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Ishii Naoto  石井 直人

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ISHII Naoto  石井 直人

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Researcher Number 60291267
Other IDs
Affiliation (Current) 2025: 東北大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help 2016 – 2024: 東北大学, 医学系研究科, 教授
2017: 東北大学, 大学院医学系研究科, 教授
2012 – 2015: 東北大学, 医学(系)研究科(研究院), 教授
2014: 東北大学, 医学研究科(研究院), 教授
2014: 東北大学, 医学系研究科, 教授 … More
2014: 東北大学, 大学院医学系研究科, 教授
2009 – 2012: Tohoku University, 大学院・医学系研究科, 教授
2009 – 2011: 東北大学, 医学系研究科, 教授
2008: 東北大学, 医学系研究科, 准教授
2007 – 2008: Tohoku University, Tohoku University Graduate School of Medicine, Associate Professor
2007: Tohoku University, 大学院・医学研究科, 准教授
2005 – 2006: 東北大学, 大学院医学系研究科, 助教授
2003 – 2006: 東北大学, 大学院・医学系研究科, 助教授
1999 – 2002: Tohoku University, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手
2001: Tohoku University, School of Medicine, Research Associate, 医学系研究科, 助手
2001: 東北大学, 大学院・医学系研究所, 助手
1998: 東北大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Immunology / Experimental pathology / Basic Section 49070:Immunology-related / Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology / Immunology / Pediatrics
Except Principal Investigator
Immunology / Biological Sciences … More / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Virology / Immunology / Basic Section 50010:Tumor biology-related / Basic Section 49070:Immunology-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Epidemiology and preventive medicine / Morphological basic dentistry / Biological pharmacy / アレルギー / Metabolomics / Experimental pathology / Digestive surgery / Neurosurgery / Human genetics / Pediatrics / Circulatory organs internal medicine Less
Keywords
Principal Investigator
T細胞 / 炎症性腸疾患 / OX40リガンド / 制御性T細胞 / 記憶T細胞 / 間質性肺炎 / 免疫寛容 / 抗原提示細胞 / アレルギー / 免疫学 … More / CD4陽性T細胞 / 自己免疫疾患 / OX40リガンド(OX40L) / OX40L欠損マウス / 自然リンパ球 / 炎症 / サイトカイン / Th17細胞 / 免疫記憶 / T細胞補助シグナル / 疾患感受性遺伝子 / Leishmania major / 実験的自己免疫性脳脊髄炎 / 免疫応答 / 超硫黄 / 超硫黄分子 / T細胞共刺激分子 / アトピー性皮膚炎 / 腫瘍免疫 / 2型自然リンパ球 / GITR / 補助刺激シグナル / 腸管免疫 / リンパ節 / ヘルパーT細胞 / 腸管膜リンパ節 / ニッチ / Cytokine / T-cell costimulatory signal / CD4 T cells / Inflammatory response / 炎症反応 / T-cell costimulatory signals / regulatory T cells / Antigen presenting cell / CD4^+ T cell / Immunological tolerance / T細胞補助刺激 / Experimental autoimmune encephalomyelitis (EAE) / OX40L-deficient mice / OX40 ligand / OX40 / Leishmania Major感染症 / MLLキメラ遺伝子 / 白血病モデル / 動物モデル / ヒト化マウス / 白血病 / 腸管粘膜免疫 / Th17 / 恒常性維持 / 遺伝子導入マウス / 遺伝子欠損マウス / 癌細胞老化 / 細胞小胞輸送 / 神経変性疾患 / 脱ユビキチン化酵素 / タンパク質分解 / ユビキチン化タンパク質 / 遣伝子連鎖解析 / 遺伝子連鎖解析 / モデル動物 / HTLV-I / Foxp3 / 成人T細胞白血病 / 炎症性腸疾患モデルマウス / がん免疫 / OX40シグナル / CTLクロン / CTL活性 / 遺伝背景 / OX40L遺伝子導入マウス / 免疫制御 … More
Except Principal Investigator
サイトカイン / T細胞 / STAM / Jak3 / シグナル伝達 / 炎症 / STAM2 / OX40リガンド / IL-2 / SCID / γc鎖 / OX40 / TRAF / 自己免疫 / 免疫学 / 免疫 / OX40L / アポトーシス / Hgs / CD4 T細胞 / 自己免疫疾患 / 感染免疫 / 恒常性 / ILC2 / TNF / CD204 / SAP / SLE / 抗原提示細胞 / ウイルス / T細胞補助シグナル / 炎症反応 / Inflammatory bowel disease / 自己免疫病 / STAM1 / TCR / Grf40 / IL-2 receptor / IL-2受容体 / apoptosis / 慢性関節リウマチ / ヒト・パルボウイルス / 胎児水腫 / 遺伝子治療 / CD4陽性T細胞 / AMSH / IL-33 / 抗腫瘍免疫 / 2型自然リンパ球 / インターロイキン33 / 補助刺激シグナル / TNFR / リコンビナントタンパク質 / 免疫制御 / 補助刺激 / TNFリガンド / TNF受容体 / メモリー細胞 / 腫瘍免疫 / 自然免疫 / 造血 / 希少疾患 / ゲノム編集マウス / Bリンパ球 / 胎盤 / トランスミッション / 分子疫学 / 感染症 / トランスミッションダイナミクス / 伝播動態 / 疫学 / ザンビア / モンゴル / フィリピン / RSウイルス / 腸管免疫 / 舌下免疫 / 免疫寛容 / 粘膜免疫 / 自然リンパ球 / 補助刺激分子 / TNFRSF / ILC / NFκB / IL-9 / アレルギー性肺炎症 / アレルギー / GITR / Co-stimulatory molecule / Autoimmunity / 細胞補助シグナル / Macrophage scavenger receptor / dendritic cells / type 1 diabetes mellitus / スカベンジャー受容体 / NODマウス / 樹状細胞 / 1型糖尿病 / Platelet / Autoantibody / Adaptor molecule / Signal transduction / Animal disease model / Autoimmune disease / 血小板 / 自己抗体 / アダプター分子 / シグナル伝達分子 / 疾患モデル動物 / Inflammation / CD4 T cell / T cell costimulatory signal / vesicle trafficking / Cytokine / IL-7 / 制御性T細胞 / 蛋白分解 / 小胞輸送 / Hrs / STAMs / 抗原提示 / 細胞内小胞輸送 / Linkage analysis / OX40 (CD134) / Leishmania major / OX40L遺伝子導入マウス / OX40L遺伝子欠損マウス / OX40リガンド(OX40L) / 寄生虫 / 免疫記憶 / サイトメガロウイルス / L.major / エフェクターT細胞 / NK細胞 / OX40(CD134) / 遺伝子連鎖解析 / 炎症性腸疾患 / OX40 (CDI34) / Interstitial pneumonia / CD4^+ T cells / OX40L-transgenic mice / OX40L欠損マウス / 抗DNA抗体 / IBD / 間質性肺炎 / OX40L導入マウス / Graf40 / γc chain / G2 arrest / non-immune hydrops fetalis / NS1 / transgenic mice / Human parvovirus B19 / 細胞周期制御 / NS1非構造蛋白分子 / signal transduction / Grb2 family / Gads / Gbr2 / LAT / SLP76 / T細胞受容体情報伝達 / the γc chain / hydrops fetalis / rheumatoid arthritis / parvovirus / 非免疫性胎児水腫 / 伝染性紅斑 / 転写活性化因子 / リウマチ / パルボウイルス / 腸内細菌 / 塩化ナトリウム / 回腸嚢炎 / 大腸全摘 / CD40 / グリオーマ / 共刺激因子 / 免疫治療 / 脳腫瘍 / 腫瘍ワクチン / Th17 / TRAF5 / CD4+ T細胞 / ヘルパーT細胞 / 相同組換え / SCID-X1 / ゲノム編集 / CRISPR / 遺伝子修復 / アデノウイルスベクター / TALEN / iPS細胞 / 遺伝子ターゲッティング / 動物モデル / 先天性免疫不全症 / 挿入変異 / レトロウィルスベクター / セカンドヒット / k-ras / 白血病 / AF10 / MLL / LMO2 / レトロウイルスベクター / NOGマウス / 遺伝子 / 臨床 / 病理学 / 生体分子 / 遺伝学 / 低酸素 / 血管内皮 / 血管リモデリング / 骨髄置換 / 骨髄細胞 / 肺高血圧症 / ニッチ / 記憶T細胞 / 細胞外環境 / T細胞恒常性維持 / 胎生致死 / ノックアウトマウス Less
  • Research Projects

