TAKESHITA Toshikazu 竹下敏一

… Alternative Names

TAKESHITA Toshokazu 竹下敏一

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Researcher Number	60212023
Other IDs
Affiliation (based on the past Project Information) *help	2014 – 2023: 信州大学, 学術研究院医学系, 教授 2013: 信州大学, 医学部, 教授 2009 – 2011: Shinshu University, 医学部, 教授 2000 – 2003: 信州大学, 医学部, 教授 1999: Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 … More 1998: 東北大学, 医学部, 助教授 1994 – 1996: 東北大学, 医学部, 助教授 1991 – 1993: 東北大学, 医学部, 助手 1989 – 1990: 日本学術振興会, 特別研究員 Less
Review Section/Research Field	Principal Investigator Immunology / Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related / Immunology Except Principal Investigator Basic Section 55020:Digestive surgery-related / Immunology / Basic Section 54020:Connective tissue disease and allergy-related / General physiology / Neurology / Biological Sciences
Keywords	Principal Investigator IL-2 / IL-2受容体 / Jak3 / STAM2 / STAM / Hgs / チロシンキナーゼ / SCID / サイトカイン受容体 / シグナル伝達 … More / 川崎病 / 一塩基遺伝子多型 / p38 / STAM1 / IL-2 receptor / γc鎖 / 受容体遺伝子多型 / アレルギー / サイトカイン / 小胞輸送シグナル / 細胞内シグナル伝達 / サイトカイン受容体共通γ鎖 / 単クロン抗体 / γ鎖 / 免疫グロブリン療法不応答 / 冠動脈瘤 / IVIG療法 / IL-2レセプター / 遺伝子多型 / IL-4 / IVIG不応答 / 膠原病学 / 小児免疫 / サイトカインレセプター / インターロイキン4レセプター / apoptosis / Mkk6 / Mkk3 / MAPK / signal transduction / MAP kinase / アポトーシス / MKK6 / MKK3 / MAP Kinase / Graf40 / γc chain / AMSH / the γc chain / ユビキチン / エンドソーム / 小胞輸送 / gene targetting mouse / SARA / Smad / TGF-β / 胎生致死 / ノックアウトマウス / JAK3キナーゼ / IL-9受容体 / IL-7受容体 / 増殖シグナル / チロシレキナーゼ / インターナリゼーション / 高親和性受容体 / γサブユニット … More Except Principal Investigator IL-2 / 細胞遊走 / 細胞骨格 / 腫瘍微小環境 / 転移 / 胆管癌 / S100A10 / HAM / IL-2 receptor / IL-2受容体 / ILー2受容体 / 受容体サブユニット / ILー2 / γ鎖 / チロシンリン酸化 / サイトカインシグナル伝達 / 免疫抑制薬 / シグナル伝達 / エンドソーム / JAK3 / ナノボディ / 転移浸潤 / 癌幹細胞 / 細胞周期 / S100 protein / 細胞浸潤 / ユビキチン / ユビキチン非依存性小胞輸送 / インターロイキン４受容体 / インターロイキン２受容体 / 小胞輸送 / Guillain-Barre syndrome / Myasthenia Gravis / Multiple Sclerosis / beta, gamma chain / Soluble IL2r / 免疫性神経疾患 / α,β,γ鎖 / 可溶性インターロイキン2受容体 / 可溶性インターロイキンン2レセプター / ギランバレー症候群 / 重症筋無力症 / 多発性硬化症 / β,γ鎖 / 可溶性インタロイキン2レセプター / high-affinity receptor / gamma chain / flow cytometry / monoclonal antibody / tyrosine kinase / receptor subunits / monocytes / lymphocytes / チロシン・キナ-ゼ / NK細胞 / CD8 / CD4 / 胸腺細胞 / フロ-サイトメトリ- / 単クロン抗体 / チロシンキナ-ゼ / 単球マクロファ-ジ / リンバ球 / ILー2レセプタ- / アクチビン / Smad / STAM / Hrs / Hgs / IL‐2 / Itk / T細胞 Less

