SHIRAI YASUHITO 白井康仁

… Alternative Names

Ysuhito Shirai 白井康仁

Shirai Yasuhito 白井康仁

SHIRAI Yasuhito 白井康仁

白井康仁シライヤスヒト

Less

Researcher Number	60263399
Other IDs
External Links
Affiliation (Current)	2025: 神戸大学, 農学研究科, 教授
Affiliation (based on the past Project Information) *help	2022: 神戸大学, 農学研究科, 教授 2016 – 2020: 神戸大学, 農学研究科, 教授 2015: 神戸大学, (連合)農学研究科(研究院), 教授 2011: 神戸大学, バイオシグナル研究センター, 准教授 2011: 神戸大学, 大学院・農学研究科, 教授 … More 2010 – 2011: 神戸大学, 農学研究科, 教授 2008 – 2009: 神戸大学, 自然科学系先端融合研究環バイオシグナル研究センター, 准教授 2007 – 2008: 神戸大学, バイオシグナル研究センター, 准教授 2002 – 2006: Kobe University, Biosignal Research Center, Assistant Professor, バイオシグナル研究センター, 助教授 2001: 神戸大学, バイオシグナル研究センター, 助手 2000: 神戸大, 助手 1997 – 1999: 神戸大学, バイオシグナル研究センター, 助手 1995: 神戸大学, 自然科学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Functional biochemistry / Functional biochemistry / Basic Section 38050:Food sciences-related / Biological Sciences / 蚕糸・昆虫利用学 Except Principal Investigator General pharmacology / Biological Sciences / Applied health science / Eating habits / Structural biochemistry / General medical chemistry / General pharmacology
Keywords	Principal Investigator ジアシルグリセロールキナーゼ / プロテインキナーゼC / NMR / フォスファチジン酸 / ジアシルグリセロール / 脂質キナーゼ / 腎症 / 糖尿病 / 脂質シグナル / 脂質 … More / 可視化 / セラミド / C1ドメイン / 脂肪酸 / PKC / エピガロカテキンがレート / 糖尿病合併症 / DGキナーゼ / ラフト / パルミトイル化 / カテキン / ビタミンE / ホスファチジン酸 / 癌 / 細胞周期 / チロシンリン酸化 / 細胞内局在変化 / 結合タンパク質 / Ceramide / Lipid messenger / Fatty acid / C1 domain / Diacylglycerol kinase / Protein kinase C / DGK / KOマウス / 記憶 / LTP / スパイン / 神経 / 細胞情報伝達機構 / 蛋白質 / シグナル伝達 / 共焦点顕微鏡 / ホルボールエステル / アラキドン酸 / 脂質性シグナル / ターゲティング / ターゲッティング / ホスホリパーゼA2 / 低分子量G蛋白質 / 蛋白質リン酸化 / ペプチド分泌 / カイコ前胸腺刺激ホルモン / 神経ペプチド … More Except Principal Investigator プロテインキナーゼC / GFP / サブタイプ / トランスロケーション / 遺伝子操作動物 / イメージング / 神経可塑性 / カルシウム / 変異体 / ジアシルグリセロール / ジアシルグリセロールキナーゼ / protein kinase C / 脂質 / 脊髄小脳変性症 / 遺伝子変異 / 神経変性 / ファゴサイトーシス / ターゲティング / ライブイメージング / トランスジェニックマウス / ホルボールエステル / 脱リン酸化 / リン酸化 / トランスポーター / セロトニン / 膵β細胞量 / インスリン / 新生 / β 細胞 / 増殖 / β細胞 / 糖尿病 / Th1/Th2バランス / 樹状細胞 / 小腸上皮細胞 / 免疫学 / 栄養学 / 食品 / 食物繊維 / 制御性T細胞 / グルカン / 腫瘍壊死因子受容体1 / Dectin-1 / 腫瘍壊死因子受容体 / 炎症性腸疾患 / 抗炎症作用 / レンチナン / sortase / キナーゼ / マルチドメインタンパク質 / NMR / プロテインライゲーション / ischemia / Spinocerebellar ataxia / NADPH oxidase / phagocytosis / diacylglycerol kinase / lipid / live imaging / カスケード / 脂質メッセンジャー / 凝集体形成 / 核移行 / 細胞周期 / 虚血 / 小脳脊髄変性症 / NADPHオキシダーゼ / ドン食作用 / transgenic mice / apoptosis / green fluorescent protein / subtype / targeting / 可視化 / 細胞死 / electron microscopy / synapse / depression / phosphorylation / interferon / transporter / serotonin / COS-7細胞 / 電子顕微鏡 / シナプス / うつ病 / インターフェロン / アミロイド / 細胞内情報伝達 / 創薬 / モデル動物 / 神経変性疾患 / プロテインキナーゼ / パーキンソン病 / 精髄小脳変性症 / 構造解析 / 膜蛋白 / 抗体療法 / 抗体 / 膜タンパク / DNA vaccination / 活性酵素 / マクロファージ / Rac / 活性酸素 / 長期抑圧 / シルグリセロールキナーゼ / 発癌 / DGキナーゼ / セラミド / green fluourescent protein / ジアルシルグリセロールキナーゼ / Tet制御システム / プイロテインキナーゼC / 小脳プルキンエ細胞 / 蛋白質リン酸化 / ATP受容体 / 脂肪酸 / 長期増強 / 培養細胞 / コンフォーカル顕微鏡 / クロライド / ナトリウム Less

Mechanism of DG kinase-mediated improvement of diabetic nephropathy by food ingredients and its applicationPrincipal Investigator
- Principal Investigator
  
  Ysuhito Shirai
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Kobe University
Intracellular lipid signaling analysis for the development of novel diabetes therapeutic agents targeting neogenesis and proliferation of pancreatic beta-cells
- Principal Investigator
  
  Ishikawa Tomohisa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  University of Shizuoka
Comprehensive investigation of molecular mechansim of intracellular localization of DG kinase as an example of general enzmesPrincipal Investigator
- Principal Investigator
  
  Shirai Yasuhito
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
Dynamical study of multi-domain kinases reconstructed by domain ligation
- Principal Investigator
  
  Mishima Masaki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo Metropolitan University
Functional foods development to contribute to the healthy reinforcement using the immate immunity through receptor recognizing polysaccharide on small intestine epithelium
- Principal Investigator
  
  Mizuno Masashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits
- Research Institution
  Kobe University
Production and analysis of model animals for neurodegenerative diseases caused by dysfunction of PKC and their use for drug design
- Principal Investigator
  
  SAITO Naoaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kobe University
Analysis of DG kinase functions related to PKC and its application for future drug.Principal Investigator
- Principal Investigator
  
  SHIRAI Yasuhito
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
Mechanism and treatment for the disease caused by the impairment of PKC signaling
- Principal Investigator
  
