Takihara Yoshihiro 瀧原義宏

… Alternative Names

TAKIHARA Yoshihiro 瀧原義宏

滝原義宏タキハラヨシヒロ

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Researcher Number	60226967
Other IDs
External Links
Affiliation (Current)	2025: 広島大学, 原爆放射線医科学研究所, 名誉教授
Affiliation (based on the past Project Information) *help	2017 – 2018: 広島大学, 原爆放射線医科学研究所, 名誉教授 2003 – 2016: 広島大学, 原爆放射線医科学研究所, 教授 2001: 大阪府立成人病センター, 研究所・生化学部門・総括研究員, 部長 2001: 大阪府立成人病センター研究所, 生化学部門, 総括研究員 1994 – 2000: Res.Inst.for Microbial Diseases, Osaka University, 微生物病研究所, 助教授 1990 – 1993: 大阪大学, 微生物病研究所, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / General medical chemistry / General anatomy (including histology/embryology) / Biological Sciences / Hematology / Pathological medical chemistry / Risk sciences of radiation and chemicals / Laboratory animal science / General anatomy (including Histology/Embryology) / Hematology … More Except Principal Investigator … More Pathological medical chemistry / General medical chemistry / Regenerative medicine / Stem cell biology and medical science / Developmental biology / Hematology Less
Keywords	Principal Investigator Geminin / 造血幹細胞 / ポリコーム遺伝子群 / 自己複製 / ポリコーム複合体1 / 幹細胞 / Cdt1 / ポリコーム複合体 / Hoxb4 / 分化 … More / レトロウイルスベクター / 分子基盤 / DNA複製ライセンス化 / 幹細胞性 / ノックアウトマウス / rae28遺伝子 / 14-3-3 / F9 / 維持 / 心臓発生 / 心筋 / 心臓幹細胞 / Hoxa9 / 再生医学 / 造血幹細胞移植療法 / E3ユビキチンリガーゼ / 遺伝子改変マウス / 増幅 / DNA複製開始制御 / DNA複製制御 / ポリホメオティック遺伝子 / 遺伝子発現維持機構 / 低線量被ばく / 低線量率放射線被ばく / 多分化能 / 長期骨髄再構築能 / 低線量放射線被ばく / 心筋分裂 / 細胞周期 / retrovirus vector / genetically engineered mice / molecular basis / stemness / stem cells / Polycomb-group genes / 成体幹細胞 / 未分化造血細胞 / 拡張型心筋症 / rae28 / 染色体高次構造 / 遺伝子発現維持 / 心臓 / 発生 / knockout mouse / polyhomeotic / retinoic acid / ポリホメオティックタンパク質 / レケノイン酸 / レチノイン酸 / 心筋維持 / 組織形成 / 細胞分化 / ES細胞 / iPS細胞 / iPS 細胞 / 造血幹細胞移植学 / 活性操作 / HOXB4 / 慢性骨髄性白血病 / 白血病幹細胞 / 再生医療 / Cdtl / 幹細胞システム / B前駆細胞型急性リンパ性白血病 / rae2 / レトロウイルス / 小児B細胞白血病 / B細胞分化 / 造血前駆細胞 / Scmhl遺伝子 / 神経堤細胞 / Hox遺伝群 / 先天性心疾患 / CATCH22症候群 / ポリコ-ム遺伝子群 / F9細胞 … More Except Principal Investigator 造血幹細胞 / rae28遺伝子 / Geminin / 再生医学 / ノックアウトマウス / neural crest / rae28 / bmil / CATCH22症候群 / ポリホメオティック遺伝子 / 遺伝子標的組み込み / Hox / 自己複製 / ユビキチン化 / cre-loxP / rae28 gene / ANF / Hand1 / Nkx2.5 / Hox遺伝子 / 疾患モデル / polyhomeotic / MHC class I / segment specification / Polycomb group / protein interactions / 神経堤細胞 / トランスサイレチン / 胚性幹細胞 / ポリコーム / 細胞周期 / ポリコーム複合体 / 細胞増殖 / サイトカイン / LD78 / polycomb / transgenic mice / transcriptional factor / 遺伝子導入動物 / 転写因子 / congenital heart disease / CATCH22 syndorme / Nkx2.5 gene / Hox gene / knockout mouse / disease model mice / 先天性心疾患 / 神経堤 / retrovirus / maintenance / gene expression pattern / Hoxb3 gene / hematopoietic stem cell / Scmhl gene / Polycomb group of genes / Scmhl遺伝子 / レトロウイルス / 遺伝子発現維持 / Hoxb3遺伝子 / Scmh1遺伝子 / ポリコーム遺伝子群 / bmi-1遺伝子 / M33遺伝子 / Polycomb遺伝子 / polyhomeotic遺伝子 / Pc-G遺伝子群 / Polycomb / bmi1 / M33 / Pc-G遺伝子 / early mouse embryo / RA-inducible genes / gene family / GPI-anchor / glycoprotein / cell surface protein / F9 cells / Whole-mount in situ hybridization / Zoo blot / 初期胚 / レチノイン酸 / 遺伝子ファミリー / GPIアンカー / 糖タンパク質 / 膜タンパク質 / F9細胞 / polyomeotic / ファロ-の四徴 / 臓器形成不全 / ショウジョウバエ / 臓器形成制御 / ral28遺伝子 / 微小変異 / 胚性腫瘍細胞 / ジーンターゲティング / Replacement type vector / Thyroid hormone / RBP / Retinol / TTR-deficient mouse / Transthyretin / FAP / ES / 血清アミロイドP成分 / アミロイド / 甲状腺ホルモン / レチノール結合タンパク質 / レチノール / ビタミンA / 置換ベクター / ES細胞 / Gene Expression / mMDH / cMDH / mAspAT / cAspAT / Isoenzyme / Malate-aspartate Shuttle / リンゴ酸脱水素酵素 / トランスアミナ-ゼ / アスパラギン酸・リンゴ酸シャトル / 細胞質 / マウス / ミトコンドリア / GRE配列 / アスバラギン酸ーーリンゴ酸シャトル / 遺伝子発現 / ミトコンドリア型MDH遺伝子 / 細胞質型MDH遺伝子 / ミトコンドリア型AspAT遺伝子 / 細胞質型AspAT遺伝子 / アイソザイム / アスパラギン酸ーリンゴ酸シャトル / Hereditary diseases / Amyloidosis / Prealbumin / Chimeric mouse / Mouse model for human diseases / Embryonic stem cell / Homologous recombination / Gene targeting / 遺伝性疾患 / アミロイド-シス / プレアルブミン / キメラマウス / 疾患モデルマウス / 相同DNA間組換え / 細胞分化 / 幹細胞生物学 / Hoxa9/Hoxb4 / DMA複製制御 / DNA複製制御 / 発生・分化 / E3ユビキチンリガーゼ / HOXB4 / survivin / MDR / Survivin / BMI-1 / 突然変異 / 発生工学 / 分子遺伝学 / 先天性奇形 / 形態形成 / 大血管 / 心臓 / 発現誘導 / 走化性 / 炎症 / AT744 / Actー2 / 偽遺伝子 / プロモ-タ- / K562 / Jurkat / 発現調節 Less

Molecular and cellular analyses of hematopoietic stem cell damage induced by low dose-rate irradiationPrincipal Investigator
- Principal Investigator
  
  Takihara Yoshihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Hiroshima University
Detection of cell-cycling cardiac muscle cells by visualizing Geminin, and regeneration of cardiac muscle cellsPrincipal Investigator
- Principal Investigator
  
  Takihara Yoshihiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Hiroshima University
Basic research on regulatory system for self-renewal and differentiation of hematopoietic stem cells for the purpose of future application to regenerative medicine
- Principal Investigator
  
  YASUNAGA Shin'ichiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Regenerative medicine
- Research Institution
  Fukuoka University
  Hiroshima University
造血幹細胞の自己複製と分化の誘導を掛け分ける分子基盤Principal Investigator
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
Molecular role for Geminin in maintaining cardiac musclesPrincipal Investigator
- Principal Investigator
  
  TAKIHARA Yoshihiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Hiroshima University
造血幹細胞の自己複製と分化の誘導を掛け分ける分子基盤Principal Investigator
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
Analysis of regulatory mechanism for activity of hematopoietic stem cell mediated by regulation of Geminin protein
- Principal Investigator
  
  YASUNAGA Shin'ichiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Regenerative medicine
- Research Institution
  Hiroshima University
Detection and functional analysis of cardiac stem cellsPrincipal Investigator
- Principal Investigator
  
  TAKIHARA Yoshihiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Hiroshima University
Induction of hematopoietic stemcells from iPS cells and the molecular basis in the inductionPrincipal Investigator
- Principal Investigator
  
  TAKIHARA Yoshihiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University
Analysis of Hematopoietic stem cell regulation through Polycomb-group complex 1
- Principal Investigator
  
  OHTSUBO Motoaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Stem cell biology and medical science
- Research Institution
  Beppu University
  Hiroshima University
造血幹細胞の活性を支持するGemininの分子制御機構の解析Principal Investigator
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
Drug-resistant genes downstream of Polycomb group genes in leukemia stem cells
- Principal Investigator
  
  MIHARA Keichiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University
Analysis of hematopoietic stem cell regulation through Geminin ubiquitination
- Principal Investigator
  
  YASUNAGA Shin'ichiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Stem cell biology and medical science
- Research Institution
  Hiroshima University
Gemininを用いて造血幹細胞を増幅するための理論基盤の確立Principal Investigator
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University
がん幹細胞の活性制御におけるDNA複製ライセンス化の役割Principal Investigator
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
ポリコーム複合体によるDNA複製ライセンス化制御の造血幹細胞における役割Principal Investigator
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
ES細胞より造血幹細胞をex vivoで誘導する試みPrincipal Investigator
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Hiroshima University
Role of Polycomb-group genes in adult stem cells and their expansionPrincipal Investigator
- Principal Investigator
  
  TAKIHARA Yoshihiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  HIROSHIMA UNIVERSITY
ポリコーム遺伝子群による造血幹細胞の自己複製制御機構の研究Principal Investigator
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
ポリコーム遺伝子群を用いた造血幹細胞増幅の試みPrincipal Investigator
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Hiroshima University
ポリコーム遺伝子群による染色高次体構造を介した転写制御と白血病Principal Investigator
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
心大血管発生の分子機構と先天性疾患のメカニズム
- Principal Investigator
  
  三浦直行
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Hamamatsu University School of Medicine
ポリコーム遺伝子群欠損マウスを用いた心臓発生維持と造血幹細胞の制御機構の研究Principal Investigator
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
  Osaka University
ポリコーム遺伝子群rae28による造血制御と白血病Principal Investigator
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Osaka University
Gene Regulation in Cardiac Development
- Principal Investigator
  
