Miyauchi Yuu 宮内優

Researcher Number	50799947
Other IDs
Affiliation (Current)	2025: 崇城大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 崇城大学, 薬学部, 講師 2021: 九州大学, 薬学研究院, 助教 2018 – 2019: 九州大学, 薬学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Environmental impact assessment
Keywords	Principal Investigator シトクロムP450 / 薬物代謝酵素 / エピソーマルベクター / 糖化産物 / 活性酸素種 / タンパク質間相互作用 / UDP-グルクロン酸転移酵素 / 終末糖化産物 / エレクトロポレーション / 肝疾患 … More / 酵素誘導 / 肝臓 / 肝障害 / 細胞ストレス / 活性酸素 / 小胞体 / bac-mam system / シトクロムP450 3A4 / 終末糖化産物受容体 / 酸化ストレス / 哺乳動物細胞 / バキュロウイルス … More Except Principal Investigator 薬学 / 環境 / 有害化学物質 / 環境汚染物質 / 環境化学物質 / 発育障害 / プロラクチン / 成長ホルモン / 黄体形成ホルモン / 次世代影響 / ダイオキシン Less

Flexible mechanism of variation of drug-metabolizing ability focusing on enzyme complexesPrincipal Investigator
- Principal Investigator
  
  宮内優
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Sojo University
Cytochrome P450-mediated liver toxicity possibly via increasing sensitivity toward glycation productsPrincipal Investigator
- Principal Investigator
  
  Miyauchi Yuu
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Sojo University
Suppression of oxidative stress by protein-protein interaction between cytochrome P450 and UDP-glucuronosyltransferasePrincipal Investigator
- Principal Investigator
  
  Miyauchi Yuu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Sojo University
Assessment of the impact of the disturbance in endo-and-xeno environment on the next-generation: study on the mechanism for sexual immaturity and developmental disorders and the preventive method
- Principal Investigator
  
  Ishii Yuji
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Environmental impact assessment
- Research Institution
  Kyushu University

