-2980
Affiliation (Current) 2022: 順天堂大学, 医学部, 先任准教授
Affiliation (based on the past Project Information) *help 2021 – 2022: 順天堂大学, 医学部, 先任准教授
2016 – 2021: 順天堂大学, 医学部, 准教授
2007 – 2014: Juntendo University, Department of Pharmacology, Associate Professor
2005 – 2006: 順天堂大学, 医学部, 講師
1998 – 2001: 順天堂大学, 医学部, 講師
1996: 順天堂大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
General pharmacology / General pharmacology / Basic Section 48020:Physiology-related / Neurophysiology and muscle physiology / General physiology
Except Principal Investigator
General pharmacology / Biological Sciences / Neurology / Nerve anatomy/Neuropathology / General physiology … More / General physiology / Basic Section 47040:Pharmacology-related / Basic Section 48020:Physiology-related / Basic Section 43020:Structural biochemistry-related / Transformative Research Areas, Section (II) / Basic Section 59010:Rehabilitation science-related Less
Keywords
Principal Investigator
リアノジン受容体 / カルシウムチャネル / 筋小胞体 / 興奮収縮連関 / カルシウムイオン / 骨格筋 / 相互作用 / イオンチャネル / 構造解析 / 血管 … More / 平滑筋 / アイソフォーム / 蛍光プローブ / イノシトール3リン酸受容体 / 容量性カルシウム流入 / transient receptor potential / 悪性高熱 / 小胞体 / 人工アミノ酸 / 不整脈 / S4-S5リンカー / 心肥大 / 心不全 / 細胞内カルシウム / カルモジュリン / 細胞内Ca2+ / cardiac hypertrophy / heart failure / ryanodine receptor / calcium ion / sarcoplasmic reticulum / 動作原理 / 心筋 / 構造活性相関 / 筋疾患 / カフェイン / カルシウム / 疾患変異 / 作動機構 / 構造モデル / チャネル / 創薬 / サブタイプ / 機能解析 / クライオ電子顕微鏡 / カルシウム遊離チャネル … More
Except Principal Investigator
カルシウム / リアノジン受容体 / 不整脈 / 筋小胞体 / パールカン / ミオトニア / カテコラミン誘発性多型性心室頻拍 / 抗不整脈薬 / 心臓 / Alternans / 悪性高熱症 / ヘパラン硫酸プロテオグリカン / マウスモデル / 棟鎖 / カルシウムシグナル / 筋収縮 / 平滑筋 / 細胞外マトリックス / 筋疾患 / 基底膜 / 脳神経疾患 / 認知症 / 脂質 / アルツハイマー病 / 痴呆 / 心筋 / ライブイメージング / Ca2+遊離 / シングルチャネル電流 / システイン残基 / 酸化・還元電位 / 活性酸素 / シングルチャネル活性 / アデニンヌクレオチド / グルタンチオン / チャネル活性 / 酸化還元電位 / Ryanodine receptor / single channel current / cysteine residue / redox potential / Ca^<2+>オーバーロード / コネキシン / 伝導障害 / 活動電位 / 心房細動 / Ca^2+オーバロード / alternans / Arrhythmia / Ca^<2+> overload / Connexin / Abnormal conductance / Action potentia / Calcium ion / Atrial fibrillation / TRPM7 / 平面膜 / キナーゼドメイン / 分子内相互作用 / 酸化ストレス / チャネル / シングルチャネル / RyR2阻害薬 / モデルマウス / 細胞内カルシウム動態 / 大規模スクリーニング / 熱 / リアノジン / 分子動力学計算 / 膜蛋白質 / カルシウムチャネル / イオンチャネル / クライオ電子顕微鏡 / 顕微解析システム / 運動療法 / 拡張型心筋症 / 心不全 / レニン・アンギオテンシン阻害薬 / 心室性不整脈 Less
  • Research Projects

    (21 results)
  • Research Products

    (146 results)
  • Co-Researchers

    (89 People)
  •  Elucidation of molecular mechanism for depolarization-induced Ca2+ release using novel reconstitution systemPrincipal Investigator

    • Principal Investigator
      村山 尚
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48020:Physiology-related
    • Research Institution
      Juntendo University
  •  筋肉熱シグナリング破綻・暴走の個体解析

    • Principal Investigator
      山澤 徳志子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      Jikei University School of Medicine
  •  Structural analysis of the gating mechanism of cardiac ryanodine receptor

    • Principal Investigator
      小川 治夫
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43020:Structural biochemistry-related
    • Research Institution
      Kyoto University
  •  The construction of exercise therapy in familial DCM model mice

    • Principal Investigator
      杉原 匡美
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59010:Rehabilitation science-related
    • Research Institution
      Juntendo University
  •  Effectiveness of RyR2 inhibitors as antiarrhytmic drugs

    • Principal Investigator
      呉林 なごみ
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Juntendo University
  •  生理実験と分子動力学計算を組み合わせた新規リアノジン受容体制御機構の解析

    • Principal Investigator
      山澤 徳志子
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48020:Physiology-related
    • Research Institution
      Jikei University School of Medicine
  •  新規リアノジン受容体作用薬を利用したサブタイプ特異的チャネル制御の分子機構Principal Investigator

    • Principal Investigator
      村山 尚
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48020:Physiology-related
    • Research Institution
      Juntendo University
  •  Regulation of TRPM7 channel activity in the lipid bilayers

    • Principal Investigator
      Inoue Hana
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      Tokyo Medical University
  •  Elucidation of ryanodine receptor channel gating mechanism at atomic levelPrincipal Investigator

    • Principal Investigator
      Murayama Takashi
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      Juntendo University
  •  Elucidation of regulatory mechanisms of type 2 ryanodine receptors by introducing artificial amino acidsPrincipal Investigator

    • Principal Investigator
      MURAYAMA Takashi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Juntendo University
  •  Exploration of anti-arrhythmic drugs acting on RyR2 using myocardium and cultured cells.

    • Principal Investigator
      KUREBAYASHI Nagomi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Juntendo University
  •  Microdomain-dependent acceleration mechanisms for amyloidogenic processing of amyloid precursor protein induced by endocytic membrane traffic impairment

    • Principal Investigator
      SAKURAI Takashi
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Juntendo University
  •  Regulation of ryanodine receptor channel by interdomain interactionPrincipal Investigator

    • Principal Investigator
      MURAYAMA Takashi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurophysiology and muscle physiology
    • Research Institution
      Juntendo University
  •  Role of calcium homeostasis in Schwartz-Jampel syndrome

    • Principal Investigator
      HIRASAWA Eri
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Juntendo University
  •  An experimental study for the mechanism of atrial fibrillation and its control by means of optical imaging of cell-to-cell communication

    • Principal Investigator
      KUREBAYASHI Nagomi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Juntendo University
  •  ヘパラン硫酸プロテオグリカン、パールカンによる筋収縮シグナル制御の研究

    • Principal Investigator
      HIRASAWA Eri
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University
  •  Molecular mechanisms underlying abnormal functions in RyR2 complex in cardiac hypertrophy/heart failurePrincipal Investigator

    • Principal Investigator
      MURAYAMA Takashi
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Juntendo University
  •  DO CYSTEINES LOCATED NEAR THE CHANNEL PORE OF THE RYANODINE RECEPTOR FUNCTION AS TARGET AMINO ACID FOR REACTIVE OXYGEN SPECIES?

