HASE Koji 長谷耕二

Researcher Number	20359714
Other IDs
Affiliation (Current)	2022: 慶應義塾大学, 薬学部(芝共立), 教授
Affiliation (based on the past Project Information) *help	2016 – 2021: 慶應義塾大学, 薬学部(芝共立), 教授 2014 – 2015: 慶應義塾大学, 薬学部, 教授 2013: 東京大学, 医科学研究所, 教授 2012 – 2013: 東京大学, 医科学研究所, 特任教授 2012: 独立行政法人理化学研究所, 免疫器官形成研究グループ, 客員主管研究員 … More
Review Section/Research Field	Principal Investigator Biological Sciences / Immunology / Complex Systems Disease Theory / Medium-sized Section 49:Pathology, infection/immunology, and related fields Except Principal Investigator Biological Sciences / Transformative Research Areas, Section (II) / Food science / Structural biochemistry / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Keywords	Principal Investigator M細胞 / パイエル板 / 粘膜免疫 / 上皮細胞 / 免疫学 / 腸内細菌 / GP2 / FAE / M-Sec / トランスサイトーシス … More Except Principal Investigator 細胞・組織 / 細胞内輸送 / 細胞生物学 / 小胞輸送 / AP複合体 / 極性輸送 / ノックアウトマウス / 輸送シグナル / チロシンモチーフ / 細胞内局在 / 遺伝子欠損マウス / 蛋白質 / SNAP25 / 感染症 / ウイルス / ポリオ / AP-1B / μ1B / 欠損マウス / tGolgin-1 / CLASP / VGAT / ZnT3 / メタボロミクス / 統合オミクス / 腸内細菌 / 腸内代謝産物 / 短鎖脂肪酸 / 酪酸 / 炎症 / 制御性T細胞 / 腸内細菌叢 / メタボロゲノミクス / 腸内エコシステム / メタゲノミクス / メタボローム / エピゲノム / オミクス / 代謝産物 / 免疫修飾因子 / 神経細胞 / 上皮細胞 / 胃酸分泌障害 / てんかんけいれん / GABA / vesicular transport / neurons / epithelial cells / gastric acid secretion / AP complexes / KO mice / sorting signal / 腸管免疫 / 免疫寛容 / ナノ粒子 / 物質共生 / マテリアル・シンバイオシス / 物理化学 / 弱い相互作用 / シンバイオティクス / マテリアル・シンバオシス / シンバイオティックマテリアル / シンバイオティックス / 生活習慣病 / 食餌誘導性肝がん / CREBH / 腸肝連関 Less

Elucidation of the mechanism of liver cancer induced by abnormal lipid metabolism in enterohepatic association
- Principal Investigator
  
  中川嘉
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  University of Toyama
腸内共生系における弱い相互作用の理解と材料共生への応用
- Principal Investigator
  
  森健
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Kyushu University
Biophysical Chemistry for Material Symbiosis
- Principal Investigator
  
  山吉麻子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Nagasaki University
Starvation response of the immune system along the gut-bone marrow axisPrincipal Investigator
- Principal Investigator
  
  長谷耕二
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Keio University
生物間代謝経路によって制御される脂質クオリティの解析Principal Investigator
- Principal Investigator
  
  長谷耕二
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Keio University
Elucidation of pathogenic mechanism of chronic inflammationPrincipal Investigator
- Principal Investigator
  
  Hase Koji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Complex Systems Disease Theory
- Research Institution
  Keio University
Elucidation of T-independent IgA class switch machineryPrincipal Investigator
- Principal Investigator
  
  Hase Koji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Keio University
Single cell analysis of T lymphocytes in the intestinal immune systemPrincipal Investigator
- Principal Investigator
  
  HASE Koji
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Keio University
生物間代謝経路によって制御される脂質クオリティの解析Principal Investigator
- Principal Investigator
  
  長谷耕二
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
腸内代謝バランスに基づく転写制御機構の解明Principal Investigator
- Principal Investigator
  
  長谷耕二
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Host-microbe interaction mediated by intestinal M cellsPrincipal Investigator
- Principal Investigator
  
  Hase Koji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Keio University
  The University of Tokyo
腸管におけるＤＮＡメチル化を介した自然炎症制御機構の解明Principal Investigator
- Principal Investigator
  
  長谷耕二
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
  The Institute of Physical and Chemical Research
Exploring the gut microbiota-derived immunomodulation factors
- Principal Investigator
  
  FUKUDA Shinji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Keio University
粘膜免疫系のシステム構築における上皮細胞とフローラ動態の役割Principal Investigator
- Principal Investigator
  
  長谷耕二
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
The role of membrane nanotubes in the immune systemPrincipal Investigator
- Principal Investigator
  
  HASE Koji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
  The Institute of Physical and Chemical Research
細菌感染におけるM細胞の生理機能と生物学的重要性の解析Principal Investigator
- Principal Investigator
  
  長谷耕二
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
M cell differentiation based on lympho-epithelial interactionPrincipal Investigator
- Principal Investigator
  
  HASE Koji
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research
腸管特殊上皮M細胞における新規病原体取り込み受容体の同定と細胞内輸送機構の解析Principal Investigator
- Principal Investigator
  
  長谷耕二
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
腸管M細胞特異的に発現する遺伝子群の分子機能及び個体レベルにおける高次機能の解析Principal Investigator
- Principal Investigator
  
  長谷耕二
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research
パイエル板特殊上皮M細胞による抗原トランスサイトーシスの分子基盤Principal Investigator
- Principal Investigator
  
  長谷耕二
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
ポリオウイルス感染におけるポリオウイルス受容体サブタイプおよびM細胞の役割の検討
- Principal Investigator
  
  OHNO Hiroshi
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kanazawa University
輸送小胞形成・積み荷蛋白質選別の分子機構とその高次機能における役割
- Principal Investigator
  
  大野博司
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
  Kanazawa University
Analysis of cell-type specific adaptor protein (AP) complexes in cells and organisms
- Principal Investigator
  
  OHNO Hiroshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  RIKEN
  Kanazawa University

[Journal Article] Dietary Intervention Impacts Immune Cell Functions and Dynamics by Inducing Metabolic Rewiring2021
- Author(s)
  Okawa T, Motoyoshi N, and Hase K.,
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 623989-623989
- DOI
  10.3389/fimmu.2020.623989
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00509
[Journal Article] Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation.2021
- Author(s)
  Kurashima Yosuke、Kigoshi Takaaki、Murasaki Sayuri、Arai Fujimi、Shimada Kaoru、Seki Natsumi、Kim Yun-Gi、Hase Koji、Ohno Hiroshi、Kawano Kazuya、Ashida Hiroshi、Suzuki Toshihiko、Morimoto Masako、Saito Yukari、Sasou Ai、Goda Yuki、Yuki Yoshikazu、Inagaki Yutaka、Iijima Hideki、Suda Wataru、Hattori Masahira
- Journal Title
  
  Nat Comm
  
  Volume: 12 Pages: 1067-1067
- DOI
  10.1038/s41467-021-21277-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22627, KAKENHI-PROJECT-20K21530, KAKENHI-PROJECT-20H00509, KAKENHI-PROJECT-17H04159, KAKENHI-PROJECT-17H04166, KAKENHI-PROJECT-19H03450, KAKENHI-PROJECT-19H03467, KAKENHI-PROJECT-20H03490, KAKENHI-PROJECT-19K22634
[Journal Article] Maternal gut microbiota in pregnancy influences offspring metabolic phenotype.2020
- Author(s)
  Kimura I, Miyamoto J, Ohue-Kitano R, Watanabe K, Yamada T, Onuki M, Aoki R, Isobe Y, Kashihara D, Inoue D, Inaba A, Takamura Y, Taira S, Kumaki S, Watanabe M, Ito M, Nakagawa F, Irie J, Kakuta H, Shinohara M, Iwatsuki K, Tsujimoto G, Ohno H, Arita M, Itoh H, Hase K.
- Journal Title
  
  Science
  
  Volume: 367 Pages: 6481-6481
- DOI
  10.1126/science.aaw8429
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08526, KAKENHI-PROJECT-19K22988, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05898, KAKENHI-PUBLICLY-18H04680, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-17H06270, KAKENHI-PROJECT-19J22456, KAKENHI-PROJECT-17KT0055, KAKENHI-PROJECT-18K14414, KAKENHI-PROJECT-18K17920, KAKENHI-PROJECT-20H00535
[Journal Article] Protection of gut microbiome from antibiotics: development of a vancomycin-specific adsorbent with high adsorption capacity2020
- Author(s)
  Yuzuriha K, Hase K, and KATAYAMA Y et al.,
- Journal Title
  
  Bioscience of Microbiota, Food and Health
  
  Volume: 39 Issue: 3 Pages: 128-136
- DOI
  10.12938/bmfh.2020-002
- NAID
  130007881585
- ISSN
  2186-3342
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00509
[Journal Article] Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity2020
- Author(s)
  Kimura S, Nakamura Y, Kobayashi N, Shiroguchi K, KawakamiE, Mutoh M, Takahashi-Iwanaga H, Yamada T, Hisamoto M, Nakamura M, Udagawa N, Sato S, KaishoT, Iwanaga T, Hase K.
- Journal Title
  
  Nat Commun.
  