  SAITO Naoaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kobe University
核内脂質シグナル及び核移行蛋白質の可視化システムを用いた細胞周期制御機構の解明Principal Investigator
- Principal Investigator
  
  白井康仁
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Molecular mechanism of cellular response induced by dynamic metabolism of membrane phospholipid
- Principal Investigator
  
  SAITO Naoaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kobe University
小脳長期抑圧現象におけるプロテインキナーゼCおよびDGキナーゼの時空間解析
- Principal Investigator
  
  齋藤尚亮
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
活性酸素産生機構における脂質シグナルのダイナミックイメージング解析
- Principal Investigator
  
  齋藤尚亮
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
DNA Vaccinationによる膜機能蛋白に対する抗体作成
- Principal Investigator
  
  TANIGUCHI Taizo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Kobe University
PKCターゲティングのFRETによる抗癌剤のハイスループットスクリーニングの開発
- Principal Investigator
  
  齋藤尚亮
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Kobe University
Analysis of higher structure of fatty aid -responsible domains in PKC and DGKPrincipal Investigator
- Principal Investigator
  
  SHIRAI Yasuhito
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
CキナーゼとDGキナーゼの神経情報伝達におけるクロストーク機構のイメージング解析
- Principal Investigator
  
  齋藤尚亮
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
神経可塑性制御に対するPKCの役割-トランスジェニックマウスを用いた研究-
- Principal Investigator
  
  酒井規雄
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
  Kobe University
CキナーゼとDGキナーゼの神経情報伝達におけるクロストーク機構の解析
- Principal Investigator
  
  齋藤尚亮
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
CキナーゼとDGキナーゼの脂質性シグナルによる標的認識機構の解明Principal Investigator
- Principal Investigator
  
  白井康仁
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
Spatio-temporal signaling mechanism of protein kinase C
- Principal Investigator
  
  SAITO Naoaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  KOBE UNIVERSITY
可視化システムを用いたプロテインキナーゼCのターゲティング機構の解析Principal Investigator
- Principal Investigator
  
  白井康仁
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
GFP標識プロテインキナーゼC遺伝子改変マウスの作製とその神経可塑性研究への応用
- Principal Investigator
  
  斎藤尚亮
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kobe University
プロテインキナーゼCサブタイプの活性化とターゲッティング機構の関連に関する研究
- Principal Investigator
  
  斎藤尚亮
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kobe University
Na^+/Cl^-依存性トランスポーターの分子間相互作用と機能協関する蛋白質の検索
- Principal Investigator
  
  SAITO Naoaki
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
蛍光標識プロテインキナーゼCの遺伝子改変マウスの作製とその神経可塑性研究への応用
- Principal Investigator
  
  斎藤尚亮
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
Research for modulation of expression of serotonin transporter and its involvement in mental disorder
- Principal Investigator
  
  SAITO Naoaki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  KOBE UNIVERSITY
カイコ前胸腺刺激ホルモン分泌におけるリン酸化タンパク質の解析Principal Investigator
- Principal Investigator
  
  白井康仁
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  蚕糸・昆虫利用学
- Research Institution
  Kobe University

[Journal Article] Screening of subtype-specific activators and inhibitors for diacylglycerol kinase2019
- Author(s)
  Hayashi Daiki、Tsumagari Ryosuke、Liu Ke、Ueda Shuji、Yamanoue Minoru、Sakane Fumio、Shirai Yasuhito
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 印刷中 Issue: 6 Pages: 517-522
- DOI
  10.1093/jb/mvz008
- NAID
  40021920841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03650, KAKENHI-PROJECT-17H02175
[Journal Article] Amelioration of diabetic nephropathy by oral administration of d-α-tocopherol and its mechanisms2018
- Author(s)
  Hayashi Daiki、Ueda Shuji、Yamanoue Minoru、Ashida Hitoshi、Shirai Yasuhito
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 82 Issue: 1 Pages: 65-73
- DOI
  10.1080/09168451.2017.1411184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02175, KAKENHI-PROJECT-16J02115, KAKENHI-PROJECT-15K07002
[Journal Article] Epigallocatechin gallate induces GLUT4 translocation in skeletal muscle through both PI3K- and AMPK-dependent pathways2018
- Author(s)
  Ueda-Wakagi Manabu、Hayashibara Kaori、Nagano Tomoya、Ikeda Masaki、Yuan Sihao、Ueda Shuji、Shirai Yasuhito、Yoshida Ken-ichi、Ashida Hitoshi
- Journal Title
  
  Food & Function
  
  Volume: 9 Issue: 8 Pages: 4223-4233
- DOI
  10.1039/c8fo00807h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H00818, KAKENHI-PROJECT-17H02175
[Journal Article] Diacylglycerol kinase α‐selective inhibitors induce apoptosis and reduce viability of melanoma and several other cancer cell lines2018
- Author(s)
  Yamaki Atsumi、Akiyama Rino、Murakami Chiaki、Takao Saki、Murakami Yuki、Mizuno Satoru、Takahashi Daisuke、Kado Sayaka、Taketomi Akinobu、Shirai Yasuhito、Goto Kaoru、Sakane Fumio
- Journal Title
  
  Journal of Cellular Biochemistry
  
  Volume: 120 Issue: 6 Pages: 10043-10056
- DOI
  10.1002/jcb.28288
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02175, KAKENHI-PROJECT-17H03650, KAKENHI-PROJECT-18J20003, KAKENHI-PROJECT-17K15444, KAKENHI-PROJECT-17K11581
[Journal Article] DgMab-6: Antihuman DGKgamma Monoclonal Antibody for Immunocytochemistry.2018
- Author(s)
  Nakano T, Ogasawara S, Tanaka T, Hozumi Y, Yamaki A, Sakane F, Shirai Y, Nakamura T, Yanaka M, Yamada S, Kaneko MK, Kato Y, Goto K.
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: 37 Issue: 5 Pages: 229-232
- DOI
  10.1089/mab.2018.0026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08507, KAKENHI-PROJECT-17H02175, KAKENHI-PROJECT-17H03650
[Journal Article] Comparative metabolomics of Japanese Black cattle beef and other meats using gas chromatography?mass spectrometry2018
- Author(s)
  Ueda Shuji、Iwamoto Eiji、Kato Yoshiki、Shinohara Masakazu、Shirai Yasuhito、Yamanoue Minoru
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 83 Issue: 1 Pages: 137-147
- DOI
  10.1080/09168451.2018.1528139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02175, KAKENHI-PROJECT-16K08007, KAKENHI-PROJECT-17K01847
[Journal Article] Diacylglycerol kinase alpha is involved in the vitamin E-induced amelioration of diabetic nephropathy in mice2017
- Author(s)
  Daiki Hayashi1 Keiko Yagi, Chihong Song, Shuji Ueda, Minoru Yamanoue, Matthew Topham, Toshinobu Suzaki, Naoaki Saito, Noriaki Emoto and Yasuhito Shirai
- Journal Title
  
  Scientific Repots
  
  Volume: 7 Issue: 1 Pages: 2597-2597
- DOI
  10.1038/s41598-017-02354-3
- NAID
  120006348186
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K00613, KAKENHI-PROJECT-17H02175, KAKENHI-PROJECT-16J02115, KAKENHI-PROJECT-15K07002
[Journal Article] Effects of vitamin E and its derivatives on diabetic nephropathy in Rats and identification of diacylglycerol kinase subtype involved in the improvement of diabetic nephropathy2017
- Author(s)
  Kakehi T, Yagi K, Saito N, Shirai Y
- Journal Title
  
  Functional Foods in Health and Disease
  
  Volume: 7 Pages: 816-832
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07002
[Journal Article] Effects of vitamin E and its derivatives on diabetic nephropathy in Rats and identification of diacylglycerol kinase subtype involved in the improvement of diabetic nephropathy2017
- Author(s)
  Tomoko Kakehi、Keiko Yagi、Naoaki Saito、Yasuhito Shirai
- Journal Title
  
  Functional Foods In Health And Disease
  
  Volume: 7 Pages: 816-832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02175
[Journal Article] A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response2015
- Author(s)
  1)Lui K, Kunii N, Sakuma M, Yamaki A, Mizuno S, Sato M, Sakai H, Kado S, Kumagai K, Kojima H, Okabe T, Nagano T, Shirai Y. and Sakane F
- Journal Title
  
  J lipid res
  
  Volume: ５７ Issue: 3 Pages: 368-379
- DOI
  10.1194/jlr.m062794
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07002, KAKENHI-PROJECT-15K14470, KAKENHI-PROJECT-15K18859, KAKENHI-PROJECT-26291017
[Journal Article] MARCKS dephosphorylation is involved in bradykinin-induced neurite outgrowth in neuroblastoma SH-SY5Y cells2012
- Author(s)
  Tanabe A, Shiraishi M, Negishi M, Saito N, Tanabe M, and Sasaki Y.
- Journal Title
  
  J Cell Physiol
  
  Volume: 227(2) Pages: 618-629
- Data Source
  KAKENHI-PROJECT-21390070
[Journal Article] c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol kinase・by phosphorylation at Tyr2182012
- Author(s)
  Matsubara, M., Ikeda, M., Kiso, Y., Sakuma, M., Sakane, F., Merida, I, Saito, N. and Shirai, Y.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Pages: 5507-5517
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] Regulation of diacylglycerol kinase by phosphorylation2012
- Author(s)
  Shirai, Y., Ikeda, M., Saito, N.
- Journal Title
  
  Adv. biological. Reg.
  
  Volume: 52 Pages: 239-247
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol kinaseαby phosphorylation at Tyr2182012
- Author(s)
  Matsubara, T., Ikeda, M., Kiso, Y., Sakuma, M., Yoshino, K-I., Sakane, F., Merida, I., Saito, N. and Shirai, Y.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287 Pages: 5507-5517
- Data Source
  KAKENHI-PROJECT-21390070
[Journal Article] MARCKS dephosphorylation is involved in bradykinin-induced neurite outgrowth in neuroblastoma SH-SY5Y cells2012
- Author(s)
  Tanabe A, Shiraishi M, Negishi M, Saito N, Tanabe M, Sasaki Y
- Journal Title
  
  J Cell Physiol
  
  Volume: 227 Pages: 618-629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390070
[Journal Article] c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol kinase α by phosphorylation at Tyr2182012
- Author(s)
  Matsubara, T., Ikeda, M., Kiso, Y., Sakuma, M., Yoshino, K-I., Sakane, F., Merida, I., Saito, N., Shirai, Y.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 287 Pages: 5507-5517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390070
[Journal Article] Streptococcus mutans diacylglycerol kinase homologue : a potential target for anti-caries chemotherapy2011
- Author(s)
  Shibata, Y., Kawada-Matsuo, M., Shirai, Y, Saito, N., Li.D., Yamashita, Y.
- Journal Title
  
  J.Med.Microbiol.
  
  Volume: 60 Pages: 625-630
- NAID
  120004951599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390070
[Journal Article] A critical role of conventional protein kinase C in morphological changes of rodent mast cells.2011
- Author(s)
  Yanase Y., Hide I, Mihara S., Shirai Y., Saito N., Nakata Y., Hide M., Sakai N.
- Journal Title
  
  Immunol.Cell.Biol
  
  Volume: 83 Pages: 149-159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] Direct biding of RalA to PKCη and its crucial role in morphological change during keratinocytes differentiation2011
- Author(s)
  Shirai, Y., Morioka, S., Sakuma, M., Yoshino, K., Otsuji, C., Sakai, N., Kashiwagi, K., Chida, K., Shirawaka, R., Horiuchi, H., Nishigori, C., Ueyama, T., Saito, N.
- Journal Title
  
  Mol.Biol.Cell
  
  Volume: 22 Pages: 1340-1352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] Regulation of diacylglycerol kinase by phosphorylation2011
- Author(s)
  Shirai, Y., Ikeda, M., Saito, N.
- Journal Title
  
  Adv.Enz.Reg.
  
  Volume: (Web) Issue: 1 Pages: 239-247
- DOI
  10.1016/j.advenzreg.2011.09.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol kinase α by phosphorylation at Tyr2182011
- Author(s)
  Matsubara, M., Ikeda, M., Kiso, Y., Sakuma, M., Sakane, F., Merida, I, Saito, N., Shirai, Y.
- Journal Title
  
  J.Biol.Chem
  
  Volume: 287 Issue: 8 Pages: 5507-5517
- DOI
  10.1074/jbc.m111.296897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570139, KAKENHI-PROJECT-23659137, KAKENHI-PUBLICLY-23113511
[Journal Article] Streptococcus mutans diacylglycerol kinase homologue : a potential target for anti-caries chemotherapy2011
- Author(s)
  Shibata, Y., Kawada-Matsuo, M., Shirai, Y., Saito, N., Li. D., and Yamashita, Y.
- Journal Title
  
  J. Med. Microbiol
  
  Volume: 60 Pages: 625-630
- NAID
  120004951599
- Data Source
  KAKENHI-PROJECT-21390070
[Journal Article] Direct biding of RalA to PKC・and its crucial role in morphological change during keratinocytes differentiation2011
- Author(s)
  Shirai, Y., Morioka, S., Sakuma, M., Yoshino, K., Otsuji, C., Sakai, N., Kashiwagi, K., Chida, K., Shirawaka, R., Horiuchi, H., Nishigori, C., Ueyama, T. and Saito, N
- Journal Title
  
  Mol. Biol. Cell
  
  Volume: 22 Pages: 1340-1352
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocytes differentiation2011
- Author(s)
  Shirai, Y., Morioka, S., Sakuma, M., Yoshino, K., Otsuji, C., Sakai, N., Kashiwagi, K., Chida, K., Shirakawa, R., Horiuchi, H., Nishigori, C., Ueyama, T., Saito, N.
- Journal Title
  
  Mol.Biol.Cell
  
  Volume: 22 Pages: 1340-1352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390070
[Journal Article] Direct binding of RalA to PKCh and its crucial role in morphological change during keratinocytes differentiation2011
- Author(s)
  Shirai, Y., Morioka, S., Sakuma, M., Yoshino, K., Otsuji, C., Sakai, N., Kashiwagi, K., Chida, K., Shirakawa, R., Horiuchi, H., Nishigori, C., Ueyama, T., Saito, N.
- Journal Title
  
  Mol. Biol. Cell
  
  Volume: 22 Pages: 1340-1352
- Data Source
  KAKENHI-PROJECT-21390070
[Journal Article] Streptococcus mutans diacylglycerol kinase homologue : a potential target for anti-caries chemotherapy2011
- Author(s)
  Shibata, Y., Kawada-matsuo, M., Shirai, Y., Saito, N., Li, D., Yamashita, Y.
- Journal Title
  
  J.Medical Microbiol.
  
  Volume: 60 Pages: 625-630
- NAID
  120004951599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] A critical role of conventional protein kinase C in morphological changes of rodent mast cells2010
- Author(s)
  Yanase Y., Hide, I., Mihara, S., Shirai, Y., Saito, N., Nakata, Y., Hide, M., and Sakai, N.
- Journal Title
  
  Immunol. Cell. Biol
  
  Volume: 89(1) Pages: 149-59
- Data Source
  KAKENHI-PROJECT-21390070
[Journal Article] Suppression mechanisms of flavaonoids on aryl hydrocarbon receptor-mediated signal transduction.2010
- Author(s)
  Mukai R, Shirai Y., Saito N., Fukuda I., Nishiumi S., Yoshida K., Ashida H.
- Journal Title
  
  Arch.Biochem.Biophys
  
  Volume: 501 Pages: 134-141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities2010
- Author(s)
  Kakefuda K., Oyagi A., Ishisaka, M., Tsumura, K., Shimazawa M., Yokota, K. Shirai Y., Horie K., Saito N.,Takeda J., Hara H.
- Journal Title
  
  PLoS ONE
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] Diacylglycerol kinase・・knockout mice exhibit lithium-sensitive behavioral abnormalities2010
- Author(s)
  Kakefuda K., Oyagi A., Ishisaka, M., Tsumura, K., Shimazawa M., Yokota, K., Shirai Y., Horie K., Saito N., Takeda J. and Hara H.
- Journal Title
  
  PLoS ONE
  
  Volume: 5
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] Essential role of diacylglycerol kinase beta(DGKb) in neurite spine formation, contributing to cognitive function including spatial and long-term memory2010
- Author(s)
  Shirai, Y., Kozuki, T., Kakefuda, K., Moriguchi, S., Oyagi, A., Horie, K., Shimazawa, M., Fukunaga, K., Takeda, J., Saito, N., Hara, H.
- Journal Title
  
  PLoS One
  
  Volume: 5(7)
- Data Source
  KAKENHI-PROJECT-21390070
[Journal Article] Diacylglycerol kinaseβknockout mice exhibit lithium-sensitive behavioral abnormalities2010
- Author(s)
  Kakefuda K., Oyagi A., Ishisaka M., Tsuruma K., Shimazawa M., Yokota K., Shirai Y., Horie K., Saito N., Takeda J. and Hara H.
- Journal Title
  
  PLoS One
  
  Volume: 5(10)
- Data Source
  KAKENHI-PROJECT-21390070
[Journal Article] Supression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction2010
- Author(s)
  Mukai, R., Shirai, Y., Saito, N., Fukuda, I., Nishiumi, S., Yoshida, K., Ashida, H.
- Journal Title
  
  Arch. Biochem. Biophys
  
  Volume: 501 Pages: 134-141
- Data Source
  KAKENHI-PROJECT-21390070
[Journal Article] DGKβ in neurite spine formation, contributing to cognitive function.2010
- Author(s)
  Shirai Y., Kouzuki T., Kakefuda K., Moriguchi S., Oyagi A., Horie K., Morita S., Shimazawa M., Fukunaga K., Takeda J., Saito N., Hara H.
- Journal Title
  
  PLoS ONE
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] Essential role of diacylglycerol kinase beta (DGKb) in neurite spine formation, contributing to cognitive function including spatial and long-term memory.2010
- Author(s)
  Shirai, Y., et al.
- Journal Title
  
  PLoS One
  
  Volume: 5(7)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390070
[Journal Article] Essential role of neuron-enriched diacylglycerol kinase(DGK), DGK・in neurite spine formation, contributing to cognitive function2010
- Author(s)
  Shirai Y., Kouzuki T., Kakefuda K., Moriguchi S., Oyagi A., Horie K., Morita S., Shimazawa M., Fukunaga K., Takeda J., Saito N. and Hara H
- Journal Title
  
  PLoS ONE
  
  Volume: 5
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] An essential role of the aPKC-aurora A-NDEL1 pathway on neurite elongation by modulation of microtubule dynamics2009
- Author(s)
  Mori D., Yamada M., Mimori-Kiyosue Y., Shirai Y., Suzuki A., Ohno S., Saya H., Wynshaw-Boris A. and Hirotsune H.
- Journal Title
  
  Nature Cell Biol
  
  Volume: 11 Pages: 1057-1068
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] Inflammatory cytokine TNF-alpha enhances NGF production in human keratinocytes, HaCaT cells2009
- Author(s)
  Takaoka K., Shirai Y. and Saito N.
- Journal Title
  
  J. Pharmacol. Sci.
  
  Volume: 111 Pages: 381-391
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] Kinase activity of the dgk gene product is involved in the virulence of Streptococcus mutants.2009
- Author(s)
  Shibata Y., van der Ploeg JR., Kozuki T., Shirai Y, Saito N, Kawada-Matsuo M, Takeshita T, Yamashita Y
- Journal Title
  
  Microbiology 155
  
  Pages: 557-565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] Inflammatory cytokine TNF-alpha enhances NGF production in human keratinocytes, HaCaT cells2009
- Author(s)
  Takaoka K., Shirai Y., Saito N
- Journal Title
  
  J.Pharmacol.Sci. 111
  
  Pages: 381-391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] An essential role of the aPKC-aurora A-NDEL1 pathway on neurite elongation by modulation of microtubule dynamics.2009
- Author(s)
  Mori D., Yamada M., Mimori-Kiyosue Y., Shirai Y., Suzuki A., Ohno S., Saya H., Wynshaw-Boris A., Hirotsune H
- Journal Title
  
  Nature Cell Biol. 11
  
  Pages: 1057-1068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570139
[Journal Article] Kinase activity of the dgk gene product is involved 1 in the virulence of Streptococcus mutans Microbiology2009
- Author(s)
  Shibata, Y., van der Ploeg, JR., Kozuki, T., Shirai, Y., Saito, N., Kawada, M., Takeshita, T., and Yamashita, Y.
- Journal Title
  
  155
  
  Pages: 557-565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390064
[Journal Article] Ca^<2+> oscillation induced by P2Y2 receptor activation and its regulation by a neuron-specific subtype of PKC (βPKC)2008
- Author(s)
  Ashida, N., Ueyama, T., Rikitake, K., Shirai, Y. Eto, M., Kondoh, T., Kohmura, E., and Saito, N.
- Journal Title
  
  Neurosci. Lett 446
  
  Pages: 123-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390064
[Journal Article] Reactive oxygen species derived from NOX1/NADPH oxidase enhance inflammatory pain2008
- Author(s)
  Ibi, M., Matsuno, K., Shiba, D., Katsuyama, M., Iwata, K., Kakehi, T., Nakagawa, T., Sango, K., Shirai, Y., Yokoyama, T., Kaneko, S., Saito N.,and Yabe-Nishimura, C.
- Journal Title
  
  J. Neurosci 28
  
  Pages: 9486-9494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390064
[Journal Article] Sequential Binding of Cytosolic Phox Complex to Phagosomes through Regulated Adaptor Proteins : Evaluation Using the Novel Monomeric Kusabira-Green System and Live Imaging of Phagocytosis2008
- Author(s)
  Ueyama, T., Kusakabe, T., Karasawa, S., Kawasaki, T., Shimizu, A., Son J-H, Shirai, Y., Leto, TL., Miyawaki, A., and Saito N.
- Journal Title
  
  J. Immunol 181
  
  Pages: 629-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390064
[Journal Article] Regulation of Clathrin Dependent Endocytosis by Diacylglycerol kinaseδ2008
- Author(s)
  Kawasaki, T., Kobayashi, T., Ueyama, T., Shirai, Y. and Saito, N.
- Journal Title
  
  -Importance of Kinase Activity and Binding to AP2α-Biochem. J 409
  
  Pages: 471-479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390064
[Journal Article] Lck-dependent tyrosine phosphorylation of DGK alpha regulates its membrane association in T cells2008
- Author(s)
  Merino, E. Avila-Flores, A., Shirai, Y., Moraga, I., Saito, N. and Merida, I.
- Journal Title
  
  J. Immunol 180
  
  Pages: 5805-5815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390064
[Journal Article] Minireview : Protein kinase Cε-function in neurons2008
- Author(s)
  Shirai, Y., Adachi, N. and Saito, N.
- Journal Title
  
  FEBS J 275
  
  Pages: 3988-3994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390064
[Journal Article] Minireview : Protein kinase Ce-function in neurons.2008
- Author(s)
  Shirai, Y., 他
- Journal Title
  
  FEBS J. 275
  
  Pages: 3988-3994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390064
[Journal Article] Enzymological analysis of mutant protein kinase Cγ causing spinocerebellar ataxia type 14 and its dysfunction in Ca^<2+> homeostasis2008
- Author(s)
  Adachi, N., Kobayashi, T., Takahashi, H., Kawasaki, T., Shirai, Y., Ueyama, T., Matsuda, T., Seki, T., Sakai, N. and Saito N.
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 19854-19863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390064
[Journal Article] A novel PIP2 binding of εPKC and its contribution to the neurite induction ability2007
- Author(s)
  Shirai, Y., Murakami, T., Kuramasu, M., Iijima L., and Saito, N.
- Journal Title
  
  J. Neurochem 102
  
  Pages: 1635-1644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390064
[Journal Article] A novel PIP2 binding of εPKC and its contribution to the neurite induction ability2007
- Author(s)
  Shirai, Y., et al.
- Journal Title
  
  J. Neurochem. 102
  
  Pages: 1635-1644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390064
[Journal Article] Unphosphorylated MARCKS is involved in neurite initiation induced by insuline-like growth factor-l in SH-SY5Y cells.2006
- Author(s)
  Shiraishi, M. 他
- Journal Title
  
  J. Cell. Physiol. 209
  
  Pages: 1029-1038
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390065
[Journal Article] Unphosphorylated MARCKS is involved in neurite initiation induced by insuline-like growth factor-l in SH-SY5Y cells.2006
- Author(s)
  Shiraishi, M. et al.
- Journal Title
  
  J. Cell. Physiol. 209
  
  Pages: 1029-1038
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390065
[Journal Article] Unphosphorylated MARCKS is involved in neurite initiation induced by insuline-like growth factor-l in SH-SY5Y cells.2006
- Author(s)
  Shiraishi, M.他
- Journal Title
  
  J. Cell. Physiol. 209
  
  Pages: 1029-1038
- Data Source
  KAKENHI-PROJECT-17390065
[Journal Article] Ceramide-induced apoptosis by translocation, phosphorylation and activation of protein kinase C δ in the Golgi complex2004
- Author(s)
  Kajimoto T, Shirai Y, Sakai N, Yamamoto T, Matsuzaki H, Kikkawa U, Saito N
- Journal Title
  
  J.Biol.Chem 279
  
  Pages: 12668-12676
- Data Source
  KAKENHI-PROJECT-15570115
[Journal Article] Phospholipase A_2 products retain a neuron specific γ isoform of PKC on the plasma membrane through the C1 domain- a molecular mechanism for sustained enzyme activity2004
- Author(s)
  Yagi K, Shirai Y, Hirai M, Sakai N, Saito N
- Journal Title
  
  Neurochem Inter 45
  
  Pages: 39-47
- Data Source
  KAKENHI-PROJECT-15570115
[Journal Article] Activation and translocation of PKCδ is necessary for VEGF-induced ERK activation through KDR in HEK293T cells2004
- Author(s)
  Kuriyama M, Taniguchi T, Shirai Y, Sasaki A, Yoshimura A, Saito N
- Journal Title
  
  Biochem.Biophys.Res.Comm. 325
  
  Pages: 843-851
- Data Source
  KAKENHI-PROJECT-15570115
[Journal Article] Activation and translocation of PKCdelta is necessary for VEGF-induced ERK activation through KDR in HEK293T cells.2004
- Author(s)
  Kuriyama, M., Taniguchi, T., Shirai, Y., Sasaki, A., Yoshimura, A., Saito, N.
- Journal Title
  
  Biochem Biophys Res Commun 325
  
  Pages: 843-851
- Data Source
  KAKENHI-PROJECT-16659065
[Journal Article] プロテインキナーゼCのターゲティング機構2003
- Author(s)
  白井康仁
- Journal Title
  
  蛋白質・核酸・酵素 48
  
  Pages: 1241-1247
- NAID
  40005855527
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570115
[Journal Article] Direct binding of RaIA to PKCη and its crucial role in morphological change during keratinocytes differentiation.
- Author(s)
  Shirai, Y., et al.
- Journal Title
  
  Mol.Biol.Cell
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390070
[Journal Article] A novel PIP2 binding of εPKC and its contribution to the neurite induction ability.
- Author(s)
  Shirai, Y. et al.
- Journal Title
  
  J. Neurochem. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390065
[Patent] DGKγをターゲットとする抗アレルギー剤のスクリーニング方法2011
- Inventor(s)
  白井康仁、斎藤尚亮
- Industrial Property Rights Holder
  神戸大学
- Filing Date
  2011-06-27
- Data Source
  KAKENHI-PROJECT-21570139
[Patent] DGKγをターゲットとする抗アレルギー剤のスクリーニング方法2011
- Inventor(s)
  白井康仁, 斎藤尚亮
- Industrial Property Rights Holder
  神戸大学
- Filing Date
  2011-06-27
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] 膵β細胞I型DGKの糖尿病下での発現と血糖調節への影響の解析2019
- Author(s)
  松浦　朋哉、金子雪子、芹澤　環、澤谷　俊明、白井　康仁、石川　智久
- Organizer
  第21回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-17H02175
[Presentation] ジアシルグリセロールキナーゼalphaの局在及び活性と慢性白血病細胞の増殖に関する研究2017
- Author(s)
  5)山口侑香、木曽裕子、山本麻央、渡辺真以、斎藤尚亮、上田修司、山之上稔、白井康仁
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15K07002
[Presentation] ジアシルグリセロールキナーゼalpha活性化剤としての緑茶カテキンEGCgの経口投与による糖尿病性腎症改善効果の検証2017
- Author(s)
  林大輝,　上田修司,　山之上稔,　芦田均,　白井康仁
- Organizer
  日本農芸化学会2017年度大会
- Data Source
  KAKENHI-PROJECT-15K07002
[Presentation] 緑茶カテキンEGCgのメチル化による糖尿病性腎症改善効果の増強2017
- Author(s)
  林大輝,　上田修司,　山之上稔,　芦田均,　白井康仁
- Organizer
  農芸化学会関西・中四国・西日本支部2017年度合同大阪大会
- Data Source
  KAKENHI-PROJECT-15K07002
[Presentation] ジアシルグリセロールキナーゼalphaの核－細胞質間シャトリングの生理的意義の解明2016
- Author(s)
  渡辺真以, 木曽裕子, 上田修司, 山之上稔, 齋藤尚亮, 白井康仁
- Organizer
  農芸化学会関西支部例会（493回講演会）
- Place of Presentation
  京都大学　学友会館
- Year and Date
  2016-02-06
- Data Source
  KAKENHI-PROJECT-15K07002
[Presentation] The elucidation of the mechanism of lentinan-induced inflammatory suppression by visualizimg TNFR1 on the membrane2016
- Author(s)
  Kana Sakaguchi, Takashi Hashimoto, Toshiki Itoh, Yasuhito Shirai, and Masashi Mizuno
- Organizer
  Proceedings of the 20th international conference
- Place of Presentation
  The Joseph B. Martin Conference Center at Harvard Medical School, Boston (USA)
- Year and Date
  2016-09-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02897
[Presentation] レンチナンによって誘導されるTNFR1発現変化の可視化による炎症抑制機構の解明2016
- Author(s)
  坂口香奈、橋本堂史、伊藤俊樹、白井康仁、水野雅史
- Organizer
  日本食品科学工学会第63回大会
- Place of Presentation
  名城大学（愛知県・名古屋市）
- Data Source
  KAKENHI-PROJECT-15H02897
[Presentation] ジアシルグリセロールキナーゼalphaの218番目のチロシンリン酸化はドメイン間相互作用と高次構造を変化させる2015
- Author(s)
  脇阪昌明, 岩下智秋, 濱田大三, 祇園　景子, 上田修司, 山之上稔, 鶴田宏樹, 白井康仁
- Organizer
  BMB2015
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15K07002
[Presentation] チロシンリン酸化がジアシルグリセロールキナーゼalphaのドメイン間相互作用及び高次構造に与える影響2015
- Author(s)
  脇阪昌明, 岩下智秋, 濱田大三, 祇園景子, 上田修司, 山之上稔, 鶴田宏樹, 白井康仁
- Organizer
  農芸化学会関西支部例会（492回講演会）
- Place of Presentation
  神戸大学農学部
- Year and Date
  2015-12-05
- Data Source
  KAKENHI-PROJECT-15K07002
[Presentation] 細胞内ホスファチジン酸産生を時・空間的に解析できる簡便かつ新規な可視化プローブの開発2015
- Author(s)
  沖本航, 中井寛子, 伊藤俊樹, 森田真也, 上田修司, 山之上稔, 白井康仁
- Organizer
  第５７回日本脂質生化学会
- Place of Presentation
  一橋大学一橋講堂
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-15K07002
[Presentation] 創薬ターゲットとしてのジアシルグリセロールキナーゼ2012
- Author(s)
  白井康仁、齋藤尚亮
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  (京都府)国立京都国際会館(口頭発表、日本語)
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-21390070
[Presentation] Physiological function of nuclear DGKαunder serum depleted conditions2012
- Author(s)
  Y. Kiso, Y. Shirai, M. Sakuma, M. Ikeda, N. Saito
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] PKCηによるケラチノサイト分化機構の解明2012
- Author(s)
  白井康仁、盛岡祥子、佐久間恵、千田和広、斎藤尚亮
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都女子大学(京都府)
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] The role of diacylglycerol kinase in the degranulation from RBL-2H3 mast cells2012
- Author(s)
  M.Sakuma, Y.Shirai, T.Ueyama, N.Saito
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Diacylglycerol kinase as a possible drug target2012
- Author(s)
  Y.Shirai, N.Saito
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] ジアシルグリセロールキナーゼθの機能解析2012
- Author(s)
  上田修司、桐村悠佑、山之上稔、白井康仁
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都女子大学(京都府)
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Physiological function of nuclear DGKα under serum depleted conditions2012
- Author(s)
  Y.Kiso, Y.Shirai, M.Sakuma, M.Ikeda, N.Saito
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] 筋肉細胞におけるEGCgの糖代謝に及ぼす影響について2012
- Author(s)
  上田学、上田修司、白井康仁、芦田均
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都女子大学(京都府)
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Function of PKC and DGK in neurons2011
- Author(s)
  白井康仁
- Organizer
  2011 Taiwan-Japan Joint Symposium on Cell Signaling and Gene Regulation
- Place of Presentation
  台湾・台南
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] ジアシルグリセロールキナーゼβ(DGKβ)による神経特異的突起伸長機構の解明2011
- Author(s)
  中井寛子、加野拓也、上月健、斉藤尚亮、中嶋昭雄、吉川潮、上田修司、山之上稔、白井康仁
- Organizer
  第3回神戸大学バイオサイエンス研究会・若手研究者交流会
- Place of Presentation
  神戸大学(兵庫県)
- Year and Date
  2011-09-06
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Function of PKC and DGK in neurons2011
- Author(s)
  白井康仁
- Organizer
  2011 Taiwan-Japan Joint Symposium on Cell Signaling and Gene Regulation
- Place of Presentation
  台南(台湾)
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] 異なるチロシンリン酸化によるジアシルグリセロールキナーゼalphaの局在調節機構2011
- Author(s)
  白井康仁、池田もも、佐久間恵、木曽裕子、斎藤尚亮
- Organizer
  第119回薬理学会近畿支部大会
- Place of Presentation
  名古屋
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Novel phosphorylation site(s) of cofilin by PKCα and its negative role in the degranulation from RBL-2H3 mast cells2011
- Author(s)
  Sakuma, M., Shirai, Y., Yoshino K., Kuramasu, M., Nakamura, T., Mizuno, K., Hide, I., Nakata, Y., Saito, N.
- Organizer
  The American society for cell biology
- Place of Presentation
  デンバー、米国
- Data Source
  KAKENHI-PROJECT-21390070
[Presentation] ジアシルグリセロールキナーゼ・の核移行と細胞周期制御に関する研究2-c-Ablによるチロシンリン酸化サイトの同定-2011
- Author(s)
  白井康仁、池田もも、木曽裕子、佐久間恵、齋藤尚亮
- Organizer
  第53回日本脂質生化学会
- Place of Presentation
  東京
- Year and Date
  2011-05-12
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Regulation of diacylglycerolkinase by phosphorylation2011
- Author(s)
  Y.Shirai, N.Saito
- Organizer
  Fifty-Second International Symposium on "Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues"
- Place of Presentation
  ボローニャ(イタリア)
- Year and Date
  2011-09-26
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Regulation of diacylglycerolkinase by phosphorylation2011
- Author(s)
  白井康仁
- Organizer
  Fifty-Second International Symposium on "Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues"
- Place of Presentation
  イタリア・ボローニャ
- Year and Date
  2011-09-26
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] ジアシルグリセロールキナーゼαの核移行と細胞周期制御に関する研究2-c-Ablによるチロシンリン酸化サイトの同定-2011
- Author(s)
  白井康仁、池田もも、木曽裕子、佐久間恵、齋藤尚亮
- Organizer
  第53回日本脂質生化学会
- Place of Presentation
  ホテル東京ガーデンパレス(東京都)
- Year and Date
  2011-05-12