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products2023
- Author(s)
  Miyauchi Yuu、Koba Haruna、Sawai Madoka、Kansui Hisao、Takechi Shinji
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 48 Issue: 5 Pages: 263-272
- DOI
  10.2131/jts.48.263
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15330
[Journal Article] Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A42022
- Author(s)
  Miyauchi Yuu、Kimura Akane、Sawai Madoka、Fujimoto Keiko、Hirota Yuko、Tanaka Yoshitaka、Takechi Shinji、Mackenzie Peter I.、Ishii Yuji
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 13
- DOI
  10.3389/fphar.2022.832931
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16045, KAKENHI-PROJECT-20K07199
[Journal Article] Protein-Protein Interactions as Underlying Regulatory Mechanisms of Drug-metabolizing Enzyme Function2022
- Author(s)
  Miyauchi Yuu
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 142 Issue: 11 Pages: 1169-1175
- DOI
  10.1248/yakushi.22-00124
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2022-11-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15330, KAKENHI-PROJECT-20K16045
[Journal Article] Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Individual Differences2021
- Author(s)
  Miyauchi Yuu、Takechi Shinji、Ishii Yuji
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 11 Pages: 1635-1644
- DOI
  10.1248/bpb.b21-00286
- NAID
  130008110311
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-11-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16045
[Journal Article] Molecular mechanism of dihydropyrazine-induced cytotoxicity: the possibility of an independent pathway from the receptor for advanced glycation end products2021
- Author(s)
  Miyauchi Yuu、Sawai Madoka、Ishida Takumi、Kansui Hisao、Takechi Shinji
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 11 Pages: 509-514
- DOI
  10.2131/jts.46.509
- NAID
  130008110423
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] UDP-グルクロン酸転移酵素のオリゴマー検出とその形成部位の予測2023
- Author(s)
  宮内優，澤井円香，武知進士，Makenzie Peter，石井祐次
- Organizer
  フォーラム2023衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-22K15330
[Presentation] ジヒドロピラジンによる酸化ストレスの惹起と細胞障害：主要メイラード反応産物との比較2023
- Author(s)
  宮内　優，澤井円香，寒水壽朗，武知進士
- Organizer
  第50回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-22K15330
[Presentation] Detection of UDP-glucuronosyltransferase in several oligomeric forms by immunoblotting and prediction of oligomer-forming sites with deletion mutants2023
- Author(s)
  Miyauchi Y., Sawai M., Takechi S., Mackenzie P.I., and Ishii Y.
- Organizer
  2023 International Joint Meeting of the 23rd ICCP450 and the 38th JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15330
[Presentation] ジヒドロピラジンによる細胞障害機構の解明：糖化産物間における酸化ストレス誘導性の比較2023
- Author(s)
  宮内　優, 澤井円香, 寒水壽朗, 武知進士
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K15330
[Presentation] UDP-グルクロン酸転移酵素のオリゴマー解析2023
- Author(s)
  宮内　優
- Organizer
  内外環境応答・代謝酵素研究会
- Data Source
  KAKENHI-PROJECT-22K15330
[Presentation] 糖化産物ジヒドロピラジンと他のメイラード反応産物の細胞毒性の比較2023
- Author(s)
  磯田昌秀，宮内　優，澤井円香，寒水壽朗，武知進士
- Organizer
  第40回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-22K15330
[Presentation] Investigation of the function of UDP-glucuronosyltransferase focusing on its enzymatic features: C-terminal cytoplasmic peptide and oligomer formation2023
- Author(s)
  Miyauchi Y.
- Organizer
  2023 International Joint Meeting of the 23rd ICCP450 and the 38th JSSX
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15330
[Presentation] ジヒドロピラジンによる細胞障害機構の解明：糖化産物間における酸化ストレス誘導性の比較2023
- Author(s)
  宮内　優, 澤井円香, 寒水壽朗, 武知進士
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] 細胞内におけるUDP-グルクロン酸転移酵素の高次オリゴマーとしての検出2023
- Author(s)
  宮内　優，澤井円香，寒水壽朗，武知進士，Mackenzie Peter，石井祐次
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15330
[Presentation] 糖化産物ジヒドロピラジンによる細胞障害の機構解明：抗酸化物質を用いた毒性軽減作用の検討2022
- Author(s)
  宮内　優, 澤井円香, 寒水壽朗, 武知進士
- Organizer
  フォーラム2022衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-22K15330
[Presentation] UDP-グルクロン酸抱合酵素との相互作用によるシトクロムP450機能の抑制2022
- Author(s)
  宮内　優
- Organizer
  内外環境応答・代謝酵素研究会
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] シトクロムP450とUDP-グルクロン酸転移酵素のタンパク質間相互作用と機能変動：ドキシサイクリン誘導発現系の構築2022
- Author(s)
  宮内　優, 石井祐次, 武知進士
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] UDP-グルクロン酸抱合酵素との相互作用によるシトクロムP450機能の抑制2022
- Author(s)
  宮内　優
- Organizer
  内外環境応答・代謝酵素研究会
- Data Source
  KAKENHI-PROJECT-22K15330
[Presentation] Application of antioxidants in dihydropyrazine-induced oxidative stress2022
- Author(s)
  Miyauchi Y., Sawai M., Kansui H., and Takechi S.
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] シトクロムP450とUDP-グルクロン酸転移酵素のタンパク質間相互作用と機能変動：ドキシサイクリン誘導発現系の構築2022
- Author(s)
  宮内　優, 石井祐次, 武知進士
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-22K15330
[Presentation] Functional interactions between different drug-metabolizing enzymes: a novel approach for variance in CYP3A4 activity2022
- Author(s)
  Miyauchi Y.
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-22K15330
[Presentation] Application of antioxidants in dihydropyrazine-induced oxidative stress2022
- Author(s)
  Miyauchi Y., Sawai M., Kansui H., and Takechi S.
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-22K15330
[Presentation] Functional interactions between different drug-metabolizing enzymes: a novel approach for variance in CYP3A4 activity2022
- Author(s)
  Miyauchi Y.
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] 糖化産物ジヒドロピラジンによる細胞障害の機構解明：抗酸化物質を用いた毒性軽減作用の検討2022
- Author(s)
  宮内優, 澤井円香, 寒水壽朗, 武知進士
- Organizer
  フォーラム2022衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] 糖化産物ジヒドロピラジン類による細胞毒性の機構解明：終末糖化産物との相違点2022
- Author(s)
  宮内優, 澤井円香, 石田卓巳, 寒水壽朗, 武知進士
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] タンパク質間相互作用による薬物代謝酵素の制御機構2021
- Author(s)
  宮内　優
- Organizer
  第38回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] 新規シトクロムP450 3A4 発現系の構築：バキュロウイルスを用いたCOS-1細胞における過剰発現2021
- Author(s)
  宮内優, 木村茜, 江﨑円香, 藤本景子, 廣田有子, 武知進士, 石井祐次, 田中嘉孝
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] UDP-グルクロン酸転移酵素研究の基盤：小胞体局在機構、機能発現、およびシトクロムP450機能調節2021
- Author(s)
  宮内　優
- Organizer
  フォーラム2021衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] ジヒドロピラジンによる細胞毒性に終末糖化産物受容体が及ぼす影響2021
- Author(s)
  宮内　優, 澤井円香, 石田卓巳, 寒水壽朗, 武知進士
- Organizer
  フォーラム2021衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] Heterologous expression of UDP-glucuronosyltransferase in COS-1 cells with an episomal vector2021
- Author(s)
  Miyauchi Y., Mackenzie P.I., Ishii Y., and Takechi S.
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] 糖化産物中間体ジヒドロピラジン類の細胞毒性機構解明：終末糖化産物関連受容体の関与2021
- Author(s)
  宮内優, 澤井円香, 石田卓巳, 寒水壽朗, 武知進士
- Organizer
  第38回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] ジヒドロピラジンによる細胞毒性の分子機構解明：終末糖化産物受容体の寄与2021
- Author(s)
  宮内　優, 澤井円香, 石田卓巳, 寒水壽朗, 武知進士
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] Efficient expressions of cytochrome P450 3A4 in mammalian cells with a Bac-Mam system2020
- Author(s)
  Miyauchi Y., Kimura A., Esaki M., Fujimoto K., Hirota Y., Takechi S., Ishii Y., and Tanaka Y.
- Organizer
  日本薬物動態学会第35回年会
- Data Source
  KAKENHI-PROJECT-20K16045
[Presentation] 新たな薬物代謝酵素発現系の構築：遺伝子改変バキュロウイルスを用いた哺乳動物細胞への遺伝子導入2020
- Author(s)
  宮内優, 木村茜, 江﨑円香, 藤本景子, 廣田有子, 武知進士, Mackenzie Peter, 石井祐次, 田中嘉孝
- Organizer
  フォーラム2020 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-20K16045

