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KAWAICHI Masashi
川市 正史
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Alternative Names
川市 正史 カワイチ マサシ
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Researcher Number
00195041
Affiliation (Current)
2022: 奈良先端科学技術大学院大学, 教育推進機構, 部門長
Affiliation (based on the past Project Information)
*help
2004 – 2007: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授
2000 – 2001: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授
1996: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授
1993 – 1994: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授
1993: 奈良先端科学技術大学院大学, 教授
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1988 – 1992: 京都大学, 医学部, 助教授
1988: 京都大学, 医学部医化学第1講座, 助教授
1987: 京都大学, 医学部, 講師
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Review Section/Research Field
Principal Investigator
General medical chemistry
/
Pathological medical chemistry
/
General medical chemistry
Except Principal Investigator
Pathological medical chemistry
Keywords
Principal Investigator
ショウジョウバエ / 末梢神経系発生 / Suppressor of Hairless / 認識DNA配列 / コラーゲン / 遺伝子破壊マウス / HtrA1 / VDJ-組換え / RBP-Jκ遺伝子 / DNA結合蛋白質
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/ RBP-Jk蛋白質 / VDJ-組換えシグナル / NF-kB認識配列 / E(spl)遺伝子 / 転写因子 / ゲルシフトアッセイ / コア認識配列 / ランダムオリゴマー / RBP-J_K遺伝子 / Enhancer of Split / Neurogenic Genes / 転写調節 / DNA結合ドメイン / Hairless gene / Drosophila / Lateral inhibition / promotor / Su(H)recognition motif / transcriputional regulation / RAG-1 / RAG-2 / V(D)J組換え / 2重鎖DNA切断反応 / 酵母内反応 / シャトルベクター / セリンプロテアーゼ / TGF-βファミリー / 変形性骨関節炎 / 細胞外期質 / フォリスタチン様蛋白質 / 関節炎モデル動物 / 軟骨細胞 / フォリスタチン様ドメイン / セリン蛋白質分解酵素 / 蛋白質分解酵素阻害剤 / LDL受容体ファミリー / PICK-1 / JIP-1 / JNK / 晩発性アルツハイマー病 / 細胞内取り込み / グルタミン酸受容体 / MAPキナーゼカスケード / LRP1B / JNKスカフォールド / PICK1 / NPXYモチーフ / アミロイドβ / プロB細胞 / プロT細胞 / DNAメチル化 / 免疫グロブリン遺伝子 / T細胞抗原受容体遺伝子 / リンパ球分化 / HtrAl / 変形性関節炎 / コラーゲン分泌 / C-プロペプチド / 骨密度 / オステオカルシン / 石灰化 / 肥大軟骨細胞 / HtrAセリンプロテアーゼ / 関節炎 / 加齢黄斑変性症 / bFGF / 軟骨分化 / 骨芽細胞分化 / 細胞外基質 / プロテオグリカン / TGF-β / 肥大軟骨 / 骨芽細胞 / Osteoarthritis / Collagens / C-pronentide / Bone density / Osteocalcine / Calcification / Hypertrophic chondrocvte
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Except Principal Investigator
部位特異的組換え / 免疫グロブリン遺伝子 / ショウジョウバエ / TGF-β / 遺伝性腫瘍 / MEN2A / 甲状腺髄様癌 / 副腎褐色細胞腫 / Loss of heterozygosity / rasオンコジン / 抗原受容体遺伝子 / クラススイッチ組換え / DNA逆位 / DNAトポイソメラ-ゼ / 遺伝子の標的組込み / 家族性アミロイド-シス / TーDNA組込み / T細胞抗原レセプター遺伝子 / 非相同組換え / 標的遺伝子組換え / トランスポゾン / T-DNA / 遺伝子脆弱部位 / Bリンパ球 / VDJ組換 / 骨髄多分化能細胞 / ストロ-マ細胞 / リコンビナ-ゼ / SーS組換え / 環状DNA / 抗体遺伝子再構成 / DNA結合タンパク質 / cDNAクローニング / integrase family / transgenic mouse / double isotype expression / trans splicing / ヒト抗体V_H鎖遺伝子 / 骨髄細胞からのリンパ球への分化 / クラススイッチ / IgM^+IgG^+B細胞 / IL-2 / IL-2R / トランスジュニックマウス / NK細胞 / 抗体遺伝子D断片 / Bリンパ球の分化 / IL-4 / IL-2リセプター / トランスジェーニックマウス / 染色体マップ / IL-4遺伝子 / IL-5遺伝子 / リンフォカイン遺伝子 / 人工突然変異 / インターロイキン2の受容体 / インターロイキン5 / エンハンサー / 多内分泌腫瘍症2A型(MEN2A) / 連鎖分析 / RFLPs / loss of beterozygosity / 胃癌 / 髄膜腫 / 遺伝子破壊 / 相同遺伝子組替え / 発生 / 胎生期致死 / 転写制御因子 / 胚性幹細胞 / 末梢神経 / 遺伝子組換え / Gene targeting / Homologous recombination / Embryonic lethal / Development / Transcriptional regulator / 関節炎 / HtrAl / セリンプロテアーゼ / 肥大化軟骨 / ノックアウトマウス / HtrA1セリンプロテアーゼ / コラーゲン / GFG / collagen / 骨分化 / arthritis / HtrA1 / serine protease / hypertrophic chondrocyte / knockout mouse
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Research Projects
(
16
results)
Research Products
(
8
results)
Co-Researchers
(
23
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Study on HtrA Serine Protea we Family Proteins Which Inhibit Signaling of TGF-βs
Principal Investigator
Principal Investigator
KAWAICHI Masashi
Project Period (FY)