  Volume: 11 Pages: 1-16
- DOI
  10.1038/s41467-019-13883-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08504, KAKENHI-PROJECT-19K07239, KAKENHI-PROJECT-19K10395, KAKENHI-PROJECT-19K22532, KAKENHI-PROJECT-19K21170, KAKENHI-PUBLICLY-18H04680, KAKENHI-PLANNED-18H05411, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-17KT0055, KAKENHI-PROJECT-17K19776, KAKENHI-PROJECT-20K21689
[Journal Article] Commensal-bacteria-derived butyrate promotes the T-cell-independent IgA response in the colon2020
- Author(s)
  Junya Isobe, Shintarou Maeda, Yuuki Obata, Keito Iizuka, Yutaka Nakamura, Yumiko Fujimura, Tatsuki Kimizuka, Kouya Hattori, Yun-Gi Kim, Tatsuya Morita, Ikuo Kimura, Stefan Offermanns, Takahiro Adachi, Atsuhito Nakao, Hiroshi Kiyono, Daisuke Takahashi, Koji Hase
- Journal Title
  
  Int Immunol.
  
  Volume: 32 Pages: 243-258
- DOI
  10.1093/intimm/dxz078
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15734, KAKENHI-PUBLICLY-18H04680, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-17H05068, KAKENHI-PROJECT-17KT0055
[Journal Article] Microfold Cell-Dependent Antigen Transport Alleviates Infectious Colitis by Inducing Antigen-Specific Cellular Immunity.2020
- Author(s)
  Nakamura Yutaka、Mimuro Hitomi、Kunisawa Jun、Furusawa Yukihiro、Takahashi Daisuke、Fujimura Yumiko、Kaisho Tsuneyasu、Kiyono Hiroshi、Hase Koji
- Journal Title
  
  Mucosal Immunology
  
  Volume: in press Pages: 679-690
- DOI
  10.1038/s41385-020-0263-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04680, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-17KT0055, KAKENHI-PROJECT-19K21170
[Journal Article] Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells2020
- Author(s)
  Daisuke Takahashi, Naomi Hoshina, Yuma Kabumoto, Yuichi Maeda, Akari Suzuki, Hiyori Tanabe, Junya Isobe, Takahiro Yamada, Kisara Muroi, Yuto Yanagisawa, Atsuo Nakamura, ... Koji Hase
- Journal Title
  
  EBioMedicine.
  
  Volume: 58 Pages: 102913-102913
- DOI
  10.1016/j.ebiom.2020.102913
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07552, KAKENHI-PROJECT-20K21515, KAKENHI-PROJECT-20K22788, KAKENHI-PROJECT-20H00509, KAKENHI-PROJECT-18H02636, KAKENHI-PROJECT-17K15734
[Journal Article] Mucin-Derived O-Glycans Act as Endogenous Fiber and Sustain Mucosal Immune Homeostasis via Short-Chain Fatty Acid Production in Rat Cecum2020
- Author(s)
  Hino S, Mizushima T, Kaneko K, Kawai E, Kondo T, Genda T, Yamada T, Hase K, Nishimura N, Morita T
- Journal Title
  
  The Journal of Nutrition
  
  Volume: 150 Pages: 2656-2665
- DOI
  10.1093/jn/nxaa097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22788, KAKENHI-PROJECT-20H00509, KAKENHI-PROJECT-20H02929
[Journal Article] Polyamines polarized Th2/Th9 cell-fate decision by regulating GATA3 expression2020
- Author(s)
  Atsuo Nakamura, Daisuke Takahashi*, Yutaka Nakamura, Takahiro Yamada, Mitsuharu Matsumoto* (*equal correspondence), Koji Hase
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 693 Pages: 108557-108557
- DOI
  10.1016/j.abb.2020.108587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07552, KAKENHI-PROJECT-20H00509, KAKENHI-PROJECT-17K15734
[Journal Article] Regulation of inflammatory response of macrophages and induction of regulatory T cells by using retinoic acid-loaded nanostructured lipid carrier2019
- Author(s)
  Zai Khadijah、Ishihara Narumi、Oguchi Hiroyuki、Hirota Masato、Kishimura Akihiro、Mori Takeshi、Hase Koji、Katayama Yoshiki
- Journal Title
  
  Journal of Biomaterials Science, Polymer Edition
  
  Volume: 30 Pages: 1-11
- DOI
  10.1080/09205063.2018.1493671
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04089, KAKENHI-PUBLICLY-18H04680, KAKENHI-PROJECT-17KT0055
[Journal Article] Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses2019
- Author(s)
  Nagai M、Noguchi R、Takahashi D、Morikawa T、Koshida K、Komiyama S、Ishihara N、Yamada T、Kawamura YI.、Muroi K、Hattori K、Kobayashi N、Fujimura Y、Hirota M、Matsumoto R、Aoki R、Tamura-Nakano M、Sugiyama M、Katakai T、Sato S、Takubo K、Dohi T、Hase K
- Journal Title
  
  Cell
  
  Volume: 178 Pages: 1072-1087
- DOI
  10.1016/j.cell.2019.07.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08379, KAKENHI-PROJECT-19K22528, KAKENHI-PROJECT-19K22532, KAKENHI-PUBLICLY-18H04680, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-17KT0055, KAKENHI-PROJECT-18K19570
[Journal Article] The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases2019
- Author(s)
  Kobayashi Nobuhide、Takahashi Daisuke、Takano Shunsuke、Kimura Shunsuke、Hase Koji
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10 Pages: 2345-2345
- DOI
  10.3389/fimmu.2019.02345
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07239, KAKENHI-PROJECT-17K15734, KAKENHI-PUBLICLY-18H04680, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-17KT0055
[Journal Article] Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis2019
- Author(s)
  Yamada Takahiro、Hino Shingo、Iijima Hideki、Genda Tomomi、Aoki Ryo、Nagata Ryuji、Han Kyu-Ho、Hirota Masato、Kinashi Yusuke、Oguchi Hiroyuki、Suda Wataru、Furusawa Yukihiro、Fujimura Yumiko、Kunisawa Jun、Hattori Masahira、Fukushima Michihiro、Morita Tatsuya、Hase Koji
- Journal Title
  
  EBioMedicine
  
  Volume: 48 Pages: 513-525
- DOI
  10.1016/j.ebiom.2019.09.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04680, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-17KT0055
[Journal Article] Editorial: Immunological Consequences of Antigen Sampling at Mucosal Surfaces2019
- Author(s)
  Mabbott Neil A.、Hase Koji
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10 Pages: 2773-2773
- DOI
  10.3389/fimmu.2019.02773
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04680, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-17KT0055
[Journal Article] Oral Administration of Porphyromonas gingivalis Alters the Gut Microbiome and Serum Metabolome2018
- Author(s)
  Kato Tamotsu、Yamazaki Kyoko、Nakajima Mayuka、Date Yasuhiro、Kikuchi Jun、Hase Koji、Ohno Hiroshi、Yamazaki Kazuhisa
- Journal Title
  
  mSphere
  
  Volume: 3 Pages: 1-11
- DOI
  10.1128/msphere.00460-18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04067, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-18J40011, KAKENHI-PUBLICLY-18H04680, KAKENHI-PROJECT-17KT0055
[Journal Article] Therapeutic effect of vitamin D3-containing nanostructured lipid carriers on inflammatory bowel disease2018
- Author(s)
  Zai Khadijah、Hirota Masato、Yamada Takahiro、Ishihara Narumi、Mori Takeshi、Kishimura Akihiro、Suzuki Koichiro、Hase Koji、Katayama Yoshiki
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 286 Pages: 94-102
- DOI
  10.1016/j.jconrel.2018.07.019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04089, KAKENHI-PUBLICLY-18H04680, KAKENHI-PROJECT-17KT0055
[Journal Article] Intestinal Epithelial Cell-specific Deletion of α-Mannosidase II Ameliorates Experimental Colitis2018
- Author(s)
  Suzuki K., Yamada T, Yamazaki K, Hirota M, Ishihara N, Sakamoto M, Takahashi D, Iijima H, Hase K.
- Journal Title
  
  Cell Structure and Function
  
  Volume: 43 Issue: 1 Pages: 25-39
- DOI
  10.1247/csf.17022
- NAID
  130006513071
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17KT0055, KAKENHI-PROJECT-26293180, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-15J02654, KAKENHI-PROJECT-16K15294, KAKENHI-PROJECT-17H04159, KAKENHI-PUBLICLY-16H01369
[Journal Article] A partial agonist for retinoid X receptor mitigates experimental colitis2018
- Author(s)
  Onuki Masayoshi、Watanabe Masaki、Ishihara Narumi、Suzuki Koichiro、Takizawa Kei、Hirota Masato、Yamada Takahiro、Egawa Aiko、Shibahara Osamu、Nishii Midori、Fujihara Michiko、Makishima Makoto、Takahashi Daisuke、Furusawa Yukihiro、Kakuta Hiroki、Hase Koji
- Journal Title
  