Functional elucidation of S100A10 in the acquisition of invasive and metastatic abilities of cholangiocarcinoma and its development into therapeutic strategies
- Principal Investigator
  
  Kojima Katsuhiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Shinshu University
Elucidation of the spatiotemporal control mechanism of JAK3 activation to discover highly selective JAK3 inhibitors
- Principal Investigator
  
  Amano Yuji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Shinshu University
Single nucleotide variants that could serve as the predictive indicator of intravenous immunoglobulin therapy-unresponsive Kawasaki disease.Principal Investigator
- Principal Investigator
  
  Takeshita toshikazu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Shinshu University
Functional role of S100 proteins in maintenance of the malignant phenotype in cancer stem cells of cholangiocarcinoma
- Principal Investigator
  
  Kojima Katsuhiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Shinshu University
Mutations and single nucleotide polymorphisms of cytokine receptors in Kawasaki diseasePrincipal Investigator
- Principal Investigator
  
  TAKESHITA Toshikazu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University
Endosomal sorting signal of cytokine receptors and its single nucleotide polymorphism in allergy diseasePrincipal Investigator
- Principal Investigator
  
  TAKESHITA Toshikazu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Shinshu University
Ubiquitin-independent endosomal sorting of cytokine receptors
- Principal Investigator
  
  AMANO Yuji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Shinshu University
Identification of ubiquitin-dependent endosomal sorting signal in cytokine receptorsPrincipal Investigator
- Principal Investigator
  
  TAKESHITA Toshikazu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Shinshu University
Control of immunological tolerance and its breakdown by cytokinePrincipal Investigator
- Principal Investigator
  
  TAKESHITA Toshikazu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  SHINSHU UNIVERSITY
Smads活性化に関わるチロシンリン酸化分子Hgsの細胞増殖がん化における役割
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Cytokine receptor γc chain/Jak3 mediated signal transduction and analysis of immunodeficiecy by dysfunction of the γc chain/Jak3Principal Investigator
- Principal Investigator
  
  TAKESHITA Toshikazu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Shinshu University
Smads活性化に関わるチロシンリン酸化分子Hrsの細胞増殖がん化における役割Principal Investigator
- Principal Investigator
  
  竹下敏一
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
サイトカイン受容体を介する新たな増殖シグナル伝達経路“Jak-STAM"Principal Investigator
- Principal Investigator
  
  竹下敏一
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
Cytokine receptor γc chain mediated signal transduction and analysis of immunodeficiency by dysfunction of the γc chainPrincipal Investigator
- Principal Investigator
  
  TAKESHITA Toshokazu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
新規IL-2依存性チロシンリン酸化蛋白分子(pp70)の機能的役割Principal Investigator
- Principal Investigator
  
  竹下敏一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
サイトカイン共通受容体(γc鎖)を介した細胞内情報伝達機構Principal Investigator
- Principal Investigator
  
  竹下敏一
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
新規IL-2依存性チロシンリン酸化蛋白分子(pp70)の機能的役割Principal Investigator
- Principal Investigator
  
  竹下敏一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
サイトカイン共通受容体(γc鎖)を介した細胞内情報伝達機構Principal Investigator
- Principal Investigator
  
  竹下敏一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Investigation on SIL2 receptor, beta gamma in immune nervous system diseases
- Principal Investigator
  
  SEKIZAWA Tsuyoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Tリンパ球特異的チロシンキナーゼItkの細胞増殖分化における役割
- Principal Investigator
  
  NAKAMURA Masataka
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
インターロイキン2受容体γ鎖の発現と機能Principal Investigator
- Principal Investigator
  
  竹下敏一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
IL-2受容体γ鎖の機能ならびに発現制御に関する研究Principal Investigator
- Principal Investigator
  