  MIWA Takeshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Osaka University
マウスポリコーム遺伝子群による造血の維持と制御の分子機構の研究Principal Investigator
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Regulation of organogenesis and hematopoiesis in development
- Principal Investigator
  
  SHIMADA Kazunori
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
Study of CATCH22 syndorme using disease model mice
- Principal Investigator
  
  SHIMADA Kazunori
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
細胞分化の新しい制御機構の分子レベル及び個体レベルでの解析Principal Investigator
- Principal Investigator
  
  瀧原義宏
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
REGULATION OF MORPHOGENESIS IN EARLY MOUSE DEVELOPMENT
- Principal Investigator
  
  SHIMADA Kazunori
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
GENERATION OF MOUSE MODELS FOR HUMAN GENETIC DISEASESTHROUGH GENE TARGETING
- Principal Investigator
  
  SHIMADA Kazunori
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
Characterization of Rae-1, early embryo-specific membrane protein
- Principal Investigator
  
  NOMURA Midori
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Osaka University
Molecular mechanisms of retinoic acid-mediated control of cellular proliferation and differentiationPrincipal Investigator
- Principal Investigator
  
  TAKIHARA Yoshihiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
Use of embryonic stem cells to introduce mutations into mice
- Principal Investigator
  
  SHIMADA Kazunori
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Research Institute for Microbial Diseases, Osaka University
細胞増殖を制御する新しいサイトカインLD78α、β、γの遺伝子構造と作用機構の研究
- Principal Investigator
  
  島田和典
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka University
細胞増殖に関与する新しいサイトカインLD78の分子生物学的研究
- Principal Investigator
  
  SHINADA Kazunori
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Osaka University
Use of embryonic stem cell system to construct mouse model for human diseases
- Principal Investigator
  
  SHINADA Kazunori
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Osaka University
  Kumamoto University
Regulatory expression of the mitochondrial and cytosolic isoenzyme genes participating in the malate-aspartate shuttle
- Principal Investigator
  
  SHIMADA Kazunori
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
  Kumamoto University

[Book] Etiology and morphogenesis of congenital heart disease2016
- Author(s)
  Shirai, M., Takihara, Y., Morisaki, T.
- Total Pages
  383
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15K15018
[Book] 血液フロンティア・がん幹細胞研究の新たな展開・幹細胞における細胞周期制御2012
- Author(s)
  瀧原義宏、安永晋一郎、大野芳典、大坪素秋
- Total Pages
  11
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-21602004
[Book] 血液フロンティア・がん幹細胞研究の新たな展開・幹細胞における細胞周期制御2012
- Author(s)
  瀧原義宏,安永晋一郎,大野芳典,大坪素秋
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-21602004
[Book] 「細胞周期のフロンティア」細胞分化と増殖制御2010
- Author(s)
  瀧原義宏
- Publisher
  共立出版(印刷中)
- Data Source
  KAKENHI-PROJECT-20058025
[Book] 細胞周期フロンティア2010
- Author(s)
  瀧原義宏
- Total Pages
  252
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-22390195
[Book] 再生医療教科書シリーズ「幹細胞のシグナル伝達 Hox/Polycomb」2005
- Author(s)
  瀧原義宏
- Publisher
  コロナ社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390080
[Book] 再生医療教科書シリーズ「幹細胞のシグナル伝達 Hox/Polycomb」2005
- Author(s)
  瀧原義宏
- Publisher
  コロナ社
- Data Source
  KAKENHI-PROJECT-17045024
[Book] Annual Review 血液 20052005
- Author(s)
  瀧原義宏
- Data Source
  KAKENHI-PROJECT-16390080
[Book] 再生医療教科書シリーズ「幹細胞のシグナル伝達 Hox/Polycomb」2005
- Author(s)
  瀧原義宏
- Publisher
  コロナ社
- Data Source
  KAKENHI-PROJECT-17659084
[Book] 再生医療教科書シリーズ「幹細胞のシグナル伝達 Hox/Polycomb」2005
- Author(s)
  瀧原義宏
- Publisher
  コロナ社
- Data Source
  KAKENHI-PROJECT-16390080
[Journal Article] BMI1 controls transit amplification in chondrogenesis by preventing replication and transcription fork collision.2019
- Author(s)
  Spaapen F, Eijssen L, Welting T, Prickaerts P, Salvaing J, Dahlmans V, Surtel D A M, Kruitz F, Kuijer R, Takihara Y, Wouters B G, Vidal M, Voncken J.W.
- Journal Title
  
  Epigenomes
  
  Volume: 印刷中
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02955
[Journal Article] A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells2018
- Author(s)
  Sumide Keisuke、Matsuoka Yoshikazu、Kawamura Hiroshi、Nakatsuka Ryusuke、Fujioka Tatsuya、Asano Hiroaki、Takihara Yoshihiro、Sonoda Yoshiaki
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 2202-2202
- DOI
  10.1038/s41467-018-04441-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09962, KAKENHI-PROJECT-16H02955
[Journal Article] A revised map for the commitment of human CD34-negative hematopoietic stem cells.2018
- Author(s)
  Sumide, K., Matsuoka, Y., Kawamura, H., Nakatsuka, T., Fujioka, T., Asano, H., Takihara, Y., Sonoda, Y.
- Journal Title
  
  Nature Communications
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02955
[Journal Article] PRC1 prevents replication stress during chondrogenic transit amplification2017
- Author(s)
  Spaapen, F., Eijssen, L.M., Adriaens, M.E., Welting, T.J., Prickaerts, P., Salvaing, J., Dahlmans, V.E.H., Surtel, D.A.M., Kruitz, F., Kuijer, R., Takihara, Y., Marks, H., Stunnenberg, H.G., Wouters, B.G., Vidal, M., Voncken, J.W.
- Journal Title
  
  Epigenomes
  
  Volume: 1(3) Issue: 3 Pages: 22-22
- DOI
  10.3390/epigenomes1030022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02955
[Journal Article] 骨髄の組織反応2017
- Author(s)
  大野　芳典、竹立　恭子、白須　直人、安永　晋一郎、瀧原　義宏
- Journal Title
  
  放射線生物研究
  
  Volume: 52(4) Pages: 336-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02955
[Journal Article] Manipulation of cell cycle and chromatin configuration by means of cell-penetrating Geminin.2016
- Author(s)
  Ohno Y., Suzuki-Takedachi K., Yasunaga S., Kurogi T., Santo M., Masuhiro Y., Hanazawa S., Ohtsubo M., Naka K. & Takihara Y.
- Journal Title
  
  PLoS ONE
  
  Volume: 11(5) Issue: 5 Pages: 1-14
- DOI
  10.1371/journal.pone.0155558
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26501004, KAKENHI-PROJECT-15K15018
[Journal Article] Role of Geminin in cell fate determination of hematopoietic stem cells (HSCs)2016
- Author(s)
  YASUNAGA, S., OHNO, Y., SHIRASU, N., ZHANG, B., SUZUKI-TAKEDACHI, K., OHTSUBO, M. & TAKIHARA, Y.
- Journal Title
  
  Int J Hematol
  
  Volume: 104 Issue: 3 Pages: 324-9
- DOI
  10.1007/s12185-016-2060-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460664, KAKENHI-PROJECT-26501004
[Journal Article] Significance of ACADM mutations identified from newborn screening of MCAD deficiency in Japan2016
- Author(s)
  Keiichi Hara, Go Tajima, Satoshi Okada, Miyuki Tsumura, Reiko Kagawa, Kenichiro Shirao, Yoshinori Ohno, Shin'ichiro Yasunaga, Motoaki Ohtsubo, Ikue Hata, Nobuo Sakura, Yosuke Shigematsu, Yoshihiro Takihara, Masao Kobayashi
- Journal Title
  
  Molecular Genetics and Metabolism
  
  Volume: 118 Issue: 1 Pages: 9-14
- DOI
  10.1016/j.ymgme.2015.12.011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461526, KAKENHI-PROJECT-26501004, KAKENHI-PROJECT-15K21189
[Journal Article] MK3 modulation affects BMI1-dependent and independent cell cycle check-points2015
- Author(s)
  Prickaerts, P., Niessen, H. E. C., Dahlmans, V. E. H., Salvaing, J., Vanhove, J., Spaapen, F., Geijselaers, C., Partouns, I., Bartels, S. J. J., Neumann, D., Speel, E. J., Takihara, Y., Wouters, B. G., Voncken, J. W.
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 4 Pages: e0118840-e0118840
- DOI
  10.1371/journal.pone.0118840
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25118717
[Journal Article] Mosaicism of an ELANE mutation in an asymptomatic mother in a familial case of cyclic neutropenia.2015
- Author(s)
  Hirata O, Okada S, Ttsumura M, Karakawa S, Matsumura I, Kimura Y, Mihara T, Yasunaga S, Takihara Y, Ohara O, Kobayashi M
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 2015 Issue: 5 Pages: 1-5
- DOI
  10.1007/s10875-015-0165-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293231, KAKENHI-PROJECT-15K09461, KAKENHI-PROJECT-26501004, KAKENHI-PROJECT-15K21189, KAKENHI-PROJECT-26670501, KAKENHI-PROJECT-25713039
[Journal Article] Gemininによる白血病幹細胞の制御2015
- Author(s)
  安永晋一郎、大野芳典、瀧原義宏
- Journal Title
  
  日本臨床
  
  Volume: 73(5) Pages: 800-805
- Data Source
  KAKENHI-PROJECT-26501004
[Journal Article] Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis.2014
- Author(s)
  Mizoguchi Y, Tsumura M, Okada S, Hirata O, Minegishi S, Imai K, Hyakuna N, Muramatsu H, Kojima S, Ozaki Y, Imai T, Takeda S, Okazaki T, Ito T, Yasunaga S, Takihara Y, Bryant VL, Kong XF, Cypowyj S, Boisson-Dupuis S, Puel A, Casanova JL, Morio T, Kobayashi M.
- Journal Title
  
  J. Leukoc. Biol.
  
  Volume: 95 Issue: 4 Pages: 667-76
- DOI
  10.1189/jlb.0513250
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390270, KAKENHI-PROJECT-23618008, KAKENHI-PUBLICLY-25118717, KAKENHI-PUBLICLY-25130708, KAKENHI-PROJECT-25293231, KAKENHI-PROJECT-25293232, KAKENHI-PROJECT-25713039, KAKENHI-PROJECT-25870468, KAKENHI-PROJECT-26501004, KAKENHI-PROJECT-26670501, KAKENHI-PROJECT-26670502
[Journal Article] Transcription of the Geminin gene is regulated by a negative-feedback loop.2014
- Author(s)
  Ohno, Y., Saeki, K., Yasunaga, S., Kurogi. T., Suzuki-Takedachi, K., Shirai, M., Mihara K., Yoshida, K., Voncken J. W, Ohtsubo, M. & Takihara Y.
- Journal Title
  
  Mol. Biol. Cel
  
  Volume: 25(8) Issue: 8 Pages: 1374-1383
- DOI
  10.1091/mbc.e13-09-0534
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23618008, KAKENHI-PROJECT-24591595, KAKENHI-PROJECT-24790976, KAKENHI-PUBLICLY-25118717, KAKENHI-PUBLICLY-25130708, KAKENHI-PROJECT-25670096, KAKENHI-PROJECT-26501004
[Journal Article] Heterozygosity for the Y701C STAT1 mutation in a multiplex kindred with multifocal osteomyelitis.2013
- Author(s)
  Hirata, O., Okada, S., Tsumura, M., Kagawa, R., Miki, M., Kawaguchi, H., Nakamura, K., Boisson-Dupuis, S., Casanova, J.-L., Takihara, Y., Kobayashi, M.
- Journal Title
  
  Haematologica
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] Aurora-A controls pre-replicative complex formation and DNA replication by promoting the stabilization of geminin in mitosis2013
- Author(s)
  Tsunematsu, T., Takihara, Y., Ishimura, N., Pagano, M., Takata, T., Kudo, Y.
- Journal Title
  
  Nature Commun.
  