2005 – 2007
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
General medical chemistry
Research Institution
Nara Institute of Science and Technology
How HtrA1 serine protease inhibit TGF-β signal and is involved in arthritis ?
Principal Investigator
OKA Chio
Project Period (FY)
2005 – 2006
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Pathological medical chemistry
Research Institution
Nara Institute of Science and Technology (NAIST)
新しいアルツハイマー病関連遺伝子LRP1Bの研究
Principal Investigator
Principal Investigator
川市 正史
Project Period (FY)
2004 – 2005
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Pathological medical chemistry
Research Institution
Nara Institute of Science and Technology
セリンプロテアーゼ、S8の阻害による関節炎発症抑制の検討
Principal Investigator
Principal Investigator
川市 正史
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Exploratory Research
Research Field
General medical chemistry
Research Institution
Nara Institute of Science and Technology
酵母を利用したV(D)J組換え機構の解析
Principal Investigator
Principal Investigator
川市 正史
Project Period (FY)
1996
Research Category
Grant-in-Aid for Exploratory Research
Research Field
General medical chemistry
Research Institution
Nara Institute of Science and Technology
Hairless遺伝子の解析
Principal Investigator
Principal Investigator
川市 正史
Project Period (FY)
1994
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Nara Institute of Science and Technology
生理機能の発現と組換え機構
Principal Investigator
池田 日出男
Project Period (FY)
1993
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
ショウジョウバエにおけるRBP-Jk遺伝子の機能の解析
Principal Investigator
Principal Investigator
川市 正史
Project Period (FY)
1993
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Nara Institute of Science and Technology
ショウジョウバエにおけるRBP-JK遺伝子の機能の解析
Principal Investigator
Principal Investigator
川市 正史
Project Period (FY)
1992
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Kyoto University
抗原受容体遺伝子の組換え認識配列に結合するRBP-Jk蛋白質の特異性の研究
Principal Investigator
Principal Investigator
川市 正史
Project Period (FY)
1992 – 1993
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
General medical chemistry
Research Institution
Nara Institute of Science and Technology
Kyoto University
Study on recombination signal binding protein ; RBP-Jkappa
Principal Investigator
NAKANO Toru
Project Period (FY)
1992 – 1993
Research Category
Grant-in-Aid for international Scientific Research
Research Institution
Kyoto University, Faculty of Medicine
生理機能の発現と組換え機構
Principal Investigator
池田 日出男
Project Period (FY)
1991
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
リンパ球細胞のTーおよびBー細胞への分化決定機構の解明
Principal Investigator
Principal Investigator
川市 正史
Project Period (FY)
1988
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
General medical chemistry
Research Institution
Kyoto University
DNA塩基配列の多型性を利用した遺伝子腫瘍の研究
Principal Investigator
高井 新一郎
Project Period (FY)
1988
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Osaka University
DNA塩基配列の多型性を利用した遺伝性腫瘍の研究
Principal Investigator
高井 新一郎
Project Period (FY)
1987 – 1989
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Osaka University
免疫系における多様性発現機構の分子遺伝学的研究
Principal Investigator
本庶 佑
Project Period (FY)
1986 – 1990
Research Category
Grant-in-Aid for Specially Promoted Research
Research Institution
Kyoto University
All
2006
2005
All
Journal Article
Presentation
[Journal Article] Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis
2005
Author(s)
Tsuchiya, A., Yano, M., Tocharus, J., Kojima, H., Fukumoto, M., Kawaichi, M., Oka, C
Journal Title
Bone 37
Pages
: 323-336
Description
「研究成果報告書概要(欧文)」より
Data Source
KAKENHI-PROJECT-17390079
[Journal Article] Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis.
