OZAKI Yukio 尾崎幸生

Researcher Number	60204187
Other IDs
External Links
Affiliation (Current)	2025: 長崎大学, 医歯薬学総合研究科(歯学系), 助教
Affiliation (based on the past Project Information) *help	2018 – 2024: 長崎大学, 医歯薬学総合研究科(歯学系), 助教 2011 – 2013: 長崎大学, 医歯(薬)学総合研究科, 助教 1999: 長崎大学, 歯学部, 助手 1998: 長崎大学, 医学部・附属病院, 助手 1998: 長崎大学, 歯学部・附属病院, 助手 1996 – 1998: 長崎大学, 歯学部附属病院, 助手 1993 – 1995: 長崎大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator Conservative dentistry / Basic Section 57030:Conservative dentistry-related / Periodontal dentistry / Functional basic dentistry Except Principal Investigator Basic Section 57030:Conservative dentistry-related / Functional basic dentistry / Conservative dentistry
Keywords	Principal Investigator 免疫組織化学 / ニフェジピン / 歯肉増殖症 / メダラシン / 歯周炎モデル / 人工歯石 / 上皮バリア / ピロトーシス / NLRP3インフラマソーム / IL-4 … More / IFN-γ / TLR / Th2 / 骨吸収 / Th 17 / IL-23 / IL-10 / Th1 / TNF-α / TLR4 / TLR2 / IL-17 / Th17 / 抗増殖細胞核抗原 / 線維芽細胞増殖因子-2 / ラット / セリンプロテアーゼ … More Except Principal Investigator インフラマソーム / 全身疾患 / 歯周病 / シクロデキストリン / 実験的根尖性歯周炎 / βーシクロデキストリン / コレステロール結晶 / enzyme immunoassay / proteinase inhibitor / immunohistochemistry / gingival overgrowth / periodontal disease / cathepsin G / medullasin / プロテアーゼインヒビター / 好中球 / 歯肉増殖症 / 酵素免疫測定 / プロテイナーゼインヒビター / 免疫組織学 / 歯肉増殖 / 歯周疾患 / カテプシンG / メダラシン / SCID mouse / Nude mouse / T cell / Bone resorption / 病理組織学的検索 / T細胞 / SCIDマウス / ヌードマウス / Tリンパ球 / 骨吸収 Less

上皮細胞のピロトーシス様細胞死抑制による歯周炎発症予防法の開発Principal Investigator
- Principal Investigator
  
  尾崎幸生
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Nagasaki University
インフラマソームプライミングを指標とした歯周病と全身疾患の分子生物学的関連解析
- Principal Investigator
  
  吉村篤利
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Nagasaki University
Effects of NLRP3 inflammasome priming by periodontal diseases on systemic diseases
- Principal Investigator
  
  Yoshimura Atsutoshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Nagasaki University
Bone absorbent promotion by cholesterol crystals deposited in the apex and inhibition by cyclodexttin
- Principal Investigator
  
  SHIRAISHI Chiaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Nagasaki University
Basic study on periodontal destruction by new T cell subset Th17Principal Investigator
- Principal Investigator
  
  OZAKI Yukio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Nagasaki University
ニフェジピン歯肉増殖症における炎症性セリンプロテアーゼの線維芽細胞機能の修飾Principal Investigator
- Principal Investigator
  
  尾崎幸生
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Nagasaki University
Involvement of cytoplasmic membrane-bound granulocyte neutral proteinases in mechanism of periodontal tissue destruction.
- Principal Investigator
  
  KUNIMATSU Kazushi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Nagasaki University
歯肉増殖症の成立機序へのリソゾーム性プロテアーゼの役割に関する基礎的研究Principal Investigator
- Principal Investigator
  
  尾崎幸生
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Conservative dentistry
- Research Institution
  Nagasaki University
カルシウム拮抗剤による歯肉増殖症の成因に関するリソゾーム性プロテアーゼの役割Principal Investigator
- Principal Investigator
  
  尾崎幸生
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Conservative dentistry
- Research Institution
  Nagasaki University
Experimental study of the effect of T cell on alveolar bone resorption induced by bacterial endotoxin
- Principal Investigator
  
  HARA Yoshitaka
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  Nagasaki University

All 2023 2022 2021 2020

All Journal Article Presentation Book

[Book] 日本歯内療法学会が全ての歯科医師に贈る最新トレンド　知っておきたい!根管解剖と基礎コレステロール結晶はRAW-D細胞においてNLRP3インフラマソームを介して破骨細胞形成を促進する2021
- Author(s)
  ALAM Mohammad Ibtehaz, RAUDALES Jorge Luis Montenegro, 山下恭徳, 尾崎幸生, 吉村篤利
- Total Pages
  2
- Publisher
  Quintessence
- Data Source
  KAKENHI-PROJECT-20K09942
[Journal Article] Clinical Efficacy and Safety of Antimicrobial Photodynamic Therapy in Residual Periodontal Pockets during the Maintenance Phase2022
- Author(s)
  Yamashita Yasunori、Mae Megumi、Oohira Masayuki、Ozaki Yukio、Ohba Seigo、Asahina Izumi、Yoshimura Atsutoshi
- Journal Title
  
