KOBAYASHI Hiroyuki 小林広幸

… Alternative Names

Researcher Number	60195807
Other IDs
Affiliation (Current)	2020: 東海大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2020: 東海大学, 医学部, 教授 2007 – 2017: 東海大学, 医学部, 教授 2003: 東海大, 医学部, 助教授 1997 – 2001: 東海大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Medical pharmacy / Applied pharmacology / General pharmacology Except Principal Investigator Neurochemistry/Neuropharmacology / General pharmacology / Evolutionary biology / Circulatory organs internal medicine / Kidney internal medicine / General pharmacology / Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 薬剤反応性 / がん / 国際情報交換　米国 / RT-PCR / 癌 / 酵素 / シグナル伝達 / 核酸 / 薬物耐性 / ニューオピオイド受容体 … More Except Principal Investigator 神経調節性失神 / RT-PCR / in situ hybridization / モルヒネ / ペチジン / コカイン / in vivo microdialysis / ドパミン / アンチセンスオリゴDNA / 線条体 / 輸送体 / D-セリン / セリンラセマーゼ / 統合失調症 / D-アミノ酸オキシダーゼ / RNA干渉 / ノックアウトマウス / 分子系統樹 / 人為淘汰 / 家畜化 / ドーパミン受容体 / DRD2 / DRD3 / DRD4 / ニワトリ / ドーパミン / アドレナリン / 自律神経 / アドレナリンレセプター / アドレナリン受容体 / 遺伝子多型性 / 腹膜透析 / 腹膜保護 / ピリドキサミン / 内服薬 / カルボニル・ストレス / carbonyl / 半減期 / ミューオピオイド受容体 / Gタンパク質 / アンチセンスオリゴヌクレオチド / ウェスタンブロット / in situ hvbridization / オピオイドペプチド / モルヒネ鎮痛 / G_<iα1> / G_<iα2> / G_<iα3> / G_<0α> / G_<sα> / mu-opioid receptor / G protein / antisense oligodeoxynucleotides / western blot / opioid peptides / morphine-induced analgesia / アデニル酸シクラーゼ / ホルター心電図 / カテコラミン受容体遺伝子 / カフェイン Less

Diagnosis and therapeutic effect of neurally mediated syncope (NMS) using fluctuation of adenylate cyclase activityOngoing
- Principal Investigator
  
  小見山智義
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Tokai University
Candidate biomarkers for predicting drug response in cancer treatmentPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokai University
Examination of pharmacokinetics and pharmacodynamics of pyridoxamine as a protective agent of peritoneal membrane
- Principal Investigator
  
  KAKUTA Takatoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokai University
Targeted therapy for anti-cancer drug resistance: Basic researchPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Hiroyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokai University
The Role of Adrenaline in Neurally Mediated Syncope
- Principal Investigator
  
  SATO Kyoko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Women's Medical University
  Tokai University
Evolutionary Origin and Genetic Differentiation of Dopamine Receptor D2, D3 and D4 Genes of Japanese Domesticated Chickens
- Principal Investigator
  
  KOMIYAMA Tomoyoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Evolutionary biology
- Research Institution
  Tokai University
Targeted therapy for anti-cancer drug resistance mediated by several kinase pathways activationPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Hiroyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokai University
Functional analysis of D-serine-metabolizing enzymes using RNA interference : Application to treatment of schizophrenia
- Principal Investigator
  
  HASHIMOTO Atsushi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Tokai University
ランダム化RNAiライブラリーを用いた抗癌剤感受性遺伝子の探索Principal Investigator
- Principal Investigator
  
  小林広幸
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tokai University
Differential blockade of opioid analgesia by gene-specific therapeutics directed against various G protein α subnitsPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Hiroyuki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Tokai University
アンチセンスオリゴDNAを用いた脳内特定タンパク質の発現阻止に関する研究
- Principal Investigator
  
  OKA Tetsuo
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokai University
Elucidation of cellular mechanism of mu-opioid receptor agonist-induced analgesia by employing antisense oligodeoxynucleotide
- Principal Investigator
  
