Shimohama Shun 下濱俊

… Alternative Names

SHIMOHAMA Syun 下濱俊

SHIMOHAMA Shun 下濱俊

下浜俊シモハマシユン

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Researcher Number	60235687
Other IDs
Affiliation (Current)	2025: 札幌医科大学, 医学部, 名誉教授
Affiliation (based on the past Project Information) *help	2021 – 2022: 札幌医科大学, 医学部, 名誉教授 2015 – 2020: 札幌医科大学, 医学部, 教授 2009 – 2013: 札幌医科大学, 医学部, 教授 2006: Sapporo medical university, Faculty of medicine, Professor, 医学部, 教授 2001 – 2005: 京都大学, 医学研究科, 助教授 … More 2002: Department of Environmental Biochemistry, Kyoto Pharmaceutical University, Professor, 医学部, 助教授 2000: Kyoto University, Graduate School of Medicine, Assistant Professor, 医学研究科, 講師 1999: 京都大学, 医学研究所, 助手 1999: 京都大学, 大学院・医学研究科, 助手 1995 – 1998: 京都大学, 医学研究科, 助手 1992 – 1998: 京都大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Neurology / Biological Sciences / Neurology / General internal medicine(including psychosomatic medicine) Except Principal Investigator Neurology / Neurology / Basic Section 52020:Neurology-related / Basic Section 52010:General internal medicine-related / Nerve anatomy/Neuropathology / Radiation science … More / Psychiatric science / Biological pharmacy / Cerebral neurosurgery / Medical sociology Less
Keywords	Principal Investigator アルツハイマー病 / グルタミン酸 / 細胞死 / ニコチン性受容体 / 治療 / 筋萎縮性側索硬化症 / 運動ニューロン / パーキンソン病 / アイソザイム / 酸化ストレス … More / Alzheimer's disease / 骨髄間葉系幹細胞 / プレセニリン / 神経変性疾患 / 神経保護 / 蛋白質 / 脳神経疾患 / グリア / アポトーシス / 神経細胞死 / シナプス / 神経原線維変化 / ミクログリア / cyclic GMP / IP_3 / GFAP / 骨髄幹細胞 / 血液脳関門 / 移植 / プロテアソーム / ドーパミンニューロン / プロテオミクス / 二次元電気泳動 / プロテオーム / α7受容体 / ニコチン / カスペース / CGMP / ALS / PI3キナーゼ / Aβ / βアミロイド / 脳虚血 / 保護作用 / ベータアミロイド / α4β2サブユニット / α7サブユニット / 機能探索分子 / アセチルコリン / 神経保護活性物質 / CA3 / パッチクランプ / 海馬 / 長期増強現象 / 脱リン酸 / 低分子量 / 酸性ホスファターゼ / チロシン / プロテインホスファターゼ / リン酸化 / 血小板 / デルタ / ホスホリパーゼC / 脳 / ホスホリパーゼC(PLC) / 電子常磁性共鳴法 / ニコチン受容体 / EPR / アミロイドβ / モデルマウス / 治療・予防薬 / ガランタミン / α7ニコチン性受容体作動薬 / cytokine / high mobility group protein-1 (HMG1) / heat-shock protein (HSP) / BiP (GRP78) / clearance / amyloid-β / microglia / GRP78 / BiP / PI3Kinase / preseniliu-1 / high-mobility group protein-1 / heat-shock protein / c. elegaus / サイトカイン / クリアランス / high mobility group protein-1(HMG1) / heat shock protein(HSP) / Bip(GRP78) / β-アミロイド / oxidative stress / protection / estradiol / cell death / motor neuron / Amyotrophic lateral sclerosis (ALS) / 増殖 / 変異SOD-1 / 野生株 / Zn superoxide dismutase(SOD-I) / Cu / 家族性筋萎縮性側索硬化症 / アミノフィリン / ホスホジエステラーゼ(PPE) / 保護効果 / エストラジオール / protein kinase C (PKC) / mutation / PLC-delta1 / isozyme / phospholipase C (PLC) / Inositol phospholipid / PHドメイン / 遺伝子変異 / PLC-γ1 / ゲルクロマトグラフィー / ホスホルハ-ゼC(PLC) / イノシトールリン脂質代謝 / IP3 / PIP2 / 機能障害 / pleckstrinhomology (PH) domain / ホスホリパーゼC(PLc) / プロテインキシナーゼC(PKC) / 突然変異 / PLC-δ1 / イノシトールリン脂質 / beta-actin / protein / neurodgenerative disease / human brain / data base / Two-dimensional electrophoresis / 大脳皮質 / 界面活性剤 / βアクチン / タンパク質 / アルツハイマー脳 / ヒト脳 / データベース / 二次元電気泳動法 / 多発性硬化症 / 神経疾患 / リアルタイムイメージング / セルマイグレーション / 脳実質浸潤 / 再生 / 骨髄間葉系細胞 / 変異SOD1 / SOD1 / 誘導剤 / HSP / 分子シャペロン / 遺伝子転写 / ベータカテニン / α-セクレターゼ / N-カドヘリン / アセチルコリンエステラーゼインヒビター / SOD1トランスジェニックマウス / APP / γ-セクレターゼ / SH-TY5Y細胞 / カドヘリン / MAPK / 封入体 / BDNF / αsynuclein / 質量分析 / 阻害剤 / ホスホジエステラーゼ / 脊髄運動ニューロン / MPP^+ / アルファシヌクレイン / 痴呆 / Fyn / PI3K / Aβ(βアミロイド) / 神経終末 / Bcl-2 / 老化 / 神経回路網 / 発生 / AP-1 site / エストロゲンレセプター / エストロゲン / ドーパミンニェーロン / レセプター / ヌクレオテド / イノシン / アデノシン / NOS(NO合成酵素) / NO / ドパミン受容体 / βシート構造 / D2受容体 / 作動薬 / ドーパミン / 神経伝達物質 / α4β2 サブユニット / 苔状線維 / カルバコール / 脳由来神経栄養因子 / 脳抽出物 / ドパミンニューロン / 初代培養中脳神経細胞 / 神経変性 / アシロイドベータ蛋白 / ニューロン / 酵素活性 / PKC-ε / カルシウム非依存性プロテインキナーゼC / カルシウム依存性プロテインキナーゼC / プロテインキナーゼC / パッチ電流 / KA / AMPA / EGF レセプター / 脳内蓄積物質 / プロテインキナーゼ / 脳内異常蓄積物質 / Pragressive suprannclear palsy / PLC活性 / tau(タウ) … More Except Principal Investigator パーキンソン病 / ALS / 細胞死 / グルタミン酸 / 神経細胞死 / 酸化ストレス / MPP^+ / Parkinson's disease / MPTP / 黒質 / 免疫細胞 / イメージング / レドックス / アルツハイマー病 / SOD1 / HSP / dopamine / Lewy body / proteasome / ニューロン死 / ドーパミン / プロテアソーム / α-シヌクレイン / アルツハイマー / 神経変性疾患 / Cerebral ischemia / Neurodegenerative disease / Neurotoxicity / Nerve growth factor / Recombinant brain-derived neurotrophic factor / Fasciculation / K channel / SIRTファミリー / fasciculation / NO / ドパミン / チロシン水酸化酵素 / アイソザイム / 海馬 / モデル動物 / ニコチン性アセチルコリン受容体 / 神経炎症 / 老化 / 酸素代謝 / モデルマウス / 電子常磁性共鳴 / 脳内レドクス / EPRイメージング / GFP / 6-OHDA / 脳神経疾患 / 骨髄キメララット / ミクログリア / 前駆細胞 / 分化 / 多発性硬化症 / 初代培養 / マイクロRNA / 変性 / オリゴデンドロサイト / 可視化 / 脳・神経 / ストレス / 磁気共鳴 / ROS / 脳・神経疾患 / EPR / MRI / 分子イメージング / 脳疾患 / CRISPR/Cas9 / トランスジェニックマウス / プレセニリン１ / BPSD / Neuroprotection / 神経保護 / catecholamine / neurodegenerative disease / neuronal death / heat shock protein / Parkinson disease / タンパク凝集 / 封入体 / グルタチオン / カテコラミン / 熱ショックタンパク / レビー小体 / rotenone / α-synuclein / MPP+ / ドーパミンニューロン / ミトコンドリア / Lewy小体 / ロテノン / Caspase family / Rat cerebral cortex / Rat heart / Acrylonitrile / Hyperoxia / Oxidative stress / Lipid peroxidation / Phospholipase C-δ1 / Phospholipase C isozyme / 脳 / ラット / イノシトールリン脂質代謝 / ホストリパーゼC / カスパーゼ / ラット心臓 / ラット脳 / レドックスシグナル / アクリロニトリル / ホスホリパーゼC / 脳虚血 / Brain derived neurotrophic factor / Discharge prohability / Dystonia / Central motor program / Familial / Multifocal motor neuropathy / ニューロパチー / アクリルアミド / ビタミンB_<12> / 血液神経関門 / 一側性上肢筋萎縮症 / MMN / central motor prosran / multitocal motor neuropathy / discharge prohability / dystonia / central motor program / familial / fascicalation / multifocal motor neuropathy / 福祉 / 高等専門教育 / 認知症医療 / 脳卒中医療 / 介護 / 卒後教育 / 福祉従事者 / 生涯教育 / 地域格差 / 認知症 / 脳卒中 / 福士従事者 / 介護従事者 / ヒストン脱アセチル化酵素 / 神経分子病態学 / MPP / 一酸化炭素 / 初代培養神経細胞 / ドパミン神経細胞 / K^+ channel / threshad electrotonus / magnetic stimulation / methylc : balamin / motor neuron disease / Multifocal Motor Neuropathy / K^+チャネル / PSTH / 大脳磁気刺激法 / TE法 / 細胞内情報伝達 / 視覚野 / 大脳視覚野 / 虚血 / 長期抑圧 / 長期増強 / シナプス伝達 / 神経変性 / ムスカリン受容体 / アセチルコリン / ニコチン受容体 / BDNF / 神経成長因子(NGF) / NMDA受容体 / トランスロケーション / プロテインキナーゼC / 内嗅皮質 / 情報伝達機構 / 神経難病 Less

