HARADA Shinichi 原田真市

Researcher Number	90272955
Other IDs	https://orcid.org/0000-0001-5139-532X
External Links
Affiliation (based on the past Project Information) *help	2017 – 2022: 金沢大学, 医学系, 准教授 2010 – 2016: 金沢大学, 医学系, 助教 2012: 金沢大学, 医学(系)研究科, 助教 2008: 金沢大学, 医学系, 助教 2007: 金沢大学, 医学系研究科, 助教 … More 2005 – 2006: 金沢大学, 医学系研究科, 助手 2001 – 2003: 金沢大学, 医学系研究科, 助手 1996 – 2000: 金沢大学, 医学部, 助手 1997: 金沢大学, 工学部, 助手 Less
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Basic Section 51030:Pathophysiologic neuroscience-related / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Structural biochemistry Except Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related / 電磁場環境 / General medical chemistry / Measurement engineering / Neuroscience in general / 環境影響評価(含放射線生物学)
Keywords	Principal Investigator C. elegans / C.elegans / RT-PCR / Exo70 / glyoxalase / 統合失調症 / 線虫 / Glyoxalase / Glyoxlase / gene expression … More / Calcium / microarray / Calmodulin / マイクロアレイ / 低周波交流磁界 / カルシウム / カルモジュリン / 遺伝子発現 / 交流磁界 / 寿命 / LED / LED light / Sec15 / Sec10 / Sec5 / Exocyst / Caenorhabditis elegans / sec5 / sec15 / sec10 / site-directed mutagenesis / single-strand / GFP / unc-64 / unc-18 … More Except Principal Investigator 胃癌 / 胃癌腹膜播種 / 腹膜播種 / 線維化 / candesartan / aptamer / liposome / ribozyme / nucleoside / antisense display / antisense / 癌微小環境 / パクリタキセル / 腹膜中皮細胞 / TGFβ / 腹膜転移 / TGF-β / トラニラスト / tranilast / ミスマッチ修復 / 遺伝子 / 免疫微小環境 / マウス腹膜播種モデル / 脂質代謝 / 脂肪β酸化 / FAO / CD36 / 低酸素 / IL-17産生細胞 / MKN45 / 線維化腫瘍 / 上皮間葉転換 / STAT3シグナル / 肥満細胞 / IL-17A / Angiotensin II type 1 receptor / peritoneal fibrosis / peritoneal metastasis (recurrence) / serum type IV collagen / 腹膜繊維化 / アンギオテンシンI型受容体 / 腹膜線維化 / 腹膜転移(腹膜再発) / 血清IV型コラーゲン / stress response / heat shock / RNA synthesis / mismatch repair / DNA synthesis / low-frequency high magnetic fields / 高磁場 / 生体ストレス / 熱ショック / RNA合成 / DNA合成 / 低周波変動高磁場 / 修飾オリゴヌクレオチド / リポソーム / 薬剤耐性リポソーム / 血管新生 / がん / アンチセンス / α１酸性糖蛋白 (AGP) / TLR4 / α1-酸性糖蛋白 (AGP) / 癌性腹水 / 腫瘍関連マクロファージ / エリスロマイシン / α1酸性糖蛋白 / 腫瘍浸潤マクロファージ / paclitaxel / 形質転換 / fibrocyte / 形質転換 (EMT) / 微小環境 / EMT / 非破壞検査 / 超磁歪 / バイオ計測 / 駆動装置 / 針形状プローブ / 巨大磁気抵抗センサ / うず電流探傷 / 磁気微粒子検出 / マイクロ駆動 / 非破壊検査 / 免疫学的検査法 / 低侵襲 / 磁気抵抗効果素子 / 針状プローブ / 磁気計測 / マイクロセンサ / Tranilast / TGFb / アンギオテンシンII / 線維化腹膜播種 / AVD介在ニューロン / ALM感覚ニューロン / 神経回路網 / 学習 / 記憶 / C.elegans / ベクター / ニューロン / 相乗効果 / 熱ショックタンパク質 / ELF磁界 / 生体磁気 / ヒートショックタンパク / 生体影響 / 回転磁界 / 低周波交流 / 磁界 / cDNA cloning / Functional gene screening / Vascular endothelial cells / Antisense oligonucleotides / Antisense display / Angiogeneis Less

免疫正常マウスを用いた線維性胃癌腹膜播種モデルにおける免疫抑制性微小環境の改変
- Principal Investigator
  
  伏田幸夫
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanazawa University
Mechanisms of epigenetic regulation of glod-4/GLO1 gene in C. elegansPrincipal Investigator
- Principal Investigator
  