  Pharmaceuticals
  
  Volume: 15 Issue: 8 Pages: 924-924
- DOI
  10.3390/ph15080924
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09942, KAKENHI-PROJECT-22K17043, KAKENHI-PROJECT-22K21019, KAKENHI-PROJECT-18K17072
[Journal Article] NLRP3 inflammasome negatively regulates RANKL-induced osteoclastogenesis of mouse bone marrow macrophages but positively regulates it in the presence of lipopolysaccharides.2022
- Author(s)
  Mohammad Ibtehaz Alam, Megumi Mae, Fatima Farhana, Masayuki Oohira, Yasunori Yamashita, Yukio Ozaki, Eiko Sakai and Atsutoshi Yoshimura
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 23 Issue: 11 Pages: 6096-6096
- DOI
  10.3390/ijms23116096
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09474, KAKENHI-PROJECT-20K09942, KAKENHI-PROJECT-22K17043, KAKENHI-PROJECT-22K21019, KAKENHI-PROJECT-18K17072
[Journal Article] カルシウム拮抗剤性歯肉増殖症の基礎と臨床2021
- Author(s)
  尾崎幸生, 吉村篤利
- Journal Title
  
  日本歯周病学会会誌
  
  Volume: 63 Pages: 37-46
- NAID
  130008063271
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09942
[Journal Article] Cytotoxic effects of dental calculus particles and freeze‐dried Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum on HSC‐2 oral epithelial cells and THP‐1 macrophages2021
- Author(s)
  Ziauddin S.M.、Alam Mohammad Ibtehaz、Mae Megumi、Oohira Masayuki、Higuchi Kanako、Yamashita Yasunori、Ozaki Yukio、Yoshimura Atsutoshi
- Journal Title
  
  Journal of Periodontology
  
  Volume: － Issue: 6
- DOI
  10.1002/jper.21-0196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09942, KAKENHI-PROJECT-20K18540, KAKENHI-PROJECT-22K17063, KAKENHI-PROJECT-22K20996, KAKENHI-PROJECT-22K21019
[Journal Article] Expression of osteoclastogenic and anti-osteoclastogenic cytokines differs in mouse gingiva injected with lipopolysaccharide, peptidoglycan, or both2021
- Author(s)
  Ozaki Yukio、Kishimoto Takaaki、Yamashita Yasunori、Kaneko Takashi、Higuchi Kanako、Mae Megumi、Oohira Masayuki、Mohammad Alam Ibtehaz、Yanagiguchi Kajiro、Yoshimura Atsutoshi
- Journal Title
  
