SEKI Koh-ichi 関興一

… Alternative Names

Researcher Number	60094835
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2003 – 2010: 北海道大学, アイソトープ総合センター, 教授 2008: 北海道大学, 学内共同利用施設, 教授 2003: 北海道大学, アイソトープセンター, 教授 2002: 北海道医療大学, 薬学部, 教授
Review Section/Research Field	Principal Investigator Radiation science Except Principal Investigator Radiation science / Radiation science / Biological Sciences
Keywords	Principal Investigator PET / 血管新生 / 血管新生因子 / チミジンフォスフォリラーゼ / 核医学診断薬剤 / [^<11>C]phosgene / 腫瘍 / イメージング剤 / 腫瘍診断薬剤 / 放射性標識薬剤 … More Except Principal Investigator 分子イメージング / 放射線 / 腫瘍 / プロスタグランジン / シクロオキシゲナーゼ(COX-2) / シングルフォトンCT(SPECT) / ポジトロンCT(PET) / 低酸素細胞 / PET / 癌 / 核医学診断 / ポジトロンCT / インビボイメージング / 炎症 / 鑑別診断 / 核酸合成 / チミジン / シクロオキシゲナーゼ / 動脈硬化 / シンロオキシゲナーゼ(COX-2) / 放射線治療 / 核医学診断技術 / 動体追跡放射線治療 / スポットスキャン / 画像誘導放射線治療 / 4次元放射線治療 / 定位放射線治療 / マイクロビーム / FDG / 分子標的治療 / ポジトロン / 生体分子 / 臨床 / 血管新生 / 脳虚血病態 / シクロオキシナーゼ(COX-2) / pathophysiology of cerebral ischemia / molecular imaging / prostaglandins / cyclooxygenase-2(COX-2) / positron CT (PET) / single photon CT (SPECT) / ニトロイミダゾール / 腫瘍診断薬剤 / シングルフォトンCT / ヌクレオシド / X線結晶構造解析 / イメージング / 立体選択的合成 / 生体内分布 / 低酸素細胞親和性 / hypoxia / nitroimidazole / nucleoside / single photon computed tomography / imaging / stereoselective synthesis / 治療 / Radioisotope / Cancer / Molecular imaging / Therapy / 核酸 / Nucleic acid / Radiopharmaceuticals / Nuclear medicine / Tumor Less

Molecular imaging for dynamic analysis of cancer pathological states : Toward clinical molecular imaging
- Principal Investigator
  
  KUGE Yuji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Development of a radiolabeled uracil derivative as a potential PET tracer for angiogenesis imaging.
- Principal Investigator
  
  OHKURA Kazue
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido
Basic Research for four-dimensional stereotactic radiotherapy
- Principal Investigator
  
  SHIRATO Hiroki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Molecular imaging and strategies for cancer treatment: A Study to achieve noninvasive in vivo pathological evaluation by molecular imaging
- Principal Investigator
  
  KUGE Yuji
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
  Kyoto University
Development of PET radiopharmaceuticals for pyrimidine'nucleotide metabolic imaging
- Principal Investigator
  
  OHKURA Kazue
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido
動脈硬化病態の解析と分子イメージング:プロスタグランジン合成酵素を標的として
- Principal Investigator
  
  久下裕司
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University
Fundamental Studies on the Development of New Diagnostic Radio Tracers Targeting Angiogenesis FactorsPrincipal Investigator
- Principal Investigator
  
  SEKI Koh-ichi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Hokkaido University
Development of novel labeled nucleosides for spect imaging of tumor tissue.
- Principal Investigator
  
  OHKURA Kazue
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Health Sciences University of Hokkaido
核酸合成・PG合成酵素のインビボイメージング:腫瘍・炎症の鑑別診断への挑戦
- Principal Investigator
  
  KUGE Yuji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Kyoto University
Molecular imaging and patho-functional analysis of cerebral ischemia : focused on prostaglandin synthases
- Principal Investigator
  
  KUGE Yuji
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  KYOTO UNIVERSITY

All 2010 2009 2008 2007 2006 2004 2003

All Journal Article Presentation Patent

[Journal Article] In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging.2010
- Author(s)
  Akizawa H, Zhao S, Takahashi M, Nishijima K, Kuge Y, Tamaki N, Seki K, Ohkura K
- Journal Title
  