  Volume: 4 Pages: 1885-1885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659096
[Journal Article] Hoxa9 transduction induces mouse hematopoietic stem and progenitor cell activity through direct down-regulation of Geminin.2013
- Author(s)
  Ohno, Y., Yasunaga, S., Janmohamed, S., Ohtubo, M., Mihara, K., Iscove, N., Takihara, Y.
- Journal Title
  
  PLoS ONE
  
  Volume: 8(1) Issue: 1 Pages: e53161-e53161
- DOI
  10.1371/journal.pone.0053161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195, KAKENHI-PROJECT-23618008, KAKENHI-PROJECT-23659096, KAKENHI-PROJECT-24790976, KAKENHI-PUBLICLY-25130708, KAKENHI-PUBLICLY-23118519, KAKENHI-PUBLICLY-23130511
[Journal Article] Scmh1 has E3 ubiquitin ligase activity for Geminin and histone H2A and regulates Geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4.2013
- Author(s)
  Yasunaga, S., Ohtsubo, M., Ohno, Y., Tanaka-Okamoto, M., Ishizaki, H., Shirai, M., Mihara, K., Brock, W. H., Miyoshi, J., Takihara, Y.
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 33 Pages: 644-660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] Scmh1 has E3 ubiquitin ligase activity for Geminin and histone H2A and regulates Geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb42013
- Author(s)
  Yasunaga, S., Ohtsubo, M., Ohno, Y., Tanaka-Okamoto, M., Ishizaki, H., Shirai, M., Mihara, K., Brock, W. H., Miyoshi, J., Takihara, Y.
- Journal Title
  
  Mol. Cell. Biol
  
  Volume: 33 Pages: 644-660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659096
[Journal Article] MK3 controls Polycomb-target gene expression via negative feedback on ERK.2013
- Author(s)
  Prickaerts, P.
- Journal Title
  
  Epigenetics Chromatin
  
  Volume: 5 Issue: 1 Pages: 12-12
- DOI
  10.1186/1756-8935-5-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195, KAKENHI-PROJECT-23659096, KAKENHI-PUBLICLY-23118519
[Journal Article] Aurora-A controls pre-replicative complex formation and DNA replication by promoting the stabilization of geminin in mitosis.2013
- Author(s)
  Tsunematsu, T., Takihara, Y., Ishimura, N., Pagano, M., Takata, T., Kudo, Y.
- Journal Title
  
  Nature Commun.
  
  Volume: 4 Pages: 1885-1885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] Scmh1 has E3 ubiquitin ligase activity for Geminin and histone H2A and regulates Geminin stability directly or indirectly via transcription repression of Hoxa9 and Hoxb42013
- Author(s)
  Yasunaga, S., Ohtsubo, M., Ohno, Y., Saeki, K., Kurogi. T., Tanaka-Okamoto, M., Ishizaki, H., Shirai, M., Mihara, K., Brock, H. W., Miyoshi, J. & Takihara Y
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 33(4) Issue: 4 Pages: 644-660
- DOI
  10.1128/mcb.00974-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23618008, KAKENHI-PROJECT-23659096, KAKENHI-PROJECT-24591595, KAKENHI-PROJECT-24790976, KAKENHI-PUBLICLY-25130708, KAKENHI-PUBLICLY-23118519, KAKENHI-PUBLICLY-23130511
[Journal Article] MK3 controls Polycomb-target gene expression via negative feedback on ERK.2012
- Author(s)
  Prickaerts, P., Niessen, H., Mou-chel-Vielh, E., Dahlmans, V., Geijselaers, C., Adriaens, M., Spaapen, F., Takihara, Y., Rapp, U., Peronnet, F., Voncken, J.W.
- Journal Title
  
  Epigenetics Chromatin
  
  Volume: 5 Pages: 12-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] 幹細胞における細胞周期制御特集:がん幹細胞研究の新たな展開2012
- Author(s)
  瀧原義宏、安永晋一郎、大野芳典、大坪素秋
- Journal Title
  
  血液フロンティア(医薬ジャーナル社)
  
  Volume: 22 Pages: 33-43
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] T-cell immunotherapy with a chimeric receptor against CD38 is effective in eradicating refractory B-lymphoma cells overexpressing survivin induced by BMI-1.2012
- Author(s)
  Bhattacharyya, J., Mihara, K., Kitanaka, A., Yanagihara, K., Kubo, T. , Takei, Y., Kuroda, T., Kimura, A., Takihara, Y.
- Journal Title
  
  T-cell immunotherapy with a chimeric receptor against CD38 is effective in eradicating refractory B-lymphoma cells overexpressing survivin induced by BMI-1.
  
  Volume: 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation.2012
- Author(s)
  Ozaki, Y., Matsui, H., Asou, H., Nagamachi, A., Aki, D., Honda, H., Yasunaga, S., Takihara, Y., Yamamoto, T., Izumi, S., Ohsugi, M., Inaba, T.
- Journal Title
  
  Mol. Cell
  
  Volume: 47 Pages: 694-706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] oly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation2012
- Author(s)
  Ozaki, Yuko
- Journal Title
  
  Molecular Cell
  
  Volume: 47 Issue: 5 Pages: 694-706
- DOI
  10.1016/j.molcel.2012.06.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229006, KAKENHI-PROJECT-23390253, KAKENHI-PROJECT-23618008, KAKENHI-PLANNED-22118005, KAKENHI-PUBLICLY-23130511
[Journal Article] Overexpression of BMI-1 correlates with drug resistance in B-cell lymphoma cells through the stabilization of surviving expression2012
- Author(s)
  Bhattacharyya, J., Mihara, K., Ohtsubo, M., Yasunaga, S., Takei, Y., Yanagihara, K., Sakai, A., Hishi, M., Takihara, Y., Kimura, A.
- Journal Title
  
  Cancer Science
  
  Volume: 103(1) Pages: 34-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602004
[Journal Article] T-cell immunotherapy with a chimeric receptor against CD38 is effective in eliminating myeloma cells2012
- Author(s)
  Mihara, K., Bhattacharyya, J., Kitanaka, A., Yanagihara, K., Kubo, T., Takei, Y., Sakai, A., Asaoku, H., Takihara, Y., Kimura, A.
- Journal Title
  
  Leukemia
  
  Volume: 26 Pages: 365-367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] Dominant-negative STAT1 SH2 domain mutations in unrelated patients with Mendelian susceptibility to mycobacterial disease.2012
- Author(s)
  Tsumura M.
- Journal Title
  
  Human Mutation Human Mutation
  
  Volume: 33 Issue: 9 Pages: 1377-1387
- DOI
  10.1002/humu.22113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249042, KAKENHI-PROJECT-22591161, KAKENHI-PROJECT-23618008, KAKENHI-PROJECT-24659496, KAKENHI-PUBLICLY-23130511
[Journal Article] 幹細胞における細胞周期制御特集:がん幹細胞研究の新たな展開2012
- Author(s)
  瀧原義宏、安永晋一郎、大野芳典、大坪素秋
- Journal Title
  
  血液フロンティア(医薬ジャーナル社)
  
  Volume: 22 Pages: 33-43
- Data Source
  KAKENHI-PROJECT-23659096
[Journal Article] Dominant-negative STAT1 mutations in the SH2 domain predispose to mycobacterial diseases.2012
- Author(s)
  Tsumura, M., Okada, S., Sakai, H., Yasunaga, S., Ohtsubo, M., Murata, T., Obata, H., Yasumi, T., Kong, X., Abhyankar, A., Heike, T., Nakahata, T., Nishikomori, R., Al-Muhsen, S., Boisson-Dupuis, S., Casanova, J.-L., AlSherhri, M., ElGhazali, G., Takihara, Y., Kobayashi, M.
- Journal Title
  
  Hum. Mutat.
  
  Volume: 33 Pages: 1377-1387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] Overexpression of BMI-1 correlates with drug resistance in B-cell lymphoma cells through the stabilization of survivin expression2012
- Author(s)
  Bhattacharyya, J., Mihara, K., Ohtsubo, M., Yasunaga, S., Takei, Y., Yanagihara, Y., Sakai, A., Hoshi, M., Takihara, Y., Kimura, A.
- Journal Title
  
  Cancer Sci.
  
  Volume: 103(1) Issue: 1 Pages: 34-41
- DOI
  10.1111/j.1349-7006.2011.02121.x
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23130511, KAKENHI-PROJECT-23618008, KAKENHI-PROJECT-24590348
[Journal Article] Role for Geminin in sustaining the activity of hematopoietic stem cells.2011
- Author(s)
  Takihara, Y.
- Journal Title
  
  Cell Cycle
  
  Volume: 10 Pages: 561-562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] Decreased expression in nuclear factor-kB essential modulator due to a novel splice-site mutation causes X-linked ectodermal dysplasia with immune- deficiency2011
- Author(s)
  Karakawa, S., Okada, S., Tsumura, M., Mizoguchi, Y., Hara, K., Ohno, N., Yasunaga, S., Ohtsubo M., Kawai, T., Nishikimori, R., Sakaguchi, T., Hata, I., Sakura, N., Takihara, Y. & Kobayashi, M.
- Journal Title
  
  Clin. Immunol.
  
