Harashima Ai 原島愛

… Alternative Names

HARASHIMA Ai 原島愛

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Researcher Number	50705522
Other IDs
Affiliation (Current)	2025: 金沢大学, 医学系, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 金沢大学, 医学系, 助教 2015 – 2021: 金沢大学, 医学系, 助教 2014: 金沢大学, 脳・肝インターフェースメディシン研究センター, 特任助教 2013: 金沢大学, 脳・肝インターフェースメディシン研究センター, 助教
Review Section/Research Field	Principal Investigator General medical chemistry / Basic Section 49010:Pathological biochemistry-related / Basic Section 52030:Psychiatry-related Except Principal Investigator Orthopaedic surgery / Basic Section 48040:Medical biochemistry-related / Basic Section 59040:Nutrition science and health science-related / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 48030:Pharmacology-related
Keywords	Principal Investigator 転写調節 / エピゲノム / 遺伝子多型 Except Principal Investigator RAGE / 糖化蛋白受容体 / 幹細胞 / 骨肉腫 / がん悪性化 / 糖化ストレス / 糖・脂質代謝 … More / glyoxalase / 統合失調症 / C. elegans / 線虫 / Glyoxalase / Glyoxlase / 愛情 / 子育て / 血液脳関門 / オキシトシン / がん幹細胞 / 骨・軟部腫瘍学 Less

糖尿病におけるバソプレシンの構造・機能変化と病態形成機序の解明Principal Investigator
- Principal Investigator
  
  原島愛
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kanazawa University
非アルコール性脂肪肝炎を克服するための多重戦略
- Principal Investigator
  
  木村久美
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kanazawa University
RAGE膜貫通ドメインと結合する分子の発見とがん細胞悪性化機構の解明
- Principal Investigator
  
  棟居聖一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kanazawa University
Mechanisms of epigenetic regulation of glod-4/GLO1 gene in C. elegans
- Principal Investigator
  
  Shin-ichi Harada
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kanazawa University
Investigation of molecular devices for oxytocin transport into the brain
- Principal Investigator
  
  Yamamoto Yasuhiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kanazawa University
Understanding of pathophysiological mechanisms and development of the treatment of schizophrenia based on novel gene polymorphisms of glyoxalase 1.Principal Investigator
- Principal Investigator
  
  Harashima Ai
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kanazawa University
A novel polymorphism-driven transcriptional regulation of human glyoxalase 1 genePrincipal Investigator
- Principal Investigator
  
  Harashima Ai
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kanazawa University
Establishment of osteosarcoma stem cell model induced by RAGE and elucidation of its molecular mechanism
- Principal Investigator
  
  Takeuchi Akihiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kanazawa University
Analysis of novel transcription regulation mechanism of glyoxalase 1Principal Investigator
- Principal Investigator
  
  Harashima Ai
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kanazawa University
Identifying challenges to discover cancer stem-like cells in osteosarcoma
- Principal Investigator
  
  TAKEUCHI Akihiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kanazawa University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Patent

[Journal Article] Assaying ADAMTS13 Activity as a Potential Prognostic Biomarker for Sinusoidal Obstruction Syndrome in Mice2023
- Author(s)
  Saeki Masakazu、Munesue Seiichi、Higashi Yuri、Harashima Ai、Takei Ryohei、Takada Satoshi、Nakanuma Shinichi、Ohta Tetsuo、Yagi Shintaro、Tajima Hidehiro、Yamamoto Yasuhiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 22 Pages: 16328-16328
- DOI
  10.3390/ijms242216328
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18310, KAKENHI-PROJECT-20K09029, KAKENHI-PROJECT-23K06376, KAKENHI-PROJECT-21H02695
[Journal Article] A nonsteroidal anti-inflammatory drug, zaltoprofen, inhibits the growth of extraskeletal chondrosarcoma cells by inducing PPARγ, p21, p27, and p532022
- Author(s)
  Higuchi T, Takeuchi A, Munesue S, Yamamoto N, Hayashi K, Harashima A, Yamamoto Y, Tsuchiya H
- Journal Title
  