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Impairment of cognitive function and lithium-sensitive behavior of knockout mice of neuron-enriched subtype of DG kinase2011
- Author(s)
  Y Shirai, T Kouzuki, K Kakefuda, A Ohyagi, K Horie, S Moriguchi, S Morita, M Shimazawa, K Fukunaga, J Takeda, N Saito, H Hara
- Organizer
  First annual meeting of International Society of Radiation Neurobiology
- Place of Presentation
  Maebashi, Japan
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] 異なるチロシンリン酸化によるジアシルグリセロールキナーゼalphaの局在調節機構2011
- Author(s)
  白井康仁、池田もも、佐久間恵、木曽裕子、斎藤尚亮
- Organizer
  第119回薬理学会近畿支部大会
- Place of Presentation
  ウィンクあいち(愛知県)
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Visualization of protein kinase C and diacylglycerol kinase in living cells2010
- Author(s)
  Y.Shirai, N.Saito
- Organizer
  28^<th> JES summer seminar on Endocrinology & Metabolism.
- Place of Presentation
  長崎大学(長崎県)(招待講演)
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Correlation between abnormal behavior and lipids contents of DGKβ KO mice2010
- Author(s)
  Y.Shirai, N.Saito
- Organizer
  The 5^<th> international mini-symposium on diacylglycerol kinase (DGK).
- Place of Presentation
  神戸本学(兵庫県)
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Membrane lipids control by neuron-enriched diacylglycerol kinaseβ is important for spine formation and cognitive function.2010
- Author(s)
  Y.Shirai, T.kouzuki, K.Kakefuda, S.Moriguchi, A.Oyagi, K.Horie S.Morita, M.Shimazawa, K.Fukunaga, J.Takeda, N.Saito, H.Hara
- Organizer
  Keystone symposia "Bioactive lipids : biochemistry and diseases
- Place of Presentation
  ウェスティン都京都(京都府)(招待講演)
- Year and Date
  2010-06-09
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Membrane lipids control by neuron-enriched diacylglycerol kinase・is important for spine formation and cognitive function2010
- Author(s)
  Y. Shirai, T. Kouzuki, K. Kakefuda, S. Moriguchi, A. Oyagi, K. Horie, S. Morita, M. Shimazawa, K. Fukunaga, J. Takeda, N. Saito and H. Hara
- Organizer
  Bioactive lipids : biochemistry and diseases
- Year and Date
  2010-06-09
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Nuclear diacylglycerol signaling regulated by nuclear-cytoplasmic shuttling of diacylglycerol kinase and its correlation to cell cycle control2010
- Author(s)
  Y. Shirai and N. Saito
- Organizer
  BMB2010
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Correlation between abnormal behavior and lipids contents of DGK・KO mice2010
- Author(s)
  Y. Shirai
- Organizer
  The 5^<th> international mini-symposium on diacylglycerol kinase
- Place of Presentation
  DGK
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Nuclear diacylglycerol signaling regulated by nuclear-cytoplas mic shuttling of diacylglycerol kinase α and its correlation to cell cycle control2010
- Author(s)
  Y.Shirai, N.Saito
- Organizer
  BMB2010
- Place of Presentation
  神戸ポートヲイランド(兵庫県)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Essential role of diacylglycerol kinase beta(DGKβ)in neurite spine formation, cognitive function and memory2009
- Author(s)
  白井康仁
- Organizer
  Neuroscience 2009
- Place of Presentation
  McCormick Place Convention Center(Chicago, USA)
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Important role of diacylglycerol kinase・in spine formation and memory2009
- Author(s)
  白井康仁
- Organizer
  日本神経科学大会
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] ジアシルグリセロールキナーゼ・ノックアウトマウスはスパイン形成異常と記憶障害を示す-スパイン形成における脂質シグナリングの重要性-2009
- Author(s)
  白井康仁
- Organizer
  脂質生化学会
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] ジアシルグリセロールキナーゼβノックアウトマウスはスパイン形成異常と記憶障害を示す-スパイン形成における脂質シグナリングの重要性-2009
- Author(s)
  白井康仁
- Organizer
  脂質生化学会
- Place of Presentation
  ウイル愛知(愛知県)
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Essential role of diacylglycerol kinase beta(DGK・・in neurite spine formation, cognitive function and memory2009
- Author(s)
  Y, Shirai
- Organizer
  Neuroscience 2009
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] Essential role of diacylglycerol kinase beta(DGKb) in neurite spine formation2009
- Author(s)
  Y, Shirai
- Organizer
  Japan-Taiwan Joint Symposium on Cell Signaling and Gene Regulation
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] 気分障害と神経特異的ジアシルグリセロール2009
- Author(s)
  白井康仁、齋藤尚亮
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19390064
[Presentation] Essential role of diacylglycerol kinase beta(DGKβ)in neurite spine for mation, coginitive function and memory2009
- Author(s)
  白井康仁
- Organizer
  Japan-Taiwan Joint Symposium on Cell Signaling and Gene Regulation
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2009-11-12
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] 神経特異的ジアシルグリセロールキナーゼDGKβの機能解析2009
- Author(s)
  上月健、白井康仁、掛札賢一、大八木篤、堀江恭二、嶋澤雅光、福永浩司、竹田潤二、齋藤尚亮、原英彰
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19390064
[Presentation] Important role of diacylglycerol kinase β in spine formation and memory2009
- Author(s)
  白井康仁
- Organizer
  日本神経科学大会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-21570139
[Presentation] 神経特異的ジアシルグリセロールキナーゼDGKβの機能解析2008
- Author(s)
  白井康仁、上月健、掛札賢一、大八木篤、堀江恭二、嶋澤雅光、竹田潤二、齋藤尚亮、原英彰
- Organizer
  BMB2008(第31回日本分子生物学会年会・第81回日本生化学大会合同大会)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19390064
[Presentation] Differential regulation of dual oxidase 1 by dual activator 1 splicing variants2008
- Author(s)
  Tsujibe,S., Ueyama,T., Shirai,Y., Leto L. Thomas., Saito,N.
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19390064
[Presentation] Clarification of regulatory mechanism of Orail(SOCs)by PKC2007
- Author(s)
  Kawasaki,T., Ueyama,T., Shirai,Y., Saito, N.
- Organizer
  14^<th> Congress of Ca2+ binding proteins & Ca2+ function in health & disease
- Place of Presentation
  La Palma Spain
- Data Source
  KAKENHI-PROJECT-19390064
[Presentation] 核内脂質シグナル及び核移行蛋白質の可視化システムを用いた細胞周期機構の解明-DGK の核-細胞質間移行機構と核内における機能に着目して-2007
- Author(s)
  白井康仁、松原岳大、齋藤尚亮
- Organizer
  第49回日本脂質生化学会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-19390064
[Presentation] D核内脂質シグナル及び核移行蛋白質の可視化システムを用いた細胞周期機構の解明-DGKの核-細胞質間移行機構と核内における機能に着目して2007
- Author(s)
  白井康仁、松原岳大、齋藤尚亮
- Organizer
  第49回日本脂質生化学会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-19390064
[Presentation] ヒトケラチノサイトにおけるTNF-αによるNGF 分泌促進作用とそのシグナル2007
- Author(s)
  伝達機能, 高岡幸二、白井康仁、齋藤尚亮
- Organizer
  第111回日本薬理学会近畿部会
- Place of Presentation
  名古屋
- Year and Date
  2007-06-15
- Data Source
  KAKENHI-PROJECT-19390064
[Presentation] c-Ab1, a tyrosine kinase involved in chronic myeloid leukemia, regulates nucleo-cytoplasmic shuttling of DGKαand cell cycle2007
- Author(s)
  Shirai,Y., Matsubara,T., Saito, N.
- Organizer
  FASEB Summer Research Conferences
- Place of Presentation
  Indian Wells CA
- Data Source
  KAKENHI-PROJECT-19390064
[Presentation] DG-PKCシグナル系の可視化とその異常による疾患2007
- Author(s)
  齋藤尚亮、白井康仁、松原岳大、足立直子、高橋英之、酒井規雄
- Organizer
  第49回日本脂質生化学会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-19390064
[Presentation] P2Y受容体を介するγPKCのオシレーション機構の解明2006
- Author(s)
  芦田典明、上山健彦、力武恭子、白井康仁、衛藤三佳、近藤威、甲村英二、齋藤尚亮
- Organizer
  第113回日本薬理学会近畿部会
- Place of Presentation
  岡山
- Year and Date
  2006-06-20
- Data Source
  KAKENHI-PROJECT-19390064
[Presentation] RalAはηPKCによるケラチノサイトの扁平化に必須である。2006
- Author(s)
  白井康仁、盛岡祥子、大辻千裕、吉野健一、酒井規雄、上山健彦、齋藤尚亮
- Organizer
  第113回日本薬理学会近畿部会
- Place of Presentation
  岡山
- Year and Date
  2006-06-20
- Data Source
  KAKENHI-PROJECT-19390064

