• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

MISAKI Yoshiikata  三崎 義堅

ORCIDConnect your ORCID iD *help
… Alternative Names

三さき 義堅  ミサキ ヨシカタ

三崎 義堅  ミサキ ヨシタカ

Less
Researcher Number 60219615
External Links
Affiliation (based on the past Project Information) *help 2001 – 2007: 東京大学, 医学部附属病院, 講師
1998 – 2001: 東京大学, 医学部・附属病院, 講師
1996 – 1997: 九州大学, 生体防御医学研究所, 講師
1995: 東京大学, 医学部(病), 医員
1991: 東京大学, 医学部・(病)物療内科, 助手
1990: 東京大学, 医学部・物療内科, 助手
Review Section/Research Field
Principal Investigator
膠原病・アレルギー・感染症内科学 / Biological Sciences / 内科学一般
Except Principal Investigator
内科学一般 / Circulatory organs internal medicine
Keywords
Principal Investigator
自己免疫疾患 / 制御性T細胞 / 転写因子 / FOXP3 / レトロウイルスベクター / SOCS3 / transcription factors / autoimmune diseases / regulatory T cells / 免疫制御 … More / B細胞 / 自己抗体 / autoimmune disease / transcription factor / retrovirus vector / yeast two hybrid / regulatory T cell / レトロウィルスベクター / レトロウイルススペクター / 酵母2ハイブリッド / ホメオスタシス / トランスジェニックマウス / cDNAクローニング / 分化誘導 / 転子因子 / antigen-specific therapy / CD4^+CD25^+ T cells / Tr1 / Th3 / 再分化 / CD4(+)CD25(+)T細胞 / T細胞サブセット / 調節性T細胞 / 自己免疫病 / self / anto antibody / dendritic cell / anergy / OVA / antoimmune disease / anto antigen / Tolerance / 末梢性免疫学的寛容 / 自己抗原 / 自己免疫応答 / 卵白アルブミン / 卵日アルブミン / 核内抗原 / 免疫学的寛容 / 自己抗原特異的T細胞 / 強皮症 / 全身性エリテマトーデス / 機能性RNA / NFκB / 免疫応答増強 / インターフェロンγ / Th1型免疫応答 / 核内転写因子 / PPARγ / 細胞増殖停止 / 抑制信号 / 増殖停止信号 / ras / 共刺激 / 細胞内信号伝達 / 制御刺激 / T細胞 / 制御機構 / 細胞周期遅延 / 免疫寛容 / 細胞周期 / 低反応性 / アナジー / プリスタン誘導自己免疫病 / リンパ球 / レトロウィルス / 螢光Differential Display / トランスクリプトーム … More
Except Principal Investigator
T細胞レセプター / T細胞 / T-cell receptor / dilated cardiomyopathy / myocarditis / T cells / IL-10 / ligand superfamily / TNF receptor / costimulatory molecule / immunotherapy / Takayasu Arteritis / T cell receptor / T細胞クローン / cell-mediated immunity / 自己抗体 / 自己抗原 / pathogenic T cell / epitope / autommune disease / 病態形成性T細胞 / エピトープ / 自己免疫 / dendritic cells / Peyer's patch / Oral tolerance / 樹状細胞 / パイエル板 / 経口トレランス / auto-antigen / arteritis / dilated cardimyopathy / cell therapy / gene transduction / antigen-specific immunotherapy / Immune diseases / レトロウイルス / レトロウィルス / リンパ球 / 免疫細胞療法 / 遺伝子導入 / 抗原特異的免疫療法 / 免疫疾患 / レトロウィルスベクター / 免疫制御 / NKT細胞 / DNA免疫 / 動物モデル / 樹状細胞免疫 / 自己免疫応答 / バキュロウィルス / トポイソメラーゼI / 強皮症 / 腫瘍免疫 / C末端srcキナーゼ / src型キナーゼ / ノックアウトマウス / PAF受容体 / PAF / LPS / リポ多糖体 / エンドトキシンショック / リコンビナント抗原 / 分子生物学 / エピト-プ / 自己免疫疾患 Less
  • Research Projects

    (19 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (13 People)
  •  RNAによる制御性T細胞特異的転写因子機能修飾機構の解明による関節リウマチの治療Principal Investigator

