KAJINO TAISUKE 梶野泰祐

… Alternative Names

Kajino Taisuke 梶野泰祐

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Researcher Number	50723673
Other IDs
Affiliation (Current)	2025: 愛知県がんセンター(研究所), がん標的治療TR分野, 主任研究員 2025: 愛知県がんセンター(研究所), 分子診断TR分野, 主任研究員
Affiliation (based on the past Project Information) *help	2025: 愛知県がんセンター(研究所), がん標的治療TR分野, 主任研究員 2018 – 2022: 愛知県がんセンター(研究所), 分子診断TR分野, 主任研究員 2016 – 2018: 名古屋大学, 医学系研究科, 助教 2015: 名古屋大学, 医学系研究科, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Pathological medical chemistry Except Principal Investigator Tumor biology / Basic Section 50010:Tumor biology-related / Complex systems
Keywords	Principal Investigator lncRNA / p53 / 肺がん / miRNA / miR-20a / DNA損傷応答 / TP53 / ノンコーディングRNA / 発現制御 / 核酸 / MYC … More Except Principal Investigator … More システム生物学 / 癌 / 遺伝子発現制御 / HIF-1 / TTF-1/NKX2-1 / ROR1 / シグナル伝達 / ノックアウトマウス / がん遺伝子 / がん / DSB修復 / DNA損傷 / POLD4 / DNA修復 / ゲノム不安定化 / EGFR / 肺がん / ノンコーディングRNA Less

がん特異的にp53を制御するlncRNAの分子機構の解明とがんの生存戦略の理解Principal Investigator
- Principal Investigator
  
  梶野泰祐
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Aichi Cancer Center Research Institute
Identification of molecular mechanisms how TILR regulates apoptosis in lung cancerPrincipal Investigator
- Principal Investigator
  
  Kajino Taisuke
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Aichi Cancer Center Research Institute
Analysis of gene module for genomic instability in lung cancer
- Principal Investigator
  
  Niimi Atsuko
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Fujita Health University
The understanding of the regulatory mechanisms how MYMLR regulates MYCPrincipal Investigator
- Principal Investigator
  
  Kajino Taisuke
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagoya University
Integrative analysis of lineage-survival signaling in lung adenocarcinoma
- Principal Investigator
  
  Takahashi Takashi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Tumor biology
- Research Institution
  Aichi Cancer Center Research Institute
  Nagoya University
Systems analysis of roles of non-coding RNAs in lung cancer development
- Principal Investigator
  
  Takahashi Takashi
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Aichi Cancer Center Research Institute
  Nagoya University

All 2023 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Long non-coding RNA TILR constitutively represses TP53 and apoptosis in lung cancer2023
- Author(s)
  Iwai Mika、Kajino Taisuke、Nakatochi Masahiro、Yanagisawa Kiyoshi、Hosono Yasuyuki、Isomura Hisanori、Shimada Yukako、Suzuki Motoshi、Taguchi Ayumu、Takahashi Takashi
- Journal Title
  
  Oncogene
  
  Volume: 42 Issue: 5 Pages: 364-373
- DOI
  10.1038/s41388-022-02546-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07679, KAKENHI-PROJECT-21K06565
[Journal Article] CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation2021
- Author(s)
  Hanxiao Sh, Atsuko Niimi, Toshiyuki Takeuchi, Kazuya Shiogama, Yasuyoshi Mizutani, Taisuke Kajino, Kenichi Inada, Tetsunari Hase, Takahiro Hatta, Hirofumi Shibata, Takayuki Fukui, Toyofumi Fengshi Chen-Yoshikawa, Kazuki Nagano, Takashi Murate, Yoshiyuki Kawamoto, Shuta Tomida, Takashi Takahashi, Motoshi Suzuki
- Journal Title
  
  Cancer Science
  
  Volume: 未定 Issue: 7 Pages: 2770-2780
- DOI
  10.1111/cas.14928
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07030, KAKENHI-PROJECT-18K07193, KAKENHI-PROJECT-16H02468, KAKENHI-PROJECT-18H02698, KAKENHI-PROJECT-20H03771
[Journal Article] Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator2021
- Author(s)
  Hisanori Isomura, Ayumu Taguchi, Taisuke Kajino, Naoya Asai, Masahiro Nakatochi, Seiichi Kato, Keiko Suzuki, Kiyoshi Yanagisawa, Motoshi Suzuki, Teruaki Fujishita, Tomoya Yamaguchi, Masahide Takahashi, Takashi Takahashi
- Journal Title
  
  Cancer Sci.
  
