Kakigi Ryo 柿木亮

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KAKIGI RYO 柿木亮

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Researcher Number	70614931
Other IDs
Affiliation (Current)	2025: 城西国際大学, 経営情報学部, 准教授 2025: 順天堂大学, スポーツ健康科学部, 非常勤助教
Affiliation (based on the past Project Information) *help	2024: 城西国際大学, 経営情報学部, 准教授 2019 – 2024: 順天堂大学, スポーツ健康科学部, 非常勤助教 2016 – 2018: 順天堂大学, 医学部, 助教 2012 – 2014: 順天堂大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 59020:Sports sciences-related / Sports science / Sports science Except Principal Investigator Basic Section 59010:Rehabilitation science-related / Basic Section 59020:Sports sciences-related / Applied health science / Eating habits / Integrated Nutrition Science
Keywords	Principal Investigator 骨格筋 / 筋萎縮 / サルコペニア / 筋タンパク質合成 / タンパク質合成 / 筋肥大 / 細胞内シグナル伝達 / 性差 / 運動適応 / 筋サテライト細胞 … More / 運動処方 / 筋力低下 / トレーニング / 筋量 / 筋張力 / ビタミンD / タンパク質合成・分解 / タンパク質分解 / ロイシン / 分化・融合 / C2C12 / ラパマイシン / 熱ストレス / 温熱負荷 / トレーニングステータス / 筋線維タイプ / レジスタンス運動 / 筋線維組成 / 筋収縮様式 … More Except Principal Investigator 心不全 / 心室性不整脈 / 拡張型心筋症 / 運動療法 / 筋萎縮 / サルコペニア / 骨格筋 / 骨格筋萎縮 / トレーナビリティ / アンジオテンシンII1型受容体 / 運動適応 / アンジオテンシンII受容体 / 性差 / 不整脈 / レニン・アンギオテンシン阻害薬 / 高脂肪食 / 糖代謝 / 老齢 / JNK / 加齢 / 肥満 / サルコペニア肥満 / 温熱刺激 / 血管トーヌス / 高血圧症 / マグネシウム欠乏症 / 血管平滑筋 / 血管収縮 / 高血圧 / マグネシウム欠乏 / 虚血-再灌流障害 / 一酸化窒素合成酵素 / フコイダン / 血管弛緩反応 / 一酸化窒素 / 血管内皮細胞 Less

家族性拡張型心筋症モデルにおける運動療法の効果
- Principal Investigator
  
  杉原匡美
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Juntendo University
筋サテライト細胞の活性化を基盤としたヒト骨格筋適応メカニズムの性差の解明Principal Investigator
- Principal Investigator
  
  柿木亮
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Josai International University
The construction of exercise therapy in familial DCM model mice
- Principal Investigator
  
  杉原匡美
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Juntendo University
骨格筋適応の性差を司るアンジオテンシン受容体制御機構の解明
- Principal Investigator
  
  吉原利典
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Juntendo University
ビタミンD不足はサルコペニア進行の増悪因子なのか？Principal Investigator
- Principal Investigator
  
  柿木亮
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Juntendo University
Elucidation of physiological mechanism(s) of magnesium deficiency-induced hypertension
- Principal Investigator
  
  IESAKI TAKAFUMI
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Juntendo University
Mechanisms underlying heat stress-induced skeletal muscle adaptation in prevention of sarcopeniaPrincipal Investigator
- Principal Investigator
  
  Kakigi Ryo
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Sports science
- Research Institution
  Juntendo University
Effect of heat stress on body fat mass and muscle mass in mice with sarcopenia obesity
- Principal Investigator
  
  Goto Ayumi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Applied health science
- Research Institution
  Juntendo University
Investigation of the mechanism of nitric oxide production by an extract of brown marine algae and its usefulness as a functional food
- Principal Investigator
  
  Iesaki Takafumi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Juntendo University
Effect of muscle contraction mode on intracellular signaling-related muscle hypertrophyPrincipal Investigator
- Principal Investigator
  
