Nakatsuka Takuma 中塚拓馬

Researcher Number	50772042
Other IDs	https://orcid.org/0000-0002-5727-5385
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2018 – 2024: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator エピジェネティクス / G9a / ヒストン修飾 / エピゲノム異常 / うっ血肝 / FALD / Fontan / NAFLD / ヒストンメチル化 / 脂肪肝 … More / 非アルコール性脂肪性肝疾患 / ヒストンメチル化修飾 / 肝発がん / アポトーシス / DNA損傷 / 肝癌 … More Except Principal Investigator バイオマーカー / 肝細胞癌 / 薬物療法 / 免疫チェックポイント阻害剤 / ICI関連肝障害 / 自己免疫性肝炎 / 個別化医療 / ゲノム異常 / ゲノム医療 / 血中循環腫瘍DNA / リキッドバイオプシー / 循環腫瘍DNA / cell free DNA / 肝臓がん / 肝がん / 肝癌 Less

自己免疫性肝炎とICI関連肝障害の分子学的差異に基づく病態解明とバイオマーカー開発
- Principal Investigator
  
  中川勇人
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Mie University
肝癌薬物療法における奏功性に関わるケモカインの同定と治療標的としての可能性
- Principal Investigator
  
  山田友春
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Identification of pathogenesis and therapeutic targets in fontan-associated liver disease (FALD)Principal Investigator
- Principal Investigator
  
  中塚拓馬
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Role of histone methylation modifications in the pathogenesis of nonalcoholic fatty liver disease.Principal Investigator
- Principal Investigator
  
  Nakatsuka Takuma
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Personalised treatment of advanced hepatocellular carcinoma using circulating tumor DNA
- Principal Investigator
  
  Tateishi Ryosuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Analysis of epigenetic regulation in the diversity of hepatocellular carcinoma
- Principal Investigator
  
  Minami Tatsuya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Significance of histone methylation in liver carcinogenesis and its possibility as therapeutic targetPrincipal Investigator
- Principal Investigator
  
  Nakatsuka Takuma
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 Other

All Journal Article Presentation Other

[Journal Article] Development and prognosis of hepatocellular carcinoma in patients with diabetes2023
- Author(s)
  Nakatsuka Takuma、Tateishi Ryosuke
- Journal Title
  
  Clinical and Molecular Hepatology
  
  Volume: 29 Issue: 1 Pages: 51-64
- DOI
  10.3350/cmh.2022.0095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08352, KAKENHI-PROJECT-21K15989
[Journal Article] Agile scores are a good predictor of liver-related events in patients with NAFLD2023
- Author(s)
  Nakatsuka Takuma、Tateishi Ryosuke、Sato Masaya、Fujishiro Mitsuhiro、Koike Kazuhiko
- Journal Title
  
  Journal of Hepatology
  
  Volume: - Issue: 3 Pages: e126-e127
- DOI
  10.1016/j.jhep.2023.02.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08352, KAKENHI-PROJECT-21K15989
[Journal Article] Risk stratification of hepatocellular carcinoma after hepatitis C virus eradication in patients with compensated advanced chronic liver disease in Japan2022
- Author(s)
  Nakatsuka Takuma、Tateishi Ryosuke、Nakagomi Ryo、Minami Tatsuya、Koike Kazuhiko
- Journal Title
  
  Journal of Hepatology
  
  Volume: 3 Issue: 2 Pages: 138-138
- DOI
  10.1016/j.jhep.2022.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08352, KAKENHI-PROJECT-21K15989
[Journal Article] Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis2021
- Author(s)
  Takuma Nakatsuka, Keisuke Tateishi*, Hiroyuki Kato, Hiroaki Fujiwara, Keisuke Yamamoto, Yotaro Kudo, Hayato Nakagawa, Yasuo Tanaka, Hideaki Ijichi, Tsuneo Ikenoue, Takeaki Ishizawa, Kiyoshi Hasegawa, Makoto Tachibana, Yoichi Shinkai, Kazuhiko Koike
- Journal Title
  
