Sanada Yu 真田悠生

Researcher Number	50738656
Other IDs
Affiliation (Current)	2025: 京都大学, 複合原子力科学研究所, 助教
Affiliation (based on the past Project Information) *help	2017 – 2024: 京都大学, 複合原子力科学研究所, 助教 2015 – 2016: 京都大学, 原子炉実験所, 助教
Review Section/Research Field	Except Principal Investigator Basic Section 63020:Radiation influence-related / Basic Section 90120:Biomaterials-related / Basic Section 52040:Radiological sciences-related / Tumor biology
Keywords	Except Principal Investigator 中性子捕捉療法 / ホウ素中性子捕捉療法 / 腫瘍内微小環境 / 休止期腫瘍細胞 / ビグアノイド薬剤 / 細胞内微細環境 / DNA損傷修復 / デンドリマー / EGFR / ドラッグデリバリー … More / ＤＤＳ / 担がんマウス / インビボイメージング / 抗体 / ドラッグデリバリーシステム / 体内動態 / 腫瘍増殖抑制効果 / 腫瘍集積 / 二重特異性抗体 / 放射線損傷からの回復現象 / 低酸素細胞毒 / 低温度温熱処置 / 低酸素誘導因子 / 放射線障害からの回復現象 / 腫瘍不均一性, / p53 status / 化合物生物学的効果比 / 温熱治療 / 癌幹細胞性 / 腫瘍不均一性 / 遠隔転移抑制能 / 急性低酸素領域 / ピモニダゾール / ティラパザミン / 低グルコース環境 / メトフォルミン / HIF-1α / ゲノム編集技術 / 転移能抑制 / 局所腫瘍制御 / がん微小環境 / 線量率効果 / CBE値 / 硼素中性子捕捉療法 / 放射線治療生物学 / ゲノム改変操作 / 転移 Less

Biguanide系薬剤Metforminの腫瘍内環境特性による細胞致死と抗腫瘍免疫誘導の解析
- Principal Investigator
  
  田野恵三
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Osaka Metropolitan University
Interrelationship analysis of the characteristics of quiescent tumor cells with tumor heterogeneity and cancer stem cell nature, referring to application to cancer therapy
- Principal Investigator
  
  増永慎一郎
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Osaka Metropolitan University
  Osaka Prefecture University
  Kyoto University
Development of BNCT Boron Delivery System by Using Bispecific Antibody
- Principal Investigator
  
  Nagasaki Takeshi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Osaka Metropolitan University
  Osaka City University
An attempt to achieve both controlling local tumors and repressing distant metastases through exploiting analytical findings concerning characteristics of intratumor microenvironment
- Principal Investigator
  
  Masunaga Shin-ichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Phospholipid‐Coated Boronic Oxide Nanoparticles as a Boron Agent for Boron Neutron Capture Therapy2023
- Author(s)
  Kawasaki Riku、Hirano Hidetoshi、Yamana Keita、Oshige Ayano、Nishimura Kotaro、Kono Nanami、Sanada Yu、Bando Kaori、Tabata Anri、Yasukawa Naoki、Azuma Hideki、Takata Takushi、Sakurai Yoshinori、Tanaka Hiroki、Suzuki Minoru、Tarutani Naoki、Katagiri Kiyofumi、Nagasaki Takeshi、Ikeda Atsushi
- Journal Title
  
  ChemBioChem
  
  Volume: - Issue: 15
- DOI
  10.1002/cbic.202300186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H04472, KAKENHI-PROJECT-23K17918, KAKENHI-PROJECT-22K18196, KAKENHI-PROJECT-22KJ2337
[Journal Article] Correction: Imamichi et al. Extracellular Release of HMGB1 as an Early Potential Biomarker for the Therapeutic Response in a Xenograft Model of Boron Neutron Capture Therapy. Biology 2022, 11, 4202023
- Author(s)
  Imamichi Shoji、Chen Lichao、Ito Tasuku、Tong Ying、Onodera Takae、Sasaki Yuka、Nakamura Satoshi、Mauri PierLuigi、Sanada Yu、Igaki Hiroshi、Murakami Yasufumi、Suzuki Minoru、Itami Jun、Masunaga Shinichiro、Masutani Mitsuko
- Journal Title
  
  Biology
  
  Volume: 12 Issue: 8 Pages: 1112-1112
- DOI
  10.3390/biology12081112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08171
[Journal Article] Carborane bearing pullulan nanogel-boron oxide nanoparticle hybrid for boron neutron capture therapy2023
- Author(s)
  Kawasaki Riku、Hirano Hidetoshi、Yamana Keita、Isozaki Hinata、Kawamura Shogo、Sanada Yu、Bando Kaori、Tabata Anri、Yoshikawa Kouhei、Azuma Hideki、Sasaki Yoshihiro、Akiyoshi Kazunari、Nagasaki Takeshi、Ikeda Atsushi
- Journal Title
  