    (54 results)
  • Research Products

    (302 results)
  • Co-Researchers

    (80 People)
  •  Development of a method for activation of costimulatory immune receptors by using their corresponding multimerized ligands

    • Principal Investigator
      宗 孝紀
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 49:Pathology, infection/immunology, and related fields
    • Research Institution
      University of Toyama
  •  Regulation of T cell immune responses by supersulfidePrincipal Investigator

    • Principal Investigator
      石井 直人
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Tohoku University
  •  IL-33-ILC2系による抗腫瘍効果の作用機序の解明

    • Principal Investigator
      浅尾 敦子
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Tohoku University
  •  Developing a novel therapeutic strategy to infectious disease based on innate immune function of T lymphocytes

    • Principal Investigator
      Kawabe Takeshi
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 49:Pathology, infection/immunology, and related fields
    • Research Institution
      Tohoku University
  •  新たな自己反応性T細胞の恒常性維持機構ならびに生理的・病理的意義の解明

    • Principal Investigator
      河部 剛史
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Tohoku University
  •  Proof of a novel gene underlying B lymphocyte deficiency using genome-edited mice

    • Principal Investigator
      Kikuchi Atsuo
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Tohoku University
  •  Regulation of allergic and autoimmune responses by ILC2-T cell interactionPrincipal Investigator

    • Principal Investigator
      Ishii Naoto
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      Tohoku University
  •  Characterization of multifunctional roles of TRAF5 in pro-inflammatory cytokine receptor signaling

    • Principal Investigator
      SO Takanori
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      University of Toyama
  •  GITR signaling regulates ILC2 function

    • Principal Investigator
      Okuyama Yuko
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Roles for TNFR superfamily molecules in regulation of ILC functionPrincipal Investigator

    • Principal Investigator
      ISHII Naoto
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Tohoku University
  •  Transmission dynamics of Respiratory Syncytial Virus and Establishing New Control Measures

    • Principal Investigator
      Oshitani Hitoshi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Epidemiology and preventive medicine
    • Research Institution
      Tohoku University
  •  Regulation of inflammatory cytokine signaling by TRAF5

    • Principal Investigator
      SO TAKANORI
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      University of Toyama
      Tohoku University
  •  Identification and analysis of the niches for helper memory T cellsPrincipal Investigator

    • Principal Investigator
      ISHII Naoto
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Mechanism of sublingual immune tolerance induction by cross-talking with gut mucosal immunity

    • Principal Investigator
      SUGAWARA Shunji
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Tohoku University
  •  Pouchitis develops due to change of sodium concentration

    • Principal Investigator
      Kouhei Fukushima
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Tohoku University
  •  Development of novel immunotherapy against malignant glioma

    • Principal Investigator
      SAITO RYUTA
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurosurgery
    • Research Institution
      Tohoku University
  •  Roles of OX40 and IL-7 in homeostasis of memory T cellsPrincipal Investigator

    • Principal Investigator
      ISHII NAOTO
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Development of a highly efficient gene targeting strategy using adenovirus-mediated delivery of donor DNA and artificial nucleases

    • Principal Investigator
      MITANI Kohnosuke
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human genetics
    • Research Institution
      Saitama Medical University
  •  Roles of TRAF5 in the lineage commitment of helper T cell subsets

    • Principal Investigator
      SO Takanori
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Development of a novel human leukemia model using humanized micePrincipal Investigator

    • Principal Investigator
      ISHII Naoto
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Pediatrics
    • Research Institution
      Tohoku University
  •  T-cell costimulation-mediated regulation of mucosal inflammationPrincipal Investigator

    • Principal Investigator
      ISHII Naoto
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Tohoku University
  •  小胞輸送分子Hrsを介する細胞老化とがん細胞悪性形質の制御Principal Investigator

    • Principal Investigator
      石井 直人
    • Project Period (FY)
      2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Experimental pathology
    • Research Institution
      Tohoku University
  •  脱ユビキチン化酵素AMSH、AMSH-LPによるタンパク質分解機構の解明Principal Investigator

    • Principal Investigator
      石井 直人
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  Mechanisms and their regulation of autoimmune disorders

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      2007 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Leukemogenesis due to insertional mutagenesis-a NOG mouse model-

    • Principal Investigator
      TSUCHIYA Shigeru
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Tohoku University
  •  炎症性腸疾患感受性遺伝子の同定と機能解析Principal Investigator

    • Principal Investigator
      石井 直人
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  T細胞免疫記憶に関する細胞外環境の解析