  OKA Tetsuo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Tokai University

All 2017 2016 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Lymphatic invasion is a significant indicator of poor patient prognosis in lung squamous cell carcinoma2017
- Author(s)
  Masuda R, Kijima H, Nito M, Wada A, Matsuzaki T, Ikoma Y, Nakazato K, Masuda D, Tanaka M, Kobayashi H, Inokuchi S, Iwazaki M.
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: 15 Pages: 2067-2073
- DOI
  10.3892/mmr.2017.6256
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15011, KAKENHI-PROJECT-15K08109
[Journal Article] Analysis to Estimate Genetic Variations in the Idarubicin-Resistant Derivative MOLT-3.2016
- Author(s)
  Komiyama T, Ogura J, Hirokawa T, Kamikuchi H, Asai S, Miyachi H, Kobayashi H.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 18 Pages: 1-13
- DOI
  10.3390/ijms18010012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460657, KAKENHI-PROJECT-15K08109
[Journal Article] Oral administration of pyridoxamine lower peritoneal carbonyl stress in uremic rats2016
- Author(s)
  Mori Y, Kakuta T, Miyakogawa T, Takekoshi S, Yuzawa H, Kobayashi H, Kawakami A, van Ypersele de Strihou C, Fukagawa M
- Journal Title
  
  Therapeutic Apheresis and Dialysis
  
  Volume: 20
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461256
[Journal Article] Possible Association of Human Adrenoceptors Polymorphism in Neurally Mediated Syncope2013
- Author(s)
  Kyoko Sato, Tomoyoshi Komiyama, Hiroyuki Kobayashi, Kuniaki Otsuka
- Journal Title
  
  The Autonomic Nervous System
  
  Volume: (in press)
- NAID
  10031183955
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590797
[Journal Article] Cysteinyl leukotriene receptor antagonists inhibit tumor metastasis by inhibiting capillary permeability2010
- Author(s)
  Nozaki M, Yoshikawa M, Ishitani K, Kobayashi H, Houkin K, Imai K, Ito Y, Muraki T
- Journal Title
  
  Keio Journal of Medicine
  
  Volume: 59 Pages: 10-18
- NAID
  10026203480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590180
[Journal Article] Midazolam attenuates the antinociception induced by D-serine or morphine at the supraspinal level in rats.2008
- Author(s)
  Ito K., Yoshikawa M., Maeda M., Jin X.L., Takahashi S., Matsuda M., Tamaki R., Kobayashi H., Suzuki T., Hashimoto A.
- Journal Title
  
  morphine at the supraspinal level in rats. 586
  
  Pages: 139-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590258
[Journal Article] Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase2008
- Author(s)
  N., Tsukamoto, H., Kawaguchi M., Kobayashi M., Oka, T., Hashimoto, A.
- Journal Title
  
  J. Pharmacol. Sci. 107
  
  Pages: 270-276
- NAID
  10024321297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590258
[Journal Article] Mice lacking D-amino acid oxidase activity exhibit marked reduction of methamphetamine -induced stereotypy.2008
- Author(s)
  Hashimoto A., Konno R., Yano H., Yoshikawa M., Tamaki R., Matsumoto H., Kobayashi H.
- Journal Title
  
  Eur. J. Pharmacol. 586
  
  Pages: 221-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590258
[Journal Article] Activation of supraspinal NMDA receptors by both D-serine alone or in combination with morphine leads to the potentiation of antinociception in tail-flick2007
- Author(s)
  Yoshikawa M., Ito K., Maeda M., Akahori K., Takahashi S., Jin X.L., Matsuda M., Suzuki T., Oka T., Kobayashi H., Hashimoto A.
- Journal Title
  
  Eur. J. Pharmacol. 565
  
  Pages: 89-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590258
[Journal Article] The serine racemase mRNA is predominantly expressed in rat brain neurons2007
- Author(s)
  Yoshikawa M., Takayasu N., Hashimoto A., Sato Y., Tamaki R., Tsukamoto H., Kobayashi H., Noda S.
- Journal Title
  