    • Principal Investigator
      三崎 義堅
    • Project Period (FY)
      2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      The University of Tokyo
  •  The development of an innovative therapy for autoimmune diseases by controlling FOXP3, a unique transcription factors of the regulatory T cellsPrincipal Investigator

    • Principal Investigator
      MISAKI Yoshikata
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      The University of Tokyo
  •  The development of an innovative therapy for autoimmune diseases by controlling transcription factors in the regulatory T cells.Principal Investigator

    • Principal Investigator
      YOSHIKATA Misaki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      The University of Tokyo
  •  PPARγを標的としたB細胞機能活性化による抗原特異的免疫応答増強法の開発Principal Investigator

    • Principal Investigator
      三崎 義堅
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Evidence against epitope spreading of T cells in autoimmune diseases.

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  アナジー誘導反復抗原刺激における抗原受容体を介するT細胞増殖停止信号伝達機構Principal Investigator

    • Principal Investigator
      三崎 義堅
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  The development of Autoimmune-diseases antigen-specific therapy by the induction of regulatory T cells transcription factorsPrincipal Investigator

    • Principal Investigator
      MISAKI Yoshikata
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  自己免疫病誘導モデルを用いた、病態形成に関与する遺伝子の疾患誘導能の解析Principal Investigator

    • Principal Investigator
      三崎 義堅
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  抗原特異的T細胞レセプターを導入したNKT細胞による抗原特異的免疫制御の可能性

    • Principal Investigator
      山本 一彦
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  Establishment of antigen-specific regulatory T cell lines induced by oral tolerance and the application to immunotherapy

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  拡張型心筋症(慢性心筋炎)のモデル動物の作成と治療法開発への応用

    • Principal Investigator
      SEKO Yoshinori
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  Establishment of antigen-specific immunotherapy with artificial lymphocytes genetically engineered by antigen specific receptor and functional genes.

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  Development of the Specific Immunotherapy for Myocarditis, Dilated Cardiomyopathy(Chronic Myocarditis), and Takayasu Arteritis.

    • Principal Investigator
      SEKO Yoshinori
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Tokyo
  •  Analysis of Immunological Tolerance to a nuclear autoantigen using transgenic mcie.Principal Investigator

    • Principal Investigator
      MISAKI Yoshikata
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  強皮症におけるトポイソメラーゼIに対する自己免疫応答とその病態との関連の解析Principal Investigator

    • Principal Investigator
      三崎 義堅, 瀬戸口 京吾
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
      Kyushu University
  •  固形癌局所に浸潤、集積しているT細胞の抗原レセプター機能の試験管内再構築

    • Principal Investigator
      山本 一彦
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  エンドトキシンショックにおける脂質伝達物質の役割に関する研究

    • Principal Investigator
      本田 善一郎
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  自己免疫疾患における自己抗原反応性T細胞の分子生物学的解析

    • Principal Investigator
      山本 一彦
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  自己抗体産生機序におけるエピト-プ・プログレッション現象の分子生物学的解析

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo

All 2008 2007 2006 2005 2004 2003 Other

All Journal Article Book

  • [Book] 疾病の成り立ち II. 臓器別の病気 第18章 自己免疫疾患および膠原病(近藤和雄、脊山洋右、藤原葉子、森田寛編)(p214-222)2007

    • Author(s)
      三崎義堅
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PROJECT-17591032
  • [Book] 炎症とPPARs 生活習慣病とPPARs (藤田敏郎編)(p24-28)2007

    • Author(s)
      三崎義堅
    • Publisher
      ライフサイエンス出版
    • Data Source
      KAKENHI-PROJECT-17591032
  • [Book] 膠原病におけるregulatory T細胞の異常(リウマチ・膠原病 最新トピックスP15-18)2005

    • Author(s)
      三崎 義堅
    • Total Pages
      4
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-17591032
  • [Journal Article] Severe airflow limitation in two patients with systemic lupus erythematosus: effect of inhalation of anticholinergics.2008

    • Author(s)
      Kawahata K, Yamaguchi M, Kanda H, , Misaki Y, et. al.
    • Journal Title

      Mod Rheumatol. 18(1)

      Pages: 52-56

    • NAID

      10024149772

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591157
  • [Journal Article] Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes.2007

    • Author(s)
      Takizawa Y, Kanda H, Sato K, Kawahata K, Yamaguchi A, Uozaki H, Shimizu J, Tsuji S, Misaki Y, et. al.
    • Journal Title

