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SHINADA Kazunori  島田 和典

ORCIDConnect your ORCID iD *help
Researcher Number 40037354
External Links
Affiliation (based on the past Project Information) *help 1990 – 1999: 大阪大学, 微生物病研究所, 教授
1986 – 1989: 熊本大学, 医学部, 教授
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / General medical chemistry
Except Principal Investigator
Human genetics / Biological Sciences / 分子遺伝学・分子生理学 / Laboratory animal science
Keywords
Principal Investigator
遺伝子標的組み込み / rae28遺伝子 / トランスサイレチン / ポリホメオティック遺伝子 / CATCH22症候群 / bmil / rae28 / neural crest / ノックアウトマウス / LD78 … More / サイトカイン / 胚性幹細胞 / Gene targeting / Homologous recombination / ES細胞 / ジーンターゲティング / 神経堤細胞 / protein interactions / Polycomb group / Hox / segment specification / polyhomeotic / 疾患モデル / Hox遺伝子 / Nkx2.5 / Hand1 / ANF / rae28 gene / 発現調節 / Jurkat / K562 / プロモ-タ- / 偽遺伝子 / Actー2 / AT744 / 細胞増殖 / 炎症 / 走化性 / 発現誘導 / 相同DNA間組換え / 疾患モデルマウス / キメラマウス / プレアルブミン / アミロイド-シス / 遺伝性疾患 / Embryonic stem cell / Mouse model for human diseases / Chimeric mouse / Prealbumin / Amyloidosis / Hereditary diseases / アスパラギン酸ーリンゴ酸シャトル / アイソザイム / 細胞質型AspAT遺伝子 / ミトコンドリア型AspAT遺伝子 / 細胞質型MDH遺伝子 / ミトコンドリア型MDH遺伝子 / 遺伝子発現 / アスバラギン酸ーーリンゴ酸シャトル / GRE配列 / ミトコンドリア / マウス / 細胞質 / アスパラギン酸・リンゴ酸シャトル / トランスアミナ-ゼ / リンゴ酸脱水素酵素 / Malate-aspartate Shuttle / Isoenzyme / cAspAT / mAspAT / cMDH / mMDH / Gene Expression / 置換ベクター / ビタミンA / レチノール / レチノール結合タンパク質 / 甲状腺ホルモン / アミロイド / 血清アミロイドP成分 / ES / FAP / Transthyretin / TTR-deficient mouse / Retinol / RBP / Thyroid hormone / Replacement type vector / 相同組換え / F9細胞 / メチル化 / 遺伝病 / モデルマウス / 選択マーカー / 遺伝子標的組込み / Targeted integration / ES cell / F9 cell / Transthyretin. / Methylation / Inherited disease / 胚性腫瘍細胞 / 微小変異 / ral28遺伝子 / 臓器形成制御 / ショウジョウバエ / 臓器形成不全 / ファロ-の四徴 / polyomeotic / Pc-G遺伝子 / M33 / bmi1 / Polycomb / Pc-G遺伝子群 / polyhomeotic遺伝子 / Polycomb遺伝子 / M33遺伝子 / bmi-1遺伝子 / ポリコーム遺伝子群 / Scmh1遺伝子 / 造血幹細胞 / Hoxb3遺伝子 / 遺伝子発現維持 / レトロウイルス / Scmhl遺伝子 / Polycomb group of genes / Scmhl gene / hematopoietic stem cell / Hoxb3 gene / gene expression pattern / maintenance / retrovirus / 神経堤 / 先天性心疾患 / disease model mice / knockout mouse / Hox gene / Nkx2.5 gene / CATCH22 syndorme / congenital heart disease … More
Except Principal Investigator
トランスジェニックマウス / 部位特異的組換え / トランスポゾン / 血清アミロイドP成分 / 疾患モデルマウス / アミロイドーシス / 家族性アミロイドポリニューロパチー / RecA / ゲノム / 人工染色体 / 染色体地図 / ハンチントン舞踏病 / インタ-ロイキン / ミニサテライト / 動原体 / 抗原受容体遺伝子 / クラススイッチ組換え / DNA逆位 / DNAトポイソメラ-ゼ / 遺伝子の標的組込み / 家族性アミロイド-シス / TーDNA組込み / 免疫グロブリン遺伝子 / T細胞抗原レセプター遺伝子 / 非相同組換え / 標的遺伝子組換え / T-DNA / 遺伝子脆弱部位 / ポリコーム遺伝子群 / rae28遺伝子 / Scmhl遺伝子 / ノックアウトマウス / 造血前駆細胞 / 造血幹細胞 / 形質転換動物 / 実験医学 / 遺伝性疾患モデル動物作製 / 形質転換性病態モデル動物 / アミロイド-シス / プレアルブミン / アミロイド / 常染色体性優性遺伝病 / 急性期反応 / cDNA / 遺伝子DNA / ペントラキシン / 急性期蛋白 / C反応性蛋白質 / 発癌プロモーター / 遺伝子発現 / マウステラトカルシノーマ細胞 / F9 / cDNAクローニング / 遺伝的組換え / 遺伝子のターゲッティング / 大腸菌 / 哺乳動物 / 遺伝子の人工的改変 / 改変遺伝子の各種細胞への導入 / キメラ個体の作成 / エンハンサー / SV40 / 転写調節 / 相同組換え / 高等真核生物 / DNA修復 / モデル動物 / 実験動物 / Rad51 / マウス / 細胞周期 / 高頻度相同組え系 / 酸母 / RAD51 / RAD52 / Homologous recombination / Higher eukaryotes / DNA repair / Experimantal Model animals / トランスサイレチン / ジーンターゲッティング / 胚幹細胞 / トランスサイレチン(プレアルブミン) / ジーンターゲティング / amyloidosis / transthyretin / mouse model of human disease / familial amyloidotic polyneuropathy / gene targeting / embryonic Stem cells / serum amyloid P component / transgenic mouse / アスパラギン酸トランスアミナーゼ / 酵素の構造と機能相関 / 部位特異的突然変異 / リンゴ酸・アスパラギン酸シャトル / アイソザイム遺伝子 / アイソザイムの発現調節 / 酵素の機構と機能相関 / リンゴ酸アスパラギン酸シヤトル / アイソザイム遺伝子の比較 / 酵素前駆体のミトコンドリヤ移入シグナル / アイソザイムの発現調節機構 / 酵素の構造機能相関 / アスパラギン酸・リンゴ酸シャトル / 哺乳動物酵素の酵母による発現 / リンゴ酸脱水素酵素 / トランスアミナーゼ / 酵素の構造と機能 / 酵素の発現調節機構 / Aspartate aminotransferase / Malate dehydrogenase / Malate-aspartate shuttle / Enzyme structure-function / Site-directed mutagenesis / Isozyme genes Less
  • Research Projects

    (22 results)
  • Co-Researchers

    (54 People)
  •  マウスポリコーム遺伝子群による造血の維持と制御の分子機構の研究

    • Principal Investigator
      瀧原 義宏
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Regulation of organogenesis and hematopoiesis in developmentPrincipal Investigator

    • Principal Investigator
      SHIMADA Kazunori
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka University
  •  Study of CATCH22 syndorme using disease model micePrincipal Investigator

    • Principal Investigator
      SHIMADA Kazunori
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka University
  •  REGULATION OF MORPHOGENESIS IN EARLY MOUSE DEVELOPMENTPrincipal Investigator

    • Principal Investigator
      SHIMADA Kazunori
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka University
  •  Molecular Approach to an Amyloidosis by Using Gene Targeting

    • Principal Investigator
      MAEDA Shuichiro
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Yamanashi Medical University
  •  GENERATION OF MOUSE MODELS FOR HUMAN GENETIC DISEASESTHROUGH GENE TARGETINGPrincipal Investigator

    • Principal Investigator
      SHIMADA Kazunori
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka University
  •  生理機能の発現と組換え機構

    • Principal Investigator
      池田 日出男
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Use of embryonic stem cells to introduce mutations into micePrincipal Investigator

    • Principal Investigator
      SHIMADA Kazunori
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Research Institute for Microbial Diseases, Osaka University
  •  Construction of mouse model of human diseases by gene targetingPrincipal Investigator

    • Principal Investigator
      SHIMADA Kazunori
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka University
  •  細胞増殖を制御する新しいサイトカインLD78α、β、γの遺伝子構造と作用機構の研究Principal Investigator