Development of early diagnostic method using Alzheimer's disease model mice
- Principal Investigator
  
  FUJII Hirotada
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Health Sciences University of Hokkaido
Starting point of immune-cell crosstalk in Brain-blood system and therapeutic time window in Parkinson's disease.
- Principal Investigator
  
  Syuuichirou Suzuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Sapporo Medical University
Analysis of microRNA in oligodendrocyte degeneration
- Principal Investigator
  
  Hisahara Shin
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Sapporo Medical University
Origin of crosstalk between brain and blood immune cells in Parkinson's disease and its involvement in pathology
- Principal Investigator
  
  Suzuki Syuuichirou
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Sapporo Medical University
Regulation of oxidative stress in Alzheimer model mice and its application for treatmentPrincipal Investigator
- Principal Investigator
  
  Shimohama Shun
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Sapporo Medical University
Establishment of AD model mice harboring novel pathogenic PS1 mutation presenting "Behavioral and Psychological Symptoms of Dementia"
- Principal Investigator
  
  Kawamata Jun
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Sapporo Medical University
Molecular imaging of brain disease model mice by MRI and EPR imaging
- Principal Investigator
  
  FUJII HIROTADA
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Sapporo Medical University
The method of "pre and post " graduate medical education that correct regional disparity
- Principal Investigator
  
  MASAKI Saitoh
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical sociology
- Research Institution
  Sapporo Medical University
Pathophysiological analysis for the ischemic brain damage using in vitro blood-brain barrier systemPrincipal Investigator
- Principal Investigator
  
  SHIMOHAMA Shun
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Sapporo Medical University
Basic reserach for developing a new therapy by transplantation of mesenchymal stem cells against neurodegenerative diseasesPrincipal Investigator
- Principal Investigator
  
  SHIMOHAMA Shun
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Sapporo Medical University
Functional analysis of histone deacetylase SIRT in the pathophysiology of neurodegenerative disorders
- Principal Investigator
  
  HISAHARA Shin
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Sapporo Medical University
筋萎縮性側索硬化症治療薬としての分子シャペロン誘導剤の探索研究Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Sapporo Medical University
  Kyoto University
Mechanism of neuroprotection by the heat shock proteins in amyotrophic lateral sclerosis model mice (SOD1-G93S transgenic mice)
- Principal Investigator
  
  KAWAMATA Jun
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
アルツハイハー病におけるシナプス変性・脱落メカニズムの分子基盤の解明Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Molecular Mechanisms of Dopaminergic Neuronal Protection by Regulation of Proteasome Activity
- Principal Investigator
  
  SAWADA Hideyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Utano National Hospital, Clinical Research Center
  Kyoto University
アルツハイマー病におけるシナプス変性・脱落メカニズムの分子基盤の解明Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
ニコチン性受容体作動薬は筋萎縮性側索硬化症に対する新たな治療薬となりうるか?Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
プロテオームによるアルツハイマー病の病態解析法の開発Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
パーキンソン病のドーパミンニユーロン死と封入体形成におけるプロテアソームの役割Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Proteasome regulates dopaminergic neuronel degeneration and Lewy body formation
- Principal Investigator
  
  SAWADA Hideyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  KYOTO UNIVERSITY
プロテオームによるアルツハイマー病の病態解析法の開発Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
パーキンソン病におけるα-synuclein蓄積の病態的意義の解明Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
ホスホジエステラーゼ阻害薬は筋萎縮性側索硬化症の新たな治療薬となりうるか?Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
Neureu-glia interaction in Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  SHIMOHAMA Shou
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  KYOTO UNIVERSITY
Significance of Alteration of Phospholipase C-δ1 in the Brain Tissues through Oxidative Stress
- Principal Investigator
  
  FUJIMOTO Sadaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
ステロイド受容体ファミリーを介するドーパミンニューロン死の防御機構Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
神経回路網の形成・成熟・老化・病的過程におけるアポトーシス制御分子の役割Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
アルツハイマ・病におけるニューロン変性機序の解明Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
アデノシンによる脳虚血下の細胞生存とアポトーシス制御機構の解明Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
Molecular pathomechanism of amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  SHIMOHAMA Shon
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Neurology
- Research Institution
  KYOTO UNIVERSITY
機能探索分子の活用によるニコチン性受容体を介して発現される神経保護作用機構の解明Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
選択的神経細胞死およびニコチン受容体刺激による細胞死防御作用の分子機構の解明Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
海馬苔状繊維-CA3野シナプス可塑性におけるアヒチルコリン作動性神経系の役割Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
機能探索分子の活用によるニコチン性受容体を介して発現される神経保護作用機構の解明Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
ニコチン性受容体刺激による神経細胞死防御作用およびその分子機構の解明Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
神経伝達物質は神経保護活性物質としても機能するか?Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
パーキンソン病における黒質神経細胞死の機序と保護因子の探索
- Principal Investigator
  
  赤池昭紀
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
ヒト脳由来の新規神経保護活性物質の探索Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
Aberrant phosphoinositide metabolism in Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  SHIMOHAMA Shun
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  KYOTO UNIVERSITY
パーキンソン病における黒質神経細胞死の機序と保護因子の探索
- Principal Investigator
  
  赤池昭紀
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
海馬苔状線維-CA3野シナプスにおける長期増強の分子機能の解明Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
神経活動によるシナプスの抑圧・退行のメカニズム
- Principal Investigator
  
  川合述史
- Project Period (FY)
  1995 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Jichi Medical University
筋萎縮性側索硬化症と治療に関する研究
- Principal Investigator
  
  木村淳
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
アルツハイマー病におけるCa^<2+>非依存性novelプロテインキナーゼC異常Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
Analysis of human brain proteins by higy-resolution two dimensional gel electropheresisPrincipal Investigator
- Principal Investigator
  