  Shin-ichi Harada
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kanazawa University
胃癌腹膜播種における脂質代謝変容の解明と標的治療への応用
- Principal Investigator
  
  木下淳
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanazawa University
Functional analysis of IL-17 producing cells in peritoneal metastasis of gastric cancer and examination of its tumorigenecity
- Principal Investigator
  
  Fushida Sachio
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University
Molecular basis of lifespan and aging by exposing LED light in C. elegansPrincipal Investigator
- Principal Investigator
  
  Shin-ichi Harada
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kanazawa University
The function of intraperitoneal macrophage and its tumorigenesis in gastic cancer with peritoneal metastasis
- Principal Investigator
  
  Fushida Sachio
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University
Development of low-invasive/non-destructive measurements by using needle-type magnetic resistance probe with micro driving mechanism
- Principal Investigator
  
  YAMADA Sotoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Measurement engineering
- Research Institution
  Kanazawa University
Human Peritoneal Mesothelial Cell play important roles in the development of peritoneal metastasis by its EMT change
- Principal Investigator
  
  FUSHIDA Sachio
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University
Development of molecular targeted therapy via TGFb and angiotensin system for peritoneal dissemination of gastric cancer
- Principal Investigator
  
  FUSHIDA Sachio
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University
Study of extremely low frequency magnetic fields-responding mechanism in neuronPrincipal Investigator
- Principal Investigator
  
  HARADA Shinichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kanazawa University
The development of early diagnostic marker for peritoneal metastasis, and the management of tumor fibrosis through angiotensin II type I (AT1) receptor in gastric cancer.
- Principal Investigator
  
  FUSHIDA Sachio
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kanazawa University
Exocyst複合体を介した新たなシナプス伝達制御機構の解明Principal Investigator
- Principal Investigator
  
  原田真市
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kanazawa University
sec遺伝子による新たなシナプス伝達制御機構の解明Principal Investigator
- Principal Investigator
  
  原田真市
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kanazawa University
生体内特定活動ニューロンをモニターするベクター系の開発
- Principal Investigator
  
  HOSONO Ryuji
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neuroscience in general
- Research Institution
  Kanazawa University
シナプス終末で働く遺伝子群の共役的発言制御機構の解明Principal Investigator
- Principal Investigator
  
  原田真市
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kanazawa University
Influences of extremely low-frequency alternate-current high magnetic fields on gene replication, repair and expression
- Principal Investigator
  
  YAMAMOTO Hiroshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  電磁場環境
- Research Institution
  Kanazawa University
Antisense Display-新しい機能性遺伝子スクリーニング法開発の試み
- Principal Investigator
  
  YAMAMOTO Hiroshi
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kanazawa University
低周波交番・回転高磁界における遺伝子および生化学反応への影響評価の研究
- Principal Investigator
  
  YAMADA Sotoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Kanazawa University
Cooperative Research toward Antisense Diagnosis and Therapy
- Principal Investigator
  
  YAMAMOTO Hiroshi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General medical chemistry
- Research Institution
  Kanazawa University

All 2017 2016 2015 2014 2013 2012 2011

All Journal Article Presentation

[Journal Article] Establishing a xenograft mouse model of peritoneal dissemination of gastric cancer with organ invasion and fibrosis2017
- Author(s)
  Okazaki M, Fushida S, Harada S, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Ninomiya I, Ohta T
- Journal Title
  
  BMC Cancer
  
  Volume: 17(1) Issue: 1 Pages: 23-23
- DOI
  10.1186/s12885-016-2991-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430068, KAKENHI-PROJECT-16K10494
[Journal Article] Low-dose paclitaxel suppresses the induction of M2 macrophages in gastric cancer2017
- Author(s)
  Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T
- Journal Title
  
  Oncology Reports
  
  Volume: - Issue: 6 Pages: 3341-3350
- DOI
  10.3892/or.2017.5586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430068
[Journal Article] Extravasated platelet aggregation in the livers of rats with drug-induced hepatic sinusoidal obstruction syndrome2017
- Author(s)
  Hirata M, Tajima H, Miyashita T, Miyata T, Nakanuma S, Makino I, Hayashi H, Oyama K, Takamura H, Ninomiya I, Fushida S, Nakata H, Iseki S, Harada S, Wakayama T, Ohta T
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: 15(5) Issue: 5 Pages: 3147-3152
- DOI
  10.3892/mmr.2017.6407
- NAID
  120006306225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430068, KAKENHI-PROJECT-15K10158
[Journal Article] Metformin inhibits the radiation-induced invasive phenotype of esophageal squamous cell carcinoma2016
- Author(s)
  Nakayama A, Ninomiya I, Harada S, Tsukada T, Okamoto K, Nakanuma S, Sakai S, Makino I, Kinoshita J, Hayashi H, Oyama K, Miyashita T, Tajima H, Takamura H, Fushida S, Ohta T
- Journal Title
  
  Int J Oncol.
  
