TOMIYA Tomoaki 冨谷智明

… Alternative Names

Researcher Number	90227637
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2010 – 2013: The University of Tokyo, 医学部附属病院, 特任講師 2007 – 2009: 東京大学, 医学部附属病院, 助教 2008: 東京大学, 医学部・附属病院, 特任講師 2007: The University of Tokyo, Faculty of Medicine, Assistant 2006: The University of Tokyo, Faculty of Medicine, Project Lecturer, 医学部附属病院, 特任講師 … More
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology
Keywords	Principal Investigator HGF / 再生医学 / 栄養学 / トランスレイショナルリサーチ / 生理活性 / 肝細胞 / TGFα / Hepatocytes / Leucine / 内科 … More Except Principal Investigator スフィンゴシン1リン酸 / 肝再生 / 虚血再灌流障害 / Ischemic preconditioning / 肝障害 / 肝細胞膜 / liver regeneration / 肝細胞 / Rho / 移植・再生医療 / 酸化ストレス / Kupffer細胞 / 肝線維化 / 門脈圧亢進症 / 劇症肝炎 / plasma membrane / TGFα / 肝星細胞 / Rho-kinase / ICAM-1 / リゾフォスファチジン酸 / HEPATIC STELLATE CELLS / Lysophosphatidic acid / Autotaxin / Edg-5(S1P_2) / NADPH oxidase / 活性酸素ラジカル(ROS) / 脂質過酸化 / 生理活性脂質 / 肝臓病学 / 肝臓学 / 血管内凝固 / マクロファ-ジ / オルニシン脱炭酸酵素 / 内皮細胞 / 培養肝細胞 / ポリアミン代謝 / オルニシン脱炭酵素 / 分子生物学 / 肝再生促進因子 / fulminant hepatitis / intravascular coagulation / macrophage / ornithine decarboxylase / cultured hepatocyte / polyamine / 肝細胞増殖因子 / プトレスシン / TGFβ / Hepatocyte plasma membrane / Hepatocyte growth factor / Putrescine / TGFbeta / 細胞増殖 / 肝細胞増殖 / 蛋白 / hepatocytes / cell growth / 伊東細胞 / レチノール結合蛋白 / コラーゲン / STELLATE CELL / RETINOL BINDING PROTEIN / COLLAGEN / proTGFα / 成熟型TGFα / 非成熟型TGFα / 肝細胞癌 / 分化度 / 診断法 / pro TGFα / mature form of TGFα / immature form of TGFα / hepatocellular carcinoma / differentiation / diagnostic method / 細胞外マトリックス / Rho-Kinase / 硬変肝 / リン酸化 / Rho Kinase / extracellular matrix / cirrgotic liver / phospholylation / Hepatic stellate cell / 接着分子 / マクロファージ活性化 / HEPATOCYTE / ADHESION MOLECULE / LIVER INJURY / MACROPHAGE ACTIVATION / 星細胞 / スフィンゴシンコリン酸 / PORTAL HYPERTENSION / SPHINGOSINE 1-PHOSPHATE / LYSOPHOSPHATIDIC ACID / Lipid phosphate phosphohydrolase / 低分子量G淡白質Rho / Lysophospholipase D / Auto taxin / LYSOPHOSHATIDIC ACID / AUTOTAXIN / LIPID PHOSPHATE PHOSPHOHYDROLASE / EDG5 / sphingosine 1-phosphate / ischemic preconditioning / 肝移植 / 虚血再潅流障害 / ISCHEMIA / REPERFUSION INJURY / ISCHEMIC PRECONDITIONING / LIVER TRANSPLANTATION / 活性酸素 / reactive oxygen species(ROS) / Ischemia / reperfusion injury / Kupffer cells / Oxygen radicals / Oxidative stress / Transplantation and regeneration / オートタキシン / 肝硬変 / Liver fibrosis / Liver cirrhosis / Liver damage Less

Stimulation of liver regeneration and function by IGF-IPrincipal Investigator
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
A novel treatment for liver injury by modulation oflipid mediator effects
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Induction of IGF-I production by amino acids in the liver : Its significance in the cirrhotic liverPrincipal Investigator
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
短時間の虚血再潅流による酸化ストレスを介した肝細胞保護作用の制御・機序
- Principal Investigator
  
  TEJIMA Kazuaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Elucidation of a role of sphingosine 1-phosphate on liver damage
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Modulation by amino acids of the expression of factors produced by hepatic stellate cells : its implication in injured liverPrincipal Investigator
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Research for mechanisms of induction of hepatic ischemic tolerance by ischemic preconditioning.
- Principal Investigator
  
  TEJIMA Kazuaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Elucidation of the clinical significance of autotaxin and lysophosphatidic acid in liver diseases.
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Induction of hepatocyte growth factor by physiological agents : its effects on hepatocyte proliferation and protein productionPrincipal Investigator
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Functional Analysis of The Biological Activities of a Lipid Mediator, Lysophoshatidie Acid, on The Pathogenesis of Liver Fibrosis
- Principal Investigator
  
  YANASE Mikio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Elucidation of the mechanism of the inhibitory effect of sphingosine 1-phosphate on hepatocyte proliferation and the significance in liver regeneration
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
LIVER PROTECTION AGAINST ISCHEMIAJREPERFUSION INJURY BY ISCHEMIC PRECONDITIONING
- Principal Investigator
  
  ARAI Masahiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  THE UNIVERSITY OF TOKYO
Significance of growth factors for Hepatocyte proliferation and functionsPrincipal Investigator
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
PORTAL HYPERTENSION-ELUCIDATION OF THE MECHANISM IN THE LIGHT OF FUNCTIONAL ABNORMALITIES OF HEPATIC STELLATE CELLS AND DEVELOPMENT OF THERAPEUTIC STRATEGY
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  THE UNIVERSITY OF TOKYO
Diagnostic method for differentiation of hepatocellular carcinoma : Determination of immature TGFα in blood and urine.
- Principal Investigator
  
  OGATA Itsuro
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
Extracellular matrix in liver cirrhosis : its abnormality and influence on liver functions.
- Principal Investigator
  