  Nucl Med Biol. 37
  
  Pages: 427-432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390320
[Journal Article] New [^<11>C] phosgene based synthesis of [^<11>C] pyrimidines for positron emission tomography2009
- Author(s)
  Seki K., Nishijima K., Sanoki K., Kuge Y., Takahashi M., Akizawa H., Tamaki N., Wiebe LI., Ohkura K.
- Journal Title
  
  Heterocycles 77
  
  Pages: 1307-1321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591457
[Journal Article] New [11C] phosgene based synthesis of [11C]- pyrimidines for positron emission tomography2009
- Author(s)
  Seki K., Nishijima K., Sanoki K., Kuge Y., Takahashi M., Akizawa H., Tamaki N., Wiebe LI., Ohkura K.
- Journal Title
  
  Heterocycles 77
  
  Pages: 1307-1321
- Data Source
  KAKENHI-PROJECT-20591457
[Journal Article] Splenic peliosis mimicking a solid tumor : findings in multimodalities2008
- Author(s)
  Abo D, Terae S, Fukasawa Y, Seki H, Hasegawa Y, Sakuhara Y, Shimizu T, Shirato H
- Journal Title
  
  J Comput Assist Tomogr 32
  
  Pages: 890-892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016002
[Journal Article] Synthesis of ^<11>C-labeled uracil derivative for a PET tracer targeting thymidme phosphorylase2008
- Author(s)
  M.Takahashi, K.Seki, K.Nishijima, Y.Kuge, N.Tamaki, K.Ohkura
- Journal Title
  
  Heterocycles 76(in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] New [11C]phosgene based [11C] pyrimidines for Positron emission tomography.2008
- Author(s)
  Seki K, Nishijima K, Sanoki K, Kuge Y, Takahashi M, Akizawa H, Tamaki N, Wiebe L, Ohkura K
- Journal Title
  
  Heterocycles 77
  
  Pages: 1307-1321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016002
[Journal Article] Synthesis of ^<11>C-labeled uracil derivative for a PET tracer targeting thymidine phosphorylase2008
- Author(s)
  M. Takahashi, K. Seki, K. Nishijima, Y. Kuge, N. Tamaki, K. Ohkura
- Journal Title
  
  Heterocycles 76(in press)
- NAID
  40016208568
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] New [^<11>C]phosgene based [^<11>C] pyrimidines for Positron emission tomograpby2008
- Author(s)
  Koh-ichi Seki
- Journal Title
  
  Heterocycles 77
  
  Pages: 1307-1321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016002
[Journal Article] Synthesis of 11C-labeled uracil derivative for a PET tracer targeting thymidine phosphorylase2008
- Author(s)
  M. Takahashi, K Seki, K.Nishijima, Y. Kuge, N. Tamaki, K. Ohkura
- Journal Title
  
  Heterocycles 76(in press)
- NAID
  40016208568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] Synthesis of ^<11>C-labeled uracil derivative for a pet tracer targeting thymidine phosphorylase.2008
- Author(s)
  Takahashi M., Seki K., Nishijima K., Kuge Y., Tamaki N., Ohkura K.
- Journal Title
  
  Heterocycles 76
  
  Pages: 237-241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591457
[Journal Article] Splenic peliosis mimicking a solid tumor: findings in multimodalities.2008
- Author(s)
  Abo D, Terae S, Fukasawa Y, Seki H, Hasegawa Y, Sakuhara Y, Shimizu T, Shirato H
- Journal Title
  
  J Comput Assist Tomogr 32
  
  Pages: 890-892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016002
[Journal Article] Synthesis of 11C-labeled uracil derivative for a pet tracer targeting thymidine phosphorylase2008
- Author(s)
  Takahashi M., Seki K., Nishijima K., Kuge Y., Tamaki N., Ohkura K.
- Journal Title
  
  Hetero- cycles 76
  
  Pages: 237-241
- Data Source
  KAKENHI-PROJECT-20591457
[Journal Article] A novel and efficient synthesis of [2-11C]5-fluorouracil for prognosis of cancer chemotherapy.2007
- Author(s)
  Seki K, et. al.
- Journal Title
  
  Pharm Pharmaceut Sci 10(2)
  
  Pages: 181-185
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390332
[Journal Article] A novel and efficient synthesis of [2-11C] 5-fluorouracil for prognosis of cancer chemotherapy.2007
- Author(s)
  Seki K, et. al.
- Journal Title
  