  International Immunology
  
  Volume: 31 Pages: 251-262
- DOI
  10.1093/intimm/dxy089
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04089, KAKENHI-PUBLICLY-18H04680, KAKENHI-PROJECT-17KT0055
[Journal Article] Macrophage extracellular chromatin release induced by Mac-1 mediated platelet-macrophage interactions triggers acute kidney injury in rhabdomyolysis2018
- Author(s)
  Okubo K, Kurosawa M, Kamiya M, Urano Y, Suzuki A, Yamamoto K, Hase K, Homma K, Sasaki J, Miyauchi H, Hoshino T, Hayashi M, Mayadas TN, Hirahashi J.
- Journal Title
  
  Nature medicine
  
  Volume: 24 Pages: 232-238
- DOI
  10.1038/nm.4462
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0055, KAKENHI-PROJECT-16K08634, KAKENHI-PROJECT-16H02606, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-15K09459, KAKENHI-PROJECT-16K15294, KAKENHI-PROJECT-16K19497, KAKENHI-PUBLICLY-16H01369
[Journal Article] IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake.2017
- Author(s)
  Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams I, Kiyono H, and Ohno H.
- Journal Title
  
  J. Exp. Med.
  
  Volume: in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15294
[Journal Article] IL-22BP dictates characteristics of Peyer’s patch follicle-associated epithelium for antigen uptake2017
- Author(s)
  Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams I, Kiyono H, and Ohno H.
- Journal Title
  
  The Journal of Experimental Medicine
  
  Volume: 214 Pages: 1607-1618
- DOI
  10.1084/jem.20160770
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0055, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-17H01559, KAKENHI-PROJECT-16H05207, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-16K14591, KAKENHI-PUBLICLY-16H01369
[Journal Article] Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice.2017
- Author(s)
  Yang JY, Lee YS, Kim Y, Lee SH, Ryu S, Fukuda S, Hase K, Yang CS, Lim HS, Kim MS, Kim HM, Ahn SH, Kwon BE, Ko HJ, Kweon MN.
- Journal Title
  
  Mucosal Immunol.
  
  Volume: 10 Pages: 104-116
- DOI
  10.1038/mi.2016.42
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01369
[Journal Article] NALT M cells are important for immune induction for the common mucosal immune system.2017
- Author(s)
  Date Y, Ebisawa M, Fukuda S, Shima H, Obata Y, Takahashi D, Kato T, Hanazato M, Nakato G, Williams IR, Hase K, Ohno H.
- Journal Title
  
  Int Immunol.
  
  Volume: 29 Pages: 471-478
- DOI
  10.1093/intimm/dxx064
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0055, KAKENHI-PROJECT-16H05207, KAKENHI-PUBLICLY-16H01369
[Journal Article] IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake.2017
- Author(s)
  Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams I, Kiyono H, and Ohno H
- Journal Title
  
  J. Exp. Med.
  
  Volume: in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01369
[Journal Article] Attenuation of CD4 + CD25 + Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug2017
- Author(s)
  Kunisada Y, Eikawa S, Tomonobu N, Domae S, Uehara T, Hori S, Furusawa Y, Hase K, Sasaki A, Udono H.
- Journal Title
  
  EBiomedicine
  
  Volume: 25 Pages: 154-164
- DOI
  10.1016/j.ebiom.2017.10.009
- NAID
  120006767320
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17KT0055, KAKENHI-PROJECT-16K15666, KAKENHI-PUBLICLY-17H05789, KAKENHI-PROJECT-15H04747, KAKENHI-PROJECT-16K18452, KAKENHI-PROJECT-17K19598, KAKENHI-PUBLICLY-16H01369
[Journal Article] Distinct Roles for the N- and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation2016
- Author(s)
  Kimura S, Yamashita M, Yamakami-Kimura M, Sato Y, Yamagata A, Kobashigawa Y, Inagaki F, Amada T, Hase K, Iwanaga T, Ohno H, Fukai S.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Pages: 33548-33548
- DOI
  10.1038/srep33548
- NAID
  120005855947
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01175, KAKENHI-PROJECT-16H04749, KAKENHI-PROJECT-16H04750, KAKENHI-PROJECT-16H05207, KAKENHI-PROJECT-24687012, KAKENHI-PROJECT-16K08457, KAKENHI-PUBLICLY-16H01369
[Journal Article] Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages2016
- Author(s)
  Hashimoto M, Bhuyan F, Hiyoshi M, Noyori O, Nasser H, Miyazaki M, Saito T, Kondoh Y, Osada H, Kimura S, Hase K, Ohno H, Suzu S
- Journal Title
  
  The Journal of immunology
  
  Volume: 196 Pages: 1823-1841
- DOI
  10.4049/jimmunol.1500845
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350976, KAKENHI-PROJECT-26461407, KAKENHI-PUBLICLY-26116709, KAKENHI-PROJECT-15J07744, KAKENHI-PROJECT-25460261
[Journal Article] Zinc transporter SLC39A7/ZIP7 promotes intestinal epithelial self-renewal by resolving ER stress2016
- Author(s)
  Ohashi, W., Kimura, S., Iwanaga, T., Furusawa, Y., Irie, T., Izumi, H., Watanabe, T., Hijikata, A., Hara, T., Ohara, O., Koseki, H., Sato, T., Robine, S., Mori, H., Hattori, Y., Watarai, H., Mishima, K., Ohno, H., Hase, K., Fukada, T.
- Journal Title
  
  PLoS Genet.
  
  Volume: 12
- DOI
  10.1371/journal.pgen.1006349
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01279, KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-26293177, KAKENHI-PROJECT-26462324, KAKENHI-PROJECT-15K15297, KAKENHI-PROJECT-15K19319, KAKENHI-PROJECT-15K08974, KAKENHI-PROJECT-16K11459, KAKENHI-PROJECT-16K08457, KAKENHI-PROJECT-16K15294, KAKENHI-PUBLICLY-16H01369
[Journal Article] The diet-microbiota-metabolite axis regulates the host physiology2016
- Author(s)
  Yamada T, Takahashi D, Hase K.
- Journal Title
  
  Journal of Biochemistry
  
  Volume: in press Pages: 1-10
- DOI
  10.1093/jb/mvw022
- NAID
  40020880708
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26116709, KAKENHI-PROJECT-25293114, KAKENHI-PROJECT-15H06589
[Journal Article] Distinct Roles for the N- and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation.2016
- Author(s)
  Kimura S, Yamashita M, Yamakami-Kimura M, Sato Y, Yamagata A, Kobashigawa Y, Inagaki F, Amada T, Hase K, Iwanaga T, Ohno H, Fukai S.
- Journal Title
  
  Sci. Rep.
  
  Volume: 15 Pages: 33548-33548
- NAID
  120005855947
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15294
[Journal Article] Epithelium-Intrinsic MicroRNAs Contribute to Mucosal Immune Homeostasis by Promoting M-Cell Maturation2016
- Author(s)
  Nakato G, Hase K, Sato T, Kimura S, Sakakibara S, Sugiyama M, Obata Y,Hanazato M, Iwanaga T, Ohno H.
- Journal Title
  
  PLOS ONE
  
  Volume: 11
- DOI
  10.1371/journal.pone.0150379
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-26116709, KAKENHI-PROJECT-15J09641, KAKENHI-PROJECT-25460261, KAKENHI-PROJECT-25293114, KAKENHI-PROJECT-16H05207
[Journal Article] EAF2 mediates germinal center B cell apoptosis to suppress excessive immune responses and prevent autoimmunity2016
- Author(s)
  Li Y, Takahashi Y, Fujii S, Zhou Y, Hong R, Suzuki A, Tsubata T, Hase K, Wang JY.
- Journal Title
  
  Nature Commun.
  
  Volume: 7 Pages: 10836-10836
- DOI
  10.1038/ncomms10836
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26116709, KAKENHI-PROJECT-25293114, KAKENHI-PROJECT-25460604
[Journal Article] AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice2013
- Author(s)
  Koji Hase, Fubito Nakatsu, Masumi Ohmae, Kahushi Sugihara, Noriko Shioda, Daisuke Takahashi, Yuuki Obata, Yukihiro Furusawa, Yumiko Fujimura, Taisuke Yamashita, Shinji Fukuda, Hiroshi Okamoto, Masahide Asano, Shigenobu Yonemura and Hiroshi Ohno.
- Journal Title
  
  Gastroenterology
  
  Volume: 145 Pages: 625-635
- DOI
  10.1053/j.gastro.2013.05.013
- NAID
  40020006198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J02667, KAKENHI-PUBLICLY-24117524, KAKENHI-PUBLICLY-24117723, KAKENHI-PROJECT-25293114
[Journal Article] 統合オミクスが解き明かす腸内細菌叢の機能2013
- Author(s)
  福田真嗣、長谷耕二、大野博司
- Journal Title
  
  実験医学
  
  Volume: 32 Pages: 726-732
- Data Source
  KAKENHI-PROJECT-24380072
[Journal Article] The Epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice2011
- Author(s)
  Takahashi D. and Hase K
- Journal Title
  
  Gastroenterology
  
  Volume: 141巻 Pages: 621-632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689017
[Journal Article] Application of a mouse ligated Peyer's patch intestinal loop assay to evaluate bacterial uptake2011
- Author(s)
  Fukuda S., Hase K., et al
- Journal Title
  
