OHNO Takatoshi 大野貴敏

… Alternative Names

OONO Takatoshi 大野貴敏

大野貴敏オオノタカトシ

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Researcher Number	60281052
External Links
Affiliation (based on the past Project Information) *help	2016 – 2017: 岐阜大学, 大学院医学系研究科, 非常勤講師 2015: 岐阜大学, 医学(系)研究科(研究院), 非常勤講師 2012 – 2014: 岐阜大学, 医学(系)研究科(研究院), 准教授 2008: Gifu University, 大学院・医学研究科, 准教授 2008: 岐阜大学, 大学院・医学系・研究科, 准教授 … More 2007 – 2008: Gifu University, 大学院・医学系研究科, 准教授 2006: 岐阜大学, 大学院医学系研究科, 助教授 2005: 岐阜大学, 大学院・医学系研究科, 助教授 2004: 岐阜大学, 大学院・医学研究科, 助教授 2003: 岐阜大学, 医学部附属病院, 助手 1999: 岐阜大, 医学部, 助手 1998: 岐阜大学, 医学部, 助手 1996: GIFU UNIVERSITY SCHOOL OF MEDICINE,DEPARTMENT OF ORTHOPEDIC SURGERY,RESEARCH ASSOCIATE, 医学部, 助手 1996: 岐阜大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Orthopaedic surgery Except Principal Investigator Orthopaedic surgery
Keywords	Principal Investigator EWS / 遺伝子治療 / ユーイング肉腫 / リボザイム / キメラ遺伝子 / EWS/ATF1 / 明細胞肉腫 / 癌遺伝子 / アンチセンス / 転写因子 … More / EWS遺伝子 / ユ-イング肉腫 / 起源細胞 / iPS細胞 / CHIMERIC GENE / SIGNAL TRANSDUCTION / RIBOZYME / ANTISENSE / GENE THERAPY / EWS GENE / EWING'S SARCOMA / RNA結合蛋白 / アンチセンスセラピー / PKC / PLC / シグナル伝達 / 軟部肉腫 / トランスジェニックマウス / 分子標的治療 / Fos / EWS-ATF1 / 融合遺伝子 / 転写活性 / Flil遺伝子 / EWS-Flil融合遺伝子 / 骨軟部腫瘍 / オーロラキナーゼ / EWS-Fli1融合遺伝子 / 分化 / RNAi / FKHR / PAX3 / 横紋筋肉腫 / アンチセンスオリゴ / がん遺伝子 … More Except Principal Investigator 遺伝子 / 分子生物学 / ゲノム / マウスモデル / 癌 / 滑膜肉腫 / Fli1 / 貴伝子 / トランスジェニック / Flil / EWS / 骨軟部腫瘍 / ユーイング肉腫 Less

Identification of the cell-of-origin of clear cell sarcoma utilizing iPS cell technology and development of novel molecular therapyPrincipal Investigator
- Principal Investigator
  
  Ohno Takatoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Gifu University
EWS/ATF1 activates Fos and induces soft tissue sarcomas from neural crest-derived cellsPrincipal Investigator
- Principal Investigator
  
  OHNO Takatoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Gifu University
The study on the function of synovial sarcoma related SYT/SSX fusion gene against Aurora genes and its application for molecular targeting therapy
- Principal Investigator
  
  MASUDA Takahiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Gifu University
Analysis of Aurora Kinases in bone and soft tissue tumorsPrincipal Investigator
- Principal Investigator
  
  OONO Takatoshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Gifu University
ユーイング肉腫マウスモデルの樹立と解析
- Principal Investigator
  
  細江英夫
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Gifu University
RNAiによるユーイング肉腫、横紋筋肉腫のキメラ遺伝子を標的とした遺伝子治療Principal Investigator
- Principal Investigator
  
  大野貴敏
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Gifu University
小児悪性骨軟部腫瘍に対する遺伝子治療の基礎的研究Principal Investigator
- Principal Investigator
  
  大野貴敏
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Gifu University
ユ-イング肉腫に対する遺伝子治療の基礎的研究-キメラ遺伝子EWS/Fli-1,EWS/ergに対するアンチセンスオリゴDNA,およびリボザイムの抗腫瘍効果の検討-Principal Investigator
- Principal Investigator
  
  大野貴敏
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Gifu University
BASIC STUDY ON GENE THERAPY FOR EWING'S SARCOMA・・・BY INTRODUCING ANTISENSE EWS/FLI-1 GENE・・・Principal Investigator
- Principal Investigator
  