  Volume: 31(5) Issue: 5 Pages: 762-772
- DOI
  10.1007/s10875-011-9560-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23618008
[Journal Article] 造血幹細胞の守護神Geminin2011
- Author(s)
  瀧原義宏
- Journal Title
  
  原医研ニュース
  
  Volume: 2 Pages: 6-7
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] Role for Geminin in sustaining the activity of hematopoietic stem cells.2011
- Author(s)
  Takihara, Y.
- Journal Title
  
  Cell Cycle
  
  Volume: 10 Pages: 561-562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659096
[Journal Article] Decreased expression in nuclear factor-kB essential modulator due to a novel splice-site mutation causes X-linked ectodermal dysplasia with immunodeficiency2011
- Author(s)
  Karakawa, S., Okada, S., Tsumura, M., Mizoguchi, Y., Ohno, N., Yasunaga, S., Ohtsubo, M., Kawai, T., Nishikomori, R., Sakaguchi, T., Takihara, Y., Kobayashi, M.
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 31(5) Pages: 762-772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602004
[Journal Article] 造血幹細胞の守護神Geminin2011
- Author(s)
  瀧原義宏
- Journal Title
  
  原医研ニュース
  
  Volume: 2 Pages: 6-7
- Data Source
  KAKENHI-PROJECT-23659096
[Journal Article] Molecular pathogenesis of novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency.2010
- Author(s)
  Shirao, K., Okada, S., Tajima, G., Tsumura, M., Hara, K., Yasunaga, S., Ohtsubo M., Hata, I., Sakura, N., Shigematsu, Y., Takihara, Y., Kobayashi, M.
- Journal Title
  
  Hum. Genet. 127(6)
  
  Pages: 619-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610003
[Journal Article] Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential2010
- Author(s)
  Ohno, Y., Yasunaga, S., Ohtsubo, M., Mori, S., Tsumura, M., Okada, S., Ohta, T., Ohtani, K., Kobayashi, M., Takihara, Y.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 107 Pages: 21529-21534
- NAID
  40019027599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602004
[Journal Article] Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential.2010
- Author(s)
  Ohno, Y., Yasunaga, S., Ohtsubo, M., Mori, S., Tsumura, M., Okada, S., Ohta, T., Ohtani, K., Kobayashi, M., Takihara, Y.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 107 Pages: 21529-21534
- NAID
  40019027599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602004
[Journal Article] Molecular pathogenesis of a novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency.2010
- Author(s)
  Shirao, K., Okada, S., Tajima, G., Tsumura, M., Hara, K., Yasunaga, S., Ohtsubo, M., Hata, I., Sakura, N., Shigematsu, Y., Takihara, Y., Kobayashi, M.
- Journal Title
  
  Hum.Genet.
  
  Volume: 127(6) Pages: 619-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602004
[Journal Article] Synergistic and persistent effect of T-cell immunotherapy with anti-CD19 or anto-CD38 chimeric receptor in conjunction with rituximab on B-cell non-Hodgkin lymphoma.2010
- Author(s)
  Mihara, K., Yanagihara, K., Takigahira, M., Imai, C., Bhattacharyya, J., Kubo, T., Takei, Y., Yasunaga, S., Takihara, Y..Kimura, A.
- Journal Title
  
  Br.J.Haematol. 151(1)
  
  Pages: 37-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610003
[Journal Article] 細胞周期のフロンティア2010
- Author(s)
  瀧原義宏
- Journal Title
  
  細胞分化と増殖制御-造血幹細胞の活性支持におけるポリコーム複合体の機能蛋白質核酸酵素(共立出版)
  
  Pages: 230-235
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] HOXB4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with growth potential.2010
- Author(s)
  Ohno, Y., Yasunaga, S., Ohtsubo, M., Mori, S., Tsumura, M., Okada, S., Ohta, T., Ohtani, K., Kobayashi, M., Takihara, Y.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 107 Pages: 21529-21534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] Synergistic and persistent effect of T-cell immunotherapy with anti-CD19 or anti-CD38 chimeric receptor in conjunction with rituximab on B-cell non-Hodgkin lymphoma.2010
- Author(s)
  Mihara K, Yanagihara K, Takigahira M, Kitanaka A, Imai C, Bhattacharyya J, Kubo T, Takei Y, Yasunaga S, Takihara Y, Kimura A.
- Journal Title
  
  Br J Haematol. 151(1)
  
  Pages: 37-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591128
[Journal Article] Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential.2010
- Author(s)
  Ohno, Y., Yasunaga, S., Ohtsubo, M., Mori, S., Tsumura, M., Okada, S., Ohta, T., Ohtani, K., Kobayashi, M., Takihara Y
- Journal Title
  
  Proc.Natl.Acad.Sci. 107(50)
  
  Pages: 21529-21534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610003
[Journal Article] Molecular pathogenesis of a novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency2010
- Author(s)
  Shirao, K., Okada, S., Tajima, G., Tsumura, M., Hara, K., Yasunaga, S., Ohtsubo, M., Hata, I., Sakura, N., Shigematsu, Y., Takihara, Y., Kobayashi, M.
- Journal Title
  
  Human Genetics
  
  Volume: 127(6) Pages: 619-628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21602004
[Journal Article] Synergistic and persistent effect of T-cell immunotherapy with anti-CD19 or anti-CD38 chimeric receptor in conjunction with rituximab on B-cell non-Hodgkin's lymphoma.2010
- Author(s)
  Mihara, K., Yanagihara, K., Takigahira, M., Kitanaka, A., Imai, C., Bhattachayya, J., Kubo, T., Takei, Y., Yasunaga, S., Takihara, Y., Kimura, A.
- Journal Title
  
  Br. J. Haematol.
  
  Volume: 151 Pages: 37-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390195
[Journal Article] BMI-1 expression is enhanced through transcriptional and posttranscriptional regulation during progression of chronic myeloid leukemia.2009
- Author(s)
  Bhattacharyya, J., Mihara, K., Yasunaga, S., Tanaka, H., Hoshi, M., Takihara, Y., Kimura, A.
- Journal Title
  
  Ann. Hematol. 88(4)
  
  Pages: 333-340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610003
[Journal Article] Cardiac infiltration in early-onset sarcoidosis associated with a novel heterozygous mutation, G481D, in CARD15.2009
- Author(s)
  Okada, S., Konishi, N., Tsumura, M., Shirao, K., Yasunaga, S., Sakai, H., Nishikomori, R., Takihara, Y., Kobayashi, M.
- Journal Title
  
  Rheumatology (Oxford) 48(6)
  
  Pages: 706-707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610003
[Journal Article] Gemininの制御と機能の多面性2009
- Author(s)
  瀧原義宏
- Journal Title
  
  細胞工学 128
  
  Pages: 29-33
- Data Source
  KAKENHI-PROJECT-20659152
[Journal Article] 造血幹細胞の維持へのユビキチンープロテオソーム系の関与2009
- Author(s)
  瀧原義宏
- Journal Title
  
  生体の科学 60
  
  Pages: 563-569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20058025
[Journal Article] Activated T-cell-mediated immunotherapy with a chimeric receptor against CD38 in B-cell non-Hodgkin lymphoma.2009
- Author(s)
  Mihara K, Yanagihara K, Takigahira M, Imai C, Kitanaka A, Takihara Y, Kimura A.
- Journal Title
  
  J Immunother. 32(7)
  
  Pages: 737-743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591128
[Journal Article] Gemininの制御と機能の多面性2009
- Author(s)
  瀧原義宏
- Journal Title
  
  細胞工学 128
  
  Pages: 29-33
- Data Source
  KAKENHI-PROJECT-20058025
[Journal Article] BMI-1 expression is enhanced through transcriptional and posttranscriptional regulation during the progression of chronic myeloid leukemia.2009
- Author(s)
  Bhattacharyya J, Mihara K, Yasunaga S, Tanaka H, Hoshi M, Takihara Y, Kimura A.
- Journal Title
  
  Ann Hematol. 88(4)
  
  Pages: 333-340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591128
[Journal Article] Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity.2008
- Author(s)
  Ohtsubo M., Yasunaga Y. & Takihara Y., et al.
- Journal Title
  
  Proc. Natl. Acad. Sci. 105
  
  Pages: 10396-10401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610003
[Journal Article] Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity.2008
- Author(s)
  Ohtsubo, M., Yasunaga, S., Ohno, Y., Tsumura, M., Okada, S., Ishikawa, N., Shirao, K., Kikuchi, A., Nishitani, H., Kobayashi, M., Takihara Y
- Journal Title
  
  Proc.Natl.Acad.Sci. 105(30)
  
  Pages: 10396-10401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20610003
[Journal Article] ポリコーム遺伝子群2007
- Author(s)
  瀧原義宏
- Journal Title
  
  造血器腫瘍アトラス (印刷中)
- Data Source
  KAKENHI-PROJECT-17045024
[Journal Article] ポリコーム遺伝子群2007
- Author(s)
  瀧原義宏
- Journal Title
  
  造血器腫瘍アトラス (印刷中)
- Data Source
  KAKENHI-PROJECT-18013036
[Journal Article] がん幹細胞の活性を支持するポリコーム遺伝子群の役割2007
- Author(s)
  瀧原義宏
- Journal Title
  
  Biotherapy (印刷中)
- Data Source
  KAKENHI-PROJECT-17045024
[Journal Article] がん幹細胞の活性を支持するポリコーム遺伝子群の役割2007
- Author(s)
  瀧原義宏
- Journal Title
  
  Biotherapy (印刷中)
- Data Source
  KAKENHI-PROJECT-18013036
[Journal Article] 白血病幹細胞研究の新展開2007
- Author(s)
  瀧原義宏
- Journal Title
  
  Front Wave in Hematology (印刷中)
- Data Source
  KAKENHI-PROJECT-17045024
[Journal Article] 白血病幹細胞研究の新展開2007
- Author(s)
  瀧原義宏
- Journal Title
  
  Front Wave in Hematology (印刷中)
- Data Source
  KAKENHI-PROJECT-18013036
[Journal Article] ポリコーム遺伝子群の分子機能と幹細胞制御 : 幹細胞を支持する分子基盤2006
- Author(s)
  瀧原義宏
- Journal Title
  
  医学のあゆみ 217
  
  Pages: 557-562
- Data Source
  KAKENHI-PROJECT-18013036
[Journal Article] ポリコーム遺伝子群の分子機能と幹細胞制御 : 幹細胞を支持する分子基盤2006
- Author(s)
  瀧原義宏
- Journal Title
  
  医学のあゆみ 217
  
  Pages: 557-562
- Data Source
  KAKENHI-PROJECT-17045024
[Journal Article] 幹細胞の活性を支持するポリコーム遺伝子群2006
- Author(s)
  瀧原義宏
- Journal Title
  