  Volume: 112 Issue: 4 Pages: 1614-1623
- DOI
  10.1111/cas.14825
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07440, KAKENHI-PROJECT-16H02468, KAKENHI-PROJECT-18H02698
[Journal Article] Inhibition of HSP90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma.2021
- Author(s)
  Khaledian B, Taguchi A, Shin-ya, K, Kondo-Ida L, Kagaya N, Suzuki M, Kajino T, Yamaguchi T, Shimada Y, Takahashi T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 112 Issue: 3 Pages: 1225-1234
- DOI
  10.1111/cas.14786
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02468, KAKENHI-PROJECT-18H02698, KAKENHI-PROJECT-20K18902, KAKENHI-PROJECT-19K07679
[Journal Article] Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction2019
- Author(s)
  Kajino T, Shimamura T, Gong S, Yanagisawa K, Ida L, Nakatochi M, Griesing S, Shimada Y, Kano K, Suzuki M, Miyano S
- Journal Title
  
  EMBO J
  
  Volume: 38 Issue: 17 Pages: 1-13
- DOI
  10.15252/embj.201798441
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08174, KAKENHI-PLANNED-15H05910, KAKENHI-PLANNED-15H05912, KAKENHI-PUBLICLY-18H04798, KAKENHI-PUBLICLY-19H05210, KAKENHI-PROJECT-18H02698
[Journal Article] ROR1-CAVIN3 interaction required for caveolae-dependent endocytosis and pro-survival signaling in lung adenocarcinoma2019
- Author(s)
  Yamaguchi T, Hayashi M, Ida L, Yamamoto M, Lu C, Kajino T, Cheng J, Nakatochi M, Isomura H, Yamazaki M, Suzuki M, Fujimoto T, Takahashi T.
- Journal Title
  
  Oncogene
  
  Volume: - Issue: 26 Pages: 5142-5157
- DOI
  10.1038/s41388-019-0785-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02468, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05910, KAKENHI-PROJECT-18H02683, KAKENHI-PROJECT-18H02698, KAKENHI-PROJECT-26290051
[Journal Article] Thyroid transcription factor-1-regulated miR-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma cells2017
- Author(s)
  Griesing, S, Kajino T, Tai MC, Liu Z, Nakatochi M, Shimada Y, Suzuki M, Takahashi T
- Journal Title
  
  Cancer Sci
  
  Volume: 108 Issue: 7 Pages: 1394-1404
- DOI
  10.1111/cas.13271
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05910, KAKENHI-PROJECT-26290051, KAKENHI-PROJECT-16K19050, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H02468
[Journal Article] TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.2016
- Author(s)
  Liu Z, Yanagisawa K, Griesing S, Iwai M, Kano K, Hotta N, Kajino T, Suzuki M, and Takahashi T.
- Journal Title
  
  Oncogene
  
  Volume: 524 Issue: 26 Pages: 1-9
- DOI
  10.1038/onc.2016.524
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293191, KAKENHI-PROJECT-25640076, KAKENHI-PROJECT-16H06277, KAKENHI-PLANNED-15H05910, KAKENHI-PROJECT-16H02468
[Journal Article] Receptor tyrosine kinase-like orphan receptor 1, a target of NKX2-1/TTF-1 lineage-survival oncogene, inhibits apoptosis signal-regulating kinase 1-mediated pro-apoptotic signaling in lung adenocarcinoma2016
- Author(s)
  Ida L, Yamaguchi T, Yanagisawa K, Kajino T, Shimada Y, Suzuki M, Takahashi T
- Journal Title
  
  Cancer Sci
  
  Volume: 107 Issue: 2 Pages: 155-161
- DOI
  10.1111/cas.12858
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670625, KAKENHI-PROJECT-25293191, KAKENHI-PROJECT-26290051, KAKENHI-PROJECT-25250017, KAKENHI-PLANNED-15H05910
[Journal Article] miR-342-3p regulates MYC transcriptional activity via direct repression of E2F1 in human lung cancer.2015
- Author(s)
  Tai MC, Kajino T, Nakatochi M, Arima C, Shimada Y, Suzuki M, Miyoshi H, Yatabe Y, Yanagisawa K, Takahashi T.
- Journal Title
  