    • Principal Investigator
      SUGAMURA Kazuo
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  肺高血圧症の分子機構における免疫系細胞活性化分子の役割の解明

    • Principal Investigator
      下川 宏明
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tohoku University
  •  Regulation of effector T cells that mediate inflammatory responsesPrincipal Investigator

    • Principal Investigator
      ISHII Naoto
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  成人T細胞白血病における白血病細胞起源に関する研究Principal Investigator

    • Principal Investigator
      石井 直人
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  CD4陽性記憶T細胞恒常性維持におけるOX40の役割Principal Investigator

    • Principal Investigator
      石井 直人
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  A unique CD204^+ subpopulation of dendritic cells in NOD mice

    • Principal Investigator
      TAKAHASHI Kazuma
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
  •  Development of therapy method target against OX40 signal for allergy or autoimmune diseases

    • Principal Investigator
      MURATA Kazuko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      アレルギー
    • Research Institution
      Tohoku University
  •  間質性肺炎および炎症性腸疾患責任遺伝子の同定Principal Investigator

    • Principal Investigator
      石井 直人
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  Functional and therapeutic study on inhibitory genes associated with collagen diseases

    • Principal Investigator
      ONO Masao
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Tohoku University
  •  間質性肺炎および炎症性腸疾患感受性遺伝子の同定Principal Investigator

    • Principal Investigator
      石井 直人
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  がん免疫における生体内免疫寛容制御機構の解明Principal Investigator

    • Principal Investigator
      石井 直人
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  T細胞補助刺激分子を介した調節性T細胞機能制御Principal Investigator

    • Principal Investigator
      石井 直人
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Immunological tolerance regulated by the interaction between T cell and antigen-presenting cellPrincipal Investigator

    • Principal Investigator
      ISHII Naoto
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Signal transducing pathways in immune cells and immunological disorders caused by their dysfunctions

    • Principal Investigator
      SUGAMURA Kazuo
    • Project Period (FY)
      2002 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  OX40-OX40リガンド系を介した免疫制御Principal Investigator

    • Principal Investigator
      石井 直人
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  アレルギー免疫疾患モデルマウスを用いた発症要因に関わる遺伝背景の解析Principal Investigator

    • Principal Investigator
      石井 直人
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  腫瘍免疫におけるOX40-OX40L系の機能解析Principal Investigator

    • Principal Investigator
      石井 直人
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  Regulation of infectious immunity by the OX40-0X4OL system

    • Principal Investigator
      SUGAMURA Kazuo
    • Project Period (FY)
      2001 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  新規シグナル分子"AMSH"の遺伝子欠損による脳神経特異的なアポトーシス誘導

    • Principal Investigator
      ASAO Hironobu
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tohoku University
  •  アレルギー免疫疾患モデルマウスを用いた発症要因に関わる遺伝背景の解析Principal Investigator

    • Principal Investigator
      石井 直人
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  Analysis of transgenic mice expressing human parvovirus non-stractual (NS1) protein

    • Principal Investigator
      SUGAMURA Kazuo
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Tohoku University
  •  Cytokine receptor γc chain/Jak3 mediated signal transduction and analysis of immunodeficiecy by dysfunction of the γc chain/Jak3

    • Principal Investigator
      TAKESHITA Toshikazu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Shinshu University
  •  Regulation of autoimmune diseases by OX40-OX40L interact

    • Principal Investigator
      SUGAMURA Kazuo
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Grf40, A Novel Grb2 Family Member, Is Involved in T Cell Signaling

    • Principal Investigator
      ASAO Hironobu
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  Immune regulation by OX40/OX40 ligand systemPrincipal Investigator

    • Principal Investigator
      ISHII Naoto
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University
  •  サイトカイン受容体を介する新たな増殖シグナル伝達経路“Jak-STAM"

    • Principal Investigator
      TAKESHITA Toshokazu
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tohoku University
  •  Establishment of Model Mice of Rheumatoid Arthritis by using nonstructural protein 1 (NS1) of parvovirus B19

    • Principal Investigator
      SUGAMURA Kazuo
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Tohoku University
  •  Cytokine receptor γc chain mediated signal transduction and analysis of immunodeficiency by dysfunction of the γc chain

    • Principal Investigator
      TAKESHITA Toshokazu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Tohoku University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 1999 1998 Other

All Journal Article Presentation Book Patent Other

  • [Book] Co-signal Molecules in T Cell Activation2019

    • Author(s)
      So Takanori、Ishii Naoto
    • Total Pages
      32
    • Publisher
      Springer
    • ISBN
      9789813297166
    • Data Source
      KAKENHI-PROJECT-18H02572
  • [Book] アレルギー2018

    • Author(s)
      石井直人,奥山祐子
    • Total Pages
      89
    • Publisher
      株式会社 杏林舎
    • ISBN
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Journal Article] <i>Staphylococcus aureus</i> skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis2022

    • Author(s)
      Terui Hitoshi、Yamasaki Kenshi、Wada-Irimada Moyuka、Onodera-Amagai Mayuko、Hatchome Naokazu、Mizuashi Masato、Yamashita Riu、Kawabe Takeshi、Ishii Naoto、Abe Takaaki、Asano Yoshihide、Aiba Setsuya
    • Journal Title

      Science Immunology

      Volume: 7 Issue: 76

    • DOI

      10.1126/sciimmunol.abm9811

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K08319, KAKENHI-PROJECT-22K19418, KAKENHI-PROJECT-20KK0362, KAKENHI-PROJECT-22H04956, KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-23K24146
  • [Journal Article] Phenotypic heterogeneity in individuals with MECOM variants in 2 families.2022

    • Author(s)
      Niihori T, Tanoshima R, Sasahara Y, Sato A, Irie M, Saito-Nanjo Y, Funayama R, Shirota M, Abe T, Okuyama Y, Ishii N, Nakayama K, Kure S, Imaizumi M, Aoki Y.
    • Journal Title

      Blood Adv.

