Uehata Takuya 植畑拓也

Researcher Number	50785970
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 京都大学, 医学研究科, 准教授 2019 – 2022: 京都大学, 医学研究科, 助教 2017 – 2019: 京都大学, ウイルス・再生医科学研究所, 助教 2016: 京都大学, ウイルス・再生医科学研究所, 特定助教
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Immunology Except Principal Investigator Transformative Research Areas, Section (II) / Basic Section 56030:Urology-related / Broad Section H
Keywords	Principal Investigator 転写後制御 / mRNA分解 / RNA結合タンパク質 / 炎症制御 / 炎症 / ユビキチン / 自己抗体 / T細胞 / ユビキチン化 / リンパ球初期分化 … More / single cell RNA seq / RNA分解 / lineage bias / lineage priming / 細胞系譜決定 / 造血幹細胞 / 免疫学 / プロテオーム / 免疫細胞 / RBPome / RNA結合タンパク / RNA結合蛋白質 … More Except Principal Investigator 免疫反応 / 弱い相互作用 / 物質共生 / 免疫応答 / 核酸医薬 / Regnase-1 / 免疫療法 / 腎癌 / 抗体産生 / DDS / 人工核酸 / エクソソーム / 毒性 / シンバイオティックス / マテリアル・シンバオシス / シンバイオティクス / シンバイオティックマテリアル / 物理化学 / マテリアル　シンバイオシス / 生体適合性材料 / マテリアル・シンバイオシス / 免疫制御 / サイトカイン / ｍRNA分解 / mRNA制御 / 自然免疫応答 / mRNA修飾 / 免疫細胞分化 / mRNA分解 / 炎症性疾患 Less

新規リボヌクレアーゼRegnase-1を標的とした泌尿器がん新規免疫療法の開発
- Principal Investigator
  
  吉村明洋
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Osaka University
Elucidation of a Novel Mechanism of Regnase-1-mediated mRNA Decay via UbiquitinationPrincipal Investigator
- Principal Investigator
  
  Uehata Takuya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
Biophysical Chemistry for Material Symbiosis
- Principal Investigator
  
  山吉麻子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Nagasaki University
Identification of Symbiotic Communication between Artificial Nucleic Acids and Human Immune Systems
- Principal Investigator
  
  山吉麻子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Nagasaki University
Elucidation of a novel posttranscriptional mechanism regulating early lymphopoiesisPrincipal Investigator
- Principal Investigator
  
  Uehata Takuya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
Analysis of immune regulatory mechanisms mediated by mRNA metabolism
- Principal Investigator
  
  Takeuchi Osamu
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section H
- Research Institution
  Kyoto University
Comprehensive analysis of RNA binding proteins in the immune systemPrincipal Investigator
- Principal Investigator
  
  Uehata Takuya
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book Patent

[Book] 生化学2018
- Author(s)
  植畑　拓也、竹内　理
- Total Pages
  10
- Publisher
  日本生化学会
- Data Source
  KAKENHI-PROJECT-18K15185
[Book] 医学のあゆみ2018
- Author(s)
  植畑　拓也、竹内　理
- Total Pages
  7
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-18K15185
[Journal Article] Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism2022
- Author(s)
  Chong Yee Kien、Tartey Sarang、Yoshikawa Yuki、Imami Koshi、Li Songling、Yoshinaga Masanori、Hirabayashi Ai、Liu Guohao、Vandenbon Alexis、Hia Fabian、Uehata Takuya、Mino Takashi、Suzuki Yutaka、Noda Takeshi、Ferrandon Dominique、Standley Daron M.、Ishihama Yasushi、Takeuchi Osamu
- Journal Title
  
  Science Signaling
  
  Volume: 15 Issue: 729 Pages: 1-19
- DOI
  10.1126/scisignal.abm5011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H04844, KAKENHI-PUBLICLY-21H05720, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-20H03241, KAKENHI-PROJECT-20F20115, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-21K15372, KAKENHI-PROJECT-20K22737
[Journal Article] Enhancement of Regnase-1 expression with stem-loop-targeting antisense oligonucleotides alleviates inflammatory diseases2022
- Author(s)
  Ka Man Tse, Alexis Vandenbon, Xiaotong Cui, Takashi Mino, Takuya Uehata, Keiko Yasuda, Ayuko Sato, Tohru Tsujimura, Fabian Hia, Masanori Yoshinaga, Makoto Kinoshita, Tatsusada Okuno, Osamu Takeuchi
- Journal Title
  
