Takeda Hiroshi 武田宏司

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TAKEDA Hiroshi 武田宏司

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Researcher Number	60261294
Other IDs
External Links
Affiliation (Current)	2025: 北海道大学, 薬学研究院, 名誉教授
Affiliation (based on the past Project Information) *help	2021 – 2022: 北海道大学, 薬学研究院, 名誉教授 2020: 北海道大学, 薬学研究院, 特任教授 2017 – 2019: 北海道大学, 薬学研究院, 教授 2015: 北海道大学, 薬学研究院臨床病態解析学, 教授 2012 – 2015: 北海道大学, 薬学研究科(研究院), 教授 … More 2010 – 2012: 北海道大学, 大学院・薬学研究院, 教授 2007: Hokkaido University, Graduate schcol of medicine, Associate Professor 2006: 北海道大学, 大学院医学研究科, 助教授 1998: Medical Hospital, Hokkaido University, Instructor, 医学部・附属病院, 講師 1997 – 1998: 北海道大学, 医学部附属病院, 講師 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 38050:Food sciences-related / Social dentistry / Gastroenterology
Keywords	Principal Investigator グレリン受容体 / H.pylori / MIF / 六君子湯 / グレリン / サーチュイン / PLA2G16 / 消化器癌 / parital cell / 壁細胞 … More / 食欲 / 漢方薬 / GOAT / グレリン・漢方 … More Except Principal Investigator マクロファージ遊走阻止因子 / 大腸癌 / 大腸炎 / 炎症性発癌 / 大腸腫瘍 / 炎症 / クロロゲン酸 / コーヒーポリフェノール / rehabilitation / aging / immunology / social medicine / dentistry / リハビリテーション / 老化 / 免疫学 / 社会医学 / 歯学 / 肝線維化 / 非アルコール性脂肪肝炎 / アセトアミノフェン / コリン・メチオニン欠損食 / 薬剤性肝障害 / 非アルコール性脂肪性肝炎 Less

Do sirtuins contribute to the anti-inflammatory effects of ghrelin?Principal Investigator
- Principal Investigator
  
  Takeda Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hokkaido University
Does coffee polyphenol inhibit the level of MIF and the development of inflammatory carcinogenesis.
- Principal Investigator
  
  Ohkawara Tatsuya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Hokkaido University
Role of novel ghrelin receptor binding protein PLA2G16 in gastrointestinal cancer cellsPrincipal Investigator
- Principal Investigator
  
  Takeda Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
Rikkunshito increased hypothalamic SIRT1 activityPrincipal Investigator
- Principal Investigator
  
  TAKEDA Hiroshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
Role of Macrophage migration inhibitory factor in non-alcoholic steatohepatitis
- Principal Investigator
  
  OHKAWARA Tatsuya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
The mechanism by which rikkunshito increases acylated ghrelinPrincipal Investigator
- Principal Investigator
  
  TAKEDA Hiroshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
Immunologcal effect of professional oral health care on the elderly requiring long-term care
- Principal Investigator
  
  INOUE Nobuo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  Hokkaido University
Helicobacter pylori and its association with gastric cancerPrincipal Investigator
- Principal Investigator
  
  TAKEDA Hiroshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  HOKKAIDO UNIVERSITY

All 2022 2021 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Decline in Liver Mitochondria Metabolic Function Is Restored by Hochuekkito Through Sirtuin 1 in Aged Mice With Malnutrition.2022
- Author(s)
  Nahata M, Fujitsuka N, Sekine H, Shimobori C, Ohbuchi K, Iizuka S, Mogami S, Ohnishi S, Takeda H.
- Journal Title
  
  Front Physiol.
  
  Volume: 13 Pages: 848960-848960
- DOI
  10.3389/fphys.2022.848960
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08348
[Journal Article] Role of Mitochondrial Dysfunction in the Pathogenesis of Cisplatin-Induced Myotube Atrophy2022
- Author(s)
  Matsumoto C, Sekine H, Nahata M, Mogami S, Ohbuchi K, Fujitsuka N, Takeda H.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 6 Pages: 780-792
- DOI
  10.1248/bpb.b22-00171
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-06-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08348
[Journal Article] Protective effect of ISO-1 with inhibition of RIPK3 up-regulation and neutrophilic accumulation on acetaminophen-induced liver injury in mice2021
- Author(s)
  Ohkawara Tatsuya、Okubo Naoto、Maehara Osamu、Nishihira Jun、Takeda Hiroshi
- Journal Title
  