      Volume: - Issue: 18 Pages: 5257-5261

    • DOI

      10.1182/bloodadvances.2020003812

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03637, KAKENHI-PROJECT-21H02458, KAKENHI-PROJECT-19K08855, KAKENHI-PROJECT-20K07546, KAKENHI-PROJECT-20K08766
  • [Journal Article] IL-33-ILC2 axis promotes anti-tumor CD8+ T cell responses via OX40 signaling2022

    • Author(s)
      Okuyama Y, Okajima A, Sakamoto N, Hashimoto A, Tanabe R, Kawajiri A, Kawabe T, Ishii N
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 637 Pages: 9-16

    • DOI

      10.1016/j.bbrc.2022.11.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19418, KAKENHI-PROJECT-20KK0362, KAKENHI-PROJECT-20K07546, KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-23K24146
  • [Journal Article] Redefining the Foreign Antigen and Self-Driven Memory CD4+ T-Cell Compartments via Transcriptomic, Phenotypic, and Functional Analyses2022

    • Author(s)
      Kawabe T, Ciucci T, Kim KS, Tayama S, Kawajiri A, Suzuki T, Tanaka R, Ishii N, Jankovic D, Zhu J, Sprent J, Bosselut R, Sher A
    • Journal Title

      Front Immunol

      Volume: 13 Pages: 870542-870542

    • DOI

      10.3389/fimmu.2022.870542

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19418, KAKENHI-PROJECT-20KK0362, KAKENHI-PROJECT-20J20344, KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-23K24146
  • [Journal Article] OX40 Ligand-Mannose-Binding Lectin Fusion Protein Induces Potent OX40 Cosignaling in CD4<sup>+</sup> T Cells2022

    • Author(s)
      Sato A, Azuma M, Nagai H, Imai W, Kawaguchi K, Morita M, Okuyama Y, Ishii N, So T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 45 Issue: 12 Pages: 1798-1804

    • DOI

      10.1248/bpb.b22-00493

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2022-12-01
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K07817, KAKENHI-PROJECT-20K07546, KAKENHI-PROJECT-20K08766
  • [Journal Article] Phenotypic heterogeneity in individuals with MECOM variants in 2 families.2022

    • Author(s)
      Niihori T, Tanoshima R, Sasahara Y, Sato A, Irie M, Saito-Nanjo Y, Funayama R, Shirota M, Abe T, Okuyama Y, Ishii N, Nakayama K, Kure S, Imaizumi M, Aoki Y
    • Journal Title

      Blood Adv

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K08766
  • [Journal Article] TNF Receptor-Associated Factor 5 Limits IL-27 Receptor Signaling in CD4 + T Lymphocytes2022

    • Author(s)
      Kawahara E, Azuma M, Nagashima H, Omori K, Akiyama S, Fujimori Y, Oishi M, Shibui N, Kawaguchi K, Morita M, Okuyama Y, Ishii N, So T.
    • Journal Title

      J Immunol.

      Volume: 208(3) Issue: 3 Pages: 642-650

    • DOI

      10.4049/jimmunol.2001358

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07546, KAKENHI-PROJECT-22K07817, KAKENHI-PROJECT-20K08766
  • [Journal Article] The Curcumin Analog GO-Y030 Controls the Generation and Stability of Regulatory T Cells2021

    • Author(s)
      Takashi MaruYama, Shuhei Kobayashi, Hiroko Nakatsukasa, Yuki Moritoki, Daiki Taguchi, Yoichi Sunagawa, Tatsuya Morimoto, Atsuko Asao, Wenwen Jin, Yuji Owada, Naoto Ishii, Yoshiharu Iwabuchi, Akihiko Yoshimura, WanJun Chen, Hiroyuki Shibata
    • Journal Title

      Frontiers in immunology

      Volume: 12 Pages: 687669-687669

    • DOI

      10.3389/fimmu.2021.687669

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07541, KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-20K11643
  • [Journal Article] Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing, and presentation2021

    • Author(s)
      Tashiro R, Niizuma K, Kasamatsu J, Okuyama Y, Rashad S, Kikuchi A, Fujimura M, Kure S, Ishii N, Tominaga T.
    • Journal Title

      J Cell Physiol.

      Volume: 236(11) Issue: 11 Pages: 7554-7564

    • DOI

      10.1002/jcp.30396

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07546, KAKENHI-PROJECT-20K08766
  • [Journal Article] Functional Analysis of the Transcriptional Regulator IκB-ζ in Intestinal Homeostasis2021

    • Author(s)
      Sasaki Tomoki、Nagashima Hiroyuki、Okuma Atsushi、Yamauchi Takeshi、Yamasaki Kenshi、Aiba Setsuya、So Takanori、Ishii Naoto、Owada Yuji、MaruYama Takashi、Kobayashi Shuhei
    • Journal Title

      Digestive Diseases and Sciences

      Volume: - Issue: 4 Pages: 1252-1259

    • DOI

      10.1007/s10620-021-06958-8

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02572, KAKENHI-PROJECT-20K08766
  • [Journal Article] Costello syndrome model mice with a HRAS G12S/+ mutation are susceptible to develop house dust mite-induced atopic dermatitis.2020

    • Author(s)
      Katata Y, Inoue S-I, Asao A, Kobayashi S, Terui H, Inoue-Shibui A, Abe T, Niihori T, Aiba S, Ishii N, Kure S, Aoki Y
    • Journal Title

      Cell Death & Disease

      Volume: 11 Issue: 8 Pages: 617-617

    • DOI

      10.1038/s41419-020-02845-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-20H03637, KAKENHI-PROJECT-18K19504
  • [Journal Article] GITR controls intestinal inflammation by suppressing IL-15-dependent NK cell activity.2020

    • Author(s)
      Sakurai T, Okuyama Y, Kobayashi S, Phung HT, Asao A, Kawabe T, Ndhlovu LC, Riccardi C, Kudo H, Wada M, Nio M, So T, Ishii N.
    • Journal Title

      FASEB J.

      Volume: 34(11) Issue: 11 Pages: 14820-14831

    • DOI

      10.1096/fj.202001675r

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07546, KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-20K16272, KAKENHI-PROJECT-18H02572
  • [Journal Article] TRAF5 promotes plasmacytoid dendritic cell development from bone marrow progenitors2020

    • Author(s)
      Kobayashi Shuhei、Shiota Yuka、Kawabe Takeshi、Phung Hai The、Maruyama Takashi、Owada Yuji、So Takanori、Ishii Naoto
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 521 Issue: 2 Pages: 353-359

    • DOI

      10.1016/j.bbrc.2019.10.123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02572, KAKENHI-PROJECT-17K00856
  • [Journal Article] Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.2020

    • Author(s)
      Kawabe T, Yi J, Kawajiri A, Hilligan K, Fang D, Ishii N, Yamane H, Zhu J, Jankovic D, Kim KS, Trinchieri G, Sher A
    • Journal Title

      Nat Commun

      Volume: 11 Issue: 1 Pages: 3366-3366

    • DOI

      10.1038/s41467-020-17136-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-20K16272
  • [Journal Article] Fatty acid-binding protein 5 limits ILC2-mediated allergic lung inflammation in a murine asthma model.2020