  Carcinogenesis
  
  Volume: 36 Pages: 1464-1473
- DOI
  10.1093/carcin/bgv152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640076, KAKENHI-PROJECT-26670625, KAKENHI-PROJECT-26290051, KAKENHI-PROJECT-25250017, KAKENHI-PLANNED-15H05910
[Presentation] A novel long non-coding RNA, TILR, suppresses the apoptosis by inhibiting p53 expression.2020
- Author(s)
  Kajino T, Takahashi T
- Organizer
  第79回日本癌学会学術総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07679
[Presentation] A novel long non-coding RNA, TILR, suppresses apoptosis by inhibiting p53 expression.2020
- Author(s)
  Kajino T, Takahashi T
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H02468
[Presentation] システム生物学的な探索によるMYC制御lncRNA、MYMLRの同定と機能解明2019
- Author(s)
  Kajino T, Shimamura T, Gong S, Yanagisawa K, Ida L, Nakatochi M, Griesing S, Shimada Y, Kano K, Suzuki M, Miyano S, Takahashi T
- Organizer
  第４２回日本分子生物学会
- Data Source
  KAKENHI-PLANNED-15H05910
[Presentation] SRC is involved in the ROR1-sustained ASK1 inhibition2018
- Author(s)
  Lisa Ida, Tomoya Yamaguchi, Taisuke Kajino, Xiaoyi Shi, Miyuu Hayashi, Kiyoshi Yanagisawa, Yukako Shimada, Motoshi Suzuki, and Takashi Takahashi
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H02468
[Presentation] Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction2018
- Author(s)
  Taisuke Kajino, Teppei Shimamura, Shuyi Gong, Kiyoshi Yanagisawa, Masahiro Nakatochi, Sebastian Griesing, Yukako Shimada, Keiko Kano, Motoshi Suzuki, Satoru Miyano, Takashi Takahashi
- Organizer
  Keystone Symposia "DNA and RNA methylation"
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05910
[Presentation] ROR1-CAVIN3 interaction required for caveolae-dependent endocytosis and pro-survival signaling in lung adenocarcinoma.2018
- Author(s)
  Tomoya Yamaguchi, Miyu Hayashi, Lisa Ida, Can Lu, Taisuke Kajino, Jinglei Cheng, Hisanori Isomura, Motoshi Suzuki, Toyoshi Fujimoto, Takashi Takahashi.
- Organizer
  第77回日本癌学会総会
- Data Source
  KAKENHI-PLANNED-15H05910
[Presentation] SRC is involved in the ROR1-sustained ASK1 inhibition.2018
- Author(s)
  Lisa Ida, Tomoya Yamaguchi, Taisuke Kajino, Xiaoyi Shi, Miyuu Hanashi, Kiyoshi Yanagisawa, Yukako Shimada, Motoshi Suzuki, Takashi Takahashi
- Organizer
  第77回日本癌学会総会
- Data Source
  KAKENHI-PLANNED-15H05910
[Presentation] Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction2018
- Author(s)
  Taisuke Kajino, Teppei Shimamura, Shuyi Gong, Kiyoshi Yanagisawa, Masahiro Nakatochi, Sebastian Griesing, Yukako Shimada, Keiko Kano, Motoshi Suzuki, Satoru Miyano, Takashi Takahashi
- Organizer
  Keystone Symposia "DNA and RNA methylation"
- Data Source
  KAKENHI-PROJECT-16H02468
[Presentation] 肺腺がんでのROR1によるカベオラ依存的エンドサイトーシスを介した生存シグナル制御機構2018
- Author(s)
  山口知也、林美優、井田梨沙、Can Lu、梶野泰祐、Jinglei Cheng、磯村久徳、鈴木元、藤本豊士、高橋隆
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H02468
[Presentation] Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction2018
- Author(s)
  Taisuke Kajino, Teppei Shimamura, Shuyi Gong, Kiyoshi Yanagisawa, Masahiro Nakatochi, Sebastian Griesing, Yukako Shimada, Keiko Kano, Motoshi Suzuki, Satoru Miyano, Takashi Takahashi
- Organizer
  AACR Annual Meeting 2018
- Data Source
  KAKENHI-PROJECT-16H02468
[Presentation] Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction.2018
- Author(s)
  Kajino T, Shimamura T, Gong S, Yanagisawa K, Nakatochi M, Griesing S, Shimada Y, Kano K, Suzuki M, Miyano S, Takahashi T
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05910
[Presentation] Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction2017
- Author(s)
  Taisuke Kajino, Teppei Shimamura, Shuyi Gong, Kiyoshi Yanagisawa, Masahiro Nakatochi, Sebastian Griesing, Yukako Shimada, Keiko Kano, Motoshi Suzuki, Satoru Miyano, Takashi Takahashi
- Organizer
  Keystone Symposia, DNA and RNA methylation
- Data Source
  KAKENHI-PROJECT-16K19050
[Presentation] ROR1によるカベオラ形成と生存シグナルの維持機構2017
- Author(s)
  山口知也、林美優、井田梨沙、Can Lu、梶野泰祐、Jinglei Cheng、磯村久徳、鈴木元、藤本豊士、高橋隆
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PLANNED-15H05910
[Presentation] Systems biology-based identification of MYMLR lncRNA modulating MYC oncogene2017
- Author(s)
  Taisuke Kajino, Teppei Shimamura, Gong Shuyi, Kiyoshi Yanagisawa, Masahiro Nakatochi, Sebastian Griesing , Yukako Shimada, Keiko Kano, Satoru Miyano, Takashi Takahashi
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-15H05910
[Presentation] Systems biology-based identification of MYMLR lncRNA modulating MYC oncogene2017
- Author(s)
  Taisuke Kajino, Teppei Shimamura, Gong Shuyi, Kiyoshi Yanagisawa, Masahiro Nakatochi, Sebastian Griesing , Yukako Shimada, Keiko Kano, Satoru Miyano, Takashi Takahashi
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H02468
[Presentation] Systems biology-based identification of MYMLR lncRNA modulating MYC oncogene2017
- Author(s)
  Taisuke Kajino, Teppei Shimamura, Gong Shuyi, Kiyoshi Yanagisawa, Masahiro Nakatochi, Sebastian Griesing , Yukako Shimada, Keiko Kano, Satoru Miyano, Takashi Takahashi
- Organizer
  Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-16K19050
[Presentation] ROR1 inhibits ASK1-mediated pro-apoptotic signaling in lung adenocarcinoma2017
- Author(s)
  Lisa Ida, Tomoya Yamaguchi, Taisuke Kajino, Kiyoshi Yanagisawa, Yukako Shimada, Motoshi Suzuki, and Takashi Takahashi
- Organizer
  AACR Annual Meeting 2017
- Data Source
  KAKENHI-PROJECT-16H02468
[Presentation] ROR1によるカベオラ形成と生存シグナルの維持機構2017
- Author(s)
  山口知也、林美優、井田梨沙、Can Lu、梶野泰祐、Jinglei Cheng、磯村久徳、鈴木元、藤本豊士、高橋隆
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-16H02468
[Presentation] ROR1 inhibits ASK1-mediated pro-apoptotic signaling in lung adenocarcinoma2017
- Author(s)
  Lisa Ida, Tomoya Yamaguchi, Taisuke Kajino, Kiyoshi Yanagisawa, Yukako Shimada, Motoshi Suzuki, and Takashi Takahashi
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05910