  OGATA Itsuro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
HEPATOCYTES AND ADHESION MOLECULE ICAM-1 : ITS EXPRESSION AND SIGNIFICANCE FOR LIVER INJURY.
- Principal Investigator
  
  OHNO Akihiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
THERAPY FOR HEPATIC FIBROSIS BY TARGETED DELIVERY OF ANTI-FIBROTIC AGENTS TO HEPATIC STELLATE CELLS
- Principal Investigator
  
  MASAKI Naohiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  UNIVERSITY OF TOKYO
purification of growth stimulatory factor in rat liver plasma membrane
- Principal Investigator
  
  HIRATA Keiichi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
Purification of hepatocyte comitogenic factor in plasma membrane and its action site (s) in hepatocyte proliferation.
- Principal Investigator
  
  FUJIWARA Kenji
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
Factors Associated with Insufficient Liver Regeneration in Fulminant Hepatic Failure
- Principal Investigator
  
  FUJIWARA Kenji
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation

[Journal Article] Expression ofα-taxilin in the murine gastrointestinal tract : potential implication in cell proliferation2014
- Author(s)
  Horii Y, Sakane H, Nogami S, Ohtomo N, Tomiya T, Shirataki, H
- Journal Title
  
  Histochem Cell Biol
  
  Volume: 141 Pages: 165-180
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Treatment for minimal hepatic encephalopathy : Are we ghost busters?2014
- Author(s)
  Tomiya T
- Journal Title
  
  Hepatol Res
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Expression of α -taxilin in the murine gastrointestinal tract : potential implication in cell proliferation2014
- Author(s)
  Horii Y, Sakane H, Nogami S, Ohtomo N, Tomiya T, Shirataki H.
- Journal Title
  
  Histochem. Cell Biol
  
  Volume: 141 Pages: 165-180
- DOI
  10.1007/s00418-013-1147-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590961, KAKENHI-PROJECT-23659403
[Journal Article] High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential2014
- Author(s)
  Uranbileg B, Enooku K, Soroida Y, Ohkawa R, Kudo Y, Nakagawa H, Tateishi R, Yoshida H, Shinzawa S, Moriya K, Ohtomo N, Nishikawa T, Inoue Y, Tomiya T, Kojima S, Matsuura T, Koike K, Yatomi Y, Ikeda H.
- Journal Title
  
  Int J Cancer
  
  Volume: 134 Pages: 2189-2198
- DOI
  10.1002/ijc.28547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590961, KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-25460981
[Journal Article] Treatment for minimal hepatic encephalopathy: Are we ghost busters?2014
- Author(s)
  Tomiya T
- Journal Title
  
  Hepatol Res
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly-malignant potential2014
- Author(s)
  Uranbileg B, Enooku K, Soroida Y, Ohkawa R, Kudo Y, Nakagawa H, Tateishi R, Yoshida H, Shinzawa S, Moriya K, Ohtomo N, Nishikawa T, Inoue Y, Tomiya T, Koike K, Yatomi Y, Ikeda H
- Journal Title
  
  Int J Cancer
  
  Volume: 134 Pages: 2189-2198
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Induction of p53-dependent p21 limits proliferative activity of rat hepatocytes in the presence of hepatocyte growth factor2013
- Author(s)
  Inoue Y, Tomiya T, Nishikawa T, Ohtomo N, Tanoue Y, Ikeda H, Koike K
- Journal Title
  
  PLoS One
  
  Volume: 8
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Induction of p53-dependent p21 limits proliferative activity of rat hepatocytes in the presence of hepatocyte growth factor.2013
- Author(s)
  Inoue Y, Tomiya T, Nishikawa T, Ohtomo N, Tanoue Y, Ikeda H, Koike K.
- Journal Title
  
  PLoS One.
  
  Volume: 8
- DOI
  10.1371/journal.pone.0078346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Interaction ofα-taxilin localized on intracellular components with the microtubule cytoskeleton2012
- Author(s)
  Horii Y, Nogami S, Kawano Y, Kaneko-Kawano T, Ohtomo N, Tomiya T, Shirataki H
- Journal Title
  
  Cell Struct Funct
  
  Volume: 37 Pages: 111-26
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents.2012
- Author(s)
  Kegeyama Y
- Journal Title
  
  Hepatology
  
  Volume: 56 Pages: 1427-1438
- DOI
  10.1002/hep.25780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590284, KAKENHI-PROJECT-22590716, KAKENHI-PROJECT-23590961, KAKENHI-PROJECT-23591213, KAKENHI-PROJECT-23659170, KAKENHI-PUBLICLY-23116509
[Journal Article] Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents2012
- Author(s)
  Kageyama Y, Ikeda H, Watanabe N, Nagamine M, Kusumoto Y, Yashiro M, Satoh Y, Shimosawa T, Shinozaki K, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Yokota H, Koyama T, Ishimaru K, Okamoto Y, Takuwa Y, Koike K, Yatomi Y
- Journal Title
  
  Hepatology
  
  Volume: 56 Pages: 1427-38
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Interaction of α-taxilin localized on intracellular components with the microtubule cytoskeleton.2012
- Author(s)
  Horii Y, Nogami S, Kawano Y, Kaneko-Kawano T, Ohtomo N, Tomiya T, Shirataki H.
- Journal Title
  
  Cell Struct Funct
  
  Volume: 37 Pages: 112-126
- NAID
  130004137583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Prediction of hepatocellular carcinoma development by plasma ADAMTS13 in chronic hepatitis B and C2011
- Author(s)
  Ikeda H, Tateishi R, Enooku K, Yoshida H, Nakagawa H, Masuzaki R, Kondo Y, Goto T, Shiina S, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Ono T, Koike K, Yatomi Y
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev
  
  Volume: 20 Pages: 2204-11
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Autotaxin as a novel serum marker of liver fibrosis2011
- Author(s)
  Nakagawa H, Ikeda H, Nakamura K, Ohkawa R, Masuzaki R, Tateishi R, Yoshida H, Watanabe N, Tejima K, Kume Y, Iwai T, Suzuki A, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki J, Koike K, Yatomi Y
- Journal Title
  