    • Principal Investigator
      OBA Toshiharu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      NAGOYA GITY UNIVERSITY
  •  蛍光プローブによるCa^<2+>放出チャネルタンパク質の機能分担の解明Principal Investigator

    • Principal Investigator
      村山 尚
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Juntendo University
  •  哺乳類における容量性Ca^<2+>流入機構の解明Principal Investigator

    • Principal Investigator
      村山 尚
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General pharmacology
    • Research Institution
      Juntendo University
  •  血管平滑筋におけるリアノジン受容体アイソフォームの役割の検討Principal Investigator

    • Principal Investigator
      村山 尚
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General pharmacology
    • Research Institution
      Juntendo University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Patent

  • [Book] "Encyclopedia of Molecular Pharmacology"Ryanodine receptor2008

    • Author(s)
      Murayama T, Kurebayashi N, Ogawa Y
    • Publisher
      Springer,Berlin
    • Data Source
      KAKENHI-PROJECT-18590241
  • [Book] Ryanodine receptor"Encyclopedia of Molecular Pharmacology"2nd ed.2008

    • Author(s)
      Murayama Takashi
    • Publisher
      Springer,Berlin
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590241
  • [Journal Article] Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR22022

    • Author(s)
      Kurebayashi Nagomi、Murayama Takashi、Ota Ryosaku、Suzuki Junji、Kanemaru Kazunori、Kobayashi Takuya、Ohno Seiko、Horie Minoru、Iino Masamitsu、Yamashita Fumiyoshi、Sakurai Takashi
    • Journal Title

      Journal of General Physiology

      Volume: 154

    • DOI

      10.1085/jgp.202112869

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07105
  • [Journal Article] Differential effects of the formin inhibitor SMIFH2 on contractility and Ca2+ handling in frog and mouse cardiomyocytes2021

    • Author(s)
      Sakata Koji、Matsuyama Sho、Kurebayashi Nagomi、Hayamizu Kengo、Murayama Takashi、Nakamura Kunihide、Kitamura Kazuo、Morimoto Sachio、Takeya Ryu
    • Journal Title

      Genes to Cells

      Volume: 26 Pages: 583-595

    • DOI

      10.1111/gtc.12873

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07297, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K07355
  • [Journal Article] Sudden death after inappropriate shocks of implantable cardioverter defibrillator in a catecholaminergic polymorphic ventricular tachycardia case with a novel RyR2 mutation2021

    • Author(s)
      Itoh Hideki、Murayama Takashi、Kurebayashi Nagomi、Ohno Seiko、Kobayashi Takuya、Fujii Yusuke、Watanabe Masaya、Ogawa Haruo、Anzai Toshihisa、Horie Minoru
    • Journal Title

      Journal of Electrocardiology

      Volume: 69 Pages: 111-118

    • DOI

      10.1016/j.jelectrocard.2021.09.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-20K08473
  • [Journal Article] A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke2021

    • Author(s)
      Yamazawa Toshiko、Kobayashi Takuya、Kurebayashi Nagomi、Konishi Masato、Noguchi Satoru、Inoue Takayoshi、Inoue Yukiko U.、et al.
    • Journal Title

      Nature Communications

      Volume: 12 Pages: 4293-4293

    • DOI

      10.1038/s41467-021-24644-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-19H04922, KAKENHI-PROJECT-19H03198, KAKENHI-PROJECT-19K06955, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K07306, KAKENHI-PROJECT-20K06467, KAKENHI-PROJECT-20K11368, KAKENHI-PROJECT-21K19752
  • [Journal Article] Purification of Recombinant Wild Type and Mutant Ryanodine Receptors Expressed in HEK293 Cells2021

    • Author(s)
      Hu Yifan、Iyer Kavita、Nayak Ashok、Kurebayashi Nagomi、Murayama Takashi、Samso Montserrat
    • Journal Title

      BIO-PROTOCOL

      Volume: 11

    • DOI

      10.21769/bioprotoc.4112

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07105
  • [Journal Article] Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome2021

    • Author(s)
      Hirose Sayako、Murayama Takashi、Tetsuo Naoyuki、Hoshiai Minako、Kise Hiroaki、Yoshinaga Masao、Aoki Hisaaki、Fukuyama Megumi、Wuriyanghai Yimin、Wada Yuko、Kato Koichi、Makiyama Takeru、Kimura Takeshi、Sakurai Takashi、Horie Minoru、Kurebayashi Nagomi、Ohno Seiko
    • Journal Title

      EP Europace

      Volume: 24 Pages: 497-510

    • DOI

      10.1093/europace/euab250

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-19K08555, KAKENHI-PROJECT-21H02888, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-20K17113
  • [Journal Article] Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: possible functional interaction of dimerized endothelin A and μ-opioid receptors.2021

    • Author(s)
      Kuroda Y, Nonaka M, Kamikubo Y, Ogawa H, Murayama T, Kurebayashi N, Sakairi H, Miyano K, Komatsu A, Dodo T, Nakano-Ito K, Yamaguchi K, Sakurai T, Iseki M, Hayashida M, Uezono Y
    • Journal Title

      Biomedicine & Pharmacotherapy

      Volume: 141 Pages: 111800-111800

    • DOI

      10.1016/j.biopha.2021.111800

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08866, KAKENHI-PROJECT-19K16497, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-20K07765, KAKENHI-PROJECT-21K06584, KAKENHI-PROJECT-20K22745
  • [Journal Article] Enhanced CICR activity reduces ER Ca2+ level in cells expressing CPVT-linked mutant RyR22021

    • Author(s)
      Kurebayashi Nagomi、Murayama Takashi、Ohta Ryosaku、Suzuki Junji、Kanemaru Kazunori、Ohno Seiko、Horie Minoru、Iino Masamitsu、Yamashita Fumiyoshi、Sakurai Takashi
    • Journal Title

      Biorxiv

      Volume: -

    • DOI

      10.1101/2021.01.16.426980

    • Open Access
    • Data Source
      KAKENHI-PROJECT-19K07105
  • [Journal Article] Co-Phenotype of Left Ventricular Non-Compaction Cardiomyopathy and Atypical Catecholaminergic Polymorphic Ventricular Tachycardia in Association With R169Q, a Ryanodine Receptor Type 2 Missense Mutation2020

    • Author(s)
      Nozaki, Y. Kato, Y. Uike, K. Yamamura, K. Kikuchi, M. Yasuda, M. Ohno, S. Horie, M. Murayama, T. Kurebayashi, N. Horigome, H.
    • Journal Title

      Circulation Journal

      Volume: 84 Issue: 2 Pages: 226-234

    • DOI

      10.1253/circj.cj-19-0720

      10.1253/circj.CJ-19-0720

    • NAID

      130007789920

    • ISSN
      1346-9843, 1347-4820
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07813, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K19820, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-18K07875
  • [Journal Article] RyR2 mutation-linked arrhythmogenic diseases and its therapeutic strategies2020

    • Author(s)
      Kurebayashi Nagomi、Murayama Takashi
    • Journal Title

      Folia Pharmacol. Jpn.

      Volume: 155 Issue: 4 Pages: 225-229

    • DOI

      10.1254/fpj.20017

    • NAID

      130007867553

    • ISSN
      0015-5691, 1347-8397
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19H03404
  • [Journal Article] Molecular basis for gating and regulation of cardiac ryanodine receptor: underlying mechanisms for gain- and loss-of function mutations2020

    • Author(s)
      Kobayashi Takuya、Tsutsumi Akihisa、Kurebayashi Nagomi、Saito Kei、Kodama Masami、Sakurai Takashi、Kikkawa Masahide、Murayama Takashi、Ogawa Haruo
    • Journal Title

      Biorxiv

      Volume: -

    • DOI

      10.1101/2020.11.30.401026

    • Open Access
    • Data Source
      KAKENHI-PROJECT-19K07105
  • [Journal Article] TRIC-A channel maintains store calcium handling by interacting with type 2 ryanodine receptor in cardiac muscle.2020

    • Author(s)
      Zhou X, Park KH, Yamazaki D, Lin PH, Nishi M, Ma Z, Qiu L, Murayama T, Zou X, Takeshima H, Zhou J, Ma J.
    • Journal Title

      Circ. Res.

      Volume: 126 Pages: 417-435

    • DOI

      10.1161/circresaha.119.316241

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07313, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-17K01845, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-18H02597
  • [Journal Article] A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat stroke2020

    • Author(s)
      Yamazawa Toshiko、Kobayashi Takuya、Kurebayashi Nagomi、19人省略、Murayama Takashi
    • Journal Title

      Biorxiv

      Volume: -

    • DOI

      10.1101/2020.07.02.185520

    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07105
  • [Journal Article] Structural basis for diamide modulation of ryanodine receptor2020

    • Author(s)
      Ma Ruifang、Haji-Ghassemi Omid、Ma Dan、Jiang Heng、Lin Lianyun、Yao Li、Samurkas Arthur、Li Yuxin、Wang Yiwen、Cao Peng、Wu Shian、Zhang Yan、Murayama Takashi、Moussian Bernard、Van Petegem Filip、Yuchi Zhiguang
    • Journal Title

      Nature Chemical Biology

      Volume: 16 Pages: 1246-1254

    • DOI

      10.1038/s41589-020-0627-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03404
  • [Journal Article] Conformational diversity of dynactin sidearm and domain organization of its subunit p1502020

    • Author(s)
      Kei Saito, Takashi Murayama, Tomone Hata, Takuya Kobayashi, Keitaro Shibata, Saiko Kazuno, Tsutomu Fujimura, Takashi Sakurai, and Yoko Y. Toyoshima
    • Journal Title