1. SAITO Naoaki (60178499)

# of Collaborated Projects: 18 results

# of Collaborated Products: 39 results
2. SAKAI Norio (70263407)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. UEYAMA Takehiko (80346254)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
4. TANIGUCHI Taizo (70346253)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 柏木香保里 (10372666)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TSURUTA HIROKI (20346282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. Mishima Masaki (70346310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Mizuno Masashi (00212233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. Ishikawa Tomohisa (10201914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 天野託 (10294547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 松林弘明 (60165850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 伊藤隆 (80261147)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 金子雪子 (00381038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 洲崎敏伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 芦田均

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 坂根郁夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 八月朔日泰和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIRAI YASUHITO 白井 康仁

Ysuhito Shirai 白井 康仁

Shirai Yasuhito 白井 康仁

SHIRAI Yasuhito 白井 康仁

白井 康仁 シライ ヤスヒト

Research Projects

Research Products

Co-Researchers

Mechanism of DG kinase-mediated improvement of diabetic nephropathy by food ingredients and its applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive investigation of molecular mechansim of intracellular localization of DG kinase as an example of general enzmesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of DG kinase functions related to PKC and its application for future drug.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

核内脂質シグナル及び核移行蛋白質の可視化システムを用いた細胞周期制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

SHIRAI YASUHITO 白井康仁

Ysuhito Shirai 白井康仁

Shirai Yasuhito 白井康仁

SHIRAI Yasuhito 白井康仁

白井康仁シライヤスヒト