    • Author(s)
      Kobayashi S, Tayama S, Phung TH, Kagawa Y, Miyazaki H, Takahashi Y, Maruyama T, Ishii N, Owada Y
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 16617-16617

    • DOI

      10.1038/s41598-020-73935-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-20K11527, KAKENHI-PROJECT-20K11609, KAKENHI-PROJECT-20K19632, KAKENHI-PROJECT-20J20344, KAKENHI-PROJECT-19K24307
  • [Journal Article] TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells2020

    • Author(s)
      Phung Hai The、Nagashima Hiroyuki、Kobayashi Shuhei、Asano Naoki、Machiyama Tomoaki、Sakurai Tsuyoshi、Tayama Shun-ichi、Asao Atsuko、Imatani Akira、Kawabe Takeshi、Okuyama Yuko、Ishii Naoto、So Takanori
    • Journal Title

      ImmunoHorizons

      Volume: 4 Issue: 3 Pages: 129-139

    • DOI

      10.4049/immunohorizons.2000007

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02572, KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-20K16272
  • [Journal Article] Germ-free conditions modulate host purine metabolism, exacerbating adenine-induced kidney damage.2020

    • Author(s)
      Mishima E, Ishijo M, Kawabe T, Kikuchi K, Akiyama Y, Toyohara T, Suzuki C, Asao A, Ishii N, Fukuda S, Abe T
    • Journal Title

      Toxins

      Volume: 12 Issue: 9 Pages: 547-547

    • DOI

      10.3390/toxins12090547

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-20K16272, KAKENHI-PROJECT-18K08198, KAKENHI-PROJECT-18K08199, KAKENHI-PROJECT-19K23933, KAKENHI-PROJECT-19K23994
  • [Journal Article] IQGAP1 restrains T‐cell cosignaling mediated by OX402019

    • Author(s)
      Okuyama Yuko、Nagashima Hiroyuki、Ushio‐Fukai Masuko、Croft Michael、Ishii Naoto、So Takanori
    • Journal Title

      The FASEB Journal

      Volume: 34 Issue: 1 Pages: 540-554

    • DOI

      10.1096/fj.201900879rr

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02572, KAKENHI-PROJECT-17K08875
  • [Journal Article] GITR2019

    • Author(s)
      石井直人、奥山祐子
    • Journal Title

      アレルギー

      Volume: 68(3) Pages: 159-160

    • NAID

      130007650857

    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Journal Article] IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s2019

    • Author(s)
      Tayama Shunichi、Okuyama Yuko、Phung Hai The、Asao Atsuko、Kobayashi Shuhei、Musha Tomomi、Machiyama Tomoaki、Sakurai Tsuyoshi、Zhang Chengming、Ushio-Fukai Masuko、Kawabe Takeshi、So Takanori、Ishii Naoto
    • Journal Title

      International Immunology

      Volume: - Issue: 4 Pages: 233-241

    • DOI

      10.1093/intimm/dxz077

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02572, KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-20K16272
  • [Journal Article] TNF Receptor-Associated Factor 5 Limits Function of Plasmacytoid Dendritic Cells by Controlling IFN Regulatory Factor 5 Expression2019

    • Author(s)
      Kobayashi Shuhei、Sakurai Tsuyoshi、So Takanori、Shiota Yuka、Asao Atsuko、Phung Hai The、Tanaka Riou、Kawabe Takeshi、Maruyama Takashi、Kanno Emi、Kawakami Kazuyoshi、Owada Yuji、Ishii Naoto
    • Journal Title

      The Journal of Immunology

      Volume: 203 Issue: 6 Pages: 1447-1456

    • DOI

      10.4049/jimmunol.1900188

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02572, KAKENHI-PROJECT-17K00856
  • [Journal Article] The Role of Fatty Acid Binding Protein 7 in Spinal Cord Astrocytes in a Mouse Model of Experimental Autoimmune Encephalomyelitis2019

    • Author(s)
      Kamizato Kenyu、Sato Sho、Shil Subrata Kumar、Umaru Banlanjo A.、Kagawa Yoshiteru、Yamamoto Yui、Ogata Masaki、Yasumoto Yuki、Okuyama Yuko、Ishii Naoto、Owada Yuji、Miyazaki Hirofumi
    • Journal Title

      Neuroscience

      Volume: - Pages: 120-129

    • DOI

      10.1016/j.neuroscience.2019.03.050

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K00856, KAKENHI-PROJECT-19K05899, KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-19H04026
  • [Journal Article] Biallelic variants/mutations of IL1RAP in patients with steroid-sensitive nephrotic syndrome2019

    • Author(s)
      Niitsuma Sou、Kudo Hiroki、Kikuchi Atsuo、Hayashi Takaya、Kumakura Satoshi、Kobayashi Shuhei、Okuyama Yuko、Kumagai Naonori、Niihori Tetsuya、Aoki Yoko、So Takanori、Funayama Ryo、Nakayama Keiko、Shirota Matsuyuki、Kondo Shuji、Kagami Shoji、Tsukaguchi Hiroyasu、Iijima Kazumoto、Kure Shigeo、Ishii Naoto
    • Journal Title

      International Immunology

      Volume: 32 Issue: 4 Pages: 283-292

    • DOI

      10.1093/intimm/dxz081

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09719, KAKENHI-PUBLICLY-18H04795, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-18H02572, KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-18K19281, KAKENHI-PROJECT-19H03612, KAKENHI-PROJECT-18KK0244
  • [Journal Article] GITR cosignal in ILC2s controls allergic lung inflammation.2018

    • Author(s)
      Nagashima H, Okuyama Y, Fujita T, Takeda T, Motomura Y, Moro K, Hidaka T, Omori K, Sakurai T, Machiyama T, Ndhlovu LC, Riccardi C, So T, Ishii N.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: - Issue: 5 Pages: 1939-1943.e8

    • DOI

      10.1016/j.jaci.2018.01.028

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-15H04640, KAKENHI-PROJECT-15H04742, KAKENHI-PROJECT-16K15508, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-18H05286, KAKENHI-PROJECT-18H02572
  • [Journal Article] Concurrent Community Transmission of Enterovirus D68 with Human Rhinoviruses and Respiratory Syncytial Virus among Children in Sendai, Japan.2018

    • Author(s)
      Metoki T, Okamoto M, Suzuki A, Kitaoka S, Miyabayashi H, Rokugo Y, Onuma R, Noguchi R, Sato T, Watanabe Y, Ohmiya S, Sato K, Nishimura H, Oshitani H, Kumaki S.
    • Journal Title

