OKAMOTO Hiroshi 岡本宏

… Alternative Names

岡本宏オカモトヒロシ

Less

Researcher Number	60025632
Other IDs
External Links
Affiliation (Current)	2025: 東北大学, その他部局等, その他
Affiliation (based on the past Project Information) *help	2004 – 2005: 東北大学, 大学院・医学系研究科, 教授 2003 – 2004: 東北大学, 大学院・医学系研究科, 客員教授 2002: 東北大学, 大学院・医学系研究科, 教授 2001 – 2002: 東北大学, 医学系研究科, 教授 1999 – 2000: 東北大学, 大学院・医学系研究科, 教授 … More 1991 – 1998: 東北大学, 医学部, 教授 1986 – 1989: 東北大学, 医学部, 教授 1986: 東北大, 医学部, 教授 1986: Tohoku University School of Medicine, 医学部医化学第一講座, 教授 1985: 東北大学, 医, 教授 Less
Review Section/Research Field	Principal Investigator General medical chemistry / Biological Sciences / Pathological medical chemistry Except Principal Investigator Biological Sciences / 内分泌・代謝学 / General medical chemistry / General medical chemistry / Digestive surgery / Functional biochemistry / Biological pharmacy
Keywords	Principal Investigator cyclic ADP-ribose hydrolase / ADP-ribosyl cyclase / CD38 / cyclic ADP-ribose / insulin secretion / second messenger / Vasoactive Intestinal Peptide / 遺伝子クローニング / インスリン分泌 / 部位特異的変異法 … More / 細胞内情報伝達物質 / pancreatic islet β-cells / Pancreatic beta-Cells of the Islets of Langerhans / reg (Regenerating Gene) / rig (Rat Insulinoma Gene) / Mosaic Evolution / Pancreatic Polypeptide Gene / Peptidylglycine alpha-Amidating Enzyme / Phorbol Ester-Responsive Element / Cyclic AMP / VIP Gene / Vasoactive Intestinal Peptide(VIP) / Phorbol esters / 膵B細胞腫 / PHM-27mRNA / インスリン / PHM-27遺伝子 / VIP / genomic ライブラリー / 種間保存 / インスリノーマ / rig(rat insulinoma gene) / prepro VIP mRNA / プロモーター / TATA box / pancreatic polypeptide / 再生膵B細胞 / nuclear oncogene / アンチセンスオリゴヌクレオチド / インスリーノーマ遺伝子 / reg / oncogene / housekeeping gene / rig / cyclic AMP@phorbol ester-responsive element / 酸素添加酵素 / pancreatic thread protein / pancreatic stone protein / rig遺伝子 / reg遺伝子 / ペプチドC末端αーアミド化酵素 / cyclic AMP@phorbol ester-responsive element結合因子 / 膵ランゲルハンス島β細胞 / reg(Regenerating Gene) / rig(Rat Insulinoma Gene) / モザイク進化 / Pancreatic Polypeptide遺伝子 / ペプチドC末端α-アミド化酵素 / Cyclic AMP@Phorbol Ester-Responsive Element / VIP遺伝子 / molecular cloning / Ca^<2+> release channel / Ca^<2+>放出チャンネル / Ca2^+放出チャンネル / Genetic engineering / Peptidyamidoglycolate lyase / Monooxygenase / Peptidylglycine hydroxylase / Reconstitution / Two-step mechanism / C-terminal alpha-amidation / 分泌 / トランスフェクション / cDNA / 発現ベクタ- / 発現ベクター / ヒスチジン / ペプチドC末端アミド化酵素 / PHM-27 / 水酸化グリシン脱アルキルアミド化酵素 / 再構成系 / 遺伝子組換え法 / ペプチジルアミドグリコレートリアーゼ / モノオキシゲナーゼ / ペプチジルグリシン水酸化酵素 / 2段階反応 / ペプチドC末端アミド化 / 遺伝子組換え / トランスジェニックマウス / 糖尿病 / 再生増殖 / インスリン産生細胞 / 染色体座位 / 遺伝子ファミリー / Gene targeting / Transgenic mouse / Regeneration / Pancreatic islet β-cells / Reg / Ca2+mobilization / Ca^<2+>mobilization / Ca^<2+> mobilization … More Except Principal Investigator CD38 / Cyclic ADP-ribose / REG遺伝子 / CICR / FKBP12.6 / V-ATPase / ATP / Insulin secretion / Ca^<2+> mobilization / Second messenger / 発現制御 / 糖尿病 / 遺伝子 / 胃がん / 大腸・直腸がん / 転写調節 / REG遺伝子ファミリー / インスリン産生細胞 / Reg / 再生増殖 / Reg遺伝子 / Reg蛋白質 / regeneration of pancreatic <beta>-cells / aromatic acid amides / oxygen radicals / insulin-dependent diabetes / streptozotocin / alloxan / 90 % depancreatized rats / DNA複製 / ラジカルスカベンジャー / 芳香族酸アミド / 膵切除ラット / 糖尿病治療薬 / reg(regenerating gene) / 再生膵B細胞 / 膵ランゲルハンス島 / アロキサン、ストレプトゾトシン / 糖尿病治療藥 / 膵ランゲルハンス島β細胞再生 / 芳香族酸アミド化合物 / 活性酸素 / インスリン依存性糖尿病 / ストレプトゾトシン / アロキサン / 90%膵切除ラット / Diabetic vascular complications / Insulitis / NOD mouse / 自然発症糖尿病ラット(GKラット) / 糖尿病性血管合併症 / 膵う島炎 / NODマウス / Autism / Social recognition / Splicing / Ryanodine receptor / FKBP / 循環器・高血圧 / シグナル伝達 / 自閉症 / 社会認識異常 / スプライシング / サイクリックADPリボース / リアノジン受容体 / GASTROINTESTINAL CANCER / REG RECEPTOR / REG PROTEIN / REG GENE / 免疫染色 / 定量PC / 胆管細胞癌 / Reg蛋白受容体 / 臨床病理学的検討 / REG蛋白質 / 消化器癌 / REG蛋白受容体 / REG蛋白 / nano motors / nano machine / Lisosom / F-TPase / ランゲルハンス島 / 分泌顆粒 / F型ATPase / 細胞組織 / 酵素 / 生体分子 / 蛋白質 / インスリン / ATP合成酵素 / V型ATPase / プロトンポンプ / ナノモーター / ナノマシーン / リソソーム / F-ATPase / microsome / Quantitative method / Pancreatic islet beta-cells / 抗cyclic ADP-ribose抗体 / サクシニルcyclic ADP-ribose / 測定法 / Ca2+ mobilization / cyclic ADP-ribose / 抗cyclicADP-ribose抗体 / insulin secretion / Cs^<2+>mobilization / second messenger / cyclicADP-ribose / pancreatic islet β-cells / 定量法 / Pancreatic islet β-cells / G protein / gene regulation / transduction / cell nucleus / cytoplasm / cell membrane / receptors / drugs / organella constituents / m‐RNA構造 / 細胞膜タンパク質 / 膜結合性Gキナ-ゼ / ホルモン受容体 / 脂質輸送 / 細胞膜因子 / Cキナーゼ / Gタンパク質 / 遺伝子調節 / トランスダクション / 細胞核 / 細胞質 / 細胞膜 / 受容体 / 薬物 / オルガネラ構成因子 / RFLP / インスリン遺伝子 / NONマウス / 動物モデル / インスリン非依存性糖尿病 / 細胞周期調節 / p19^<INK4D> / CDK4 / 心筋 / 再生医学 / 増殖抑制 / チアゾリジン誘導体 / レポータージーンアッセイ / ルシフェラーゼアッセイ / RT-PCR / リン酸化 / 転写活性 / cyclin D1 / 再生 / ノックアウトマウス / PI3キナーゼ / ATF-2 / サイクリンD1 / 膵β細胞 Less