    • Principal Investigator
      島田 和典
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  染色体編成と人工染色体

    • Principal Investigator
      柳田 充弘
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  生理機能の発現と組換え機構

    • Principal Investigator
      池田 日出男
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Establishiment of systems to produce experimental model animals using highly efficient homologous recombination

    • Principal Investigator
      MATSUSHIRO Aizo
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      Kinki University
      Osaka University
  •  細胞増殖に関与する新しいサイトカインLD78の分子生物学的研究Principal Investigator

    • Principal Investigator
      島田 和典
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  Use of embryonic stem cell system to construct mouse model for human diseasesPrincipal Investigator

    • Principal Investigator
      SHINADA Kazunori
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Osaka University
      Kumamoto University
  •  Regulatory expression of the mitochondrial and cytosolic isoenzyme genes participating in the malate-aspartate shuttlePrincipal Investigator

    • Principal Investigator
      SHIMADA Kazunori
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka University
      Kumamoto University
  •  発癌プロモーターの刺激応答に関する分子生物学的研究

    • Principal Investigator
      瀬戸山 千秋
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kumamoto University
  •  遺伝子の再編とその制御に関する基礎及び応用的研究

    • Principal Investigator
      池田 日出男
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      分子遺伝学・分子生理学
    • Research Institution
      The University of Tokyo
  •  Simian viras40ウィルスエンハンサーの活性調節機構

    • Principal Investigator
      野見山 尚之
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University
  •  アミロイド-シスの発症機構と血清アミロイドP成分の関与に関する分子遺伝学的研究

    • Principal Investigator
      MAEDA Shuichiro
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Human genetics
    • Research Institution
      Kumamoto University
  •  実験医学領域における形質転換動物の応用

    • Principal Investigator
      荻田 善一
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Human genetics
    • Research Institution
      Toyama Medical and Pharmaceutical University
  •  Molecular biology of aspartate aminotransferase isoenzymes and metabolically related enzymes in higher animals: Molecular basis of catalytic competence and regulatory mechanism of gene expression

    • Principal Investigator
      MORINO Yoshimasa
    • Project Period (FY)
      1985 – 1988
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Research Institution
      Kumamoto University
  • 1.  TAKIHARA Yoshihiro (60226967)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 2.  MAEDA Shuichiro (10117244)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  NISHIGUCHI Seiji (90237686)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 4.  TOMOTSUNE Daihachiro (80283802)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 5.  SETOYAMA Chiaki (60040250)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 6.  NOMIYAMA Hisayuki (00156225)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  池田 日出男 (10012775)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  大石 道夫 (00126004)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  HIGASINAKAGAWA Toru (70131935)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  NOMURA Midori (60263315)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  駒野 照弥 (00087131)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  川市 正史 (00195041)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  續 輝久 (40155429)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  GOTTESMAN Max E.
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  BROCK Hugh W
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  COSTANTINI F
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  MATSUSHIRO Aizo (00029753)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  MORITA Takashi (70150349)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  JOH Tadashi (50243259)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  SHIRAI Manabu (70294121)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  MORINO Yoshimasa (30028352)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  KAGAMIYAMA Hiroyuki (80028555)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  柳田 充弘 (80025428)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  城石 俊彦 (90171058)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  榊 佳之 (10112327)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  大木 操 (00158792)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  山岸 秀夫 (90025429)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  小林 泰夫 (10013319)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  荻田 善一 (40109111)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  松田 一郎 (10000986)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  相沢 慎一 (60073011)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  御子柴 克彦 (30051840)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  山村 研一 (90115197)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  大坪 英一 (10158800)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  柴田 武彦 (70087550)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  小川 英行 (70028207)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  EPISKOPOU Vasso
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  SARAIVA Maria.J.M
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  HONDA Barry M
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  池田 穰衛
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  ROBERTSON El
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  ROBERTSON Elizabeth
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  COSTANTINI Franklin d.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  CONSTANTINI エフ.ディー.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  ROBERTSON E.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  F D Constant
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  E J Robertso
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 48.  MAX E Gottes
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 49.  BUXBAUM J.N.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 50.  GOTTESMAN M.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 51.  GOTTESMAN Max E
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 52.  COSTANTINI Franklin D
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 53.  BUXBAUM Joel N
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 54.  HODGSON Jaco
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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