  Science Translational Medicine
  
  Volume: In Press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H05278
[Journal Article] Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages2022
- Author(s)
  Yaku Ai、Inagaki Tadakatsu、Asano Ryotaro、Okazawa Makoto、Mori Hiroyoshi、Sato Ayuko、Hia Fabian、Masaki Takeshi、Manabe Yusuke、Ishibashi Tomohiko、Vandenbon Alexis、Nakatsuka Yoshinari、Akaki Kotaro、Yoshinaga Masanori、Uehata Takuya、Mino Takashi、Morita Satoshi、Ishibashi-Ueda Hatsue、Morinobu Akio et al.
- Journal Title
  
  Circulation
  
  Volume: 146 Issue: 13 Pages: 1006-1022
- DOI
  10.1161/circulationaha.122.059435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15372, KAKENHI-PROJECT-22K16121, KAKENHI-PROJECT-18H05278
[Journal Article] Enhancement of Regnase-1 expression with stem loop?targeting antisense oligonucleotides alleviates inflammatory diseases2022
- Author(s)
  Tse Ka Man、Vandenbon Alexis、Cui Xiaotong、Mino Takashi、Uehata Takuya、Yasuda Keiko、Sato Ayuko、Tsujimura Tohru、Hia Fabian、Yoshinaga Masanori、Kinoshita Makoto、Okuno Tatsusada、Takeuchi Osamu
- Journal Title
  
  Science Translational Medicine
  
  Volume: 14 Issue: 644 Pages: 1-14
- DOI
  10.1126/scitranslmed.abo2137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15372, KAKENHI-PROJECT-18H05278
[Journal Article] Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells2022
- Author(s)
  Ejima Aki、Abe Shinya、Shimba Akihiro、Sato Susumu、Uehata Takuya、Tani-ichi Shizue、Munakata Satoru、Cui Guangwei、Takeuchi Osamu、Hirai Toyohiro、Kato Shigeaki、Ikuta Koichi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 209 Issue: 6 Pages: 1083-1094
- DOI
  10.4049/jimmunol.2200294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-20H03501
[Journal Article] PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases2021
- Author(s)
  Garg Ankur、Roske Yvette、Yamada Shinnosuke、Uehata Takuya、Takeuchi Osamu、Heinemann Udo
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 49 Issue: 9 Pages: 5369-5381
- DOI
  10.1093/nar/gkab316
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-21K07079
[Journal Article] Post-transcriptional regulation of immunological responses by Regnase-1-related RNases2021
- Author(s)
  Uehata Takuya、Takeuchi Osamu
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 12 Pages: 859-865
- DOI
  10.1093/intimm/dxab048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-21K07079
[Journal Article] The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells2020
- Author(s)
  Miyazaki Kazuko、Watanabe Hitomi、Yoshikawa Genki、Chen Kenian、Hidaka Reiko、Aitani Yuki、Osawa Kai、Takeda Rie、Ochi Yotaro、Tani-ichi Shizue、Uehata Takuya、Takeuchi Osamu、Ikuta Koichi、Ogawa Seishi、Kondoh Gen、Lin Yin C.、Ogata Hiroyuki、Miyazaki Masaki
- Journal Title
  
  Science Immunology
  
  Volume: 5 Issue: 51 Pages: 1455-1455
- DOI
  10.1126/sciimmunol.abb1455
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H03487, KAKENHI-PROJECT-19J13775, KAKENHI-PROJECT-18K15185
[Journal Article] RNA Recognition and Immunity?Innate Immune Sensing and Its Posttranscriptional Regulation Mechanisms2020
- Author(s)
  Uehata Takuya、Takeuchi Osamu
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 7 Pages: 1701-1701
- DOI
  10.3390/cells9071701
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-18K15185
[Journal Article] Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by regnase-12020
- Author(s)
  Nakatsuka Yoshinari、Yaku Ai、Handa Tomohiro、Vandenbon Alexis、Hikichi Yuki、Motomura Yasutaka、Sato Ayuko、Yoshinaga Masanori、Tanizawa Kiminobu、Watanabe Kizuku、Hirai Toyohiro、Chin Kazuo、Suzuki Yutaka、Uehata Takuya、Mino Takashi、Tsujimura Tohru、Moro Kazuyo、Takeuchi Osamu
- Journal Title
  