  Journal of Visualized Experiment
  
  Volume: Dec17
- DOI
  10.3791/3225
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22021046, KAKENHI-PROJECT-22689017, KAKENHI-PROJECT-22780132
[Journal Article] CCR6^<hi> CD11c^<int> B cells promote M-cell differentiation in Peyer's patch2011
- Author(s)
  Ebisawa M., Hase K., et al.
- Journal Title
  
  Int.Immunol.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22021046
[Journal Article] CCR6^<hi>CD11c^<int> B cells promote M-cell differentiation in Peyer's patch2011
- Author(s)
  Ebisawa M., Hase K., et al.
- Journal Title
  
  Int.Immunol.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022049
[Journal Article] CCR6^<hi>CD11c^<int> B cells promote M-cell differentiation in Peyer's patch2011
- Author(s)
  Ebisawa M., Hase K., et al.
- Journal Title
  
  Int.Immunol.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689017
[Journal Article] The Epithelia-Specific Membrane Trafficking Factor AP-1B Controls Gut Immune Homeostasis in Mice2011
- Author(s)
  Takahashi, D., et al
- Journal Title
  
  Gastroenterology
  
  Volume: 14 Pages: 621-32
- DOI
  10.1053/j.gastro.2011.04.056
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20113003, KAKENHI-PROJECT-21390055, KAKENHI-PUBLICLY-22021046, KAKENHI-PROJECT-22689017, KAKENHI-PROJECT-23790521
[Journal Article] CCR6hiCD11cint B cells promote M-cell differentiation in Peyer's patch.2011
- Author(s)
  Ebisawa, M., et al
- Journal Title
  
  Int. Immunol.
  
  Volume: 23 Pages: 261-269
- DOI
  10.1093/intimm/dxq478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390155, KAKENHI-PROJECT-21790334, KAKENHI-PROJECT-22689017
[Journal Article] M-Sec, a key molecule for tunneling nanotubule formation.2010
- Author(s)
  Ohno H., Hase K., et al.
- Journal Title
  
  Communicat.Integrat.Biol.
  
  Volume: 3 Pages: 231-233
- Data Source
  KAKENHI-PUBLICLY-22021046
[Journal Article] M-Sec, a key molecule for tunneling nanotubule formation.2010
- Author(s)
  Ohno H., Hase K., et al.
- Journal Title
  
  Communicat.Integrat.Biol.
  
  Volume: 3 Pages: 231-233
- Data Source
  KAKENHI-PUBLICLY-21022049
[Journal Article] M-Sec a key molecule for tunneling nanotubule formation2010
- Author(s)
  Ohno H. and Hase K
- Journal Title
  
  Communicat. Integrat. Biol
  
  Volume: 3巻 Pages: 231-233
- Data Source
  KAKENHI-PROJECT-22689017
[Journal Article] M-Sec, a key molecule for tunneling nanotubule formation.2010
- Author(s)
  Ohno H., Hase K., et al.
- Journal Title
  
  Communicat.Integrat.Biol.
  
  Volume: 3 Pages: 231-233
- Data Source
  KAKENHI-PROJECT-22689017
[Journal Article] Identification of TOSO/FAIM3 as an Fc receptor for IgM2010
- Author(s)
  Shima H, Hase K.et al.
- Journal Title
  
  Int.Immunol. (印刷中)
- NAID
  10027391592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790383
[Journal Article] New approach for M-cell-specific molecules screening by comprehensive transcriptome analysis.2009
- Author(s)
  Nakato G, Fukuda S, Hase K, Goitsuka R, Cooper MD, Ohno H.
- Journal Title
  
  DNA Res. 16
  
  Pages: 227-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790383
[Journal Article] Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.2009
- Author(s)
  Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K, Tobe T, Fujimura Y, Kawano S, Yabashi A, Waguri S, Nakato G, Kimura S, Murakami T, Iimura M, Hamura K, Fukuoka S, Lowe AW, Itoh K, Kiyono H, Ohno H.
- Journal Title
  
  Nature 462
  
  Pages: 226-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790383
[Journal Article] Uptake via Glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response2009
- Author(s)
  Hase K.et al.
- Journal Title
  
  Nature 462
  
  Pages: 226-230
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022049
[Journal Article] New Approach for M-Cell-Specific Molecules Screening by Comprehensive Transcriptome Analysis2009
- Author(s)
  Nakato G, Hase K.et al.
- Journal Title
  
  DNA Res. 16
  
  Pages: 227-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790383
[Journal Article] M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex.2009
- Author(s)
  Hase K, Kimura S, Takatsu H, Ohmae M, Kawano S, Kitamura H, Ito M, Watarai H, Hazelett CC, Yeaman C, Ohno H.
- Journal Title
  
  Nat. Cell Biol. 11
  
  Pages: 1427-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790383
[Journal Article] M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex2009
- Author(s)
  Hase K.et al.
- Journal Title
  
  Nat.Cell Biol. 11
  
  Pages: 1427-1432
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022049
[Journal Article] M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex2009
- Author(s)
  Hase K.et al.
- Journal Title
  
  Nat.Cell Biol. 11
  
  Pages: 1427-1432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790383
[Journal Article] Uptake via Glycoprotein 2 of FimH^+ bacteria by M cells initiates mucosal immune response2009
- Author(s)
  Hase K.et al.
- Journal Title
  
  Nature 462
  
  Pages: 226-230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790383
[Journal Article] IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens.2008
- Author(s)
  Dan SM and Hase K, et al.
- Journal Title
  
  J Immunol 180
  
  Pages: 6816-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041072
[Journal Article] IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens.2008
- Author(s)
  Dann SM, Spehlmann ME, Hammond DC, Iimura M, Hase K, Choi LJ, Hanson E, Eckmann L.
- Journal Title
  
  J. Immunol 180
  
  Pages: 6816-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790383
[Journal Article] Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells2008
- Author(s)
  Terahara K and Hase K, et al.
- Journal Title
  
  J Immunol 180
  
  Pages: 7840-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790383
[Journal Article] A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity.2008
- Author(s)
  Terashima A, Watarai H, Inoue S, Sekine E, Nakagawa R, Hase K, Iwamura C, Nakajima H, Nakayama T, TaniguchiM
- Journal Title
  
  J. Exp. Med. 205
  
  Pages: 2727-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790383
[Journal Article] Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.2008
- Author(s)
  Hase K, Takahashi D, Ebisawa M, Kawano S, Itoh K, Ohno H.
- Journal Title
  
  PLoS ONE 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790383
[Journal Article] A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity.2008
- Author(s)
  Terashima A and Hase K, et al.
- Journal Title
  
  J Exp Med 205
  
  Pages: 2727-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041072
[Journal Article] Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.2008
- Author(s)
  Hase K., et al.
- Journal Title
  
  PLoS ONE 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041072
[Journal Article] Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.2008
- Author(s)
  Hase K, et al.
- Journal Title
  
  PLoS ONE 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790383
[Journal Article] Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells.2008
- Author(s)
  Terahara K, and Hase K, et al.
- Journal Title
  
  J Immunol 180
  
  Pages: 7840-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041072
[Journal Article] IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens2008
- Author(s)
  Dan SM and Hase K, et al.
- Journal Title
  
  J Immunol 180
  
  Pages: 6816-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790383
[Journal Article] A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity2008
- Author(s)
  Terashima A and Hase K, et al.
- Journal Title
  
  J Exp Med 205
  
  Pages: 2727-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790383
[Journal Article] Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells.2008
- Author(s)
  Terahara K, Yoshida M, Igarashi O, Nochi T, Pontes GS, Hase K, Ohno H, Kurokawa S, Mejima M, Takayama N, Yuki Y, Lowe AW, Kiyono H.
- Journal Title
  
  J. Immunol 180
  
  Pages: 7840-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790383
[Journal Article] Splenic CD19-CD35+B220+cells function as an inducer of follicular dendritic cell network formation.2007
- Author(s)
  Murakami T., Chen X., Hase K., et. al.
- Journal Title
  
  Blood 110
  
  Pages: 1215-1224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041072
[Journal Article] Psg18 is specifically expressed in follicle-associated epithelium.2007
- Author(s)
  Kawano K., Ebisawa M. and Hase K., et. al.
- Journal Title
  
  Cell Struct. Funct. 32
  
  Pages: 115-126
- NAID
  40016192024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041072
[Journal Article] Splenic CD19-CD35+B220+ cells function as an inducer of follicular dendritic cell network formation.2007
- Author(s)
  Murakami T., Chen X., Hase K., et. al.
- Journal Title
  
  Blood 110
  
  Pages: 1215-1224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790343
[Journal Article] Psg18 is specifically expressed in follicle-associated epithelium.2007
- Author(s)
  Kawano K., Ebisawa M. and Hase K., et. al.
- Journal Title
  
  Cell Struct. Funct. 32
  
  Pages: 115-126
- NAID
  40016192024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790343
[Journal Article] The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT.2006
- Author(s)
  Hase K., Ohno H.et al.
- Journal Title
  
  J.Immunol. 176(1)
  