  竹下敏一
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
IL-2受容体新らたなサブユニットr鎖の機能解析Principal Investigator
- Principal Investigator
  
  竹下敏一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Expression of interleukin 2 receptor subunits and mechanism of T cell growth
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  TOHOKU UNIVERSITY
The Role of IL-2 Receptor Alpha and Beta Chain in Growth and Differentiation of Lymphocytes
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University

All 2023 2022 2021 2014 2011 2010 2009 1999 1998

All Journal Article Presentation

[Journal Article] Essential role of an acidic endosomal environment in JAK3-mediated signal transduction2023
- Author(s)
  Amano Yuji、Tanaka Nobuyuki、Takeshita Toshikazu、Kojima Katsuhiko
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2023.09.07.556780
- Open Access
- Data Source
  KAKENHI-PROJECT-21K08474
[Journal Article] MK‐6, a novel not‐α IL‐2, elicits a potent antitumor activity by improving the effector to regulatory T cell balance2021
- Author(s)
  Kobayashi Maki、Kojima Katsuhiko、Murayama Kazutaka、Amano Yuji、Koyama Takashi、Ogama Naoko、Takeshita Toshikazu、Fukuhara Tatsuro、Tanaka Nobuyuki
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 11 Pages: 4478-4489
- DOI
  10.1111/cas.15127
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08203, KAKENHI-PROJECT-20K08580, KAKENHI-PROJECT-21K08795
[Journal Article] ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation2014
- Author(s)
  Kojima, K., Amano, Y., Yoshino, K., Tanaka, N., Sugamura, K., Takeshita, T.
- Journal Title
  
  J Biol Chem
  
  Volume: 289 Issue: 48 Pages: 33296-33310
- DOI
  10.1074/jbc.m114.578245
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-25461586, KAKENHI-PROJECT-25860161
[Journal Article] Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting2011
- Author(s)
  Amano Y, Yamashita Y, Tanaka N, Sugamura K, 他
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 17 Pages: 15458-15472
- DOI
  10.1074/jbc.m110.191924
- NAID
  120007110518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590517, KAKENHI-PROJECT-21590530, KAKENHI-PROJECT-22591925
[Journal Article] Grf40, a novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT.1999
- Author(s)
  Asada, H., Ishii, N., Sasaki, Y., Endo, K., Kasai, H., Tanaka, N., Takeshita, T., Tsuchiya, S., Konno, T., Sugamura, K.
- Journal Title
  
  J.Exp.Med. Vol.189
  
  Pages: 1383-1390
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10470084
[Journal Article] Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediate by cytokines.1999
- Author(s)
  Tanaka, N., Kaneko, K., Asao, H., Kasai, H., Endo, Y., Fujita, T., Takeshita, T., Sugamura K.
- Journal Title
  
  J.Biol.Chem. Vol.274
  
  Pages: 19129-19135
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10470084
[Journal Article] Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108.1999
- Author(s)
  Yamada, A., Kubo, K., Takeshita, T., Harashima, N., Kawano, K., Mine, T., Sagawa, K., Sugamura, K., Itoh, K.
- Journal Title
  
  J.Immunol. Vol.162
  
  Pages: 4094-4100
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10470084
[Journal Article] Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family.1999
- Author(s)
  Abe, H., Takeshita, T., Nagata, K., Arita, T., Endo, Y., Fujita, T., Takayama, H., Kubo, M., Sugamura, K.
- Journal Title
  
  Gene Vol.227
  
  Pages: 71-77
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10470084
[Journal Article] Prolongation of allograft survival by administration of mAb specific for the three subunis of IL-2 receptor.1998
- Author(s)
  Yasuda, K., Nemoto, T., Ohashi, Y., Satomi, S., Mutara, K., Ishii, N., Takeshita, T., Sugamura, K.
- Journal Title
  