      The Pediatric Infectious Disease Journal

      Volume: 37 Issue: 5 Pages: 394-400

    • DOI

      10.1097/inf.0000000000001768

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09080, KAKENHI-PROJECT-16H02642
  • [Journal Article] Regulation of Interleukin-6 Receptor Signaling by TNF Receptor-Associated Factor 2 and 5 During Differentiation of Inflammatory CD4+ T Cells2018

    • Author(s)
      Nagashima Hiroyuki、Ishii Naoto、So Takanori
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Pages: 1986-1986

    • DOI

      10.3389/fimmu.2018.01986

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02572
  • [Journal Article] TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK-JAK interaction.2018

    • Author(s)
      Kimura M, Nagashima H, Okuyama Y, Ishii N, and So T
    • Journal Title

      Int. Immunol

      Volume: - Issue: 7 Pages: 219-299

    • DOI

      10.1093/intimm/dxy029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04742, KAKENHI-PROJECT-16K15508, KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-18H02572
  • [Journal Article] TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation.2018

    • Author(s)
      Machiyama T, So T, Okuyama Y, Kobayashi S, Phung HT, Asao A, Harigae H, Ishii N.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: - Issue: 3 Pages: 544-550

    • DOI

      10.1016/j.bbrc.2018.03.186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-15H04742, KAKENHI-PROJECT-16K15508, KAKENHI-PROJECT-18H02572
  • [Journal Article] Bmi1 Regulates IκBα Degradation via Association with the SCF Complex.2018

    • Author(s)
      Okuyama Y, Tanaka Y, Jiang JJ, Kamimura D, Nakamura A, Ota M, Ohki T, Higo D, Ogura H, Ishii N, Atsumi T, Murakami M.
    • Journal Title

      J Immunol.

      Volume: 201(8) Issue: 8 Pages: 2264-2272

    • DOI

      10.4049/jimmunol.1701223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-17K19537
  • [Journal Article] CD103+ CD11b- salivary gland dendritic cells have antigen cross-presenting capacity.2017

    • Author(s)
      Lu L, Tanaka Y, Ishii N, Sasano T, Sugawara S
    • Journal Title

      Eur J Immunol

      Volume: 47 Issue: 2 Pages: 305-313

    • DOI

      10.1002/eji.201646631

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04742, KAKENHI-PROJECT-15H05011, KAKENHI-PROJECT-14J07005
  • [Journal Article] TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury2017

    • Author(s)
      Lan P, Fan Y, Zhao Y, Lou X, Monsour HP, Zhang X, Choi Y, Dou Y, Ishii N, Ghobrial RM, Xiao X, Li XC
    • Journal Title

      J Clin Invest.

      Volume: 127 Issue: 6 Pages: 2222-2234

    • DOI

      10.1172/jci91075

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04742, KAKENHI-PROJECT-16K15508
  • [Journal Article] Oral CD103-CD11b+ classical dendritic cells present sublingual antigen and induce Foxp3+ regulatory T cells in draining lymph nodes2017

    • Author(s)
      Tanaka Y, Nagashima H, Bando K, Lu L, Ozaki A, Morita Y, Fukumoto S, Ishii N, Sugawara S
    • Journal Title

      Mucosal Immunol

      Volume: 10 Issue: 1 Pages: 79-90

    • DOI

      10.1038/mi.2016.46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04742, KAKENHI-PROJECT-15H05011, KAKENHI-PROJECT-14J07005, KAKENHI-PROJECT-16K20638
  • [Journal Article] Inflammatory responses induce an identity crisis of alveolar macrophages, leading to pulmonary alveolar proteinosis.2017

    • Author(s)
      Ebina-Shibuya R, Matsumoto M, Kuwahara M, Jang KJ, Sugai M, Ito Y, Funayama R, Nakayama K, Sato Y, Ishii N, Okamura Y, Kinoshita K, Kometani K, Kurosaki T, Muto A, Ichinose M, Yamashita M, Igarashi K.
    • Journal Title

      The Journal of biological chemistry

      Volume: 292 Issue: 44 Pages: 18098-18112

    • DOI

      10.1074/jbc.m117.808535

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07108, KAKENHI-PROJECT-16K08572, KAKENHI-PROJECT-16K15232, KAKENHI-PROJECT-26221306, KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-15H04742, KAKENHI-PROJECT-16H05138, KAKENHI-PROJECT-16H05307, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-16H06640, KAKENHI-PROJECT-16K15289, KAKENHI-PROJECT-16K15508, KAKENHI-PROJECT-16K19158
  • [Journal Article] TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development2016

    • Author(s)
      Hiroyuki Nagashima, Yuko Okuyama, Takaya Hayashi, Naoto Ishii, Takanori So
    • Journal Title

      J. Immunol.

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H04640
  • [Journal Article] Local convection-enhanced delivery of an anti-CD40 agonistic monoclonal antibody induces antitumor effects in mouse glioma models.2016

    • Author(s)
      Shoji T, Saito R, Chonan M, Shibahara I, Sato A, Kanamori M, Sonoda Y, Kondo T, Ishii N, and Tominaga T
    • Journal Title

      Neuro-Oncology

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Journal Article] TNF receptor-associated factor-2 and -5 differentially regulate the instructive IL-6 receptor signaling that requires for Th17 development2016

    • Author(s)
      Nagashima H, Okuyama Y, Hayashi T, Ishii N, and So T
    • Journal Title

      J Immunol

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Journal Article] TIGIT marks exhausted T cells, correlates with disease progression, and serves as target for immune restoration in HIV and SIV infection2016

    • Author(s)
      Chew GM, Fujita T, Webb GM, Burwitz BJ, Wu HL, Reed JS, Hammond KB, Clayton KL, Ishii N, Abdel-Mohsen M, Liegler T, Mitchell BI, Hecht FM, Ostrowski M, Shikuma CM, Hansen SG, Maurer M, Korman AJ, Deeks SG, Sacha JB, Ndhlovu LC.
    • Journal Title

      PLoS Pathol

      Volume: 12 Issue: 1 Pages: e1005349-e1005349

    • DOI

      10.1371/journal.ppat.1005349

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Journal Article] OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia.2016

    • Author(s)
      Hirano T, Kikuchi T, Tode N, Santoso A, Yamada M, Mitsuhashi Y, Komatsu R, Kawabe T, Tanimoto T, Ishii N, Tanaka Y, Nishimura H, Nukiwa T, Watanabe A, Ichinose M.
    • Journal Title

      EMBO Mol Med.