  Pages: 43-51
- Data Source
  KAKENHI-PROJECT-17047048
[Journal Article] CD300 antigen like family member G : A novel Ig receptor like protein exclusively expressed on capillary endothelium.2006
- Author(s)
  Takatsu H., Hase K.et al.
- Journal Title
  
  Biochem Biophys Res Commun. 348
  
  Pages: 183-191
- Data Source
  KAKENHI-PROJECT-18790343
[Journal Article] Foxl1-deficient mice exhibit aberrant epithelial cell positioning due to dysregulated EphB/EphrinB expression in the small intestine.2006
- Author(s)
  Takano-Maruyama M, Hase K et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 348
- Data Source
  KAKENHI-PROJECT-18790343
[Journal Article] The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT.2006
- Author(s)
  Hase, K. ほか
- Journal Title
  
  J.Immunol. 176・1
  
  Pages: 43-51
- Data Source
  KAKENHI-PROJECT-15370042
[Journal Article] Foxl1-deficient mice exhibit aberrant epithelial cell positioning due to dysregulated EphB/EphrinB expression in the small intestine.2006
- Author(s)
  Takano-Maruyama M, Hase K, Ohno H. et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol. 291
- Data Source
  KAKENHI-PROJECT-17047048
[Journal Article] CD300 antigen like family member G : A novel lg receptor like protein exclusively expressed on capillary endothelium.2006
- Author(s)
  Takatsu H, Hase K, Uhno H. et al.
- Journal Title
  
  Biochem Biophys Res Uommun. 348
  
  Pages: 183-191
- Data Source
  KAKENHI-PROJECT-17047048
[Journal Article] The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT.2006
- Author(s)
  Hase, K.ほか
- Journal Title
  
  J.Immunol. 176・1
  
  Pages: 43-51
- Data Source
  KAKENHI-PROJECT-15079203
[Journal Article] The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT.2006
- Author(s)
  Hase K.et al.
- Journal Title
  
  J. Immunol. 176 (1)
  
  Pages: 43-51
- Data Source
  KAKENHI-PROJECT-18790343
[Journal Article] Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens.2005
- Author(s)
  Iimura M., Gallo R.L., Hase K.et al.
- Journal Title
  
  J.Immunol. 174(8)
  
  Pages: 4901-4907
- Data Source
  KAKENHI-PROJECT-17047048
[Journal Article] Distinct gene expression profiles characterize cellular phenotypes of follicle- associated epithelium and m cells.2005
- Author(s)
  Hase K., Ohno H.et al.
- Journal Title
  
  DNA Res. 12(2)
  
  Pages: 127-137
- Data Source
  KAKENHI-PROJECT-17047048
[Journal Article] Distinct gene expession profiles characterize cellular phenotypes of follicle-associated epithelium and M cells.2005
- Author(s)
  Hase, K. ほか
- Journal Title
  
  DNA Res. 12・2
  
  Pages: 127-137
- Data Source
  KAKENHI-PROJECT-15370042
[Journal Article] Distinct gene expression profiles characterize cellular phenotypes of follicle-associated epithelium and M cells.2005
- Author(s)
  Hase, K.ほか
- Journal Title
  