  J Pharm Pharmaceut Sci. 10(2)
  
  Pages: 181-185
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390332
[Journal Article] A novel and efficient synthesis of [2-^<11>C]5-fluorouracil for prognosis of cancer chemotherapy2007
- Author(s)
  K. Seki, K. Nishijima, Y. Kuge, N. Tamaki, L. I. Wiebe, K. Ohkura
- Journal Title
  
  J. Pharm. Pharm. Sci 10
  
  Pages: 210-214
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] A novel and efficient synthesis of [2-^<11>C]5-fluorouracil for prognosis of cancer chemotherapy2007
- Author(s)
  K.Seki, K.Nishijima, Y.Kuge, N.Tamaki, L.I.Wiebe, K.Ohkura
- Journal Title
  
  J. Pharm. Pharm. Sci. 10
  
  Pages: 210-214
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] A novel and efficient synthesis of [2-^<11>C]5-fluorouracil for prognos is of cancer chemotherapy2007
- Author(s)
  K.Seki, K.Nishijima, Y.Kuge, N.Tamaki, L.I.Wiebe, K.Ohkura
- Journal Title
  
  J. Pharm. Pharm. Sci 10
  
  Pages: 210-214
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] A novel and efficient synthesis of [2-11C]5-fluorouracil for prognosis of cancer chemotherapy2007
- Author(s)
  K. Seki, K. NIshijima, Y. Kuge, N. Tamaki, L. Wiebe, K. Ohkura
- Journal Title
  
  J Pharm Pharmaceut Sci 10
  
  Pages: 212-216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] A new convenient method for the synthesis of [2-^<11>C]thymine utilizing [^<11>C]phosgene2007
- Author(s)
  Kazue Ohkura, Koh-ichi Seki, et al.
- Journal Title
  
  J. Pharm. Pharm. Sci. 10 (2)
  
  Pages: 181-185
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] A novel and efficient synthesis of [2-^<11>C]5-fluorouracil for prognosis of cancer chemotherapy2007
- Author(s)
  Koh-ichi Seki^<1, *>, Ken-ichi Nishijima^2, Yuji Kuge^3, Nagara Tamaki^3, Leonard I. Wiebe^4, Kazue Ohkura^<2, *>
- Journal Title
  
  J. Pharm. Pharm. Sci. 10 (2)
  
  Pages: 210-214
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] A novel and efficient synthesis of[2-^<11>C]5-fluorouracil for prognosis of cancer chemotherapy.2007
- Author(s)
  Seki, K, et. al.
- Journal Title
  
  J Pharm Pharmaceut Sci 10(2)
  
  Pages: 212-216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016002
[Journal Article] A novel and efficient synthesis of [2-11C]5-fluorouracil for prognosis of cancer chemotherapy.2007
- Author(s)
  Seki K, Nishijima K, Kuge Y, Tamaki N, Wiebe LI, Ohkura K
- Journal Title
  
  J Pharm Pharmaceut Sci. 10(2)
  
  Pages: 181-185
- Data Source
  KAKENHI-PROJECT-17390332
[Journal Article] Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenas-2 expression2006
- Author(s)
  Y. Kuge, Y. Katada, S. Shimonaka, T. Temma, H. Kimura, Y. Kiyono, C. Yokota, K. Minematsu, K. Seki, N. Tamaki, K. Ohkura, H. Saji
- Journal Title
  
  Nuclear Medicine and Biology 33
  
  Pages: 21-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibit ors as potential SPECT tracers for cyclooxygenas-2 expression2006
- Author(s)
  Y.Kuge, Y.Katada, S.Shimonaka, T.Temma, H.Kimura, Y.Kiyono, C.Yokota, K.Minematsu, K.Seki, N.Tamaki, K.Ohkura H.Saji
- Journal Title
  
  Nuclear Medicine and Biology 33
  
  Pages: 21-27
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] [^<11>C]ホスゲンを用いた核酸系PET薬剤の合成法の開発2006
- Author(s)
  関興一, 他
- Journal Title
  
  放射線生物研究 41・4
  
  Pages: 387-398
- NAID
  40015265465
- Data Source
  KAKENHI-PROJECT-17016002
[Journal Article] A new convenient method for the synthesis of [2-^<11>C]thymine utilizing [^<11>C]phosgene2006
- Author(s)
  K.Ohkura, K.Nishijima, K.Sanoki, Y.Kuge, N.Tamaki, Koh-ichi Seki
- Journal Title
  