  Clin Chim Acta
  
  Volume: 412 Pages: 1201-6
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Autotaxin as a novel serum marker of liver fibrosis.2011
- Author(s)
  Nakagawa H, Ikeda H, Nakamura K, Watanabe N, Tejima K, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki J, Koike K, Yatomi Y.
- Journal Title
  
  Clin Chim Acta
  
  Volume: 412 Pages: 1201-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Prediction of hepatocellular carcinoma development by plasma ADAMTS13 in chronic hepatitis B and C.2011
- Author(s)
  Ikeda H, Tateishi R, Enooku K, Yoshida H, Nakagawa H, Masuzaki R, Kondo Y, Goto T, Shiina S, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Ono T, Koike K, Yatomi Y.
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev
  
  Volume: 20 Pages: 2204-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590961
[Journal Article] Sex difference in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.2010
- Author(s)
  Tomiya T.
- Journal Title
  
  Hepatol Res
  
  Volume: 40 Pages: 108-110
- NAID
  10027407074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Increased production of ADAMTS13 in hepatic stellate cells contributes to enhanced plasma ADAMTS13 activity in rat models of cholestasis and steatohepatitis.2010
- Author(s)
  Watanabe N, Ikeda H, Kume Y, Satoh Y, Kaneko M, Takai D, Tejima K, Nagamine M, Mashima H, Tomiya T, Noiri E, Omata M, Matsumoto M, Fujimura Y, Yatomi Y
- Journal Title
  
  Thromb Haemost 102
  
  Pages: 389-396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Sex difference in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.2010
- Author(s)
  Tomiya T
- Journal Title
  
  Hepatol Res 40
  
  Pages: 108-110
- NAID
  10027407074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Impaired liver regeneration in acute liver failure : the significance of cross-communication of growth associated factors in liver regeneration.2010
- Author(s)
  Tomiya T, Omata M, Imamura H, Fujiwara K
- Journal Title
  
  Hepatol Res 38
- NAID
  10025323134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Expression of alpha-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor.2010
- Author(s)
  Ohtomo N, Tomiya T, Tanoue Y, Inoue Y, Nishikawa T, Ikeda H, Seyama Y, Kokudo N, Shibahara J, Fukayama M, Koike K, Shirataki H, Fujiwara K
- Journal Title
  
  Int J Oncol 37
  
  Pages: 1417-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Expression of alpha-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor.2010
- Author(s)
  Ohtomo N, Tomiya T, et al
- Journal Title
  
  Int J Oncol
  
  Volume: 37 Pages: 1417-1423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] plasma level of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C.2010
- Author(s)
  Ikeda H, Ohkawa R, Watanabe N, Nakamura K, Kume Y, Nakagawa H, Yoshida H, Okubo S, Yokota H, Tomiya T, et al.
- Journal Title
  
  Clin Chim Acta
  
  Volume: 416 Pages: 765-770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2.2010
- Author(s)
  Ikeda H, Watanabe N, Ishii I, Shimosawa T, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Iitsuka S, Fujita R, Omata M, Chun J, Yatomi Y
- Journal Title
  
  J Lipid Res 50
  
  Pages: 556-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Plasma level of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C.2010
- Author(s)
  Ikeda H, Ohkawa R, Watanabe N, Nakamura K, Kume Y, Nakagawa H, Yoshida H, Okubo S, Yokota H, Tomiya T, Nishikawa T, Ohtomo N, Tanoue Y, Koike K, Yatomi Y
- Journal Title
  
  Clin Chim Acta 411
  
  Pages: 765-770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2.2009
- Author(s)
  Ikeda H, Watanabe N, Ishii I, Shimosawa T, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, et al.
- Journal Title
  
  J Lipid Res 50
  
  Pages: 556-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Increased production of ADAMTS13 in hepatic stellate cells contributes to enhanced plasma ADAMTS13 activity in rat models of cholestasis and steatohepatitis.2009
- Author(s)
  Watanabe N, Ikeda H, Kume Y, Satoh Y, Kaneko M, Takai D, Tejima K, Nagamine M, Mashima H, Tomiya T, et al.
- Journal Title
  
  Thrombo Haemost 102
  
  Pages: 389-396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Sphingosine1-phosphate regulates regeneration and fibrosisafter liver injury via sphingosine 1-phosphate receptor 2(S1P_2)2009
- Author(s)
  Ikeda H., Watanabe N., Ishii I., Shimosawa T.,Kume Y., Tomiya T., Inoue Y., Nishikawa T., Ohtomo N., Tanoue Y., Iitsuka S., Fujita R., Omata M., Chun J., Yatomi Y.
- Journal Title
  
  Journal of Lipid Research
  
  Pages: 556-564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590750
[Journal Article] Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injuryvia sphingosine 1-phosphate receptor 2.2008
- Author(s)
  Ikeda H, Watanabe. N, Ishii I, Shimosawa T, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, et al.
- Journal Title
  
  J Lipid Res 50
  
  Pages: 556-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Impaired liver regeneration in acute liver failure: the significance of cross-communication of growth associated factors in liver regeneration.2008
- Author(s)
  Tomiya T, Omata M, Imamura H, Fuiiwara K
- Journal Title
  
  Hepatol Res 38
  
  Pages: 29-33
- NAID
  10025323134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590761
[Journal Article] Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells.2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, et. al.
- Journal Title
  
  World J Gastroenterol 13(38)
  
  Pages: 5071-5078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590749
[Journal Article] Effect of rapamycin on hepatocyte function and proliferation induced by growth factors.2007
- Author(s)
  Tomiya T, Yamaoka M, Inoue Y, Nishikawa T, Yanase M, Ikeda H, Tejima K, Nagashima K, Watanabe N, Omata M, Fujiwara K.
- Journal Title
  
  Chemotherapy 53
  
  Pages: 59-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells.2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, moue Y, Nishikawa T, Watanabe N, Ohtomo N, Omata M, fujiwara K.
- Journal Title
  
  World J Gastroenterol 13
  
  Pages: 5071-5078
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway2007
- Author(s)
  Tomiya T, Nishikawa T, Inoue Y, Ohtomo N, Ikeda H, Tejima K, Watanabe N, Tanoue Y, Omate, M, Fujiwara K.
- Journal Title
  
  Biochem Biophys Res Common 358
  
  Pages: 176-180
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Expression of transforming growth factor-alpha and-beta in hepatic lobes after hemihepatic portal vein embolization2007
- Author(s)
  Kusaka K, Imamura H, Tomiya T, Takayama T, Makuuchi M.
- Journal Title
  
  Dig Dis Sci 51
  
  Pages: 1404-1412
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Stimulation by glutamine and proline of HGF production in hepatic stellate cells.2007
- Author(s)
  Nishikawa T, Tomiya T, Ohtomo N, Inoue Y, Ikeda H, Tejima K, Watanabe N, Tanoue Y, Omata M, Fujiwara K.
- Journal Title
  
  Biochem Biophys Res Commun 363
  
  Pages: 978-982
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, Inoue Y, Nishikawa T, Watanabe N, Ohtomo N, Omata M, Fujiwara K.
- Journal Title
  
  World J Gastroenterol 13
  
  Pages: 5071-5078
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats.2007
- Author(s)
  Ikeda H, Kume Y, Tejima K, Tomiya T, Nishikawa T, Watanabe N, Ohtomo N, Arai M, Arai C, Omata M, Fujiwara K, Yatomi Y.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 293
  
  Pages: 911-917
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats2007
- Author(s)
  Ikeda H, Kume Y, Tejima K, Tomiya T, Nishikawa T, Watanabe N, Ohtomo N, Arai M, Arai C, Omata M, Fujiwara K, Yatomi Y.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 293
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Oxygen radical production by NADPH oxidase in Kupffer cells promotes hepatic ischemic tolerance.2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T et al.
- Journal Title
  
  Hepatology International 1(1)
  
  Pages: 215-215
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590615
[Journal Article] Ischemic preconditioning in liver pathophysiology.2007
- Author(s)
  Arai M, Tejima K, Ikeda H, Tomiya T, et. al.
- Journal Title
  
  J Gastroenterol Hepatol 22(1)
  
  Pages: 65-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590749
[Journal Article] Stimulation by glutamine and proline of HGF production in hepatic stellate cells2007
- Author(s)
  Nishikawa T, Tomiya T, Ohtomo N, Inoue Y, Ikeda H, Tejima K, Watanabe N, Tanoue Y, Omata M, Fujiwara K.
- Journal Title
  
  Biochem Biophys Res Commun 363
  
  Pages: 978-982
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Effect of rapamycin on hepatocyte function and proliferation induced by growth factors2007
- Author(s)
  Tomiya T, Yamaoka M, Inoue Y, Nishikawa T, Yanase M, Ikeda H, Tejima K, Nagashima K, Watanabe N, Omata M, Fujiwara K.
- Journal Title
  
  Chemotherapy 53
  
  Pages: 59-69
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Effect of rapamycin on hepatocyte function and proliferation induced by growth factors.2007
- Author(s)
  Tomiya T, Yamaoka M, Inoue Y, Nishikawa T, Yanase M, Ikeda H, Tejima K, et al.
- Journal Title
  
  Chemotherapy 53・1
  
  Pages: 59-69
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Expression of transforming growth factor-alpha and -beta in hepatic lobes after hemihepatic portal vein embolization.2007
- Author(s)
  Kusaka K, Imamura H, Tomiya T, Takayama T, Makuuchi M.
- Journal Title
  
  Dig Dis Sci 51
  
  Pages: 1404-1412
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway.2007
- Author(s)
  Tomiya T, Nishikawa T, Inoue Y, Ohtomo N, Ikeda H, Tejima K, Watanabe N, Tanoue Y, Omata M. Fujiwara K
- Journal Title
  
  Biochem Biophys Res Commun 358
  
  Pages: 176-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Ischemic preconditioning in liver pathophysiology2007
- Author(s)
  Arai M, Tejima K, Ikeda H, Tomiya T, Yanase M, Inoue Y, Nagashima K, Nishikawa T, Watanabe N, Omata M, Fujiwara K.
- Journal Title
  
  J Gastroenterol Hepatol 22 : S1
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats2007
- Author(s)
  Kume Y, Ikeda H, Inoue M, Tejima K, Tomiya T, Nishikawa T, Watanabe N, Ichikawa T, Kaneko M, Okubo S, Yokota H, Omata M, Fujiwara K, Yatomi Y
- Journal Title
  
  FEBS Lett 581
  
  Pages: 1631-1634
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway2007
- Author(s)
  Tomiya T, Nishikawa T, Inoue Y, Ohtomo N, Ikeda H, Tejima K, et al.
- Journal Title
  
  Biochemical And Biophysical Research Communications (印刷中)
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats2007
- Author(s)
  Kume Y, Ikeda H, Inoue M, Tejima K, Tomiya T, Nishikawa T, Watanabe N, Ichikawa T, Kaneko M, Okubo S, Yokota H, Omata M, Fujiwara K, Yatomi Y.
- Journal Title
  
  FEBS Lett 581
  
  Pages: 1631-1634
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity2007
- Author(s)
  Watanabe N, Ikeda H, Nakamura K, Ohkawa R, Kume Y, Tomiya T, Tejima K, Nishikawa T, Arai M, Yanase M, Aoki J, Arai H, Omata M, Fujiwara K, Yatomi Y.
- Journal Title
  
  Life Sci 81
  
  Pages: 1009-1015
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Leucine stimulates HGF production by hepatic stellate cells through mTOR pathway.2007
- Author(s)
  Tomiya T, Nishikawa T, Inoue Y, Ohtomo N, Ikeda H, Tejima K, Watanabe N, Tanoue Y, Omata M, Fujiwara K.
- Journal Title
  
  Biochem Biophys Res Commun 358
  
  Pages: 176-180
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Oxygen radical production by NADPH oxidase in Kupffer cells promotes hepatic ischemic tolerance.2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, et al.
- Journal Title
  
