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SEKI Koh-ichi  関 興一

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… Alternative Names

関 與一  セキ コウイチ

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Researcher Number 60094835
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2003 – 2010: 北海道大学, アイソトープ総合センター, 教授
2008: 北海道大学, 学内共同利用施設, 教授
2003: 北海道大学, アイソトープセンター, 教授
2002: 北海道医療大学, 薬学部, 教授
Review Section/Research Field
Principal Investigator
Radiation science
Except Principal Investigator
Radiation science / Radiation science / Biological Sciences
Keywords
Principal Investigator
PET / tumor / [11C]5-FU / [11C]phogne / imaiing tracer / thymidine phosphorylase / angiogenesis factor / angiogenesis / β-アミノメタクリルアミド誘導体 / 2-^<11>C-チミジン … More / ^<11>C-ホスゲン / 陽電子放出画像診断薬剤 / 細胞増殖能評価薬剤 / 5-Bromo-6-[2-(oxoimidazolidinyl)methyl]uracil / Thymidine Phosphorylase / 放射性標識薬剤 / 腫瘍診断薬剤 / イメージング剤 / 腫瘍 / [^<11>C]phosgene / 核医学診断薬剤 / チミジンフォスフォリラーゼ / 血管新生因子 / 血管新生 … More
Except Principal Investigator
放射線 / 分子イメージング / プロスタグランジン / 腫瘍 / ポジトロンCT / 核医学診断 / 癌 / PET / 低酸素細胞 / ポジトロンCT(PET) / シングルフォトンCT(SPECT) / シクロオキシゲナーゼ(COX-2) / Tumor / Nuclear medicine / Radiopharmaceuticals / Nucleic acid / 核酸 / Therapy / Molecular imaging / Cancer / Radioisotope / 治療 / stereoselective synthesis / imaging / single photon computed tomography / nucleoside / nitroimidazole / hypoxia / 低酸素細胞親和性 / 生体内分布 / 立体選択的合成 / イメージング / X線結晶構造解析 / ヌクレオシド / シングルフォトンCT / 腫瘍診断薬剤 / ニトロイミダゾール / single photon CT (SPECT) / positron CT (PET) / cyclooxygenase-2(COX-2) / prostaglandins / molecular imaging / pathophysiology of cerebral ischemia / シクロオキシナーゼ(COX-2) / 脳虚血病態 / 血管新生 / 臨床 / 生体分子 / ポジトロン / 分子標的治療 / FDG / マイクロビーム / 定位放射線治療 / 4次元放射線治療 / 画像誘導放射線治療 / スポットスキャン / 動体追跡放射線治療 / 核医学診断技術 / 放射線治療 / シンロオキシゲナーゼ(COX-2) / 動脈硬化 / シクロオキシゲナーゼ / チミジン / 核酸合成 / 鑑別診断 / 炎症 / インビボイメージング Less
  • Research Projects

    (10 results)
  • Research Products

    (72 results)
  • Co-Researchers

    (32 People)
  •  Molecular imaging for dynamic analysis of cancer pathological states : Toward clinical molecular imaging

    • Principal Investigator
      KUGE Yuji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Hokkaido University
  •  Development of a radiolabeled uracil derivative as a potential PET tracer for angiogenesis imaging.

    • Principal Investigator
      OHKURA Kazue
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Health Sciences University of Hokkaido
  •  Basic Research for four-dimensional stereotactic radiotherapy

    • Principal Investigator
      SHIRATO Hiroki
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Molecular imaging and strategies for cancer treatment: A Study to achieve noninvasive in vivo pathological evaluation by molecular imaging

    • Principal Investigator
      KUGE Yuji
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Hokkaido University
      Kyoto University
  •  Development of PET radiopharmaceuticals for pyrimidine'nucleotide metabolic imaging

    • Principal Investigator
      OHKURA Kazue
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Health Sciences University of Hokkaido
  •  動脈硬化病態の解析と分子イメージング:プロスタグランジン合成酵素を標的として

    • Principal Investigator
      久下 裕司
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Radiation science
    • Research Institution
      Kyoto University
  •  Fundamental Studies on the Development of New Diagnostic Radio Tracers Targeting Angiogenesis FactorsPrincipal Investigator

    • Principal Investigator
      SEKI Koh-ichi
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Hokkaido University
  •  Development of novel labeled nucleosides for spect imaging of tumor tissue.