1. Takahashi Takashi (50231395)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
2. Niimi Atsuko (50508984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 細野祥之 (60820363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 中杤昌弘 (10559983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. 柳澤聖 (20372112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
6. 長田啓隆 (30204176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 宮野悟 (50128104)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 山口知也 (70452191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. 松下博和 (80597782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIOGAMA Kazuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. MIZUTANI Yasuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. FUJISHITA Teruaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 鈴木元

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 稲田健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAJINO TAISUKE 梶野 泰祐

Kajino Taisuke 梶野 泰祐

Research Projects

Research Products

Co-Researchers

がん特異的にp53を制御するlncRNAの分子機構の解明とがんの生存戦略の理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of molecular mechanisms how TILR regulates apoptosis in lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of gene module for genomic instability in lung cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The understanding of the regulatory mechanisms how MYMLR regulates MYCPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Integrative analysis of lineage-survival signaling in lung adenocarcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Systems analysis of roles of non-coding RNAs in lung cancer development

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Long non-coding RNA TILR constitutively represses TP53 and apoptosis in lung cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of HSP90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter-enhancer interaction2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ROR1-CAVIN3 interaction required for caveolae-dependent endocytosis and pro-survival signaling in lung adenocarcinoma2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thyroid transcription factor-1-regulated miR-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.2016

Author(s)

Journal Title

DOI

KAJINO TAISUKE 梶野泰祐

Kajino Taisuke 梶野泰祐