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FUJII Kohyu  藤井 宏融

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… Alternative Names

藤井 安融  フジイ コウユウ

藤井 広融  フジイ コウユウ

藤井 弘融  フジイ コウユウ

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Researcher Number 60034021
Other IDs
External Links
Affiliation (based on the past Project Information) *help 1999: Faculty of Medicine, Anesthesiology, Hiroshima University, Associate Professor, 医学部(平成11年3月31日付辞職), 講師
1987 – 1998: Hiroshima University, School of Medicine, 医学部, 講師
1990: 広島大学, 医学部・麻酔・蘇生学教室, 講師
1990: Hiroshima University, School of Medicine Assistant Professor, 医学部・麻酔蘇生学教室, 講師
1989: 広島大学, 医学部麻酔学教室, 講師
1986: Hiroshima University School of Medicine, Assistant Professor, 医学部, 助手
Review Section/Research Field
Principal Investigator
Anesthesiology/Resuscitation studies / 麻酔学
Except Principal Investigator
麻酔学 / Anesthesiology/Resuscitation studies / 外科・放射線系歯学
Keywords
Principal Investigator
吸入麻酔薬 / Halothane / 肝障害 / ハロタン / Anesthetics / Hepatotoxicity / 脂質過酸化 / ハロセン / イソフルラン / 還元反応 … More / 四塩化炭素 / Free Radical / Dehalogenation / Lipid Peroxydation / Anesthetic / ラジカル / ラジカル反応 / 嫌気的脱ハロゲン化反応 / guinea pig / trypan blue uptake / hepatocytes / liver injury / inositoltrisphosphate / intracellular Ca2_+ / カルシムイオン / 肝細胞内カルシウム / 吸入麻酔葉 / モルモット / トリパンブルー / 肝炎 / イノシトール3リン酸 / 細胞内カルシウム / Carbon Tetrachloride / Sevoflurane / enflurane / Isoflurane / Enhancement / 代謝活性 / セボフルラン / エンフルラン / 代謝亢進 / Reduction / Lipid peroxidation / 肝ミクロソーム / 脱ハロゲン化反応 / ハロアルカン / シトクロムP450 … More
Except Principal Investigator
吸入麻酔薬 / 悪性高熱症 / ハロセン / Malignant Hyperthermia / セボフルレン / Halothane / Ca-induced Ca release / 肝障害 / Skinned Fiber Test / Statistical Analysis / Ca-induced Ca release(CICR) / スキンドファイバー法 / 統計的解析 / PCR / Sevoflurane / Kd / Bmax / c-AMP / Reoxygenation / Hypoxia / Malignant hyperthermia / Incidence of MH in Japan / Local anesthetics narcotics / Volatile narcotics / Normal range of human skeletal muscle / Ca^<2+>-induced Ca^<2+> release (CICR) / 悪性症候群 / Ca-tnduced Ca release(CICR) / 正常値 / アルコ-ル類 / 麻酔系鎮痛薬 / ヒト正常値 / Ca^<2+>ーinduced Ca^<2+> release(CICR) / 発症頻度 / 統計学的解析 / 局所麻酔薬 / ヒト骨格筋:正常値 / スキンドファイバ-法 / ^<2+>ーinduced Ca^<2+> release(CICR) / Metabolite / Inorganic Fluoride / Enflurane / 薬動力学 / フッ素 / エンフルレン / 代謝産物 / 無機フッ素 / Dehalogenation / Enzyme Inhibition / Enzyme Induction / Anesthetic / バルビツレート / 脱ハロゲン化反応 / 酵素阻害 / 酵素誘導 / 臓器特異性 / Membrane Fluidity / HLA typing / 麻酔合併症 / 膜流動性 / HLAタイピング / Decomposition / Sodalime / Isoflurane Sevoflurane / Volatile Anesthetic / 不純物 / フッ素イオン / トリフルオロ酢酸 / ソーダライム / イソフルレン / 代謝 / 分解 / Genetic linkage study / Screening test of MH / Caltured human skeletal muscle cell / [CaィイD12+ィエD1]i / Caffeine / Ca-induced-Ca Release Rate / スクリーニングテスト / 骨格筋リアノジン遺伝子 / CICR速度 / カルシウムイオン画像解析 / 遺伝子解析 / カルシウム動態 / 骨格筋細胞 / Ca-inducede-Ca release / Skinned fiber / Skeletal muscle / Genetic linkage analysis / Gene / リアノジン受容体 / スキンドファイバー / 骨格筋 / 連鎖解析 / 遺伝子 / GTPgammaS / Adenyl cyclase / Beta-adrenoceptor / GTP binding protein / GTPγS / アデニル酸シクラーゼ活性 / フォルスコリン / GTPアナログ / アデニル酸シクラーゼ / G蛋白質 / β-アドレナリン受容体-共役系 / 心室筋 / 揮発性吸入麻酔薬 / C-AMP / フオルスコリン / アデニール酸シクラーゼ / β-アドレナリン受容体 / 心筋 / Sevoflurance / Isoflurane / Intracellular Ca^<2+> concentration / Isolated hepatocytes / Guinea pig / 細胞内CA^<2+>濃度 / セボフルラン / イソフルラン / 細胞内Ca^<2+>濃度 / 分離肝細胞 / モルモット / NADPH oxidase / Intra-cellular Ca^<++> ion / Superoxide anion / Neutrophils / チトクロ-ムC還元法 / 抗ショック薬 / 虚血ー再還流 / カルシュ-ムイオン / 好中球 / hypoxia / 盧血・再潅流 / 細胞内Ca^2濃度 / 活性酸素 / 虚血・再灌流 / NADPHオキシデース / 細胞内Ca^サの濃度 / 浮性酸素 / ヒト好中球 / Microsomes / Reduction / Cytochrome P450 / Lipid Peroxidation / Anesthetics / 嫌気的代謝 / 四塩化炭素 / ペンタン / 肝ミクロソ-ム / 肝ミクロソーム / 肝ミクロリーム / 還元反応 / チトクロムP450 / 脂質過酸化 / Sarwplasmic Reticulum / procine stress syndrome (PSS) / Pietrain / スキンド骨格筋線維 / PSSブタ / カルシウムによるカルシウム放出速度 / ハロセンテスト / ピエトレン種豚 / P.S.S.豚 / カルシウムによるカルシウム放出 / 筋小胞体 / P.S.S豚 / ピエトレン / ニカルジピン / ジルチアゼム / ベラパミ-ル / カルシウム拮抗薬 Less
  • Research Projects

    (18 results)
  • Co-Researchers

    (26 People)
  •  Study on intracellular calsium on guine pig liver electron traspor system and sytosolic inositoltrisphosphatePrincipal Investigator

    • Principal Investigator
      FUJII Kohyu
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  ハロタン還元代謝中のシトクロムP450失活に関する研究Principal Investigator

    • Principal Investigator
      藤井 宏融
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Hiroshima University
  •  THE TRIAL STUDY FOR THE MINIMUM INVASIVE DIAGNOSTIC TEST FOR MHS -THE EFFECTS OF CAFFEINE AND HALOTHANE ON CULTURED HUMAN SKELETAL MUSCLE CELL MESURING INTRA CELLULAR Ca CONCENTRATION CONCENTRATION AND GENETIC ANALYSIS-

    • Principal Investigator
      YUGE Osafumi
    • Project Period (FY)
      1996 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Hiroshima University
  •  Study on the effect of inhalation anesthetics on guine pig liver clectron traspor systemPrincipal Investigator

    • Principal Investigator
      FUJII Kohyu
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Analysis of genetic linkage in malignant hyperthermia susceptible families in Japan

    • Principal Investigator
      KAWAMOTO Masashi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Effects of bolorile anesthetics in isolated myocordial beta-adrenergic receptor transmission

    • Principal Investigator
      YUGE Osafumi
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Effects of Volatile Anesthetics on the Intracellular Ca^<2+> Concentration

    • Principal Investigator
      KAWAHARA Michio
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      外科・放射線系歯学
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Comparative study of anesthetics on microsomal lipid peroxidation

    • Principal Investigator
      MORIWAKI Katsuyuki, SATO Nobuyoshi, 盛生 倫生
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      麻酔学
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Study on lipid Reroxidation by halothane and its inhibitionPrincipal Investigator

    • Principal Investigator
      FUJII Kohyu
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      麻酔学
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Effects of hypoxia-reoxygenation on superoxide production and change of intra-cellular Ca^<++> of neutrophils

    • Principal Investigator
      YUGE Osafumi
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      麻酔学
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  カルシウム拮抗薬のハロセン肝障害に及ぼす影響

    • Principal Investigator
      KAWAHARA Michio
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      外科・放射線系歯学
    • Research Institution
      Hiroshima University
  •  Establishment of an animal model for Malignant hyperthermia

    • Principal Investigator
      YUGE Osafumi, MORIO Michio
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      麻酔学
    • Research Institution
      Hiroshima University
  •  Basic Studies on the Excretion of Inorganic Fluoride, a Metabolite Volatile Anesthetics

    • Principal Investigator
      MUKAIDA Keiko
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      麻酔学
    • Research Institution
      Hiroshima University
  •  Studies on the Prophylaxis, the Diagnosis and the Treatment of Malignant Hyperthermia

    • Principal Investigator
      FUJIOKA Yasuhiro
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      麻酔学
    • Research Institution
      Hiroshima University
  •  Anaerobic halothane Dehalogenation in extra hepatic organe and Enzyme induction and Enzyme Inhibition.

    • Principal Investigator
      MORIO Michio
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      麻酔学
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Halothane induced Lipid perosidation and HepatotoxicityPrincipal Investigator

    • Principal Investigator
      FUJII Kohyu
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      麻酔学
    • Research Institution
      Hiroshima University
  •  Studies on the Diagnosis and the Treatment of Malignant Hyperthermia

    • Principal Investigator
      FUJIOKA Yasuhiro, 菊地 博達, 菊地 博逹
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      麻酔学
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Studies on Impurity, Decomposition and Biotransformation of Volatile Anesthetics

    • Principal Investigator
      MORIO Michio
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      麻酔学
    • Research Institution
      HIROSHIMA UNIVERSITY
  • 1.  MORIO Michio (80033950)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 2.  YUGE Osafumi (40034128)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 3.  KIKUCHI Hirosato (40034029)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 4.  MUKAIDA Keiko (20182066)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  SATO Nobuyoshi (30225982)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  NAKAO Masakazu (90164128)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  MORIWAKI Katsuyuki (30157937)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  KAWAMOTO Masashi (40127642)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  OOSAWA Yasuhiro (00263682)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  KAWAHARA Michio (30034094)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  ISHIHARA Shin (00106808)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  FUJIOKA Yasuhiro (00192310)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  KINOSHITA Hiroyuki (60136083)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  MTSUBARA Toshimitu (50063954)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  KINUGAWA Hiroshi (00177883)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  YAMANOUE Takao (10174765)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  MAEHARA Yasuhiro (20238877)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  ARAI Keiko (30167978)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  FUKUDA Yasuhiko (40093801)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  NAKATANI Keio (30192222)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  AKITA Susumu (40175790)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  KUBOTA Minoru (00221226)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  河内 正治 (60152972)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  木下 博之 (00127515)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  EBI Shigenao
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  海老 茂直
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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