      Clin Rheumatol. 26(5)

      Pages: 792-796

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591157
  • [Journal Article] Epstein-Barr virus-associated mononucleosis caused by weekly low-dose methotrexate therapy in a rheumatoid arthritis patient2006

    • Author(s)
      Shoda H, Nakazaki K, Izutsu K, Tanaka R, Komagata Y, Misaki Y, Yamamoto K
    • Journal Title

      Scand J Rheumatol 35 (2)

      Pages: 152-153

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591032
  • [Journal Article] Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes.2006

    • Author(s)
      Takizawa Y, Kanda H, Sato K, Kawahata K, Yamaguchi A, Uozaki H, Shimizu J, Tsuji S, Misaki Y, Yamamoto K.
    • Journal Title

      Clin Rheumatol. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591032
  • [Journal Article] Epstein-Barr virus-associated mononucleosis caused by weekly low-dose methotrexate therapy in a rheumatoid arthritis patient.2006

    • Author(s)
      Shoda H, Nakazaki K, Izutsu K, Tanaka R, Komagata Y, Misaki Y, Yamamoto K.
    • Journal Title

      Scand J Rheumatol. 35(2)

      Pages: 152-153

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591032
  • [Journal Article] Epstein-Barr virus-associated mononucleosis caused by weekly low-dose methotrexate therapy in a rheumatoid arthritis patient.2006

    • Author(s)
      Shoda H, Nakazaki K, Izutsu K, Tanaka R, Komagata Y, Misaki Y, Yamamoto K.
    • Journal Title

      Scand J Rheumatol 35(2)

      Pages: 152-153

    • Data Source
      KAKENHI-PROJECT-17591032
  • [Journal Article] Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes.2006

    • Author(s)
      Takizawa Y, Kanda H, Misaki Y, et al.
    • Journal Title

      Clin Rheumatol. (in press)

    • Data Source
      KAKENHI-PROJECT-17591032
  • [Journal Article] Wegener's granulomatosis with eosinophilia.2005

    • Author(s)
      Shoda H, Kanda H, Tanaka R, Misaki Y, Yamamoto K. et al.
    • Journal Title

      Intern Med. 44(7)

      Pages: 750-753

    • NAID

      10016607854

    • Data Source
      KAKENHI-PROJECT-17591032
  • [Journal Article] Wegener's grariulomatosis with eosinophilia.2005

    • Author(s)
      Shoda H, Kanda H, Tanaka R, Komagata Y, Misaki Y, Yamamoto K
    • Journal Title

      Intern Med 44 (7)

      Pages: 750-753

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591032
  • [Journal Article] Wegener's granulomatosis with eosinophilia.2005

    • Author(s)
      Shoda H, Kanda H, Tanaka R, Komagata Y, Misaki Y, Yamamoto K.
    • Journal Title

      Intern Med. 44(7)

      Pages: 750-753

    • NAID

      10016607854

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591032
  • [Journal Article] T cells accumulating in the inflamed joints of a spontaneous murine model of rheumatoid arthritis become restricted to common clonotypes during disease progession.2004

    • Author(s)
      Kobari Y, Misaki Y et al.
    • Journal Title

      International Immunology 16

      Pages: 131-138

    • Data Source
      KAKENHI-PROJECT-15591050
  • [Journal Article] T cell accumulating in the inflamed joints of a spontaneous murine model of rheumoid arthritis become restricted to common clonotypes during disease progression2004

    • Author(s)
      Kobari Y, Misaki Y et al.
    • Journal Title

      International Immunology 16

      Pages: 131-138

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591050
  • [Journal Article] T cells accumulating in the inflamed joints of a spontaneous murine model of rheumatoid arthritis become restricted to common clonotypes during disease progression.2004

    • Author(s)
      Kobari Y, Misaki Y, Setoguchi K, Zhao W, Komagata Y, Kawahata K, Iwakura Y, Yamamoto K.
    • Journal Title

      International Immunology 16(1)

      Pages: 131-138

    • NAID

      10013082886

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591050
  • [Journal Article] Chondromodulin-I, a cartilage-derived angiogenesis inhibitory factor, suppresses T cell response ; an implication of a therapeutic potential for the treatment of arthritis.2004