  Tetrahedron Lett. 2006
  
  Pages: 5321-5323
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] [^<11>C]ホスゲンを用いた核酸系PET薬剤の合成法の開発2006
- Author(s)
  関興一, 西嶋剣一, 大倉一枝
- Journal Title
  
  放射線生物研究、 41・4
  
  Pages: 387-398
- NAID
  40015265465
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] A new convenient method for the synthesis of [2-^<11>C]thymineuti lizing [^<11>C]phosgene2006
- Author(s)
  K.Ohkura, K.Nishijima, K.Sanoki, Y.Kuge, N.Tamaki, K.Seki
- Journal Title
  
  Tetrahedron Lett 47
  
  Pages: 5321-5323
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] Photochemical synthesis of polycyclic pyrimidines through the acid catalyzed cycloaddition of 6-chloro-1-methyluracil to methyl substituted bezenes.2006
- Author(s)
  Ohkura K, Yamaguchi T, Nishijima K, Kuge Y, Seki K
- Journal Title
  
  Heterocycles. 70
  
  Pages: 501-508
- Data Source
  KAKENHI-PROJECT-17390332
[Journal Article] A new convenient method for the synthesis of [2-11C]thymine utilizing [11C]phosgene.2006
- Author(s)
  Ohkura K, Nishijima K, Sanoki K, Kuge Y, Tamaki N, Seki K
- Journal Title
  
  Tetrahedron Letters. 47
  
  Pages: 5321-5323
- Data Source
  KAKENHI-PROJECT-17390332
[Journal Article] A new convenient method for the synthesis of [2-^<11>C]thymine utilizing [^<11>C]phosgene2006
- Author(s)
  Kazue Ohkura, Koh-ichi Seki, et al.
- Journal Title
  
  Tetrahedron Lett. 2006
  
  Pages: 5321-5323
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] [^<11>C]ホスゲンを用いた核酸系PET薬剤の合成法の開発2006
- Author(s)
  関興一, 西嶋剣一, 大倉一枝
- Journal Title
  
  放射線生物研究 41・4
  
  Pages: 387-398
- NAID
  40015265465
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Synthesis of N1, N3-free pyrimidine bridged polycyclic compounds via photo-DIELS- ALDER reaction of N,N-diacetyl 5-fluorouracil with naphthalenes2006
- Author(s)
  Kazue Ohkura, Koh-ichi Seki, et al.
- Journal Title
  
  Heterocycles 69
  
  Pages: 515-520
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenas-2 expression2006
- Author(s)
  Yuji Kuge, Koh-ichi Seki, et al.
- Journal Title
  
  Nuclear Medicine and Biology 33,1
  
  Pages: 21-27
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenas-2 expression2006
- Author(s)
  Yuji Kuge, Yumiko Katada, Sayaka Shimonaka, Takashi Temma, Hiroyuki Kimura, Yasushi Kiyono, Chiaki Yokota, Kazuo Minematsu4, Koh-ichi Seki5, Nagara Tamaki6, Kazue Ohkura7, Hideo Saji
- Journal Title
  
  Nuclear Medicine and Biology 3 (1)
  
  Pages: 21-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Synthesis of N1,N3-free pyrimidine bridged polycyclic compounds via photo-DIELS-ALDER reaction of N, N-diacetyl 5-fluorouracil with naphthalenes, Heterocycles2006
- Author(s)
  Kazue Ohkura, Tetsuya Ishihara, James M. Diakur, Koh-ichi Seki
- Journal Title
  
  Heterocycles 69
  
  Pages: 515-520
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Synthesis of N1, N3-free pyrimidine bridged polycyclic compounds via photo-DIELS- ALDER reaction of N,N-diacetyl 5-fluorouracil with naphthalenes2006
- Author(s)
  K.Ohkura, T.Ishihara, J.M.Diakur, K.Seki
- Journal Title
  
  Heterocycles 69
  
  Pages: 515-520
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenas-2 expression2006
- Author(s)
  Y.Kuge, Y.Katada, S.Shimonaka, T.Temma, H.Kimura, Y.Kiyono, C.Yokota, K.Minematsu, Koh-ichi Seki, N.Tamaki, K.Ohkur, H.Saji
- Journal Title
  