  OHNO Takatoshi, 松永隆信
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  DEPARTMENT OF ORTHOPAEDIC SURGERY,GIFU UNIVERSITY SCHOOL OF MEDICINE

All 2015 2014 2013 2012 2009 2008 2007 2005 Other

All Journal Article Presentation Book

[Book] 運動器診療　最新ガイドライン、　II．病態・疾患別のガイドライン、　骨腫瘍　Ewing 肉腫の診断・治療指針2012
- Author(s)
  大野貴敏
- Total Pages
  767
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-24592229
[Journal Article] EWS/ATF1 activates Fos and induces soft tissue sarcomas from neural crest-derived cells2013
- Author(s)
  Yamada K, Ohno T, Aoki H, Semi K, Watanabe A, Moritake H, Shiozawa S, Kunisada T, Kobayashi Y, Toguchida J, Shimizu K, Hara A, Yamada Y
- Journal Title
  
  J Clinical Investigation
  
  Volume: 123 Pages: 600-610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592229
[Journal Article] Ewing Sarcoma Cells Secrete EWS/Fli-1 Fusion mRNA via Microvesicles2013
- Author(s)
  Tsugita　M, Yamada N, Noguch S, Yamada K, Moritake H, Shimizu K, Akao Y, Ohno T
- Journal Title
  
  PLoS ONE
  
  Volume: 8 Pages: 1-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592229
[Journal Article] Growth Suppression and Mitotic Defect Induced by JNJ-7706621, an Inhibitor of　Cyclin-Dependent Kinases and Aurora Kinases.2012
- Author(s)
  Matsuhashi A, Ohno T, Kimura M, Hara A, Saio M, Nagano A, Kawai G, Saitou M, Takigami I, Yamada K, Okano Y, Shimizu K.
- Journal Title
  
  Curr Cancer Drug Targets
  
  Volume: 12 Issue: 6 Pages: 625-639
- DOI
  10.2174/156800912801784839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592229
[Journal Article] Simultaneous inhibition of mitogen-activated protein kinase and phosphatidylinost tol 3-kiiiase pathways augment the sensitivity to actinomycin D in Ewing sarcoma.2009
- Author(s)
  Yamamoto T, Ohno T, Wakahara K, et al.
- Journal Title
  
  J Cancer Res. Clin. Oncol. e-published ahead
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591628
[Journal Article] Simultaneous inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase actinomycin D in Ewing sarcoma2009
- Author(s)
  Yamamoto T, Ohno T, Wakahara K et.al.
- Journal Title
  
  J Cancer Res. Clin. Oncol.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591628
[Journal Article] EWS-Fli1 Up-Regulates Expression of the Aurora A and Aurora B Kinases Mol2008
- Author(s)
  Wakahara K., Ohno T. Kimura M. et.al.
- Journal Title
  
  Cancer Res 6
  
  Pages: 1937-1945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591628
[Journal Article] EWS-Flil Up-Regulates Expression of the Aurora A and Aurora B Kinases2008
- Author(s)
  Wakahara K., Ohno T. Kimura M., et al.
- Journal Title
  
  Mol. Cancer Res. 6
  
  Pages: 1937-1945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591628
[Journal Article] ユーイング肉腫の分化とEWS/Fli-1の発現2005
- Author(s)
  和田栄利里子, 大野貴敏, 野澤聡, 大島康司, 宝来慎吾, 伊東初美, 橋本敏彰, 加藤俊男, 清水克時
- Journal Title
  
  愛知県臨床衛生検査技師会誌らぼ 56巻1号
  
  Pages: 15-19
- Data Source
  KAKENHI-PROJECT-15659353
[Journal Article] Inhibition of Platelet-derived Growth Factor-induced Cell Growth Signaling by a short Interfering RNA for EWS-Fli1 via Down-regulation of Phospholipase D2 in Ewing sarcoma Cells.2005
- Author(s)
  Nozawa S, Ohno T, Banno Y, Dohjima T, Wakahara K, Fan DeGang, Shimizu K
- Journal Title
  
  The journal of Biological Chemistry Vol.280,No.30
  
  Pages: 27544-27551
- Data Source
  KAKENHI-PROJECT-15659353
[Journal Article] μCalpain is involved in the regulation of TNF-α-inducea matrix metalloproteinase-3 release in a rheumatoid synovial cell line.
- Author(s)
  Morita M, Banno Y, Dohjima T, Nozawa S, Fushimi K, Fan Degang, Ohno T, Miyamoto K, Liu N, Shimizu K
- Journal Title
  