Regulation of the CD38-cyclic ADP-ribose signal system by tissue-specific slicing of ryanodine receptor
- Principal Investigator
  
  TAKASAWA Shin
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
増殖因子REGを分子標的とした抗がん剤リード化合物の開発
- Principal Investigator
  
  高沢伸
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
インスリン産生細胞増殖因子RegのCDK阻害系による細胞周期調節
- Principal Investigator
  
  高沢伸
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
増殖因子REGを分子標的とした新規抗がん剤リード化合物の探索
- Principal Investigator
  
  高沢伸
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
インスリン産生細胞増殖因子Regによる細胞周期調節
- Principal Investigator
  
  高沢伸
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Reg Gene and Reg receptor Expressed in Human Gastrointestinal Cancers
- Principal Investigator
  
  UNNO Michiaki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  TOHOKU UNIVERSITY
Proton pump ATPase as nano motors
- Principal Investigator
  
  FUTAI Masamistu
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Microbial Chemistry Research Center
  Osaka University
Cyclic ADP-ribose signal transduction : Molecular mechanism and pathophsiological significancePrincipal Investigator
- Principal Investigator
  
  OKAMOTO Hiroshi
- Project Period (FY)
  1996 – 2000
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
インスリン産生細胞増殖因子Reg蛋白質を用いた糖尿病治療法の開発Principal Investigator
- Principal Investigator
  
  YONEMURA Yutaka, 岡本宏
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Kanazawa University
  Tohoku University
ATP依存性に蓄積された膵β細胞小胞体CaのサイクリックADPリボースによる放出Principal Investigator
- Principal Investigator
  
  岡本宏
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
新しい細胞内情報伝達物質サイクリックADPリボースの合成酵素と受容体の解明Principal Investigator
- Principal Investigator
  
  岡本宏
- Project Period (FY)
  1993 – 1996
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Establishment of a quantitative method for determining cyclic ADP-ribose concentration
- Principal Investigator
  
  YONEKURA Hideto
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tohoku University
Co-operative Responses of Organella Constituents to Drug stimulation
- Principal Investigator
  
  OHBA Yoshiki
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kanazawa University
Production of the two enzymes concerned in peptide C-terminal alpha-amidation by genetic engineering and in vitro reconstitution of peptide C-terminal alpha-amidation reactionPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Hiroshi
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  TOHOKU UNIVERSITY
ヒトII型糖尿病モデルNONマウスのインスリン遺伝子発現異常の解析
- Principal Investigator
  
  大角誠治
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Toyama Medical and Pharmaceutical University
Mechanisms of Regulation of Biosynthesis of Blood Sugar- and Blood Pressure-Lowering PeptidesPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Hiroshi
- Project Period (FY)
  1985 – 1989
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  TOHOKU UNIVERSITY
STUDY ON PATHOGENESIS OF DIABETES AND DIABETIC COMPLICATIONS IN DIABETIC ANIMAL MODELS
- Principal Investigator
  
  GOTO Yoshio
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  TOHOKU UNIVERSITY
Establishment of experimental models for insulin-dependent diabetes and exploitation of novel drugs for the treatment of diabetes
- Principal Investigator
  
  HYAHI Norio
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  General medical chemistry
- Research Institution
  TOHOKU UNIVERSITY

All 2005 2004

All Journal Article

[Journal Article] A novel ryanodine receptor expressed in pancreatic islets and its possible role in the cyclic ADP-ribose-induced intracellular calcium mobilization.2005
- Author(s)
  Okamoto, H.
- Journal Title
  
  Diabetologia 48
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390072
[Journal Article] A novel ryanodine receptor expressed in pancreatic islets and its possible role in the cyclic ADP-ribose-induced intracellular calcium` mobilization.2005
- Author(s)
  Okamoto, H.
- Journal Title
  