    • Principal Investigator
      OHKURA Kazue
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Health Sciences University of Hokkaido
  •  核酸合成・PG合成酵素のインビボイメージング:腫瘍・炎症の鑑別診断への挑戦

    • Principal Investigator
      KUGE Yuji
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Radiation science
    • Research Institution
      Kyoto University
  •  Molecular imaging and patho-functional analysis of cerebral ischemia : focused on prostaglandin synthases

    • Principal Investigator
      KUGE Yuji
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      KYOTO UNIVERSITY

All 2010 2009 2008 2007 2006 2004 2003

All Journal Article Presentation Patent

  • [Journal Article] In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging.2010

    • Author(s)
      Akizawa H, Zhao S, Takahashi M, Nishijima K, Kuge Y, Tamaki N, Seki K, Ohkura K
    • Journal Title

      Nucl Med Biol. 37

      Pages: 427-432

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390320
  • [Journal Article] New [^<11>C] phosgene based synthesis of [^<11>C] pyrimidines for positron emission tomography2009

    • Author(s)
      Seki K., Nishijima K., Sanoki K., Kuge Y., Takahashi M., Akizawa H., Tamaki N., Wiebe LI., Ohkura K.
    • Journal Title

      Heterocycles 77

      Pages: 1307-1321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591457
  • [Journal Article] New [11C] phosgene based synthesis of [11C]- pyrimidines for positron emission tomography2009

    • Author(s)
      Seki K., Nishijima K., Sanoki K., Kuge Y., Takahashi M., Akizawa H., Tamaki N., Wiebe LI., Ohkura K.
    • Journal Title

      Heterocycles 77

      Pages: 1307-1321

    • Data Source
      KAKENHI-PROJECT-20591457
  • [Journal Article] Splenic peliosis mimicking a solid tumor : findings in multimodalities2008

    • Author(s)
      Abo D, Terae S, Fukasawa Y, Seki H, Hasegawa Y, Sakuhara Y, Shimizu T, Shirato H
    • Journal Title

      J Comput Assist Tomogr 32

      Pages: 890-892

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016002
  • [Journal Article] Synthesis of ^<11>C-labeled uracil derivative for a PET tracer targeting thymidme phosphorylase2008

    • Author(s)
      M.Takahashi, K.Seki, K.Nishijima, Y.Kuge, N.Tamaki, K.Ohkura
    • Journal Title

      Heterocycles 76(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Journal Article] New [11C]phosgene based [11C] pyrimidines for Positron emission tomography.2008

    • Author(s)
      Seki K, Nishijima K, Sanoki K, Kuge Y, Takahashi M, Akizawa H, Tamaki N, Wiebe L, Ohkura K
    • Journal Title

      Heterocycles 77

      Pages: 1307-1321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016002
  • [Journal Article] Synthesis of ^<11>C-labeled uracil derivative for a PET tracer targeting thymidine phosphorylase2008

    • Author(s)
      M. Takahashi, K. Seki, K. Nishijima, Y. Kuge, N. Tamaki, K. Ohkura
    • Journal Title

      Heterocycles 76(in press)

    • NAID

      40016208568

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Journal Article] New [^<11>C]phosgene based [^<11>C] pyrimidines for Positron emission tomograpby2008

    • Author(s)
      Koh-ichi Seki
    • Journal Title

      Heterocycles 77

      Pages: 1307-1321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016002
  • [Journal Article] Synthesis of 11C-labeled uracil derivative for a PET tracer targeting thymidine phosphorylase2008

    • Author(s)
      M. Takahashi, K Seki, K.Nishijima, Y. Kuge, N. Tamaki, K. Ohkura
    • Journal Title

      Heterocycles 76(in press)

    • NAID

      40016208568

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Journal Article] Synthesis of ^<11>C-labeled uracil derivative for a pet tracer targeting thymidine phosphorylase.2008

    • Author(s)
      Takahashi M., Seki K., Nishijima K., Kuge Y., Tamaki N., Ohkura K.
    • Journal Title

      Heterocycles 76

      Pages: 237-241

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591457
  • [Journal Article] Splenic peliosis mimicking a solid tumor: findings in multimodalities.2008

    • Author(s)
      Abo D, Terae S, Fukasawa Y, Seki H, Hasegawa Y, Sakuhara Y, Shimizu T, Shirato H
    • Journal Title