  Volume: 49(5) Issue: 5 Pages: 1890-1898
- DOI
  10.3892/ijo.2016.3676
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430068
[Journal Article] Valproic acid inhibits irradiation-induced epithelial-mesenchymal transition and stem cell-like characteristics in esophageal squamous cell carcinoma2016
- Author(s)
  Kanamoto A, Ninomiya I, Harada S, Tsukada T, Okamoto K, Nakanuma S, Sakai S, Makino I, Kinoshita J, Hayashi H, Oyama K, Miyashita T, Tajima H, Takamura H, Fushida S, Ohta T
- Journal Title
  
  Int J Oncol.
  
  Volume: 49(5) Issue: 5 Pages: 1859-1869
- DOI
  10.3892/ijo.2016.3712
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430068
[Journal Article] Valproic acid inhibits proliferation of HER2-expressing breast cancer cells by inducing cell cycle arrest and apoptosis through Hsp70 acetylation.2015
- Author(s)
  Mawatari T, Ninomiya I, Inokuchi M, Harada S, Hayashi H, Oyama K, Makino I, Nakagawara H, Miyashita T, Tajima H, Takamura H, Fushida S, Ohta T
- Journal Title
  
  Int J Oncol.
  
  Volume: 47(6) Issue: 6 Pages: 2073-2081
- DOI
  10.3892/ijo.2015.3213
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430068
[Journal Article] Protein-bound polysaccharide K suppresses tumor fibrosis in gastric cancer by inhibiting the TGF-β signaling pathway.2015
- Author(s)
  Shinbo T, Fushida S, Tsukada T, Harada S, Kinoshita J, Oyama K, Okamoto K, Ninomiya I, Takamura H, Kitagawa H, Fujimura T, Yashiro M, Hirakawa K, Ohta T.
- Journal Title
  
  Oncol Rep.
  
  Volume: 33(2) Issue: 2 Pages: 553-558
- DOI
  10.3892/or.2014.3636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430068
[Journal Article] Inhibitory effects of valproic acid in DNA double-strand break repair after irradiation in esophageal squamous carcinoma cells.2015
- Author(s)
  Makita N, Ninomiya I, Tsukada T, Okamoto K, Harada S, Nakanuma S, Sakai S, Makino I, Kinoshita J, Hayashi H, Oyama K, Nakagawara H, Miyashita T, Tajima H, Takamura H, Fushida S, Ohta T
- Journal Title
  
  Oncol Rep.
  
  Volume: 34(3) Issue: 3 Pages: 1185-1192
- DOI
  10.3892/or.2015.4089
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430068, KAKENHI-PROJECT-25461909, KAKENHI-PROJECT-25462107
[Journal Article] Chemoprevention of esophageal adenocarcinoma in a rat model by ursodeoxycholic acid.2015
- Author(s)
  Ojima E, Fujimura T, Oyama K, Tsukada T, Kinoshita J, Miyashita T, Tajima H, Fushida S, Harada S, Mukaisho K, Hattori T, Ohta T
- Journal Title
  
  Clin Exp Med.
  
  Volume: 15(3) Issue: 3 Pages: 343-350
- DOI
  10.1007/s10238-014-0301-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430068
[Journal Article] Bone marrow derived "fibrocytes" contribute to tumor proliferation and fibrosis in gastric cancer.2015
- Author(s)
  erai S, Fushida S, Tsukada T, Kinoshita J, Oyama K, Okamoto K, Makino I, Tajima H, Ninomiya I, Fujimura T, Harada S, Ohta T
- Journal Title
  
  Gastric Cancer
  
  Volume: 18(2) Issue: 2 Pages: 306-313
- DOI
  10.1007/s10120-014-0380-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430068
[Journal Article] Concentration-dependent radiosensitizing effect of docetaxel in esophageal squamous cell carcinoma cells.2015
- Author(s)
  Miyanaga S, Ninomiya I, Tsukada T, Okamoto K, Harada S, Nakanuma S, Sakai S, Makino I, Kinoshita J, Hayashi H, Nakamura K, Oyama K, Nakagawara H, Miyashita T, Tajima H, Takamura H, Fushida S, Ohta T
- Journal Title
  
  Int J Oncol.
  