  Toxicology Letters
  
  Volume: 339 Pages: 51-59
- DOI
  10.1016/j.toxlet.2020.12.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05500, KAKENHI-PROJECT-18H02997
[Journal Article] Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines2019
- Author(s)
  Maehara Osamu、Ohnishi Shunsuke、Asano Ayaka、Suda Goki、Natsuizaka Mitsuteru、Nakagawa Koji、Kobayashi Masanobu、Sakamoto Naoya、Takeda Hiroshi
- Journal Title
  
  Neoplasia
  
  Volume: 21 Issue: 6 Pages: 545-556
- DOI
  10.1016/j.neo.2019.03.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07959, KAKENHI-PROJECT-17K09344
[Journal Article] The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds.2018
- Author(s)
  Tanaka H, Watanabe A, Konishi M, Nakai Y, Yoshioka H, Ohkawara T, Takeda H, Harashima H, Akita H.
- Journal Title
  
  Heliyon
  
  Volume: 4 Issue: 12 Pages: e00959-e00959
- DOI
  10.1016/j.heliyon.2018.e00959
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05500, KAKENHI-PROJECT-18K18377, KAKENHI-PROJECT-17K19473
[Journal Article] Psychological stress in aged female mice causes acute hypophagia independent of central serotonin 2C receptor activation.2017
- Author(s)
  Matsumoto C, Yamada C, Sadakane C, Nahata M, Hattori T, Takeda H.
- Journal Title
  
  PLoS One.
  
  Volume: 12 Issue: 11 Pages: e0187937-e0187937
- DOI
  10.1371/journal.pone.0187937
- NAID
  120006369342
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09344
[Journal Article] Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1.2016
- Author(s)
  Fujitsuka N, Asakawa A, Morinaga A, Amitani MS, Amitani H, Katsuura G, Sawada Y, Sudo Y, Uezono Y, Mochiki E, Sakata I, Sakai T, Hanazaki K, Yada T, Yakabi K, Sakuma E, Ueki T, Niijima A, Nakagawa K, Okubo N, Takeda H, Asaka M, Inui A.
- Journal Title
  
  Mol Psychiatry
  
  Volume: 21 Issue: 11 Pages: 1-11
- DOI
  10.1038/mp.2015.220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15554, KAKENHI-PROJECT-25460922, KAKENHI-PROJECT-15K15277, KAKENHI-PLANNED-25117008, KAKENHI-PROJECT-15H04273, KAKENHI-PROJECT-26462244, KAKENHI-PROJECT-15K08686, KAKENHI-PROJECT-16K10220
[Journal Article] A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction.2015
- Author(s)
  Saegusa Y, Hattori T, Nahata M, Yamada C, Takeda H.
- Journal Title
  
  Evid Based Complement Alternat Med.
  
  Volume: 2015 Pages: 364260-364260
- DOI
  10.1155/2015/364260
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460922
[Journal Article] Herbal medicines for the treatment of cancer chemotherapy-induced side effects.2015
- Author(s)
  Ohnishi S, Takeda H.
- Journal Title
  
  Front Pharmacol
  
  Volume: 6 Pages: 14-14
- DOI
  10.3389/fphar.2015.00014
- NAID
  120005773990
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460922
[Journal Article] Serotonin 2C receptor contributes to gender differences in stress-induced hypophagia in aged mice.2015
- Author(s)
  Yamada C, Sadakane C, Nahata C, Saegusa Y, Nakagawa K, Okubo N, Ohnishi S, Hattori T, Takeda H
- Journal Title
  
  Psychoneuroendocrinology
  
  Volume: 55 Pages: 81-93
- DOI
  10.1016/j.psyneuen.2015.02.006
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24792149, KAKENHI-PROJECT-25460922
[Journal Article] Gender Differences on Feeding Behavior and Ghrelin-Related Factors during Social Isolation in Mice.2015
- Author(s)
  Yamada C, Saegusa Y, Nahata M, Sadakane C, Hattori T, Takeda H.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 10 Pages: e0140094-e0140094
- DOI
  10.1371/journal.pone.0140094
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460922
[Journal Article] Administration of exogenous acylated ghrelin or rikkunshito, an endogenous ghrelin enhancer, improves the decrease in postprandial gastric motility in an acute restraint stress mouse model.2014
- Author(s)
  Nahata M, Saegusa Y, Sadakane C, Yamada C, Nakagawa K, Okubo N, Ohnishi S, Hattori T, Sakamoto N, Takeda H.
- Journal Title
  