  放射線科学 49
  
  Pages: 353-360
- NAID
  40019062763
- Data Source
  KAKENHI-PROJECT-17045024
[Journal Article] 幹細胞の活性を支持するポリコーム遺伝子群2006
- Author(s)
  瀧原義宏
- Journal Title
  
  放射線科学 49
  
  Pages: 353-360
- NAID
  40019062763
- Data Source
  KAKENHI-PROJECT-18013036
[Journal Article] 造血幹細胞の自己複製機構2005
- Author(s)
  瀧原義宏
- Journal Title
  
  Annual Review 血液 2005
  
  Pages: 11-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390080
[Journal Article] 白血病は何時から治る病になったか? 〜造血幹細胞を用いた骨髄再生療法の現状と将来〜2005
- Author(s)
  瀧原義宏
- Journal Title
  
  原子力システムニュース 16
  
  Pages: 5-16
- Data Source
  KAKENHI-PROJECT-17045024
[Journal Article] 造血幹細胞の自己複製機構2005
- Author(s)
  瀧原義宏
- Journal Title
  
  Annual Review血液 2005
  
  Pages: 11-24
- Data Source
  KAKENHI-PROJECT-17659084
[Journal Article] Polycomb-group genes and hematopoietic stem cells2005
- Author(s)
  Takihara, Y.
- Journal Title
  
  J.Clin.Exp.Med., Hematological disorders-State of arts Ver.3, 3
  
  Pages: 52-58
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390080
[Journal Article] 白血病は何時から治る病になったか? 〜造血幹細胞を用いた骨髄再生療法の現状と将来〜2005
- Author(s)
  瀧原義宏
- Journal Title
  
  原子力システムニュース 16
  
  Pages: 5-16
- Data Source
  KAKENHI-PROJECT-17659084
[Journal Article] When did we get a cure for, leukemia? Cell therapy with hematopoietic stem cells and its future.2005
- Author(s)
  Takihara, Y.
- Journal Title
  
  Nuclear power system news 3
  
  Pages: 5-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390080
[Journal Article] Signal transductions in Stem cells ; Hox/Polycomb2005
- Author(s)
  Takihara, Y.
- Journal Title
  
  Textbook for Regenerative Medicine
  
  Pages: 228-238
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390080
[Journal Article] Self renewal system in hematopoietic stem cells2005
- Author(s)
  Takihara, Y., et al.
- Journal Title
  
  Annual Review Hematology 2005
  
  Pages: 11-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390080
[Journal Article] ポリコーム遺伝子群と造血幹細胞2005
- Author(s)
  瀧原義宏
- Journal Title
  
  医学のあゆみ「血液疾患 - state of arts Ver.3」 3
  
  Pages: 52-58
- Data Source
  KAKENHI-PROJECT-17659084
[Journal Article] 白血病は何時から治る病になったか? 〜造血幹細胞を用いた骨髄再生療法の現状と将来〜2005
- Author(s)
  瀧原義宏
- Journal Title
  
  原子力システムニュース 16
  
  Pages: 5-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390080
[Journal Article] ポリコーム遺伝子群と造血幹細胞2005
- Author(s)
  瀧原義宏
- Journal Title
  
  医学のあゆみ「血液疾患-state of arts Ver.3」 3
  
  Pages: 52-58
- Data Source
  KAKENHI-PROJECT-17045024
[Journal Article] 造血幹細胞の自己複製機構2005
- Author(s)
  瀧原義宏
- Journal Title
  
  Annual Review血液 2005
  
  Pages: 11-24
- Data Source
  KAKENHI-PROJECT-17045024
[Journal Article] ポリコーム遺伝子群と造血幹細胞2005
- Author(s)
  瀧原義宏
- Journal Title
  
  医学のあゆみ「血液疾患-state of arts Ver.3」 3
  
  Pages: 52-58
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390080
[Journal Article] 造血幹細胞の自己複製機構2005
- Author(s)
  瀧原義宏
- Journal Title
  
  Annual Review 血液 2005
  
  Pages: 11-24
- Data Source
  KAKENHI-PROJECT-15039239
[Journal Article] ポリコーム遺伝子群と造血幹細胞2005
- Author(s)
  瀧原義宏
- Journal Title
  
  医学のあゆみ「血液疾患-state of arts Ver.3」 3
  
  Pages: 52-58
- Data Source
  KAKENHI-PROJECT-16390080
[Journal Article] ポリコーム遺伝子群の機能2004
- Author(s)
  瀧原義宏
- Journal Title
  
  細胞工学 23
  
  Pages: 74-80
- Data Source
  KAKENHI-PROJECT-15039239
[Journal Article] ポリコーム遺伝子群の機能2004
- Author(s)
  瀧原義宏
- Journal Title
  
  細胞工学 23
  
  Pages: 74-80
- Data Source
  KAKENHI-PROJECT-16390080
[Presentation] 造血における低線量率放射線に対する分子応答2018
- Author(s)
  大野芳典, 竹立恭子, 山藤幹茂子, 郭芸, 菅野雅元、白須直人, 安永晋一郎, 大坪素秋, 瀧原義宏
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] 低線量率放射線が造血幹細胞活性に与える影響2018
- Author(s)
  大野芳典, 竹立恭子, 郭芸, 菅野雅元、白須直人, 安永晋一郎, 大坪素秋, 瀧原義宏
- Organizer
  中国地区放射線影響研究会
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] 幹細胞活性制御因子Gemininの白血病の病態制御における役割2018
- Author(s)
  大野芳典, 竹立恭子, 白須直人, 安永晋一郎, 大坪素秋, 瀧原義宏
- Organizer
  第22回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] Effect of low dose-rate irradiation on the hematopoietic stem cells.2018
- Author(s)
  大野芳典, 竹立恭子, 郭芸, 菅野雅元、白須直人, 安永晋一郎, 大坪素秋, 瀧原義宏
- Organizer
  第80回日本血液学会総会
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] 低線量率放射線による造血幹細胞の機能低下とその分子機序2018
- Author(s)
  大野芳典, 竹立恭子, 山藤幹茂子, 郭芸, 菅野雅元、白須直人, 安永晋一郎, 大坪素秋, 瀧原義宏
- Organizer
  第61回日本放射線影響学会大会
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] 低線量率放射線照射環境下における造血システムへの影響とその分子応答2017
- Author(s)
  大野芳典, 竹立恭子, 郭芸, 菅野雅元、白須直人, 安永晋一郎, 大坪素秋, 瀧原義宏
- Organizer
  第60回日本放射線影響学会学術集会
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] Molecular response for low dose-rate irradiation in the hematopoietic system2017
- Author(s)
  大野芳典, 竹立恭子, 郭芸, 菅野雅元, 白須直人, 安永晋一郎, 大坪素秋, 瀧原義宏
- Organizer
  第15回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] 低線量率放射線が造血に与える影響2017
- Author(s)
  大野芳典, 竹立恭子, 白須直人, 安永晋一郎, 大坪素秋, 瀧原義宏
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] 造血幹細胞の細胞周期制御と分化制御における分子機能2017
- Author(s)
  竹立恭子, 大野芳典, 白須直人, 安永晋一郎, 大坪素秋, 瀧原義宏
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] 膜透過型ペプチドを用いた幹細胞活性制御因子Gemininの発現制御法の開発2017
- Author(s)
  竹立恭子, 大野芳典, 白須直人, 安永晋一郎, 大坪素秋, 瀧原義宏
- Organizer
  第２１回バイオ治療法研究会学術集会
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] 低線量率放射線被ばくに対する造血システムの分子応答2017
- Author(s)
  大野芳典, 竹立恭子, 郭芸, 菅野雅元, 白須直人, 安永晋一郎, 大坪素秋, 瀧原義宏
- Organizer
  第5８回原爆後障害研究会
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] 造血幹細胞の細胞周期と分化を制御する中核因子Geminin2017
- Author(s)
  大野芳典, 竹立恭子, 白須直人, 安永晋一郎, 大坪素秋, 瀧原義宏
- Organizer
  第２１回バイオ治療法研究会学術集会
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] Molecular responses for low dose-rate irradiation in the hematopoietic stem cells.2017
- Author(s)
  大野芳典, 竹立恭子, 郭芸, 菅野雅元, 白須直人, 安永晋一郎, 大坪素秋, 瀧原義宏
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] Effect of low dose-rate irradiation on the hematopoietic stem cells2017
- Author(s)
  Ohno, Y., Shirasu, N., Suzuki-Takedachi, K., Santo, M., Guo, Y., Kanno, M., Yasunaga, S., Ohtsubo, M., Takihara, Y.
- Organizer
  The 1st International Symposium of the network-type Joint Usage/ Research Center for Radiation Disaster Medical Science
- Place of Presentation
  Hiroshima, Japan
- Year and Date
  2017-02-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] Effect of low dose-rate irradiation on the hematopoietic system.2017
- Author(s)
  Ohno Y. , Shirasu N., Suzuki-Takedachi K., Santo M.,Guo Y., Kanno M., Yasunaga S., Ohtsubo M. , Takihara Y.
- Organizer
  The 1st International Symposium of the network-type Joint Usage/Research Center for Radiation Disaster Medical Science
- Place of Presentation
  Hiroshima, Japan
- Year and Date
  2017-02-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] Low dose-rate irradiation specifically affects hematopoietic stem cells2016
- Author(s)
  Takihara, Y., Ohno, Y., Suzuki-Takedachi, K., Santo M., Yasunaga, S., Ohtsubo, M., Naka, K.
- Organizer
  45th Annual Scientific Meeting of the International Society of Experimental Hematology
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-08-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] Low dose-rate irradiation specifically affects hematopoietic stem cells.2016
- Author(s)
  Ohno, Y., Suzuki-Takedachi, K., Santo, M., Guo, Y., Kanno, M., Yasunaga, S., Ohtsubo, M., Naka, K., Takihara, Y.
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] マウス成体心臓におけるPolycomb repressive complex 1.5 (PRC1.5) の機能的解析2016
- Author(s)
  白井学、金美花、土持裕胤、大谷健太郎、瀧原義宏、森崎隆幸
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K15018
[Presentation] Effect of low dose-rate irradiation on the hematopoietic system.2016
- Author(s)
  Ohno Y., Suzuki-Takedachi K., , Santo M., Guo Y., Kanno, Yasunaga S., Ohtsubo M., Naka K., Takihara Y.
- Organizer
  The 14th Stem Cell Research Symposium
- Place of Presentation
  Awaji, Japan
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] A new strategy for manipulating expression and activity of Geminin could make it possible to regulate cell fates of HSCs.2016
- Author(s)
  Takihara Y., Ohno Y., Suzuki-Takedachi K., Santo M., Yasunaga S., Ohtsubo M., Naka K.
- Organizer
  ISEH (International Society for Experimental Hematology) 45th Annual Scientific Meeting
- Place of Presentation
  San Diego, U.S.A.
- Year and Date
  2016-08-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] 造血幹細胞の低線量率放射線被ばくに対する分子応答の解析2016
- Author(s)
  大野芳典、鈴木-竹立恭子、山藤幹茂子、郭芸、菅野雅元、白須直人、大坪素秋、仲一仁、安永晋一郎、瀧原義宏
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] 造血幹細胞の低線量率放射線被ばくに対する分子応答の解析2016
- Author(s)
  大野芳典、鈴木－竹立恭子、山藤幹茂子、郭芸、菅野雅元、白須直人、大坪素秋、仲一仁、安永晋一郎、瀧原義宏
- Organizer
  第３９回日本分子生物学年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] 造血システムに対する放射線被ばくの影響2016
- Author(s)
  瀧原義宏
- Organizer
  日本放射線影響学会第59回大会
- Place of Presentation
  広島
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] Effect of low dose-rate irradiation on the hematopoietic system.2016
- Author(s)
  Ohno, Y., Suzuki-Takedachi, K., Santo, M., Guo, Y., Kanno, M., Yasunaga, S., Ohtsubo, M., Naka, K., Takihara, Y.
- Organizer
  The 14th Stem Cell Research Symposium
- Place of Presentation
  Awaji, Japan
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-16H02955
[Presentation] Analysis of molecular role for Geminin in self-renewal and differentiation of HSCs.2015
- Author(s)
  Suzuki-Takedachi K.,Ohno Y., Kurogi T., Santo M., Yasunaga S., Ohtsubo M., Naka K., Takihara Y.
- Organizer
  The 77th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Kanazawa, Japan.
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] Manipulation of the Geminin activety by using cell-penetrating Geminin and its domein-specific mutants.2015
- Author(s)
  Ohno Y., Yasunaga S., Suzuki-Takedachi K., Kurogi T., Santo M., Ohtsubo M., Naka K., Takihara Y.
- Organizer
  The 13th Stem Cell Research Symposium
- Place of Presentation
  Tokyo, Japan.
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] 成体心臓におけるPcgf5(Polycomb ring finger 5)遺伝子の機能的解析2015
- Author(s)
  白井学、金美花、大谷健太郎、土持裕胤、瀧原義宏、森崎隆幸
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド　神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K15018
[Presentation] A new strategy for manipulating expression and activety of Geminin, a cell-fate determinant for HSCs.2015
- Author(s)
  Ohno Y., Suzuki-Takedachi K., Kurogi T., Santo M., Yasunaga S., Ohtsubo M., Naka K., Takihara Y.
- Organizer
  The 77th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Kanazawa, Japan.
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] DNA複製とクロマチンリモデリングを制御するCell-penetrating (CP-)Gemininの開発2015
- Author(s)
  竹立（鈴木）恭子、大野芳典、黒木利知、安永晋一郎、山藤幹茂子、舛廣善和、花澤重正、大坪素秋、仲一仁、瀧原義宏
- Organizer
  第３８回日本分子生物学会・第８８回日本生化学会合同年会（BMB２０１５）
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] Effects of low-dose irradiation on the hematopoietic system.2015
- Author(s)
  Yasunaga S., Ohno Y., Suzuki-Takedachi K., Kurogi T., Santo M., Ohtsubo M., Takihara Y.
- Organizer
  The 5th International Symposium of RIRBM, Hiroshima University
- Place of Presentation
  Hiroshima, Japan
- Year and Date
  2015-03-02
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] Identification and functional analysis of self-renewing hematopoietic stem cells by using Geminin-EYFP knock-in mice2014
- Author(s)
  Yasunaga, S., Ohno, S., Suzuki-Takedachi, K., Kurogi, T., Santo, M., Ohtsubo, M., Takihara, Y.
- Organizer
  The 12nd Stem Cell Research Symposium
- Place of Presentation
  福岡、九州大学医学部百年講堂
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PUBLICLY-25118717
[Presentation] Expression and molecular function of Geminin, which governs hematopoietic stem cell activity2013
- Author(s)
  Takihara Y., Yasunaga S., Ohno Y., Kurogi T., Suzuki-Takedachi K., Nakashima Y., Ohtsubo M.,
- Organizer
  第８６回日本生化学会大会
- Place of Presentation
  Yokohama, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-23618008
[Presentation] Negative feed-back loop regulates transcription of the Geminin gene, which governs HSC activity2013
- Author(s)
  Ohno Y., Yasunaga S., Kurogi T., Suzuki-Takedachi K., Nakashima Y., Ohtsubo M., Takihara Y.
- Organizer
  The 75th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-23618008
[Presentation] Molecular role for Geminin in switching self-renewal and differentiation of hematopoietic cells2013
- Author(s)
  Yasunaga S., Ohno Y., Kurogi T., Suzuki-Takedachi K., Nakashima Y., Ohtsubo M., Takihara Y.
- Organizer
  The 75th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-23618008
[Presentation] E2F-mediated transcriptional activation of the Geminin gene is under the regulation of a negative-feedback loop2013
- Author(s)
  Ohno Y., Saeki K., Yasunaga S., Shirai M., , Kurogi T., Nakashima Y., Ohtsubo M., Takihara Y.
- Organizer
  The 11th Stem Cell Research Symposium
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-23618008
[Presentation] Negative feed-back loop regulates E2F-mediated transcriptional activation of the Geminin gene2013
- Author(s)
  Kurogi T., Ohno Y., Yasunaga S., Suzuki-Takedachi K., Shirai M., Ohtsubo M., Takihara Y.
- Organizer
  The 36th Annual Meeting of the Molecular Biology of Japan
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-23618008
[Presentation] Visualization and functional analysis of Geminin, a candidate molecule governing self-renewal and cellular differentiation of hematopoietic stem cells2013
- Author(s)
  Yasunaga S., Ohno Y., Kurogi T., Saeki K., Nakashima Y., Ohtsubo M., Takihara Y.
- Organizer
  The 11th Stem Cell Research Symposium
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-23618008
[Presentation] Visualization and functional analysis of Geminin in the hematopoietic system2013
- Author(s)
  Takihara, Y.
- Organizer
  th annual meeting of Korean Society for Stem Cell Research
- Place of Presentation
  Seoul
- Invited
- Data Source
  KAKENHI-PUBLICLY-25118717
[Presentation] Visualization and functional dissection of Geminin, a molecule governing cellular proliferation and differentiation in hematopoietic stem cells2013
- Author(s)
  Takihara, Y.
- Organizer
  42nd annual scientific meeting of the international society for hematology and stem cells
- Place of Presentation
  Viena
- Data Source
  KAKENHI-PUBLICLY-25118717
[Presentation] Molecular analysis of a role for Geminin in regulating proliferation and differentiation of hematopoietic stem/progenitor cells by visualizing Geminin expression2013
- Author(s)
  Suzuki-Takedachi K., Yasunaga S., Ohno Y., Kurogi T., Ohtsubo M., Takihara Y.
- Organizer
  The 36th Annual Meeting of the Molecular Biology of Japan
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-23618008
[Presentation] Expression and molecular function of Geminin, which governs hematopoietic stem cell activity2013
- Author(s)
  Takihara, Y.
- Organizer
  第86回日本生化学会大会　インターナショナルセッション
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PUBLICLY-25118717
[Presentation] Scmh1 is required for maintaining hematopoietic homeostasis through the molecular network governing Geminin expression.2012
- Author(s)
  Ohno, Y., Yasunaga, S., Saeki, K., Ohtsubo, M., Kurogi, T., Nakashima, Y., Takihara, Y.
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659096
[Presentation] A new approach for activating mouse hematopoietic stem and progenitor cells by manipulating Geminin expression2012
- Author(s)
  Yasunaga S., Ohno Y., Ohtsubo M., Saeki K., Nakashima Y., Takihara Y.
- Organizer
  The 10th Annual Meeting of International Society for Stem Cell Research (ISSCR)
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23618008
[Presentation] Novel molecular regulatory network governing Geminin maintains hematopoietic homeostasis.2012
- Author(s)
  Takihara, Y.
- Organizer
  41st annual scientific meeting of the international society for hematology and stem cells
- Place of Presentation
  Amsterdam, Netherland
- Year and Date
  2012-08-23
- Data Source
  KAKENHI-PUBLICLY-23118519
[Presentation] Molecular role for Geminin in E2F-mediated transcriptional regulation2012
- Author(s)
  Saeki, K., Ohno, Y., Yasunaga, S., Ohtsubo, M., Kurogi, T., Nakashima, Y., Takihara, Y.
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659096
[Presentation] ポリコーム複合体1と Hoxb4による Geminin 制御と造血幹細胞活性2012
- Author(s)
  瀧原義宏
- Organizer
  特定領域研究「細胞増殖制御」終了シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659096
[Presentation] Hole for an Scmh1-mediated molecular network governing Geminin expression in hematopoiesis2012
- Author(s)
  Ohtsubo, M., Yasunaga, Y., Ohno, Y., Kawashima, A., Tetsuguchi, H., Saeki, K, Nakashima, Y., Takihara, Y.
- Organizer
  International Symposium 50^<th> Anniversary of RIRBM, Hiroshima University
- Place of Presentation
  広島国際会議場
- Year and Date
  2012-02-21
- Data Source
  KAKENHI-PROJECT-21602004
[Presentation] Current hematopoietic stem cell transplantation therapy and the perspective2012
- Author(s)
  Takihara, Y.
- Organizer
  The 1^<st> international symposium on phoenix leader education program for renaissance from radiation disaster
- Place of Presentation
  Hiroshima(招待講演)
- Year and Date
  2012-02-21
- Data Source
  KAKENHI-PROJECT-22390195
[Presentation] Novel molecular regulatory network governing Geminin maintains hematopoietic homeostasis.2012
- Author(s)
  Takihara, Y., Yasunaga, S., Ohno, Y., Saeki, K., Nakashima, Y., Ohtsubo, M.
- Organizer
  41st annual scientific meeting of the international society for hematology and stem cells
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-23659096
[Presentation] Functional analysis of Pcgf5 (Polycomb Ring Finger 5) gene during Cardiogenesis.2012
- Author(s)
  Shirai, M., Takihara, Y., Morisaki, T
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659096
[Presentation] Scmh1, a member of Polycomb-complex 1, maintains hematopoietic homeostasis through the regulation of Geminin protein stability2012
- Author(s)
  Takihara, Y., Ohno, Y.,Yasunaga, S., Saeki, K., Kurogi, T., Nakashima, Y., Ohtsubo, M.
- Organizer
  International symposium: Genetic and Epigenetic Control of Cell Fate
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23659096
[Presentation] Scmh1 regulates Geminin through the ubiquitin- proteasome systems to govern hematopoietic homeostasis2012
- Author(s)
  Yasunaga S., Ohno Y., Saeki K., Nakashima Y., Ohtsubo M., Takihara Y.
- Organizer
  The 74th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-23618008
[Presentation] ポリコーム複合体1と Hoxb4による Geminin 制御と造血幹細胞活性2012
- Author(s)
  瀧原義宏
- Organizer
  特定領域研究「細胞増殖制御」終了シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22390195
[Presentation] Role for an Scmh1-mediated molecular network governing Geminin expression in hematopoiesis2012
- Author(s)
  Ohtsubo, M., Yasunaga, Y., Ohno, Y., Kawashima, A., Tetsuguchi, H., Saeki, K., Nakashima, Y., Takihara, Y.
- Organizer
  International Symposium 50^<th> Anniversary of RIRBM, Hiroshima University
- Place of Presentation
  広島国際会議場
- Year and Date
  2012-02-21
- Data Source
  KAKENHI-PROJECT-21602004
[Presentation] Novel molecular regulatory network governing Geminin maintains hematopoietic homeostasis.2012
- Author(s)
  Takihara, Y., Yasunaga, S., Ohno, Y., Saeki, K., Nakashima, Y., Ohtsubo, M.
- Organizer
  41st annual scientific meeting of the international society for hematology and stem cells
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-22390195
[Presentation] 心臓発生における、ポリコーム遺伝子群の発現及び機能解析2012
- Author(s)
  白井学、瀧原義宏、森崎隆幸
- Organizer
  日本心臓血管発生研究会
- Place of Presentation
  熱海
- Data Source
  KAKENHI-PROJECT-23659096
[Presentation] Current hematopoietic stem cell transplantation therapy and the perspective2012
- Author(s)
  Takihara, Y.
- Organizer
  The 1^<st> international symposium on phoenix leader education program for renaissance from radiation disaster
- Place of Presentation
  Hiroshima(招待講演)
- Year and Date
  2012-02-21
- Data Source
  KAKENHI-PUBLICLY-23118519
[Presentation] A new strategy for maintaining HSC activity through the modulation of Geminin expression2011
- Author(s)
  Yasunaga, Y., Ohno, Y., Ohtsubo, M., Furutani, T., Kawashima, A., Tetsuguchi, H., Saeki, K., Nakashima, Y., Takihara, Y.
- Organizer
  日本血液学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-21602004
[Presentation] ポリコーム遺伝子群の心臓形態形成に対する発現・機能解析2011
- Author(s)
  白井学、瀧原義宏、森崎隆幸
- Organizer
  心臓血管発生研究会
- Place of Presentation
  郡山
- Data Source
  KAKENHI-PROJECT-23659096
[Presentation] Distribution of Polycomb-group proteins in the developing heart2011
- Author(s)
  Shirai, M., Takihara, Y., Morisaki, T
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659096
[Presentation] Scmhl deficiency up-regulates transcription of Hox genes to maintain the expression level of Geminin, that may play a crucial role for sustaining hematopoiesis.2011
- Author(s)
  Yasunaga S., Ohtsubo M., Ohno Y., Mori S., Furutani T., Kawashima A., Tetsuguchi H., Nakashima Y., Takihara Y.
- Organizer
  The First RIRBM International SymposiumBMB : Genome damage and non-cancerous diseases
- Place of Presentation
  Hiroshima, Japan.
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] Role of DNA replication licensing system in the regulation of haematopoietic stem cells2010
- Author(s)
  Takihara, Y.
- Organizer
  International Symposium, "Cell Cycle and Development"
- Place of Presentation
  Kyoto
- Year and Date
  2010-03-16
- Data Source
  KAKENHI-PROJECT-20058025
[Presentation] 造血幹細胞制御における DNA複製ライセンス化制御因子の役割2010
- Author(s)
  瀧原義宏
- Organizer
  第9回日本再生医療学会総会シンポジウム 13「造血幹細胞」
- Place of Presentation
  広島
- Year and Date
  2010-03-19
- Data Source
  KAKENHI-PROJECT-22390195
[Presentation] Scmhl, a member of Polycomb complex 1, regulates hematopoiesis either through Geminin Ubiquitination or through repression of Hox genes.2010
- Author(s)
  Yasunaga S., Ohtsubo M., Ohno Y., Mori S., Furutani T., Kawashima A., Tetsuguchi H., Nakashima Y., Takihara Y.
- Organizer
  BMB (Biochemistry and Molecular Biology) 2010
- Place of Presentation
  Kobe, Japan.
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] Role for Geminin in hematopoietic stem cell regulation.2010
- Author(s)
  Yasunaga S., Ohno Y., Ohtsubo M, Tsumura, M., Kageyama Y., Mori S., Nakashima Y., Takihara Y.
- Organizer
  The 8^<th> Stem Cell Research Symposium
- Place of Presentation
  Awaji, Japan.
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] Role for Geminin in sustaining hematopoietic stem cell activity.2010
- Author(s)
  Takihara, Y.
- Organizer
  The 13thUS-Japan Cellular and Gene Therapy Conference: Systems Biology in Cell Cycle Regulation, National Institute of Health
- Place of Presentation
  Bethesda, Maryland, USA
- Year and Date
  2010-02-25
- Data Source
  KAKENHI-PROJECT-22390195
[Presentation] B細胞性リンパ腫におけるBMI-1の高発現はSurvivinの発現を促進し、抗癌剤耐性に関与する2010
- Author(s)
  ジョイータ・バタチャリーヤ, 三原圭一朗, 大坪素秋, 安永晋一郎, 星正治, 瀧原義宏, 木村昭郎
- Organizer
  第71回日本血液学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-20591128
[Presentation] B-cell lymphoma cells overexpressing BMI-1 are correlated with drug resistance through enhanced expression of survivin and are effectively eliminated by T cells with anti-CD38 chimeric receptor.2010
- Author(s)
  ジョイータ・バタチャリーヤ, 三原圭一朗, 大坪素秋, 安永晋一郎, 瀧原義宏, 星正治, 木村昭郎
- Organizer
  52nd ASH Annual Meeting
- Place of Presentation
  Orlando, USA
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-20591128
[Presentation] A role for Geminin in sustaining activity of Haemopoietic stem and progenitor cells.2010
- Author(s)
  Yasunaga S., Ohno Y., Ohtsubo M., Tsumura M., Mori S., Nakashima Y., Kobayashi M., Takihara Y.
- Organizer
  The 72^<nd> Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Yokohama, Japan.
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] Overexpression of bmi-1 is correlated with drug resistance in b-cell lymphomas through enhanced expression of survivin.2010
- Author(s)
  ジョイータ・バタチャリーヤ, 三原圭一朗, 大坪素秋, 安永晋一郎, 瀧原義宏, 星正治, 木村昭郎
- Organizer
  ISEH2010
- Place of Presentation
  Melbourne Australia
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-20591128
[Presentation] Molecular role of Scmhl, a member of Polycomb complex 1. Which plays a crucial role for governing the hematopoietic stem cell activity.2009
- Author(s)
  Yasunaga S., Ohtsubo M., Ohno Y., Tsumura, M., Kageyama Y., Mori S., Nakashima Y., Takihara Y.
- Organizer
  The 32^<nd> Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Yokohama, Japan.
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] Molecular role of Scmhl, a member of Polycomb complex 1. Which plays a crucial role for governing the hematopoietic stem cell activity.2009
- Author(s)
  安永晋一郎, 大野芳典, 大坪素秋, 津村弥来, 影山由佳, 時元利恵, 瀧原義宏
- Organizer
  The 7^<th> Stem Cell Research Symposium
- Place of Presentation
  Tokyo, Japan.
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] HSCの活性維持に必須なポリコーム複合体1の構成因子Scmhlの機能ドメインの解析2009
- Author(s)
  大坪素秋、安永晋一郎、津村弥来、大野芳典、影山由佳、森彩華、時元利恵、小林正夫、瀧原義宏
- Organizer
  第71回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] Study of a 5-FU-induced stabilization signal for Scmh1, a component of Polycomb-group complex 1 E3 ligase2009
- Author(s)
  Ohtsubo, M., Yasunaga, S., Ohno, Y., Tsumura, M., Kageyama, Y., Mori, S., Takihara, Y.
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21602004
[Presentation] Role of Scmh1 in the regulation of Polycomb-group complex 1, which acts as the E3 ubiquitin ligase for histone H2A and Geminin2009
- Author(s)
  Ohtsubo, M., Yasunaga, S., Tsumura, M., Ohno, Y., Kageyama, Y., Kimura, S., Tokimoto, R., Takihara, Y.
- Organizer
  The 7th Stem Cell Research Symposium
- Place of Presentation
  Tokyo
- Year and Date
  2009-05-16
- Data Source
  KAKENHI-PROJECT-21602004
[Presentation] 造血幹細胞の活性制御におけるGemininの役割2008
- Author(s)
  瀧原義宏
- Organizer
  第31回日本分子生物学会年会・第81会日本生化学会大会合同大会(シンポジウム)
- Place of Presentation
  神戸市
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20659152
[Presentation] Gemininによる造血幹細胞制御の分子基盤2008
- Author(s)
  安永晋一郎、大坪素秋、大野芳典、影山由佳、津村弥来、岡田賢、時元利恵、小林正夫、瀧原義宏
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会・合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] 造血幹細胞の活性制御におけるGemininの役割2008
- Author(s)
  瀧原義宏
- Organizer
  第31回日本分子生物学会年会・第81会日本生化学会大会合同大会(シンポジウム)
- Place of Presentation
  神戸市
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20058025
[Presentation] 造血幹細胞制御におけるGemininの役割2008
- Author(s)
  安永晋一郎、大坪素秋、大野芳典、影山由佳、津村弥来、岡田賢、石川暢恒、白尾謙一郎、時元利恵、小林正夫、瀧原義宏
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20610003
[Presentation] Analysis of molecular rele for Geminin in self-renewal and differentiation of HSCs.
- Author(s)
  Suzuki-Takedachi K., Yasunaga S., Ohno Y., Kurogi T., Santo M., Ohtsubo M., Takihara Y.
- Organizer
  The 5th International Symposium of RIRBM, Hiroshima University
- Place of Presentation
  Hiroshima, Japan
- Year and Date
  2015-03-02 – 2015-03-03
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] Geminin visualization aids detailed molecular analysis of self-renewing hematopoietic stem cells.
- Author(s)
  Yasunaga S., Ohno Y., Suzuki-Takedachi K., Kurogi T., Santo M., Ohtsubo M., Takihara Y.
- Organizer
  The 76th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Osaka, Japan
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] Simple diagnosis of STAT1 gain-of-function alleles in patient with chronic mucocutaneous candidiasis presenting various clinical signs.
- Author(s)
  Mizoguchi Y., Okada S., Tsumura M., Yasunaga S., Takihara Y., Casanova J.-L., Morio T., Kobayashi M.
- Organizer
  The 5th International Symposium of RIRBM, Hiroshima University
- Place of Presentation
  Hiroshima, Japan
- Year and Date
  2015-03-02 – 2015-03-03
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] A new strategy for manipulating HSC activity through the modulation of Geminin expression.
- Author(s)
  Yasunaga S., Ohno Y., Ohtsubo M., Furutani T., Kawashima A., Tetsuguchi H., Saeki K., Nakashima Y., Takihara Y.
- Organizer
  第７３回日本血液学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23618008
[Presentation] Geminin regulates transcription via chromatin remodeling to govern cellular proliferation and differentiation
- Author(s)
  Ohno, Y., Yasunaga, S., Kurogi, T., Suzuki-Takedachi, K., Santo, M., Ohtsubo, M., Takihara, Y.
- Organizer
  The 12nd Stem Cell Research Symposium
- Place of Presentation
  福岡、九州大学医学部百年講堂
- Year and Date
  2014-05-30 – 2014-05-31
- Data Source
  KAKENHI-PUBLICLY-25118717
[Presentation] Geminin aids detailed molecular analysis of self-renewing hematopoietic stem cells
- Author(s)
  Yasunaga, S., Ohno, S., Suzuki-Takedachi, K., Kurogi, T., Santo, M., Ohtsubo, M. Takihara, Y.
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪、大阪国際会議場
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PUBLICLY-25118717
[Presentation] Molecular role for Geminin in governing hematopoietic stem cell activity
- Author(s)
  Takihara, Y.
- Organizer
  Views into nuclear function: A See Drug Workshop
- Place of Presentation
  Patras, Greece
- Year and Date
  2014-09-11 – 2014-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-25670096
[Presentation] Geminin-EYFP knock-in mice provide a powerful tool for dissecting a molecular mechanism regulating self-renewal or differentiation of hematopoietic stem cells.
- Author(s)
  Suzuki-Takedachi K., Yasunaga S., Ohno Y., Kurogi T., Ohtsubo M., Takihara Y.
- Organizer
  The 37th Annual Meeting of the Molecular Biology of Japan
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] Geminin regulates transcription via chromatin remodeling to govern cellular proliferation and differentiation.
- Author(s)
  Ohno Y., Yasunaga S., Kurogi T., Suzuki-Takedachi K., Santo M., Ohtsubo M., Takihara Y.
- Organizer
  The 12th Stem Cell Research Symposium
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2014-05-30 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] Direct transmission of a cell-penetrating form of Geminin, a regulator for hematopoietic stem cells
- Author(s)
  Ohno, S., Yasunaga, S., Kurogi, T., Suzuki-Takedachi, K., Santo, M., Ohtsubo, M. Takihara, Y.
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪、大阪国際会議場
- Year and Date
  2014-10-30 – 2014-11-02
- Data Source
  KAKENHI-PUBLICLY-25118717
[Presentation] Functional roles of Polycomb Ring Finger 5 (Pcgf5) in the heart of adult mice.
- Author(s)
  Shirai, M., Otani, K., Tsuchimochi, H., Takihara, Y., Morisaki, T.
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25670096
[Presentation] Molecular role for Geminin in governing hematopoietic stem cell activity
- Author(s)
  Takihara, Y.
- Organizer
  Views into nuclear function: A See Drug Workshop
- Place of Presentation
  Patras, Greece
- Year and Date
  2014-09-11 – 2014-09-13
- Invited
- Data Source
  KAKENHI-PUBLICLY-25118717
[Presentation] Geminin-EYFP knock-in mice provide a powerful tool for dissecting a molecular mechanism regulating self-renewal or differentiation of hematopoietic stem cells
- Author(s)
  Suzuki-Takedachi, K., Yasunaga, S., Ohno, Y., Kurogi, T., Santo, M., Ohtsubo, M., Takihara, Y.
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PUBLICLY-25118717
[Presentation] Direct transmission of a cell-penetrating form of Geminin, a regulator for hematopoietic stem cells.
- Author(s)
  Ohno Y., Yasunaga S., Kurogi T., Suzuki-Takedachi K., Santo M., Ohtsubo M., Takihara Y.
- Organizer
  The 76th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Osaka, Japan
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] Cell-penetrating recombinant Geminin protein may provide a new strategy for regulating self-renewal or cellular differentiation in hematopoietic stem cells.
- Author(s)
  Kurogi T., Ohno Y., Yasunaga S., Suzuki-Takedachi K., Santo M., Masuhiro Y., Hanazawa S., Ohtsubo M., Takihara Y.
- Organizer
  The 37th Annual Meeting of the Molecular Biology of Japan
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] Direct transduction of a cell-penetrating form of Geminin, a molecule regulating DNA replication and chromatin remodeling.
- Author(s)
  Takihara Y., Yasunaga S., Ohno Y., Kurogi T., Suzuki-Takedachi K., , Santo M., Ohtsubo M.
- Organizer
  ISEH (International Society for Experimental Hematology) 43rd Annual Scientific Meeting
- Place of Presentation
  Montreal , Canada
- Year and Date
  2014-08-21 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] Cell-penetrating recombinant Geminin protein may provide a new strategy for regulating self-renewal or cellular differentiation in hematopoietic stem cells
- Author(s)
  Kurogi, T.,　Ohno, Y., Yasunaga, S., Suzuki-Takedachi, K.,, Santo, M., Masuhiro, Y., Hanazawa, S., Ohtsubo, M., Takihara, Y.
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PUBLICLY-25118717
[Presentation] Cell-penetrating Geminin is exerted to provide a new strategy for manipulating the activity and number of HSCs.
- Author(s)
  Kurogi T., Ohno Y., Yasunaga S., Suzuki-Takedachi K., Santo M., Ohtsubo M., Takihara Y.
- Organizer
  The 5th International Symposium of RIRBM, Hiroshima University
- Place of Presentation
  Hiroshima, Japan
- Year and Date
  2015-03-02 – 2015-03-03
- Data Source
  KAKENHI-PROJECT-26501004
[Presentation] Direct transduction of a cell-penetrating form of Geminin, a molecule regulating DNA replication and chromatin remodeling
- Author(s)
  Takihara, Y., Yasunaga, S., Ohno, Y., Kurogi, T., Suzuki-Takedachi, K., Santo, M., Ohtsubo, M.
- Organizer
  The 43rd Annual Scientific Meeting of the ISEH-International Society of Experimental Hematology
- Place of Presentation
  Montreal, Canada
- Year and Date
  2014-08-21 – 2014-08-24
- Data Source
  KAKENHI-PUBLICLY-25118717
[Presentation] Identification and functional analysis of self-renewing hematopoietic stem cells by using Geminin-EYFP knock-in mice.
- Author(s)
  Yasunaga S., Ohno Y., Suzuki-Takedachi K., Kurogi T., , Santo M., Ohtsubo M., Takihara Y.
- Organizer
  The 12th Stem Cell Research Symposium
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2014-05-30 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-26501004

1. YASUNAGA Shin'ichiro (50336111)

# of Collaborated Projects: 17 results

# of Collaborated Products: 97 results
2. OHTSUBO Motoaki (10211799)

# of Collaborated Projects: 12 results

# of Collaborated Products: 31 results
3. SHINADA Kazunori (40037354)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
4. NISHIGUCHI Seiji (90237686)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
5. TOMOTSUNE Daihachiro (80283802)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
6. OHNO Yoshinori (10548986)

# of Collaborated Projects: 7 results

# of Collaborated Products: 67 results
7. SHIRAI Manabu (70294121)

# of Collaborated Projects: 6 results

# of Collaborated Products: 9 results
8. NOMURA Midori (60263315)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
9. NOMIYAMA Hisayuki (00156225)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. MAEDA Shuichiro (10117244)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. HIGASINAKAGAWA Toru (70131935)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. SETOYAMA Chiaki (60040250)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. JOH Tadashi (50243259)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. TAKIHARA Keiko (70252640)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
15. 原純一 (00238156)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 三好淳 (80166214)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. GOTTESMAN Max E.

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. BROCK Hugh W

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
19. MIHARA Keichiro (90363077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
20. TSUJI Kohichiro (50179991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. MIWA Takeshi (20174229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. NISHITANI Hideo (40253455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 三浦直行 (40165965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 里方一郎 (70170800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 横山高彦 (70191525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 栗原裕基 (20221947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 岡本三紀 (20332455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 太田秀明 (60322187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. TAKEDACHI Kyoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
30. Sato MIMOKO

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
31. KUROGI Toshiaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
32. YAMADA Hiromi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. HONDA Barry M

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 竹内隆

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. ROBERTSON El

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. ROBERTSON Elizabeth

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. COSTANTINI F

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. COSTANTINI Franklin d.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. CONSTANTINI エフ.ディー.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. ROBERTSON E.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. F D Constant

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. E J Robertso

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. MAX E Gottes

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. HODGSON Jaco

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. TSUMURA Miyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
46. MATSUOKA Yoshikazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. OKADA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
48. TAJIMA Go

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. HARA Keiichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 森尾友宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. 瀬川波子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 小林正夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takihara Yoshihiro 瀧原 義宏

TAKIHARA Yoshihiro 瀧原 義宏

滝原 義宏 タキハラ ヨシヒロ

Research Projects

Research Products

Co-Researchers

Molecular and cellular analyses of hematopoietic stem cell damage induced by low dose-rate irradiationPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Detection of cell-cycling cardiac muscle cells by visualizing Geminin, and regeneration of cardiac muscle cellsPrincipal Investigator

Principal Investigator

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Research Institution

Basic research on regulatory system for self-renewal and differentiation of hematopoietic stem cells for the purpose of future application to regenerative medicine

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

造血幹細胞の自己複製と分化の誘導を掛け分ける分子基盤Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular role for Geminin in maintaining cardiac musclesPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

造血幹細胞の自己複製と分化の誘導を掛け分ける分子基盤Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of regulatory mechanism for activity of hematopoietic stem cell mediated by regulation of Geminin protein

Principal Investigator

Project Period (FY)

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Research Institution

Detection and functional analysis of cardiac stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

Induction of hematopoietic stemcells from iPS cells and the molecular basis in the inductionPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Analysis of Hematopoietic stem cell regulation through Polycomb-group complex 1

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

造血幹細胞の活性を支持するGemininの分子制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug-resistant genes downstream of Polycomb group genes in leukemia stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of hematopoietic stem cell regulation through Geminin ubiquitination

Principal Investigator

Takihara Yoshihiro 瀧原義宏

TAKIHARA Yoshihiro 瀧原義宏

滝原義宏タキハラヨシヒロ