Yoko Yagishita 柳下陽子

Researcher Number	50733838
Affiliation (based on the past Project Information) *help	2016: 東北大学, 医学(系)研究科(研究院), 非常勤講師 2016: 東北大学, 大学院医学系研究科, 研究員 2014 – 2015: 東北大学, 医学(系)研究科(研究院), 産学官連携研究員
Review Section/Research Field	Principal Investigator Pathological medical chemistry Except Principal Investigator Pathological medical chemistry
Keywords	Principal Investigator 生体分子 / 糖尿病 / Nrf2 / ストレス / 肥満 / 脂肪炎症 / 酸化ストレス / 遺伝子改変 / 膵β細胞 Except Principal Investigator 膵β細胞 … More / 視床下部 / Keap1 / レプチン抵抗性 / インスリン抵抗性 / 代謝学 / セレノシステイン / Nrf2 / 酸化ストレス / 肥満 / 糖尿病 Less

Keap1-Nrf2系による肥満脂肪組織における炎症制御機構の解明Principal Investigator
- Principal Investigator
  
  柳下陽子
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
The role of Nrf2 in pancreatic beta-cells; a study of new pancreatic beta-cell specific Nrf2 activation model micePrincipal Investigator
- Principal Investigator
  
  Yoko Yagishita
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
The role of Nrf2 in oxidative stress-mediated insulin resistance
- Principal Investigator
  
  Akira Uruno
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University

All 2017 2016 2015 2014 Other

All Journal Article Presentation Book Other

[Book] Molecular Nutrition and Diabetes. Section 3, 34. Nrf2-mediated gene regulations and glucose homeostasis2015
- Author(s)
  Yoko Yagishita, Akira Uruno, Masayuki Yamamoto
- Publisher
  Elsevier.B.V.
- Data Source
  KAKENHI-PROJECT-26893008
[Book] Molecular Nutrition and Diabetes, 1st Edition.2015
- Author(s)
  Yagishita Y, Uruno A, Yamamoto M
- Total Pages
  400
- Publisher
  Elsevier Science B.V.
- Data Source
  KAKENHI-PROJECT-26460383
[Book] Molecular Nutrition and Diabetes2015
- Author(s)
  Yagishita Y, Uruno A and Yamamoto M.
- Total Pages
  400
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26893008
[Journal Article] The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice.2017
- Author(s)
  Higashi C, Kawaji A, Tsuda N, Hayashi M, Saito R, Yagishita Y, Suzuki T, Uruno A, Nakamura M, Nakao K, Furusako S, Yamamoto M.
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 802 Pages: 76-84
- DOI
  10.1016/j.ejphar.2017.02.044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26460354, KAKENHI-PROJECT-26460383, KAKENHI-PROJECT-16K19046, KAKENHI-PROJECT-17K01837, KAKENHI-PROJECT-17K15590
[Journal Article] Nrf2-mediated regulation of skeletal muscle glycogen metabolism.2016
- Author(s)
  Uruno A, Yagishita Y, Katsuoka F, Kitajima Y, Nunomiya A, Nagatomi R, Pi J, Biswal SS, Yamamoto M.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 36
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460383
[Journal Article] Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism.2016
- Author(s)
  Uruno A, Yagishita Y, Katsuoka F, Kitajima Y, Nunomiya A, Nagatomi R, Pi J, Biswal SS, Yamamoto M.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 36 Issue: 11 Pages: 1655-1672
- DOI
  10.1128/mcb.01095-15
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16J00431, KAKENHI-PROJECT-26460383, KAKENHI-PROJECT-16K19046, KAKENHI-PROJECT-15K16486
[Journal Article] Nrf2-mediated regulation of skeletal muscle glycogen metabolism.2016
- Author(s)
  Uruno A, Yagishita Y, Katsuoka F, Kitajima Y, Nunomiya A, Nagatomi R, Pi J, Biswal S and Yamamoto M
- Journal Title
  
  Mol Cell Biol
  
  Volume: 36
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893008
[Journal Article] The Keap1-Nrf2 system and diabetes mellitus.2015
- Author(s)
  Uruno A, Yagishita Y, Yamamoto M.
- Journal Title
  
  Arch Biochem Biophys.
  
  Volume: 566 Pages: 76-84
- DOI
  10.1016/j.abb.2014.12.012
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460383, KAKENHI-PROJECT-26893008, KAKENHI-PLANNED-26111002
[Journal Article] Effects of RXR agonists on cell proliferation/apoptosis and ACTH secretion/Pomc expression2015
- Author(s)
  Saito-Hakoda A, Uruno A, Yokoyama A, Shimizu K, Parvin R, Kudo M, Saito-Ito T, Sato I, Kogure N, Suzuki D, Shimada H, Yoshikawa T, Fujiwara I, Kagechika H, Iwasaki Y, Kure S, Ito S, Sugawara A
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 12 Pages: e0141960-e0141960
- DOI
  10.1371/journal.pone.0141960
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09420, KAKENHI-PROJECT-26460383, KAKENHI-PROJECT-25461381, KAKENHI-PROJECT-26830041
[Journal Article] Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice.2014
- Author(s)
  Hirotsu Y, Higashi C, Fukutomi T, Katsuoka F, Tsujita T, Yagishita Y, Matsuyama Y, Motohashi H, Uruno A, and Yamamoto M.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 19 Issue: 8 Pages: 650-665
- DOI
  10.1111/gtc.12165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-25750357, KAKENHI-PROJECT-26460383, KAKENHI-PROJECT-26670150, KAKENHI-PROJECT-26893008
[Journal Article] Retinoic acid receptor-α up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells2014
- Author(s)
  Uruno, A.; Saito-Hakoda, A.; Yokoyama, A.; Kogure, N.; Matsuda, K.; Parvin, R.; Shimizu, K.; Sato, I.; Kudo, M.; Yoshikawa, T.; Kagechika, H.; Iwasaki, Y.; Ito, S.; Sugawara, A.
- Journal Title
  