  Hepatology International 1(1)
  
  Pages: 215-215
- Data Source
  KAKENHI-PROJECT-17590615
[Journal Article] Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats.2007
- Author(s)
  Kume Y, Ikeda H, Inoue M, Tejima K, Tomiya T, Nishikawa T, Watanabe N, et al.
- Journal Title
  
  FEBS Letters 58・18
  
  Pages: 1631-1634
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Plasma 1ysophosphatidic acid level and serum autotaxin activity are increased in in liver injury in rats in relation to its severity2007
- Author(s)
  Watanabe N, Ikeda H, Nakamura K, Ohkawa R, Kume Y, Tomiya T, Tejima K, Nishikawa T, Arai M, Yanase M, Aoki J, Arai H, Omata M Fujiwara K, Yatomi Y.
- Journal Title
  
  Life Sci 81
  
  Pages: 1009-1015
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Oxygen radical production by NADPH oxidase in Kupffer cells promotes hepatic ischemic tolerance.2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T et al.
- Journal Title
  
  Hepatology International 1 (1)
  
  Pages: 215-215
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590615
[Journal Article] Expression of trnsforming growth factor-alpha and -beta in hepatic lobes after hemihepatic portal vein embolization.2006
- Author(s)
  Kusaka K, H, Tomiya, T, Takayama, T, Makuuchi M
- Journal Title
  
  Digestive Diseases and Sciences 51・8
  
  Pages: 1404-1412
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] The herbal medicine inchin-ko-to (TJ-135) induces apoptosis in cultured rat hepatic stellate cells.2006
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, Arai M, Inoue Y, Tejima K, et al.
- Journal Title
  
  Life Sciences 78・19
  
  Pages: 2226-2233
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Hepatocyte preconditioning via activation of NADPH oxidase in Kupffer cells against warm ischemia/reperfusion injury.2005
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, et al.
- Journal Title
  
  Hepatology 42(4)
- Data Source
  KAKENHI-PROJECT-17590615
[Journal Article] Hepatocyte preconditioning via activation of NADPH oxidase in Kupffer cells against warm ischemia/reperfusion injury.2005
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M et al.
- Journal Title
  
  Hepatology 42(4)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590615
[Journal Article] Factors affecting liver regeneration after right portal vein embolization2004
- Author(s)
  Kusaka K, Imamura H, Tomiya T, Makuuchi M.
- Journal Title
  
  Hepatogastroenterology 51
  
  Pages: 532-535
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats.2004
- Author(s)
  Tajima K, Arai M, Ikeda H, Tomiya T, Yanase M, et al.
- Journal Title
  
  Gastroenterology 127
  
  Pages: 1488-1496
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation.2004
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, Arai M, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 320
  
  Pages: 754-759
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Factors affecting liver regeneration after right portal vein embolization.2004
- Author(s)
  Kusaka K, Imamura H, Tomiya T, Makuuchi M.
- Journal Title
  
  Hepatogastroenterology 51
  
  Pages: 532-535
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation.2004
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, Arai M, et al.
- Journal Title
  
  Biochem Biophys Res Commun 320
  
  Pages: 754-759
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Significance of branched chain amino acids as possible stimulators of hepatocvte growth factor.2004
- Author(s)
  Tomiya T, Omata M, Fujiwara K.
- Journal Title
  
  Biochem Biophys Res Commun 313
  
  Pages: 411-416
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Treatment with leucine stimulates the production of hepatocyte growth factor in vivo.2004
- Author(s)
  Tomiya T, Inoue Y, Yanase M, Arai M, Ikeda H et al.
- Journal Title
  
  Biochem Biophys Res Commun. 322
  
  Pages: 772-777
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Significance of branched chain amino acids as possible stimulators of hepatocyte growth factor.2004
- Author(s)
  Tomiya T, Omata M, Fujiwara K.
- Journal Title
  
  Biochem Biophys Res Commun 313
  
  Pages: 411-416
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats.2004
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, et al.
- Journal Title
  
  Gastroenterology 127
  
  Pages: 1488-1496
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] HMG-COA reductase inhibitor modulates collagen GEL-contraction by hepatic myofibroblast-like stellate cell line : involvement of geranylgeranylated proteins.2004
- Author(s)
  Yanase M, Ikeda H, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Comp Hepatol. 3
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Branched-chain amino acids, hepatocyte growth factor and protein production in the liver.2004
- Author(s)
  Tomiya T, Omata M, Fujiwara K.
- Journal Title
  
  Hepatol Res 30
  
  Pages: 14-18
- NAID
  10015455399
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] HMG-COA reductase inhibitor modulates collagen GEL-contraction by hepatic myofibroblast-like stellate cell line : involvement of geranylgeranylated proteins.2004
- Author(s)
  Yanase M, Ikeda H, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Comp Hepatol 3
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Significance of branched chain amino acids as possible stimulators of hepatocyte growth factor.2004
- Author(s)
  Tomiya T, Omata M, Fujiwara K.
- Journal Title
  
  Biochem Biophys Res Commun. 313
  
  Pages: 411-416
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Adenovirus-mediated overexpression of follistatin enlarges intact liver of adult rats.2003
- Author(s)
  Takabe K, Wang L, Leal AM, Macconell LA, Wiater E, Tomiya T, et al.
- Journal Title
  
  Hepatology 38
  
  Pages: 1107-1115
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells.2003
- Author(s)
  Skeda H, Nagashima K, Yanase M, Tomiya T, et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 285
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Functional Diversity between Rho-Kinase-and MLCK-Mediated Cytoskeletal Actions in a Myofibroblast-Like Hepatic Stellate Cell Line.2003
- Author(s)
  Yanase M, Ikeda H, Ogata I, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Biochem Biophys Res Commun 305
  
  Pages: 223-228
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Activation of Hepatic Macrophage Contributes to Hepatic Necrosis after Post-Ischemic Reperfusion in Alcoholic Fatty Liver.2003
- Author(s)
  Yamada S, Tomiya T, Yamaguchi Y, Hiura M, Otsuki M.
- Journal Title
  