  Nanomedicine: Nanotechnology, Biology and Medicine
  
  Volume: 49 Pages: 102659-102659
- DOI
  10.1016/j.nano.2023.102659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K18196, KAKENHI-PROJECT-19H04472, KAKENHI-PROJECT-22KJ2337, KAKENHI-PROJECT-21K18324
[Journal Article] The impact of TP53 status of tumor cells including the type and the concentration of administered 10B delivery agents on compound biological effectiveness in boron neutron capture therapy.2023
- Author(s)
  Masunaga S, Sanada Y, Takata T, Tanaka H, Sakurai Y, Suzuki M, Kirihata M, Ono K.
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 64(2) Issue: 2 Pages: 399-411
- DOI
  10.1093/jrr/rrad001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08171, KAKENHI-PROJECT-19K08134
[Journal Article] Extracellular Release of HMGB1 as an Early Potential Biomarker for the Therapeutic Response in a Xenograft Model of Boron Neutron Capture Therapy2022
- Author(s)
  Imamichi Shoji、Chen Lichao、Ito Tasuku、Tong Ying、Onodera Takae、Sasaki Yuka、Nakamura Satoshi、Mauri PierLuigi、Sanada Yu、Igaki Hiroshi、Murakami Yasufumi、Suzuki Minoru、Itami Jun、Masunaga Shinichiro、Masutani Mitsuko
- Journal Title
  
  Biology
  
  Volume: 11 Issue: 3 Pages: 420-420
- DOI
  10.3390/biology11030420
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17218, KAKENHI-PROJECT-20K16810, KAKENHI-PROJECT-19K08171
[Journal Article] Solbilization of All-Trans-Retinoic Acid as Macrophage Polarizer by beta-1,3-Glucan2022
- Author(s)
  Yasukawa Naoki, Bando Kaori, Tabata Anri, Miyao Hayato, Kawasaki Riku, Sanada Yu, Kondo Natsuko, Nagasaki Takeshi
- Journal Title
  
  KURNS Progress Report 2021
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-19H04472
[Journal Article] Cancer-Targeting Hyaluronic Acid/Carboranyl Pyrene Complex for Boron Neutron Capture Therapy2021
- Author(s)
  Keita Yamana, Riku Kawasaki, Yu Sanada, Shin-ichiro Masunaga, Minoru. Suzuki, Yoshinori Sakurai, Anri Tabata, Kaori Bando, Kohei Yoshikawa, kouta Sugikawa, Takeshi Nagasaki, and Atsushi Ikeda
- Journal Title
  
  KURNS Progress Report 2020
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-19H04472
[Journal Article] HIF-1α affects sensitivity of murine squamous cell carcinoma to boron neutron capture therapy with BPA.2021
- Author(s)
  Sanada Y, Takata T, Tanaka H, Sakurai Y, Watanabe T, Suzuki M, Masunaga S.
- Journal Title
  
  International Journal of Radiation Biology
  
  Volume: 97 Issue: 10 Pages: 1441-1449
- DOI
  10.1080/09553002.2021.1956004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08171
[Journal Article] Tumor-targeting hyaluronic acid/fluorescent carborane complex for boron neutron capture therapy2021
- Author(s)
  Yamana Keita、Kawasaki Riku、Sanada Yu、Tabata Anri、Bando Kaori、Yoshikawa Kouhei、Azuma Hideki、Sakurai Yoshinori、Masunaga Shin-ichiro、Suzuki Minoru、Sugikawa Kouta、Nagasaki Takeshi、Ikeda Atsushi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 559 Pages: 210-216
- DOI
  10.1016/j.bbrc.2021.04.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K15401, KAKENHI-PROJECT-19H04472, KAKENHI-PROJECT-19K08171
[Journal Article] Preparation and Characterization of a Novel Bispecific Antibody That Targets Her2 and BSH for Boron Neutron Capture Therapy2020
- Author(s)
  Taisei Kanai, Taro Tachibana, Takeshi Nakanishi, Mitsunori Kirihata, Yoshihide Hattori, Yu Sanada, Yoshinori Sakurai, Shin-ichiro Masunaga
- Journal Title
  