  KAKIGI RYO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Sports science
- Research Institution
  Juntendo University

All 2023 2022 2021 2020 2019 2018 2017 2016 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles2022
- Author(s)
  Chang Shuo-wen、Yoshihara Toshinori、Tsuzuki Takamasa、Natsume Toshiharu、Kakigi Ryo、Machida Shuichi、Naito Hisashi
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 2 Pages: e0264171-e0264171
- DOI
  10.1371/journal.pone.0264171
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11526, KAKENHI-PROJECT-19K22820, KAKENHI-PROJECT-23K21588
[Journal Article] Long-term physical inactivity exacerbates hindlimb unloading-induced muscle atrophy in young rat soleus muscle2021
- Author(s)
  Yoshihara Toshinori、Natsume Toshiharu、Tsuzuki Takamasa、Chang Shuo-Wen、Kakigi Ryo、Machida Shuichi、Sugiura Takao、Naito Hisashi
- Journal Title
  
  Journal of Applied Physiology
  
  Volume: 130 Issue: 4 Pages: 1214-1225
- DOI
  10.1152/japplphysiol.00494.2020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11526, KAKENHI-PROJECT-19K22820, KAKENHI-PROJECT-21K19735
[Journal Article] Maintenance of contractile force and increased fatigue resistance in slow-twitch skeletal muscle of mice fed a high-fat diet2021
- Author(s)
  Eshima Hiroaki、Tamura Yoshifumi、Kakehi Saori、Kakigi Ryo、Kawamori Ryuzo、Watada Hirotaka
- Journal Title
  
  Journal of Applied Physiology
  
  Volume: 130 Issue: 3 Pages: 528-536
- DOI
  10.1152/japplphysiol.00218.2020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11526, KAKENHI-PROJECT-21K11684
[Journal Article] Age-related changes in histone modification in rat gastrocnemius muscle.2019
- Author(s)
  Yoshihara T, Machida S, Tsuzuki T, Kakigi R, Chang SW, Sugiura T, Naito H.
- Journal Title
  
  Exp Gerontol.
  
  Volume: 125 Pages: 110658-110658
- DOI
  10.1016/j.exger.2019.110658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01765, KAKENHI-PROJECT-19K11526, KAKENHI-PROJECT-16H03205
[Journal Article] Sex-specific differences in rat soleus-muscle signaling pathway responses to a bout of horizontal and downhill running.2019
- Author(s)
  Yoshihara T, Chang SW, Tsuzuki T, Natsume T, Kakigi R, Sugiura T, Naito H.
- Journal Title
  
  J Physiol Biochem.
  
  Volume: 75(4) Issue: 4 Pages: 585-595
- DOI
  10.1007/s13105-019-00712-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01765, KAKENHI-PROJECT-16K16565
[Journal Article] Effect of a combination of astaxanthin supplementation, heat stress, and intermittent reloading on satellite cells during disuse muscle atrophy2018
- Author(s)
  Toshinori Yoshihara, Takao Sugiura, Nobuyuki Miyaji, Yuki Yamamoto, Tsubasa Shibaguchi, Ryo Kakigi, Hisashi Naito, Katsumasa Goto, Daijiro Ohmori, Toshitada Yoshioka
- Journal Title
  
  Journal of Zhejiang University SCIENCE B
  
  Volume: N/A Issue: 11 Pages: 844-852
- DOI
  10.1631/jzus.b1800076
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01765, KAKENHI-PROJECT-17K01762, KAKENHI-PROJECT-16K16565, KAKENHI-PROJECT-18H03160
[Journal Article] Body temperature elevation during exercise is essential for activating the Akt signaling pathway in the skeletal muscle of type 2 diabetic rats2018
- Author(s)
  Tsuzuki Takamasa、Yoshihara Toshinori、Ichinoseki-Sekine Noriko、Kakigi Ryo、Takamine Yuri、Kobayashi Hiroyuki、Naito Hisashi
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 10 Pages: e0205456-e0205456
- DOI
  10.1371/journal.pone.0205456
- NAID
  120007133689
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K16565
[Journal Article] Heat stress-induced phosphorylation of FoxO3a signalling in rat skeletal muscle.2016
- Author(s)
  Yoshihara T, Kobayashi H, Kakigi R, Sugiura T, Naito H.
- Journal Title
  