  Cell Death and Disease
  
  Volume: 12 Issue: 1 Pages: 99111-99111
- DOI
  10.1038/s41419-020-03381-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02419, KAKENHI-PROJECT-18K07961, KAKENHI-PROJECT-19K22388, KAKENHI-PROJECT-18K15741, KAKENHI-ORGANIZER-17H06423, KAKENHI-PLANNED-17H06424
[Journal Article] Post-treatment cell-free DNA as a predictive biomarker in molecular-targeted therapy of hepatocellular carcinoma2021
- Author(s)
  Nakatsuka T、Nakagawa H、Hayata Y、Wake T、Yamada T、Nishibatake Kinoshita M、Nakagmi R、Sato M、Minami T、Uchino K、Enooku K、Kudo Y、Tanaka Y、Kishikawa T、Otsuka M、Tateishi R、Koike K
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: - Issue: 5 Pages: 01773-4
- DOI
  10.1007/s00535-021-01773-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08352, KAKENHI-PROJECT-18H02789, KAKENHI-PROJECT-18K07900, KAKENHI-PROJECT-21K07906
[Journal Article] Radiofrequency Ablation of Liver Tumors in Patients on Antithrombotic Therapy: A Case-Control Analysis of over 10,000 Treatments2021
- Author(s)
  Uchino Koji、Tateishi Ryosuke、Wake Taijiro、Kinoshita Mizuki Nishibatake、Nakagomi Ryo、Nakatsuka Takuma、Minami Tatsuya、Sato Masaya、Enooku Kenichiro、Nakagawa Hayato、Shiina Shuichiro、Koike Kazuhiko
- Journal Title
  
  Journal of Vascular and Interventional Radiology
  
  Volume: - Issue: 6 Pages: 869-877
- DOI
  10.1016/j.jvir.2021.02.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08352
[Journal Article] Changing clinical management of NAFLD in Asia2021
- Author(s)
  Nakatsuka Takuma、Tateishi Ryosuke、Koike Kazuhiko
- Journal Title
  
