ARAI Masahiro 新井雅裕

Researcher Number	60271566
Affiliation (based on the past Project Information) *help	2002 – 2003: The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 2000 – 2001: 東京大学, 医学部・附属病院, 助手 1996: 東京大学, 医学部・附属病院, 助手 1995 – 1996: 東京大学, 医学部(病), 助手
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology
Keywords	Principal Investigator 肝移植 / 虚血再灌流障害 / ischemic preconditioning / ISCHEMIC PRECONDITIONING / Kupffer細胞 / 活性酸素 / アデノシン / 活性酵素 / LIVER TRASNPLANTATION / ISCHEMIA REPERFUSION … More / KUPFFER CELLS / SUPEROXIDE / ADENOSINE / 虚血再潅流障害 / ISCHEMIA / REPERFUSION INJURY / LIVER TRANSPLANTATION … More Except Principal Investigator HGF / 肝細胞 / 星細胞 / スフィンゴシン1リン酸 / HEPATIC STELLATE CELLS / TGFα / Hepatocytes / Edg-5(S1P_2) / Rho / Leucine / 伊東細胞 / 筋線維芽細胞 / 肝線維化 / CUBドメイン / RNA結合ドメイン / 脂肪貯蔵細胞 / クローニング / 分子生物学 / 活性化 / 形質転換 / Ito cell / Stellate cell / Fat-storing cell / Myofibroblast / Liver fibrogenesis / CUB domain / RNA-binding domain / 門脈圧亢進症 / リゾフォスファチジン酸 / スフィンゴシンコリン酸 / PORTAL HYPERTENSION / SPHINGOSINE 1-PHOSPHATE / LYSOPHOSPHATIDIC ACID / 増殖 / 機能 / proliferation / functions / Lysophosphatidic acid / 肝星細胞 / Autotaxin / Lipid phosphate phosphohydrolase / 低分子量G淡白質Rho / Lysophospholipase D / Auto taxin / LYSOPHOSHATIDIC ACID / AUTOTAXIN / LIPID PHOSPHATE PHOSPHOHYDROLASE / 肝再生 / EDG5 / sphingosine 1-phosphate / liver regeneration / ロイシン Less

Induction of hepatocyte growth factor by physiological agents : its effects on hepatocyte proliferation and protein production
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Functional Analysis of The Biological Activities of a Lipid Mediator, Lysophoshatidie Acid, on The Pathogenesis of Liver Fibrosis
- Principal Investigator
  
  YANASE Mikio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Elucidation of the mechanism of the inhibitory effect of sphingosine 1-phosphate on hepatocyte proliferation and the significance in liver regeneration
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
LIVER PROTECTION AGAINST ISCHEMIAJREPERFUSION INJURY BY ISCHEMIC PRECONDITIONINGPrincipal Investigator
- Principal Investigator
  
  ARAI Masahiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  THE UNIVERSITY OF TOKYO
Significance of growth factors for Hepatocyte proliferation and functions
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
PORTAL HYPERTENSION-ELUCIDATION OF THE MECHANISM IN THE LIGHT OF FUNCTIONAL ABNORMALITIES OF HEPATIC STELLATE CELLS AND DEVELOPMENT OF THERAPEUTIC STRATEGY
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  THE UNIVERSITY OF TOKYO
MEASURES AGAINST HEPATIC FAILURE AFTER LIVER TRANSPLANTATION : BASIC INVESTIGATION ON PRECONDITIONING OF THE DONOR LIVERPrincipal Investigator
- Principal Investigator
  
  ARAI Masahiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  THE UNIVERSITY OF TOKYO
Cloning and characterization of newly described proteins from a fat-storing cell library : their significance in the activation of the cells.Principal Investigator
- Principal Investigator
  
  OGATA Itsuro, 新井雅裕
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo

All 2004

All Journal Article

[Journal Article] Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats.2004
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, et al.
- Journal Title
  
  Gastroenterology 127
  
  Pages: 1488-1496
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation.2004
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, Arai M, et al.
- Journal Title
  
  Biochem Biophys Res Commun 320
  
  Pages: 754-759
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation.2004
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, Arai M, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 320
  
  Pages: 754-759
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Treatment with leucine stimulates the production of hepatocyte growth factor in vivo.2004
- Author(s)
  Tomiya T, Inoue Y, Yanase M, Arai M, Ikeda H et al.
- Journal Title
  
  Biochem Biophys Res Commun. 322
  
  Pages: 772-777
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats.2004
- Author(s)
  Tajima K, Arai M, Ikeda H, Tomiya T, Yanase M, et al.
- Journal Title
  
  Gastroenterology 127
  
  Pages: 1488-1496
- Data Source
  KAKENHI-PROJECT-15590625

1. IKEDA Hitoshi (80202422)

# of Collaborated Projects: 8 results

# of Collaborated Products: 5 results
2. TOMITA Tomoaki (90227637)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
3. YANASE Mikio (50334397)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
4. OGATA Itsuro (80169169)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YAMAOKA Miho (50261962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ARAI Masahiro 新井 雅裕

Research Projects

Research Products

Co-Researchers

Induction of hepatocyte growth factor by physiological agents : its effects on hepatocyte proliferation and protein production

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional Analysis of The Biological Activities of a Lipid Mediator, Lysophoshatidie Acid, on The Pathogenesis of Liver Fibrosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism of the inhibitory effect of sphingosine 1-phosphate on hepatocyte proliferation and the significance in liver regeneration

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

LIVER PROTECTION AGAINST ISCHEMIAJREPERFUSION INJURY BY ISCHEMIC PRECONDITIONINGPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Significance of growth factors for Hepatocyte proliferation and functions

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PORTAL HYPERTENSION-ELUCIDATION OF THE MECHANISM IN THE LIGHT OF FUNCTIONAL ABNORMALITIES OF HEPATIC STELLATE CELLS AND DEVELOPMENT OF THERAPEUTIC STRATEGY

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MEASURES AGAINST HEPATIC FAILURE AFTER LIVER TRANSPLANTATION : BASIC INVESTIGATION ON PRECONDITIONING OF THE DONOR LIVERPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cloning and characterization of newly described proteins from a fat-storing cell library : their significance in the activation of the cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Treatment with leucine stimulates the production of hepatocyte growth factor in vivo.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats.2004

Author(s)

Journal Title

Data Source

ARAI Masahiro 新井雅裕