  Acta Physiol (Oxf)
  
  Volume: 218(3) Issue: 3 Pages: 178-187
- DOI
  10.1111/apha.12735
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26506021, KAKENHI-PROJECT-16K16565
[Journal Article] Whey protein intake after resistance exercise activates mTOR signaling in a dose-dependent manner in human skeletal muscle2014
- Author(s)
  Kakigi R, Yoshihara T, Ozaki H, Ogura Y, Ichinoseki-Sekine N, Kobayashi H, Naito H
- Journal Title
  
  European Journal of Applied Physiolgy
  
  Volume: 114 Issue: 4 Pages: 735-742
- DOI
  10.1007/s00421-013-2812-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J10802, KAKENHI-PROJECT-24700703
[Journal Article] Effects of walking combined with restricted leg blood flow on mTOR and MAPK signaling in young men2014
- Author(s)
  Ozaki H, Kakigi R, Kobayashi H, Loenneke JP, Abe T, Naito H
- Journal Title
  
  Acta Physiologica
  
  Volume: (印刷中) Issue: 1 Pages: 97-106
- DOI
  10.1111/apha.12243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J10802, KAKENHI-PROJECT-24700703
[Presentation] 拡張型心筋症モデルマウスにおける自発運動の頻度と詳細2023
- Author(s)
  杉原匡美、柿木亮、村山尚、三井田孝、櫻井隆、森本幸生、呉林なごみ
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-21K11246
[Presentation] EFFECTS OF VOLUNTARY EXERCISE AND ADMINISTRATION OF RENIN ANGIOTENSIN INHIBITOR ON CARDIAC FUNCTION IN INHERITED DILATED CARDIOMYOPATHY MODEL2023
- Author(s)
  Masami Sugihara,Ryo Kakigi,Takashi Murayam,Takashi Miida,Takashi Sakura,,Sachio Morimoto,Nagomi Kurebayashi
- Organizer
  第67回米国生物物理学会
- Data Source
  KAKENHI-PROJECT-21K11246
[Presentation] 拡張型心筋症モデルマウスにおける自発運動とレニン・アンギオテンシン阻害剤投与の比較2022
- Author(s)
  杉原匡美、柿木亮、村山尚、櫻井隆、三井田孝、森本幸生、呉林なごみ
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K11246
[Presentation] ビタミンD欠乏食摂取がマウス足底筋の張力発揮や疲労耐性に及ぼす影響2022
- Author(s)
  柿木亮, 吉原利典, 内藤久士
- Organizer
  第77回日本体力医学会
- Data Source
  KAKENHI-PROJECT-19K11526
[Presentation] 拡張型心筋症モデルマウスにおける自発運動の効果2021
- Author(s)
  杉原匡美、柿木亮、村山尚、三井田孝、櫻井隆、森本幸生、呉林なごみ
- Organizer
  第7回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-21K11246
[Presentation] ラットの廃用性筋萎縮に対するFoxO3aシグナル伝達応答における性差2020
- Author(s)
  吉原利典, 棗寿喜，都築孝允，張碩文, 柿木亮，町田修一, 杉浦崇夫, 内藤久士
- Organizer
  第75回体力医学会大会
- Data Source
  KAKENHI-PROJECT-23K20366
[Presentation] High-fat diet augments muscle atrophy by changes of muscle atrophy-related genes in mice2018
- Author(s)
  Goto A, Tsuzuki T, Yoshihara T, Furuichi S, Tsukioka K, Kakigi R, Naito H
- Organizer
  Experimental Biology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07182
[Presentation] 温熱刺激はサルコペニア肥満の新規治療法となり得るか？2018
- Author(s)
  後藤亜由美, 柿木亮, 吉原利典, 松本綾子, 都築孝允, 古市真也, 月岡恵惟, 内藤久士
- Organizer
  第26回日本物理療法学会学術大会
- Data Source
  KAKENHI-PROJECT-16K16565
[Presentation] Effects of heat stress treatment and leucine supplementation on age-related muscle loss in mice2018
- Author(s)
  Kakigi R, Goto A, Yoshihara T, Tsuzuki T, Naito H
- Organizer
  Experimental Biology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16565
[Presentation] Acute heat stress under fed state stimulates muscle protein synthesis in mouse soleus muscle2018
- Author(s)
  Kakigi R, Yoshihara T, Goto A, Naito H
- Organizer
  2018 ACSM conference on integrative physiology of exercise
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16565
[Presentation] Effects of heat stress treatment and leucine supplementation on agerelated muscle loss in mice.2018
- Author(s)
  Kakigi R, Goto A, Yoshihara T, Tsuzuki T, Naito H
- Organizer
  Experimental Biology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07182
[Presentation] 肥満が廃用性筋萎縮に伴う筋萎縮関連遺伝子の発現に及ぼす影響2017
- Author(s)
  後藤亜由美、都築孝允、吉原利典、柿木亮、古市真也、月岡惠惟、内藤久士
- Organizer
  第72回日本体力医学会大会
- Data Source
  KAKENHI-PROJECT-16H07182
[Presentation] Effects of a bout of downhill running on skeletal muscle function and Ca2+ handling in mouse extensor digitorum longus muscle2017
- Author(s)
  Kakigi R, Nakamura K, Eshima H, Yoshihara T, Naito H
- Organizer
  The 3rd congress, International Academy of Sportology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16565
[Presentation] 温熱刺激とロイシン摂取の組み合わせが高齢マウスの筋量および筋機能に及ぼす影響2017
- Author(s)
  柿木亮、後藤亜由美、吉原利典、都築孝允、内藤久士
- Organizer
  第72回日本体力医学会大会
- Data Source
  KAKENHI-PROJECT-16H07182
[Presentation] Effect of acute immobilization on the expression levels of atrophy-related ubiquitin ligase in mice fed a high-fat diet.2017
- Author(s)
  Goto A, Tsuzuki T, Yoshihara T, Furuichi S, Tsukioka K, Zhi L, Kakigi R, Naito H.
- Organizer
  The 3rd Congress, International Academy of Sportology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07182
[Presentation] 温熱刺激とロイシン摂取の組み合わせが高齢マウスの筋量および筋機能に及ぼす影響2017
- Author(s)
  柿木亮、後藤亜由美、吉原利典、都築孝允、内藤久士
- Organizer
  第72回日本体力医学会大会
- Data Source
  KAKENHI-PROJECT-16K16565
[Presentation] 男性短距離走者の骨格筋におけるACTN3タンパク質発現量と筋線維組成2013
- Author(s)
  中村智洋、柿木亮、関根紀子、小林裕幸、佐久間和彦、内藤久士
- Organizer
  第58回日本体力医学会大会
- Place of Presentation
  教育会館（東京）、日本
- Data Source
  KAKENHI-PROJECT-24700703
[Presentation] Submaximal cycling exercise stimulates mTOR signaling pathway in human skeletal muscle.2013
- Author(s)
  Kakigi R, Naito H, Yoshihara T, Ozaki H, Kobayashi H, Okada T.
- Organizer
  Experimental biology 2013
- Place of Presentation
  Boston, USA.
- Data Source
  KAKENHI-PROJECT-24700703
[Presentation] ラット骨格筋の過負荷によるmTORシグナル伝達経路の活性化に持久性運動における強度の違いが及ぼす影響2013
- Author(s)
  尾崎隼雄、柿木亮、内藤久士
- Organizer
  第58回日本体力医学会大会
- Place of Presentation
  教育会館（東京）、日本
- Data Source
  KAKENHI-PROJECT-24700703
[Presentation] 最大下自転車運動によるヒト骨格筋Akt/mTORシグナル伝達の経時変化2013
- Author(s)
  柿木亮、内藤久士、吉原利典、尾崎隼朗、都築孝允、小林裕幸、岡田隆夫
- Organizer
  第58回日本体力医学会大会
- Place of Presentation
  教育会館（東京）、日本
- Data Source
  KAKENHI-PROJECT-24700703
[Presentation] Whey protein ingestion after exercise decreases LC3-II expression in human muscle.2012
- Author(s)
  Kakigi R.
- Organizer
  15th International Biochemistry of Exercise Conference.
- Place of Presentation
  Stockholm, Sweden.
- Data Source
  KAKENHI-PROJECT-24700703
[Presentation] Effects of whey peptide ingestion after resistance exercise on mTOR signaling in human skeletal muscle.2012
- Author(s)
  Kakigi R.
- Organizer
  The American College of Sports Medicine 59th Annual Meeting.
- Place of Presentation
  Sanfrancisco, USA.
- Data Source
  KAKENHI-PROJECT-24700703
[Presentation] Eccentric muscle contraction stimulates mTOR signaling in human skeletal muscle
- Author(s)
  Kakigi R, Naito H, Yoshihara T, Ichinoseki-Sekine N, Okada T.
- Organizer
  The 92nd Annual Meeting of The Physiological Society of Japan
- Place of Presentation
  Kobe, Japan
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-24700703
[Presentation] 伸張性収縮運動によるヒト骨格筋mTORシグナルの増加は鍛練度によって異なる
- Author(s)
  柿木亮、内藤久士、吉原利典、坂本彰宏、中村智洋、小林裕幸、岡田隆夫
- Organizer
  第69回日本体力医学会大会
- Place of Presentation
  長﨑、日本
- Year and Date
  2014-09-19 – 2014-09-21
- Data Source
  KAKENHI-PROJECT-24700703