  Biochemical and Biophysical Research Communications (In press)
- Data Source
  KAKENHI-PROJECT-15659353
[Presentation] EWS/ATF1誘導性肉腫細胞株由来iPS細胞を用いた発がん研究2015
- Author(s)
  河村真吾　秋山治彦　大野貴敏　山田一成　戸口田淳也　山田泰広
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山国際会議場
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-15K10437
[Presentation] 小児の骨軟部腫瘍2014
- Author(s)
  大野貴敏
- Organizer
  第12回東海小児整形外科研修会
- Place of Presentation
  名古屋
- Year and Date
  2014-12-21
- Invited
- Data Source
  KAKENHI-PROJECT-24592229
[Presentation] 軟部腫瘍の治療2012
- Author(s)
  大野貴敏
- Organizer
  第32回日整会骨軟部腫瘍特別研修会
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-24592229
[Presentation] EWS/ATF1の発現は軟部肉腫の発生を誘導する2012
- Author(s)
  山田一成、大野貴敏、永野昭仁、川井　豪、瀧上伊織、松橋　彩、齋藤　満、次田雅典、原　明、山田泰広、清水克時
- Organizer
  第45回日本整形外科学会骨軟部腫瘍学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592229
[Presentation] Simultaneous inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways augment the sensitivity to actinomycin D in Ewing sarcoma2009
- Author(s)
  Yamamoto T, Ohno T, Shimizu K et.al.
- Organizer
  55th Annual Meeting of the OrthopaedicResearch Society
- Place of Presentation
  Las Vegas, Nevada, USA
- Year and Date
  2009-02-23
- Data Source
  KAKENHI-PROJECT-18591628
[Presentation] Simultaneous inhibition of mitogen-activated protein kinase and phosphatidylinosi tol 3-kinase pathways augment the sensitivity to actinomycin D in Ewing sarcoma.2009
- Author(s)
  Yamamoto T, Ohno T, Shimizu K, et al.
- Organizer
  55th Annual Meeting of the Orthopaedic Research Society
- Place of Presentation
  Las Vegas, Nevada, USA
- Year and Date
  2009-02-23
- Data Source
  KAKENHI-PROJECT-18591628
[Presentation] Surgical outcome of giant cell tumor of bone2008
- Author(s)
  Ohno T, Oshima K, Shimizu K, et al.
- Organizer
  SICOT 24th Triennia1 World Congress
- Place of Presentation
  Hong Kong, China
- Year and Date
  2008-08-28
- Data Source
  KAKENHI-PROJECT-18591628
[Presentation] Surgical outcome of giant cell tumor of bone2008
- Author(s)
  Ohno T, Oshima K, Shimizu K et.al.
- Organizer
  SICOT 24th Triennial World Congress
- Place of Presentation
  Hong Kong, China
- Year and Date
  2008-08-28
- Data Source
  KAKENHI-PROJECT-18591628
[Presentation] EWS /Flil Fusion Gene Upregulate Aurora A Transcriptional Activity In Ewing's Tumor.2008
- Author(s)
  Wakahara K., Ohno T. Kimura M., et al.
- Organizer
  54th Annual Meeting of the Orthopaedic Research Society
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2008-03-04
- Data Source
  KAKENHI-PROJECT-18591628
[Presentation] EWS /Fli1 Fusion Gene Upregulate Aurora A Transcriptional Activity In Ewings Tumor2008
- Author(s)
  Wakahara K., Ohno T. Kimura M. et.al.
- Organizer
  54th Annual Meeting of the Orthopaedic Research Society
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2008-03-04
- Data Source
  KAKENHI-PROJECT-18591628
[Presentation] EWS融合遺伝子バイオロジーと臨床への展望2007
- Author(s)
  大野貴敏
- Organizer
  日本整形外科学会骨軟部腫瘍学術集会
- Place of Presentation
  甲府富士屋ホテル
- Year and Date
  2007-07-13
- Data Source
  KAKENHI-PROJECT-18591628
[Presentation] EWS/Fli1 fusion gene upregulate Aurora B transcriptional activity in Ewing's tumors2007
- Author(s)
  Wakahara K., Ohno T., Kimura K., Masuda T., Yamamoto T., Shimizu K.
- Organizer
  6th Combined Meeting of the Orthopaedic Research Societies
- Place of Presentation
  ハワイホノルルコンベンションセンター
- Year and Date
  2007-10-22
- Data Source
  KAKENHI-PROJECT-18591628
[Presentation] EWS/ATF1誘導性肉腫細胞株由来iPS細胞を用いたがん研究
- Author(s)
  河村真吾、大野貴敏、秋山治彦、山田一成、戸口田淳也、山田泰広
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24592229
[Presentation] Minimized surgery for patients with malignant bone tumor treated by continuous intra-arterial infusion chemotherapy
- Author(s)
  Takatoshi Ohno
- Organizer
  The 24th Japanese-Korean Combined Orthopaedic Symposium
- Place of Presentation
  Hakone, Japan
- Year and Date
  2014-06-05 – 2014-06-06
- Invited
- Data Source
  KAKENHI-PROJECT-24592229
[Presentation] EWS/ATF1誘導性肉腫細胞株由来iPS細胞作成の試み
- Author(s)
  河村真吾、大野貴敏、秋山治彦、山田泰広、戸口田淳也、山田一成
- Organizer
  第47回日本整形外科学会　骨・軟部腫瘍学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-07-17 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-24592229
[Presentation] EWS/ATF1はFosの転写を活性して細胞増殖に関与する
- Author(s)
  山田一成, 大野貴敏, 山田泰広, 原　明, 清水克時
- Organizer
  第46回日本整形外科学会骨軟部腫瘍学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592229
[Presentation] Ewing肉腫細胞は、融合遺伝子EWS/Fli-1のmRNAをmicrovesicle中に分泌している
- Author(s)
  次田雅典、山田名美、野口俊助、山田一成、盛武　浩、清水克時、赤尾幸博、大野貴敏、秋山治彦
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24592229