  KURNS Progress Report 2019
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-19H04472
[Journal Article] An attempt to improve the therapeutic effect of boron neutron capture therapy using commonly employed 10B-carriers based on analytical studies on the correlation among quiescent tumor cell characteristics, tumor heterogeneity and cancer stemness2020
- Author(s)
  Shin-ichiro Masunaga, Yu Sanada, Keizo Tano, Yoshinori Sakurai, Hiroki Tanaka, Takushi Takata, Minoru Suzuki, Koji Ono
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 61 Issue: 6 Pages: 876-885
- DOI
  10.1093/jrr/rraa048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11640, KAKENHI-PROJECT-19K08134, KAKENHI-PROJECT-19K08171
[Journal Article] Usefulness of combination with both continuous administration of hypoxic cytotoxin and mild temperature hyperthermia in boron neutron capture therapy in terms of local tumor response and lung metastatic potential2019
- Author(s)
  Masunaga S, Sakurai Y, Tanaka H, Takata T, Suzuki M, Sanada Y, Tano K, Maruhashi A and Ono K
- Journal Title
  
  Int. J. Radiat. Biol.
  
  Volume: 95 Issue: 12 Pages: 1708-1717
- DOI
  10.1080/09553002.2019.1666214
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11640, KAKENHI-PROJECT-19K08171
[Journal Article] Design, Synthesis, and Evaluation of Lipopeptide Conjugates of Mercaptoundecahydrododecaborate for Boron Neutron Capture Therapy2019
- Author(s)
  Isono Aoi、Tsuji Mieko、Sanada Yu、Matsushita Akari、Masunaga Shinichiro、Hirayama Tasuku、Nagasawa Hideko
- Journal Title
  
  ChemMedChem
  
  Volume: 14 Issue: 8 Pages: 823-832
- DOI
  10.1002/cmdc.201800793
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05102, KAKENHI-PROJECT-15H04295, KAKENHI-PROJECT-19K08171
[Journal Article] Effects of p53 status of tumor cells and combined treatment with mild hyperthermia, wortmannin or caffeine on recovery from radiation-induced damage2019
- Author(s)
  Masunaga S, Tano K, Sanada Y, Suzuki M, Takahashi A, Ohnishi K and Ono K
- Journal Title
  
  World J. Oncol.
  
  Volume: 10 Issue: 3 Pages: 132-141
- DOI
  10.14740/wjon1203
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11640, KAKENHI-PROJECT-19K08171
[Journal Article] Disruption of Hif-1α enhances cytotoxic effects of metformin in murine squamous cell carcinoma.2018
- Author(s)
  Sanada Y, Sasanuma H, Takeda S, Tano K, Masunaga S.
- Journal Title
  
  Int J Radiat Biol
  
  Volume: 94 Issue: 1 Pages: 88-96
- DOI
  10.1080/09553002.2018.1409443
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04295, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-18K11640, KAKENHI-PROJECT-16H02953
[Journal Article] Effect of a change in reactor power on response of murine solid tumors in vivo, referring to impact on quiescent tumor cell population.2018
- Author(s)
  Masunaga S, Sakurai Y, Tanaka H, Takata T, Suzuki M, Sanada Y, Tano K, Maruhashi A, Ono K.
- Journal Title
  
  Int J Radiat Biol
  
  Volume: Dec 17 Issue: 5 Pages: 1-28
- DOI
  10.1080/09553002.2019.1558300
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04295, KAKENHI-PROJECT-18K11640, KAKENHI-PROJECT-19K08171
[Journal Article] The Effect of p53 Status on Radio-Sensitivity of Quiescent Tumor Cell Population Irradiated With γ-Rays at Various Dose Rates.2018
- Author(s)
  Masunaga S, Kobayashi J, Tano K, Sanada Y, Suzuki M, Ono K.
- Journal Title
  
  J Clin Med Res.
  
  Volume: 10 Issue: 11 Pages: 815-821
- DOI
  10.14740/jocmr3610w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04978, KAKENHI-PROJECT-15K00537, KAKENHI-PROJECT-15H04295
[Journal Article] Effect of Tirapazamine, Metformin or Mild Hyperthermia on Recovery from Radiation-Induced Damage in Pimonidazole-Unlabeled Quiescent Tumor Cells2017
- Author(s)
  Masunaga S, Tano K, Sanada Y, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Watanabe T, Takata T, Maruhashi A and Ono K
- Journal Title
  
  World J. Oncol.
  
  Volume: 8 Issue: 5 Pages: 137-146
- DOI
  10.14740/wjon1058w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00537, KAKENHI-PROJECT-15H04295
[Journal Article] Effect of oxygen pressure during incubation with a 10B-carrier on 10B uptake capacity of cultured p53 wild-type and mutated tumor cells: dependency on p53 status of tumor cells and types of 10B-carriers2016
- Author(s)
  Masunaga S, Tatebe H, Nishimura Y, Tano K, Sanada Y, Moriwaki T, Sakurai Y, Tanaka H, Suzuki M, Kondo N, Maruhashi A and Ono K
- Journal Title
  
  International Journal of Radiation Biology
  
  Volume: 92 Issue: 4 Pages: 187-194
- DOI
  10.3109/09553002.2016.1137104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K00537, KAKENHI-PROJECT-26670556, KAKENHI-PROJECT-15H04295, KAKENHI-PROJECT-24510072
[Journal Article] 腫瘍内環境とがん細胞増感の試み2015
- Author(s)
  真田悠生、森脇隆宏、田野恵三、増永慎一郎
- Journal Title
  
  放射線生物研究(Radiation Biology Research Communications)
  
  Volume: 50 Pages: 148-172
- NAID
  40020692187
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04295
[Journal Article] The effect of p53 status of tumor cells on radiosensitivity of irradiated tumors with carbon-ion beams compared with γ-rays or reactor neutron beams2015
- Author(s)
  Masunaga S, Uzawa A, Hirayama R, Matsumoto Y, Sakurai Y, Tanaka H, Tano K, Sanada Y, Suzuki M, Maruhashi A and Ono K
- Journal Title
  
  World J. Oncol.
  
  Volume: 6 Issue: 4 Pages: 398-409
- DOI
  10.14740/wjon941w
- NAID
  120006644056
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00537, KAKENHI-PROJECT-15K09986, KAKENHI-PROJECT-26670556, KAKENHI-PROJECT-15H04295, KAKENHI-PROJECT-24510072
[Presentation] 腫瘍特異的なアミノ酸輸送系を利用する中性子捕捉療法のための新規ホウ素キャリアの開発2023
- Author(s)
  新津明穂、山本凌大、真田悠生、渡邉翼、増永慎一郎、辻美恵子、平山佑、永澤秀子
- Organizer
  日本薬学会第143年会（札幌）
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] Bispecific antibody against BSH and Her2 for Boron Neutron Capture Therapy2023
- Author(s)
  T. Nagasaki, A. Tabata, T. Kanai, T. Tachibana, T. Nakanishi, R. Kawasaki, Y. Sakurai, Y. Sanada
- Organizer
  2023 Taiwan-Japan Neutron Capure Therapy Academic Conference of Elite
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04472
[Presentation] 二重特異性抗体を用いたBNCTホウ素デリバリー2023
- Author(s)
  田畑杏梨、金井大成、河﨑陸、櫻井良憲、真田悠生、立花太郎、中西猛、長﨑健
- Organizer
  BioMedical Forum ２０２３
- Data Source
  KAKENHI-PROJECT-19H04472
[Presentation] 担がんマウスにおけるBSHとHer2に対する二重特異性抗体の腫瘍集積性とBNCT効果2022
- Author(s)
  長﨑　健、田畑杏梨、金井大成、河﨑陸、櫻井良憲、真田悠生、立花太郎、中西猛
- Organizer
  第18回日本中性子捕捉療法学会
- Data Source
  KAKENHI-PROJECT-19H04472
[Presentation] BSHとHer2に対する二重特異性抗体のBNCTホウ素送達ツールとしての評価2022
- Author(s)
  田畑杏梨、金井大成、河﨑陸、櫻井良憲、真田悠生、立花太郎、中西猛、長﨑健
- Organizer
  遺伝子・デリバリー研究会第２１回シンポジウム、第２０回夏期セミナー
- Data Source
  KAKENHI-PROJECT-19H04472
[Presentation] BSHとHer2に対する二重特異性抗体を用いたホウ素デリバリーとBNCT効果2022
- Author(s)
  田畑杏梨、金井大成、河﨑陸、櫻井良憲、真田悠生、立花太郎、中西猛、長﨑健
- Organizer
  第44回日本バイオマテリアル学会
- Data Source
  KAKENHI-PROJECT-19H04472
[Presentation] A combination of GM-CSF and released factors from BNCT and gamma-irradiated tumor cells enhance the differentiation of macrophages from bone marrow cells and their antigen presenting function and polarization to type 12022
- Author(s)
  Ying Tong, Lichao Chen, Shoji Imamichi, Yu Sanada, Satoshi Nakamura, Yuka Sasaki, Tadashige Nozaki, Hiroshi Igaki, Masamichi Ishiai, Minoru Suzuki, Shinichiro Masunaga, Mitsuko Masutani
- Organizer
  第18回日本中性子捕捉療法学会学術大会(つくば、茨城)
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] ホウ素中性子捕捉療法のためのLAT-1 輸送基質を模倣したホウ素キャリアの開発2022
- Author(s)
  永澤秀子、新津明穂、真田悠生、辻美恵子、平山祐、増永慎一郎
- Organizer
  第50回放射線による制癌シンポジウム（札幌）
- Invited
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] 休止期腫瘍細胞特性と腫瘍不均一性並びに癌幹細胞性との相互関連性解析成果に基づく従来型ホウ素送達化合物を用いる中性子捕捉療法の治療効果向上の試み2021
- Author(s)
  増永慎一郎、真田悠生、田野恵三、鈴木実、小野公二
- Organizer
  第49回放射線による制癌シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] Usefulness of combination with both continuous administration of hypoxic cytotoxin, tirapazamine and mild temperature hyperthermia in boron neutron capture therapy in terms of local tumor response and lung metastatic potential.2021
- Author(s)
  Masunaga S, Sakurai Y, Tanaka H, Takata T, Suzuki M, Sanada Y, Tano K, Kondo N, Watanabe T, Takeno S, Maruhashi A, Ono K
- Organizer
  19th International Congress on Neutron Capture Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] Effects Of P53 Status Of Tumor Cells, 10B Delivery Agent Type And Concentration At The Time Of Administration On The Biological Effectiveness For Boron Neutron Capture Therapy.2021
- Author(s)
  Masunaga S, Sanada Y, Tanaka H, Sakurai Y, Tano K, Suzuki M, Ono K
- Organizer
  107th Scientific Assembry and Annual Meeting, Radiological Society of North America
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] BNCT用化合物に特異的な生物学的効果比(CBE)の10B化合物の種類と投与時濃度への依存性2020
- Author(s)
  増永慎一郎、櫻井良憲、田中浩基、高田卓志、真田悠生、田野恵三、鈴木実、近藤夏子、渡邉翼、武野慧、丸橋晃、小野公二
- Organizer
  日本放射線腫瘍学会第33回学術大会（札幌）
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] ホウ素中性子捕捉療法における低酸素細胞毒の連続的投与と低温度温熱療法の同時併用処置の有用性2020
- Author(s)
  増永慎一郎、櫻井良憲、田中浩基、高田卓志、鈴木実、真田悠生、田野恵三、丸橋晃、小野公二
- Organizer
  第79回日本医学放射線学会総会(パシフィコ横浜)
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] 休止期腫瘍細胞特性と癌幹細胞性との関連性解析と癌治療への応用2020
- Author(s)
  増永慎一郎、真田悠生、田野恵三
- Organizer
  第22回菅原・大西記念癌治療増感シンポジウム in 奈良、2020年2月8-9日、奈良
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] Usefulness of Combination with Both Continuous Administration of Hypoxic Cytotoxin, Tirapazamine and Mild Temperature Hyperthermia in Boron Neutron Capture Therapy in Terms of Local Tumor Control and Lung Metastatic Potential.2020
- Author(s)
  Masunaga S, Sakurai Y, Tanaka H, Takata T, Sanada Y, Tano K, Suzuki M, Maruhashi A, Ono K.
- Organizer
  106th Scientific Assembry and Annual Meeting, Radiological Society of North America