  Neurogastroenterol Motil
  
  Volume: 26 Issue: 6 Pages: 821-831
- DOI
  10.1111/nmo.12336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460922
[Journal Article] Clinical characteristics of elderly patients with proton pump inhibitor-refractory non-erosive reflux disease from the G-PRIDE study who responded to rikkunshito.2014
- Author(s)
  Sakata Y, Tominaga K, Kato M, Takeda H, Shimoyama Y, Takeuchi T, Iwakiri R, Furuta K, Sakurai K, Odaka T, Kusunoki H, Nagahara A, Iwakiri K, Furuta T, Murakami K, Miwa H, Kinoshita Y, Haruma K, Takahashi S, Watanabe S, Higuchi K, Fujimoto K, Kusano M, Arakawa T; G-PRIDE study group.
- Journal Title
  
  BMC Gastroenterol
  
  Volume: 14 Issue: 1 Pages: 116-116
- DOI
  10.1186/1471-230x-14-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460922
[Journal Article] Effects of Rikkunshito (traditional Japanese medicine) on enteral feeding and the plasma ghrelin level in critically ill patients: a pilot study.2014
- Author(s)
  Hayakawa M, 他6名
- Journal Title
  
  Journal of Intensive Care
  
  Volume: 2 Issue: 1 Pages: 53-53
- DOI
  10.1186/s40560-014-0053-4
- NAID
  120005595707
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293364, KAKENHI-PROJECT-25460922, KAKENHI-PROJECT-25462809
[Journal Article] Pathophysiological basis of anorexia.2013
- Author(s)
  Takeda H, Muto S, Nakagawa K, Ohnishi S, Sadakane C, Saegusa Y, Nahata M, Hattori T, Asaka M.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 36 Pages: 1401-1405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460922
[Journal Article] Serotonin 2Creceptor antagonism ameliorates novelty- induced hypophagia in aged mice.2013
- Author(s)
  Nahata M, Muto S, Nakagawa K, Ohnishi S, Sadakane C, Saegusa Y, Iizuka S, Hattori T, Asaka M, Takeda H.
- Journal Title
  
  Psychoneuroendocrinology.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590676
[Journal Article] Cisplatin-induced anorexia and ghrelin.2013
- Author(s)
  Hattori T, Yakabi K, Takeda H.
- Journal Title
  
  Vitam Horm
  
  Volume: 92 Pages: 301-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590676
[Journal Article] Serotonin 2C receptor antagonism ameliorates novelty-induced hypophagia in aged mice.2013
- Author(s)
  Nahata M, Muto S, Nakagawa K, Ohnishi S, Sadakane C, Saegusa Y, Iizuka S, Hattori T, Asaka M, Takeda H.
- Journal Title
  
  Psychoneuroendocrinology.
  
  Volume: 38 Issue: 10 Pages: 2051-2064
- DOI
  10.1016/j.psyneuen.2013.03.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460922
[Journal Article] Comparison of Gastric Relaxation and Sensory Functions between Functional Dyspepsia and Healthy Subjects Using Novel Drinking-Ultrasonography Test.2013
- Author(s)
  Hata T, Kato M, Kudo T, Nishida M, Nishida U, Imai A, Yoshida T, Hirota J, Kamada G, Ono S, Nakagawa M, Nakagawa S, Shimizu Y, Takeda H, Asaka M.
- Journal Title
  
  Digestion.
  
  Volume: 87 Pages: 34-39
- NAID
  120005228164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590676
[Journal Article] Cisplatin-induced anorexia and ghrelin.2013
- Author(s)
  Hattori T, Yakabi K, Takeda H.
- Journal Title
  
  Vitam Horm.
  
  Volume: 92 Pages: 301-317
- DOI
  10.1016/b978-0-12-410473-0.00012-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460922
[Journal Article] Changes in ghrelin-related factors in gastroesophageal reflux disease in rats.2013
- Author(s)
  Nahata M, Saegusa Y, Harada Y, Tsuchiya N, Hattori T, Takeda H.
- Journal Title
  
  Gastroenterology Research and Practice.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590676
[Journal Article] Impaired ghrelin signaling is associated with gastrointestinal dysmotility in rats with gastroesophageal reflux disease.2012
- Author(s)
  Nahata M, Muto S, Oridate N, Ohnishi S, Nakagawa K, Sadakane C, Saegusa Y, Hattori T, Asaka M, Takeda H.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol.
  
  Volume: 303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590676
[Journal Article] Efficacy of carbon dioxide-insufflating colonoscopy in patients with irritable bowel syndrome (IBS): a randomized double-blind study.2012
- Author(s)
  Imai A, Kato M, Ono S, Shimizu Y, Takeda H, Asaka M.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 27 Pages: 1623-1628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590676
[Journal Article] Rikkunshito as a ghrelin enhancer.2012
- Author(s)
  Takeda H, Muto S, Nakagawa K, Ohnishi S, Sadakane C, Saegusa Y, Nahata M, Hattori T, Asaka M.
- Journal Title
  
  Methods Enzymol.
  