  European Respiratory Journal
  
  Volume: 57 Issue: 3 Pages: 2000018-2000018
- DOI
  10.1183/13993003.00018-2020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-18H05286, KAKENHI-PROJECT-19H03488, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-20K22737, KAKENHI-PROJECT-18K15185
[Journal Article] N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation2019
- Author(s)
  Yamasoba D, Sato K, Ichinose T, Imamura T, Koepke L, Joas S, Reith E, Hotter D, Misawa N, Akaki K, Uehata T, Mino T, Miyamoto S, Noda T, Yamashita A, Standley DM, Kirchhoff F, Sauter D, Koyanagi Y, Takeuchi O.
- Journal Title
  
  Nature Microbiology
  
  Volume: 印刷中
- NAID
  120006731123
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278
[Journal Article] NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements2019
- Author(s)
  Hirabayashi Shigeki、Bhagat Shruti、Matsuki Yu、Takegami Yujiro、Uehata Takuya、Kanemaru Ai、Itoh Masayoshi、Shirakawa Kotaro、Takaori-Kondo Akifumi、Takeuchi Osamu、Carninci Piero、Katayama Shintaro、Hayashizaki Yoshihide、Kere Juha、Kawaji Hideya、Murakawa Yasuhiro
- Journal Title
  
  Nature Genetics
  
  Volume: 51 Issue: 9 Pages: 1369-1379
- DOI
  10.1038/s41588-019-0485-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-18H03992, KAKENHI-PROJECT-16H02902, KAKENHI-PROJECT-18K15185
[Journal Article] N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation.2019
- Author(s)
  Yamasoba D, Sato K, Ichinose T, Imamura T, Koepke L, Joas S, Reith E, Hotter D, Misawa N, Akaki K, Uehata T, Mino T, Miyamoto S, Noda T, Yamashita A, Standley DM, Kirchhoff F, Sauter D, Koyanagi Y, Takeuchi O.
- Journal Title
  
  Nat Microbiol
  
  Volume: 4 Issue: 9 Pages: 1532-1544
- DOI
  10.1038/s41564-019-0460-3
- NAID
  120006731123
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22529, KAKENHI-PROJECT-19K22601, KAKENHI-PROJECT-18KK0447, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-17H04082, KAKENHI-PROJECT-18H02430, KAKENHI-PROJECT-18H02662, KAKENHI-PROJECT-19H03488, KAKENHI-PROJECT-17J10132, KAKENHI-PROJECT-18K15185
[Journal Article] Translation-dependent unwinding of stem?loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs2019
- Author(s)
  Mino Takashi、Iwai Noriki、Endo Masayuki、Inoue Kentaro、Akaki Kotaro、Hia Fabian、Uehata Takuya、Emura Tomoko、Hidaka Kumi、Suzuki Yutaka、Standley Daron M、Okada-Hatakeyama Mariko、Ohno Shigeo、Sugiyama Hiroshi、Yamashita Akio、Takeuchi Osamu
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 47 Pages: 8838-8859
- DOI
  10.1093/nar/gkz628
- NAID
  120006708220
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22601, KAKENHI-PROJECT-18KK0139, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-18H02430, KAKENHI-PROJECT-19H03488, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-16H06356, KAKENHI-PROJECT-18K15185
[Journal Article] Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia2018
- Author(s)
  Nakatsuka Yoshinari、Vandenbon Alexis、Mino Takashi、Yoshinaga Masanori、Uehata Takuya、Cui Xiaotong、Sato Ayuko、Tsujimura Tohru、Suzuki Yutaka、Sato Atsuyasu、Handa Tomohiro、Chin Kazuo、Sawa Teiji、Hirai Toyohiro、Takeuchi Osamu
- Journal Title
  