  Cell Cycle
  
  Volume: 22 Issue: 8 Pages: 939-950
- DOI
  10.1080/15384101.2023.2166195
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22802, KAKENHI-PROJECT-22K09396, KAKENHI-PROJECT-23K06376, KAKENHI-PROJECT-21K09317, KAKENHI-PROJECT-21H02695
[Journal Article] Receptor for advanced glycation end-products (RAGE) plays a critical role in retrieval behavior of mother mice at early postpartum.2021
- Author(s)
  Gerasimenko M, Lopatina O, Munesue S, Harashima A, Yokoyama S, Yamamoto Y, Higashida H.
- Journal Title
  
  Physiol Behav
  
  Volume: 235 Pages: 113395-113395
- DOI
  10.1016/j.physbeh.2021.113395
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07551, KAKENHI-PROJECT-20K07323, KAKENHI-PROJECT-21H02695
[Journal Article] RAGE signaling antagonist suppresses mouse macrophage foam cell formation.2021
- Author(s)
  Leerach N, Munesue S, Harashima A, Kimura K, Oshima Y, Kawano S, Tanaka M, Niimura A, Sakulsak N, Yamamoto H, Hori O, Yamamoto Y.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 555 Pages: 74-80
- DOI
  10.1016/j.bbrc.2021.03.139
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07551, KAKENHI-PROJECT-21H02695
[Journal Article] Transport of oxytocin to the brain after peripheral administration by membrane-bound or soluble forms of receptors for advanced glycation end-products.2021
- Author(s)
  Munesue S, Liang MingKun, Harashima A, Zhong J, Furuhara K, Boitsova E, Cherepanov SM, Gerasimenko M, Yuhi T, Yamamoto Y, Higashida H.
- Journal Title
  
  J Neuroendocrinol
  
  Volume: 33 Issue: 3
- DOI
  10.1111/jne.12963
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07551, KAKENHI-PROJECT-21H02695
[Journal Article] Pyridoxamine improves diabetes-evoked delayed bone repair in mice.2021
- Author(s)
  Ugaji S, Kimura K, Yamamoto Y, Munesue S, Harashima A, Aikawa T, Yoshida Y, Hamada T, Hikichi T, Matsubara H, Tsuchiya H.
- Journal Title
  
  J Transl Sci
  
  Volume: in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07551
[Journal Article] Glycation reaction and the role of the receptor for advanced glycation end-products in immunity and social behavior2020
- Author(s)
  Leerach Nontaphat、Harashima Ai、Munesue Seiichi、Kimura Kumi、Oshima Yu、Goto Hisanori、Yamamoto Hiroshi、Higashida Haruhiro、Yamamoto Yasuhiko
- Journal Title
  
  Glycoconjugate Journal
  
  Volume: in press Issue: 3 Pages: 303-310
- DOI
  10.1007/s10719-020-09956-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-18K07551, KAKENHI-PROJECT-21H02695
[Journal Article] Aquaporin 1 elicits cell motility and coordinates vascular bed formation by downregulating thrombospondin type-1 domain-containing 7A in glioblastoma2020
- Author(s)
  Oishi M, Munesue S, Harashima A, Nakada M, Yamamoto Y, Hayashi Y
- Journal Title
  
  Cancer Med
  
  Volume: 9 Issue: 11 Pages: 3904-3917
- DOI
  10.1002/cam4.3032
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-18H02910, KAKENHI-PROJECT-18K07551, KAKENHI-PROJECT-19K18420
[Journal Article] Neuroprotective effects of endogenous secretory receptor for advanced glycation end-products in brain ischemia2020
- Author(s)
  Simizu Y, Harashima A, Munesue S, Oishi M, Hattori T, Hori O, Kitao Y, Yamamoto H, Leerach N, Nakada M, Yamamoto Y, Hayashi Y
- Journal Title
  
  Aging Dis
  
  Volume: 11 Issue: 3 Pages: 547-547
- DOI
  10.14336/ad.2019.0715
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-18K06501, KAKENHI-PROJECT-18K06500
[Journal Article] Neuroprotective effects of endogenous secretory receptor for advanced glycation end-products in brain ischemia.2019
- Author(s)
  Shimizu Y, Harashima A, Munesue S, Oishi M, Hattori T, Hori O, Kitao Y, Yamamoto H, Leerach N, Nakada M, Yamamoto Y, Hayashi Y.
- Journal Title
  
  Aging Dis
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07551
[Journal Article] Protective role of endogenous secretory RAGE against contact hypersensitivity in mouse ear skin.2019
- Author(s)
  Sagara A, Harashima A, Munesue S, Kimura K, Leerach N, Oshima Y, Kinoshita Y, Sakai N, Kaneko S, Wada T, Tsuneyama K, Yamamoto H, Yamamoto Y
- Journal Title
  
  Glycative Stress Research
  
  Volume: 6 Issue: 4 Pages: 270-277
- DOI
  10.24659/gsr.6.4_270
- NAID
  40022229100
- ISSN
  2188-3602, 2188-3610
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06889
[Journal Article] CD38, CD157, and RAGE as Molecular Determinants for Social Behavior.2019
- Author(s)
  .Higashida H, Hashii M, Tanaka Y, Matsukawa S, Higuchi Y, Gabata R, Tsubomoto M, Seishima N, Teramachi M, Kamijima T, Hattori T, Hori O, Tsuji C, Cherepanov SM, Shabalova AA, Gerasimenko M, Minami K, Yokoyama S, Munesue SI, Harashima A, Yamamoto Y, Salmina AB, Lopatina O.
- Journal Title
  
  Cells.
  
  Volume: 9(1) Issue: 1 Pages: 62-62
- DOI
  10.3390/cells9010062
- NAID
  120006859506
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06500, KAKENHI-PROJECT-18K06501, KAKENHI-PROJECT-18K06521, KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-18K07551, KAKENHI-PROJECT-18KK0435, KAKENHI-PROJECT-18KK0255
[Journal Article] Citrullinated histone H3: early biomarker of neutrophil extracellular traps in septic liver damage2019
- Author(s)
  Nomura K, Miyashita T, Yamamoto Y, Munesue S, Harashima A, Takayama H, Fushida S, Ohta T
- Journal Title
  
  J Surg Res
  
  Volume: 234 Pages: 132-138
- DOI
  10.1016/j.jss.2018.08.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-18K07551
[Journal Article] Monitoring of Heat Shock Response and Phenotypic Changes in Hepatocellular Carcinoma After Heat Treatment2019
- Author(s)
  Zaimoku R, Miyashita T, Tajima H, Takamura H, Harashima A, Munesue S, Yamamoto Y, Ninomiya I, Fushida S, Harada K
- Journal Title
  
  Anticancer Research
  
  Volume: 39 Issue: 10 Pages: 5393-5401
- DOI
  10.21873/anticanres.13733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-18K07551
[Journal Article] Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice.2019
- Author(s)
  Yamamoto Y, Liang M, Munesue S, Deguchi K, Harashima A, Furuhara K, Yuhi T, Zhong J, Akther S, Goto H, Eguchi Y, Kitao Y, Hori O, Shiraishi Y, Ozaki N, Shimizu Y, Kamide T, Yoshikawa A, Hayashi Y, Nakada M, Lopatina O, Gerasimenko M, Komleva Y, Malinovskaya N, Salmina AB, Asano M, Nishimori K, Higashida H et al.,
- Journal Title
  
  Commun Biol
  
  Volume: ２ Issue: 1 Pages: 76-76
- DOI
  10.1038/s42003-019-0325-6
- NAID
  120006605138
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09031, KAKENHI-PROJECT-18K06500, KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-18K07551, KAKENHI-PROJECT-18KK0255
[Journal Article] Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia2019
- Author(s)
  Hosokawa K, Mizumaki H, Elbadry M, Saito C, Espinoza JL, An DTT, Katagiri T, Harashima A, Kikuchi A, Kanai A, Matsui H, Inaba T, Taniwaki M, Yamamoto Y, Nakao S
- Journal Title
  
  Leukemia
  
  Volume: 33 Issue: 11 Pages: 2732-2766
- DOI
  10.1038/s41375-019-0510-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-18K07551, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K17823, KAKENHI-PROJECT-19H03686, KAKENHI-PROJECT-17K09007, KAKENHI-PROJECT-17K09822
[Journal Article] Protective role of endogenous secretory RAGE against contact hypersensitivity in mouse ear skin.2019
- Author(s)
  Sagara A, Harashima A, Munesue S, Kimura K, Leerach N, Oshima Y, Kinoshita Y, Sakai N, Kaneko S, Wada T, Tsuneyama K, Yamamoto H, Yamamoto Y.
- Journal Title
  