  SHINOHARA Shun
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  KYOTO UNIVERSITY
アルツハイマー病脳内蓄積物質とイノシトールリン脂質代謝異常Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
パーキンソン病におる黒質神経細胞死の機序と保護因子の探索
- Principal Investigator
  
  AKAIKE Akinori
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
アルツハイマー病脳における異常なチロシンリン酸化とチロシンホスファターゼ異常Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
神経難病における神経細胞死と情報伝達機構異常
- Principal Investigator
  
  秋口一郎
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
アルツハイマー病脳内蓄積物質とイノシトールリン脂質代謝異常Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
アルツハイマー病における異常なタンパクリン酸化とプロテインホスファターゼ異常Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
神経難病における神経細胞死と情報伝達機構異常
- Principal Investigator
  
  AKIGUCHI Ichiro
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
アルツハイマー病脳内蓄積物質とイノシトールリン脂質代謝異常Principal Investigator
- Principal Investigator
  
  下濱俊
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
A Study on Pathophysiology of Amyotrophic Lateral Sclerosis (ALS)
- Principal Investigator
  
  KIMURA Jun
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  KYOTO UNIVERSITY
Treatment of Neurodegenerative disease with recombinent cells
- Principal Investigator
  
  TSUKAHARA Tetsuya
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  National Cardio Vascular Center Research Institute

[Book] Nicotinic Acetylcholine Receptor Signaling in Neuroprotection2018
- Author(s)
  Akaike A, Shimohama S, Misu Y
- Total Pages
  191
- Publisher
  Springer
- ISBN
  9789811084874
- Data Source
  KAKENHI-PROJECT-16H05279
[Book] 認知症ハンドブック2013
- Author(s)
  中島健二　下濱俊　ら
- Total Pages
  907
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-23590607
[Book] Animal Models of Parkinson's Disease Induced by Toxins and Genetic Manipulation2012
- Author(s)
  Shin Hisahara, Shun Shimohama
- Publisher
  In Tech
- Data Source
  KAKENHI-PROJECT-21591096
[Book] Mechanisms in Parkinson's Disease-Models and Treatments2011
- Author(s)
  Shin Hisahara and Shun Shimohama
- Total Pages
  28
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Early detection of redox imbalance in the APPswe/PS1dE9 mouse model of Alzheimer’s disease by in vivo electron paramagnetic resonance imaging2021
- Author(s)
  Emoto Miho C.、Sato-Akaba Hideo、Hamaue Naoya、Kawanishi Katsuya、Koshino Hisashi、Shimohama Shun、Fujii Hirotada G.
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 172 Pages: 9-18
- DOI
  10.1016/j.freeradbiomed.2021.05.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07920, KAKENHI-PROJECT-20K07829, KAKENHI-PROJECT-23K20938
[Journal Article] Severe Mononeuritis Multiplex due to Rheumatoid Vasculitis in Rheumatoid Arthritis in Sustained Clinical Remission for Decades2020
- Author(s)
  Tanemoto Masanobu、Hisahara Shin、Hirose Bungo、Ikeda Kazuna、Matsushita Takashi、Suzuki Shuichiro、Manabe Tatsuo、Imai Tomihiro、Shimohama Shun
- Journal Title
  
  Intern. Med.
  
  Volume: 59 Issue: 5 Pages: 705-710
- DOI
  10.2169/internalmedicine.3866-19
- NAID
  130007804520
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2020-03-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07099
[Journal Article] CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway.2019
- Author(s)
  Fujikura M, Iwahara N, Hisahara S, Kawamata J, Matsumura A, Yokokawa K, Saito T, Manabe T, Matsushita T, Suzuki S, Shimohama S.
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 68 Issue: 1 Pages: 323-337
- DOI
  10.3233/jad-180904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05279, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-17K16388
[Journal Article] Clinical and Radiological Characteristics of Intracranial Artery Dissection Using Recently Proposed Diagnostic Criteria2019
- Author(s)
  Nakamura Y, Yamaguchi Y, Makita N, Morita Y, Ide T, Wada S, Mizoguchi T, Ikenouchi H, Miwa K, Yi K, Irie K, Shimohama S, Ihara M, Toyoda K, Koga M
- Journal Title
  
  J Stroke Cerebrovasc Dis
  
  Volume: Epub Issue: 6 Pages: 30063-1
- DOI
  10.1016/j.jstrokecerebrovasdis.2019.02.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09485, KAKENHI-PROJECT-16H05279, KAKENHI-PROJECT-17H04670
[Journal Article] Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease2019
- Author(s)
  Saito Taro、Hisahara Shin、Iwahara Naotoshi、Emoto Miho C.、Yokokawa Kazuki、Suzuki Hiromi、Manabe Tatsuo、Matsumura Akihiro、Suzuki Syuuichirou、Matsushita Takashi、Kawamata Jun、Sato-Akaba Hideo、Fujii Hirotada G.、Shimohama Shun
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 145 Pages: 20-32
- DOI
  10.1016/j.freeradbiomed.2019.09.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07920, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-17K16388
[Journal Article] Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress2019
- Author(s)
  Yokokawa Kazuki、Iwahara Naotoshi、Hisahara Shin、Emoto Miho C.、Saito Taro、Suzuki Hiromi、Manabe Tatsuo、Matsumura Akihiro、Matsushita Takashi、Suzuki Syuuichirou、Kawamata Jun、Sato-Akaba Hideo、Fujii Hirotada G.、Shimohama Shun
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 72 Issue: 3 Pages: 867-884
- DOI
  10.3233/jad-190817
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07920, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-17K16388
[Journal Article] Evaluation of Mitochondrial Oxidative Stress in the Brain of a Transgenic Mouse Model of Alzheimer's Disease by in vitro Electron Paramagnetic Resonance Spectroscopy.2019
- Author(s)
  Manabe T, Matsumura A, Yokokawa K, Saito T, Fujikura M, Iwahara N, Matsushita T, Suzuki S, Hisahara S, Kawamata J, Suzuki H, Emoto MC, Fujii HG, Shimohama S.
- Journal Title
  
  Journal of Alzheimer's disease
  
  Volume: 67 Issue: 3 Pages: 1079-1087
- DOI
  10.3233/jad-180985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-16H05279, KAKENHI-PROJECT-16K10291, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-17K16388
[Journal Article] Development of moyamoya disease after non-herpetic acute limbic encephalitis: A case report.2018
- Author(s)
  Takahashi Y, Mikami T, Suzuki H, Komatsu K, Yamamoto D, Shimohama S, Houkin K, Sugita S, Hasegawa T, Mikuni N.
- Journal Title
  
  J Clin Neurosci.
  
  Volume: 53 Pages: 250-253
- DOI
  10.1016/j.jocn.2018.04.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05279
[Journal Article] Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease.2018
- Author(s)
  Takata K., et al.
- Journal Title
  
  Neurobiol Aging
  
  Volume: 62 Pages: 197-209
- DOI
  10.1016/j.neurobiolaging.2017.10.021
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08286, KAKENHI-PROJECT-16H05279
[Journal Article] Fingolimod induces BAFF and expands circulating transitional B cells without activating memory B cells and plasma cells in multiple sclerosis2018
- Author(s)
  Miyazaki Yusei、Niino Masaaki、Takahashi Eri、Suzuki Masako、Mizuno Masanori、Hisahara Shin、Fukazawa Toshiyuki、Amino Itaru、Nakano Fumihito、Nakamura Masakazu、Akimoto Sachiko、Minami Naoya、Fujiki Naoto、Doi Shizuki、Shimohama Shun、Terayama Yasuo、Kikuchi Seiji
- Journal Title
  
  Clinical Immunology
  
  Volume: 187 Pages: 95-101
- DOI
  10.1016/j.clim.2017.10.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16H05279
[Journal Article] Establishing a New Screening System for Mild Cognitive Impairment and Alzheimer's Disease with Mental Rotation Tasks that Evaluate Visuospatial Function.2018
- Author(s)
  Suzuki A, Shinozaki J, Yazawa S, Ueki Y, Matsukawa N, Shimohama S, Nagamine T.
- Journal Title
  
  J Alzheimers Dis
  
  Volume: 61(4) Issue: 4 Pages: 1653-1665
- DOI
  10.3233/jad-170801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09355, KAKENHI-PROJECT-17K00207, KAKENHI-PROJECT-16H05279
[Journal Article] Effect of local cooling on excitation-contraction coupling in myasthenic muscle: Another mechanism of ice-pack test in myasthenia gravis.2017
- Author(s)
  Yamamoto D, Imai T, Tsuda E, Hozuki T, Yamauchi R, Hisahara S, Kawamata J, Shimohama S.
- Journal Title
  
  Clin Neurophysiol.
  