  Liver International
  
  Volume: 8 Issue: 9 Pages: 15046-15046
- DOI
  10.1111/liv.15046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08352, KAKENHI-PROJECT-21K15989
[Journal Article] Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation2019
- Author(s)
  Fujiwara H、Tateishi K、Misumi K、Hayashi A、Igarashi K、Kato H、Nakatsuka T、Suzuki N、Yamamoto K、Kudo Y、Hayakawa Y、Nakagawa 、Tanaka Y、Ijichi H、Kogure H、Nakai Y、Isayama H、Hasegawa K、Fukayama M、Soga T、Koike K
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 18859-18859
- DOI
  10.1038/s41598-019-55211-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07961, KAKENHI-PROJECT-19K17391, KAKENHI-PROJECT-19K17478, KAKENHI-PROJECT-17K09454, KAKENHI-PROJECT-18K07899, KAKENHI-PROJECT-18K07900
[Presentation] Fontan術後の肝腫瘤発症リスクの検討2023
- Author(s)
  中塚拓馬
- Organizer
  JDDW 2023 (Japan Digestive Disease Week 2023) KOBE
- Data Source
  KAKENHI-PROJECT-23K07411
[Presentation] ラジオ波焼灼術後の腫瘍検体と血漿を用いた肝癌ゲノム解析の可能性2022
- Author(s)
  中塚拓馬、中川勇人、森山慎、福本剛、山田友春、和気泰次郎、佐藤雅哉、南達也、工藤洋太郎、建石良介
- Organizer
  第1回　日本アブレーション研究会
- Data Source
  KAKENHI-PROJECT-20K08352
[Presentation] 肝癌におけるラジオ波焼灼後腫瘍生検の臨床的有用性および遺伝子変異解析の可能性2022
- Author(s)
  中塚拓馬、内野康志、中川勇人、森山慎、福本剛、山田友春、和気泰次郎、佐藤雅哉、南達也、工藤洋太郎、建石良介、藤城光弘
- Organizer
  第58回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-20K08352
[Presentation] Post-treatment cell-free DNA as a predictive biomarker in molecular-targeted therapy of hepatocellular carcinoma2021
- Author(s)
  Takuma Nakatsuka, Hayato Nakagawa, Yuki Hayata, Taijiro Wake, Tomoharu Yamada, Ryo Nakagomi, Masaya Sato, Tatsuya Minami, Koji Uchino, Kenichiro Enooku, Yotaro Kudo, Yasuo Tanaka, Motoyuki Otsuka, Ryosuke Tateishi, Kazuhiko Koike
- Organizer
  JSH International Liver Conference 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08352
[Presentation] Post-treatment cell-free DNA as a predictive biomarker in systemic therapy for HCC2021
- Author(s)
  Takuma Nakatsuka, Hayato Nakagawa, Taijiro Wake, Tomoharu Yamada, Masaya Sato, Tatsuya Minami, Yotaro Kudo, Yasuo Tanaka, Motoyuki Otsuka, Ryosuke Tateishi, Kazuhiko Koike
- Organizer
  APASL Oncology 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08352
[Presentation] Circulating tumor DNA 解析による肝癌層別化治療に向けた試み2020
- Author(s)
  中塚拓馬、中川勇人、小池和彦
- Organizer
  第56回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K08352
[Presentation] 治療後 cell-free DNA 解析による分子標的薬の治療効果予測2020
- Author(s)
  中塚拓馬、中川勇人、早田有希、和気泰次郎、山田友春、木下瑞希、中込良、佐藤雅哉、南達也、榎奥健一郎、工藤洋太郎、田中康雄、大塚基之、建石良介、小池和彦
- Organizer
  第23回日本肝がん分子標的治療研究会
- Data Source
  KAKENHI-PROJECT-20K08352
[Presentation] 治療後cell-free DNA解析による肝癌ゲノム医療に向けた試み2020
- Author(s)
  中塚拓馬、中川勇人、小池和彦
- Organizer
  第28回日本消化器関連学会週間（JDDW 2020）
- Data Source
  KAKENHI-PROJECT-20K08352
[Presentation] ヒストンメチル化酵素G9aは肝細胞のp53依存性DNA損傷応答と発癌に関与する2019
- Author(s)
  中塚拓馬
- Organizer
  第55回肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K15741
[Presentation] Histone methyltransferase G9a promotes hepatocarcinogenesis by regulating p53 transactivity during DNA damage response2018
- Author(s)
  中塚拓馬
- Organizer
  AASLD The Liver Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15741
[]
[]
[]

1. 中川勇人 (00555609)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. 工藤洋太郎 (90608358)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Minami Tatsuya (60459401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Tateishi Ryosuke (50444089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
5. 立石敬介 (20396948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 田中康雄 (40422290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. 藤原直人 (40971693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 浅岡良成 (90431858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 山田友春 (60868024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 藤原弘明 (00814500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 立花誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakatsuka Takuma 中塚 拓馬

Research Projects

Research Products

Co-Researchers

自己免疫性肝炎とICI関連肝障害の分子学的差異に基づく病態解明とバイオマーカー開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肝癌薬物療法における奏功性に関わるケモカインの同定と治療標的としての可能性

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of pathogenesis and therapeutic targets in fontan-associated liver disease (FALD)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of histone methylation modifications in the pathogenesis of nonalcoholic fatty liver disease.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Personalised treatment of advanced hepatocellular carcinoma using circulating tumor DNA

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of epigenetic regulation in the diversity of hepatocellular carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of histone methylation in liver carcinogenesis and its possibility as therapeutic targetPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Development and prognosis of hepatocellular carcinoma in patients with diabetes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Agile scores are a good predictor of liver-related events in patients with NAFLD2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Risk stratification of hepatocellular carcinoma after hepatitis C virus eradication in patients with compensated advanced chronic liver disease in Japan2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Post-treatment cell-free DNA as a predictive biomarker in molecular-targeted therapy of hepatocellular carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Radiofrequency Ablation of Liver Tumors in Patients on Antithrombotic Therapy: A Case-Control Analysis of over 10,000 Treatments2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Changing clinical management of NAFLD in Asia2021

Author(s)

Journal Title

DOI

Nakatsuka Takuma 中塚拓馬