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] The Impact of p53 Status on Radio-sensitivity of Quiescent Tumor Cell Population Irradiated with γ-Rays at Various Dose Rates.2019
- Author(s)
  Masunaga S, Kobayashi J, Tano K, Sanada, Y, Sakurai Y, Tanaka H, Takata T, Suzuki M, Maruhashi A, Ono K.
- Organizer
  the 16th International Congress of Radiation Research (ICRR), August. 25- 29, 2019, Manchester, UK.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] Significance of manipulating tumor hypoxia and radiation dose rate in terms of local tumor control and distant lung metastasis.2019
- Author(s)
  Masunaga S, Matsumoto Y, Hirayama R, Tanaka H, Sakurai Y, Suzuki M, Sanada Y, Tano K, Maruhashi A, Ono K.
- Organizer
  the 105th Scientific Assembry and Annual Meeting, Radiological Society of North America, Dec 1-6, 2019, Chicago, IL,USA.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] ホウ素中性子捕捉療法における連続的低酸素細胞毒投与と低温度温熱処置併用の意義 ―局所腫瘍制御と遠隔肺転移からの解析―2019
- Author(s)
  増永　慎一郎、櫻井　良憲、田中　浩基、高田　卓志、鈴木　実、真田　悠、田野　恵三、渡邉　翼、近藤　夏子、玉利　勇樹、武野　慧、丸橋　晃、小野　公二
- Organizer
  第16回日本中性子捕捉療法学会学術大会（宇治、京都大学キャンパス宇治おうばくプラザ）
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] 休止期腫瘍細胞も考慮した局所腫瘍効果と肺転移能に対する腫瘍内酸素状況操作と照射線量率の影響2019
- Author(s)
  増永慎一郎、櫻井良憲、田中浩基、鈴木実、松本孔貴、田野恵三、真田悠生、高田卓志、丸橋晃、小野公二
- Organizer
  第78回日本医学放射線学会総会(パシフィコ横浜)
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] 中性子捕捉療法における連続的低酸素細胞毒投与と低温度温熱処置併用の意義2019
- Author(s)
  増永慎一郎、櫻井良憲、田中浩基、高田卓志、鈴木実、真田悠生、田野恵三、渡邉翼、近藤夏子、武野慧、玉利勇樹、丸橋晃、小野公二
- Organizer
  日本放射線腫瘍学会第32回学術大会（名古屋）
- Data Source
  KAKENHI-PROJECT-19K08171
[Presentation] グルコピラノシルアスコルビン酸の照射後処理による放射線感受性の変化-正常細胞とがん細胞の比較-2018
- Author(s)
  小橋川新子，菓子野元郎，真田悠生，田野恵三，増永慎一郎
- Organizer
  日本放射線影響学会第61回大会(長崎)
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] Effect of the Change in a Reactor Power on the Response of Murine Solid Tumors in Vivo, Referring to that in Intratumor Quiescent Cells and Its Clinical Significance in Boron Neutron Capture Therapy (BNCT).2018
- Author(s)
  Masunaga S, Sakurai Y, Tanaka H, Takata T, Tano K, Sanada Y, Suzuki M, Maruhashi A, Ono K.
- Organizer
  104th Scientific Assembry and Annual Meeting, Radiological Society of North America
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] Disruption of Hif-1alpha enhances the sensitivity to BNCT in murine squamous cell carcinoma.2018
- Author(s)
  Sanada Y, Takata T, Sakurai Y, Tanaka H, Tano K, Masunaga S.
- Organizer
  18th International Congress on Neutron Capture Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] 酸素化休止期腫瘍細胞の照射後回復に対するメトホルミンの効果-チラパザミン、温熱との比較-2018
- Author(s)
  増永慎一郎、田野恵三、真田悠生、櫻井良憲、田中浩基、鈴木　実、近藤夏子、渡邉　翼、高田卓志、小野公二
- Organizer
  第77回日本医学放射線学会総会(パシフィコ横浜)
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] マウス固形腫瘍の挙動に対して原子炉の運転出力変化が及ぼす影響の解析とBoron Neutron Capture Therapy (BNCT)における臨床的意義についての考察2018
- Author(s)
  増永慎一郎、櫻井良憲、田中浩基、高田卓志、田野恵三、真田悠生、鈴木実、近藤夏子、玉利勇樹、丸橋晃、小野公二
- Organizer
  第15回日本中性子捕捉療法学会学術大会（札幌）
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] マウス固形腫瘍の応答に対する原子炉出力変化の影響およびBNCTにおけるその臨床的意義2018
- Author(s)
  増永慎一郎、櫻井良憲、田中浩基、高田卓志、田野恵三、真田悠生、鈴木実、近藤夏子、玉利勇樹、丸橋晃、小野公二
- Organizer
  日本放射線腫瘍学会第31回学術大会（京都）
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] マウス固形腫瘍の挙動に対して原子炉の運転出力変化が及ぼす影響の解析とBoron Neutron Capture Therapy (BNCT)における臨床的意義2018
- Author(s)
  増永慎一郎、櫻井良憲、田中浩基、高田卓志、田野恵三、真田悠生、鈴木実、近藤夏子、玉利勇樹、丸橋晃、小野公二
- Organizer
  第56回日本放射線腫瘍学会生物部会学術大会（東京）
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] 酸素化休止期腫瘍細胞の照射後回復に対するメトホルミンの効果-チラパザミン,温熱との比較-2017
- Author(s)
  増永慎一郎、田野恵三、真田悠生、櫻井良憲、田中浩基、鈴木　実、近藤夏子、渡邉　翼、高田卓志、丸橋晃、小野公二
- Organizer
  日本放射線腫瘍学会第30回学術大会（大阪）
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] 低栄養条件の腫瘍細胞による放射線抵抗性獲得のメカニズム2017
- Author(s)
  真田悠生，田野恵三，増永慎一郎
- Organizer
  日本放射線影響学会第60回大会（千葉）
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] ホウ素中性子捕捉療法における CBE Factor 値の中性子捕捉化合物の種類と投与時における濃度への依存性についての考察2017
- Author(s)
  増永慎一郎、櫻井良憲、田中浩基、田野恵三、真田悠生、鈴木実、近藤夏子、渡邉翼、高田卓志、小野公二
- Organizer
  第14回日本中性子捕捉療法学会学術大会（郡山、福島県）
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] Present status and future plan for physical engineering and medical physics for BNCT in KURRI.2017
- Author(s)
  Yoshinori Sakurai, Hiroki Tanaka, Takushi Takata, Minoru Suzuki, Shinichiro Masunaga, Yuko Kinashi, Natsuko Kondo, Tsubasa Watanabe, Yuki Tamari, Yu Sanada, Koji Ono, Akira Maruhashi.