  Mucosal Immunology
  
  Volume: AOP Issue: 4 Pages: 1203-1218
- DOI
  10.1038/s41385-018-0024-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J08040, KAKENHI-PROJECT-17K08731, KAKENHI-PROJECT-18K15185, KAKENHI-PROJECT-15H05713, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-18H04027, KAKENHI-PROJECT-18H02905, KAKENHI-PROJECT-16K08832, KAKENHI-PROJECT-16H06279
[Journal Article] Regnase-1 Is an Endoribonuclease Essential for the Maintenance of Immune Homeostasis2017
- Author(s)
  Uehata Takuya、Takeuchi Osamu
- Journal Title
  
  Journal of Interferon & Cytokine Research
  
  Volume: 37 Issue: 5 Pages: 220-229
- DOI
  10.1089/jir.2017.0001
- Data Source
  KAKENHI-PROJECT-16H06898
[Journal Article] Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs2017
- Author(s)
  Yoshinaga Masanori、Nakatsuka Yoshinari、Vandenbon Alexis、Ori Daisuke、Uehata Takuya、Tsujimura Tohru、Suzuki Yutaka、Mino Takashi、Takeuchi Osamu
- Journal Title
  
  Cell Reports
  
  Volume: 19 Issue: 8 Pages: 1614-1630
- DOI
  10.1016/j.celrep.2017.05.009
- NAID
  120006305989
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08832, KAKENHI-PROJECT-17K15726, KAKENHI-PROJECT-15H05713, KAKENHI-PROJECT-16H06898, KAKENHI-PROJECT-16J08040, KAKENHI-PROJECT-16H06279
[Journal Article] Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis2017
- Author(s)
  Cui Xiaotong、Mino Takashi、Yoshinaga Masanori、Nakatsuka Yoshinari、Hia Fabian、Yamasoba Daichi、Tsujimura Tohru、Tomonaga Keizo、Suzuki Yutaka、Uehata Takuya、Takeuchi Osamu
- Journal Title
  