    • Author(s)
      Setoguchi K, Misaki Y, Kawahata K, Shimada, K Takuo J, Tanaka S, Oda H, Chisa Shukunami C, Nishizaki Y, Hiraki Y, Yamamoto K.
    • Journal Title

      Arthritis & Rheumatism. 50(3)

      Pages: 828-839

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591050
  • [Journal Article] Chondromodulin-I, a cartilage-derived angiogenesis inhibitory factor, suppresses T cell response2004

    • Author(s)
      Setoguchi K, Misaki Y et al.
    • Journal Title

      Arthritis & Rheumatism 50

      Pages: 828-839

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591050
  • [Journal Article] Chondromodulin-I, a cartilage-derived angiogenesis inhibitory factor, suppresses T cell respose.2004

    • Author(s)
      Setoguchi K, Misaki Y et ai.
    • Journal Title

      Arthritis & Rheumatism 50

      Pages: 828-839

    • Data Source
      KAKENHI-PROJECT-15591050
  • [Journal Article] Reconstitution of CD8 T cells by retroviral transfer of TCR αβ-chain genes isolated from a colonally expanded P815-infiltrating lymphocyte2003

    • Author(s)
      Tahara H, Misaki Y, Yamamoto K et al.
    • Journal Title

      J Immunology 171

      Pages: 2154-2160

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591050
  • [Journal Article] Evaluation of functional disability using the health assessment questionnaire Japanese Patients with Systemic Sclerosis2003

    • Author(s)
      Kuwana M, Sato S, Misaki Y et al.
    • Journal Title

      J.Rheumatology 30

      Pages: 1253-1258

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591050
  • [Journal Article] Systemic lupus erythematosus and thrombotic thrombocytopenic purpura : a case report and literature review.2003

    • Author(s)
      Hamasaki K, Mimura T, Kanda H, Kubo K, Setoguchi K, Satoh T, Misaki Y, Yamamoto K.
    • Journal Title

      Clin Rheumatol. 22(4-5)

      Pages: 355-358

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591050
  • [Journal Article] Evaluation of functional disability using the health assessment questionnaire in Japanese patients with systemic sclerosis.2003

    • Author(s)
      Kuwana M, Sato S, Kikuchi K, Kawaguchi Y, Fujisaku A, Misaki Y, Hatamochi A, Kondo H, Takehara K.
    • Journal Title

      J Rheumatol. 30(6)

      Pages: 1253-1258

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591050
  • [Journal Article] Systemic lupus erythematosus and thrombotic thrombocytopenic2003

    • Author(s)
      Hamasaki K, Kanda H, Misaki Y et al.
    • Journal Title

      Clin.Rheumatology 22

      Pages: 355-358

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591050
  • [Journal Article] Reconstitution of CD8+ T cells by retroviral transfer of the TCR alphabeta-chain genes isolated from a clonally expanded P815-infiltrating lymphocyte.2003

    • Author(s)
      Tahara H, Fujio K, Araki Y, Setoguchi K, Misaki Y, Kitamura T, Yamamoto K.
    • Journal Title

      J Immunol. 171(4)

      Pages: 2154-2160

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591050
  • [Journal Article] Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes

    • Author(s)
      Takizawa Y, Kanda H, Sato K, Kawahata K, Yamaguchi A, Uozaki H, Shimizu J, Tsuji S, Misaki Y, Yamamoto K
    • Journal Title

      Clin Rheumatol (in press)

    • Data Source
      KAKENHI-PROJECT-17591032
  • [Journal Article] Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes.

    • Author(s)
      Takizawa Y, Kanda H, Sato K, Kawahata K, Yamaguchi A, Uozaki H, Shimizu J, Tsuji S, Misaki Y, Yamamoto K
    • Journal Title

      Clin Rheumatol. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591032
  • 1.  YAMAMOTO Kazuhiko (80191394)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 2.  DOHI Makoto (60222155)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  KAWAHATA Kimito (70334406)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 4.  SEKO Yoshinori (30240708)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  YAMAGUCHI Akihiro (90261974)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  瀬戸口 京吾 (00284571)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  SAWADA Tetsuji (50235470)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KOMAGATA Yoshinori (60281995)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  本田 善一郎 (70238814)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  清水 孝雄 (80127092)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  塩川 左斗志 (20215940)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  北村 俊雄 (20282527)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  當間 重人 (50207528)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi