WAGA Shou 和賀祥

… Alternative Names

和賀祥ワガシヨウ

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Researcher Number	60222402
Other IDs
External Links
Affiliation (Current)	2025: 日本女子大学, 理学部, 教授
Affiliation (based on the past Project Information) *help	2010 – 2017: 日本女子大学, 理学部, 教授 2008 – 2009: Japan Women's University, 理学部, 准教授 2007: Osaka University, 生命機能研究科, 准教授 2002 – 2006: 大阪大学, 生命機能研究科, 助教授 2003: 大阪大学, 大学院・生命機能研究科, 助教授 2000 – 2001: Osaka University, Graduate School of Frontier Biosciences, Associate Professor, 微生物病研究所, 助教授
Review Section/Research Field	Principal Investigator Biological Sciences / Molecular biology Except Principal Investigator Molecular biology
Keywords	Principal Investigator DNA複製 / ORC / 複製開始点 / 分子生物学 / グアニン四重鎖 / アフリカツメガエル卵抽出液 / EBNA1 / Xenopus egg extract / BLM helicase / Bloom syndrome … More / DNA replication / BLMヘリカーゼ / ブルーム症候群 / RNA結合 / 機能性RNA / 非コードRNA / EBウイルス / MCM / 複製開始因子 / pre-RC形成 / 複製フォーク / oriP / EB ウイルス / アフリカツメガエル / ウェルナー症候群 / DNAヘリカーゼ / 複製因子 / DNAポリメラーゼε / replication fork arrest / Xenopus卵抽出液 / DNAポリメラーゼδ / Bloom症候群 / ウエルナー症候群 / DNAポリメラーゼ / Werner症候群 / ゲノム安定性 … More Except Principal Investigator 複製開始点 / ライセンシング制御 / ヒストンシャペロン / 複製開始制御 / 次世代シークエンシング / クロマチン / MCM / ヒストンシャペロ / 細胞周期 / 複製開始複合体 / Cdt1 / GRWD1 / Dbf4 protein kinase / pre RC (複製開始名複合体) / 複製開始 / セントロメア / アフリカツメガエル卵粗抽出液 / Polε複合体 / GINS / Db4f protein kinase / Cdc / Mcm蛋白 / pre RC(複製開始前複合体) / ほ乳動物細胞 / In vitro DNA複製 / チェックポイント / 哺乳動物細胞 / 出芽酵母 / アフリカツメガエル / DNAポリメラーゼ / 染色体複製 Less

The roles of the G-quadruplex-binding activity of human ORC in replication origin establishmentPrincipal Investigator
- Principal Investigator
  
  Waga Shou
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Japan Women's University
Analysis of the structure and function of the RNA bound by human ORCPrincipal Investigator
- Principal Investigator
  
  WAGA SHOU
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Japan Women's University
Analysis of GRWD1, a novel histone-binding protein involved in chromosomal replication initiation and segregation
- Principal Investigator
  
  FUJITA Masatoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  Kyushu University
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
A novel role of RNA in the function at the replication origins in animal cellsPrincipal Investigator
- Principal Investigator
  
  WAGA Shou
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Japan Women's University
宿主と連携したEBウイルスDNA複製開始機構の解明と人工複製開始点構築への応用Principal Investigator
- Principal Investigator
  
  和賀祥
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japan Women's University
真核生物の染色体複製における複製フォークの機能とその制御Principal Investigator
- Principal Investigator
  
  和賀祥
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
真核生物染色体DNA複製フォークの分子ダイナミズム
- Principal Investigator
  
  杉野明雄
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Molecular biology
- Research Institution
  Osaka University
真核生物複製フォークの染色体複製およびゲノム安定性維持における役割Principal Investigator
- Principal Investigator
  
  和賀祥
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Functions of the Bloom syndrome gene product and the mechanism of genome instabilityPrincipal Investigator
- Principal Investigator
  
  WAGA Shou
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University

All 2017 2016 2015 2013 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] 細胞核の分子生物学-クロマチン・染色体・核構造-(水野重樹編)2005
- Author(s)
  和賀祥(分担執筆)
- Total Pages
  208
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-17013054
[Journal Article] Regulation of the Rev1-Pol zeta complex during bypass of a DNA interstrand crosslink2015
- Author(s)
  Budzowska, M., Graham, T.G.W., Sobeck, A., Waga, S., Walter, J.C.
- Journal Title
  
  EMBO J.
  
  Volume: 34 Issue: 14 Pages: 1971-1985
- DOI
  10.15252/embj.201490878
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06956
[Journal Article] Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA.2013
- Author(s)
  Hoshina S
- Journal Title
  
  The Journal of Biologocal Chemistry
  
  Volume: 288 Issue: 42 Pages: 30161-30171
- DOI
  10.1074/jbc.m113.492504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370071, KAKENHI-PROJECT-24570200, KAKENHI-PLANNED-25116004, KAKENHI-PUBLICLY-25125702, KAKENHI-PUBLICLY-25131701
[Journal Article] Continued primer synthesis at stalled replication forks contributes to checkpoint activation2010
- Author(s)
  Christopher Van, Shan Yan, W. Matthew Michael, Shou Waga and Karlene A. Cimprich
- Journal Title
  
  J. Cell Biol
  
  Volume: 189 Pages: 233-246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21657045
[Journal Article] Redundant and differential regulation of multiple licensing factors ensures prevention of rereplication in normal human cells2009
- Author(s)
  Sugimoto, N., Yoshida, K., Tatsumi, Y., Yugawa, T., Narisawa-Saito, M., Waga, S., Kiyono, T. & Fujita, M.
- Journal Title
  
  J. Cell Sci
  
  Volume: 122 Pages: 1184-1191
- Data Source
  KAKENHI-PROJECT-21370084
[Journal Article] Redundant and differential regulation of multiple licensing factors ensures prevention of replication in normal human cells2009
- Author(s)
  Nozomi Sugimoto, Kazumasa Yoshida, Yasutoshi Tatsumi, Takashi Yugawa, Mako Narisawa-Saito, Shou Waga, Tohru Kiyono and Masatoshi Fujita
- Journal Title
  
  Journal of Cell Science
  
  Volume: 122 Pages: 1184-1191
- Data Source
  KAKENHI-PROJECT-21657045
[Journal Article] Dynamics of DNA binding of replication initiation proteins during de novo formation of pre-replicative complexes in Xenopus egg extracts2006
- Author(s)
  Shou Waga
- Journal Title
  
  Journal of Biological Chemistry in press
- Data Source
  KAKENHI-PROJECT-17013054
[Journal Article] Dynamics of DNA binding of replication initiation proteins during de novo formation of pre-replicative complexes in Xenopus egg extracts2006
- Author(s)
  Shou Waga
- Journal Title
  
  Journal of Biological Chemistry 281・16
  
  Pages: 10926-10934
- Data Source
  KAKENHI-PROJECT-17013054
[Journal Article] DNA複製と染色体不安定性2004
- Author(s)
  和賀祥
- Journal Title
  
  医学のあゆみ 208・10
  
  Pages: 805-810
- Data Source
  KAKENHI-PROJECT-13214057
[Journal Article] DNA replication and chromosome instability2004
- Author(s)
  Shou Waga
- Journal Title
  
  IGAKU NO AYUMI 208
  
  Pages: 805-810
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213073
[Journal Article] DNA複製と染色体不安定性2004
- Author(s)
  和賀祥
- Journal Title
  