  Arch. Histol. Cytol. 70
  
  Pages: 127-134
- NAID
  10019551068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590258
[Journal Article] Effects of MK-801 on the expression of serine racemase and D-amino acid oxidase mRNAs and on the D-serine levels in rat brain.2007
- Author(s)
  Hashimoto A., Yoshikawa M., Andoh H., Yano H., Matsumoto H., Kawaguchi M., Oka T., Kobayashi H.
- Journal Title
  
  Eur. J. Pharmacol 555
  
  Pages: 17-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590258
[Presentation] The Application for Genetic Evaluation of Human Adrenoceptors Polymorphism in Neurally Mediated Syncope2012
- Author(s)
  Kyoko Sato, Tomoyoshi Komiyama, Hiroyuki Kobayashi, Kuniaki Otsuka
- Organizer
  The 35th Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Fukuoka
- Year and Date
  2012-12-12
- Data Source
  KAKENHI-PROJECT-22590797
[Presentation] ヒトアドレナリンレセプター遺伝子多型性と起立性調節障害との関連性について2012
- Author(s)
  佐藤恭子, 小見山智義, 西村芳子,柴田興一, 小林広幸, 大塚邦明
- Organizer
  第65回日本自律神経学会総会
- Place of Presentation
  東京
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-22590797
[Presentation] 日本鶏を用いたドーパミン受容体D2, D3, D4の遺伝的分化に関する解析2011
- Author(s)
  小見山智義、岩間久和、舘野義男、小林広幸、五條堀孝
- Organizer
  日本進化学会第13回大会
- Place of Presentation
  京都大学(京都市)
- Data Source
  KAKENHI-PROJECT-21570241
[Presentation] Evolutionary Study of Japanese Domesticated Chickens through Dopamine Receptor2011
- Author(s)
  T. Komiyama, H. Iwama, Y. Tateno, H. Kobayashi, T. Gojobori
- Organizer
  SMBE2011京都
- Place of Presentation
  京都大学(京都市)
- Data Source
  KAKENHI-PROJECT-21570241
[Presentation] Possible Association of Human Adrenoceptors Polymorphism in Neurally Mediated Syncope2011
- Author(s)
  Kyoko Sato, Tomoyoshi Komiyama, Hiroshi Kamiguchi, Ayako Mikami, Hiroyuki Kobayashi, Kuniaki Otsuka
- Organizer
  The 34th Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Yokohama
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22590797
[Presentation] The Evolutional Relationship between the Domestication of Fighting Roosters and the repeat variation of Dopamine receptor D42010
- Author(s)
  Tomoyoshi. Komiyama, H.Iwama, Y.Nakamura, K.Sato, H.Kobayashi, Y.Tateno, K.Ikeo, H.Inoko, T.Gojobori
- Organizer
  Molecular Biology and Evolution (SMBE)
- Place of Presentation
  Lyon France
- Data Source
  KAKENHI-PROJECT-21570241
[Presentation] The Evolutional Relationship between the Domestication of Fighting Roosters and the repeat variation of Dopamine receptor D42010
- Author(s)
  T. Komiyama, H. Iwama, Y. Nakamura, K. Sato, H. Kobayashi, Y. Tateno, H. Inoko, K. Ikeo, T. Gojobori
- Organizer
  Annual Meeting of the Society for Molecular Biology and Evolution(SMBE 2010) Lyon France
- Place of Presentation
  Lyon Convention Center
- Data Source
  KAKENHI-PROJECT-21570241
[Presentation] ドーパミンレセプターDRD4遺伝子の多型と進化にみる闘争心の起源2010
- Author(s)
  小見山智義, 岩間久和, 中村洋路, 佐藤恭子, 池尾一穂, 小林広幸, 猪子英俊, 五條堀孝
- Organizer
  日本遺伝学会第82回札幌大会
- Place of Presentation
  北海道大学(札幌市)
- Data Source
  KAKENHI-PROJECT-21570241
[Presentation] ドーパミンレセプターDRD4遺伝子の多型と進化にみる闘争心の起源2010
- Author(s)
  小見山智義、岩間久和、中村洋路、佐藤恭子、池尾一穂、小林広幸、猪子英俊、五條堀孝
- Organizer
  日本遺伝学会第82回札幌大会
- Place of Presentation
  北海道大学(北海道)
- Data Source
  KAKENHI-PROJECT-21570241
[Presentation] ドーパミンレセプター遺伝子の多型と闘鶏用シャモにおけるドメスティーケーション成立過程との関係2009
- Author(s)
  小見山智義, 岩間久和, 中村洋路, 池尾一穂, 小林広幸, 猪子英俊, 五條堀孝
- Organizer
  日本進化学会第11回札幌大会
- Place of Presentation
  北海道大学(札幌市)
- Data Source
  KAKENHI-PROJECT-21570241
[Presentation] ケタミン長期投与によるD-セリン代謝酵素遺伝子発現の変化2009
- Author(s)
  渡邊真理子、吉川正信、竹山和秀、村田智彦、金幸禄、小林智美、橋本篤司、小林広幸、鈴木利保
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590258
[Presentation] D-セリン関連タンパク質のmRNAは唾液腺において発現する2008
- Author(s)
  吉川正信、四宮敬史、小林智美、赤堀一仁、橋本篤司、小林広幸、川口充
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590258
[Presentation] セリンラセマーゼMrnaは主に神経細胞に発現する2007
- Author(s)
  吉川正信、高安直子、野田節子、佐藤雄一、小林広幸、橋本篤司
- Organizer
  第50回日本神経化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590258