  Nuclear Medicine and Biology 3
  
  Pages: 21-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] A new convenient method for the synthesis of[2-^<11>C]thymine utilizing[^<11>C]phosgene2006
- Author(s)
  K. Ohkura, K. Nishijima, K. Sanoki, Y. Kuge, N. Tamaki, K. Seki
- Journal Title
  
  Tetrahedron Letters 47
  
  Pages: 5321-5323
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Journal Article] A new convenient method for the synthesis of [2-11C]thymine utilizing [11C]phosgene2006
- Author(s)
  Kazue Ohkura, Ken-ichi Nishijima, Kimihito Sanoki, Yuji Kuge, Nagara Tamaki, Koh-ichi Seki
- Journal Title
  
  Tetrahedron Lett.
  
  Pages: 5321-5323
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] (2S)-2-[1-(2,4-Difluoro-5-iodophenyl)-2-deoxy-β-D-ribofuranos-5-yl]-8-methyl-4H-1,3,2,benzodioxaphosphole 2-oxide.2004
- Author(s)
  K.Ohkura, W.Y.Sun, K.Seki, E.E.Knaus, L.I.Wiebe
- Journal Title
  
  Acta Cryst., C 60
  
  Pages: 789-791
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591297
[Journal Article] (2S)-2-[1-(2,4-Difluoro-5-iodophenyl)-2-deoxy-[3-D-ribofuranos-5-yl]-8-methyl-4H-1,3,2- benzodioxaphosphole-2-oxide2004
- Author(s)
  K.Ohkura, W.Y.Sun, K.Seki, E.E.Knaus, L.I.Wiebe
- Journal Title
  
  Acta Cryst C60
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591297
[Journal Article] Preparation and Pre-clinical Evaluation of High Specific Activity S-(-)[^<11>C]CGP-12177, a Radioligand for β-Adrenoreceptors2004
- Author(s)
  K.Nishijima, Y.Kuge, N.Motoki, K.Seki, K.Ohkura, E.Tsukamoto, K.Morita, N.Tamaki
- Journal Title
  
  Nuclear Medicine Communications 25
  
  Pages: 845-849
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] (2S)-2-[1-(2,4-Difluoro-5-iodophenyl)-2-deoxy-β-D-ribofuranos-5-yl]-8-methyl-4H-1,3,2-benzodioxaphosphole 2-oxide.2004
- Author(s)
  K.Ohkura, W.Y.Sun, K.Seki, E.E.Knaus, L.I.Wiebe
- Journal Title
  
  Acta Cryst., C 60
  
  Pages: 789-791
- Data Source
  KAKENHI-PROJECT-15591297
[Journal Article] (2S)-2[1-(2,4-Difluoro-5-iodphenyl)-2-deoxy-β-D-ribofuranos-5-yloxy]-8-methyl-4H-1,3,2-benzodioxaphosphole 2-oxide2004
- Author(s)
  K.Ohkura, W.Y.Sun, K.Seki, E.E.Knaus, L.I.Wiebe
- Journal Title
  
  Acta Crystallographica, Section C : Crystal Structure Communications C60
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Synthesis and Antiviral Activity of Novel Fluorinated 2',3'-Dideoxynucleoside2004
- Author(s)
  P.Kumar, K.Ohkura, J.Balzarini, E.De Clercq, K.Seki, L.I.Wiebe
- Journal Title
  
  Nucleosides, Nucleotides & Nucleic Acids 23
  
  Pages: 7-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591297
[Journal Article] (2S)-2[1-(2,4-Difluoro-5-iodpheny1)-2-deoxy-□-D-ribofurano s-5-yloxy]-8-methyl-4H-1,3,2-benzodioxaphosphole 2-oxide2004
- Author(s)
  Kazue Ohkura, Wei Yan Sun, Koh-ichi Seki, Edward E. Knaus, Leonard I. Wiebe
- Journal Title
  
  Acta Crystallographica, Section C : Crystal Structure Communications C60 (11)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Preparation and Pre-clinical Evaluation of High Specific Activity S-(-)[^<11>C]CGP-12177, a Radioligand for □-Adrenoreceptors2004
- Author(s)
  Ken-ichi Nishijima, Yuji Kuge, Noriko Motoki, Koh-ichi Seki, Kazue Ohkura, Eriko Tsukamoto, Kohich Morita, Nagara Tamaki
- Journal Title
  