  医学のあゆみ 208
  
  Pages: 805-810
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12213073
[Presentation] 複製開始因子／転写抑制因子AlF-C2の転写依存的なDNA結合の解析2017
- Author(s)
  青木麻央、島田真衣、斎藤靖史、和賀　祥
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K06956
[Presentation] ヒトおよびアフリカツメガエルORCAとORCとの結合に関する解析2017
- Author(s)
  石川友紀、由良敬、小布施力史、和賀祥
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K06956
[Presentation] Further characterization of the binding of human ORC to G-quadruplex-formable single-stranded DNA2017
- Author(s)
  Shou Waga, Moe Nakatsuka, Haruka Horinouchi, and Shoko Hoshina
- Organizer
  Cold Spring Harbor Laboratory Meeting on Eukaryotic DNA Replication and Genome Maintenance
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06956
[Presentation] ヒトORC1のN末端側領域の機能解析2017
- Author(s)
  中塚萌、堀之内遥香、溝部彩子、由良敬、和賀祥
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K06956
[Presentation] ヒトORC2におけるORCA結合領域の同定2016
- Author(s)
  石川友紀、及川郁子、坂井実華、由良敬、小布施力史、和賀祥
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K06956
[Presentation] ヒトORC1サブユニットのN末端側領域の機能解析2016
- Author(s)
  女部田寛子、保科祥子、寺西帆奈美、山﨑翠、橋本麻美子、太田黒恵美、由良敬、和賀祥
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K06956
[Presentation] アミノ末端側領域を欠いたORC1サブユニットを含む変異ORCの一本鎖DNA結合活性の解析2016
- Author(s)
  保科祥子、和賀祥
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K06956
[Presentation] 複製開始因子／転写抑制因子AlF-C2のDNA結合における転写の影響2015
- Author(s)
  塚澤真衣、中島ゆいな、星野宏味、斎藤靖史、堤　賢一、和賀　祥
- Organizer
  第３８回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K06956
[Presentation] 動物細胞のDNA複製開始点の確立機構の解明に向けて2015
- Author(s)
  和賀　祥、山﨑　翠、塚澤真衣、鈴木香菜、女部田寛子、寺西帆奈美、太田黒恵美、弓井絵利夏、由良　敬、保科祥子
- Organizer
  第３８回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-15K06956
[Presentation] ヒトORCのDNA結合に及ぼす転写の影響のin vitro解析2015
- Author(s)
  山﨑　翠、保科祥子、弓井絵利夏、和賀祥
- Organizer
  第３８回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K06956
[Presentation] Preferential binding of human origin recognition complex to G-quadruplex-formable RNA and single-stranded DNA2013
- Author(s)
  Shoko Hoshina, Honami Teranishi, Noriko Kiyasu, Ayumi Tominaga, Haruka Kadoma, Ayaka Nakatsuka, Kei Yura, Shou Waga
- Organizer
  Cold Spring Harbor Laboratory Meeting on Eukaryotic DNA Replication and Genome Maintenance
- Place of Presentation
  Cold Spring Harbor, NY, USA
- Data Source
  KAKENHI-PROJECT-24570200
[Presentation] ヒトORCのグアニン四重鎖形成可能なRNAおよび一本鎖DNAへの特異的な結合とその複製開始点形成への関与の可能性2013
- Author(s)
  保科祥子、寺西帆奈美、中塚彩花、由良敬、和賀祥
- Organizer
  第２２回DNA複製・組換え・修復ワークショップ
- Place of Presentation
  仙台（秋保）
- Data Source
  KAKENHI-PROJECT-24570200
[Presentation] ヒトORCのG-rich一本鎖DNAへの結合における塩基配列要求性2013
- Author(s)
  保科祥子、和賀祥
- Organizer
  第３６回分子生物学会年会
- Place of Presentation
  神戸（神戸ポートアイランド）
- Data Source
  KAKENHI-PROJECT-24570200
[Presentation] ヒトORC1の新規RNA結合ドメインの同定とその性状解析2013
- Author(s)
  寺西帆奈美、保科祥子、由良敬、和賀祥
- Organizer
  第２２回DNA複製・組換え・修復ワークショップ
- Place of Presentation
  仙台（秋保）
- Data Source
  KAKENHI-PROJECT-24570200
[Presentation] ヒトORCのG-rich一本鎖DNAへの結合における塩基配列要求性2013
- Author(s)
  保科祥子、和賀祥
- Organizer
  第２２回DNA複製・組換え・修復ワークショップ
- Place of Presentation
  仙台（秋保）
- Data Source
  KAKENHI-PROJECT-24570200
[Presentation] ヒトORCのグアニン四重鎖形成可能なRNAおよび一本鎖DNAへの特異的な結合とその複製開始点形成への関与の可能性2013
- Author(s)
  保科祥子、寺西帆奈美、中塚彩花、由良敬、和賀祥
- Organizer
  第３６回分子生物学会年会
- Place of Presentation
  神戸（神戸ポートアイランド）
- Data Source
  KAKENHI-PROJECT-24570200
[Presentation] ヒトORC1の新規RNA結合ドメインの同定とその性状解析2013
- Author(s)
  寺西帆奈美、保科祥子、由良敬、和賀祥
- Organizer
  第３６回分子生物学会年会
- Place of Presentation
  神戸（神戸ポートアイランド）
- Data Source
  KAKENHI-PROJECT-24570200
[Presentation] Possible roles of RNA in origin selection through two distinct mechanisms involving direct interactions of RNA with DNA, a transcription factor and human origin recognition complex2011
- Author(s)
  Shou Waga
- Organizer
  Cold Spring Harbor Laboratory Meeting for eukaryotic DNA replication and genomic maintenance
- Place of Presentation
  Cold Spring Harbor, NY, USA
- Data Source
  KAKENHI-PROJECT-21657045
[Presentation] Possible roles of RNA in origin selection through two distinct mechanisms involving direct interactions of RNA with DNA, a transcription factor and human origin recognition complex2011
- Author(s)
  Shou Waga
- Organizer
  Cold Spring Harbor Laboratory Meeting for eukaryotic DNA replication and genomic maintenance
- Place of Presentation
  Cold Spring Harbor, NY(USA)
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-21657045
[Presentation] Possible involvement of RNA in recruiting the origin recognition complex to the viral and cellular replication origins.2010
- Author(s)
  和賀祥
- Organizer
  第33回日本分子生物学会年会、第83回日本生化学会大会合同大会(ワークショップ)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21657045
[Presentation] EBウイルス複製開始点oriPにおける複製開始複合体形成へのRNAの関与2009
- Author(s)
  和賀祥
- Organizer
  第82回日本生化学会大会シンポジウム
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21657045
[Presentation] Possible direct involvement of RNA regulating the function and establishment of metazoan replication origins2009
- Author(s)
  Shou Waga
- Organizer
  Switzerland-Japan joint meeting on the molecular mechanisms regulating "Chromosome dynamics and genomic stability"
- Place of Presentation
  Switzerland
- Data Source
  KAKENHI-PROJECT-21657045
[Presentation] Possible direct involvement of RNA regulating the function and establishment of metazoan replication origins2009
- Author(s)
  Shou Waga
- Organizer
  Switzerland-Japan joint meeting on the molecular mechanisms regulating "Chromo-some dynamics and genomic stability"
- Place of Presentation
  Villars-sur-Ollons, Switzerland
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-20055010
[Presentation] EBウイルス複製開始点oriPにおける複製開始複合体形成へのRNAの関与2009
- Author(s)
  和賀祥
- Organizer
  第82回日本生化学会大会シンポジウム
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20055010
[Presentation] A chromatin remodeler SNF2H is involved in pre-RC formation and Cdt1-induced checkpoint activation2009
- Author(s)
  Sugimoto, N., Waga, S., Kiyono, T. & Fujita, M.
- Organizer
  Keystone Symposia "Telomere Biology and DNA Repair"
- Place of Presentation
  Ashmore, Queensland, Australia
- Data Source
  KAKENHI-PROJECT-21370084
[Presentation] EBウイルス複製開始点oriPにおける複製開始複合体形成へのRNAの関与2009
- Author(s)
  和賀祥
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-21657045
[Presentation] RNA結合因子およびRNAの真核生物DNA複製開始への関与の可能性2008
- Author(s)
  和賀祥
- Organizer
  第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20055010
[Presentation] EBNA1 regulates ORC binding to oriP plasmids in vitro2007
- Author(s)
  和賀祥
- Organizer
  2007 Cold Spring Harbor Laboratory Meeting on Eukaryotic DNA Replication
- Place of Presentation
  米国コールドスプリングハーバー
- Year and Date
  2007-09-07
- Data Source
  KAKENHI-PROJECT-17013054
[Presentation] ヒトORCが認識するグアニン四重鎖モチーフの特異性に関する検討
- Author(s)
  保科祥子、和賀　祥
- Organizer
  第３７回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24570200
[Presentation] Further characterization of the binding of human ORC to G-quadruplex-formable RNA and singe-stranded DNA
- Author(s)
  Shou Waga
- Organizer
  The 9th 3R Symposium
- Place of Presentation
  静岡県御殿場市・御殿場高原ホテル
- Year and Date
  2014-11-17 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-24570200
[Presentation] ヒトORC1のG-rich RNA/一本鎖DNA結合に関わる新規結合ドメインの解析
- Author(s)
  寺西帆奈美、太田黒恵美、由良　敬、和賀　祥
- Organizer
  第３７回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24570200
[Presentation] G-rich RNA binding activity of human ORC possibly implicated in replication origin establishment
- Author(s)
  Shou Waga
- Organizer
  The 8th 3R Symposium
- Place of Presentation
  兵庫県淡路夢舞台
- Data Source
  KAKENHI-PROJECT-24570200