1. NISHIMOTO Yutaka (20208234)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. MASUDA Takahiro (20444250)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KIMURA Masashi (40260575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 細江英夫 (60219186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 松永隆信 (50021465)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 秋山治彦 (60402830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 永野昭仁 (60422721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Yamada Yasuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. Komura Shingo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

OHNO Takatoshi 大野 貴敏

OONO Takatoshi 大野 貴敏

大野 貴敏 オオノ タカトシ

Research Projects

Research Products

Co-Researchers

Identification of the cell-of-origin of clear cell sarcoma utilizing iPS cell technology and development of novel molecular therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

EWS/ATF1 activates Fos and induces soft tissue sarcomas from neural crest-derived cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study on the function of synovial sarcoma related SYT/SSX fusion gene against Aurora genes and its application for molecular targeting therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of Aurora Kinases in bone and soft tissue tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ユーイング肉腫マウスモデルの樹立と解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RNAiによるユーイング肉腫、横紋筋肉腫のキメラ遺伝子を標的とした遺伝子治療Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

小児悪性骨軟部腫瘍に対する遺伝子治療の基礎的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ユ-イング肉腫に対する遺伝子治療の基礎的研究-キメラ遺伝子EWS/Fli-1,EWS/ergに対するアンチセンスオリゴDNA,およびリボザイムの抗腫瘍効果の検討-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

BASIC STUDY ON GENE THERAPY FOR EWING'S SARCOMA・・・BY INTRODUCING ANTISENSE EWS/FLI-1 GENE・・・Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 運動器診療 最新ガイドライン、 II．病態・疾患別のガイドライン、 骨腫瘍 Ewing 肉腫の診断・治療指針2012

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] EWS/ATF1 activates Fos and induces soft tissue sarcomas from neural crest-derived cells2013

Author(s)

Journal Title

Data Source

[Journal Article] Ewing Sarcoma Cells Secrete EWS/Fli-1 Fusion mRNA via Microvesicles2013

Author(s)

Journal Title

Data Source

[Journal Article] Growth Suppression and Mitotic Defect Induced by JNJ-7706621, an Inhibitor of Cyclin-Dependent Kinases and Aurora Kinases.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simultaneous inhibition of mitogen-activated protein kinase and phosphatidylinost tol 3-kiiiase pathways augment the sensitivity to actinomycin D in Ewing sarcoma.2009

Author(s)

Journal Title

OHNO Takatoshi 大野貴敏

OONO Takatoshi 大野貴敏

大野貴敏オオノタカトシ

[Book] 運動器診療　最新ガイドライン、　II．病態・疾患別のガイドライン、　骨腫瘍　Ewing 肉腫の診断・治療指針2012

[Journal Article] Growth Suppression and Mitotic Defect Induced by JNJ-7706621, an Inhibitor of　Cyclin-Dependent Kinases and Aurora Kinases.2012