      Molecular Biolofy of the Cell

      Volume: - Pages: 1218-1231

    • DOI

      10.1091/mbc.e20-01-0031

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19J13870, KAKENHI-PROJECT-17K00874, KAKENHI-PROJECT-20K05880, KAKENHI-PROJECT-19H03190, KAKENHI-PROJECT-19H03404
  • [Journal Article] Insights Into Channel Modulation Mechanism of RYR1 Mutants Using Ca2+ Imaging and Molecular Dynamics2020

    • Author(s)
      Yamazawa Toshiko、Ogawa Haruo、Murayama Takashi、Yamaguchi Maki、Oyamada Hideto、Suzuki Junji、Kurebayashi Nagomi、Kanemaru Kazunori、Oguchi Katsuji、Sakurai Takashi、Iino Masamitsu
    • Journal Title

      Journal of General Physiology

      Volume: 152 Pages: 0-0

    • DOI

      10.1085/jgp.201812235

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K07306, KAKENHI-PROJECT-19K09383, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-19H03198, KAKENHI-PROJECT-19H03404
  • [Journal Article] Regulatory mechanisms of ryanodine receptor/Ca2+ release channel revealed by recent advancements in structural studies.2020

    • Author(s)
      Ogawa Haruo、Kurebayashi Nagomi、Yamazawa Toshiko、Murayama Takashi
    • Journal Title

      J Muscle Res Cell Motil

      Volume: in press Pages: 0-0

    • DOI

      10.1007/s10974-020-09575-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K07306, KAKENHI-PROJECT-16H04748, KAKENHI-PROJECT-19H03404
  • [Journal Article] Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM2020

    • Author(s)
      Iyer Kavita A.、Hu Yifan、Nayak Ashok R.、Kurebayashi Nagomi、Murayama Takashi、Sams? Montserrat
    • Journal Title

      Science Advances

      Volume: 6 Pages: 0-0

    • DOI

      10.1126/sciadv.abb2964

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19H03404
  • [Journal Article] Dysfunction of muscle contraction with impaired intracellular Ca2+ handling in skeletal muscle and the effect of exercise training in male db/db mice.2019

    • Author(s)
      Eshima Hiroaki、Tamura Yoshifumi、Kakehi Saori、Nakamura Kyoko、Kurebayashi Nagomi、Murayama Takashi、Kakigi Ryo、Sakurai Takashi、Kawamori Ryuzo、Watada Hirotaka
    • Journal Title

      J Appl Physiol (1985)

      Volume: 126 Pages: 170-182

    • DOI

      10.1152/japplphysiol.00048.2018

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-18K11029
  • [Journal Article] Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay.2019

    • Author(s)
      Mori Shuichi、Iinuma Hiroto、Manaka Noriaki、Ishigami-Yuasa Mari、Murayama Takashi、Nishijima Yoshiaki、Sakurai Akiko、Arai Ryota、Kurebayashi Nagomi、Sakurai Takashi、Kagechika Hiroyuki
    • Journal Title

      Eur J Med Chem

      Volume: 179 Pages: 837-848

    • DOI

      10.1016/j.ejmech.2019.06.076

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-19H03404
  • [Journal Article] Assays for Modulators of Ryanodine Receptor (RyR)/Ca2+ Release Channel Activity for Drug Discovery for Skeletal Muscle and Heart Diseases2019

    • Author(s)
      Murayama Takashi、Kurebayashi Nagomi
    • Journal Title

      Current Protocols in Pharmacology

      Volume: 87 Pages: 0-0

    • DOI

      10.1002/cpph.71

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-19H03404
  • [Journal Article] Conversion of Ca2+ oscillation into propagative electrical signals by Ca2+-activated ion channels and connexin as a reconstituted Ca2+ clock model for the pacemaker activity2019

    • Author(s)
      Saeki Takanori、Kimura Taisuke、Hashidume Keigo、Murayama Takashi、Yamamura Hisao、Ohya Susumu、Suzuki Yoshiaki、Nakayama Shinsuke、Imaizumi Yuji
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 510 Pages: 242-247

    • DOI

      10.1016/j.bbrc.2019.01.080

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05537, KAKENHI-PROJECT-16H06215, KAKENHI-PROJECT-18J15415, KAKENHI-PROJECT-16K08278, KAKENHI-PROJECT-16K08285, KAKENHI-PROJECT-16K08507
  • [Journal Article] A tryptophan residue in the caffeine-binding site of the ryanodine receptor regulates Ca2+ sensitivity2018

    • Author(s)
      Murayama Takashi、Ogawa Haruo、Kurebayashi Nagomi、Ohno Seiko、Horie Minoru、Sakurai Takashi
    • Journal Title

      Commun Biol

      Volume: 1 Pages: 98-98

    • DOI

      10.1038/s42003-018-0103-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-15K08243
  • [Journal Article] Efficient high-throughput screening by ER Ca2+ measurement to identify inhibitors of ryanodine receptor Ca2+-release channels2018

    • Author(s)
      Murayama Takashi、Kurebayashi Nagomi、Ikegami-Yuasa Mari、Mori Shuichi、Suzuki Yukina、Akima Ryunosuke、Ogawa Haruo、Suzuki Junji、Kanemaru Kazunori、Oyamada Hideto、Kiuchi Yuji、Iino Masamitsu、Kagechika Hiroyuki、Sakurai Takashi
    • Journal Title

      Mol Pharmacol

      Volume: - Pages: 722-730

    • DOI

      10.1124/mol.117.111468

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08243, KAKENHI-PLANNED-25117002, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-18K06572, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-25221304
  • [Journal Article] A type 2 ryanodine receptor variant associated with reduced Ca2+ release and short-coupled torsades de pointes ventricular arrhythmia.2017

    • Author(s)
      Fujii Y, Horie M, et al.
    • Journal Title

      Heart Rhythm.

      Volume: 14 Pages: 98-107

    • DOI

      10.1016/j.hrthm.2016.10.015

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-25460406, KAKENHI-PROJECT-15K08243, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-15K09689
  • [Journal Article] Dynactin has two antagonistic regulatory domains and exerts opposing effects on dyenin motility2017

    • Author(s)
      Kobayashi Takuya、Miyashita Takuya、Murayama Takashi、Toyoshima Yoko Y.
    • Journal Title

      PLOS ONE

      Volume: 12

    • DOI

      10.1371/journal.pone.0183672

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-16H04772
  • [Journal Article] Fam64a is a novel cell cycle promoter of hypoxic fetal cardiomyocytes in mice.2017

    • Author(s)
      Hashimoto Ken、Kodama Aya、Honda Takeshi、Hanashima Akira、Ujihara Yoshihiro、Murayama Takashi、Nishimatsu Shin-ichiro、Mohri Satoshi
    • Journal Title

      Scientific Report

      Volume: 7 Pages: 4486-4486

    • DOI

      10.1038/s41598-017-04823-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K01385, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-17H02092, KAKENHI-PROJECT-17H04740
  • [Journal Article] Therapeutic potential of ghrelin and des-acyl ghrelin against chemotherapy-induced cardiotoxicity2017

    • Author(s)
      Nonaka Miki、Kurebayashi Nagomi、Murayama Takashi、Sugihara Masami、Terawaki Kiyoshi、Shiraishi Seiji、Miyano Kanako、Hosoda Hiroshi、Kishida Shosei、Kangawa Kenji、Sakurai Takashi、Uezono Yasuhito
    • Journal Title

      Endocrine Journal

      Volume: 64 Issue: Suppl. Pages: S35-S39

    • DOI

      10.1507/endocrj.64.s35

      10.1507/endocrj.64.S35

    • NAID

      130007307943

    • ISSN
      0918-8959, 1348-4540
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08243, KAKENHI-PROJECT-16K08507
  • [Journal Article] Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle.2017

    • Author(s)
      Eshima H,Tamura Y, Kakehi S, Kurebayashi N, Murayama T, Nakamura K, Kakigi R,Okada T,Sakurai T, Kawamori R, Watada H
    • Journal Title

      Physiol Rep.