  Hepatol Res 29
  
  Pages: 206-216
- NAID
  10016178338
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Functional Diversity between Rho-Kinase and MLCK-Mediated Cytoskeletal Actions in a Myofibroblast-Like Hepatic Stellate Cell Line.2003
- Author(s)
  Yanase M, Ikeda H, Ogata I, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 305
  
  Pages: 223-228
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Antiproliferative Property of Sphingosine 1-Phosphate in Rat Hepatocytes Involves Activation of Rho Via Edg-5.2003
- Author(s)
  Ikeda H, Satoh H, Yanase M, Inoue Y, Tomiya T, et al.
- Journal Title
  
  Gastroenterology 124
  
  Pages: 459-469
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells.2003
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 285
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Impaired liver regeneration in acute liver failure : the significance of cross-communication of growth associated actors in liver regeneration
- Author(s)
  Tomiya T, Omata M, Imamura H, Fujiwara K.
- Journal Title
  
  Hepatol Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Impaired liver regeneration in acute liver failure: the significance of cross-comm unication of growth associated factors in liver regeneration
- Author(s)
  Tomiya T, Omata M, Imamura H, Fujiwara K.
- Journal Title
  
  Hepatol Res
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] 肝星細胞コラーゲン産生に対するIGF-Iの調節作用およびその機序の検討2013
- Author(s)
  西川尚子, 富谷智明, 大友夏子, 井上有希子, 池田均, 白瀧博通, 小池和彦
- Organizer
  第17回日本肝臓学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] IGF-I reduces collagen production through induction of collagen degradation via mTOR dependent signaling pathway2013
- Author(s)
  西川尚子, 富谷智明, 大友夏子, 井上有希子, 池田均, 白瀧博通, 小池和彦
- Organizer
  第20回肝細胞研究会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] 肝星細胞におけるコラーゲン産生に対するIGF-Iの直接作用2012
- Author(s)
  西川尚子, 富谷智明, 大友夏子, 井上有希子, 池田均, 白瀧博通, 小池和彦
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Reduction of collagen production by insulin-like growth factor I is independent of activation state of hepatic stellate cells2012
- Author(s)
  Nishikawa T, Tomiya T, Ohtomo N, Inoue T, Ikeda H, Shirataki H, Koike K.
- Organizer
  The 63rd annual meeting of the American association for the study of liver diseases
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] 肝星細胞の増殖とコラーゲン産生に対するIGF-Iの影響に関する検討2012
- Author(s)
  西川尚子, 富谷智明, 大友夏子, 井上有希子, 池田均, 白瀧博通, 小池和彦
- Organizer
  第19回肝細胞研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Insulin-like growth factor I reduces collagen production by hepatic stellate cells even when their proliferative activity is stimulated2012
- Author(s)
  Nishikawa T, Tomiya T, Ohtomo N, Inoue Y, Ikeda H, Shirataki H, Koike K
- Organizer
  22nd Conference of the Asian Pacific Association for the Study of the Liver
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Insulin-like growth factor I reduces collagen production by hepatic stellate cells even when their proliferative activity is stimulated.2012
- Author(s)
  Nishikawa T, Tomiya T, Ohtomo N, Inoue Y, Ikeda H, Shirataki H, Koike K.
- Organizer
  22nd Conference of the Asian Pacific Association for the Study of the Liver
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] 肝星細胞の増殖とコラーゲン産生に対するIGF-I の影響に関する検討2012
- Author(s)
  西川尚子、富谷智明、大友夏子、井上有希子、池田均、白瀧博通、小池和彦
- Organizer
  第19回肝細胞研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Reduction of collagen production by Insulin-like growth factor I is independent of modulation of activation state in hepatic stellate cells2012
- Author(s)
  Nishikawa T, Tomiya T, Ohtomo N, Inoue Y, Ikeda H, Shirataki H, Koike K
- Organizer
  63rd Annual Meeting of the American Association for the Study of the Liver Diseases
- Place of Presentation
  Boston, Massachusetts
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] 血中ADAMTS13による肝細胞癌発症予測2011
- Author(s)
  池田均, 建石良介, 榎奥健一郎, 吉田晴彦, 中川勇人, 増崎亮太, 近藤祐爾, 五藤忠, 椎名秀一朗, 富谷智明, 井上有希子, 西川尚子, 大友夏子, 田上靖, 小池和彦
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Effect of IGF-I and mechanisms of its action on proliferation and protein production by rat hepatocytes2011
- Author(s)
  Tanoue Y, Tomiya T, Ohtomo N, Inoue Y, Nishikawa T, Ikeda H, Shirataki H, Koike K, Fujiwara K
- Organizer
  46th Annual Meeting of the European Association for the Study of the Liver
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Expression of alpha-taxilin correlates with growth activity and malignant potential of hepatocellular carcinoma2011
- Author(s)
  Ohtomo N, Shirataki H, Tomiya T
- Organizer
  16th World Congress on Advances in Oncology and 14th international Symposium on Molecular Medicine
- Place of Presentation
  Rhodes Island, Greece
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] 肝細胞に対するIGF-Iの作用点2011
- Author(s)
  田上靖, 富谷智明, 大友夏子, 西川尚子, 井上有希子, 池田均, 白瀧博通, 藤原研司, 小池和彦
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] 新たな肝線維化マーカーとしての血清Autotaxin抗原量2011
- Author(s)
  中川勇人, 池田均, 増崎亮太, 建石良介, 吉田晴彦, 渡邉尚子, 富谷智明, 井上有希子, 西川尚子, 大友夏子, 田上靖, 小池和彦
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Effect of IGF-I and mechanisms of its action on proliferation and protein production by rat hepatocytes.2011
- Author(s)
  Tanoue Y, Tomiya T, Ohtomo N, Inoue Y, Nishikawa T, Ikeda H, Shirataki H, Koike K, Fujiwara K.
- Organizer
  46th Annual Meeting of the European Association for the Study of the Liver
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Expression of alpha-taxilin correlates with growth activity and malignant potential of hepatocellular carcinoma.2011
- Author(s)
  Ohtomo N, Shirataki H, Tomiya T.
- Organizer
  16th World Congress on Advances in Oncology and 14th international Symposium on Molecular Medicine(招待講演)
- Place of Presentation
  Rhodes Island, Greece
- Data Source
  KAKENHI-PROJECT-23590961
[Presentation] Insulin-like growth factor I stimulates proliferation and protein production in rat hepatocytes through an mTOR signaling pathway.2010
- Author(s)
  Tanoue Y, Tomiya T, Ohtomo N, Nishikawa T, Inoue Y, Shirataki H, Ikeda H, Koike K, Fujiwara K
- Organizer
  Annual Meeting of the American Association for the Study of the Liver Diseases
- Place of Presentation
  Boston, Massachusetts
- Data Source
  KAKENHI-PROJECT-20590761
[Presentation] Insulin-like growth factor I stimulates proliferation and protein production in rat hepatocytes through an mTOR signaling pathway.2010
- Author(s)
  Tanoue Y, Tomiya T, et al.
- Organizer
  Annual meeting of the American association for the study of liver diseases
- Place of Presentation
  Boston, MA U.S.A
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-20590761
[Presentation] Direct effect of insulin-like growth factor I on proliferation and protein production by rat hepatocytes.2010
- Author(s)
  Tanoue Y, Tomiya T, Ohtomo N, Inoue Y, Nishikawa T, Ikeda H, Shirataki H, Koike K, Fujiwara K
- Organizer
  FASEB Summer Research Conference : Liver Growth, Injury and Metabolism, Basic and Applied Biology
- Place of Presentation
  Snowmass, Colorado, USA
- Data Source
  KAKENHI-PROJECT-20590761
[Presentation] Expression of alpha-taxilin may reflect malignant potential of hepatocellular carcinoma.2009
- Author(s)
  Ohtomo N, Tomiya T, Tanoue Y, Inoue Y, Nishikawa T, Watanabe N, Ikeda H, Koike K, Seyama Y, Kokudo N, Shibahara J, Shirataki H, Fujiwara K
- Organizer
  60 th Annual Meeting of the American Association for the Study of the Liver Diseases
- Place of Presentation
  Boston, Massachusetts
- Data Source
  KAKENHI-PROJECT-20590761
[Presentation] Expression of alpha-taxilin may reflect malignant potential of hepatocellular carcinoma.2009
- Author(s)