  DNA Res. 12・2
  
  Pages: 127-137
- Data Source
  KAKENHI-PROJECT-15079203
[Patent] 腸管M細胞マーカーとしてのGP2の使用2006
- Inventor(s)
  大野博司, 河野和也, 長谷耕二
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2006-12-08
- Data Source
  KAKENHI-PROJECT-17047048
[Presentation] 母体腸内細菌による胎児疾患感受性の制御2021
- Author(s)
  長谷耕二
- Organizer
  第41回日本肥満学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00509
[Presentation] 「免疫と共生」2021
- Author(s)
  長谷耕二
- Organizer
  物質共生領域　キックオフシンポジウム
- Invited
- Data Source
  KAKENHI-ORGANIZER-20H05871
[Presentation] 栄養シグナルによる免疫バリアの制御2020
- Author(s)
  長谷耕二
- Organizer
  東邦大学研究ブランディング事業最終シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17KT0055
[Presentation] 栄養シグナルによる免疫バリアの制御2020
- Author(s)
  長谷耕二
- Organizer
  東邦大学研究ブランディング事業最終シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H04089
[Presentation] 栄養シグナルによる免疫バリアの制御2020
- Author(s)
  長谷耕二
- Organizer
  東邦大学研究ブランディング事業最終シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04680
[Presentation] 母体腸内細菌が産仔の疾患感受性に与える影響2020
- Author(s)
  長谷耕二
- Organizer
  第11回慶應義塾生命科学シンポジウム～食と医科学フォーラム.
- Invited
- Data Source
  KAKENHI-PROJECT-20H00509
[Presentation] Understanding of immune regulation in the gut.2020
- Author(s)
  Koji Hase
- Organizer
  The 49th Annual Meeting of Japanese Society for Immunology.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00509
[Presentation] Nutritional Signals regulate lymphocyte homing to gut-associated lymphoid tissue2020
- Author(s)
  Koji Hase
- Organizer
  The Korean Association of Immunologists (KAI) International Meeting 2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00509
[Presentation] Gut microbiota and diet shape the gut immune system2020
- Author(s)
  Koji Hase
- Organizer
  The 7th Cancer Epigenomics Symposium & Seminar on Hematologic Malignancies and Epigenetics.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00509
[Presentation] 腸内微生物による免疫修飾機構.2020
- Author(s)
  長谷耕二
- Organizer
  第23回日本臨床腸内微生物学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00509
[Presentation] Nutritional Signals regulate lymphocyte homing to gut-associated lymphoid tissue2019
- Author(s)
  Koji Hase
- Organizer
  The 48th Annual Meeting of Japanese Society for Immunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0055
[Presentation] 腸管における免疫監視機構2019
- Author(s)
  長谷耕二
- Organizer
  第22回日本臨床腸内微生物学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17KT0055
[Presentation] 栄養シグナルによるパイエル板リンパ球動態制御2019
- Author(s)
  長谷耕二
- Organizer
  Science Pioneers Consortium (SPC) 2019
- Invited
- Data Source
  KAKENHI-PROJECT-17KT0055
[Presentation] Nutritional Signals regulate lymphocyte homing to gut-associated lymphoid tissue2019
- Author(s)
  Koji Hase
- Organizer
  The 48th Annual Meeting of Japanese Society for Immunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04680
[Presentation] 栄養シグナルによるパイエル板リンパ球動態制御2019
- Author(s)
  長谷耕二
- Organizer
  Science Pioneers Consortium (SPC) 2019
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04680
[Presentation] 腸内細菌を標的とした創薬イノベーション2019
- Author(s)
  長谷耕二
- Organizer
  JASIS2019ライフサイエンスイノベーション
- Invited
- Data Source
  KAKENHI-PROJECT-17H04089
[Presentation] 食物アレルギーの発症に及ぼす腸内代謝物の影響2019
- Author(s)
  長谷耕二
- Organizer
  第68回日本アレルギー学会
- Invited
- Data Source
  KAKENHI-PROJECT-17KT0055
[Presentation] 栄養シグナルによるパイエル板リンパ球動態制御2019
- Author(s)
  長谷耕二
- Organizer
  30th Forum in DOJIN “Nutrio-Metabolomic Pathology”
- Invited
- Data Source
  KAKENHI-PROJECT-17H04089
[Presentation] 栄養シグナルによるパイエル板リンパ球動態制御2019
- Author(s)
  長谷耕二
- Organizer
  日本食品免疫学会設立15周年記念学術集会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04680
[Presentation] 栄養シグナルによるパイエル板リンパ球動態制御2019
- Author(s)
  長谷耕二
- Organizer
  30th Forum in DOJIN “Nutrio-Metabolomic Pathology”
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04680
[Presentation] 栄養シグナルによるパイエル板リンパ球動態制御2019
- Author(s)
  長谷耕二
- Organizer
  日本食品免疫学会設立15周年記念学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17KT0055
[Presentation] 栄養シグナルによるパイエル板リンパ球動態制御2019
- Author(s)
  長谷耕二
- Organizer
  日本食品免疫学会設立15周年記念学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04089
[Presentation] Nutritional signals regulate lymphocyte homing to gut-associated lymphoid tissue2019
- Author(s)
  Koji Hase
- Organizer
  The 7th International Conference on Food Factors (ICoFF2019)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04089
[Presentation] 食物アレルギーの発症に及ぼす腸内代謝物の影響2019
- Author(s)
  長谷耕二
- Organizer
  第68回日本アレルギー学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04089
[Presentation] 腸内細菌を標的とした創薬イノベーション2019
- Author(s)
  長谷耕二
- Organizer
  JASIS2019ライフサイエンスイノベーション
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04680
[Presentation] Nutritional signals regulate lymphocyte homing to gut-associated lymphoid tissue2019
- Author(s)
  Koji Hase
- Organizer
  The 7th International Conference on Food Factors (ICoFF2019)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0055
[Presentation] 食物アレルギーの発症に及ぼす腸内代謝物の影響2019
- Author(s)
  長谷耕二
- Organizer
  第68回日本アレルギー学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04680
[Presentation] 腸内細菌を標的とした創薬イノベーション2019
- Author(s)
  長谷耕二
- Organizer
  JASIS2019ライフサイエンスイノベーション
- Invited
- Data Source
  KAKENHI-PROJECT-17KT0055
[Presentation] Nutritional signals regulate lymphocyte homing to gut-associated lymphoid tissue2019
- Author(s)
  Koji Hase
- Organizer
  The 7th International Conference on Food Factors (ICoFF2019)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04680
[Presentation] 腸管における免疫監視機構2019
- Author(s)
  長谷耕二
- Organizer
  第22回日本臨床腸内微生物学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04089
[Presentation] Nutritional Signals regulate lymphocyte homing to gut-associated lymphoid tissue2019
- Author(s)
  Koji Hase
- Organizer
  The 48th Annual Meeting of Japanese Society for Immunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04089
[Presentation] 栄養シグナルによるパイエル板リンパ球動態制御2019
- Author(s)
  長谷耕二
- Organizer
  Science Pioneers Consortium (SPC) 2019
- Invited
- Data Source
  KAKENHI-PROJECT-17H04089
[Presentation] 腸管における免疫監視機構2019
- Author(s)
  長谷耕二
- Organizer
  第22回日本臨床腸内微生物学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04680
[Presentation] Microbiota-derived metabolites shape mucosal barrier and immunity2017
- Author(s)
  Koji Hase
- Organizer
  Korean Society of Nephrology (KSN) 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04089
[Presentation] Microbiota-derived metabolites shape mucosal barrier & immunity2017
- Author(s)
  Koji Hase
- Organizer
  Korean Society of Nephrology (KSN) 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15294
[Presentation] Microbiota-derived metabolites shape mucosal barrier and immunity2017
- Author(s)
  Koji Hase
- Organizer
  2017 International Congress on Obesity and Metabolic Syndromes (ICOMES)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01369
[Presentation] Microbiota-derived metabolites shape mucosal barrier and immunity2017
- Author(s)
  Koji Hase
- Organizer
  2017 International Congress on Obesity and Metabolic Syndromes (ICOMES)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0055
[Presentation] Microbial metabolites facilitate IgA response in the colon2016
- Author(s)
  Koji Hase, Yuuki Obata, Junya Isobe et al.
- Organizer
  10th European Mucosal Immunology Group Meeting (EMIG2016)
- Place of Presentation
  DGI Byen (Denmark, Copenhagen)
- Year and Date
  2016-10-16
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01369
[Presentation] 腸内細菌定着による免疫エピゲノム修飾変化の誘導2016
- Author(s)
  長谷耕二
- Organizer
  大阪大学蛋白質研究所セミナー「生命システムを支配するエピジェネティクス」
- Place of Presentation
  大阪大学蛋白質研究所(大阪・吹田)
- Year and Date
  2016-12-22
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01369
[Presentation] Microbiota-derived metabolites regulate mucosa immunity and barrier,2016
- Author(s)
  Hase K.
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology.
- Place of Presentation
  Okinawa Convention Center (Okinawa, Ginowan)
- Year and Date
  2016-12-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15294
[Presentation] Microbiota-derived metabolites regulate mucosa immunity and barrier,2016
- Author(s)
  Koji Hase
- Organizer
  The 45th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Okinawa Convention Center (Okinawa, Ginowan)
- Year and Date
  2016-12-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01369
[Presentation] 腸内細菌による免疫エピゲノム修飾機構の解明2015
- Author(s)
  長谷　耕二
- Organizer
  千里ライフサイエンスセミナーJ1「粘膜免疫システムの解明と免疫疾患｣
- Place of Presentation
  千里ライフサイエンスセンター（大阪）
- Year and Date
  2015-05-11
- Invited
- Data Source
  KAKENHI-PUBLICLY-26116709
[Presentation] Symbiotic microorganisms regulate host physiology via interkingdom signaling2015
- Author(s)
  Hase K.
- Organizer
  The 12th Japanese-German Frontiers of Science (JGFoS) Symposium
- Place of Presentation
  Kyoto Brighton Hotel, Kyoto, Japan
- Year and Date
  2015-10-01
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293114
[Presentation] 腸内細菌による代謝物を介した免疫調節メカニズムの解明2015
- Author(s)
  長谷　耕二
- Organizer
  第58回日本放線菌学会学術講演会
- Place of Presentation
  国立感染症研究所（東京）
- Year and Date
  2015-10-30
- Invited
- Data Source
  KAKENHI-PUBLICLY-26116709
[Presentation] Symbiotic microorganisms regulate host physiology via interkingdom signaling2015
- Author(s)
  Hase K.
- Organizer
  The 12th Japanese-German Frontiers of Science (JGFoS) Symposium
- Place of Presentation
  Kyoto Brighton Hotel, Kyoto, Japan
- Year and Date
  2015-10-01
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26116709
[Presentation] Biological significance of intestinal M cells2015
- Author(s)
  Nakamura Y, Hase K et al.
- Organizer
  The 44th Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Sapporo Convention Center, Sapporo, Japan
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-25293114
[Presentation] Intestinal microbiota shapes epithelial barriers & gut immune system.2014
- Author(s)
  Hase K.
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-01
- Invited
- Data Source
  KAKENHI-PUBLICLY-26116709
[Presentation] Commensal bacteria shape the intestinal immune system through epigenetic modifications.2014
- Author(s)
  Hase K. et al.
- Organizer
  International Conference of KSMCB
- Place of Presentation
  Seoul, Korea
- Year and Date
  2014-10-23
- Invited
- Data Source
  KAKENHI-PROJECT-25293114
[Presentation] 酪酸エステル難消化性でんぷんを用いた粘膜免疫系のエピジェネティクス制御.2014
- Author(s)
  長谷耕二
- Organizer
  第68回日本栄養食糧学会
- Place of Presentation
  札幌
- Year and Date
  2014-06-02
- Invited
- Data Source
  KAKENHI-PUBLICLY-26116709
[Presentation] 酪酸エステル難消化性でんぷんを用いた粘膜免疫系のエピジェネティクス制御.2014
- Author(s)
  長谷耕二
- Organizer
  第68回日本栄養食糧学会
- Place of Presentation
  札幌
- Year and Date
  2014-06-02
- Invited
- Data Source
  KAKENHI-PROJECT-25293114
[Presentation] 腸内代謝産物によるエピジェネティクス制御を介したTreg分化誘導2014
- Author(s)
  長谷耕二
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PUBLICLY-24117723
[Presentation] Intestinal microbiota shapes epithelial barriers & gut immune system.2014
- Author(s)
  Hase K.
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-01
- Invited
- Data Source
  KAKENHI-PROJECT-25293114
[Presentation] 腸内細菌由来の代謝産物による免疫バリア修飾作用2014
- Author(s)
  長谷耕二
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PUBLICLY-24117723
[Presentation] 腸内細菌由来の代謝産物による免疫バリア修飾作用2014
- Author(s)
  長谷耕二
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-25293114
[Presentation] Epigenetic machineries facilitate mutualistic immune adaptation to microbial colonization in the gut.2014
- Author(s)
  Koji Hase
- Organizer
  109th Titisee Conference
- Place of Presentation
  Titisee, Germany
- Invited
- Data Source
  KAKENHI-PUBLICLY-24117723
[Presentation] Commensal bacteria shape the intestinal immune system through epigenetic modifications.2014
- Author(s)
  Hase K. et al.
- Organizer
  International Conference of KSMCB
- Place of Presentation
  Seoul, Korea
- Year and Date
  2014-10-23
- Invited
- Data Source
  KAKENHI-PUBLICLY-26116709
[Presentation] 腸内発酵産物による粘膜免疫修飾作用2013
- Author(s)
  長谷耕二
- Organizer
  第67回日本栄養・食糧学会大会
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-25293114
[Presentation] A commensal microbe-derived short-chain fatty acid epigenetically induces colonic regulatory T cells.2013
- Author(s)
  Yukihiro Furusawa, Yuuki Obata and Koji Hase
- Organizer
  The 12th Awaji International Forum on Infection & Immunity.
- Place of Presentation
  Awaji, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-25293114
[Presentation] 上皮特異的膜輸送因子AP-1Bによる腸上皮バリア形成とその破綻による大腸炎発症メカニズム.2013
- Author(s)
  長谷耕二
- Organizer
  日本膜学会第35年会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25293114
[Presentation] Commensal microbiota shapes the gut immune system through epigenetic modifications2013
- Author(s)
  Koji Hase
- Organizer
  The 8th RCAI-JSI International Symposium on Immunology 2013
- Place of Presentation
  Ykohama, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-25293114
[Presentation] Commensal microbiota shapes the gut immune system through epigenetic modifications.2013
- Author(s)
  Koji Hase
- Organizer
  The 8th RCAI-JSI International Symposium on Immunology 2013.
- Place of Presentation
  Yokohama, Japan
- Invited
- Data Source
  KAKENHI-PUBLICLY-24117723
[Presentation] 腸内発酵産物による粘膜免疫系のエピジェネティクス制御2013
- Author(s)
  長谷耕二
- Organizer
  日本食品免疫学会第9回学術大会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PUBLICLY-24117723
[Presentation] A commensal microbe-derived short-chain fatty acid epigenetically induces colonic regulatory T cells.2013
- Author(s)
  Yukihiro Furusawa, Yuuki Obata and Koji Hase
- Organizer
  The 12th Awaji International Forum on Infection & Immunity.
- Place of Presentation
  Awaji, Japan
- Invited
- Data Source
  KAKENHI-PUBLICLY-24117723
[Presentation] 腸内発酵産物による粘膜免疫系のエピジェネティクス制御2013
- Author(s)
  長谷耕二
- Organizer
  日本食品免疫学会第9回学術大会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25293114
[Presentation] 腸内発酵産物による粘膜免疫修飾作用2013
- Author(s)
  長谷耕二
- Organizer
  第67回日本栄養・食糧学会大会
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PUBLICLY-24117723
[Presentation] Epithelial Notch signaling secures lymphoid organogenesis and immune homeostasis in the gut.2012
- Author(s)
  Hase K.
- Organizer
  2012 Annual Meeting of the Japanese Society for Immunology.
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PROJECT-22689017
[Presentation] Intestinal microbiota shapes intestinal T cell balance via epigenetic modifications2012
- Author(s)