      Volume: 5

    • DOI

      10.14814/phy2.13250

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16J11193, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-15H03097, KAKENHI-PROJECT-15K01729
  • [Journal Article] Extensive Ca2+leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+hypersensitivity2017

    • Author(s)
      Uehara A, Horie M, et al.
    • Journal Title

      The Journal of General Physiology

      Volume: 149 Pages: 199-218

    • DOI

      10.1085/jgp.201611624

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-15K08243, KAKENHI-PROJECT-26460305, KAKENHI-PROJECT-16K08507
  • [Journal Article] Nitric Oxide-induced Activation of the Type 1 Ryanodine Receptor Is Critical for Epileptic Seizure-induced Neuronal Cell Death.2016

    • Author(s)
      Mikami, Y., Kanemaru, K., Okubo, Y., Nakaune, T., Suzuki, J., Shibata, K., Sugiyama, H., Koyama, R., Murayama, T., Ito, A., Yamazawa, T., Ikegaya, Y., Sakurai, T., Saito, N., Kakizawa, S. and Iino, M.
    • Journal Title

      EBioMedicine

      Volume: 11 Pages: 253-261

    • DOI

      10.1016/j.ebiom.2016.08.020

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-25117002, KAKENHI-PROJECT-25221304, KAKENHI-PROJECT-15H05648, KAKENHI-PROJECT-14J12293, KAKENHI-PROJECT-15K06774, KAKENHI-PROJECT-15K08227, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-16K08543
  • [Journal Article] Ultrastructural analysis of self-associated RyR2s.2016

    • Author(s)
      Cabra V, Murayama T, Samso M
    • Journal Title

      Biophysical Journal

      Volume: 110 Pages: 2651-2662

    • DOI

      10.1016/j.bpj.2016.05.013

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Journal Article] Genotype-Phenotype Correlations of Malignant Hyperthermia and Central Core Disease Mutations in the Central Region of the RYR1 Channel.2016

    • Author(s)
      Murayama, T., Kurebayashi, N., Ogawa, H., Yamazawa, T., Oyamada, H., Suzuki, J., Kanemaru, K., Oguchi, K., Iino, M. and Sakurai, T.
    • Journal Title

      Hum Mutat

      Volume: 37 Pages: 1231-1241

    • DOI

      10.1002/humu.23072

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-25117002, KAKENHI-PROJECT-25221304, KAKENHI-PROJECT-15H05648, KAKENHI-PROJECT-25291012, KAKENHI-PROJECT-25650020, KAKENHI-PROJECT-15K08243, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-16H04748
  • [Journal Article] Usefulness of running wheel for detection of congestive heart failure in dilated cardiomyopathy mouse model.2014

    • Author(s)
      Sugihara M, Odagiri F, Suzuki T, Murayama T, Nakazato Y, Unuma K, Yoshida K, Daida H, Sakurai T, Morimoto S, Kurebayashi N.
    • Journal Title

      PLoS One.

      Volume: 8(1)

    • DOI

      10.1371/journal.pone.0055514

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249038, KAKENHI-PROJECT-23300145, KAKENHI-PROJECT-24590330, KAKENHI-PROJECT-24590331, KAKENHI-PROJECT-24790639, KAKENHI-PUBLICLY-25136718, KAKENHI-PUBLICLY-23136514
  • [Journal Article] Mg2+- and ATP-dependent inhibition of transient receptor potential melastatin 7 by oxidative stress.2014

    • Author(s)
      Inoue H, Murayama T, Tashiro M, Sakurai T, Konishi M.
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 72 Pages: 257-266

    • DOI

      10.1016/j.freeradbiomed.2014.04.015

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22110007, KAKENHI-PROJECT-24590330, KAKENHI-PROJECT-25460302
  • [Journal Article] Effects of candesartan on electrical remodeling in the hearts of inherited dilated cardiomyopathy model mice2014

    • Author(s)
      Odagiri, F., H. Inoue, M. Sugihara, T. Suzuki, T. Murayama, T. Shioya, M. Konishi, Y. Nakazato, H. Daida, T. Sakurai, S. Morimoto, N. Kurebayashi
    • Journal Title

      PLoS One

      Volume: 9

    • DOI

      10.1371/journal.pone.0101838

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590331, KAKENHI-PUBLICLY-25136718
  • [Journal Article] Multifunctional GFP Tag2014

    • Author(s)
      Murayama T, Kobayashi T
    • Journal Title

      Methods Mol Biol

      Volume: 1177 Pages: 151-161

    • DOI

      10.1007/978-1-4939-1034-2_12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590330
  • [Journal Article] Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts2013

    • Author(s)
      O-Uchi J, Jhun BS, Hurst S, Bisetto S, Gross P, Chen M, Kettlewell S, Park J, Oyamada H, Smith GL, Murayama T, Sheu SS
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 305

    • DOI

      10.1152/ajpheart.00094.2013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590330
  • [Journal Article] Sperm-Associated Antigen 4, a Novel Hypoxia-Inducible Factor 1 Target, Regulates Cytokinesis, and Its Expression Correlates with the Prognosis of Renal Cell Carcinoma2013

    • Author(s)
      Shoji K, Mimura I, Murayama T, Wada T, Kume H, Goto A, Ohse T, Tanaka T, Inagi R, van der Hoorn FA, Manabe I, Homma Y, Fukayama M, Sakurai T, Hasegawa T, Aburatani H, Kodama T, Nangaku M.
    • Journal Title

      Am J Pathol.

      Volume: 182 Pages: 2191-203

    • DOI

      10.1016/j.ajpath.2013.02.024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J08634, KAKENHI-PROJECT-22590307, KAKENHI-PROJECT-22790781, KAKENHI-PROJECT-24390213, KAKENHI-PROJECT-24590330, KAKENHI-PROJECT-24591189, KAKENHI-PROJECT-25290051, KAKENHI-PROJECT-25460431, KAKENHI-PROJECT-25461207
  • [Journal Article] Mitosis-Coupled, Microtubule-Dependent Clustering of Endosomal Vesicles around Centrosomes2013

    • Author(s)
      Takatsu, H., Katoh, Y., Ueda, T., Waguri, S., Murayama, T., Takahashi, S., Shin, H.-W. &Nakayama, K.
    • Journal Title

      Cell Structure and Function

      Volume: 38 Issue: 1 Pages: 31-41

    • DOI

      10.1247/csf.12028

    • NAID

      130004053889

    • ISSN
      0386-7196, 1347-3700
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390013, KAKENHI-PROJECT-23570162, KAKENHI-PROJECT-24590330, KAKENHI-PUBLICLY-25113514, KAKENHI-PUBLICLY-23113714
  • [Journal Article] 筋小胞体のCa2+放出機構の最近の進歩2012

    • Author(s)
      呉林なごみ, 村山尚
    • Journal Title

      生体の科学

      Volume: 63 Pages: 374-375

    • Data Source
      KAKENHI-PROJECT-24590331
  • [Journal Article] Multistep ion channel remodeling and lethal arrhythmia precede heart failure in a mouse model of inherited dilated cardiomyopathy.2012

    • Author(s)
      Suzuki T, Shioya T, Murayama T, Sugihara M, Odagiri F, Nakazato Y, Nishizawa H, Chugun A, Sakurai T, Daida H, Morimoto S, Kurebayashi N
    • Journal Title

      PLoS One

      Volume: 7

    • DOI

      10.1371/journal.pone.0035353

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590330, KAKENHI-PROJECT-24590331, KAKENHI-PUBLICLY-23136514
  • [Journal Article] Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function.2012

    • Author(s)
      Kakizawa, Sho ; Yamazawa, Toshiko ; Chen, Yili, et al
    • Journal Title

      The EMBO Journal

      Volume: 31(2) Pages: 417-428

    • DOI

      10.1038/emboj.2011.386

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19100005, KAKENHI-PROJECT-21229004, KAKENHI-PROJECT-22300121, KAKENHI-PUBLICLY-23136514, KAKENHI-PROJECT-23300128, KAKENHI-PROJECT-23659037, KAKENHI-PROJECT-24220007, KAKENHI-PROJECT-24590330, KAKENHI-PROJECT-24650200
  • [Journal Article] Two ryanodine receptor isoforms in nonmammalian vertebrate skeletal muscle : Possible roles in excitation-contraction coupling and other processes2011

    • Author(s)
      Murayama T, Kurebayashi N
    • Journal Title

      Prog Biophys Mol Biol

      Volume: 105 Pages: 134-144

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500383
  • [Journal Article] Role of amino-terminal half of the S4-S5 linker in type 1 ryanodme receptor (RyR1) channel gating2011

    • Author(s)
      Takashi Murayama
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 35571-35577

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500383
  • [Journal Article] Simple method of synthesizing nickel-nitrilotriacetic acid gold nanoparticles with a narrow size distribution for protein labeling2011

    • Author(s)
      Kitai T, Watanabe Y, Toyoshima YY, Kobayashi T, Murayama T, Sakaue H, Suzuki H, Takahagi T
    • Journal Title

      Jpn J Appl Phys

      Volume: 50 Pages: 95002-95002

    • NAID

      210000071184

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500383
  • [Journal Article] Two ryanodine receptor isoforms in nonmammalian vertebrate skeletal muscle : Possible roles in excitation-contraction coupliag and other processes2011