  Glycative Stress Res
  
  Volume: 6 Pages: 270-277
- NAID
  40022229100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07551
[Journal Article] In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system2018
- Author(s)
  El-Far Ali、Munesue Seiichi、Harashima Ai、Sato Akira、Shindo Mika、Nakajima Shingo、Inada Mana、Tanaka Mariko、Takeuchi Akihiko、Tsuchiya Hiroyuki、Yamamoto Hiroshi、Shaheen Hazem、El-Sayed Yasser、Kawano Shuhei、Tanuma Sei-Ichi、Yamamoto Yasuhiko
- Journal Title
  
  Oncology Letters
  
  Volume: 15 Pages: 4627-4634
- DOI
  10.3892/ol.2018.7902
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08327, KAKENHI-PROJECT-17K08550, KAKENHI-PROJECT-15H04315, KAKENHI-PROJECT-15K10435, KAKENHI-PROJECT-16K15658, KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-18K07551, KAKENHI-PROJECT-18K09058
[Journal Article] Anti-tumor effects of a non-steroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression.2018
- Author(s)
  Higuchi T, Takeuchi, A, Munesue S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Inatani H, Shimozaki S, Kato T, Aoki Y, Abe K, Taniguchi Y, Aiba H, Murakami H, Harashima A, Yamamoto Y, Tsuchiya H
- Journal Title
  
  Cancer Med
  
  Volume: in press
- NAID
  120006605139
- Open Access
- Data Source
  KAKENHI-PROJECT-16K19031
[Journal Article] Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression.2018
- Author(s)
  Higuchi T, Takeuchi A, Munesue S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Inatani H, Shimozaki S, Kato T, Aoki Y, Abe K, Taniguchi Y, Aiba H, Murakami H, Harashima A, Yamamoto Y, Tsuchiya H.
- Journal Title
  
  Cancer Med.
  
  Volume: 印刷中 Issue: 5 Pages: 1944-1954
- DOI
  10.1002/cam4.1438
- NAID
  120006605139
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10435, KAKENHI-PROJECT-16K15658, KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-18K07551, KAKENHI-PROJECT-18K09058
[Journal Article] In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system.2018
- Author(s)
  El-Far A, Munesue S, Harashima A, Sato A, Shindo M, Nakajima S, Inada M, Tanaka M, Takeuchi A, Tsuchiya H, Yamamoto H, Shaheen HME, El-Sayed YS, Kawano S, Tanuma S, Yamamoto Y
- Journal Title
  
  Oncology Lett
  
  Volume: 15 Pages: 4627-4634
- NAID
  120006605140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19031
[Journal Article] Perception of pathogenic bacteria by pattern recognition receptor RAGE in the frontline.2017
- Author(s)
  Harashima A, Yamamoto Y
- Journal Title
  
  IMARS Highlights
  
  Volume: 12 Pages: 5-7
- Data Source
  KAKENHI-PROJECT-16K19031
[Journal Article] Low-dose paclitaxel suppresses the induction of M2 macrophages in gastric cancer.2017
- Author(s)
  Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H and Ohta T.
- Journal Title
  
  Oncology Rep
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19031
[Journal Article] Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice.2017
- Author(s)
  Higashida H, Furuhara K, Yamauchi AM, Deguchi K, Harashima A, Munesue S, Lopatina O, Gerasimenko M, Salmina AB, Zhang JS, Kodama H, Kuroda H, Tsuji C, Suto S, Yamamoto H, Yamamoto Y
- Journal Title
  
  Sci Rep
  
  Volume: 11 Pages: 1-15
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19031
[Journal Article] Contribution of methylglyoxal to delayed healing of bone injury in diabetes.2017
- Author(s)
  Aikawa T, Matsubara H, Ugaji S, Shirakawa J, Nagai R, Munesue S, Harashima A, Yamamoto Y and Tsuchiya H.
- Journal Title
  