  Volume: 514 Pages: 333-351
- Data Source
  KAKENHI-PROJECT-22590676
[Journal Article] Rikkunshito and ghrelin secretion.2012
- Author(s)
  Takeda H, Muto S, Nakagawa K, Ohnishi S, Asaka M.
- Journal Title
  
  Curr Pharm Des.
  
  Volume: 18 Pages: 4827-4838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590676
[Journal Article] 10-Gingerol, a component of rikkunshito, improves cisplatin -induced anorexia by inhibiting acylated ghrelin degradation.2011
- Author(s)
  Sadakane C, Muto S, Nakagawa K, Ohnishi S, Saegusa Y, Nahata M, Hattori T, Asaka M, Takeda H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 412 Pages: 506-511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590676
[Journal Article] 10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation2011
- Author(s)
  Sadakane C, Muto S, Nakagawa K, Ohnishi S, Saegusa Y, Nahata M, Hattori T, Asaka M, Takeda H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 412 Issue: 3 Pages: 506-511
- DOI
  10.1016/j.bbrc.2011.08.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590676
[Journal Article] Decreased plasma ghrelin contributes to anorexia following novelty stress2011
- Author(s)
  Saegusa Y, Takeda H, Muto S, Nakagawa K, Ohnishi S, Sadakane C, Nahata M, Hattori T, Asaka M
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 301 Issue: 4 Pages: E685-E696
- DOI
  10.1152/ajpendo.00121.2011
- NAID
  130004626089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590676
[Journal Article] Decreased plasma ghrelin contributes to anorexia following novelty stress.2011
- Author(s)
  Saegusa Y, Takeda H, Muto S, Nakagawa K, Ohnishi S, Sadakane C, Nahata M, Hattori T, Asaka M.
- Journal Title
  
  Am J Physiol Endocrinol Metab.
  
  Volume: 301
- NAID
  130004626089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590676
[Journal Article] Decreased motility of the lower esophageal sphincter in a rat model of gastroesophageal reflux disease may be mediated by reductions of serotonin and acetylcholine signaling.2011
- Author(s)
  Saegusa Y, Takeda H, Muto S, Oridate N, Nakagawa K, Sadakane C, Nahata M, Harada Y, Iizuka M, Hattori T, Asaka M.
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 34 Pages: 704-711
- NAID
  130000657784
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590676
[Journal Article] 機能性ディスペプシアおよび食欲不振に対する漢方治療2010
- Author(s)
  武田宏司, 武藤修一, 大西俊介, 浅香正博
- Journal Title
  
  日本消化器病学会雑誌
  
  Volume: 107 Pages: 1586-1591
- NAID
  10027493726
- Data Source
  KAKENHI-PROJECT-22590676
[Journal Article] 消化器疾患に対する心身医学的アプローチ高齢者における食欲不振の病態2010
- Author(s)
  武田宏司, 武藤修一
- Journal Title
  
  日本医事新報
  
  Volume: 4500 Pages: 76-80
- NAID
  40017200498
- Data Source
  KAKENHI-PROJECT-22590676
[Journal Article] Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibition.2010
- Author(s)
  Takeda H, Muto S, Hattori T, Sadakane C, Tsuchiya K, Katsurada T, Ohkawara T, Oridate N, Asaka M.
- Journal Title
  
  Endocrinology.
  