1. Ishii Yuji (90253468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 廣田有子 (50588259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Miyauchi Yuu 宮内 優

Research Projects

Research Products

Co-Researchers

Flexible mechanism of variation of drug-metabolizing ability focusing on enzyme complexesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cytochrome P450-mediated liver toxicity possibly via increasing sensitivity toward glycation productsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Suppression of oxidative stress by protein-protein interaction between cytochrome P450 and UDP-glucuronosyltransferasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Assessment of the impact of the disturbance in endo-and-xeno environment on the next-generation: study on the mechanism for sexual immaturity and developmental disorders and the preventive method

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A42022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protein-Protein Interactions as Underlying Regulatory Mechanisms of Drug-metabolizing Enzyme Function2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Individual Differences2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Molecular mechanism of dihydropyrazine-induced cytotoxicity: the possibility of an independent pathway from the receptor for advanced glycation end products2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Presentation] UDP-グルクロン酸転移酵素のオリゴマー検出とその形成部位の予測2023

Author(s)

Organizer

Data Source

[Presentation] ジヒドロピラジンによる酸化ストレスの惹起と細胞障害：主要メイラード反応産物との比較2023

Author(s)

Organizer

Data Source

[Presentation] Detection of UDP-glucuronosyltransferase in several oligomeric forms by immunoblotting and prediction of oligomer-forming sites with deletion mutants2023

Author(s)

Organizer

Data Source

[Presentation] ジヒドロピラジンによる細胞障害機構の解明：糖化産物間における酸化ストレス誘導性の比較2023

Author(s)

Organizer

Miyauchi Yuu 宮内優

[Presentation] シトクロムP450とUDP-グルクロン酸転移酵素のタンパク質間相互作用と機能変動：ドキシサイクリン誘導発現系の構築2022

[Presentation] シトクロムP450とUDP-グルクロン酸転移酵素のタンパク質間相互作用と機能変動：ドキシサイクリン誘導発現系の構築2022