1. FUJITA Masatoshi (30270713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. KATAHIRA Masato (70211844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YURA Kei (50252226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 杉野明雄 (90231737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 川崎泰生 (30243257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 岡部勝 (30089875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 関丘 (40271118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 奥野友紀子 (00372524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

WAGA Shou 和賀 祥

和賀 祥 ワガ シヨウ

Research Projects

Research Products

Co-Researchers

The roles of the G-quadruplex-binding activity of human ORC in replication origin establishmentPrincipal Investigator

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Analysis of the structure and function of the RNA bound by human ORCPrincipal Investigator

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Analysis of GRWD1, a novel histone-binding protein involved in chromosomal replication initiation and segregation

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A novel role of RNA in the function at the replication origins in animal cellsPrincipal Investigator

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宿主と連携したEBウイルスDNA複製開始機構の解明と人工複製開始点構築への応用Principal Investigator

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真核生物の染色体複製における複製フォークの機能とその制御Principal Investigator

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真核生物染色体DNA複製フォークの分子ダイナミズム

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真核生物複製フォークの染色体複製およびゲノム安定性維持における役割Principal Investigator

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Functions of the Bloom syndrome gene product and the mechanism of genome instabilityPrincipal Investigator

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[Book] 細胞核の分子生物学-クロマチン・染色体・核構造-(水野重樹編)2005

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[Journal Article] Regulation of the Rev1-Pol zeta complex during bypass of a DNA interstrand crosslink2015

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[Journal Article] Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA.2013

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[Journal Article] Continued primer synthesis at stalled replication forks contributes to checkpoint activation2010

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[Journal Article] Redundant and differential regulation of multiple licensing factors ensures prevention of rereplication in normal human cells2009

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WAGA Shou 和賀祥

和賀祥ワガシヨウ