      J Comput Assist Tomogr 32

      Pages: 890-892

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016002
  • [Journal Article] Synthesis of 11C-labeled uracil derivative for a pet tracer targeting thymidine phosphorylase2008

    • Author(s)
      Takahashi M., Seki K., Nishijima K., Kuge Y., Tamaki N., Ohkura K.
    • Journal Title

      Hetero- cycles 76

      Pages: 237-241

    • Data Source
      KAKENHI-PROJECT-20591457
  • [Journal Article] A novel and efficient synthesis of [2-11C]5-fluorouracil for prognosis of cancer chemotherapy.2007

    • Author(s)
      Seki K, et. al.
    • Journal Title

      Pharm Pharmaceut Sci 10(2)

      Pages: 181-185

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390332
  • [Journal Article] A novel and efficient synthesis of [2-11C] 5-fluorouracil for prognosis of cancer chemotherapy.2007

    • Author(s)
      Seki K, et. al.
    • Journal Title

      J Pharm Pharmaceut Sci. 10(2)

      Pages: 181-185

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390332
  • [Journal Article] A novel and efficient synthesis of [2-^<11>C]5-fluorouracil for prognosis of cancer chemotherapy2007

    • Author(s)
      K. Seki, K. Nishijima, Y. Kuge, N. Tamaki, L. I. Wiebe, K. Ohkura
    • Journal Title

      J. Pharm. Pharm. Sci 10

      Pages: 210-214

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Journal Article] A novel and efficient synthesis of [2-^<11>C]5-fluorouracil for prognosis of cancer chemotherapy2007

    • Author(s)
      K.Seki, K.Nishijima, Y.Kuge, N.Tamaki, L.I.Wiebe, K.Ohkura
    • Journal Title

      J. Pharm. Pharm. Sci. 10

      Pages: 210-214

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] A novel and efficient synthesis of [2-^<11>C]5-fluorouracil for prognos is of cancer chemotherapy2007

    • Author(s)
      K.Seki, K.Nishijima, Y.Kuge, N.Tamaki, L.I.Wiebe, K.Ohkura
    • Journal Title

      J. Pharm. Pharm. Sci 10

      Pages: 210-214

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Journal Article] A novel and efficient synthesis of [2-11C]5-fluorouracil for prognosis of cancer chemotherapy2007

    • Author(s)
      K. Seki, K. NIshijima, Y. Kuge, N. Tamaki, L. Wiebe, K. Ohkura
    • Journal Title

      J Pharm Pharmaceut Sci 10

      Pages: 212-216

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Journal Article] A new convenient method for the synthesis of [2-^<11>C]thymine utilizing [^<11>C]phosgene2007

    • Author(s)
      Kazue Ohkura, Koh-ichi Seki, et al.
    • Journal Title

      J. Pharm. Pharm. Sci. 10 (2)

      Pages: 181-185

    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] A novel and efficient synthesis of [2-^<11>C]5-fluorouracil for prognosis of cancer chemotherapy2007

    • Author(s)
      Koh-ichi Seki^<1, *>, Ken-ichi Nishijima^2, Yuji Kuge^3, Nagara Tamaki^3, Leonard I. Wiebe^4, Kazue Ohkura^<2, *>
    • Journal Title

      J. Pharm. Pharm. Sci. 10 (2)

      Pages: 210-214

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] A novel and efficient synthesis of[2-^<11>C]5-fluorouracil for prognosis of cancer chemotherapy.2007

    • Author(s)
      Seki, K, et. al.
    • Journal Title

      J Pharm Pharmaceut Sci 10(2)

      Pages: 212-216

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016002
  • [Journal Article] A novel and efficient synthesis of [2-11C]5-fluorouracil for prognosis of cancer chemotherapy.2007

    • Author(s)
      Seki K, Nishijima K, Kuge Y, Tamaki N, Wiebe LI, Ohkura K
    • Journal Title

      J Pharm Pharmaceut Sci. 10(2)

      Pages: 181-185

    • Data Source
      KAKENHI-PROJECT-17390332
  • [Journal Article] Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenas-2 expression2006

    • Author(s)
      Y. Kuge, Y. Katada, S. Shimonaka, T. Temma, H. Kimura, Y. Kiyono, C. Yokota, K. Minematsu, K. Seki, N. Tamaki, K. Ohkura, H. Saji
    • Journal Title

      Nuclear Medicine and Biology 33

      Pages: 21-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Journal Article] Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibit ors as potential SPECT tracers for cyclooxygenas-2 expression2006

    • Author(s)
      Y.Kuge, Y.Katada, S.Shimonaka, T.Temma, H.Kimura, Y.Kiyono, C.Yokota, K.Minematsu, K.Seki, N.Tamaki, K.Ohkura H.Saji
    • Journal Title

      Nuclear Medicine and Biology 33

      Pages: 21-27

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Journal Article] [^<11>C]ホスゲンを用いた核酸系PET薬剤の合成法の開発2006

    • Author(s)
      関 興一, 他
    • Journal Title

      放射線生物研究 41・4

      Pages: 387-398

    • NAID

      40015265465

    • Data Source
      KAKENHI-PROJECT-17016002
  • [Journal Article] A new convenient method for the synthesis of [2-^<11>C]thymine utilizing [^<11>C]phosgene2006

    • Author(s)
      K.Ohkura, K.Nishijima, K.Sanoki, Y.Kuge, N.Tamaki, Koh-ichi Seki
    • Journal Title

      Tetrahedron Lett. 2006

      Pages: 5321-5323

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] [^<11>C]ホスゲンを用いた核酸系PET薬剤の合成法の開発2006

    • Author(s)
      関 興一, 西嶋 剣一, 大倉 一枝
    • Journal Title

      放射線生物研究、 41・4

      Pages: 387-398

    • NAID

      40015265465

    • Data Source
      KAKENHI-PROJECT-17591288
  • [Journal Article] A new convenient method for the synthesis of [2-^<11>C]thymineuti lizing [^<11>C]phosgene2006

    • Author(s)
      K.Ohkura, K.Nishijima, K.Sanoki, Y.Kuge, N.Tamaki, K.Seki
    • Journal Title

      Tetrahedron Lett 47

      Pages: 5321-5323

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Journal Article] Photochemical synthesis of polycyclic pyrimidines through the acid catalyzed cycloaddition of 6-chloro-1-methyluracil to methyl substituted bezenes.2006

    • Author(s)
      Ohkura K, Yamaguchi T, Nishijima K, Kuge Y, Seki K
    • Journal Title

      Heterocycles. 70

      Pages: 501-508

    • Data Source
      KAKENHI-PROJECT-17390332
  • [Journal Article] A new convenient method for the synthesis of [2-11C]thymine utilizing [11C]phosgene.2006

    • Author(s)
      Ohkura K, Nishijima K, Sanoki K, Kuge Y, Tamaki N, Seki K
    • Journal Title

      Tetrahedron Letters. 47

      Pages: 5321-5323

    • Data Source
      KAKENHI-PROJECT-17390332
  • [Journal Article] A new convenient method for the synthesis of [2-^<11>C]thymine utilizing [^<11>C]phosgene2006

    • Author(s)
      Kazue Ohkura, Koh-ichi Seki, et al.
    • Journal Title

      Tetrahedron Lett. 2006

      Pages: 5321-5323

    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] [^<11>C]ホスゲンを用いた核酸系PET薬剤の合成法の開発2006

    • Author(s)
      関 興一, 西嶋 剣一, 大倉 一枝
    • Journal Title

      放射線生物研究 41・4

      Pages: 387-398

    • NAID

      40015265465

    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] Synthesis of N1, N3-free pyrimidine bridged polycyclic compounds via photo-DIELS- ALDER reaction of N,N-diacetyl 5-fluorouracil with naphthalenes2006

    • Author(s)
      Kazue Ohkura, Koh-ichi Seki, et al.
    • Journal Title

      Heterocycles 69

      Pages: 515-520

    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenas-2 expression2006

    • Author(s)
      Yuji Kuge, Koh-ichi Seki, et al.
    • Journal Title

      Nuclear Medicine and Biology 33,1

      Pages: 21-27

    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenas-2 expression2006

    • Author(s)
      Yuji Kuge, Yumiko Katada, Sayaka Shimonaka, Takashi Temma, Hiroyuki Kimura, Yasushi Kiyono, Chiaki Yokota, Kazuo Minematsu4, Koh-ichi Seki5, Nagara Tamaki6, Kazue Ohkura7, Hideo Saji
    • Journal Title

      Nuclear Medicine and Biology 3 (1)

      Pages: 21-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] Synthesis of N1,N3-free pyrimidine bridged polycyclic compounds via photo-DIELS-ALDER reaction of N, N-diacetyl 5-fluorouracil with naphthalenes, Heterocycles2006

    • Author(s)
      Kazue Ohkura, Tetsuya Ishihara, James M. Diakur, Koh-ichi Seki
    • Journal Title

      Heterocycles 69

      Pages: 515-520

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] Synthesis of N1, N3-free pyrimidine bridged polycyclic compounds via photo-DIELS- ALDER reaction of N,N-diacetyl 5-fluorouracil with naphthalenes2006

    • Author(s)
      K.Ohkura, T.Ishihara, J.M.Diakur, K.Seki
    • Journal Title

      Heterocycles 69

      Pages: 515-520

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenas-2 expression2006

    • Author(s)
      Y.Kuge, Y.Katada, S.Shimonaka, T.Temma, H.Kimura, Y.Kiyono, C.Yokota, K.Minematsu, Koh-ichi Seki, N.Tamaki, K.Ohkur, H.Saji
    • Journal Title

      Nuclear Medicine and Biology 3

      Pages: 21-27

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] A new convenient method for the synthesis of[2-^<11>C]thymine utilizing[^<11>C]phosgene2006

    • Author(s)
      K. Ohkura, K. Nishijima, K. Sanoki, Y. Kuge, N. Tamaki, K. Seki
    • Journal Title

      Tetrahedron Letters 47

      Pages: 5321-5323

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Journal Article] A new convenient method for the synthesis of [2-11C]thymine utilizing [11C]phosgene2006

    • Author(s)
      Kazue Ohkura, Ken-ichi Nishijima, Kimihito Sanoki, Yuji Kuge, Nagara Tamaki, Koh-ichi Seki
    • Journal Title

      Tetrahedron Lett.

      Pages: 5321-5323

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] (2S)-2-[1-(2,4-Difluoro-5-iodophenyl)-2-deoxy-β-D-ribofuranos-5-yl]-8-methyl-4H-1,3,2,benzodioxaphosphole 2-oxide.2004

    • Author(s)
      K.Ohkura, W.Y.Sun, K.Seki, E.E.Knaus, L.I.Wiebe
    • Journal Title

      Acta Cryst., C 60

      Pages: 789-791

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591297
  • [Journal Article] (2S)-2-[1-(2,4-Difluoro-5-iodophenyl)-2-deoxy-[3-D-ribofuranos-5-yl]-8-methyl-4H-1,3,2- benzodioxaphosphole-2-oxide2004

    • Author(s)
      K.Ohkura, W.Y.Sun, K.Seki, E.E.Knaus, L.I.Wiebe
    • Journal Title

      Acta Cryst C60

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591297
  • [Journal Article] Preparation and Pre-clinical Evaluation of High Specific Activity S-(-)[^<11>C]CGP-12177, a Radioligand for β-Adrenoreceptors2004

    • Author(s)
      K.Nishijima, Y.Kuge, N.Motoki, K.Seki, K.Ohkura, E.Tsukamoto, K.Morita, N.Tamaki
    • Journal Title

      Nuclear Medicine Communications 25

      Pages: 845-849

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] (2S)-2-[1-(2,4-Difluoro-5-iodophenyl)-2-deoxy-β-D-ribofuranos-5-yl]-8-methyl-4H-1,3,2-benzodioxaphosphole 2-oxide.2004

    • Author(s)
      K.Ohkura, W.Y.Sun, K.Seki, E.E.Knaus, L.I.Wiebe
    • Journal Title

      Acta Cryst., C 60

      Pages: 789-791

    • Data Source
      KAKENHI-PROJECT-15591297
  • [Journal Article] (2S)-2[1-(2,4-Difluoro-5-iodphenyl)-2-deoxy-β-D-ribofuranos-5-yloxy]-8-methyl-4H-1,3,2-benzodioxaphosphole 2-oxide2004

    • Author(s)
      K.Ohkura, W.Y.Sun, K.Seki, E.E.Knaus, L.I.Wiebe
    • Journal Title

      Acta Crystallographica, Section C : Crystal Structure Communications C60

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] Synthesis and Antiviral Activity of Novel Fluorinated 2',3'-Dideoxynucleoside2004

    • Author(s)
      P.Kumar, K.Ohkura, J.Balzarini, E.De Clercq, K.Seki, L.I.Wiebe
    • Journal Title

      Nucleosides, Nucleotides & Nucleic Acids 23

      Pages: 7-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591297
  • [Journal Article] (2S)-2[1-(2,4-Difluoro-5-iodpheny1)-2-deoxy-□-D-ribofurano s-5-yloxy]-8-methyl-4H-1,3,2-benzodioxaphosphole 2-oxide2004

    • Author(s)
      Kazue Ohkura, Wei Yan Sun, Koh-ichi Seki, Edward E. Knaus, Leonard I. Wiebe
    • Journal Title

      Acta Crystallographica, Section C : Crystal Structure Communications C60 (11)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] Preparation and Pre-clinical Evaluation of High Specific Activity S-(-)[^<11>C]CGP-12177, a Radioligand for □-Adrenoreceptors2004

    • Author(s)
      Ken-ichi Nishijima, Yuji Kuge, Noriko Motoki, Koh-ichi Seki, Kazue Ohkura, Eriko Tsukamoto, Kohich Morita, Nagara Tamaki
    • Journal Title

      Nuclear Medicine Communications 25 (8)

      Pages: 845849-845849

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591179
  • [Journal Article] Synthesis and Antiviral Activity of Novel Fluorinated 2',3'-Dideoxy-nucleoside2004

    • Author(s)
      P.Kumar, K.Ohkura, J.Balzarini, E.De Clercq, K.Seki, L.I.Wiebe
    • Journal Title

      Nucleosides, Nucleotides & Nucleic Acids 23

      Pages: 7-29

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591297
  • [Journal Article] Synthesis of 1-β-D-(5-Deoxy-5-iodoarabinofuranosyl)-2-nitroimidazole (β-IAZA): A Novel Marker of Tissue Hypoxia2003

    • Author(s)
      P.Kumar, K.Ohkura, D.Beiki, L.I.Wiebe, K.Seki
    • Journal Title

      Chem.Pharm.Bull. 51

      Pages: 399-403

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591297
  • [Journal Article] Synthesis of 1-β-D-(5-Deoxy-5-iodoaribinofuranosyl)-2-nitro-imidazole). (β-IAZA) : A Novel Marker of Tissue Hypoxoa2003

    • Author(s)
      P.Kumar, K.Ohkura, D.Beiki, L.I.Wiebe, K.Seki
    • Journal Title

      Chem.Pharm.Bull. 51

      Pages: 399-403

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591297
  • [Patent] ウラシル化合物又はその塩、これらを有効成分として含有するイメージング剤、およびこれらを有効成分として含有する腫瘍診断をするためのイメージング剤2007

    • Inventor(s)
      大倉一枝、関興一、西嶋剣一、高橋正幸、久下裕司、玉木長良、趙松吉
    • Industrial Property Rights Holder
      大倉一枝、関興一、西嶋剣一、高橋正幸、久下裕司、玉木長良、趙松吉
    • Industrial Property Number
      2007-229002
    • Filing Date
      2007-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390332
  • [Patent] ウラシル化合物又はその塩、これらを有効成分として含有するイメージング剤、およびこれらを有効成分として含有する腫瘍を診断するためのイメ-ジング剤2007

    • Inventor(s)
      大倉 一枝, 関 興一, 西嶋 剣一, 高橋 正幸, 久下 裕司, 玉木 長良, 趙 松吉
    • Industrial Property Rights Holder
      大鵬薬品工業株式会社学校法人東日本学園・北海道医療大学国立大学法人北海道大学
    • Industrial Property Number
      2007-229002
    • Filing Date
      2007-09-04
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Patent] ウラシル化合物又はその塩、これらを有効成分として含有するイメージング剤、およびこれらを有効成分として含有する腫瘍を診断するためのイメージング剤2007

    • Inventor(s)
      大倉 一枝, 関 興一, 西嶋 剣一, 高橋 正幸, 久下 裕司, 玉木 長良, 趙 松吉
    • Industrial Property Rights Holder
      大鵬薬品工業株式会社学校法人東日本学園、北海道医療大学国立大学法人北海道大学
    • Industrial Property Number
      2007-229002
    • Filing Date
      2007-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Presentation] [^<11>C] phosgeneを用いるoxoimidazolidinylmethyluracilの合成とがんイメージングプローブへの応用2010

    • Author(s)
      関興一・西嶋剣一・高橋正幸・趙松吉・向田理恵・秋澤宏行・久下裕司・玉木長良・大倉一枝
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪(近畿大学)
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-20591457
  • [Presentation] A novel radiolabeled probe for molecular imaging of thymidine phosphorylase : Suppressed accumulation into tumor cells by target gene knockdown.2010

    • Author(s)
      Li H, Zhao S, Jin Y, Nishijima K, Akizawa H, Ohkura K, Seki K, Tamaki N, Kuge Y
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      Kyoto, Japan.
    • Data Source
      KAKENHI-PROJECT-20390320
  • [Presentation] [11C]phosgeneを用いるoxoimidazolidinylmethyluracilの合成とがんイメージングプローブへの応用。2010

    • Author(s)
      関興一, 他
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪(近畿大学本部キャンパス)
    • Data Source
      KAKENHI-PROJECT-20390320
  • [Presentation] [11C]phosgene を用いるoxo-imidazolidinylmethyluracil の合成とがんイメージングプローブへの応用2010

    • Author(s)
      関興一・西嶋剣一・高橋正幸・趙松吉・向田理恵・秋澤宏行・久下裕司・玉木長良・大倉一枝
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-20591457
  • [Presentation] Synthesis of a Potential SPECT Tracer for Angiogenic Enzyme Expression2008

    • Author(s)
      関興一
    • Organizer
      World Molecular Imaging Congress
    • Place of Presentation
      Acropolis Convention Center, Nice, France
    • Data Source
      KAKENHI-PROJECT-17016002
  • [Presentation] Ohkura Synthesis of a potential SPECT radiopharmaceutical targeting thymidine phosophorylase2008

    • Author(s)
      M. Takahashi, S. Zhao, K. Nishijima, Y. akuge, K. Seki, K
    • Organizer
      The 128th Annual meeting of Pharma-ceutical Society of Japan
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Presentation] チミジンボスホリラーゼ標的SPECT薬剤の合成2008

    • Author(s)
      高橋 正幸、趙 松吉、西嶋 剣一、久下 裕司、関 興一、大倉 一枝
    • Organizer
      日本薬学会第128年会(横浜)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Presentation] Synthesis of a Potential SPECT Tracer for Angiogenic Enzyme Expression Graduate School of Medicine.2008

    • Author(s)
      Seki K, Takahashi M, Zhao S, Nishijima K, Kuge Y, Tamaki N, Ohkura K
    • Organizer
      2008 World Molecular Imaging Congress
    • Place of Presentation
      Nice.
    • Data Source
      KAKENHI-PROJECT-20390320
  • [Presentation] Synthesis of a Potential SPECT Tracer for Angiogenic Enzyme Expression2008

    • Author(s)
      Seki K, et.al.
    • Organizer
      2008 World Molecular Imaging Congress
    • Place of Presentation
      Nice, The Acropolis Convention Center
    • Data Source
      KAKENHI-PROJECT-20390320
  • [Presentation] 薬学と医学を放射能でつないで2008

    • Author(s)
      関興一
    • Organizer
      バイオメディカル分析化学シンポジウム-生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      札幌、札幌コンベンションセンター
    • Data Source
      KAKENHI-PROJECT-17016002
  • [Presentation] Development of a novel and general synthesis of [2-^<11>C]pyrimidine2007

    • Author(s)
      K. Seki, K. Nishijima, K. Sanoki, Y. Kuge, N. Tamaki, K. Ohkura
    • Organizer
      JCSRC 2007 Seventh Japan-China Joint Seminar on Radiopharmaceutical Chemistry
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Presentation] Development of a novel and general synthesis of [2-^<11>C]pyrimidine2007

    • Author(s)
      K.Seki, K.Nishijima, K.Sanoki, Y.Kuge, N.Tamaki, K.Ohkura
    • Organizer
      JCSRC 2007 Seventh Japan China Joint Seminar on Radiopharmaceutical Chemistry
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Presentation] 18F-FLT but not 18F-FDG can early and dose-dependently detect antiproliferative responses of human tumor xenograft to epidermal growth factor receptor targeting with a tyrosine kinase inhibitor, gefitinib2007

    • Author(s)
      Zhao S, Kuge Y, Zhao Y, Takei T, Kanegae K. Inubushi M, Shiga T, Seki K, Tamaki N
    • Organizer
      The 54th Annual Meeting, Society of Nuclear Medicine
    • Place of Presentation
      Washington DC ワシントン条約センター
    • Year and Date
      2007-06-04
    • Data Source
      KAKENHI-PROJECT-17016002
  • [Presentation] 細胞増殖能評価、腫瘍一肉芽腫の鑑別診断における11C-methionineと18F-FDGの比較2007

    • Author(s)
      趙 松吉, 久下裕司, 趙 芫, 竹井俊樹, 加藤誠一, 鐘ヶ江香久子, 岡本祥三, 加藤千恵次, 関 興一, 玉木長良
    • Organizer
      第47回日本核医学会学術総会
    • Place of Presentation
      仙台,仙台国際センター
    • Year and Date
      2007-11-04
    • Data Source
      KAKENHI-PROJECT-17016002
  • [Presentation] 3H-FLTによる癌の分子標的療法の早期評価:胆がんマウスにおける投与量依存性の検討2007

    • Author(s)
      趙 松吉, 久下裕司, 趙 芫, 竹井俊樹, 鐘ヶ江香久子, 犬伏正幸, 志賀 哲, 加藤千恵次, 関 興一, 玉木長良
    • Organizer
      第47回日本核医学会学術総会
    • Place of Presentation
      仙台,仙台国際センター
    • Year and Date
      2007-11-05
    • Data Source
      KAKENHI-PROJECT-17016002
  • [Presentation] Development of a novel and general synthesis of 2-^<11>C]pyrimidine2007

    • Author(s)
      K. SeKi, K. Nishijima, K. SanoKi, Y. Kuge, N. Iamaki, K. Ohkura
    • Organizer
      JCSRC 2007 seventh Japan-China Joint Seminar on Radiopharmaceutical Chemistry
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591288
  • [Presentation] 細胞の増殖脳の評価及び腫瘍と肉芽腫の鑑別診断における11C-メチオニンの有用性:18F-FDGとの比較2007

    • Author(s)
      趙 松吉, 久下裕司, 小華和柾志, 趙 芫, 鐘ヶ江香久子, 関 興一, 玉木長良
    • Organizer
      第2回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      福井 福井フェニックスプラザ
    • Data Source
      KAKENHI-PROJECT-17016002
  • [Presentation] Usefulness of^<11>C-methionine in evaluating cellular proliferation and differential diagnosis of tumor and granuloma:An experimental study in comparison with 18F-FDG2007

    • Author(s)
      Zhao S, Kuge Y, Kohanawa M, Zhao Y, Kanegae K, Seki K, Tamaki N
    • Organizer
      The 54th Annual Meeting, Society of Nuclear Medicine
    • Place of Presentation
      Washington DC ワシントン条約センター
    • Year and Date
      2007-06-03
    • Data Source
      KAKENHI-PROJECT-17016002
  • 1.  TAMAKI Nagara (30171888)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 25 results
  • 2.  KUGE Yuji (70321958)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 12 results
  • 3.  OHKURA Kazue (60094827)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 46 results
  • 4.  SAJI Hideo (40115853)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  KIYONO Yasushi (50305603)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  YOKOTA Chiaki (80300979)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  ONIMARU Rikiya (80374461)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  NISHIJIMA Kenichi (60364254)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 21 results
  • 9.  飯田 靖彦 (60252425)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  SHIRATO Hiroki (20187537)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 11.  KANEKO Junichi (90333624)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  NISHIYAMA Syusuke (30333628)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KATOH Chietsugu (10292012)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 14.  AOYAMA Hidefumi (80360915)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  NISHIOKA Takeshi (80271659)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  MORITA Koichi (20210172)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  DATE Hiroyuki (10197600)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  TAKADA Eiji (00270885)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  TOMIOKA Satoshi (40237110)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  KUDO Kohsude (10374232)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  ONODERA Yuya (10272064)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  KAMISHIMA Tamotsu (10399868)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  SHIMIZU Shinichi (50463724)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 24.  SAKUHARA Yusuke (40374459)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 25.  OYAMA Noriko (70463742)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  ABO Daisuke (30399844)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 27.  TAGUCHI Hiroshi (90374454)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  ZHAO Songji (80374239)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 29.  AKIZAWA Hiromichi (90311795)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 30.  UEDA Masashi (40381967)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  河嶋 秀和 (70359438)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  向 高弘 (30284706)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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