  Endocr J
  
  Volume: 61 Issue: 11 Pages: 1105-1114
- DOI
  10.1507/endocrj.EJ14-0115
- NAID
  130004677954
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136013, KAKENHI-PROJECT-26460383
[Journal Article] Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells.2014
- Author(s)
  Matsuda K, Uruno A, Kogure N, Sugawara K, Shimada H, Nezu M, Saito-Ito T, Iki Y, Kudo M, Shimizu K, Sato I, Yoshikawa T, Satoh F, Ito R, Yokoyama A, Rainey WE, Saito-Hakoda A, Ito S, Sugawara A.
- Journal Title
  
  Mol Cell Endocrinol.
  
  Volume: 383(1-2) Issue: 1-2 Pages: 60-68
- DOI
  10.1016/j.mce.2013.12.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24658091, KAKENHI-PROJECT-24790306, KAKENHI-PROJECT-25461381, KAKENHI-PROJECT-26460383
[Journal Article] Nrf2 induces fibroblast growth factor 21 in diabetic mice2014
- Author(s)
  Furusawa Y, Uruno A, Yagishita Y, Higashi C, and Yamamoto M.
- Journal Title
  
  Genes Cells
  
  Volume: 19 Issue: 12 Pages: 864-878
- DOI
  10.1111/gtc.12186
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249015, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26460383, KAKENHI-PROJECT-26893008
[Presentation] Nrf2によるグリコーゲン分枝鎖酵素遺伝子発現制御機構の解明2016
- Author(s)
  相川享、宇留野晃、柳下陽子、山本雅之
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台（仙台国際センター）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26460383
[Presentation] 糖尿病におけるKeap1-Nrf2系の役割「日本糖尿病学会共催シンポジウム　病気と生化学：個体レベルでの糖代謝調節機構と糖尿病」2016
- Author(s)
  宇留野晃、柳下陽子、山本雅之
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター、宮城
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K19046
[Presentation] 糖尿病におけるKeap1-Nrf2系の役割2016
- Author(s)
  宇留野晃、柳下陽子、山本雅之
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台（仙台国際センター）
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-26460383
[Presentation] Nrf2によるグリコーゲン分枝鎖酵素遺伝子発現制御機構の解明2016
- Author(s)
  相川享、宇留野晃、柳下陽子、山本雅之
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター、宮城
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K19046
[Presentation] 骨格筋におけるNrf2のグリコーゲン代謝制御機構2015
- Author(s)
  宇留野晃、柳下陽子、山本雅之
- Organizer
  第３８回日本分子生物学会年会　第８８回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド（神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26893008
[Presentation] Keap1-Nrf2システムによるTrsp欠失マウス膵β細胞および視床下部の酸化ストレス防御機構2015
- Author(s)
  柳下陽子、福富俊明、宇留野晃、山本雅之
- Organizer
  第38回分子生物学会/第88回日本生化学会大会合同大会(BMB2015)
- Place of Presentation
  神戸 (神戸ポートアイランド)
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26460383
[Presentation] Nrf2 regulates glycogen metabolism in skeletal muscle.2015
- Author(s)
  Uruno A, Yagishita Y, Yamamoto M.
- Organizer
  The Keap1/Nrf2 Pathway in Health and Disease
- Place of Presentation
  Cambridge (Robinson College)
- Year and Date
  2015-01-07
- Data Source
  KAKENHI-PROJECT-26460383
[Presentation] Keap1-Nrf2システムによるTrsp欠失マウス膵β細胞および視床下部の酸化ストレス防御機構2015
- Author(s)
  柳下陽子、福富俊明、宇留野晃、山本雅之
- Organizer
  第３８回日本分子生物学会年会　第８８回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド（神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26893008
[Presentation] Nrf2 regulates glucose metabolism-related genes.2015
- Author(s)
  Yagishita Y, Uruno A, Katsuoka F, Funayama R, Nakayama K, Yamamoto M.
- Organizer
  The Keap1/Nrf2 Pathway in Health and Disease
- Place of Presentation
  Cambridge (Robinson College)
- Year and Date
  2015-01-07
- Data Source
  KAKENHI-PROJECT-26460383
[Presentation] Nrf2 regulates glucose metabolism-related genes.2015
- Author(s)
  Yoko Yagishita, Akira Uruno, Fumiki Katsuoka, Thomas Kensler, Masayuki Yamamoto
- Organizer
  27th Annual UPCI Scientific Retreat
- Place of Presentation
  Pittsburgh, USA
- Year and Date
  2015-06-18
- Data Source
  KAKENHI-PROJECT-26893008
[Presentation] 骨格筋におけるNrf2のグリコーゲン代謝制御機構2015
- Author(s)
  宇留野晃、柳下陽子、山本雅之
- Organizer
  第88回日本生化学会大会合同大会(BMB2015)
- Place of Presentation
  神戸 (神戸ポートアイランド)
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26460383
[Presentation] Nrf2 regulates glucose metabolism-related genes2015
- Author(s)
  Yagishita Y, Uruno A, Katsuoka F, Funayama R, Nakayama K, Kensler TW, Yamamoto M.
- Organizer
  27th Annyal UPCI Scientific Retreat
- Place of Presentation