  Diabetologia 48
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390072
[Journal Article] Pancreatic beta-cell regeneration by Regenerating gene (Reg) and a possible therapeutic use of Reg gene and/or Reg protein in diabetes treatment.2005
- Author(s)
  Okamoto, H.
- Journal Title
  
  Int. J. Artificial Organs 28
  
  Pages: 329-330
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390072
[Journal Article] Pancreatic beta-cell regeneration by Regenerating gene (Reg) and a possible therapeutic use of Reg gene and/or Reg protein in diabetes treatment.2005
- Author(s)
  Okamoto, H.
- Journal Title
  
  Int.J.Artificial Organs 28
  
  Pages: 329-330
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390072
[Journal Article] A novel ryanodine receptor expressed in pancreatic islets and its possible role in the cyclic ADP-ribose-induced intracellular calcium mobilization.2005
- Author(s)
  Okamoto, H.
- Journal Title
  
  Diabetologia 48
- Data Source
  KAKENHI-PROJECT-16026203
[Journal Article] Pancreatic beta-cell regeneration by Regenerating gene (Reg) and a possible therapeutic use of Reg gene and/or Reg protein in diabetes treatment.2005
- Author(s)
  Okamoto, H.
- Journal Title
  
  Int.J.Artificial Organs 28
  
  Pages: 329-330
- Data Source
  KAKENHI-PROJECT-16026203
[Journal Article] Pancreatic β-cell regeneration by Reg gene and Reg protein.2004
- Author(s)
  Okamoto, H.
- Journal Title
  
  膵臓 19
  
  Pages: 231-231
- Data Source
  KAKENHI-PROJECT-16026203
[Journal Article] Pancreatic β-cell regeneration by Reg gene and Reg protein.2004
- Author(s)
  Okamoto H.
- Journal Title
  
  膵臓 19
  
  Pages: 231-231
- Data Source
  KAKENHI-PROJECT-14370373
[Journal Article] Pancreatic β-cell regeneration by Reg gene and Reg protein.2004
- Author(s)
  Okamoto, H.
- Journal Title
  
  膵臓 19
  
  Pages: 231-231
- Data Source
  KAKENHI-PROJECT-16023211

1. TAKASAWA Shin (50187944)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
2. NATA Koji (90202233)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. YONEKURA Hideto (80240373)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. YONEMURA Yutaka (20167042)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. YAMAMOTO Hiroshi (00115198)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 大角誠治 (90144287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 加藤弘巳 (40111744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OHBA Yoshiki (10012634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ICHIKAWA Atsushi (10025695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ISHIBASHI Sadahiko (90012616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NOMURA Yasuyuki (00034041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NATORI Shunji (50012662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 市原明 (40035374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. FUTAI Masamistu (50012646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SUN-WADA Ge-hong (00314427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 和田洋 (50212329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 三本木至宏 (10222027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. UNNO Michiaki (70282043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KATAYOSE Yu (20302151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. NOGUCHI Naoya (20333792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. GOTO Yoshio (00004565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KANAZAWA Yasunori (10010399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. TOYOTA Takayoshi (40003628)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. TARUI Seiichiro (00028341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. IMURA Hiroo (10025570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. HYAHI Norio (00004606)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OKAMOTO Hiroshi 岡本 宏

岡本 宏 オカモト ヒロシ

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cyclic ADP-ribose signal transduction : Molecular mechanism and pathophsiological significancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

インスリン産生細胞増殖因子Reg蛋白質を用いた糖尿病治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ATP依存性に蓄積された膵β細胞小胞体CaのサイクリックADPリボースによる放出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

新しい細胞内情報伝達物質サイクリックADPリボースの合成酵素と受容体の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Production of the two enzymes concerned in peptide C-terminal alpha-amidation by genetic engineering and in vitro reconstitution of peptide C-terminal alpha-amidation reactionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

OKAMOTO Hiroshi 岡本宏

岡本宏オカモトヒロシ