  The Journal of Immunology
  
  Volume: 199 Issue: 12 Pages: 4066-4077
- DOI
  10.4049/jimmunol.1701211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08832, KAKENHI-PROJECT-16H06898, KAKENHI-PROJECT-16J08040, KAKENHI-PROJECT-16H06279
[Patent] がんを処置するための組成物2022
- Inventor(s)
  竹内理、植畑拓也
- Industrial Property Rights Holder
  竹内理、植畑拓也
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-088931
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] 非天然型核酸が誘導する免疫惹起機構の解明2023
- Author(s)
  秦萌花、岡本大輝、大山将大、三瓶悠、竹内理、植畑拓也、山吉麻子
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PLANNED-20H05874
[Presentation] Development of a novel anti-tumor nucleic acid therapy targeting RNA structure2022
- Author(s)
  植畑拓也，竹内理
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] The Regnase-1/3-Nfkbiz axis controls hematopoietic lineage priming.2022
- Author(s)
  Uehata T，Ori D，Miyazaki M，Ikawa T，Rodewald H-R，Kawamoto H，Takeuchi O.
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Manipulation of Regnase-1 mRNA stability by antisense oligonucleotides alleviates inflammatory responses in pulmonary and autoimmune diseases2021
- Author(s)
  Ka Man Tse, Xiaotong Cui, Alexis Vandenbon, Keiko Yasuda, Takuya Uehata, Ayuko Sato, Tohru Tsujimura, Masanori Yoshinaga, Tatsusada Okuno, Yoshinari Nakatsuka, Osamu Takeuchi
- Organizer
  KAI International Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Manipulating the expressions of Regnase-1 by stem-loop-targeting-antisense oligonucleotides to counteract inflammatory diseases2021
- Author(s)
  Ka Man Tse, Xiaotong Cui, Alexis Vandenbon, Takashi Mino, Takuya Uehata, Keiko Yasuda, Ayuko Sato, Tohru Tsujimura, Fabian Hia, Masanori Yoshinaga, Osamu Takeuchi
- Organizer
  第44回日本分子生物学年会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Manipulation of Regnase-1 mRNA stability by morpholino-based antisense oligonucleotides alleviates inflammatory responses in pulmonary and autoimmune diseases2021
- Author(s)
  Ka Man Tse, Xiaotong Cui, Alexis Vandenbon, Keiko Yasuda, Takuya Uehata, Ayuko Sato, Tohru Tsujimura, Takashi Mino, Masanori Yoshinaga, Tatsusada Okuno, Yoshinari Nakatsuka, Osamu Takeuchi
- Organizer
  第22回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Regnase-1/-3-Nfkbiz制御軸が造血幹細胞における細胞分化の方向性を調節する2021
- Author(s)
  Takuya Uehata, Daisuke Ori, Masaki Miyazaki, Amir Giladi, Hiroshi Kawamoto, Ido Amit, Osamu Takeuchi
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Regnase-1/-3-Nfkbiz制御軸が造血幹細胞における細胞分化の方向性を調節する2021
- Author(s)
  Takuya Uehata, Daisuke Ori, Masaki Miyazaki, Amir Giladi, Hiroshi Kawamoto, Ido Amit, Osamu Takeuchi
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07079
[Presentation] Lymphoid-myeloid cell fateLymphoid-Myeloid cell fate determination by endoribonucleases Regnase-1 and -32021
- Author(s)
  Takuya Uehata, Shinnosuke Yamada, Masaki Miyazaki, Amir Giladi, Alexis Vandenbon, Ido Amit, Hiroshi Kawamoto, Osamu Takeuchi
- Organizer
  The 27th International Symposium on Molecular Cell Biology of Macrophages
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07079
[Presentation] Post-transcriptional regulation of hematopoietic stem and progenitor cell lineage priming by Rnases Regnase-1/-3 via Nfkbiz mRNA decay2021
- Author(s)
  Takuya Uehata, Daisuke Ori, Masaki Miyazaki, Amir Giladi, Tomokatsu Ikawa, Hiroshi Kawamoto, Ido Amit, Osamu Takeuchi
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07079
[Presentation] Post-transcriptional regulation of hematopoietic stem and progenitor cell lineage priming by Rnases Regnase-1/-3 via Nfkbiz mRNA decay2021
- Author(s)
  Takuya Uehata, Daisuke Ori, Masaki Miyazaki, Amir Giladi, Tomokatsu Ikawa, Hiroshi Kawamoto, Ido Amit, Osamu Takeuchi
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Manipulating the expression of Regnase-1 by antisense oligonucleoties to counteract inflammatory diseases2021
- Author(s)
  Ka Man Tse, Takashi Mino, Takuya Uehata, Keiko Yasuda, Masanori Yoshinaga, Osamu Takeuchi
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Lymphoid-myeloid cell fateLymphoid-Myeloid cell fate determination by endoribonucleases Regnase-1 and -32021
- Author(s)
  Takuya Uehata, Shinnosuke Yamada, Masaki Miyazaki, Amir Giladi, Alexis Vandenbon, Ido Amit, Hiroshi Kawamoto, Osamu Takeuchi
- Organizer
  MMCB2020+1
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] LYMPHOID-MYELOID CELL FATE DETERMINATION BY ENDORIBONUCLEASES REGNASE-1 AND -32020
- Author(s)
  Takuya Uehata, Shinnosuke Yamada, Masaki Miyazaki, Amir Giladi, Alexis Vandenbon, Ido Amit, Hiroshi Kawamoto, and Osamu Takeuchi
- Organizer
  8th Annual Meeting of the International Cytokine & Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15185
[Presentation] Manipulation of Regnase-1 mRNA stability alleviates inflammatory responses in diseased models2020
- Author(s)
  Tse, K.M., Cui, X., Uehata, T., Takeuchi, O.
- Organizer
  RNA2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Manipulation of Regnase-1 mRNA stability alleviates inflammatory responses in diseased models2020
- Author(s)
  Tse, K.M., Cui, X., Uehata, T., Takeuchi, O
- Organizer
  MBSJ2020
- Invited
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Endonucleases Regnase-1 and Regnase-3 regulate transcriptome biases to ensure lymphopoiesis.2019
- Author(s)
  Takuya Uehata, Osamu Takeuchi
- Organizer
  CiRA 2019 International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Critical roles of endonucleases Regnase-1 and Regnase-3 in early lymphopoiesis2019
- Author(s)
  Takuya Uehata
- Organizer
  17th International Congress of Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15185
[Presentation] 免疫細胞を制御するRNA結合タンパク質の機能解析2019
- Author(s)
  植畑拓也
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Critical roles of endonucleases Regnase-1 and Regnase-3 in early lymphopoiesis.2019
- Author(s)
  Takuya Uehata, Osamu Takeuchi
- Organizer
  17th International Congress of Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Ribonucleases Regnase-1 and Regnase-3 have a critical role in cotrolling transcriptome biases in LMPP to ensure lymphopoiesis.2019
- Author(s)
  Shinnosuke Yamada, Takuya Uehata, Osamu Takeuchi
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] 免疫細胞を制御するRNA結合タンパク質の機能解析2019
- Author(s)
  植畑拓也、山田信之輔、織大祐、今見考志、宮崎正輝、石濱泰、河本宏、竹内理
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K15185
[Presentation] Critical Roles of Endonucleases Regnase-1 and Regnase-3 in Early Lymphopoiesis2019
- Author(s)
  Takuya Uehata
- Organizer
  Keystone symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15185
[Presentation] Critical Roles of Endonucleases Regnase-1 and Regnase-3 in Early Lymphopoiesis2019
- Author(s)
  Takuya Uehata
- Organizer
  Keystone symposia, Transcription and RNA Regulation in Inflammation and Immunity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15185
[Presentation] Endonucleases Regnase-1 and Regnase-3 regulate transcriptome biases to ensure lymphopoiesis2019
- Author(s)
  Takuya Uehata, Shinnosuke Yamada, Masaki Miyazaki, Amir Giladi, Alexis Vandenbon, Ido Amit, Hirohi Kawamoto and Osamu Takeuchi
- Organizer
  CiRA 2019 International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15185
[Presentation] Ribonuclease Regnase-1 and Regnase-3 have a critical role in controlling transcriptome biases in LMPP to ensure lymphopoiesis2019
- Author(s)
  Shinnosuke Yamada, Daisuke Ori, Masaki Miyazaki, Takuya Uehata, Osamu Takeuchi
- Organizer
  The 48th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-18K15185
[Presentation] Regnase-1 and Regnase-3 regulate cell fate of early lymphoid progenitors in the bone marrow2018
- Author(s)
  植畑拓也
- Organizer
  第４７回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15185
[Presentation] Critical roles of endonucleases Regnase-1 and Regnase-3 in early lymphopoiesis2018
- Author(s)
  Takuya Uehata, Shinnosuke Yamada, Masaki Miyazaki, Hiroshi Kawamoto, Osamu Takeuchi
- Organizer
  Keystone Symposia, Transcription and RNA Regulation in Inflammation and Immunity (B1)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278