  Volume: 48(2) Issue: 2 Pages: 517-524
- DOI
  10.3892/ijo.2015.3291
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430068, KAKENHI-PROJECT-25462107
[Journal Article] The angiotensin II type 1 receptor blocker candesartan suppresses proliferation and fibrosis in gastric cancer.2014
- Author(s)
  Okazaki M, Fushida S, Harada S, Tsukada T, Kinoshita J, Oyama K, Tajima H, Ninomiya I, Fujimura T, Ohta T.
- Journal Title
  
  Cancer Lett.
  
  Volume: 355(1) Issue: 1 Pages: 46-53
- DOI
  10.1016/j.canlet.2014.09.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430068
[Journal Article] Low-dose Paclitaxel Modulates Tumor Fibrosis in Gastric Cancer2013
- Author(s)
  Tuskada T., Fushida S., Harada S., et al
- Journal Title
  
  International Journal of Oncology
  
  Volume: 42, 4 Pages: 1167-1174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22360163
[Journal Article] Gene amplification of ESR1 in breast cancer-fact or fiction? A fluorescence in situhybridization and multiplex ligation-dependent probe amplification study2011
- Author(s)
  Ooi A, Inokuchi M, Harada S, Inazawa J, Tajiri R, Kitamura S, Ikeda H, Kawashima H, Dobashi Y
- Journal Title
  
  J Pathol
  
  Volume: No.227, Vol.1 Pages: 8-16
- NAID
  120003959480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22360163
[Presentation] Optimizing a liquid culture system for monitoring lifespan by diet manipulations in Caenorhabditis elegans2012
- Author(s)
  Thu Thu Win M., Yamamoto Y., Harada S.
- Organizer
  日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22360163
[Presentation] Optimizing a liquid culture system for monitoring lifespan by dietmanipulations in Caenorhabditis elegans2012
- Author(s)
  Thu Thu Win M., Yamamoto Y., Harada S., et al
- Organizer
  日本生化学会大会
- Place of Presentation
  福岡国際会議場(福岡県)
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-22360163

1. FUSHIDA Sachio (10301194)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. YAMAMOTO Hiroshi (00115198)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. YONEKURA Hideto (80240373)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. YAMADA Sotoshi (80019786)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. HOSONO Ryuji (40019617)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 木下淳 (90584855)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. UENO Toshiyuki (30338256)

# of Collaborated Projects: 1 results

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8. KAKIKAWA Makiko (10359713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. WAKIWAKA Hiroyuki (50240461)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TASHIRO Kunihisa (50325487)

# of Collaborated Projects: 1 results

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11. 岩原正吉 (80020212)

# of Collaborated Projects: 1 results

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12. 横山邦彦 (60230661)

# of Collaborated Projects: 1 results

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13. 米村豊 (20167042)

# of Collaborated Projects: 1 results

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14. 中島恵美 (90115254)

# of Collaborated Projects: 1 results

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15. 市村藤雄 (40143911)

# of Collaborated Projects: 1 results

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16. 原島愛 (50705522)

# of Collaborated Projects: 1 results

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17. 山本靖彦 (20313637)

# of Collaborated Projects: 1 results

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18. RAMANATHAN Murali

# of Collaborated Projects: 1 results

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19. Gunjigake Katsuya

# of Collaborated Projects: 1 results

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20. グラスビージェーン A

# of Collaborated Projects: 1 results

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21. ミカエルブラックバーン

# of Collaborated Projects: 1 results

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22. ストロービンガーロバー

# of Collaborated Projects: 1 results

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23. ファンホ・ロン

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. BLACKBURN G.Michael

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. FUNG Ho-Leung

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. STRAUBINGER Robert M.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. GRASBY J.A.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. ブラックバーンジョージ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. ストロービンガーロバ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. ロンファンホ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. BLACKBURN Je

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. GRASBY Jane

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. RAMANATHAN M

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. STRAUBINGER ロバートエム

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. FUNG HoーLeun

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HARADA Shinichi 原田 真市

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Mechanisms of epigenetic regulation of glod-4/GLO1 gene in C. elegansPrincipal Investigator

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Molecular basis of lifespan and aging by exposing LED light in C. elegansPrincipal Investigator

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Study of extremely low frequency magnetic fields-responding mechanism in neuronPrincipal Investigator

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Exocyst複合体を介した新たなシナプス伝達制御機構の解明Principal Investigator

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sec遺伝子による新たなシナプス伝達制御機構の解明Principal Investigator

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Research Institution

シナプス終末で働く遺伝子群の共役的発言制御機構の解明Principal Investigator

HARADA Shinichi 原田真市