      Volume: 8 Issue: 4 Pages: 422-436

    • DOI

      10.15252/emmm.201506154

    • NAID

      120006845618

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15316, KAKENHI-PROJECT-15H04742, KAKENHI-PROJECT-23390219, KAKENHI-PROJECT-16H05307
  • [Journal Article] Apurinic/apyrimidinic endonuclease 1/redox factor-1 (Ape1/Ref-1) modulates antigen presenting cell-mediated T helper cell type 1 responses2016

    • Author(s)
      Akhter N, Takeda Y, Nara H, Araki A, Ishii N, Asao N, Asao H
    • Journal Title

      J Biol Chem

      Volume: 291 Issue: 45 Pages: 23672-23680

    • DOI

      10.1074/jbc.m116.742353

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Journal Article] TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development2016

    • Author(s)
      Nagashima, H., Okuyama, Y., Hayashi, T., Ishii, N., So, T.
    • Journal Title

      J Immunol

      Volume: 196 Issue: 10 Pages: 4082-4089

    • DOI

      10.4049/jimmunol.1501610

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H04640, KAKENHI-PROJECT-15H04742, KAKENHI-PROJECT-16K15508
  • [Journal Article] Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the samall intestine in mice.2016

    • Author(s)
      Kawabe, T., Suzuki, N., Yamaki, S., Sun, S. L., Asao, A., Okuyama, Y., So, T., Iwakura, Y., and Ishii, N.
    • Journal Title

      Eur. J. Immunol.

      Volume: 46 Issue: 5 Pages: 1119-1131

    • DOI

      10.1002/eji.201545907

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-15H04640, KAKENHI-PROJECT-15H04742
  • [Journal Article] Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses.2016

    • Author(s)
      Furuse Y, Matsuzaki Y, Nishimura H, Oshitani H.
    • Journal Title

      Viruses

      Volume: 8 Issue: 12 Pages: 321-321

    • DOI

      10.3390/v8120321

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461563, KAKENHI-PROJECT-16H02642
  • [Journal Article] TRAF5を介したシグナル伝達2015

    • Author(s)
      宗 孝紀、石井 直人
    • Journal Title

      分子消化器病

      Volume: 12 Pages: 399-403

    • Data Source
      KAKENHI-PROJECT-15H04640
  • [Journal Article] OX40 ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: a clue for successful immunotherapy.2015

    • Author(s)
      Shibahara I, Saito R, Zhang R, Chonan M, Shoji T, Kanamori M, Sonoda Y, Kumabe T, Kanehira M, Kikuchi T, So T, Watanabe T, Takahashi H, Iwabuchi E, Tanaka Y, Shibahara Y, Sasano H, Ishii N, Tominaga T.
    • Journal Title

      Mol Cancer

      Volume: in press

    • NAID

      120006847260

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25670613
  • [Journal Article] OX40 ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: a clue for successful immunotherapy.2015

    • Author(s)
      Shibahara I, Saito R, Zahng R, Chonan M, Kanamori M, Sonoda Y, Kumabe T, Kanehira M, Kikuchi T, So T, Watanabe T, Takahashi H, Iwabuchi E, Tanaka Y, Shibahara Y, Sasano H, Ishii N, and Tominaga T
    • Journal Title

      Mol. Cancer

      Volume: 14 Pages: 41-53

    • NAID

      120006847260

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390118
  • [Journal Article] TNF Receptor-Associated Factor (TRAF) Signaling Network in CD4<sup>+</sup> T-Lymphocytes2015

    • Author(s)
      Takanori So, Hiroyuki Nagashima, Naoto Ishii
    • Journal Title

      Tohoku J. Exp. Med.

      Volume: 236 Issue: 2 Pages: 139-154

    • DOI

      10.1620/tjem.236.139

    • NAID

      130005075699

    • ISSN
      0040-8727, 1349-3329
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04640, KAKENHI-PROJECT-15H04742
  • [Journal Article] CD40/CD40L expression correlates with the survival of patients with glioblastomas and an augmentation in CD40 signaling enhances the efficacy of vaccinations and prolongs survival in intracranial glioma- and glioma-initiating cell-isografted tumor models2015

    • Author(s)
      Chonan M, Saito R, Shoji T, Shibahara I, Kanamori M, Sonoda Y, Watanabe M, Kikuchi T, Ishii N, and Tominaga T
    • Journal Title

      Neuro-Oncology

      Volume: 17 Issue: 11 Pages: 1453-1462

    • DOI

      10.1093/neuonc/nov090

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Journal Article] OX40 and IL-7 play synergistic roles in the homeostatic proliferation of effector memory CD4+ T cells.2014

    • Author(s)
      Yamaki S, Ine, S, Kawabe T, Okuyama Y, Suzuki N, Soroosh P, Mousavi SF, Nagashima H, Sun S-L, So T, Sasaki T, Harigae H, Sugamura K, Kudo H, Wada M, Nio M, and Ishii N.
    • Journal Title

      European Journal of Immunology

      Volume: 44 Issue: 10 Pages: 3015-3025

    • DOI

      10.1002/eji.201444701

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14J06157, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-25290047
  • [Journal Article] Fluorescently activated cell sorting followed by microarray profiling of helper T cell subtypes from human peripheral blood.2014

    • Author(s)
      Ono C, Yu Z, Kasahara Y, Kikuchi Y, Ishii N, Tomita H
    • Journal Title

      Plos One

      Volume: 9 Issue: 11 Pages: e111405-e111405

    • DOI

      10.1371/journal.pone.0111405

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-24116007, KAKENHI-PROJECT-24390118
  • [Journal Article] ヘルパーT細胞分化におけるTRAF5を介したチェックポイント制御2014

    • Author(s)
      宗孝紀、石井直人
    • Journal Title

      炎症と免疫

      Volume: 23 Pages: 21-26

    • Data Source
      KAKENHI-PROJECT-24590571
  • [Journal Article] Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques.2014

    • Author(s)
      Tsuyoshi Fujita, Benjamin J. Burwitz, Glen M. Chew, Jason S. Reed, Reesab Patahk, Elizabeth Seger, Kiera L. Clayton, James M. Rini, Mario A. Ostrowski, Naoto Ishii, Marcelo J. Kuroda, Scott G. Hansen, Jonah B. Sacha and Lishomwa C. Ndhlovu
    • Journal Title

      The Journal of Immunology

      Volume: 193 Issue: 11 Pages: 5576-83

    • DOI

      10.4049/jimmunol.1400961

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14J07575, KAKENHI-PROJECT-24390118
  • [Journal Article] OX40 ligand regulates splenic CD8- dendritic cell-induced Th2 responses in vivo.2014