  Ohtomo N, Tomiya T, Tanoue Y, Inoue Y, Nishikawa T, et al.
- Organizer
  The 60^<th> annual meeting of the American association for the study of liver diseases
- Place of Presentation
  Boston, MA, USA
- Year and Date
  2009-11-03
- Data Source
  KAKENHI-PROJECT-20590761
[Presentation] Alpha-taxilin, a postulated vesicle traffic protein, may be involved in hepatocyte proliferation.2009
- Author(s)
  Ohtomo N, Tomiya T, Tanoue Y, Inoue Y, Nishikawa T, Watanabe N, Ikeda H, Omata M, Seyama Y, Kokudo N, Shibahara J, Fukayama M, Shirataki H, Fujiwara K
- Organizer
  44 th Annual Meeting of the European Association for the Study of the Liver
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-20590761
[Presentation] Alpha-taxilin,a novel syntaxin-binding protein, is involved in cell proliferation in rat liver2008
- Author(s)
  Ohtomo N, ToMiya T, Tanoue Y,. Inoue Y, Nishikawa T, Watanabe N, Ikeda H. et al.
- Organizer
  Faseb Summer Research Conference
- Place of Presentation
  Snowmass, Colorado, USA
- Year and Date
  2008-08-05
- Data Source
  KAKENHI-PROJECT-20590761
[Presentation] Alpha-taxillin, a novel syntaxin-binding protein, is involved in cell proliferation in rat liver.2008
- Author(s)
  Ohtomo N, Tomiya T, Tanoue Y, Inoue Y, Nishikawa T, Watanabe N, Ikeda H, Omata M, Shirataki H, Fujiwara K
- Organizer
  FASEB Summer Research Conference : Liver Biology, Development and Disease
- Place of Presentation
  Snowmass, Colorado, USA
- Data Source
  KAKENHI-PROJECT-20590761
[Presentation] Oxygen radical production by NADPH oxidase in Kupffer cells promotes ischemic tolerance2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Nishikawa T, Watanabe N, Ohtomo N, Yatomi Y, Omata M, Fujiwara K.
- Organizer
  The Asian Pacific Association for the Study of Liver Diseases
- Place of Presentation
  Kyoto, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Sublethal oxidative stress induces hepatic ischemic tolerance via NADPH oxidase in Kupffer cells2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Nishikawa T, Watanabe N, Ohtomo N, Yatomi Y, Omata M, Fujiwara K.
- Organizer
  Asian Pacific Digestive Week 2007
- Place of Presentation
  Kobe, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Serum follistatin levels as a marker of hepato-gastrointestinal carcinomas2007
- Author(s)
  Tomiya T, Takabe K, Inoue Y, Tejima K, Ikeda H, Nishikawa T, Watanabe N, Ohtomo N, Omata M, Vale W, Fujiwara K.
- Organizer
  Asian Pacific Digestive Week 2007
- Place of Presentation
  Kobe, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Inhibition of Rho-kinase leads to hepatocyte protection in vitro and in vivo2007
- Author(s)
  Ikeda H, Tomiya T, Tejima K, Nishikawa T, Watanabe N, Ohtomo N, Yatomi Y, Fujiwara K, Omata M.
- Organizer
  The Asian Pacific Association for the Study of Liver Diseases
- Place of Presentation
  Kyoto, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Chemotherapy-induced HB V reactivation in an HBV carrier showing negative for HBs Ag and HBs Ab2007
- Author(s)
  Ohtomo N, Tomiya T, Sakamoto K, Yoshida H, Kato N, Tejima K, Nishikawa T, Watanabe N, Ikeda H, Omata M.
- Organizer
  The Asian Pacific Association for the Study of Liver Diseases
- Place of Presentation
  Kyoto, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Sublethal oxidative stress induces hepatic ischemic tolerance via NADPH oxidase in Kupffer cells.2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, et. al.
- Organizer
  Asian Pacific Digestive Week (APDW)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19590749
[Presentation] Pharmacological action of BCAAs on the liver : Possible contribution of BCAAs to the function of hepatic stellate cells2007
- Author(s)
  Tomiya T, Nishikawa T, Ohtomo N, Inoue Y, Tejima K, Ikeda H, Watanabe N, Tanoue Y, Omate. M, Fujiwara K.
- Organizer
  Sixth JSH Single Topic Conference
- Place of Presentation
  Iwate, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Pharmacological action of BCAAs on the liver: Possible contribution of BCAAs to the function of hepatic stellate cells.2007
- Author(s)
  Tomiya T, Nishikawa T, Ohtomo N, moue Y, Tejima K, Ikeda H, Watanabe N, Tanoue Y, Omata M, fujiwara K.
- Organizer
  Sixth JSH Single Topic Conference
- Place of Presentation
  Iwate, Japan
- Year and Date
  2007-09-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Induction of p53-related effector genes may regulate hepatocyte proliferation stimulated by hepatocyte growth factor2007
- Author(s)
  Inoue Y, Tomiya T, Nishikawa T, Ohtomo N, Tanoue Y, Tejima K, Ikeda H, Watanabe N, Omata M, Fujiwara K.
- Organizer
  Asian Pacific Digestive Week 2007
- Place of Presentation
  Kobe, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Stimulatory effect of amino acids on HGF production in hepatic stellate cells2007
- Author(s)
  Nishikawa T, Tomiya T, Ohtomo N, Inoue Y, Tanoue Y, Tejima K, Ikeda H, Watanabe N, Omata M, Fujiwara K.
- Organizer
  Asian Pacific Digestive Week 2007
- Place of Presentation
  Kobe, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity2007
- Author(s)
  Watanabe N, Ikeda H, Tomiya T, Tejima K, Nishikawa T, Ohtomo N, Yatomi Y, Omta M, Fuiwara K.
- Organizer
  Asian Pacific Digestive Week 2007
- Place of Presentation
  Kobe, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Impaired liver regeneration in acute liver failure2007
- Author(s)
  Tomiya T, Omata M, Imamma H, Fujiwara K.
- Organizer
  Sixth JSH Single Topic Conference
- Place of Presentation
  Iwate, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Impaired liver regeneration in acute liver failure.2007
- Author(s)
  Tomiya T, Omata M, Imamura H, Fujiwara K.
- Organizer
  Sixth JSH Single Topic Conference
- Place of Presentation
  Iwate, Japan
- Year and Date
  2007-09-28
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Impaired Liver regeneration in acute liver failure2007
- Author(s)
  Tomiya T, Omata M, Imamura H, Fujiwara K.
- Organizer
  Sixth JSH Single Topic Conference
- Place of Presentation
  Iwate, Japan
- Year and Date
  2007-09-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] The relationship between serum follistatin levels and liver regeneration in hepatectomized patients2007
- Author(s)
  Tomiya T, Takabe K, Inoue Y, Tejima K, Ikeda H, Nishikawa T, Watanabe N, Ohtomo N, Omata M, Vale W, Fujiwara K.
- Organizer
  The Asian Pacific Association for the Study of Liver Diseases
- Place of Presentation
  Kyoto, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Expression of growth associated factors in regenerative and non-regenerative regions of the liver in patients with fulminant hepatic failure2006
- Author(s)
  Soeda J, Imamura ra H, Tomiya T, Hashikura Y, Kawasaki S, Fujiwara K, Miyagawa S.
- Organizer
  FASEB Summer Research Conference
- Place of Presentation
  Snowmess, Colorado, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Induction of P53-related effector genes may regulate hepatocyte proliferation stimulated by hepatocyte growth factor2006
- Author(s)
  Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Yanase M, Ikeda H, Tejima K, Omata M, Fujiwara K.
- Organizer
  FASEB Summer Research Conference
- Place of Presentation
  Snowmass, Colorado, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Induction of P53-related effector genes may regulate hepatocyte proliferation stimulated by hepatocyte growth factor2006
- Author(s)
  Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Yanase M, Ikeda H, Tejima K, Omata M, Fujiwara K.
- Organizer
  FASEB Summer Research Conference
- Place of Presentation
  Colorado, USA
- Year and Date
  2006-07-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590719