  Mol Med Rep
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19031
[Journal Article] Preventive effect of salicylate and pyridoxamine on diabetic nephropathy2016
- Author(s)
  Abouzed TK, Munesue S, Harashima A, Masuo Y, Kato Y, Kahilo KK, Yamamoto H, Yamamoto Y
- Journal Title
  
  J. Diabetes Res
  
  Volume: 1786789 Pages: 1-10
- DOI
  10.1155/2016/1786789
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450152, KAKENHI-PROJECT-15K15000, KAKENHI-PROJECT-16K19031
[Journal Article] Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination.2015
- Author(s)
  Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T.
- Journal Title
  
  Gastric Cancer
  
  Volume: 18 Issue: 4 Pages: 1-14
- DOI
  10.1007/s10120-015-0579-8
- NAID
  40020959187
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450152, KAKENHI-PROJECT-25462015, KAKENHI-PROJECT-26860187, KAKENHI-PROJECT-16K19031
[Journal Article] cAMP ameliorates inflammation in macrophages by modulation of receptor for advanced glycation end-products.2014
- Author(s)
  Motoyoshi S, Yamamoto Y, Munesue S, Igawa H, Harashima A, Saito H, Han H, Watanabe T, Sato H, Yamamoto H.
- Journal Title
  
  Biochem J
  
  Volume: 463(1) Issue: 1 Pages: 75-82
- DOI
  10.1042/bj20140084
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590375, KAKENHI-PROJECT-25461335, KAKENHI-PROJECT-26450152, KAKENHI-PROJECT-26860187
[Journal Article] Low molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression of malignant phenotype in human fibrosarcoma cells.2013
- Author(s)
  Takeuchi A, Yamamoto Y, Munesue S, Harashima A, Watanabe T, Yonekura H, Yamamoto H, Tsuchiya H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 104(6) Issue: 6 Pages: 740-749
- DOI
  10.1111/cas.12133
- NAID
  120005830605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590349, KAKENHI-PROJECT-23791629, KAKENHI-PROJECT-24590375, KAKENHI-PROJECT-25461335
[Patent] 乳児の社会脳発達促進用栄養組成物2017
- Inventor(s)
  山本靖彦、原島　愛、他2名
- Industrial Property Rights Holder
  山本靖彦、原島　愛、他2名
- Industrial Property Rights Type
  特許
- Filing Date
  2017-03-14
- Data Source
  KAKENHI-PROJECT-16K19031
[Patent] GLO1の発現が関与する疾患の存在の検出方法、該検出方法にに使用するマーカー、GLO1酵素活性向上剤およびGLO1酵素活性低減剤2016
- Inventor(s)
  山本靖彦、原島　愛、他8名
- Industrial Property Rights Holder
  山本靖彦、原島　愛、他8名
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-096027
- Filing Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-16K19031
[Patent] オキシトシントランスポーター2014
- Inventor(s)
  東田陽博、山本靖彦、山本博、棟居聖一、原島愛、堀修、出口喜三郎
- Industrial Property Rights Holder
  東田陽博、山本靖彦、山本博、棟居聖一、原島愛、堀修、出口喜三郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-255721
- Filing Date
  2014-12-18
- Data Source
  KAKENHI-PROJECT-26860187
[Patent] オキシトシン検出のためのサンプルの前処理方法2014
- Inventor(s)
  東田陽博、山本靖彦、棟居聖一、原島愛、出口喜三郎
- Industrial Property Rights Holder
  東田陽博、山本靖彦、棟居聖一、原島愛、出口喜三郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-255756
- Filing Date
  2014-12-18
- Data Source
  KAKENHI-PROJECT-26860187
[Presentation] RAGEを介したヒト骨肉腫細胞悪性化の分子機構の解明2023
- Author(s)
  棟居聖一、武内章彦、原島　愛、木村久美、大島由、Wah Wah Aung、田中麻莉子、Yupa Srithongchai、桜井彩那、山本靖彦
- Organizer
  第33回　日本メイラード学会
- Data Source
  KAKENHI-PROJECT-23K06376
[Presentation] 可溶型RAGEは脳血管内皮細胞上の膜型RAGEによる血中オキシトシンの脳内輸送を阻害しない2020
- Author(s)
  棟居聖一、原島愛、木村久美、Nontaphat Leerach、大島由、新村朱子、東田陽博、山本靖彦
- Organizer
  第30回日本メイラード学会（オンライン）
- Data Source
  KAKENHI-PROJECT-18K07551
[Presentation] Beneficial effects of zaltprofen on anti-obesity/diabetes via activation of PPARγ2019
- Author(s)
  Kimura K, Furukawa A, Watanebe K, Munesue S, Harashima A, Leerach N, Oshima Y, Tanaka M, Kawano S, Kinoshita Y, Nagashimada M, Higuchi T, Takeuchi A, Yamamoto Y