  Hase K.
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-22689017
[Presentation] Roles of intestinal M cells in mucosal infection and immunity.2012
- Author(s)
  Hase K.
- Organizer
  第85回日本生化学会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-22689017
[Presentation] Epithelial Notch signaling secures lymphoid organogenesis and immune homeostasis in the gut.2012
- Author(s)
  Hase K.
- Organizer
  2012 Annual Meeting of the Japanese Society for Immunology.
- Place of Presentation
  神戸
- Year and Date
  2012-12-05
- Invited
- Data Source
  KAKENHI-PUBLICLY-24117723
[Presentation] 粘膜表面の感染と宿主応答に果たすＭ細胞の役割2012
- Author(s)
  長谷耕二
- Organizer
  第一回川島腎カンファレンス
- Place of Presentation
  各務原
- Invited
- Data Source
  KAKENHI-PROJECT-22689017
[Presentation] Epithelial immune functions at the interface between self and non-self2011
- Author(s)
  Koji Hase
- Organizer
  2nd CSI/JSI/KAI Joint Symposium on Immunology
- Place of Presentation
  東京(招待講演)
- Data Source
  KAKENHI-PUBLICLY-22021046
[Presentation] 腸管粘膜表面の免疫監視におけるM細胞の重要性の解明2011
- Author(s)
  長谷耕二
- Organizer
  第15回腸内細菌学会
- Place of Presentation
  東京(招待講演)
- Data Source
  KAKENHI-PROJECT-22689017
[Presentation] 感染マトリクス成果報告研究項目(B)細菌2011
- Author(s)
  長谷耕二
- Organizer
  感染現象のマトリックスシンポジウム「感染症研究の未来」
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-22689017
[Presentation] 腸管粘膜表面の免疫監視におけるM細胞の重要性の解明2011
- Author(s)
  長谷耕二
- Organizer
  第15回腸内細菌学会
- Place of Presentation
  東京(招待講演)
- Data Source
  KAKENHI-PUBLICLY-22021046
[Presentation] Epithelial immune functions at the interface between self and non-self2011
- Author(s)
  Koji Hase
- Organizer
  2nd CSI/JSI/KAI Joint Symposium on Immunology
- Place of Presentation
  東京(招待講演)
- Data Source
  KAKENHI-PROJECT-22689017
[Presentation] 感染マトリクス成果報告研究項目(B)細菌2011
- Author(s)
  長谷耕二
- Organizer
  感染現象のマトリックスシンポジウム「感染症研究の未来」
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PUBLICLY-22021046
[Presentation] Specialized epithelial M cells contribute to immunosurveillance on the mucosal surface.2010
- Author(s)
  Hase K.
- Organizer
  The Japanese Society for Immunology 2010 Symposium for "Cutting edge of immunology ; innate immunity and immune regulation"
- Place of Presentation
  東京
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PUBLICLY-21022049
[Presentation] 特殊上皮M細胞による粘膜表面の免疫監視機構2010
- Author(s)
  長谷耕二
- Organizer
  第16回日本ヘリコバクター学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PUBLICLY-22021046
[Presentation] Specialized epithelial M cells contribute to immunosurveillance on the mucosal surface2010
- Author(s)
  Hase K
- Organizer
  The Japanese Society for Immunology 2010 Symposium for Cutting edge of immunology; innate immunity and immuneregulation
- Place of Presentation
  東京
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PROJECT-22689017
[Presentation] M-Sec sec-ures membrane nanotubes with RalA and exocyst2010
- Author(s)
  Hase K.
- Organizer
  International Symposium on Organelle Network : Microbiology, Immunology & Cell Biology
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22689017
[Presentation] Antigen transcytosis by M cells : from molecular entities to biological significance2010
- Author(s)
  Hase K.
- Organizer
  4^<th> Symposium of Immunology Frontier Research Center (IFReC)
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PUBLICLY-22021046
[Presentation] Essential Role of Membrane Trafficking Factor AP-1B in Gut Immune Homeostasis2010
- Author(s)
  Hase K., et al.
- Organizer
  Biochemistry and Molecular Biology 2010
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PUBLICLY-21022049
[Presentation] Antigen transcytosis by M cells : from molecular entities to biological significance2010
- Author(s)
  Hase K.
- Organizer
  4^<th> Symposium of Immunology Frontier Research Center (IFReC)
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PUBLICLY-21022049
[Presentation] Antigen transcytosis by M cells : from molecular entities to biological significance2010
- Author(s)
  Hase K.
- Organizer
  4^<th> Symposium of Immunology Frontier Research Center (IFReC)
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22689017
[Presentation] 特殊上皮M細胞による粘膜表面の免疫監視機構2010
- Author(s)
  長谷耕二
- Organizer
  第16回日本ヘリコバクター学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PUBLICLY-21022049
[Presentation] Essential Role of Membrane Trafficking Factor AP-1B in Gut Immune Homeostasis2010
- Author(s)
  Hase K., et al.
- Organizer
  Biochemistry and Molecular Biology 2010
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22689017
[Presentation] Specialized epithelial M cells contribute to immunosurveillance on the mucosal surface.2010
- Author(s)
  Hase K.
- Organizer
  The Japanese Society for Immunology 2010 Symposium for "Cutting edge of immunology ; innate immunity and immune regulation"
- Place of Presentation
  東京
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PROJECT-22689017
[Presentation] 特殊上皮M細胞による粘膜表面の免疫監視機構2010
- Author(s)
  長谷耕二
- Organizer
  第16回日本ヘリコバクター学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22689017
[Presentation] GP2-dependent antigen transcytosis by M cells initiates mucosal immune response2010
- Author(s)
  長谷耕二
- Organizer
  The 4th Stage Surface Barrier Immunology Study Group(SBARIS). 2^<nd> Meeting
- Place of Presentation
  東京
- Data Source
  KAKENHI-PUBLICLY-21022049
[Presentation] GP2-dependent antigen transcytosis by M cells initiates mucosal immune response. The 4th Stage Surface Barrier Immunology Study Group (SBARIS).2010
- Author(s)
  Hase K
- Organizer
  2nd Meeting
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-20790383
[Presentation] GP2-dependent antigen transcytosis by M cells initiates mucosal immune response2010
- Author(s)
  長谷耕二
- Organizer
  The 4th Stage Surface Barrier Immunology Study Group(SBARIS). 2^<nd> Meeting
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790383
[Presentation] M-Sec sec-ures membrane nanotubes with RalA and exocyst2010
- Author(s)
  Hase K.
- Organizer
  International Symposium on Organelle Network : Microbiology, Immunology & Cell Biology
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PUBLICLY-22021046
[Presentation] M-Sec sec-ures membrane nanotubes with RalA and exocyst2010
- Author(s)
  Hase K.
- Organizer
  International Symposium on Organelle Network : Microbiology, Immunology & Cell Biology
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PUBLICLY-21022049
[Presentation] Specialized epithelial M cells contribute to immunosurveillance on the mucosal surface.2010
- Author(s)
  Hase K.
- Organizer
  The Japanese Society for Immunology 2010 Symposium for "Cutting edge of immunology ; innate immunity and immune regulation"
- Place of Presentation
  東京
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PUBLICLY-22021046
[Presentation] Essential Role of Membrane Trafficking Factor AP-1B in Gut Immune Homeostasis2010
- Author(s)
  Hase K., et al.
- Organizer
  Biochemistry and Molecular Biology 2010
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PUBLICLY-22021046
[Presentation] Uptake via Glycoprotein 2 of FimH^+ bacteria by M cells initiates mucosal immune response2009
- Author(s)
  長谷耕二 et al.
- Organizer
  14^<th> International Congress of Mucosal Immunology
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PUBLICLY-21022049
[Presentation] 粘膜免疫系の最前線におけるM細胞依存的抗原取り込み機構の解明2009
- Author(s)
  長谷耕二
- Organizer
  日本食品免疫学会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-05-27
- Data Source
  KAKENHI-PUBLICLY-21022049
[Presentation] GP2-dependent antigen transcytosis by M cells initiates mucosal immune response.2009
- Author(s)
  Hase K
- Organizer
  第39回日本免疫学会・国際シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20790383
[Presentation] GP2-dependent antigen transcytosis by M cells initiates mucosal immune response2009
- Author(s)
  長谷耕二 et al.
- Organizer
  第39回日本免疫学会・国際シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PUBLICLY-21022049
[Presentation] 粘膜免疫系の最前線におけるM細胞依存的抗原取り込み機構の解明2009
- Author(s)
  長谷耕二
- Organizer
  日本食品免疫学会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-05-27
- Data Source
  KAKENHI-PROJECT-20790383
[Presentation] Uptake via Glycoprotein 2 of FimH^+ bacteria by M cells initiates mucosal immune response2009
- Author(s)
  長谷耕二 et al.
- Organizer
  14^<th> International Congress of Mucosal Immunology
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-20790383
[Presentation] Uptake via Glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response.2009
- Author(s)
  Hase K, Kawano K, Nochi T, Pontes GS, Lowe AW, Kiyono H, Ohno H.
- Organizer
  14th International Congress of Mucosal Immunology (ICMI2009)
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-20790383
[Presentation] GP2-dependent antigen transcytosis by M cells initiates mucosal immune response2009
- Author(s)
  長谷耕二 et al.
- Organizer
  第39回日本免疫学会・国際シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20790383
[Presentation] M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex2009
- Author(s)
  長谷耕二 et al.
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PUBLICLY-21022049
[Presentation] M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex2009
- Author(s)
  長谷耕二 et al.
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20790383
[Presentation] 腸管特殊上皮m細胞による抗原トランスサイトーシスの分子機構2008
- Author(s)
  長谷耕二
- Organizer
  第13回日本食物繊維学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790383
[Presentation] Tunneling nanotubules formed by Peyer's patch M cells : Potential function as the antigen-trapping web.2008
- Author(s)
  Hase K, et al.
- Organizer
  第34回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-19041072
[Presentation] Tunneling nanotubules formed by Peyer's patch M cells: Potential function as the antigen-trapping web2008
- Author(s)
  Hase K, et al.
- Organizer
  第34回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20790383
[Presentation] Function and differentiation of intestinal follicular M cells.2008
- Author(s)
  Hase K
- Organizer
  The 3rd JSI-RCAI Immunology Workshop
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2008-03-14
- Data Source
  KAKENHI-PROJECT-20790383
[Presentation] M-Sec: the M cell-specific Sec family molecule that regulates tunneling nanotubule (TNT) formation2007
- Author(s)
  Hase, K. 他
- Organizer
  第37回日本免疫学会学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-15079203
[Presentation] M-Sec regulates tunneling nanotubule (TNT) formation in intestinal M cells.2007
- Author(s)
  Hase K.
- Organizer
  The 7th Awaji International Forum on Infection and Immunity
- Place of Presentation
  淡路島・兵庫
- Year and Date
  2007-09-04
- Data Source
  KAKENHI-PROJECT-19041072
[Presentation] Activation-induced cytidine deaminase deficiency causes severe gastritis with mucosal hyperplasia2007
- Author(s)
  Hase, K. 他
- Organizer
  13th International Congress of mucosal Immunology
- Place of Presentation
  東京
- Year and Date
  2007-07-11
- Data Source
  KAKENHI-PROJECT-15079203
[Presentation] M-Sec regulates tunneling nanotubule (TNT) formation in intestinal M cells.2007
- Author(s)
  Hase K.
- Organizer
  第37回日本免疫学会・国際シンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-19041072
[Presentation] M-Sec regulates tunneling nanotubule (TNT) formation in intestinal Mcells.2007
- Author(s)
  Hase K.
- Organizer
  The 7th Awaji International Forum on Infection and Immunity
- Place of Presentation
  淡路島・兵庫
- Year and Date
  2007-09-04
- Data Source
  KAKENHI-PROJECT-18790343
[Presentation] M-Sec regulates tunneling nanotubule (TNT) formation in intestinal Mcells.2007
- Author(s)
  Hase K.
- Organizer
  第37回日本免疫学会・国際シンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-18790343
[Presentation] Epithelial immune functions at the interface between self and non-self.
- Author(s)
  Hase K.
- Organizer
  IEIIS2012 Homeostatic Inflammation Satellite Symposium - Infection, Inflammation and Immunity.
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22689017
[Presentation] Commensal bacteria shape gut immune system through epigenetic modifications.
- Author(s)
  Hase K.
- Organizer
  The Fourth International Conference on Regulatory T Cells and Th Subsets and Clinical Application in Human Diseases.
- Place of Presentation
  Shanghai, China
- Year and Date
  2014-11-01 – 2014-11-04
- Invited
- Data Source
  KAKENHI-PROJECT-25293114
[Presentation] Commensal microbiota shapes the gut immune system through epigenetic modifications.
- Author(s)
  Hase K.
- Organizer
  Digestive Disease Week 2014. AGA-JSGE Joint Symposium.
- Place of Presentation
  Chicago, USA
- Year and Date
  2014-05-04 – 2014-05-06
- Invited
- Data Source
  KAKENHI-PROJECT-25293114
[Presentation] 腸内細菌による免疫エピゲノム修飾機構の解明
- Author(s)
  長谷耕二
- Organizer
  第38回阿蘇シンポジウム
- Place of Presentation
  阿蘇
- Year and Date
  2014-07-25 – 2014-07-26
- Invited
- Data Source
  KAKENHI-PUBLICLY-26116709
[Presentation] 腸内細菌による免疫エピゲノム修飾機構の解明
- Author(s)
  長谷耕二
- Organizer
  第38回阿蘇シンポジウム
- Place of Presentation
  阿蘇
- Year and Date
  2014-07-25 – 2014-07-26
- Invited
- Data Source
  KAKENHI-PROJECT-25293114
[Presentation] Epigenetic machineries facilitate mutualistic immune adaptation to microbial colonization in the gut.
- Author(s)
  Hase K.
- Organizer
  109th Titisee Conference
- Place of Presentation
  Titisee, Germanay
- Year and Date
  2014-04-09 – 2014-04-13
- Invited
- Data Source
  KAKENHI-PUBLICLY-26116709
[Presentation] Commensal microbiota shapes the gut immune system through epigenetic modifications.
- Author(s)
  Hase K.
- Organizer
  Digestive Disease Week 2014. AGA-JSGE Joint Symposium.
- Place of Presentation
  Chicago, USA
- Year and Date
  2014-05-04 – 2014-05-06
- Invited
- Data Source
  KAKENHI-PUBLICLY-26116709
[Presentation] Commensal bacteria shape gut immune system through epigenetic modifications.
- Author(s)
  Hase K.
- Organizer
  The Fourth International Conference on Regulatory T Cells and Th Subsets and Clinical Application in Human Diseases.
- Place of Presentation
  Shanghai, China
- Year and Date
  2014-11-01 – 2014-11-04
- Invited
- Data Source
  KAKENHI-PUBLICLY-26116709
[Presentation] Epigenetic machineries facilitate mutualistic immune adaptation to microbial colonization in the gut.
- Author(s)
  Hase K.
- Organizer
  109th Titisee Conference
- Place of Presentation
  Titisee, Germanay
- Year and Date
  2014-04-09 – 2014-04-13
- Invited
- Data Source
  KAKENHI-PROJECT-25293114