    • Author(s)
      Takashi Murayama
    • Journal Title

      Prog Biophys Mol Biol

      Volume: 105 Pages: 134-144

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500383
  • [Journal Article] Two ryanodine receptor isoforms in nonmammalian vertebrate skeletal muscle : Possible roles in excitation-contraction coupling and other processes.2011

    • Author(s)
      Takashi Murayama
    • Journal Title

      Prog Biophys Mol Biol

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500383
  • [Journal Article] Role of amino-terminal half of the S4-S5 linker in type 1 ryanodine receptor(RyR1) channel gating2011

    • Author(s)
      Murayama T, Kurebayashi N, Oba T, Oyamada H, Oguchi K, Sakurai T, Ogawa Y
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 35571-35577

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500383
  • [Journal Article] リアノジン受容体2010

    • Author(s)
      呉林なごみ, 村山尚
    • Journal Title

      生体の科学

      Volume: 61 Pages: 444-445

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500383
  • [Journal Article] Frogα-andβ-ryanodine receptors provide distinct intracellular Ca^<2+> signals in a myogenic cell line2010

    • Author(s)
      Kashiyama T, Murayama T, Suzuki E, Allen PD, Ogawa Y
    • Journal Title

      PLoS ONE

      Volume: 5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500383
  • [Journal Article] Engineering a novel multifunctional green fluorescent protein tag for a wide variety of protein research2008

    • Author(s)
      Kobayashi T, Morone N, Kashiyama T, Oyamada H, Kurebayashi N, Murayama T
    • Journal Title

      PLoS ONE 3

      Pages: 3822-3822

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591009
  • [Journal Article] Postulated role of interdomain interaction between regions 1 and 2 within type 1 ryanodine receptor in the pathogenesis of porcine malignant hyperthermia2007

    • Author(s)
      Murayama, T., Oba, T., Hara, H., Wakebe, K., Ikemoto, N. and Ogawa, Y.
    • Journal Title

      Biochem J 402

      Pages: 349-357

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591009
  • [Journal Article] Postulated role of interdomain interaction between regions I and 2 within type 1 ryanodine receptor in the pathogenesis of porcine malignant hyperthermia.2007

    • Author(s)
      Murayama, T., Oba, T., Hara, H., Wakebe, K., Ikemoto, N., Ogawa, Y
    • Journal Title

      Biochem J 402

      Pages: 349-357

    • Data Source
      KAKENHI-PROJECT-17046019
  • [Journal Article] Malignant hyperthermia mutation sites in the Leu2442-Pro2477 (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area.2007

    • Author(s)
      Bannister, M.L., Hamada, T., Murayama, T., Harvey, P.J., Casarotto, M.G., Dulhunty, A.F., Ikemoto, N.
    • Journal Title

      Biochem J 401

      Pages: 333-339

    • Data Source
      KAKENHI-PROJECT-17046019
  • [Journal Article] Postulated role of interdomain interaction between regions 1 and 2 within type lryanodine receptor in the pathogenesis of porcine malignant hyperthermia2007

    • Author(s)
      Murayama, Takashi
    • Journal Title

      Biochem.J. 402

      Pages: 349-357

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590227
  • [Journal Article] Postulated role of interdomain interaction between regions 1 and 2 within type 1 ryanodine receptor in the pathogenesis of porcine malignant hyperthermia2007

    • Author(s)
      Murayama, T
    • Journal Title

      Biochem J 402

      Pages: 349-357

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590227
  • [Journal Article] Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development2007

    • Author(s)
      Rossi D, Murayama T, Manini I, Franci D, Ogawa Y and Sorrentino V
    • Journal Title

      Cell Calcium 41

      Pages: 573-580

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591009
  • [Journal Article] Synthesis of cyclic ADP-carbocylcic-xylose and its 3"-0-methyl analogue as stable and potent Ca^<2+>-mobilizing agents.2006

    • Author(s)
      Kudoh, T., Matsuda, A., Shuto, S., Murayama, T., Ogawa, Y.
    • Journal Title

      Nucleosides Nucleotides Nucleic Acids 25

      Pages: 583-599

    • Data Source
      KAKENHI-PROJECT-17046019
  • [Journal Article] Postulated role of interdomain interactions within the type 1 ryanodine receptor in the low gain of Ca^<2+>-induced Ca^<2+> release activity of mammalian skeletal muscle sarcoplasmic reticulum2005

    • Author(s)
      Murayama, T
    • Journal Title

      Am J Physiol Cell Physiol 288

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590227
  • [Journal Article] Postulated role of interdomain interactions within the type 1 ryanodine receptor in the low gain of Ca^<2+>-induced Ca^<2+> release activity of mammalian skeletal muscle sarcoplasmic reticulum2005

    • Author(s)
      Murayama, Takashi
    • Journal Title

      Am J Physiol Cell Physiol 228

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590227
  • [Journal Article] Postulated role of interdomain interactions within the type 1 ryanodine receptor in the low gain of Ca^<2+> release activity of mammalian skeletal muscle sarcoplasmic reticulum2005

    • Author(s)
      Murayama, Takashi
    • Journal Title

      American Journal of Physiology, Cell Physiology 288

    • Data Source
      KAKENHI-PROJECT-17590227
  • [Patent] 2型リアノジン受容体活性抑制剤2021

    • Inventor(s)
      國廣なごみ、村山尚、影近弘之、森修一、湯浅磨里、飯沼大翔
    • Industrial Property Rights Holder
      学校法人順天堂、国立大学法人東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19H03404
  • [Patent] 2型リアノジン受容体活性抑制剤2021

    • Inventor(s)
      国広なごみ、村山 尚、影近弘之、森修 一、湯浅磨里、飯沼大翔
    • Industrial Property Rights Holder
      国広なごみ、村山 尚、影近弘之、森修 一、湯浅磨里、飯沼大翔
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19K07105
  • [Patent] 2型リアノジン受容体活性抑制剤2020

    • Inventor(s)
      國廣なごみ、村山尚、影近弘之、森修一、湯浅磨里、飯沼大翔
    • Industrial Property Rights Holder
      学校法人順天堂、国立大学法人東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-020656
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-19H03404
  • [Patent] 2型リアノジン受容体活性抑制剤2020

    • Inventor(s)
      國廣なごみ、村山尚、影近弘之、森 修一、湯浅磨里、飯沼大翔
    • Industrial Property Rights Holder
      学校法人順天堂、国立大学法人東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Patent] 2型リアノジン受容体活性抑制剤2020

    • Inventor(s)
      国広なごみ、村山尚、影近弘之、森修一、湯浅磨里、飯沼大翔
    • Industrial Property Rights Holder
      順天堂大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-020656
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-19K07105
  • [Patent] リアノジン受容体阻害薬2018

    • Inventor(s)
      村山 尚、國廣 なごみ、影近 弘之、森 修一、湯浅 磨里
    • Industrial Property Rights Holder
      村山 尚、國廣 なごみ、影近 弘之、森 修一、湯浅 磨里
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Overseas
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Patent] リアノジン受容体阻害薬2017

    • Inventor(s)
      村山 尚、國廣 なごみ、影近 弘之、森 修一、湯浅 磨里
    • Industrial Property Rights Holder
      学校法人順天堂、国立大学法人東京医科歯科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-205935
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Patent] Ca2+誘発性Ca2+遊離活性抑制剤のスクリーニング方法2016

    • Inventor(s)
      村山 尚、國廣 なごみ
    • Industrial Property Rights Holder
      順天堂大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-113147
    • Filing Date
      2016-06-07
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] RyR2発現細胞におけるCa2+オシレーションと小胞体Ca2+レベルの調節メカニズム2022

    • Author(s)
      呉林 なごみ, 村山 尚, 太田亮 作, 山下 富義, 鈴木 純二, 金丸 和典, 飯野 正光, 櫻井 隆
    • Organizer
      第99回 日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-19K07105
  • [Presentation] DIFFERENTIAL IMPACTS OF ARRHYTHMIA-LINKED LOSS-OF-FUNCTION RYR2 MUTATIONS ON CA2+ SIGNALING IN CARDIAC CELLS.2022

    • Author(s)
      Nagomi Kurebayashi, Takashi Murayama, Naoyuki Tetsuo, Sayako Hirose, Minoru Horie, Seiko Ohno, Takashi Sakurai
    • Organizer
      66th Annual Meeting of the Biophysical Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07105
  • [Presentation] 機能喪失型催不整脈性RyR2変異が引き起こす様々なCa2+動態異常2022

    • Author(s)
      呉林 なごみ,村山 尚,哲翁 直之,廣瀬 紗也子,堀江 稔,大野 聖子,櫻井 隆
    • Organizer
      第95回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K07105
  • [Presentation] CPVTモデルマウスに対するRyR2特異的阻害薬の効果2021