1. YOSHIKAWA Masanobu (90276791)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
2. KOMIYAMA Tomoyoshi (60439685)

# of Collaborated Projects: 5 results

# of Collaborated Products: 12 results
3. HASHIMOTO Atsushi (80271592)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
4. YU Shyr

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
5. OKA Tetsuo (40055976)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. HANDE Kenneth R.

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. GOJOBORI Takashi (50162136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. IWAMA Hisakazu (20398035)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
9. NAKAMURA Youji (90463182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. TANAKA Tuyoshi (70414919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SATO Kyoko (80335942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. MIKAMI Ayako (50564697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. ISOZAKI Mitsuhiro (90424332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KAKUTA Takatoshi (50276854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. FUKAGAWA Masafumi (00211516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 吉岡公一郎 (30246087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 永田栄一郎 (00255457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. BOKU Shikei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. MACE Rothenberg L.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 浅井さとみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 宮地勇人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 鬼島宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOBAYASHI Hiroyuki 小林 広幸

小林 広幸 コバヤシ ヒロユキ

Research Projects

Research Products

Co-Researchers

Diagnosis and therapeutic effect of neurally mediated syncope (NMS) using fluctuation of adenylate cyclase activityOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Candidate biomarkers for predicting drug response in cancer treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Examination of pharmacokinetics and pharmacodynamics of pyridoxamine as a protective agent of peritoneal membrane

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Targeted therapy for anti-cancer drug resistance: Basic researchPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Role of Adrenaline in Neurally Mediated Syncope

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evolutionary Origin and Genetic Differentiation of Dopamine Receptor D2, D3 and D4 Genes of Japanese Domesticated Chickens

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Targeted therapy for anti-cancer drug resistance mediated by several kinase pathways activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of D-serine-metabolizing enzymes using RNA interference : Application to treatment of schizophrenia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ランダム化RNAiライブラリーを用いた抗癌剤感受性遺伝子の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Differential blockade of opioid analgesia by gene-specific therapeutics directed against various G protein α subnitsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アンチセンスオリゴDNAを用いた脳内特定タンパク質の発現阻止に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of cellular mechanism of mu-opioid receptor agonist-induced analgesia by employing antisense oligodeoxynucleotide

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Lymphatic invasion is a significant indicator of poor patient prognosis in lung squamous cell carcinoma2017

Author(s)

Journal Title

KOBAYASHI Hiroyuki 小林広幸

小林広幸コバヤシヒロユキ