2005
Author(s)
Tsuchiya, A., Yano, M., Tocharus, J., Kojima, H., Fukumoto, M., Kawaichi, M., Oka, C.
Journal Title
Bone 37
Pages
: 323-336
Description
「研究成果報告書概要(欧文)」より
Data Source
KAKENHI-PROJECT-17590268
[Journal Article] Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis.
2005
Author(s)
Tsuchiya, A., Yano, M., Tocharus, J., Kojima, H., Fukumoto, M., Kawaichi, M., Oka, C
Journal Title
Bone 37
Pages
: 323-336
Description
「研究成果報告書概要(和文)」より
Data Source
KAKENHI-PROJECT-17590268
[Journal Article] Expression of mouse HtrAl serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis
2005
Author(s)
Tsuchiya, A., Yano, M., Tocharus, J., Kojima, H., Fukumoto, M., Kawaichi, M. and Oka, C.
Journal Title
Bone 37
Pages
: 323-336
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
Data Source
KAKENHI-PROJECT-17390079
[Presentation] Roles of mouse HtrA1 serine protease in bone development and pathogenesis of osteoarthritis
2006
Author(s)
Hisae, Kojima, Akiho, Tsuchiya, Masashi, Kawaichi, Chio, Oka
Organizer
20th IUBMB International Congress
Place of Presentation
Kyoto
Description
「研究成果報告書概要(欧文)」より
Data Source
KAKENHI-PROJECT-17390079
[Presentation] Mammalian HtrAl is a highly regulated serine protease
2006
Author(s)
Chio Oka, Murwantoko, Masato Yano, Yoshifumi Ueta, Hisae Kojima, Akiho Tsuchiya, Masashi Kawaichi
Organizer
20th IUBMB International Congress.
Place of Presentation
Kyoto
Description
「研究成果報告書概要(和文)」より
Data Source
KAKENHI-PROJECT-17390079
[Presentation] Roles of mouse HtrAl serine protease in bone development and pathogenesis of osteoarthritis
2006
Author(s)
Hisae Kojima, Akiho Tsuchiya, Masashi Kawaichi, Chio Oka
Organizer
20th IUBMB International Congress.
Place of Presentation
Kyoto
Description
「研究成果報告書概要(和文)」より
Data Source
KAKENHI-PROJECT-17390079
[Presentation] Mammalian HtrA1 is a highly regulated serine protease
2006
Author(s)
Chio, Oka, Murwantoko, Masato, Yano, Yoshifumi, Ueta, Hisae, Kojima, Akiho, Tsuchiya, Masashi, Kawaichi
Organizer
20th IUBMB International Congress
Place of Presentation
Kyoto
Description
「研究成果報告書概要(欧文)」より
Data Source
KAKENHI-PROJECT-17390079
# of Projects (Dsc)
# of Projects (Asc)
1.
OKA Chio
(30263445)
# of Collaborated Projects:
4 results
# of Collaborated Products:
8 results
2.
TSUBATA Takeshi
(80197756)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
3.
高井 新一郎
(80028513)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
4.
三木 哲郎
(00174003)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
5.
池田 日出男
(10012775)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
6.
島田 和典
(40037354)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
7.
駒野 照弥
(00087131)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
8.
大石 道夫
(00126004)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
9.
本庶 佑
(80090504)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
10.
清水 章
(00162694)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
NAKANO Toru
(00172370)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
12.
小林 哲郎
(40162002)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
13.
山岸 秀夫
(90025429)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
14.
小林 泰夫
(10013319)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
15.
佐辺 寿孝
(40187282)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
16.
松浪 伯禎
(40192752)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
17.
木梨 達雄
(30202039)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
川上 敏明
(60143418)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
野間 隆文
(40189428)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
武田 俊一
(60188191)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
21.
元村 和由
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
22.
ASHBURNER Michael
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
23.
MAK Tak W.
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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