    • Author(s)
      呉林なごみ, 村山尚, 石井光一郎, 小西真人, 杉原匡美, 森修一, 飯沼大翔, 湯浅磨里, 村越伸行, 影近弘之, 櫻井隆
    • Organizer
      第94回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K07105
  • [Presentation] 拡張型心筋症モデルマウスにおける自発運動の効果2021

    • Author(s)
      杉原匡美、柿木亮、村山尚、三井田孝、櫻井隆、森本幸生、呉林なごみ
    • Organizer
      第7回日本筋学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K11246
  • [Presentation] 1型リアノジン受容体チャネル複合体関連筋疾患の発症機構と治療戦略.2021

    • Author(s)
      村山 尚
    • Organizer
      第126回日本解剖学会・第98回日本生理学会合同大会
    • Data Source
      KAKENHI-PROJECT-19H03404
  • [Presentation] 新規1型リアノジン受容体(RyR1)阻害剤の結合部位の同定.2021

    • Author(s)
      村山 尚、呉林 なごみ、小林 琢也、小川 治夫、児玉 昌美、森 修一、影近 弘之、櫻井 隆.
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19H03404
  • [Presentation] 新規1型リアノジン受容体(RyR1)阻害薬の結合部位の探索.2020

    • Author(s)
      村山 尚、呉林 なごみ、小林 琢也、小川 治夫、児玉 昌美、森 修一、影近 弘之、櫻井 隆.
    • Organizer
      第143回日本薬理学会関東部会
    • Data Source
      KAKENHI-PROJECT-19H03404
  • [Presentation] Characterization of novel RyR1-selective inhibitors identified by high-throughput screening using ER Ca2+ measurement.2020

    • Author(s)
      Matsukawa H, Murayama T, Kobayashi T, Kurebayashi N, Yamazawa T, Ishigami-Yuasa M, Mori S, Kagechika H, Sakurai T.
    • Organizer
      Biophysical Society 64th Annual Meeting
    • Data Source
      KAKENHI-PROJECT-19H03404
  • [Presentation] Therapeutic effects of a novel RyR1 inhibitor on malignant hyperthermia model mice.2020

    • Author(s)
      Murayama T, Yamazawa T, Kobayashi T, Kurebayashi N, Noguchi S, Nishino N, Mori S, Kagechika H, Lopez JR, Allen PD, Sakurai T.
    • Organizer
      Biophysical Society 64th Annual Meeting
    • Data Source
      KAKENHI-PROJECT-19H03404
  • [Presentation] 新規RyR1抑制薬の悪性高熱症モデルマウスに対する効果2020

    • Author(s)
      村山 尚,山澤 徳志子,小林 琢也,呉林 なごみ,野口 悟,西野 一三,森 修一,影近 弘之,Jose R. Lopez,Paul D. Allen,櫻井 隆
    • Organizer
      第93回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] 新規RyR1抑制薬の悪性高熱症モデルマウスに対する効果.2020

    • Author(s)
      村山 尚,山澤 徳志子,小林 琢也,呉林 なごみ,野口 悟,西野 一三,森 修一,影近 弘之,Jose R. Lopez,Paul D. Allen,櫻井 隆.
    • Organizer
      第93回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19H03404
  • [Presentation] 小胞体内Ca2+濃度測定により新たに同定されたRyR1選択的阻害剤の性質の検討.2020

    • Author(s)
      松川 紘之、村山 尚、小林 琢也、呉林 なごみ、山澤 徳志子、湯浅 磨里、森 修一、影近 弘之、櫻井 隆.
    • Organizer
      第6回日本筋学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H03404
  • [Presentation] Therapeutic effects of a novel RyR1 inhibitor on malignant hyperthermia model mice2020

    • Author(s)
      Murayama T, Yamazawa T, Kobayashi T, Kurebayashi N, Noguchi S, Nishino N, Mori S, Kagechika H, Lopez JR, Allen PD, Sakurai T
    • Organizer
      Biophysical Society 64th Annual Meeting
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] Effects of novel RyR2 inhibitors on cardiac myocytes from diseased hearts2020

    • Author(s)
      Nagomi Kurebayashi, Takashi Murayama, Masato Konishi, Shuichi Mori, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Haruo Ogawa, Sachio Morimoto, Takashi Sakurai
    • Organizer
      63th Annual Meeting of the Biophysical Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07105
  • [Presentation] The NH2-terminal region is the key for the differential drug sensitivity of TRPM7 and TRPM62020

    • Author(s)
      Hana Inoue, Takashi Murayama, Takuya Kobayashi, Ryo Mizumoto, Utako Yokoyama
    • Organizer
      The 97th Annual Meeting of the Physiological Society of Japan
    • Data Source
      KAKENHI-PROJECT-17K08549
  • [Presentation] Molecular mechanisms of TRPM7 inhibition by oxidative stress2019

    • Author(s)
      Hana Inoue, Takashi Murayama, Masato Konishi, Michiko Tashiro, Utako Yokoyama
    • Organizer
      The 50 th NIPS International Symposium MIRACLES in Cardiovascular Physiology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08549
  • [Presentation] リアノジン受容体チャネル制御機構への構造・機能学的アプローチ2019

    • Author(s)
      村山 尚
    • Organizer
      第92回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] 悪性高熱症モデルマウスを用いた新規RyR1阻害薬の治療効果の検討2019

    • Author(s)
      村山 尚、山澤 徳志子、小林 琢也、呉林 なごみ、野口 悟、井上 高良、井上 由紀子、森 修一、飯沼 大翔、間中 紀暁、湯浅 磨里、影近 弘之、西野 一三、櫻井 隆
    • Organizer
      第5回日本筋学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] リアノジン受容体チャネル制御機構への構造・機能学的アプローチ.2019

    • Author(s)
      村山 尚
    • Organizer
      第92回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-19H03404
  • [Presentation] Regulation of TRPM7 channel activity by its kinase domain2019

    • Author(s)
      Hana Inoue, Takashi Murayama, Takuya Kobayashi, Masato Konishi
    • Organizer
      9th FAOPS
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08549
  • [Presentation] 1.Molecular dynamics and Ca2+ imaging of mutant type 1 ryanodine receptors.2019

    • Author(s)
      Yamazawa T, Ogawa H, Murayama T, Yamaguchi M, Oyamada H, Suzuki J, Kurebayashi N, Kanemaru K, Oguchi K, Sakurai T, Iino M
    • Organizer
      Gordon Research Conference  Muscle: Excitation-Contraction Coupling
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07306
  • [Presentation] 悪性高熱症モデルマウスを用いた新規RyR1阻害薬の治療効果の検討.2019

    • Author(s)
      村山 尚、山澤 徳志子、小林 琢也、呉林 なごみ、野口 悟、井上 高良、井上 由紀子、森 修一、飯沼 大翔、間中 紀暁、湯浅 磨里、影近 弘之、西野 一三、櫻井 隆.
    • Organizer
      第5回日本筋学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H03404
  • [Presentation] Identification of novel inhibitors of Ca2+-induced Ca2+ release for RyR1-related muscle diseases2019

    • Author(s)
      Takashi Murayama
    • Organizer
      9th FAOPS Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] Molecular basis of Ca2+ binding to the ryanodine receptor for channel activation2018

    • Author(s)
      Murayama T, Ogawa H, Kurebayashi N, Ohno S, Horie M, Sakurai T
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] Screening of oxidative stress sensors in TRPM7 channel2018

    • Author(s)
      Hana Inoue, Takashi Murayama, Masato Konishi
    • Organizer
      日本生理学会
    • Data Source
      KAKENHI-PROJECT-17K08549
  • [Presentation] 小胞体内Ca2+濃度測定によるリアノジン受容体阻害薬探索システムの開発2018

    • Author(s)
      村山 尚、呉林 なごみ、湯浅(石上) 磨里、森 修一、鈴木 志奈、秋間 龍之介、小川 治夫、鈴木 純二、金丸 和典、小山田 英人、木内 祐二、飯野 正光、影近 弘之、櫻井 隆
    • Organizer
      第139回日本薬理学会関東部会
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] 小胞体内Ca2+濃度測定による新規RyR1阻害薬のハイスループットスクリーニング2018

    • Author(s)
      村山 尚、呉林 なごみ、湯浅(石上) 磨里、森 修一、鈴木 志奈、秋間 龍之介、小川 治夫、鈴木 純二、金丸 和典、小山田 英人、木内 祐二、飯野 正光、影近 弘之、櫻井 隆
    • Organizer
      第4回日本筋学会
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] 酸化ストレスによるTRPM7活性制御メカニズムの解明2018