  Volume: 128 Issue: 11 Pages: 2309-2317
- DOI
  10.1016/j.clinph.2017.08.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09840
[Journal Article] Effects of a DJ-1-binding compound on spatial learning and memory impairment in a mouse model of Alzheimer's disease2017
- Author(s)
  Kitamura Y, Inden M, Kimoto K, Takata K, Yanagisawa D, Hijioka M, Ashihara K, Tooyama I, Shimohama S, Ariga H
- Journal Title
  
  Journal of Alzheimer’s Disease
  
  Volume: 55 Issue: 1 Pages: 67-72
- DOI
  10.3233/jad-160574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K16321, KAKENHI-PROJECT-16K08286, KAKENHI-PROJECT-16H05279
[Journal Article] Role of Suppressor of Cytokine Signaling 3 (SOCS3) in Altering Activated Microglia Phenotype in APPswe/PS1dE9 Mice.2017
- Author(s)
  Iwahara N, Hisahara S, Kawamata J, Matsumura A, Yokokawa K, Saito T, Fujikura M, Manabe T, Suzuki H, Matsushita T, Suzuki S, Shimohama S.
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 55 Issue: 3 Pages: 1235-1247
- DOI
  10.3233/jad-160887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09840, KAKENHI-PROJECT-16H05279
[Journal Article] Effects of a DJ-1-binding compound on spatial learning and memory impairment in a mouse model of Alzheimer disease2017
- Author(s)
  Kitamura Y, Inden M, Kimoto Y, Takata K, Yanagisawa D, Hijioka M, Ashihara E, Tooyama I, Shimohama S, Ariga H
- Journal Title
  
  Journal of Alzheimers Disease
  
  Volume: 55 Pages: 67-72
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05279
[Journal Article] Role of suppressor of cytokine signaling 3 (SOCS3) in altering activated microglia phenotype in APPswe/PS1dE9 mice2017
- Author(s)
  Iwahara n, Hisahara S, Kawamata J, Matsumura A, Yokokawa K, Saito T, Fujikura M, Manabe T, Suzuki H, Matsushita T, Suzuki S, Shimohama S
- Journal Title
  
  Journal of Alzheimers Disease
  
  Volume: 55 Pages: 1235-1247
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05279
[Journal Article] Progressive multifocal leukoencephalopathy after autologous peripheral blood stem cell transplantation in a patient with multiple myeloma treated with combination therapy2016
- Author(s)
  Yokokawa K, Hisahara S, Matsuura Y, Ikeda K, Tsuda E, Saitoh M, Nakamichi K, Saijo M, Kamihara Y, Sato T, Kawamata J, Shimohama S
- Journal Title
  
  Journal of Neurological Science
  
  Volume: 368 Pages: 304-306
- DOI
  10.1016/j.jns.2016.07.045
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05279, KAKENHI-PROJECT-26461286
[Journal Article] Inhibition of monocarboxylate transporter 1 suppresses the proliferation of glioblastoma stem cells.2016
- Author(s)
  Takada T, Takata K, Ashihara E.
- Journal Title
  
  J Physiol Sci
  
  Volume: 66 Pages: 74-81
- DOI
  10.1016/j.neuint.2016.02.008
- NAID
  40020922534
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461436, KAKENHI-PROJECT-26860058, KAKENHI-PROJECT-25460109, KAKENHI-PROJECT-16H05279, KAKENHI-PROJECT-15K16321
[Journal Article] Temporal Changes of CD68 and α7 Nicotinic Acetylcholine Receptor Expression in Microglia in Alzheimer’s Disease-Like Mouse Models2015
- Author(s)
  Akihiro Matsumura, Syuuichirou Suzuki, Naotoshi Iwahara, Shin Hisahara, Jun Kawamata, Hiromi Suzuki, Ayano Yamauchi, Kazuyuki Takata, Yoshihisa Kitamura and Shun Shimohama
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 44 Issue: 2 Pages: 409-423
- DOI
  10.3233/jad-141572
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24659352, KAKENHI-PROJECT-15K09840, KAKENHI-PROJECT-25460109
[Journal Article] Evaluation of oxidative stress in the brain of a transgenic mouse model of Alzheimer disease by in vivo electron paramagnetic resonance imaging.2015
- Author(s)
  Matsumura A, Emoto MC, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H,Yamauchi A, Sato-Akaba H, Fujii HG, Shimohama S.
- Journal Title
  
  Free Radic Biol Med.
  
  Volume: 85 Pages: 165-173
- DOI
  10.1016/j.freeradbiomed.2015.04.013
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09840, KAKENHI-PROJECT-15K19288, KAKENHI-PROJECT-26861008
[Journal Article] Treatment outcome of patients with cranial base lesions of unknown etiology: focusing on infectious cases with multiple cranial nerve disorders2013
- Author(s)
  松村晃寛　今井富裕　齊藤正樹　久原真　下濱俊
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 53 Issue: 1 Pages: 9-18
- DOI
  10.5692/clinicalneurol.53.9
- NAID
  130004505305
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590607
[Journal Article] Therapeutic effects of human mesenchymal and hematopoietic stem cells on rotenone-treated parkinsonian mice2013
- Author(s)
  Inden M, Takata K, Nishimura K, Kitamura Y, Ashihara E, Yoshimoto K, Ariga H, Honmou O, Shimohama S
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume: 91 Issue: 1 Pages: 62-72
- DOI
  10.1002/jnr.23128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390180, KAKENHI-PROJECT-23591404, KAKENHI-PROJECT-23659460, KAKENHI-PROJECT-24590222, KAKENHI-PROJECT-25460109
[Journal Article] 3-[(2,4-Dimethoxy)benzylidene]-anabasei nedihydrochloride protects against 6-hydroxydopamine-induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats2013
- Author(s)
  Suzuki S, Kawamata J, Matsushita T, Matsumura A, Hisahara S, Takata K, Kitamura Y, Kem W, Shimohama S
- Journal Title
  
  J Neurosci Res.
  
  Volume: 91(3) Issue: 3 Pages: 462-71
- DOI
  10.1002/jnr.23160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390180, KAKENHI-PROJECT-23659384, KAKENHI-PROJECT-23659460, KAKENHI-PROJECT-24659352, KAKENHI-PROJECT-25460109
[Journal Article] Copper enhances APP dimerization and promotes Abeta production2013
- Author(s)
  Noda Y, Asada M, Kubota M, Maesako M, Watanabe K, Uemura M, Kihara T, Shimohama S, Takahashi R, Kinoshita A, Uemura K
- Journal Title
  
  Neuroscience Letters
  
  Volume: 547 Pages: 10-15
- DOI
  10.1016/j.neulet.2013.04.057
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22390180, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23659460, KAKENHI-PUBLICLY-24111524
[Journal Article] 原因不明のまま治療開始した頭蓋内病変の予後　多発性脳神経障害を呈した感染症を中心に2013
- Author(s)
  松村晃寛、今井富裕、齊藤正樹、久原真、下濱俊
- Journal Title
  
  臨床神経学
  
  Volume: 53 Pages: 9-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590607
[Journal Article] 原因不明のまま治療開始した頭蓋底病変の予後～多発性脳神経障害を呈した感染症を中心に～2013
- Author(s)
  松村晃寛,今井富裕,齊藤正樹,久原真,下濱俊
- Journal Title
  