  Int.Immunol. Vol.10
  
  Pages: 561-567
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10470084
[Presentation] Tyro3-Gas6およびTyro3-Protein S複合体は、リン脂質結合によりCD63陽性エクソソームを細胞内に取り込む2022
- Author(s)
  小山昂志、小嶋克彦、前田昂樹、竹下敏一、森田英嗣、田中伸幸
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K08795
[Presentation] TYRO3はGAS6を介してフォスファチジルセリンに結合することでエクソソームを取り込む2022
- Author(s)
  小山昂志、小嶋克彦、前田昂樹、竹下敏一、森田英嗣、田中伸幸
- Organizer
  第9回日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08795
[Presentation] Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting2011
- Author(s)
  天野勇治、小嶋克彦、吉野和寿、竹下敏一
- Organizer
  日本免疫学会
- Place of Presentation
  千葉
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] Identification of Hrs-binding motif in the cytokine receptors delivered to lysosome in ubiquitin-independent manner2010
- Author(s)
  天野勇治、小嶋克彦、山下勇毅、吉野和寿、竹下敏一
- Organizer
  国際免疫学会
- Place of Presentation
  神戸
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] Identification of Hrs-binding motif in the cytokine receptors delivered to lysosome in ubiquitin-independent manner2010
- Author(s)
  天野勇治、小嶋克彦、山下勇毅、吉野和寿、竹下敏一
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] ユビキチン非依存的に小胞輸送されるサイトカイン受容体のHrs会合モチーフの同定2009
- Author(s)
  天野勇治、小嶋克彦、山下勇毅、吉野和寿、竹下敏一
- Organizer
  日本免疫学会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21590530
[Presentation] 細胞内小胞輸送と細胞増殖におけるIL-2受容体β鎖のHrs結合領域の役割2009
- Author(s)
  山下勇毅、小嶋克彦、天野勇治、吉野和寿、竹下敏一
- Organizer
  日本免疫学会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21590530

1. KOJIMA Katsuhiko (80345743)

# of Collaborated Projects: 6 results

# of Collaborated Products: 7 results
2. AMANO Yuji (50624681)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
3. YOSHINO Kazuhisa (40551859)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
4. TANAKA Nobuyuki (60280872)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. ISHII Naoto (60291267)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
6. 浅尾裕信 (80250744)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. NAKAMURA Masataka (30180392)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SUGAMURA Kazuo (20117360)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. OHTANI Kiyoshi (30201974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SEKIZAWA Tsuyoshi (50150264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ITOYAMA Yasto (30136428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大保和之 (70250751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKESHITA Toshikazu 竹下 敏一

TAKESHITA Toshokazu 竹下 敏一

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Single nucleotide variants that could serve as the predictive indicator of intravenous immunoglobulin therapy-unresponsive Kawasaki disease.Principal Investigator

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Principal Investigator

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Mutations and single nucleotide polymorphisms of cytokine receptors in Kawasaki diseasePrincipal Investigator

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Endosomal sorting signal of cytokine receptors and its single nucleotide polymorphism in allergy diseasePrincipal Investigator

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Identification of ubiquitin-dependent endosomal sorting signal in cytokine receptorsPrincipal Investigator

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Control of immunological tolerance and its breakdown by cytokinePrincipal Investigator

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Principal Investigator

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Review Section

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Cytokine receptor γc chain/Jak3 mediated signal transduction and analysis of immunodeficiecy by dysfunction of the γc chain/Jak3Principal Investigator

Principal Investigator

Project Period (FY)

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Smads活性化に関わるチロシンリン酸化分子Hrsの細胞増殖がん化における役割Principal Investigator

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サイトカイン受容体を介する新たな増殖シグナル伝達経路“Jak-STAM"Principal Investigator

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Cytokine receptor γc chain mediated signal transduction and analysis of immunodeficiency by dysfunction of the γc chainPrincipal Investigator

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TAKESHITA Toshikazu 竹下敏一

TAKESHITA Toshokazu 竹下敏一