    • Author(s)
      Hana Inoue, Takashi Murayama, Masato Konishi
    • Organizer
      第3回イオンチャネル研究会
    • Data Source
      KAKENHI-PROJECT-17K08549
  • [Presentation] Molecular basis for Ca2+ and caffeine action on the RyR2 channel and implications in disease states2017

    • Author(s)
      Takashi Murayama, Haruo Ogawa, Nagomi Kurebayashi, Takashi Sakurai
    • Organizer
      20th International Symposium on Calcium Binding Proteins and Calcium Function in Health and Disease (CaBP20)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] 1型リアノジン受容体(RYR1)チャネルC末端領域セントラルコア病変異の遺伝子型-表現型相関2017

    • Author(s)
      村山 尚、呉林なごみ、小川治夫、山澤徳志子、小山田英人、小口勝司、櫻井 隆
    • Organizer
      第90回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] Genotype-phenotype correlations of central core disease mutations in the C-terminal region of the RYR1 channel2017

    • Author(s)
      Takashi Murayama, Nagomi Kurebayashi, Haruo Ogawa, Toshiko Yamazawa, Takashi Sakurai
    • Organizer
      Biophysical Society 61st Annual Meeting
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] 酸化ストレスによるTRPM7活性制御機構の解明2017

    • Author(s)
      Hana Inoue, Takashi Murayama, Masato Konishi
    • Organizer
      東京談話会
    • Data Source
      KAKENHI-PROJECT-17K08549
  • [Presentation] RyR1関連筋疾患の分子機構:診断と治療に向けて2017

    • Author(s)
      村山 尚
    • Organizer
      第94回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] リアノジン受容体関連疾患の分子機構:診断と治療に向けて2017

    • Author(s)
      村山 尚
    • Organizer
      第3回日本筋学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] Molecular mechanism of type 1 ryanodine receptor-related muscle diseases: toward diagnosis and therapy2017

    • Author(s)
      Takashi Murayama
    • Organizer
      AuPS Scientific Meeting
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] 1型リアノジン受容体C末端領域疾患変異体の機能解析2016

    • Author(s)
      村山 尚、呉林なごみ、山澤徳志子、小川治夫、小山田英人、小口勝司、櫻井 隆
    • Organizer
      第2回日本筋学会学術集会
    • Place of Presentation
      小平
    • Year and Date
      2016-08-05
    • Data Source
      KAKENHI-PROJECT-16K08507
  • [Presentation] 2型リアノジン受容体の不整脈原性変異はCICR活性とCa2+ 動態にどのような影響を及ぼすか?2015

    • Author(s)
      呉林なごみ, 村山尚, 太田亮作, 山下富義, 鈴木純二, 金丸和典, 飯野正光, 櫻井隆
    • Organizer
      第88回 日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-19
    • Data Source
      KAKENHI-PROJECT-24590331
  • [Presentation] 2型リアノジン受容体の不整脈原性変異はCICR活性とCa2+動態にどのような影響を及ぼすか?2015

    • Author(s)
      呉林なごみ, 村山 尚, 太田亮作, 山下富義, 鈴木純二, 金丸和典, 飯野正光, 櫻井 隆
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-19
    • Data Source
      KAKENHI-PROJECT-24590330
  • [Presentation] Effects of MH and CCD mutations in the central region on RyR1 channels.2015

    • Author(s)
      Takashi Murayama, Nagomi Kurebayashi, Toshiko Yamazawa, Hideto Oyamada, Junji Suzuki, Kazunori Kanemaru, Katsuji Oguchi, Masamitsu Iino, and Takashi Sakurai
    • Organizer
      Biophysical Society 59th Annual Meeting
    • Place of Presentation
      ボルチモア、アメリカ合衆国
    • Year and Date
      2015-02-09
    • Data Source
      KAKENHI-PROJECT-24590331
  • [Presentation] 1型リアノジン受容体チャネルに対する中央領域疾患変異の効果2015

    • Author(s)
      村山 尚、呉林なごみ、山澤徳志子、小山田英人、鈴木純二、金丸和典、小口勝司、飯野正光、櫻井 隆
    • Organizer
      第120回日本解剖学会総会全国学術集会・第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-22
    • Data Source
      KAKENHI-PROJECT-24590330
  • [Presentation] Effects of arrhythmogenic mutations on Ca2+-induced Ca2+ release activities of type 2 ryanodine receptors.2015

    • Author(s)
      Kurebayashi, N., T. Murayama, J. Suzuki, K. Kanemaru, M. Iino, T. Sakurai
    • Organizer
      Biophysical society, 59th Annual Meeting
    • Place of Presentation
      Baltimore
    • Year and Date
      2015-02-11
    • Data Source
      KAKENHI-PROJECT-24590330
  • [Presentation] Effects of arrhythmogenic mutations on Ca2+-induced Ca2+ release activities of type 2 ryanodine receptors.2015

    • Author(s)
      Kurebayashi, N., T. Murayama, J. Suzuki, K. Kanemaru, M. Iino, T. Sakurai
    • Organizer
      Biophysical society, 59th Annual Meeting
    • Place of Presentation
      ボルチモア、アメリカ合衆国
    • Year and Date
      2015-02-11
    • Data Source
      KAKENHI-PROJECT-24590331
  • [Presentation] 1型リアノジン受容体チャネル活性に対する中央領域疾患変異の効果2015

    • Author(s)
      村山 尚、呉林なごみ、山澤徳志子、小山田英人、鈴木純二、金丸和典、小口勝司、飯野正光、櫻井 隆
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-20
    • Data Source
      KAKENHI-PROJECT-24590330
  • [Presentation] Effects of MH and CCD mutations in the central region on RyR1 channels.2015

    • Author(s)
      Takashi Murayama, Nagomi Kurebayashi, Toshiko Yamazawa, Hideto Oyamada, Junji Suzuki, Kazunori Kanemaru, Katsuji Oguchi, Masamitsu Iino, and Takashi Sakurai
    • Organizer
      Biophysical Society 59th Annual Meeting
    • Place of Presentation
      Baltimore
    • Year and Date
      2015-02-09
    • Data Source
      KAKENHI-PROJECT-24590330
  • [Presentation] Divergent effects of disease associated mutations on type 2 ryanodine receptor channel.2014

    • Author(s)
      Kurebayashi, N Murayama, T Uehara, A Yasukochi, M Sakura,i T
    • Organizer
      58th Biophysical Society Annual Meeting
    • Place of Presentation
      サンフランシスコ、米国
    • Data Source
      KAKENHI-PROJECT-24590331
  • [Presentation] 不整脈原性2型リアノジン受容体のCICR特性2014

    • Author(s)
      呉林なごみ 村山尚 鈴木純二 金丸和典 飯野正光 櫻井隆
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-24590331
  • [Presentation] Effects of candesartan on progression of electrical remodeling in the hearts of inherited DCM model mice2014

    • Author(s)
      Nagomi Kurebayashi, Fiminori Odagiri, Hana Inoue, Masami Sugihara, Takeshi Suzuki, Takashi Murayama, Takao Shioya, Masato Konishi, Yuji Nakazato, Hiroyuki Daida, Takashi Sakurai, Sachio Morimoto,
    • Organizer
      17th World Congress of Pharmacology
    • Place of Presentation
      ケープタウン、南アフリカ共和国
    • Data Source
      KAKENHI-PROJECT-24590331
  • [Presentation] 心筋型リアノジン受容体(RyR2)不整脈原性変異のCa2+ 動態とCICR活性に対する効果2014

    • Author(s)
      呉林なごみ, 村山尚, 太田亮作, 山下富義, 鈴木純二, 金丸和典, 飯野正光, 櫻井隆
    • Organizer
      第24回 日本循環薬理学会
    • Place of Presentation
      山形テルサ、山形市
    • Year and Date
      2014-12-05
    • Data Source
      KAKENHI-PROJECT-24590331
  • [Presentation] 心室性不整脈を誘発する2型リアノジン受容体変異体のCa2+遊離の特性2014

    • Author(s)
      呉林なごみ 村山尚 鈴木純二 金丸和典 飯野正光 櫻井隆
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Data Source
      KAKENHI-PROJECT-24590331
  • [Presentation] 拡張型心筋症モデルマウス心臓の電気的リモデリングに対するカンデサルタンの効果2013