  Archives of Oral Biology
  
  Volume: 122 Pages: 104990-104990
- DOI
  10.1016/j.archoralbio.2020.104990
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09615, KAKENHI-PROJECT-20K09942, KAKENHI-PROJECT-18K17072
[Journal Article] The Role of Cytokines Produced via the NLRP3 Inflammasome in Mouse Macrophages Stimulated with Dental Calculus in Osteoclastogenesis2021
- Author(s)
  Mae Megumi、Alam Mohammad Ibtehaz、Yamashita Yasunori、Ozaki Yukio、Higuchi Kanako、Ziauddin S. M.、Montenegro Raudales Jorge Luis、Sakai Eiko、Tsukuba Takayuki、Yoshimura Atsutoshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 22 Pages: 12434-12434
- DOI
  10.3390/ijms222212434
- NAID
  120007186852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10092, KAKENHI-PROJECT-19K10112, KAKENHI-PROJECT-20H03860, KAKENHI-PROJECT-20K09474, KAKENHI-PROJECT-20K09942, KAKENHI-PROJECT-21K10047, KAKENHI-PROJECT-18K17072, KAKENHI-PROJECT-20K18540
[Presentation] 人口歯石によるラット実験的歯周炎の骨吸収促進について2023
- Author(s)
  尾崎幸生, Elazegui Ralph, 前めぐみ, 大平真之, 一瀬早紀, 上田明日香, 山下恭徳, 坂本英次郎, 柳口嘉治郎, 吉村篤利
- Organizer
  日本歯周病学会
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] コレステロール結晶はLPS存在下ではIL-1βを介して非存在下ではIL-18を介して破骨細胞形成を促進する2023
- Author(s)
  Alam Mohammad Ibtehaz, 一瀬早紀, 大平真之, 山下恭徳, 尾崎幸生, 柳口嘉次郎, 吉村篤利
- Organizer
  日本歯科保存学会
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] 長崎県五島市住民を対象とした唾液中のPorphyromonas gingivalisレベルとヘモグロビンA1c値の関連についての横断的研究2023
- Author(s)
  大平真之, 北村雅保, 樋口加奈子, 一瀬早紀, 山下恭徳, 尾崎幸生, 五月女さき子, 吉村篤利
- Organizer
  日本歯周病学会
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] Osteoclastogenic and anti-osteoclastogenic cytokines induced by dental calculus2022
- Author(s)
  Megumi Mae, Mohammad Ibtehaz Alam, Yasunori Yamashita, Yukio Ozaki, Masayuki Oohira, Atsutoshi Yoshimura
- Organizer
  第108回アメリカ歯周病学会共催日本臨床歯周病学会・日本歯周病学会2022年大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] Effectiveness of antimicrobial photodynamic therapy in the periodontal maintenance phase2022
- Author(s)
  Yasunori Yamashita, Megumi Mae, Masayuki Oohira, Yukio Ozaki, Atsutoshi Yoshimura
- Organizer
  第108回アメリカ歯周病学会共催日本臨床歯周病学会・日本歯周病学会2022年大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] 音波振動歯ブラシの臨床的有用性の評価2020
- Author(s)
  山下恭徳，前めぐみ，大平真之，樋口賀奈子，Ziauddin S.M.，尾崎幸生，吉村篤利
- Organizer
  第63回日本歯周病学会春季学術大会
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] コレステロール結晶はRAW-D細胞においてNLRP3インフラマソームを介して破骨細胞形成を促進する2020
- Author(s)
  ALAM Ibtehaz Mohammad、山下恭徳、尾崎幸生、吉村篤利
- Organizer
  第41回日本歯内療法学会学術大会
- Data Source
  KAKENHI-PROJECT-20K09942
[Presentation] ペプチドグリカンおよびリポ多糖投与マウス歯槽骨面上の破骨細胞形成におけるIL-10の役割2020
- Author(s)
  尾崎幸生，山下恭徳，前めぐみ，大平真之，Ziauddin SM，Alam IM，樋口賀奈子，金子高士，吉村篤利
- Organizer
  日本歯科保存学会
- Data Source
  KAKENHI-PROJECT-18K09601
[Presentation] Role of quiescent osteoclast precursors in occlusal trauma in mice2020
- Author(s)
  Yasunori Yamashita*, Yukio Ozaki, Kanako Higuchi, Masayuki Oohira, Megumi Mae, Ziauddin S.M., Atsutoshi Yoshimura
- Organizer
  he 106th Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology, the Japanese Academy of Clinical Periodontology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09942

1. YOSHIMURA Atsutoshi (70253680)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
2. HARA Yoshitaka (60159100)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KATO Ihachi (30005087)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 坂本英次郎 (70771624)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 岩下未咲 (80611326)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TANI Masahiko (70188374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ICHIMARU Eiji (60223111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KUNIMATSU Kazushi (20170011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SHIRAISHI Chiaki (30336177)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 鵜飼孝 (20295091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 柳口嘉治郎 (50264255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山下恭徳 (10782568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
13. 金子高士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 坂井詠子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 筑波隆幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OZAKI Yukio 尾崎 幸生

Research Projects

Research Products

Co-Researchers

上皮細胞のピロトーシス様細胞死抑制による歯周炎発症予防法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

インフラマソームプライミングを指標とした歯周病と全身疾患の分子生物学的関連解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of NLRP3 inflammasome priming by periodontal diseases on systemic diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Bone absorbent promotion by cholesterol crystals deposited in the apex and inhibition by cyclodexttin

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic study on periodontal destruction by new T cell subset Th17Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ニフェジピン歯肉増殖症における炎症性セリンプロテアーゼの線維芽細胞機能の修飾Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of cytoplasmic membrane-bound granulocyte neutral proteinases in mechanism of periodontal tissue destruction.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

歯肉増殖症の成立機序へのリソゾーム性プロテアーゼの役割に関する基礎的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

カルシウム拮抗剤による歯肉増殖症の成因に関するリソゾーム性プロテアーゼの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental study of the effect of T cell on alveolar bone resorption induced by bacterial endotoxin

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 日本歯内療法学会が全ての歯科医師に贈る最新トレンド 知っておきたい!根管解剖と基礎 コレステロール結晶はRAW-D細胞においてNLRP3インフラマソームを介して破骨細胞形成を促進する2021

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Clinical Efficacy and Safety of Antimicrobial Photodynamic Therapy in Residual Periodontal Pockets during the Maintenance Phase2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NLRP3 inflammasome negatively regulates RANKL-induced osteoclastogenesis of mouse bone marrow macrophages but positively regulates it in the presence of lipopolysaccharides.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] カルシウム拮抗剤性歯肉増殖症の基礎と臨床2021

OZAKI Yukio 尾崎幸生

[Book] 日本歯内療法学会が全ての歯科医師に贈る最新トレンド　知っておきたい!根管解剖と基礎コレステロール結晶はRAW-D細胞においてNLRP3インフラマソームを介して破骨細胞形成を促進する2021