1. 山吉麻子 (70380532)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 山本剛史 (80636994)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Takeuchi Osamu (10379092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 25 results
4. 三野享史 (60646149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. 前仲勝実 (10322752)

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6. 荏原充宏 (10452393)

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7. 望月慎一 (10520702)

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8. 長谷耕二 (20359714)

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9. 大場雄介 (30333503)

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10. 宇都甲一郎 (30597034)

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11. 白石貢一 (40426284)

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12. 森健 (70335785)

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13. 天野麻穂 (80365808)

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14. 吉村明洋 (70981992)

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15. 清谷一馬 (30433642)

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16. 加藤大悟 (70648021)

# of Collaborated Projects: 1 results

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17. Yoshinaga Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 今見考志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 野田岳志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 山下暁朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 榛葉旭恒

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Uehata Takuya 植畑 拓也

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新規リボヌクレアーゼRegnase-1を標的とした泌尿器がん新規免疫療法の開発

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Elucidation of a Novel Mechanism of Regnase-1-mediated mRNA Decay via UbiquitinationPrincipal Investigator

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Biophysical Chemistry for Material Symbiosis

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Identification of Symbiotic Communication between Artificial Nucleic Acids and Human Immune Systems

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Elucidation of a novel posttranscriptional mechanism regulating early lymphopoiesisPrincipal Investigator

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Analysis of immune regulatory mechanisms mediated by mRNA metabolism

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Comprehensive analysis of RNA binding proteins in the immune systemPrincipal Investigator

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[Book] 生化学2018

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[Book] 医学のあゆみ2018

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[Journal Article] Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism2022

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[Journal Article] Enhancement of Regnase-1 expression with stem-loop-targeting antisense oligonucleotides alleviates inflammatory diseases2022

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[Journal Article] Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages2022

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[Journal Article] Enhancement of Regnase-1 expression with stem loop?targeting antisense oligonucleotides alleviates inflammatory diseases2022

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[Journal Article] Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells2022

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Uehata Takuya 植畑拓也