- Organizer
  9th Young Researchers' BNCT Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] ピモニダゾール非標識休止期腫瘍細胞分画での照射後回復に対するメトフィルミンの効果-ティラパザミンや低温度温熱処置との比較-2017
- Author(s)
  増永慎一郎、田野恵三、真田悠生、鈴木実、小野公二
- Organizer
  日本ハイパーサーミア学会第34回学術大会(京都)
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] Radiosensitivity of Pimonidazole -Unlabeled Intratumor Quiescent Cells to Gamma-Rays, Accelerated Carbon Ion Beams and Boron Neutron Capture Reaction (BNCR).2017
- Author(s)
  Shin-ichiro Masunaga, Yoshinori Sakurai, Hiroki Tanaka, Roichi Hirayama, Yoshitaka Matsumoto, Akiko Uzawa, Keizo Tano, Yu Sanada, Minoru Suzuki, Natsuko Kondo, Takushi Takata, Tsubasa Watanabe, Yuki Tamari, Akira Maruhashi, Koji Ono.
- Organizer
  9th Young Researchers' BNCT Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] 放射線による細胞老化は遅発性活性酸素種が関与する2017
- Author(s)
  小橋川新子，菓子野元郎，真田悠生，田野恵三，増永慎一郎
- Organizer
  日本放射線影響学会第60回大会（千葉）
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] 酸素化休止期腫瘍細胞における放射線照射後回復に対するチラパザミン投与や低温度温熱処置の効果2017
- Author(s)
  増永慎一郎、櫻井良憲、田中浩基、鈴木　実、田野恵三、近藤夏子、真田悠生、渡邉　翼、丸橋　晃、小野公二
- Organizer
  第76回日本医学放射線学会総会
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] 放射線による不可逆的老化様細胞増殖停止への遅発性活性酸素種の関与2017
- Author(s)
  小橋川新子、菓子野元郎、真田悠生、田野恵三、増永慎一郎
- Organizer
  第55回日本放射線腫瘍学会生物部会学術大会（名古屋）
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] The effect of fractionated administration of thalidomide at γ-ray irradiation on tumor response and lung metastasis.2016
- Author(s)
  S. Masunaga, K. Tano, Y. Sanada, Y. Sakurai, H. Tanaka, M. Suzuki, N. Kondo, M. Narabayashi, T. Watanabe, Y. Nakagawa, A. Maruhashi, and K. Ono.
- Organizer
  The International Conference on Translational Research in Radiation Oncology - Physics for Health in Europe 2016
- Place of Presentation
  International Center for Conference in Geneva, Geneva, Switzerland
- Year and Date
  2016-02-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] 腫瘍細胞のメトフォルミン感受性についてHIF-1α欠損が及ぼす効果2016
- Author(s)
  真田悠生，田野恵三，増永慎一郎
- Organizer
  第18回癌治療増感研究シンポジウム、変貌する放射線治療法～物理・化学・生物学増感法のリミックスと免疫学のコラボレーション～
- Place of Presentation
  奈良県文化会館、（奈良県、奈良市）
- Year and Date
  2016-02-05
- Invited
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] Characteristics of the response of intratumor quiescent (Q) cells to irradiation, referring to recruitment from Q to proliferating state.2015
- Author(s)
  Masunaga S, Tano K, Sanada Y, Moriwaki T, Ono K.
- Organizer
  The 15th International Congress of Radiation Research (ICRR)
- Place of Presentation
  国立京都国際会館（京都府、京都市）
- Year and Date
  2015-05-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] 局所腫瘍効果と肺転移抑制能から見たγ線照射時における分割サリドマイド投与併用の意義2015
- Author(s)
  増永慎一郎、真田悠生、森脇隆宏、田野恵三、櫻井良憲、田中浩基、鈴木　実、楢林正流、渡邉　翼、小野公二
- Organizer
  第74回日本医学放射線学会総会
- Place of Presentation
  パシフィコ横浜、（神奈川県、横浜市）
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] マウスモデルを用いたL-FBPA とL-BPA の薬物動態における相同性の検討2015
- Author(s)
  渡邉翼、服部能英、太田洋一郎、石村美紀、切畑光統、仲川洋介、真田悠生、増永慎一郎、平岡真寛、小野公二
- Organizer
  第12回日本中性子捕捉療法学会学術大会
- Place of Presentation
  神戸学院大学、（兵庫県、神戸市）
- Year and Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] Effect of Hif-1α knockout on sensitivity to metformin in SCCVII murine carcinoma cells2015
- Author(s)
  Yu Sanada, Keizo Tano, Shin-ichiro Masunaga
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド、（兵庫県、神戸市）
- Year and Date
  2015-10-01
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] Usefulness of fractionated administrations of thalidomide combined with gamma-ray irradiation in terms of local tumor response and lung metastasis.2015
- Author(s)
  Masunaga S, Sanada Y, Tano K, Sakurai Y, Tanaka H, Suzuki M, Narabayashi M, Watanabe T, Takata T, Maruhashi A, Ono K.
- Organizer
  日本放射線腫瘍学会第28回学術大会
- Place of Presentation
  ベイシア文化ホール、（群馬県、前橋市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15H04295
[Presentation] The effect of oxygen pressure during incubation with a 10B-carrier on 10B uptake capacity of cultured p53 wild-type and mutated tumor cells.2015
- Author(s)
  Masunaga S, Tatebe H, Nishimura Y, Tano K, Sanada Y, Moriwaki T, Sakurai Y, TanakaH, Suzuki M, Maruhashi A,Ono K.
- Organizer
  The 15th International Congress of Radiation Research (ICRR)
- Place of Presentation
  国立京都国際会館（京都府、京都市）
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04295