  Volume: 151 Pages: 244-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] Deteriorations of gluconeogenesis and locomotor activity due to age-related impairment of sympathetic nervous autophagy activation in mice.2022
- Author(s)
  Mogami S, Nahata M, Sekine H, Fujitsuka N, Ohnishi S, Takeda H
- Organizer
  DDW2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08348
[Presentation] Hepatic sirtuin-1: the key regulator in recovering metabolic disorder through impaired mitochondrial biogenesis in undernourished aged mice.2022
- Author(s)
  Nahata M, Fujitsuka N, Sekine H, Ohbuchi K, Mogami S, Ohnishi S, Takeda H
- Organizer
  DDW2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08348
[Presentation] Dysregulation of liver mitochondrial function and dynamics is associated with vulnerability to undernutrition in aged mice.2019
- Author(s)
  Nahata M., Sekine H., Mogami S., Iizuka S., Fujitsuka N., Takeda H.
- Organizer
  DDW2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09344
[Presentation] Dysfunction of starvation-induced liver autophagy is associated with disruption of adaptive energy metabolism and increased mortality in aged mice on restricted diet.2017
- Author(s)
  Iizuka S, Nahata M, Sekine H, Fujitsuka N, Ohbuchi K, Komokata N, Shimobori C, Hattori T, Takeda H.
- Organizer
  Digestive Disease Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09344
[Presentation] Gender difference in anorexia following stress exposure is dependent on the blocking of ghrelin signal in the NTS.2017
- Author(s)
  Yamada C, Iizuka S, Saegusa Y, Hattori T, Takeda H.
- Organizer
  Digestive Disease Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09344
[Presentation] ストレスによる老齢動物の摂食低下には性差が存在する2015
- Author(s)
  大西俊介、武藤修一、武田宏司
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25460922
[Presentation] セロトニンによるグレリン分泌の調節機構2015
- Author(s)
  武藤修一、大西俊介、武田宏司
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25460922
[Presentation] The hypophagia after psychological stress in aged male mice is mediated by an interaction of activation of estrogen receptor α with serotonin 2C receptor.2015
- Author(s)
  Ohnishi S, Nakagawa K, Okudo N, Yamada C, Saegusa Y, Nahata M, Sadakane C, Hattori T, Sakamoto, N, Takeda H
- Organizer
  Digestive Disease Week 2015
- Place of Presentation
  ワシントンDC（米国）
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460922
[Presentation] Different response to chronic isolation stress between young and aged mice.2015
- Author(s)
  Takeda H, Ohnishi S, Nakagawa K, Okudo N, Yamada C, Saegusa Y, Nahata M, Hattori T, Sakamoto, N
- Organizer
  Digestive Disease Week 2015
- Place of Presentation
  ワシントンDC（米国）
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460922
[Presentation] Gender Difference Influences Food Intake Under an Emotional Stress via 5-HT2CR Activation in Aged Mice.2014
- Author(s)
  Ohnishi S, Muto S, Nakagawa K, Yamada C, Saegusa Y, Nahata M, Sadakane C, Hattori T, Sakamoto, N Takeda H
- Organizer
  Digestive Disease Week 2014
- Place of Presentation
  シカゴ（米国イリノイ州）
- Year and Date
  2014-05-04
- Data Source
  KAKENHI-PROJECT-25460922
[Presentation] The Possibility of Rikkunshito As a Treatment for Anorexia: a Proposal From a Basic Research Perspective.2014
- Author(s)
  Takeda H, Ohnishi S, Muto S, Nakagawa K, Yamada C, Saegusa Y, Nahata M, Sadakane C, Hattori T, Sakamoto, N.
- Organizer
  Digestive Disease Week 2014
- Place of Presentation
  シカゴ（米国イリノイ州）
- Year and Date
  2014-05-06
- Data Source
  KAKENHI-PROJECT-25460922
[Presentation] Rikkunshito, a Traditional Japanese Kampo Medicine, Ameliorates the Decrease in Feeding Behavior in Aged Mice Exposed to Stress via Enhancement of Endogenous Ghrelin Production.2014
- Author(s)
  Muto S, Ohnishi S, Nakagawa K, Yamada C, Saegusa Y, Nahata M, Sadakane C, Hattori T, Sakamoto, N, Takeda H.
- Organizer
  Digestive Disease Week 2014
- Place of Presentation
  シカゴ（米国イリノイ州）
- Year and Date
  2014-05-06
- Data Source
  KAKENHI-PROJECT-25460922
[Presentation] ストレスによる胃機能異常にはグレリンシグナルの異常が関与する（ワークショップ）2014
- Author(s)
  武藤修一, 大西俊介, 武田宏司
- Organizer
  第100回日本消化器病学会総会
- Place of Presentation
  東京国際フォーラム（東京）
- Year and Date
  2014-04-24
- Data Source
  KAKENHI-PROJECT-25460922
[Presentation] 栄養応答シグナルの解明と疾患治療への応用　グレリンシグナルおよびセロトニン2C受容体の意義2014
- Author(s)
  武田宏司, 武藤修一, 大西俊介
- Organizer
  第14回日本抗高齢医学会総会
- Place of Presentation
  大阪国際会議場（大阪）
- Year and Date
  2014-06-06
- Invited
- Data Source
  KAKENHI-PROJECT-25460922
[Presentation] Association of abnormal ghrelin dynamics with delayed gastric emptying in acute restraint-stressed mice.2014
- Author(s)
  Takeda H, Ohnishi S, Muto S, Nakagawa K, Yamada C, Saegusa Y, Nahata M, Sadakane C, Hattori T, Sakamoto, N.