  Nuclear Medicine Communications 25 (8)
  
  Pages: 845849-845849
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591179
[Journal Article] Synthesis and Antiviral Activity of Novel Fluorinated 2',3'-Dideoxy-nucleoside2004
- Author(s)
  P.Kumar, K.Ohkura, J.Balzarini, E.De Clercq, K.Seki, L.I.Wiebe
- Journal Title
  
  Nucleosides, Nucleotides & Nucleic Acids 23
  
  Pages: 7-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591297
[Journal Article] Synthesis of 1-β-D-(5-Deoxy-5-iodoarabinofuranosyl)-2-nitroimidazole (β-IAZA): A Novel Marker of Tissue Hypoxia2003
- Author(s)
  P.Kumar, K.Ohkura, D.Beiki, L.I.Wiebe, K.Seki
- Journal Title
  
  Chem.Pharm.Bull. 51
  
  Pages: 399-403
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591297
[Journal Article] Synthesis of 1-β-D-(5-Deoxy-5-iodoaribinofuranosyl)-2-nitro-imidazole). (β-IAZA) : A Novel Marker of Tissue Hypoxoa2003
- Author(s)
  P.Kumar, K.Ohkura, D.Beiki, L.I.Wiebe, K.Seki
- Journal Title
  
  Chem.Pharm.Bull. 51
  
  Pages: 399-403
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591297
[Patent] ウラシル化合物又はその塩、これらを有効成分として含有するイメージング剤、およびこれらを有効成分として含有する腫瘍診断をするためのイメージング剤2007
- Inventor(s)
  大倉一枝、関興一、西嶋剣一、高橋正幸、久下裕司、玉木長良、趙松吉
- Industrial Property Rights Holder
  大倉一枝、関興一、西嶋剣一、高橋正幸、久下裕司、玉木長良、趙松吉
- Industrial Property Number
  2007-229002
- Filing Date
  2007-09-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390332
[Patent] ウラシル化合物又はその塩、これらを有効成分として含有するイメージング剤、およびこれらを有効成分として含有する腫瘍を診断するためのイメ-ジング剤2007
- Inventor(s)
  大倉一枝, 関興一, 西嶋剣一, 高橋正幸, 久下裕司, 玉木長良, 趙松吉
- Industrial Property Rights Holder
  大鵬薬品工業株式会社学校法人東日本学園・北海道医療大学国立大学法人北海道大学
- Industrial Property Number
  2007-229002
- Filing Date
  2007-09-04
- Data Source
  KAKENHI-PROJECT-17591288
[Patent] ウラシル化合物又はその塩、これらを有効成分として含有するイメージング剤、およびこれらを有効成分として含有する腫瘍を診断するためのイメージング剤2007
- Inventor(s)
  大倉一枝, 関興一, 西嶋剣一, 高橋正幸, 久下裕司, 玉木長良, 趙松吉
- Industrial Property Rights Holder
  大鵬薬品工業株式会社学校法人東日本学園、北海道医療大学国立大学法人北海道大学
- Industrial Property Number
  2007-229002
- Filing Date
  2007-09-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Presentation] [^<11>C] phosgeneを用いるoxoimidazolidinylmethyluracilの合成とがんイメージングプローブへの応用2010
- Author(s)
  関興一・西嶋剣一・高橋正幸・趙松吉・向田理恵・秋澤宏行・久下裕司・玉木長良・大倉一枝
- Organizer
  日本化学会第90春季年会
- Place of Presentation
  大阪(近畿大学)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20591457
[Presentation] A novel radiolabeled probe for molecular imaging of thymidine phosphorylase : Suppressed accumulation into tumor cells by target gene knockdown.2010
- Author(s)
  Li H, Zhao S, Jin Y, Nishijima K, Akizawa H, Ohkura K, Seki K, Tamaki N, Kuge Y
- Organizer
  2010 World Molecular Imaging Congress
- Place of Presentation
  Kyoto, Japan.
- Data Source
  KAKENHI-PROJECT-20390320
[Presentation] [11C]phosgeneを用いるoxoimidazolidinylmethyluracilの合成とがんイメージングプローブへの応用。2010
- Author(s)
  関興一, 他
- Organizer
  日本化学会第90春季年会
- Place of Presentation
  大阪(近畿大学本部キャンパス)
- Data Source
  KAKENHI-PROJECT-20390320
[Presentation] [11C]phosgene を用いるoxo-imidazolidinylmethyluracil の合成とがんイメージングプローブへの応用2010
- Author(s)
  関興一・西嶋剣一・高橋正幸・趙松吉・向田理恵・秋澤宏行・久下裕司・玉木長良・大倉一枝
- Organizer
  日本化学会第90春季年会
- Place of Presentation
  大阪
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20591457
[Presentation] Synthesis of a Potential SPECT Tracer for Angiogenic Enzyme Expression2008
- Author(s)
  関興一
- Organizer
  World Molecular Imaging Congress
- Place of Presentation
  Acropolis Convention Center, Nice, France
- Data Source
  KAKENHI-PROJECT-17016002
[Presentation] Ohkura Synthesis of a potential SPECT radiopharmaceutical targeting thymidine phosophorylase2008
- Author(s)
  M. Takahashi, S. Zhao, K. Nishijima, Y. akuge, K. Seki, K
- Organizer
  The 128th Annual meeting of Pharma-ceutical Society of Japan