1. Masunaga Shin-ichiro (80238914)

# of Collaborated Projects: 3 results

# of Collaborated Products: 53 results
2. 田野恵三 (00183468)

# of Collaborated Projects: 3 results

# of Collaborated Products: 43 results
3. 永澤秀子 (90207994)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Nagasaki Takeshi (30237507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 光藤健司 (70303641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 立花太郎 (80311752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. 中西猛 (20422074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. TAKEDA Shun-ichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 中村哲志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 永沢秀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. 平山祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 辻美恵子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 小林純也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 河崎陸

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Sanada Yu 真田 悠生

Research Projects

Research Products

Co-Researchers

Biguanide系薬剤Metforminの腫瘍内環境特性による細胞致死と抗腫瘍免疫誘導の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Interrelationship analysis of the characteristics of quiescent tumor cells with tumor heterogeneity and cancer stem cell nature, referring to application to cancer therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of BNCT Boron Delivery System by Using Bispecific Antibody

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

An attempt to achieve both controlling local tumors and repressing distant metastases through exploiting analytical findings concerning characteristics of intratumor microenvironment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Phospholipid‐Coated Boronic Oxide Nanoparticles as a Boron Agent for Boron Neutron Capture Therapy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Correction: Imamichi et al. Extracellular Release of HMGB1 as an Early Potential Biomarker for the Therapeutic Response in a Xenograft Model of Boron Neutron Capture Therapy. Biology 2022, 11, 4202023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Carborane bearing pullulan nanogel-boron oxide nanoparticle hybrid for boron neutron capture therapy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The impact of TP53 status of tumor cells including the type and the concentration of administered 10B delivery agents on compound biological effectiveness in boron neutron capture therapy.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular Release of HMGB1 as an Early Potential Biomarker for the Therapeutic Response in a Xenograft Model of Boron Neutron Capture Therapy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Solbilization of All-Trans-Retinoic Acid as Macrophage Polarizer by beta-1,3-Glucan2022

Author(s)

Journal Title

Data Source

[Journal Article] Cancer-Targeting Hyaluronic Acid/Carboranyl Pyrene Complex for Boron Neutron Capture Therapy2021

Author(s)

Journal Title

Data Source

[Journal Article] HIF-1α affects sensitivity of murine squamous cell carcinoma to boron neutron capture therapy with BPA.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor-targeting hyaluronic acid/fluorescent carborane complex for boron neutron capture therapy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preparation and Characterization of a Novel Bispecific Antibody That Targets Her2 and BSH for Boron Neutron Capture Therapy2020

Author(s)

Journal Title

Data Source

[Journal Article] An attempt to improve the therapeutic effect of boron neutron capture therapy using commonly employed 10B-carriers based on analytical studies on the correlation among quiescent tumor cell characteristics, tumor heterogeneity and cancer stemness2020

Author(s)

Journal Title

DOI

Data Source

Sanada Yu 真田悠生