  臨床神経
  
  Volume: 53 Pages: 9-18
- NAID
  130004505305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590607
[Journal Article] Continuation of exercise is necessary to inhibit high fat diet-inducde β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice.2013
- Author(s)
  Masato Maesako, Kengo Uemura, Ayana Iwata, Masakazu Kubota, Kiwamu Watanabe, Maiko Uemura, Yasuha Noda, Megumi Asada-Utsugi, Takeshi Kihara, Ryosuke Takahashi, Shun Shimohama and Ayae Kinoshita.
- Journal Title
  
  PLos One
  
  Volume: 8 Issue: 9 Pages: e72796-e72796
- DOI
  10.1371/journal.pone.0072796
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J00221, KAKENHI-PROJECT-22390180, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23659460, KAKENHI-PUBLICLY-24111524
[Journal Article] Mesenchymal stem cells transmigrate across brain microvascular endothelial cell monolayers through transiently formed inter-endothelial gaps2011
- Author(s)
  Matsushita T, Kibayashi T, Katayama T, Yamashita Y, Suzuki S, Kawamata J, Honmou O, Minami M, Shimohama S
- Journal Title
  
  Neurosci Lett
  
  Volume: 502 Issue: 1 Pages: 41-45
- DOI
  10.1016/j.neulet.2011.07.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390180, KAKENHI-PROJECT-22790508, KAKENHI-PROJECT-23659028, KAKENHI-PROJECT-23659460
[Journal Article] Relationship between dysphagia and depressive states in patients with Parkinson's disease2011
- Author(s)
  Meng Han, Hirofumi Ohnishi, Michio Nonaka, Rika Yamauchi, Takayoshi Hozuki, Takashi Hayashi, Masaki Saitoh, Shin Hisahara, Tomihiro Imai, Shun Shimohama, Mitsuru Mori
- Journal Title
  
  Parkinson's Disease & Related Disorders
  
  Volume: 17 Pages: 437-439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Toxin-Induced and Genetic Animal Models of Parkinson's Disease2011
- Author(s)
  Shin Hisahara and Shun Shimohama
- Journal Title
  
  Parkinson's Disease
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Dopamine Receptors and Parkinson's Disease2011
- Author(s)
  Shin Hisahara, Shun Shimohama
- Journal Title
  
  International Journal of Medicinal Chemistry
  
  Volume: 2011 Pages: 1-16
- DOI
  10.1155/2011/403039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Toxin-Induced and Genetic Animal Models of Parkinson's Disease2011
- Author(s)
  Shin Hisahara, Shun Shimohama
- Journal Title
  
  Parkinson's Disease
  
  Volume: 2011 Pages: 951709-951709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Relationship between dysphagia and depressive states in patients with Parkinson's disease2011
- Author(s)
  Meng Han, Hirofumi Ohnishi, Michio Nonaka, Rika Yamauchi, Takayoshi Hozuki, Takashi Hayashi, Masaki Saitoh, Shin Hisehara, Tomihiro Imai, Shun Shimohama, Mitsuru Mori
- Journal Title
  
  Parkinson's Disease & Related Disorders
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Dopamine Receptors and Parkinson's Disease2011
- Author(s)
  Shin Hisahara and Shun Shimohama
- Journal Title
  
  International Journal of Medicinal Chemistry
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Correlation of bite force with excitation-contraction coupling time of the masseter in myasthenia gravis2010
- Author(s)
  Tsuda E, Imai T, Hozuki T, Yamauchi R, Saitoh M, Hisahara S, Yoshikawa H, Motomur M, Shimohama S
- Journal Title
  
  Clin Neurophysiol
  
  Volume: 121 Pages: 1051-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Response of serum carboxylated and undercarboxylated osteocalcin to risedronate monotherapy and combined therapy with vitamin K(2) in corticosteroid-treated patients : a pilot study2010
- Author(s)
  Hozuki T, Imai T, Tsuda E, Matsumura A, Yamamoto D, Toyoshima T, Suzuki S, Yamauchi R, Hayashi T, Hisahara S, Shimohama S
- Journal Title
  
  Intern Med
  
  Volume: 49 Pages: 371-6
- NAID
  130000251679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase : clues to a possible strategy for treating ALS.2007
- Author(s)
  Yamashita H, Kawamata J, Okawa K, Kanki R, Nakamizo T, Hatayama T, Yamanaka K, Takahashi R, Shimohama S.
- Journal Title
  
  J Neurochem. (Epub ahead of print)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590872
[Journal Article] Heat-snock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase : clues to a possible strategy for treating ALS2007
- Author(s)
  Yamashita H, Kawamata J, Ukawa K, Kanki R, Nakamizo T, Hatayama T, Yamanaka K, Takahashi R, Shimohama S
- Journal Title
  
  Journal of Neurochemistry Mar 30[Epub ahead of print]
- Data Source
  KAKENHI-PROJECT-17590872
[Journal Article] Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase : clues to a possible strategy for treating ALS.2007
- Author(s)
  Yamashita H, Kawamata J, Okawa K, Kanki R, Nakamizo T, Hatayama T, Yamanaka K, Takahashi R, Shimohama S
- Journal Title
  
  Journal of Neurochemistry Mar 30 [Epub ahead of print]
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590872
[Journal Article] Gluten sensitivity in Japanese patients with adult-onset cerebllar ataxia.2006
- Author(s)
  Ihara M, Makino F, Sawada H, Mezaki T, Mizutani K, Nakase H, Matsui M, Tomimoto H, Shimohama S.
- Journal Title
  
  Intern.Med. 45
  
  Pages: 135-140
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Journal Article] Gluten sensitivity in Japanese patients with adult-onset cerebellar ataxia2006
- Author(s)
  Ihara M, Makino F, Sawada H, Mezaki T, Mizutani K, Nakase H, Matsui M, Tomimoto H, Shimohama s.
- Journal Title
  
  Intern. Med. 45
  
  Pages: 135-140
- NAID
  130000076581
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Journal Article] p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly2005
- Author(s)
  Izumi Y, Sawada H, Sakka N, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A.
- Journal Title
  
  J. Neurosci. Res. 79
  
  Pages: 849-860
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Journal Article] Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats2005
- Author(s)
  Inden M, Kondo JI, Kitamura Y, Takata K, Nishimura K, Taniguchi T, Sawada H, Shimohama S.
- Journal Title
  
  J Pharmacol. Sci. 97
  
  Pages: 203-211
- NAID
  10025725946
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Journal Article] p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly.2005
- Author(s)
  Izumi Y, Sawada H, Sakka N, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A.
- Journal Title
  
  J.Nuerosci.Res. 79
  
  Pages: 849-860
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Journal Article] Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells.2005
- Author(s)
  Izumi Y, Sawada H, Yamamoto N, Kume T, Katsuki H, Shimohama S., Akaike A.
- Journal Title
  
  J.Neurosci.Res. 82
  
  Pages: 126-137
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Journal Article] Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons.2005
- Author(s)
  Kume T, Kawai Y, Yoshida K, Nakamizo T, Kanki R, Sawada H, Katsuki H, Shimohama S, Sugimoto H, Akaike A.
- Journal Title
  
  Neurosci.Lett. 382
  
  Pages: 126-137
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Journal Article] Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells2005
- Author(s)
  Izumi Y, Sawada H, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A.
- Journal Title
  
  J. Neurosci. Res. 82
  
  Pages: 126-137
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Journal Article] Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons2005
- Author(s)
  Kume T, KawaiY, Yoshida K, Nakamizo T, Kanki R, Sawada H, Katsuki H, Shimohama S, Sugimoto H, Akaike A.
- Journal Title
  
  Neurosci. Lett. 382
  
  Pages: 126-137
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Journal Article] Cocaine and phenyleplirine eye drop test for Parkinson disease.2005
- Author(s)
  Sawada H, Yamakawa K, Yamakado H, Hosokawa R, Ohba M, Miyamaoto K, Kawamura T, Shimohama S.
- Journal Title
  
  JAMA 293
  
  Pages: 932-934
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Journal Article] Stimulation of nicotinic acetylcholine receptors protects motor neurons.2005
- Author(s)
  Nkamizo T, Kawamata J, Yamashita H, Kanki R, Kihara T, Sawada H, Akaike A, Shimohama S.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 330
  