- Organizer
  Digestive Disease Week 2014
- Place of Presentation
  シカゴ（米国イリノイ州）
- Year and Date
  2014-05-05
- Data Source
  KAKENHI-PROJECT-25460922
[Presentation] グレリンシグナルからみた六君子湯の作用メカニズム（漢方セミナー）2014
- Author(s)
  武田宏司
- Organizer
  第56回日本平滑筋学会総会
- Place of Presentation
  新横浜プリンスホテル（横浜）
- Year and Date
  2014-08-08
- Invited
- Data Source
  KAKENHI-PROJECT-25460922
[Presentation] 機能性消化管障害の病態生理と治療戦略2013
- Author(s)
  武田宏司
- Organizer
  第9回日本消化管学会総会(ランチョンセミナー)
- Place of Presentation
  京王プラザホテル(東京)
- Year and Date
  2013-01-26
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] 性差が末梢グレリン分泌に与える影響2012
- Author(s)
  大西俊介、武藤修一、武田宏司
- Organizer
  98回日本消化器病学会(ワークショップ)
- Place of Presentation
  京王プラザホテル(東京)
- Year and Date
  2012-04-19
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] セロトニン、グレリンシグナルと食欲の異常2012
- Author(s)
  武田宏司
- Organizer
  第16回活性アミンに関するワークショップ
- Place of Presentation
  北海道医療大学(北海道札幌市)
- Year and Date
  2012-08-24
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] グレリンシグナルの低下がGERDにおける胃排出低下に関与する2012
- Author(s)
  武田宏司、武藤修一、大西俊介
- Organizer
  JDDW2012(シンポジウム)
- Place of Presentation
  神戸国際会議場他(兵庫県神戸市)
- Year and Date
  2012-10-12
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] 新奇環境ストレスによる食欲不振は血中グレリン低下が原因である2012
- Author(s)
  武藤修一、大西俊介、武田宏司
- Organizer
  第8回日本消化管学会
- Place of Presentation
  仙台国際センター(宮城県仙台市)
- Year and Date
  2012-02-10
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] 癌患者における食欲不振のメカニズム2012
- Author(s)
  武田宏司
- Organizer
  第53回日本心身医学会総会
- Place of Presentation
  かごしま県民交流センター(鹿児島県鹿児島市)
- Year and Date
  2012-05-25
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] The Ghrelin Enhancer Rikkunshito Improves Gastric Dysmotility in Restraint Stress Mice.2012
- Author(s)
  Takeda H, Muto S, Ohnishi S, Nakagawa K, Nahata M, Saegusa Y, Sadakane C, Hattori T, Asaka M.
- Organizer
  DDW2012.
- Place of Presentation
  San Diego Convention Center(米国カリフォルニア州サンディエゴ市)
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] A Study on Gender Differences in Feeding Behavior and Plasma Acyl Ghrelin Levels in Aged Mice Following Exposure to a Novel Environmental Stress.2012
- Author(s)
  Ohnishi S, Takeda H, Muto S, Nakagawa K, Sadakane C, Nahata M, Saegusa Y, Hattori T, Asaka M.
- Organizer
  DDW2012.
- Place of Presentation
  San Diego Convention Center(米国カリフォルニア州サンディエゴ市)
- Year and Date
  2012-05-20
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] Stress-Related Differences in Appetite-Related Genes Between Advanced-Age Male and Female Mice.2012
- Author(s)
  Muto S, Takeda H, Ohnishi S, Nakagawa K, Sadakane C, Saegusa Y, Nahata M, Hattori T, Asaka M.
- Organizer
  DDW2011
- Place of Presentation
  McCormick Place(米国イリノイ州シカゴ市)
- Year and Date
  2012-05-07
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] Potential New Treatment to Alleviate Stress-Induced Anorexia.2012
- Author(s)
  Muto S, Takeda H, Ohnishi S, Nakagawa K, Saegusa Y, Nahata M, Sadakane C, Hattori T, Asaka M.
- Organizer
  DDW2012
- Place of Presentation
  San Diego Convention Center(米国カリフォルニア州サンディエゴ市)
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] 社会的ストレスと消化器症状2012
- Author(s)
  武田宏司、武藤修一、大西俊介
- Organizer
  第78回消化器心身医学研究会(シンポジウム)
- Place of Presentation
  パークハイアット東京(東京)
- Year and Date
  2012-04-20
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] Influence of Gender on Peripheral Ghrelin Secretion-Examination in the Aging Mice-.2011
- Author(s)
  Ohnishi S, Takeda H, Muto S, Nakagawa K, Sadakane C, Saegusa Y, Nahata M, Hattori T, Asaka M.
- Organizer
  DDW2011
- Place of Presentation
  McCormick Place(米国イリノイ州シカゴ市)
- Year and Date
  2011-05-07
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] 六君子湯の食欲改善作用のメカニズム2011
- Author(s)
  武田宏司、武藤修一、大西俊介
- Organizer
  第13回日本神経消化器病学会総会(シンポジウム)
- Place of Presentation
  栃木県総合文化センター(栃木県宇都宮市)
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] 六君子湯は社会的隔離による食欲不振を改善する2011
- Author(s)
  武田宏司,武藤修一,大西俊介
- Organizer
  第97回日本消化器病学会総会(ワークショップ)
- Place of Presentation
  京王プラザホテル(東京)
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] Potential New Treatment to Alleviate Chemotherapy Anorexia.2011
- Author(s)
  Ohnishi S, Takeda H, Muto S, Nakagawa K, Sadakane C, Saegusa Y, Nahata M, Hattori T, Asaka M.
- Organizer
  DDW2011
- Place of Presentation
  McCormick Place(米国イリノイ州シカゴ市)
- Year and Date
  2011-05-10
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] 腹部膨満の病態と大建中湯の役割2011
- Author(s)
  武田宏司、加藤寛士、浅香正博
- Organizer
  第7回日本消化管学会総会
- Place of Presentation
  国立京都国際会館(京都府京都市)
- Year and Date
  2011-02-19
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] Impaired Gastric Emptying in Gastroesophageal Reflux Disease Rat Models is Caused by a Reduced Response to Ghrelin.2011