1. YOSHIHARA Toshinori (20722888)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
2. Iesaki Takafumi (10348956)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. NAITO Hisashi (70188861)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. 渡邉マキノ (00255655)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 杉原匡美 (80648163)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. 村山尚 (10230012)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. 呉林なごみ (50133335)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. Hashimoto Ryota (60433786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Goto Ayumi (20780969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. TSUZUKI Takamasa (20780068)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
11. 岡本瑞穂 (90964148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 町田修一 (40421226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 国広なごみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Kakigi Ryo 柿木 亮

KAKIGI RYO 柿木 亮

Research Projects

Research Products

Co-Researchers

家族性拡張型心筋症モデルにおける運動療法の効果

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

筋サテライト細胞の活性化を基盤としたヒト骨格筋適応メカニズムの性差の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The construction of exercise therapy in familial DCM model mice

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

骨格筋適応の性差を司るアンジオテンシン受容体制御機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ビタミンD不足はサルコペニア進行の増悪因子なのか？Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of physiological mechanism(s) of magnesium deficiency-induced hypertension

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms underlying heat stress-induced skeletal muscle adaptation in prevention of sarcopeniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of heat stress on body fat mass and muscle mass in mice with sarcopenia obesity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the mechanism of nitric oxide production by an extract of brown marine algae and its usefulness as a functional food

Principal Investigator

Project Period (FY)

Research Category

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Effect of muscle contraction mode on intracellular signaling-related muscle hypertrophyPrincipal Investigator

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[Journal Article] Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles2022

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[Journal Article] Long-term physical inactivity exacerbates hindlimb unloading-induced muscle atrophy in young rat soleus muscle2021

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[Journal Article] Maintenance of contractile force and increased fatigue resistance in slow-twitch skeletal muscle of mice fed a high-fat diet2021

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Kakigi Ryo 柿木亮

KAKIGI RYO 柿木亮