  Pages: 1285-1289
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Journal Article] Lewy小体型痴呆の生化学2005
- Author(s)
  澤田秀幸, 下濱俊
- Journal Title
  
  Cognition and Dementia 4
  
  Pages: 34-39
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Journal Article] Cocaine and phenylephrine eye drop test for Parkinson disease2005
- Author(s)
  Sawada H, Yamakawa K, Yamakado H, Hosokawa R, Ohba M, Miyamoto K, Kawamura T, Shimohama S.
- Journal Title
  
  JAMA 293
  
  Pages: 932-934
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Journal Article] Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats.2005
- Author(s)
  Inden M, Kondo JI, Kitamura Y, Takata K, Nishimura K, Taniguchi T, Sawada H, Shimohama S.
- Journal Title
  
  J.Pharmacol.Sci. 97
  
  Pages: 203-211
- NAID
  10025725946
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Journal Article] Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity.2004
- Author(s)
  Kihara T, Sawada H, Nakamizo T, Kanki R, Yamashita H, Maelicke A, Shimohama S.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 325
  
  Pages: 976-982
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Journal Article] Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity2004
- Author(s)
  Kihara T, Sawada H, Nakamizo T, Kanki R, Yamashita H, Maelicke A, Shimohama S.
- Journal Title
  