- Place of Presentation
  Yokohama
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Presentation] チミジンボスホリラーゼ標的SPECT薬剤の合成2008
- Author(s)
  高橋正幸、趙松吉、西嶋剣一、久下裕司、関興一、大倉一枝
- Organizer
  日本薬学会第128年会(横浜)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Presentation] Synthesis of a Potential SPECT Tracer for Angiogenic Enzyme Expression Graduate School of Medicine.2008
- Author(s)
  Seki K, Takahashi M, Zhao S, Nishijima K, Kuge Y, Tamaki N, Ohkura K
- Organizer
  2008 World Molecular Imaging Congress
- Place of Presentation
  Nice.
- Data Source
  KAKENHI-PROJECT-20390320
[Presentation] Synthesis of a Potential SPECT Tracer for Angiogenic Enzyme Expression2008
- Author(s)
  Seki K, et.al.
- Organizer
  2008 World Molecular Imaging Congress
- Place of Presentation
  Nice, The Acropolis Convention Center
- Data Source
  KAKENHI-PROJECT-20390320
[Presentation] 薬学と医学を放射能でつないで2008
- Author(s)
  関興一
- Organizer
  バイオメディカル分析化学シンポジウム-生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  札幌、札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-17016002
[Presentation] Development of a novel and general synthesis of [2-^<11>C]pyrimidine2007
- Author(s)
  K. Seki, K. Nishijima, K. Sanoki, Y. Kuge, N. Tamaki, K. Ohkura
- Organizer
  JCSRC 2007 Seventh Japan-China Joint Seminar on Radiopharmaceutical Chemistry
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-17591288
[Presentation] Development of a novel and general synthesis of [2-^<11>C]pyrimidine2007
- Author(s)
  K.Seki, K.Nishijima, K.Sanoki, Y.Kuge, N.Tamaki, K.Ohkura
- Organizer
  JCSRC 2007 Seventh Japan China Joint Seminar on Radiopharmaceutical Chemistry
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Presentation] 18F-FLT but not 18F-FDG can early and dose-dependently detect antiproliferative responses of human tumor xenograft to epidermal growth factor receptor targeting with a tyrosine kinase inhibitor, gefitinib2007
- Author(s)
  Zhao S, Kuge Y, Zhao Y, Takei T, Kanegae K. Inubushi M, Shiga T, Seki K, Tamaki N
- Organizer
  The 54th Annual Meeting, Society of Nuclear Medicine
- Place of Presentation
  Washington DC ワシントン条約センター
- Year and Date
  2007-06-04
- Data Source
  KAKENHI-PROJECT-17016002
[Presentation] 細胞増殖能評価、腫瘍一肉芽腫の鑑別診断における11C-methionineと18F-FDGの比較2007
- Author(s)
  趙松吉, 久下裕司, 趙芫, 竹井俊樹, 加藤誠一, 鐘ヶ江香久子, 岡本祥三, 加藤千恵次, 関興一, 玉木長良
- Organizer
  第47回日本核医学会学術総会
- Place of Presentation
  仙台,仙台国際センター
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-17016002
[Presentation] 3H-FLTによる癌の分子標的療法の早期評価:胆がんマウスにおける投与量依存性の検討2007
- Author(s)
  趙松吉, 久下裕司, 趙芫, 竹井俊樹, 鐘ヶ江香久子, 犬伏正幸, 志賀哲, 加藤千恵次, 関興一, 玉木長良
- Organizer
  第47回日本核医学会学術総会
- Place of Presentation
  仙台,仙台国際センター
- Year and Date
  2007-11-05
- Data Source
  KAKENHI-PROJECT-17016002
[Presentation] Development of a novel and general synthesis of 2-^<11>C]pyrimidine2007
- Author(s)
  K. SeKi, K. Nishijima, K. SanoKi, Y. Kuge, N. Iamaki, K. Ohkura
- Organizer
  JCSRC 2007 seventh Japan-China Joint Seminar on Radiopharmaceutical Chemistry
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591288
[Presentation] 細胞の増殖脳の評価及び腫瘍と肉芽腫の鑑別診断における11C-メチオニンの有用性:18F-FDGとの比較2007
- Author(s)
  趙松吉, 久下裕司, 小華和柾志, 趙芫, 鐘ヶ江香久子, 関興一, 玉木長良
- Organizer
  第2回日本分子イメージング学会総会・学術集会
- Place of Presentation
  福井福井フェニックスプラザ
- Data Source
  KAKENHI-PROJECT-17016002
[Presentation] Usefulness of^<11>C-methionine in evaluating cellular proliferation and differential diagnosis of tumor and granuloma:An experimental study in comparison with 18F-FDG2007
- Author(s)
  Zhao S, Kuge Y, Kohanawa M, Zhao Y, Kanegae K, Seki K, Tamaki N
- Organizer
  The 54th Annual Meeting, Society of Nuclear Medicine
- Place of Presentation
  Washington DC ワシントン条約センター
- Year and Date
  2007-06-03
- Data Source
  KAKENHI-PROJECT-17016002