- Organizer
  International Symposium on Chronic Disease and Glycation Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06889
[Presentation] AQP1-elicited invasion and angiogenesis is mediated by thrombospondin type 1 domain containing 7A (THSD7A) in glioblastoma multiforme2019
- Author(s)
  Oishi M, Yamamoto Y, Munesue S, Harashima S, Nakada M, Hayashi Y
- Organizer
  International Symposium on Chronic Disease and Glycation Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06889
[Presentation] 細胞内メチルグリオキサールの可視化解析2019
- Author(s)
  引地俊文, 木村久美, 棟居聖一, 原島愛, Nontaphat Leerach, 大島由, 木下結衣, 松原秀憲, 土屋弘行, 山本靖彦
- Organizer
  第29回日本メイラード学会年会
- Data Source
  KAKENHI-PROJECT-18K07551
[Presentation] Effects of salicylate and pyridoxamine on diabetic nephropathy2019
- Author(s)
  Munesue S, Abouzed TK, Harashima A, Yamamoto H, Yamamoto Y
- Organizer
  International Symposium on Chronic Disease and Glycation Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06889
[Presentation] In vitro effects of a novel RAGE inhibitor on tumor malignancy in human fibrosarcoma HT1080 cells2019
- Author(s)
  Oshima Y, Munesue S, El-Far AM, Harashima A, Takeuchi A, Tanaka M, Kawano S, Sato S, Shindo M, Nakajima S, Inada A, Tanuma S, Yamamoto H, Yamamoto Y
- Organizer
  International Symposium on Chronic Disease and Glycation Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06889
[Presentation] 原子間力顕微鏡を用いたグリケーションの可視化への挑戦2019
- Author(s)
  木下結衣、棟居聖一、木村久美、原島愛、Nontaphat Leerach、大島由、古寺哲幸、山本靖彦
- Organizer
  第29回日本メイラード学会年会
- Data Source
  KAKENHI-PROJECT-18K07551
[Presentation] Drug library screening to identify new compounds for inducing ectodomain shedding of RAGE and formation of soluble RAGE2019
- Author(s)
  Kawano S, Miyazawa H, Munesue S, Harashima A, Tanaka M, Thoa DTM, Leerach N, Ooshima Y, Kinoshita Y, Yamamoto H, Yamamoto Y
- Organizer
  International Symposium on Chronic Disease and Glycation Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06889
[Presentation] Pathological and physiological roles of a pattern-recognition receptor RAGE2019
- Author(s)
  Yamamoto Y, Munesue S, Harashima A, Kimura K, Leerach N, Oshima Y, Kinoshita Y
- Organizer
  9th International DAMPs and Alarmins Symposium (9th iDEAs)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06889
[Presentation] RAGE細胞内シグナル伝達阻害剤によるマクロファージ浸潤・泡沫化抑制効果2018
- Author(s)
  Nontaphat LEERACH、棟居聖一、原島　愛、木村久美、大島　由、河野修平、田中麻莉子、木下結衣、山本靖彦
- Organizer
  第28回日本メイラード学会
- Data Source
  KAKENHI-PROJECT-18K07551
[Presentation] Drug library screening to identify new compounds for inducing ectodomain shedding of RAGE and formation of soluble RAGE2018
- Author(s)
  Shuhei Kawano, Hanae Miyazawa, Seiichi Munesue, Ai Harashima, Mariko Tanaka, Duong Thi Minh Thoa, Nontaphat Leerach, Yu Ooshima, Yui Kinoshita, Hiroshi Yamamoto, Yasuhiko Yamamoto
- Organizer
  13th International Symposium on the Maillard Reaction
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07551
[Presentation] 新規RAGE阻害薬による線維肉腫細胞の悪性化抑制効果の検討2018
- Author(s)
  山本靖彦、棟居聖一、原島　愛、武内章彦、田中麻莉子、河野修平、佐藤　聡、新藤実香、中島槙吾、稲田　愛、田沼靖一
- Organizer
  第18回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-18K07551
[Presentation] In vitro anticancer effects of a novel RAGE inhibitor on suppression of tumor malignant phenotypes in human fibrosarcoma cells2018
- Author(s)
  Seiichi Munesue, Ai Harashima, Akihiko Takeuchi, Mariko Tanaka, Shuhei Kawano, Nantaphat Leerach, Yu Ooshima, Yui Kinoshita, Akira Sato, Mika Shindo, Shingo Nakajima, Mana Inada, Sei-ichi Tanuma, Yasuhiko Yamamoto