  Biochem Biophys Res Commun. 325
  
  Pages: 976-982
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590823
[Patent] パーキンソン病診断キット2003
- Inventor(s)
  澤田秀幸, 下濱俊
- Industrial Property Rights Holder
  関西TLO
- Industrial Property Number
  2003-405942
- Filing Date
  2003-12-04
- Data Source
  KAKENHI-PROJECT-16590823
[Presentation] Immunohistological study of immunocytes in 6-OHDA-induced lesion in a rat Parkinson's disease model.2020
- Author(s)
  鈴木秀一郎, 鈴木紘美、齋藤太郎、横川和樹、真部建郎、松下隆司、松村晃寛、久原真、下濱俊
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09783
[Presentation] Deacetylase SIRT1 and SIRT2 regulate cytoskeleton-related molecules in oligodendrocyte cell lines2019
- Author(s)
  Shin Hisahara， Naotoshi Iwahara， Tatsuo Manabe， Mai Fujikura， Taro Saito， Kazuki Yokokawa， Takashi Matsushita， Akihiro Matsumura， Syuuichirou Suzuki， Jun Kawamata， Shun Shimohama
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K07099
[Presentation] Rat Bone Marrow-derived MSCs Attenuate Oxidative Stress and Neuroinflammation in APP/PS1 mice2019
- Author(s)
  横川和樹, 岩原直敏, 江本美穂, 久原真, 齋藤太郎, 藤倉舞, 真部建郎, 松下隆司, 松村晃寛, 鈴木秀一郎, 川又純, 藤井博匡, 下濱俊
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K07099
[Presentation] Effectiveness of galantamine treatment in normal cognition phase of APPswe/PS1dE9 mice2019
- Author(s)
  齋藤太郎, 横川和樹, 藤倉舞, 眞部建郎, 岩原直敏, 久原真, 松村晃寛, 鈴木秀一郎, 松下隆司, 川又純, 鈴木紘美, 江本美穂, 藤井博匡, 下濱俊
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K07099
[Presentation] 神経変性疾患に対する脳血流123I-IMP-SPECTにおけるCIScore解析の検証2019
- Author(s)
  松村晃寛, 浅沼治, 横川和樹, 齋藤太郎, 藤倉舞, 岩原直敏, 眞部建郎, 津田玲子, 山本大輔, 松下隆司, 鈴木秀一郎, 臼井桂子, 齊藤正樹, 久原真, 川又純, 今井富裕, 下濱俊
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K07099
[Presentation] Time course of intranigral invasion of immunocytes in 6-OHDA-induced Parkinson's disease rat model2019
- Author(s)
  鈴木秀一郎, 鈴木紘美, 齋藤太郎, 横川和樹, 藤倉舞, 真部健郎, 岩原直敏, 松下隆司, 松村晃寛, 久原真, 川又純, 下濱俊
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K07099
[Presentation] Time course of intranigral invasion of immunocytes in 6-OHDA-induced Parkinson's disease rat model.2019
- Author(s)
  鈴木紘美、齋藤太郎、横川和樹、藤倉舞、真部健郎、岩原直敏、松下隆司、松村晃寛、久原真、川又純、下濱俊
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09783
[Presentation] CD14 and Toll-like receptor 4 promote fibrillar Aβ uptake by microglia through clathrin-mediated pathway.2018
- Author(s)
  Fujikura M, Shimohama S, et al.
- Organizer
  37th Annual Meeting of Japanese Society for Dementia Research
- Data Source
  KAKENHI-PROJECT-16H05279
[Presentation] The evaluation of mitochondrial Abeta accumulation and oxidative stress in APdE9 mice2018
- Author(s)
  Manabe T, Shimohama S, et al.
- Organizer
  59th Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-16H05279
[Presentation] APPswe/PS1dE9マウスにおけるガランタミンの超早期治療の有効性.2018
- Author(s)
  齋藤太郎，下濱俊ら.
- Organizer
  37th Annual Meeting of Japanese Society for Dementia Research
- Data Source
  KAKENHI-PROJECT-16H05279
[Presentation] The optimal preconditioning for bone marrow transplantation to establish 6-OHDA-lesioned GFP bone marrow chimeric PD model rat.2018
- Author(s)
  Syuuichirou Suzuki, Hiromi Suzuki, Taro Saito, Kazuki Yokokawa, Mai Fujikura, Tatsuo Manabe, Naotoshi Iwahara, Akihiro Matsumura, Takashi Matsushita, Shin Hisahara, Jun Kawamata, Miho Emoto, Shun Shimohama
- Organizer
  第23回世界神経学会議(WCN2017)
- Data Source
  KAKENHI-PROJECT-17K09783
[Presentation] Effectiveness of galantamine treatment in normal cognition phase of APPswe/PS1dE9 mice..2018
- Author(s)
  Saito T, Shimohama S, et al.
- Organizer
  59th Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-16H05279
[Presentation] 脳血流IMP-SPECTにおけるCIScore解析によるDLB・AD鑑別の検証.2018
- Author(s)
  松村晃寛，下濱俊ら.
- Organizer
  37th Annual Meeting of Japanese Society for Dementia Research
- Data Source
  KAKENHI-PROJECT-16H05279
[Presentation] アルツハイマー病モデルマウスにおける骨髄間葉系幹細胞治療のメカニズム検討.2018
- Author(s)
  横川和樹，下濱俊ら.
- Organizer
  37th Annual Meeting of Japanese Society for Dementia Research
- Data Source
  KAKENHI-PROJECT-16H05279
[Presentation] Involvement of SIRTs in the morphological change of human oligodendrocyte cell lines2018
- Author(s)
  Shin Hisahara， Naotoshi Iwahara， Tatsuo Manabe， Mai Fujikura， Taro Saito， Kazukia Yokokawa， Naoki Gamo， Takashi Matsushita， Matsumura Akihiro， Syuuichirou Suzuki， Jun Kawamata， Shun Shimohama
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K07099
[Presentation] Temporal changes of CD14 expression in APdE9 mice.2018
- Author(s)
  Fujikura M, Shimohama S, et al.
- Organizer
  59th Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-16H05279
[Presentation] Rat Bone Marrow-derived MSC Improve Oxidative Stress in Alzheimer's Disease Mouse Mode.2018
- Author(s)
  Yokokawa K, Shimohama S, et al.
- Organizer
  59th Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-16H05279
[Presentation] Intracerebral infiltration of immune cells in 6-OHDA-induced Parkinson's disease model rat.2018
- Author(s)
  鈴木秀一郎、鈴木紘美、蒲生直希、齋藤太郎、横川和樹、藤倉舞，真部建郎、岩原直敏、松村晃寛、松下隆司、久原真、川又純、下濱俊
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09783
[Presentation] アルツハイマー病モデルマウスでは早期にミトコンドリアで酸化ストレスが増大する.2018
- Author(s)
  真部達郎，下濱俊ら.
- Organizer
  37th Annual Meeting of Japanese Society for Dementia Research
- Data Source
  KAKENHI-PROJECT-16H05279
[Presentation] THE OPTIMAL PRECONDITIONING FOR BONE MARROW TRANSPLANTATION TO ESTABLISH 6-OHDA-LESIONED GFP BONE MARROW CHIMERIC PD MODEL RAT.2017
- Author(s)
  S Suzuki, H Suzuki, K Yokokawa,T Saito, M Fujikura, T Manabe, N Iwahara, A Matsumura, T Matsushita, S Hisahara, J Kawamata, S Shimohama
- Organizer
  World Congress of Neurology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09783
[Presentation] Deacetylase SIRTs regulate differentiation of oligodendrocyte and modulate distribution of oligodendrocyte-specific cytoskeleton-related molecules2017
- Author(s)
  Shin Hisahara, Naotoshi Iwahara, Tatsuo Manabe, Mai Fujikura, Taro Saito, Kazuki Yokokawa, Akihiro Matsumura, Syuuichirou Suzuki, Jun Kawamata, Shun Shimohama
- Organizer
  23rd Annual Meeting of World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07099
[Presentation] Stimulation of nicotinic acetylcholine receptor suppresses expression of CD14 in microglia.2017
- Author(s)
  Fujikura M, Shimohama S, et al.
- Organizer
  The XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05279
[Presentation] Early Aβ accumulation in the mitochondria produces oxidative stress and Induces neurodegeneration in APDE9 mice.2017
- Author(s)
  Manabe T, Shimohama S, et al.
- Organizer
  The XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05279
[Presentation] Efficacy of galantamine treatment in very early stage of APPSWE/PS1DE9 mice.2017
- Author(s)
  Saito T, Shimohama S, et al.
- Organizer
  The XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05279
[Presentation] Decision making of using invasive mechanical ventilation in patients with amyotrophic lateral sclerosis in Sapporo area2017
- Author(s)
  J. Kawamata, D. Yamamoto, T. Matsushita, A. Matsumura, S. Suzuki, S. Hisahara, S. Shimohama, E. Tsuda, R. Yamauchi
- Organizer
  XXIII World Congress of Neurology WCN2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09840
[Presentation] Cytosolic SIRT3 Protects PC12 cells against amyloid beta toxicity.2017
- Author(s)
  Matsushita T, Shimohama S, et al.
- Organizer
  The XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05279
[Presentation] Transplantation of Rat bone marrow-derived mesenchymal stem cells regulates oxidative stress in alzheimer’s disease transgenic mouse model.2017
- Author(s)
  Yokokawa K, Shimohama S, et al.
- Organizer
  The XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05279
[Presentation] 地域包括支援センターが展開する介護福祉従事者に対するAct-F.A.S.T.講習の効果2014
- Author(s)
  白戸史子、齊藤正樹、永川ひとみ、佐藤美雪、下濱俊
- Organizer
  日本脳卒中学会総会
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] 非弁膜症性心房細動に伴う脳梗塞急性期における新規経口抗凝固薬投与の可否に関する検討2014
- Author(s)
  外山祐一郎、矢坂正弘、前田亘一郎、桑城貴弘、湧川佳幸、齊藤正樹、下濱俊、岡田靖
- Organizer
  第39回日本脳卒中学会総会
- Place of Presentation
  大阪市
- Year and Date
  2014-03-13
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] 介護福祉従事者の参加する中学・高校生に対するAct-F.A.S.T.救急講習会2014
- Author(s)
  大畑雅宏　齊藤正樹　山崎友敬、中村英保、山水輝彦、福士敦、小林茂樹、外山祐一郎、下濱俊
- Organizer
  日本脳卒中学会総会
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] 地域包括支援センターが展開する介護従事者に対するAct-F.A.S.T.講習の効果2014
- Author(s)
  白戸史子齊藤正樹永川ひとみ佐藤美雪下濱俊
- Organizer
  第39回日本脳卒中学会総会
- Place of Presentation
  大阪市
- Year and Date
  2014-03-14
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] 介護福祉従事者の参加する中学・高校生に対するAct-F.A.S.T.救急講習会2014
- Author(s)
  大畑雅宏齊藤正樹山崎友敬中村英保山水輝彦福士敦小林茂樹外山祐一郎下濱俊
- Organizer
  第39回日本脳卒中学会総会
- Place of Presentation
  大阪市
- Year and Date
  2014-03-14
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] NIH Stroke Scale　(NIHSS)　医学部卒業実技試験2013
- Author(s)
  齊藤正樹　山本和利　米増保之　橋本　諭　佐々木素子　瀬上朋宏　三上　毅　寳金清博　三國信啓　下濱　俊
- Organizer
  第38回日本脳卒中学会総会
- Place of Presentation
  東京　品川
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] NIH Stroke Scale(NIHSS)医学部卒業実技試験5年間502名の結果報告第二報―苦手なスコアはなぜ生じるのか―2013
- Author(s)
  齊藤正樹山本和利米増保之櫛引晴子伊藤郁子加藤和彦小松克也杉野寿哉村上友宏外山祐一郎鈴木秀一郎松村晃寛三上毅三國信啓矢坂正弘岡田靖寳金清博下濱俊
- Organizer
  第45回北海道脳卒中研究会
- Place of Presentation
  札幌市
- Year and Date
  2013-06-29
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] 介護福祉従事者への脳卒中研修会による地域の人材育成と中学生・高校生の脳卒中教育2013
- Author(s)
  齊藤正樹大畑雅宏及川佑介福士敦山水輝彦山崎友敬岡田靖矢坂正弘下濱俊
- Organizer
  第38回日本脳卒中学会総会
- Place of Presentation
  東京都
- Year and Date
  2013-03-21
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] おひとりさま講習会参加者における認知症の理解2013
- Author(s)
  齊藤正樹川又純下濱俊
- Organizer
  第32回日本認知症学会総会
- Place of Presentation
  松本市
- Year and Date
  2013-11-08
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] NIH Stroke Scale(NIHSS)医学部卒業実技試験5年間502名の結果報告2013
- Author(s)
  齊藤正樹山本和利米増保之橋本諭佐々木素子瀬上朋宏三毅寳金清博三國信啓下濱俊
- Organizer
  第38回日本脳卒中学会総会
- Place of Presentation
  東京都
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] 脳卒中研修会により育成された地域介護福祉人材による中学生・高校生の脳卒中教育2013
- Author(s)
  齊藤正樹大畑雅宏福士敦山水輝彦山崎友敬白戸史子後藤みゆき稲見保之佐々木いつみ川口和代矢坂正弘岡田靖下濱俊
- Organizer
  第45回北海道脳卒中研究会
- Place of Presentation
  札幌市
- Year and Date
  2013-06-29
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] 介護福祉従事者への脳卒中研修会による2013
- Author(s)
  齊藤　正樹　大畑　雅宏　及川佑介　福士　敦　山水　輝彦　山崎　友敬　岡田　靖　矢坂　正弘　下濱　俊
- Organizer
  第38回日本脳卒中学会総会
- Place of Presentation
  東京　品川
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] Development of an in vitro imaging system for the study of the mechanisms underlying mesenchymal stem cell transmigration across the blood brain barrier2012
- Author(s)
  木林達也, 片山貴博, 松下隆司, 永井健治, 下濱俊, 南雅文
- Organizer
  第55回日本神経化学会大会
- Place of Presentation
  神戸国際会議場(兵庫)
- Data Source
  KAKENHI-PROJECT-22390180
[Presentation] Mesenchymal stem cells transmigrate across the blood-brain barrier through transiently formed interendothelial gaps2012
- Author(s)
  片山貴博, 木林達也, 松下隆司, 本望修, 下濱俊, 南雅文
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  国立京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-22390180
[Presentation] Development of an in vitro imaging system for the study of the mechanisms underlying mesenchymal stem cell transmigration across the blood brain barrier2012
- Author(s)
  木林達也、片山貴博、松下隆司、永井健治、下濱俊、南雅文
- Organizer
  第55回日本神経化学会大会
- Place of Presentation
  神戸国際会議場(兵庫)
- Data Source
  KAKENHI-PROJECT-23659460
[Presentation] Mesenchymal stem cells transmigrate across the blood-brain barrier through transiently formed interendothelial gaps2012
- Author(s)
  片山貴博、木林達也、松下隆司、本望修、下濱俊、南雅文
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  国立京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-23659460
[Presentation] 認知症介護スタッフの服薬介助に対する困難感と剤型選択第二報勤務背景の違いによる検討2012
- Author(s)
  齊藤正樹川又純下濱俊
- Organizer
  第31回日本認知症学会総会
- Place of Presentation
  つくば市
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] 認知症介護スタッフにおける服薬介助における困難感と剤形選択第二報2012
- Author(s)
  齊藤正樹　川又純　下濱俊
- Organizer
  第31回日本認知症学会総会
- Place of Presentation
  つくば市
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] 介護福祉スタッフへのACT-F.A.S.T.脳卒中研修と市民啓発は地域の脳卒中患者の来院までの時間を短縮する2012
- Author(s)
  齊藤正樹及川佑介大畑雅宏米増保之高橋明岡田靖矢坂正弘姉川敬裕吉田英人下濱俊
- Organizer
  第37回日本脳卒中学会総会シンポジウム
- Place of Presentation
  福岡市
- Year and Date
  2012-04-28
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] In vitro 血液脳関門モデルを用いた骨髄間葉系幹細胞の動態解析2011
- Author(s)
  木林達也、松下隆司、片山貴博、下濱俊、南雅文
- Organizer
  第62回日本薬理学会北部会
- Place of Presentation
  江陽グランドホテル(宮城)
- Data Source
  KAKENHI-PROJECT-23659460
[Presentation] In vitro 血液脳関門モデルを用いた骨髄間葉系幹細胞の動態解析2011
- Author(s)
  木林達也, 松下隆司, 片山貴博, 下濱俊, 南雅文
- Organizer
  第62回日本薬理学会北部会
- Place of Presentation
  江陽グランドホテル(宮城)
- Data Source
  KAKENHI-PROJECT-22390180
[Presentation] Mesenchymal stem cells transmigrate across brain microvascular endothelial cell monolayers through transiently formed interendothelial gaps2011
- Author(s)
  片山貴博, 松下隆司, 木林達也, 本望修, 下濱俊, 南雅文
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  ホテル瑠璃光(石川)
- Data Source
  KAKENHI-PROJECT-22390180
[Presentation] Mesenchymal stem cells transmigrate across brain microvascular endothelial cell monolayers through transiently formed interendothelial gaps2011
- Author(s)
  片山貴博、松下隆司、木林達也、本望修、下濱俊、南雅文
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  ホテル瑠璃光(石川)
- Data Source
  KAKENHI-PROJECT-23659460
[Presentation] 認知症介護スタッフの服薬介助に対する困難感と剤型選択による服薬アドヒアランス改善の可能性2011
- Author(s)
  齊藤正樹川又純下濱俊
- Organizer
  第30回日本認知症学会総会
- Place of Presentation
  東京都
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23590607
[Presentation] Resver atrolによる神経系細胞における酸化ストレス耐性の検討2010
- Author(s)
  久原真、堀尾嘉幸、下濱俊
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-21591096
[Presentation] Resveratrolによる神経系細胞における酸化ストレス耐性の検討2010
- Author(s)
  久原真、堀尾嘉幸、下濱俊
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-21591096
[Presentation] 培養神経幹細胞における分化特性とヒストン脱アセチル化酵素SIRT1の関与2009
- Author(s)
  久原真、堀尾嘉幸、下濱俊
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-21591096
[Presentation] Histone deacetylase SIRT1 modulates neuronal differentiation2009
- Author(s)
  S. Hisahara, M. Tanno, S. Shimohama, M. Sato, Y. Horio
- Organizer
  Annual Meeting of Society for Neuroscience
- Place of Presentation
  アメリカ合衆国・シカゴ
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-21591096
[Presentation] 脱アセチル化酵素SIRTの培養オリゴデンドロサイト分化制御における関与の検討
- Author(s)
  久原　真、鈴木秀一郎、松村晃寛、林　貴士、齊藤正樹、今井富裕、下濱　俊
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-23659460
[Presentation] コリン仮説に基づくAD治療法開発の現状と展望
- Author(s)
  下濱　俊
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-22390180
[Presentation] 脱アセチル化酵素SIRTの培養オリゴデンドロサイト分化制御における関与の検討
- Author(s)
  久原　真、鈴木秀一郎、松村晃寛、林　貴士、齊藤正樹、川又　純、今井富裕、下濱　俊
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-22390180
[Presentation] コリン仮説に基づくAD治療法開発の現状と展望
- Author(s)
  下濱　俊
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-23659460
[Presentation] マウス培養ミクログリアにおけるアセチルコリンおよびグルタミン酸受容体の発現
- Author(s)
  岩原直敏、鈴木秀一郎、松村晃寛、久原　真、川又　純、下濱　俊
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際センター
- Data Source
  KAKENHI-PROJECT-22390180
[Presentation] パーキンソン病モデルラットに対する選択的α7ニコチン性受容体作動薬による神経保護作用
- Author(s)
  鈴木秀一郎、鈴木宏美、大橋乃理子、松村晃寛、久原　真、川又　純、下濱　俊、高田和幸、北村佳久
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-22390180
[Presentation] マウス培養ミクログリアにおけるアセチルコリンおよびグルタミン酸受容体の発現
- Author(s)
  岩原直敏、鈴木秀一郎、松村晃寛、久原　真、川又　純、下濱　俊
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際センター
- Data Source
  KAKENHI-PROJECT-23659460
[Presentation] パーキンソン病モデルラットに対する選択的α7ニコチン性受容体作動薬による神経保護作用
- Author(s)
  鈴木秀一郎、鈴木宏美、大橋乃理子、久原　真、川又　純、下濱　俊、高田和幸、北村佳久
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-23659460
[Presentation] アルツハイマー病トランスジェニックマウスモデルにおける脳内グリア細胞の動態解析
- Author(s)
  松村晃寛、鈴木宏美、大橋乃理子、鈴木秀一郎、山内理香、林　貴士、齊藤正樹、久原　真、川又　純、今井富裕、下濱　俊、佐々木祐典、本望　修、三國信啓、高田和幸、北村佳久
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-23659460
[Presentation] アルツハイマー病トランスジェニックマウスモデルにおける脳内グリア細胞の動態解析
- Author(s)
  松村晃寛、鈴木宏美、大橋乃理子、鈴木秀一郎、山内理香、林　貴士、齊藤正樹、久原　真、川又　純、今井富裕、下濱　俊、佐々木祐典、本望　修、三國信啓、高田和幸、北村佳久
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-22390180
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Shimohama Shun 下濱 俊

SHIMOHAMA Syun 下濱 俊

SHIMOHAMA Shun 下濱 俊

下浜 俊 シモハマ シユン

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Regulation of oxidative stress in Alzheimer model mice and its application for treatmentPrincipal Investigator

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Pathophysiological analysis for the ischemic brain damage using in vitro blood-brain barrier systemPrincipal Investigator

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Basic reserach for developing a new therapy by transplantation of mesenchymal stem cells against neurodegenerative diseasesPrincipal Investigator

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筋萎縮性側索硬化症治療薬としての分子シャペロン誘導剤の探索研究Principal Investigator

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アルツハイハー病におけるシナプス変性・脱落メカニズムの分子基盤の解明Principal Investigator

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Shimohama Shun 下濱俊

SHIMOHAMA Syun 下濱俊

SHIMOHAMA Shun 下濱俊

下浜俊シモハマシユン