1. IKEDA Hitoshi (80202422)

# of Collaborated Projects: 18 results

# of Collaborated Products: 91 results
2. YANASE Mikio (50334397)

# of Collaborated Projects: 10 results

# of Collaborated Products: 25 results
3. ARAI Masahiro (60271566)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
4. TEJIMA Kazuaki (30396733)

# of Collaborated Projects: 5 results

# of Collaborated Products: 41 results
5. FUJIWARA Kenji (80101088)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. HIRATA Keiichi (50199064)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. MOCHIDA Sotoshi (20219968)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. OGATA Itsuro (80169169)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. OHNO Akihiko (30223902)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. NAGOSHI Sumiko

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. MASAKI Naohiko (40219316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YATOMI Yutaka (60200523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 中川勇人 (00555609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KINOSHITA Moritoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 下澤達雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 白瀧博通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 森屋恭爾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 小池和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 建石良介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TOMIYA Tomoaki 冨谷 智明

富谷 智明 トミヤ トモアキ

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Stimulation of liver regeneration and function by IGF-IPrincipal Investigator

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Induction of IGF-I production by amino acids in the liver : Its significance in the cirrhotic liverPrincipal Investigator

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Modulation by amino acids of the expression of factors produced by hepatic stellate cells : its implication in injured liverPrincipal Investigator

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Induction of hepatocyte growth factor by physiological agents : its effects on hepatocyte proliferation and protein productionPrincipal Investigator

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Significance of growth factors for Hepatocyte proliferation and functionsPrincipal Investigator

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TOMIYA Tomoaki 冨谷智明

富谷智明トミヤトモアキ