  Pittsburgh (アメリカ合衆国)
- Year and Date
  2015-06-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460383
[Presentation] Nrf2による糖尿病の発症抑制作用2014
- Author(s)
  宇留野晃、古澤祐樹、柳下陽子、山本雅之
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都（国立京都国際会館）
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-26460383
[Presentation] Keap1-Nrf2システムは糖尿病発症を抑制する2014
- Author(s)
  宇留野晃、古澤祐樹、柳下陽子、福富俊明、山本雅之
- Organizer
  第80回日本生化学会東北支部例会
- Place of Presentation
  秋田（アキタパークホテル）
- Year and Date
  2014-05-10
- Data Source
  KAKENHI-PROJECT-26460383
[Presentation] Nrf2による酸化ストレス糖尿病モデルマウスの膵β細胞保護2014
- Author(s)
  柳下陽子、宇留野晃、福富俊明、菅原明、山本雅之
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都（国立京都国際会館）
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-26460383
[Presentation] Nrf2による糖尿病の発症抑制作用
- Author(s)
  宇留野晃、古澤祐樹、柳下陽子、山本雅之
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府、京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26893008
[Presentation] Nrf2 regulates glycogen metabolism in skeletal muscle
- Author(s)
  Akira Uruno, Yoko Yagishita, Masayuki Yamamoto
- Organizer
  The Keap1/Nrf2 Pathway in Health and Disease
- Place of Presentation
  Cambridge, UK
- Year and Date
  2015-01-06 – 2015-01-08
- Data Source
  KAKENHI-PROJECT-26893008
[Presentation] Nrf2 regulates glucose metabolism-related genes
- Author(s)
  Yoko Yagishita, Akira Uruno, Fumiki Katsuoka, Ryo Funayama, Keiko Nakayama, Masayuki Yamamoto
- Organizer
  The Keap1/Nrf2 Pathway in Health and Disease
- Place of Presentation
  Cambridge, UK
- Year and Date
  2015-01-06 – 2015-01-08
- Data Source
  KAKENHI-PROJECT-26893008
[Presentation] Nrf2による酸化ストレス糖尿病モデルマウスの膵β細胞保護
- Author(s)
  柳下陽子、宇留野晃、福富俊明、菅原明、山本雅之
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府、京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26893008
[]

1. URUNO Akira (90396474)

# of Collaborated Projects: 2 results

# of Collaborated Products: 24 results
2. YAMAMOTO Masayuki (50166823)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
3. NAGANUMA Eriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. DATE Fumiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YOKOYAMA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. SUZUKI Norio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. HAKODA Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 本橋ほづみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 菅原明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yoko Yagishita 柳下 陽子

Research Projects

Research Products

Co-Researchers

Keap1-Nrf2系による肥満脂肪組織における炎症制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of Nrf2 in pancreatic beta-cells; a study of new pancreatic beta-cell specific Nrf2 activation model micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of Nrf2 in oxidative stress-mediated insulin resistance

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Molecular Nutrition and Diabetes. Section 3, 34. Nrf2-mediated gene regulations and glucose homeostasis2015

Author(s)

Publisher

Data Source

[Book] Molecular Nutrition and Diabetes, 1st Edition.2015

Author(s)

Total Pages

Publisher

Data Source

[Book] Molecular Nutrition and Diabetes2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nrf2-mediated regulation of skeletal muscle glycogen metabolism.2016

Author(s)

Journal Title

Data Source

[Journal Article] Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nrf2-mediated regulation of skeletal muscle glycogen metabolism.2016

Author(s)

Journal Title

Data Source

[Journal Article] The Keap1-Nrf2 system and diabetes mellitus.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of RXR agonists on cell proliferation/apoptosis and ACTH secretion/Pomc expression2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Retinoic acid receptor-&alpha; up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells2014

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells.2014

Author(s)

Journal Title

Yoko Yagishita 柳下陽子

[Journal Article] Retinoic acid receptor-α up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells2014

[Presentation] 糖尿病におけるKeap1-Nrf2系の役割「日本糖尿病学会共催シンポジウム　病気と生化学：個体レベルでの糖代謝調節機構と糖尿病」2016