- Author(s)
  Takeda H, Muto S, Oridate N, Ohnishi S, Nakagawa K, Sadakane C, Saegusa Y, Nahata M, Sadakane C, Hattori T, Asaka M.
- Organizer
  DDW2011
- Place of Presentation
  McCormick Place(米国イリノイ州シカゴ市)
- Year and Date
  2011-05-08
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] 六君子湯は社会的隔離による食欲不振を改善する2011
- Author(s)
  武田宏司, 武藤修一, 大西俊介
- Organizer
  第97回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] Novelty Stress-Induced Anorexia is Due to the Decrease in the Plasma Ghrelin Level via 5-HT1b/2C-Melanocortin4 System Activation.2011
- Author(s)
  Muto S, Takeda H, Ohnishi S, Nakagawa K, Sadakane C, Saegusa Y, Nahata M, Hattori T, Asaka M.
- Organizer
  DDW2011
- Place of Presentation
  McCormick Place(米国イリノイ州シカゴ市)
- Year and Date
  2011-05-10
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] Ghrelin Alleviates Social Isolation-Associated Anorexia in Mice.2010
- Author(s)
  Saegusa Y, Takeda H, Sadakane C, Hattori T, Katsurada T, Muto S, Asaka M.
- Organizer
  DDW2010.
- Place of Presentation
  The Ernest N. Morial Convention Center(米国ルイジアナ州ニューオリンズ市)
- Year and Date
  2010-05-03
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] 消化器疾患と六君子湯・大建中湯2010
- Author(s)
  武田宏司
- Organizer
  第12回日本神経消化器病学会(市民講座)
- Place of Presentation
  鹿児島大学稲盛会館(鹿児島県鹿児島市)
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] 食欲不振に対する六君子湯の効果2010
- Author(s)
  武田宏司、武藤修一、大西俊介、浅香正博
- Organizer
  第12回日本神経消化器病学会総会(シンポジウム)
- Place of Presentation
  城山観光ホテル(鹿児島県鹿児島市)
- Year and Date
  2010-10-01
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] 消化器癌化学療法にともなう食欲不振のメカニズムとその対策2010
- Author(s)
  武藤修一、武田宏司、浅香正博
- Organizer
  第96回日本消化器病学会総会シンポジウム
- Place of Presentation
  新潟市朱鷺メッセ(新潟県新潟市)
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] 消化器癌化学療法にともなう食欲不振のメカニズム2010
- Author(s)
  武藤修一、武田宏司、浅香正博
- Organizer
  第96回日本消化器病学会総会
- Place of Presentation
  新潟
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] 加齢による食欲不振のメカニズムとその対策2010
- Author(s)
  武藤修一、平山剛、武田宏司
- Organizer
  JDDW2010(シンポジウム)
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] Social Isolation After Anorexia is Mediated by Abnormalities in Serotonin 2C Receptor Reactivity.2010
- Author(s)
  Sadakane C, Takeda H, Saegusa Y, Hattori T, Nakagawa K, Muto S, Asaka M.
- Organizer
  DDW2010.
- Place of Presentation
  The Ernest N. Morial Convention Center(米国ルイジアナ州ニューオリンズ市)
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] 食欲の科学2010
- Author(s)
  武田宏司
- Organizer
  第96回日本消化器病学会総会(ランチョンセミナー)
- Place of Presentation
  新潟市朱鷺メッセ(新潟県新潟市)
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] 急性拘束ストレスによる胃排出遅延にはグレリンシグナル伝達障害が関与する
- Author(s)
  武田宏司
- Organizer
  第55回日本平滑筋学会総会
- Place of Presentation
  旭川市大雪クリスタルホール（北海道旭川市）
- Invited
- Data Source
  KAKENHI-PROJECT-25460922
[Presentation] 社会的ストレスと消化器症状
- Author(s)
  武田宏司
- Organizer
  第53回日本心身医学会総会
- Place of Presentation
  かごしま県民交流センター（鹿児島県鹿児島市）
- Invited
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] Serotonin 2C Receptor Antagonism Improves Stress-Induced Anorexia in Aged Mice.
- Author(s)
  2) Muto S, Ohnishi S, Nakagawa K, Sadakane C, Saegusa Y, Nahata M, Yamada C, Hattori T, Asaka M, Takeda H.
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  オーランド（米国フロリダ州）
- Data Source
  KAKENHI-PROJECT-25460922
[Presentation] Involvement of Ghrelin Signaling Dysfunction in Acute Restraint Stress-Induced Delayed Gastric Emptying.
- Author(s)
  3) Ohnishi S, Muto S, Nakagawa K, Sadakane C, Saegusa Y, Nahata M, Yamada C, Hattori T, Asaka M, Sakamoto, N Takeda H.
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  オーランド（米国フロリダ州）
- Data Source
  KAKENHI-PROJECT-25460922
[Presentation] ctivation of Corticotropin-Releasing Factor 2 and Melanocortin-4 Receptors Mediates the Persistent Loss of Appetite Induced by Stress Loading in Advanced Age Mice.
- Author(s)
  Takeda H, Muto S, Ohnishi S, Nakagawa K, Sadakane C, Saegusa Y, Nahata M, Yamada C, Hattori T, Asaka M. A
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  オーランド（米国フロリダ州）
- Data Source
  KAKENHI-PROJECT-25460922
[Presentation] グレリンシグナルの低下がGERDにおける胃排出低下に関与する
- Author(s)
  武田宏司、武藤修一、大西俊介
- Organizer
  JDDW2012
- Place of Presentation
  神戸国際会議場他（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] セロトニン、グレリンシグナルと食欲の異常
- Author(s)
  武田宏司
- Organizer
  第16回活性アミンに関するワークショップ
- Place of Presentation
  北海道医療大学（北海道札幌市）
- Invited
- Data Source
  KAKENHI-PROJECT-22590676
[Presentation] ストレスによる老齢動物の摂食低下には5-HT2C受容体の機能亢進が関与する
- Author(s)
  大西俊介、武藤修一、武田宏司
- Organizer
  JDDW2013 （シンポジウム）
- Place of Presentation
  グランドプリンスホテル新高輪他（東京都）
- Data Source
  KAKENHI-PROJECT-25460922

1. OHKAWARA Tatsuya (00374257)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. OHNISHI Shunsuke (10443475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. NISHIHIRA Jun (30189302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. INOUE Nobuo (20091415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KASHIWAZAKI Haruhiko (10344516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MORIYA Shingo (70344520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 佐久間英輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 和田郁雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 早川峰司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 大久保直登

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 夏井坂光輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takeda Hiroshi 武田 宏司

TAKEDA Hiroshi 武田 宏司

Research Projects

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Co-Researchers

Do sirtuins contribute to the anti-inflammatory effects of ghrelin?Principal Investigator

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Does coffee polyphenol inhibit the level of MIF and the development of inflammatory carcinogenesis.

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Role of novel ghrelin receptor binding protein PLA2G16 in gastrointestinal cancer cellsPrincipal Investigator

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Rikkunshito increased hypothalamic SIRT1 activityPrincipal Investigator

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Role of Macrophage migration inhibitory factor in non-alcoholic steatohepatitis

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The mechanism by which rikkunshito increases acylated ghrelinPrincipal Investigator

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Immunologcal effect of professional oral health care on the elderly requiring long-term care

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Helicobacter pylori and its association with gastric cancerPrincipal Investigator

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[Journal Article] Decline in Liver Mitochondria Metabolic Function Is Restored by Hochuekkito Through Sirtuin 1 in Aged Mice With Malnutrition.2022

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[Journal Article] Role of Mitochondrial Dysfunction in the Pathogenesis of Cisplatin-Induced Myotube Atrophy2022

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[Journal Article] Protective effect of ISO-1 with inhibition of RIPK3 up-regulation and neutrophilic accumulation on acetaminophen-induced liver injury in mice2021

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[Journal Article] Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines2019

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[Journal Article] The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds.2018

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Takeda Hiroshi 武田宏司

TAKEDA Hiroshi 武田宏司