- Organizer
  13th International Symposium on the Maillard Reaction
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07551
[Presentation] 新規RAGE阻害薬による線維肉腫細胞腫瘍悪性の抑制効果の検討2017
- Author(s)
  棟居聖一、ALI HAFEZ ALI MOHAMMED EL-FAR、原島　愛、武内章彦、河野修平、田中麻莉子、佐藤　聡、中島槙吾、田沼靖一、山本靖彦
- Organizer
  第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K19031
[Presentation] RAGE切断を誘導する薬剤スクリーニングと疾患の制御2017
- Author(s)
  河野　修平、宮澤　英恵、棟居　聖一、原島　愛、Duong Thi Minh Thoa、 Nontaphat Leerach、山本　靖彦
- Organizer
  第27回メイラード学会
- Data Source
  KAKENHI-PROJECT-16K19031
[Presentation] Novel polymorphisms in promoter region of human glyoxalase 1 regulate its transcription and are associated with aging-related diseases2017
- Author(s)
  Ai Harashima, Seiichi Munesue, Junnosuke Miura, Yasuko Uchigata, Hiroshi Yamamoto, Yasuhiko Yamamoto
- Organizer
  Keystone Symposia Conference Aging and Mechanisms of Aging-Related Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19031
[Presentation] 抗炎症薬サリチル酸と抗糖化薬ピリドキサミンによるマウス糖尿病腎症予防効果の比較検討2017
- Author(s)
  棟居聖一、Tarek Kamal Abouzed、原島愛、山本博、山本靖彦
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K19031
[Presentation] 線維肉腫細胞の悪性化形質に及ぼす新規RAGE阻害薬の効果の検討2017
- Author(s)
  棟居聖一、原島　愛、武内章彦、田中麻莉子、河野修平、佐藤　聡、新藤実香、中島槙吾、稲田　愛、田沼　靖一、山本靖彦
- Organizer
  第27回メイラード学会
- Data Source
  KAKENHI-PROJECT-16K19031
[Presentation] 抗炎症薬サリチル酸と抗糖化薬ピリドキサミンによるマウス糖尿病腎症予防効果の検討2017
- Author(s)
  原島　愛、棟居聖一、Tarek Kamal Abouzed、河野修平、田中麻莉子、増尾友佑、加藤将夫、山本　博、山本靖彦
- Organizer
  第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K19031
[Presentation] RAGE阻害薬の腫瘍悪性形成に及ぼす効果の検討2016
- Author(s)
  棟居聖一、原島　愛、武内章彦、佐藤　聡、中島槙吾、田沼靖一、山本靖彦
- Organizer
  第26回日本メイラード学会年会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2016-11-11
- Data Source
  KAKENHI-PROJECT-16K19031
[Presentation] 糖化ストレス除去酵素の転写調節機構2016
- Author(s)
  原島　愛
- Organizer
  脳・肝インターフェースメディシン研究センター生体統御部門外部評価シンポジウム
- Place of Presentation
  金沢大学十全記念スタジオ
- Year and Date
  2016-03-08
- Invited
- Data Source
  KAKENHI-PROJECT-26860187
[Presentation] ヒトGlyoxalase1 (GLO1)の新規ホモポリマー遺伝子多型による転写調節機構2016
- Author(s)
  原島　愛、棟居聖一、山本靖彦
- Organizer
  第26回日本メイラード学会年会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2016-11-11
- Data Source
  KAKENHI-PROJECT-16K19031
[Presentation] Glyoxalase1 promoter polymorphism regulates gene transcription 抗糖化酵素Glyoxalase 1のプロモーター遺伝子多型による転写調節機構2016
- Author(s)
  原島　愛、棟居聖一、山本博、山本靖彦
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター・東北大学川内北キャンパス
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K19031
[Presentation] 内在性分泌型RAGEは脳虚血から神経細胞を保護する2015
- Author(s)
  清水　有、山本靖彦、原島　愛、棟居聖一、大石正博、林　康彦、中田光俊、北尾康子、堀　修、山本　博
- Organizer
  第30回日本糖尿病合併症学会
- Place of Presentation
  愛知県産業労働センター　ウインク愛知
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-26860187
[Presentation] 低分子ヘパリンは線維肉腫細胞における後期糖化産物受容体(RAGE)を介する悪性度を抑制する2013
- Author(s)
  武内章彦,山本靖彦,棟居聖一,原島愛,山本憲男,土屋弘行
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23791629
[Presentation] 内在性分泌型RAGEは血液脳関門を越えて神経細胞を保護する
- Author(s)
  清水　有、山本靖彦、原島　愛、棟居聖一、林　康彦、北尾康子、堀　修、山本　博
- Organizer
  第24回日本メイラード学会年会
- Place of Presentation
  熊本市国際交流会館
- Year and Date
  2014-11-07 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-26860187
[Presentation] 食品由来AGEによるAGE-RAGEシグナルの阻害効果
- Author(s)
  棟居聖一、山本靖彦、原島　愛、漆原涼太、齋藤英仁、本吉　創、渡辺琢夫、山本　博
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪国際会議場、リーガロイヤルホテル、ホテルNCB、堂島リバーフォーラム
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26860187
[Presentation] 内在性分泌型RAGEは血管脳関門を越えてデコイ受容体としての神経細胞保護作用を発揮する
- Author(s)
  清水　有、山本靖彦、原島　愛、棟居聖一、大石正博、林　康彦、北尾康子、堀　修、山本　博
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26860187