1. OHNO Hiroshi (50233226)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
2. FUKUDA Shinji (80435677)

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# of Collaborated Products: 3 results
3. 森健 (70335785)

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# of Collaborated Projects: 1 results

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7. MURAKAMI Takaya (10399446)

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33. NAKAMURA Hiroshi

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34. SATO Shintaro

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35. IIJIMA Hideki

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36. MORITA Tatsuya

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42. KUROSAWA Miho

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43. URANO Yasuteru

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# of Collaborated Products: 1 results
63. 宇田川信之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
64. 中村有孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
65. 改正恒康

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
66. 金倫基

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
67. 小松紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
68. 山崎慶子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
69. 鈴木康夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
70. 日野真吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
71. 倉島洋介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
72. 鈴木敏彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
73. 榮川伸吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
74. 堀昌平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
75. 王継揚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
76. 神谷真子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
77. 平橋淳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
78. 北村浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HASE Koji 長谷 耕二

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of liver cancer induced by abnormal lipid metabolism in enterohepatic association

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腸内共生系における弱い相互作用の理解と材料共生への応用

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Biophysical Chemistry for Material Symbiosis

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Starvation response of the immune system along the gut-bone marrow axisPrincipal Investigator

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生物間代謝経路によって制御される脂質クオリティの解析Principal Investigator

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Elucidation of pathogenic mechanism of chronic inflammationPrincipal Investigator

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Elucidation of T-independent IgA class switch machineryPrincipal Investigator

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Single cell analysis of T lymphocytes in the intestinal immune systemPrincipal Investigator

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生物間代謝経路によって制御される脂質クオリティの解析Principal Investigator

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腸内代謝バランスに基づく転写制御機構の解明Principal Investigator

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Host-microbe interaction mediated by intestinal M cellsPrincipal Investigator

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腸管におけるＤＮＡメチル化を介した自然炎症制御機構の解明Principal Investigator

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Exploring the gut microbiota-derived immunomodulation factors

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HASE Koji 長谷耕二