    • Author(s)
      呉林なごみ, 小田切史徳, 杉原匡美, 鈴木剛, 井上華, 村山尚, 塩谷孝雄, 小西真人, 中里祐二, 代田浩之, 櫻井隆, 森本幸生
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24590331
  • [Presentation] FFECTS OF ANGIOTENSIN II RECEPTOR BLOCKER ON THE PROGRESSION OF ELECTRICAL REMODELING IN HEARTS OF INHERITED DCM MODEL MICE.2013

    • Author(s)
      Odagiri F, Inoue H, Sugihara M, Suzuki T, Murayama T, Shioya T, Konishi M, Nakazato Y, Daida H, Sakurai T, Morimoto S, Kurebayashi N
    • Organizer
      57th Biophysical Society Annual Meeting Philadelphia
    • Place of Presentation
      フィラデルフィア
    • Data Source
      KAKENHI-PROJECT-24590331
  • [Presentation] Role of amino-terminal half of the S4-S5 linker in the RyR1 channel gating2012

    • Author(s)
      Murayama T, Kurebayashi N, Oba T, Oyamada H, Oguchi K, Sakurai T, Ogawa Y
    • Organizer
      Biophysical Society 56th Annual Meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2012-02-27
    • Data Source
      KAKENHI-PROJECT-21500383
  • [Presentation] 1型リアノジン受容体S4-S5リンカーはチャネルゲーティングを調節する2012

    • Author(s)
      村山尚、呉林なごみ、大羽利治、小山田英人、小口勝司、小川靖男、櫻井隆
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
    • Data Source
      KAKENHI-PROJECT-21500383
  • [Presentation] Ryanodine receptor isoforms in excitation-contraction coupling in skeletal muscle2009

    • Author(s)
      Murayama T
    • Organizer
      36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-29
    • Data Source
      KAKENHI-PROJECT-21500383
  • [Presentation] Ryanodine receptor isoforms in excitation-contraction coupling in skeletal muscle2009

    • Author(s)
      Takashi Murayama
    • Organizer
      36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2009-07-29
    • Data Source
      KAKENHI-PROJECT-21500383
  • [Presentation] 新規多機能GFPを用いたリアノジン受容体の構造機能解析2009

    • Author(s)
      村山尚, 小林琢也, 樫山拓, 呉林なごみ, 木森義隆, 諸根信弘, 北井敏幸, 高萩隆行, 櫻井隆
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-17
    • Data Source
      KAKENHI-PROJECT-21500383
  • [Presentation] Generation of the GFP-tagged Type 1 Ryanodine Receptor Mutants by Transposon-based Random Insertion Approach2008

    • Author(s)
      Murayama, Takashi
    • Organizer
      Biophysical Society 52nd Annual Meeting
    • Place of Presentation
      Long Beach,CA.
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590227
  • [Presentation] トランスポゾンを用いたリアノジン受容体/Ca^<2+>遊離チャネルの構造機能解析2008

    • Author(s)
      村山 尚
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590227
  • [Presentation] トランスポゾンランダム挿入法を用いた蛍光性RyRlチャネルの作製2008

    • Author(s)
      村山 尚
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590227
  • [Presentation] Generation of the GFP-tagged type 1 ryanodine receptor mutants by transposon-based random insertion approach2008

    • Author(s)
      Murayama, T, Kashiyama, T, Oyamada, H, Kobayashi, T, Kurebayashi, N, Sakurai, T
    • Organizer
      Biophysical Society 52nd Annual Meeting
    • Place of Presentation
      Long Beach, CA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590227
  • [Presentation] Role of cytoplasmic loop between M7b and M8 transmembrane hilices of RyR1 in Ca^<2+> channel activity2007

    • Author(s)
      Murayama, Takashi
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590241
  • [Presentation] Role of a cytoplasmic loop between M7b and M8 transmembrane hilices of RyR1 in Ca^<2+> release channel gating2007

    • Author(s)
      Murayama, Takashi
    • Organizer
      Biophys J : 90a
    • Place of Presentation
      Biophysical Society 51st Annual Meeting, Baltimore, MD, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590241
  • [Presentation] Role of a cytoplasmic loop between M7b and M8 transmembrane hilices of RyR1 in Ca^<2+> release channel gating2007

    • Author(s)
      Murayama, Takashi
    • Organizer
      Biophysical Society 51st Annual Meeting
    • Place of Presentation
      Baltimore,MD,USA
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590241
  • [Presentation] 悪性高熱における1型リアノジン受容体ドメイン問相互作用の関与2007

    • Author(s)
      村山 尚
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590227
  • [Presentation] Role of a cytoplasmic loop between M7b and M8 transmembrane helices of RyR1 in Ca^<2+> channel gating2007

    • Author(s)
      Murayama, T, Oyamada, H, Oba, T, Oguchi, K, Kurebayashi, N
    • Organizer
      Biophysical Society 51st Annual Meeting
    • Place of Presentation
      Baltimore, MD
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590227
  • [Presentation] Role of cytoplasmic loop between M7b and M8 transmembrane hilices of RyR1 in Ca^<2+> channel activity2007

    • Author(s)
      Murayama, Takashi
    • Organizer
      JPharmacol Sci 103 Supplement I : 110P
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590241
  • [Presentation] Role of a cytoplasmic loop between M7b and M8 transmembrane helices of RyRl in Ca^<2+>channel gating2007

    • Author(s)
      Murayama, Takashi
    • Organizer
      Biophysical Society 51st Annual Meeting
    • Place of Presentation
      Baltimore,MD.
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590227
  • [Presentation] 悪性高熱症における1型リアノジン受容体ドメイン間相互作用の関与2006

    • Author(s)
      村山 尚
    • Organizer
      第83回日本生理学会大会
    • Place of Presentation
      前橋
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590227
  • [Presentation] Postulated role of interdomain interactions within the type 1 ryanodine receptor in dysfunction of Ca^<2+>release channel in malignant hyperthermia2006

    • Author(s)
      Murayama, Takashi
    • Organizer
      Biophysical Society 50th Annual Meeting
    • Place of Presentation
      Salt Laky City,UT.
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590227
  • [Presentation] 1型リアノジン受容体ドメイン間相互作用の低下は悪性高熱症における充進したCa^<2+>遊離を引き起こす2006

    • Author(s)
      村山 尚
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590227
  • [Presentation] Postulated role of interdomain interactions within the type 1 ryanodine receptor in dysfunction of Ca^<2+> release channel in malignant hyperthermia2006

    • Author(s)
      Murayama, T, Oyamada, H, Kurebayashi, N, Oba, T, Hara, H, Wakebe, K, Ikemoto, N, Ogawa, Y
    • Organizer
      Biophysical Society 50th Annual Meeting
    • Place of Presentation
      Salt Laky City, UT
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590227
  • [Presentation] C末端悪性高熱変異を有する1型リアノジン受容体チャネルの機能解析

    • Author(s)
      村山 尚、青木良輔、赤塚祐介、呉林なごみ、小山田英人、小口勝司、櫻井 隆
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      船堀
    • Data Source
      KAKENHI-PROJECT-24590330
  • [Presentation] 1型リアノジン受容体チャネルに対する疾患変異の多様な効果

    • Author(s)
      村山 尚、呉林なごみ、小山田英人、鈴木純二、金丸和典、小口勝司、飯野正光、櫻井 隆
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24590330
  • 1.  KUREBAYASHI Nagomi (50133335)
    # of Collaborated Projects: 10 results
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  • 4.  小林 琢也 (60468585)
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  • 5.  HIRASAWA Eri (50245718)
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  • 6.  NAKAZATO Yuji (30266035)
    # of Collaborated Projects: 2 results
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  • 32.  TANAKA Tetsuhiro
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  • 35.  OHSE Takamoto
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  • 38.  KANEMARU Kazunori
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  • 39.  OKUBO yohei
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  • 40.  FUJIMURA Tsutomu
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  • 41.  HANASHIMA Akira
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  • 42.  UJIHARA Yoshihiro
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  • 43.  INOUE Yukiko
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  • 44.  MAKIYAMA Takeru
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  • 45.  TAMURA Yoshihumi
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  • 46.  UEHARA Kiyoko
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  • 47.  国広 なごみ
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  • 48.  堀米 仁志
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  • 49.  野崎 良寛
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  • 50.  村山 繁雄
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  • 51.  大野 聖子
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  • 52.  吉田 謙一
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  • 53.  鵜沼 香奈
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  • 54.  桜井 正樹
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  • 56.  竹島 美幸
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  • 57.  竹島 浩
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  • 83.  河盛 隆造
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 84.  山口 啓介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 85.  井関 雅子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 86.  野中 美希
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 87.  宮野 加奈子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 88.  上園 保仁
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 89.  森 望
    # of Collaborated Projects: 0 results
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