1. MUNESUE Seiichi (10399040)

# of Collaborated Projects: 6 results

# of Collaborated Products: 29 results
2. YAMAMOTO Yasuhiko (20313637)

# of Collaborated Projects: 5 results

# of Collaborated Products: 18 results
3. 木村久美 (60409472)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. TAKEUCHI Akihiko (70512218)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. Shin-ichi Harada (90272955)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 後藤久典 (60882488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SATO Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 田沼靖一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 八木真太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 樋口貴史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 山本博

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. 堀修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 尾崎紀之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 米倉秀人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Harashima Ai 原島 愛

HARASHIMA Ai 原島 愛

Research Projects

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Co-Researchers

糖尿病におけるバソプレシンの構造・機能変化と病態形成機序の解明Principal Investigator

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非アルコール性脂肪肝炎を克服するための多重戦略

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RAGE膜貫通ドメインと結合する分子の発見とがん細胞悪性化機構の解明

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Mechanisms of epigenetic regulation of glod-4/GLO1 gene in C. elegans

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Investigation of molecular devices for oxytocin transport into the brain

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Understanding of pathophysiological mechanisms and development of the treatment of schizophrenia based on novel gene polymorphisms of glyoxalase 1.Principal Investigator

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A novel polymorphism-driven transcriptional regulation of human glyoxalase 1 genePrincipal Investigator

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Establishment of osteosarcoma stem cell model induced by RAGE and elucidation of its molecular mechanism

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Analysis of novel transcription regulation mechanism of glyoxalase 1Principal Investigator

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Identifying challenges to discover cancer stem-like cells in osteosarcoma

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[Journal Article] Assaying ADAMTS13 Activity as a Potential Prognostic Biomarker for Sinusoidal Obstruction Syndrome in Mice2023

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[Journal Article] A nonsteroidal anti-inflammatory drug, zaltoprofen, inhibits the growth of extraskeletal chondrosarcoma cells by inducing PPARγ, p21, p27, and p532022

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[Journal Article] Receptor for advanced glycation end-products (RAGE) plays a critical role in retrieval behavior of mother mice at early postpartum.2021

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Harashima Ai 原島愛

HARASHIMA Ai 原島愛