1. TAMAKI Nagara (30171888)

# of Collaborated Projects: 8 results

# of Collaborated Products: 25 results
2. KUGE Yuji (70321958)

# of Collaborated Projects: 7 results

# of Collaborated Products: 12 results
3. OHKURA Kazue (60094827)

# of Collaborated Projects: 5 results

# of Collaborated Products: 46 results
4. SAJI Hideo (40115853)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. KIYONO Yasushi (50305603)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. YOKOTA Chiaki (80300979)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. ONIMARU Rikiya (80374461)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. NISHIJIMA Kenichi (60364254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
9. 飯田靖彦 (60252425)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. SHIRATO Hiroki (20187537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. KANEKO Junichi (90333624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NISHIYAMA Syusuke (30333628)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KATOH Chietsugu (10292012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. AOYAMA Hidefumi (80360915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NISHIOKA Takeshi (80271659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MORITA Koichi (20210172)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. DATE Hiroyuki (10197600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TAKADA Eiji (00270885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. TOMIOKA Satoshi (40237110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KUDO Kohsude (10374232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ONODERA Yuya (10272064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KAMISHIMA Tamotsu (10399868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. SHIMIZU Shinichi (50463724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
24. SAKUHARA Yusuke (40374459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
25. OYAMA Noriko (70463742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. ABO Daisuke (30399844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
27. TAGUCHI Hiroshi (90374454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. ZHAO Songji (80374239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
29. AKIZAWA Hiromichi (90311795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
30. UEDA Masashi (40381967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 河嶋秀和 (70359438)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 向高弘 (30284706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SEKI Koh-ichi 関 興一

関 與一 セキ コウイチ

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Fundamental Studies on the Development of New Diagnostic Radio Tracers Targeting Angiogenesis FactorsPrincipal Investigator

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[Journal Article] In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging.2010

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[Journal Article] New [^<11>C] phosgene based synthesis of [^<11>C] pyrimidines for positron emission tomography2009

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[Journal Article] New [11C] phosgene based synthesis of [11C]- pyrimidines for positron emission tomography2009

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[Journal Article] Splenic peliosis mimicking a solid tumor : findings in multimodalities2008

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[Journal Article] Synthesis of ^<11>C-labeled uracil derivative for a PET tracer targeting thymidme phosphorylase2008

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[Journal Article] New [11C]phosgene based [11C] pyrimidines for Positron emission tomography.2008

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SEKI Koh-ichi 関興一

関與一セキコウイチ