    • Author(s)
      Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, Miyake S, Akiba H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 444 Issue: 2 Pages: 235-240

    • DOI

      10.1016/j.bbrc.2014.01.060

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J10815, KAKENHI-PROJECT-23390261, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24659487, KAKENHI-PROJECT-25461167, KAKENHI-PROJECT-25461503, KAKENHI-PROJECT-26293087
  • [Journal Article] TNF receptor-associated factor 5 limits inflammatory CD4+ T cell differentiation by antagonizing IL-6-receptor signaling.2014

    • Author(s)
      Nagashima H, Okuyama Y, Asao A, Kawabe T, Yamaki S, Nakano H, Croft M, Ishii N, and So T
    • Journal Title

      Nature Immunology

      Volume: 15 Issue: 5 Pages: 449-456

    • DOI

      10.1038/ni.2863

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-14J06157, KAKENHI-PROJECT-24390100, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24590571, KAKENHI-PROJECT-24659487, KAKENHI-PROJECT-25670167, KAKENHI-PLANNED-26110003
  • [Journal Article] Activation of Notch1 promotes development of human CD8+ single positive T cells in humanized mice2014

    • Author(s)
      Haji Y., Suzuki M, Moriya K, So T, Hozumi K, Mizuma M, Unno M, and Ishii N
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390118
  • [Journal Article] Hepatocyte Growth Factor Regulated Tyrosine Kinase Substrate in the peripheral development and function of B-cells2014

    • Author(s)
      Nagata T, Murata K, Murata R, Sun S-L, Saito Y, Yamaga S, Tanaka N, Tamai K, Moriya K, Kasai N, Sugamura K, and Ishii N.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 443 Issue: 2 Pages: 351-356

    • DOI

      10.1016/j.bbrc.2013.11.029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J06848, KAKENHI-PROJECT-23592521, KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-24592613, KAKENHI-PROJECT-24659487
  • [Journal Article] Activation of Notch1 promotes development of human CD8+ single positive T cells in humanized mice2014

    • Author(s)
      Haji Y, Suzuki M, Moriya K, So T, Hozumi K, Mizuma M, Unno M, and Ishii N
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659487
  • [Journal Article] Activation of Notch1 promotes development of human CD8+ single positive T cells in humanized mice.2014

    • Author(s)
      Haji Y, Suzuki M, Moriya K, So T, Hozumi K, Mizuma M, Unno M, and Ishii N.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 447 Issue: 2 Pages: 346-351

    • DOI

      10.1016/j.bbrc.2014.04.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24659487
  • [Journal Article] Homeostatic proliferation of naive CD4^+ T cells in mesenteric lymph no des generates gut-tropic Th17 cells.2013

    • Author(s)
      Takeshi Kawabe, et al
    • Journal Title

      J. Immunol.

      Volume: 190(印刷中) Issue: 11 Pages: 15788-5798

    • DOI

      10.4049/jimmunol.1203111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J06848, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24659487
  • [Journal Article] A smoll molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration.2013

    • Author(s)
      Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, Kiyomoto H, Ishii N, Okada K, Matsuo O, Hou FF, Vaughan DE, van Ypersele de Strihou S, Miyata T.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 33 Issue: 5 Pages: 935-942

    • DOI

      10.1161/atvbaha.113.301224

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590219, KAKENHI-PROJECT-23890019, KAKENHI-PROJECT-24249033, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24659487
  • [Journal Article] Gene therapy model of X-linked severe combined immunodeficiency using a modified foamy virus vector2013

    • Author(s)
      Horino S, Uchiyama T, So T, Nagashima H, Sun SL, Sato M, Asao A, Haji Y, Sasahara Y, Candotti F, Tsuchiya S, Kure S, Sugamura K, and Ishii N
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 8 Pages: e71594-e71594

    • DOI

      10.1371/journal.pone.0071594

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J06848, KAKENHI-PROJECT-24659486, KAKENHI-PROJECT-24659487, KAKENHI-PROJECT-25290047, KAKENHI-PROJECT-25860836
  • [Journal Article] Y-chromosome-linked B- and NK-cell deficiency in mice2013

    • Author(s)
      Sun SL, Horino S, Itoh-Nakadai A, Kawabe T, Asao A, Takahashi T, So T, Funayama R, Kondo M, Saitsu H, Matumoto N, Nakayama K, and Ishii N
    • Journal Title

      J. Immunol.

      Volume: 190 Issue: 12 Pages: 6209-6220

    • DOI

      10.4049/jimmunol.1300303

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J06848, KAKENHI-PLANNED-24118007, KAKENHI-PROJECT-24249019, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24390121, KAKENHI-PROJECT-24659487, KAKENHI-PROJECT-24700951
  • [Journal Article] A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese2012

    • Author(s)
      岡田随象
    • Journal Title

      PLoS Genetics

      Volume: (掲載確定) Issue: 1 Pages: 1002455-1002455

    • DOI

      10.1371/journal.pgen.1002455

    • NAID

      120005906866

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J00226, KAKENHI-PLANNED-19059005, KAKENHI-PROJECT-20689029, KAKENHI-PROJECT-21390299, KAKENHI-PROJECT-21591258, KAKENHI-PROJECT-21591277, KAKENHI-PLANNED-22021023, KAKENHI-PLANNED-22116010, KAKENHI-PROJECT-22591074, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23590379, KAKENHI-PROJECT-23689051, KAKENHI-PROJECT-24591436
  • [Journal Article] Development of a multi-step leukemogenesis model of MLL-rearranged leukemia using humanized mice2012

    • Author(s)
      Moriya K, Suzuki M, Watanabe Y, Takahashi T, Aoki Y, Uchiyama T, Kumaki S, Sasahara Y, Minegishi M, Kure S, Tsuchiya S, Sugamura K, and Ishii N.
    • Journal Title

      PLoS ONE

      Volume: 7(6) Issue: 6 Pages: e37892-e37892

    • DOI

      10.1371/journal.pone.0037892

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591150, KAKENHI-PROJECT-23659511, KAKENHI-PROJECT-23659512, KAKENHI-PROJECT-23791147, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24659487
  • [Journal Article] Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/γc^<null> mouse2012

    • Author(s)
      Suzuki M, Takahashi T, Katano I, Ito R, Ito M, Harigae H, Ishii N, Sugamura K.
    • Journal Title

      Int Immunol

      Volume: 24 Issue: 4 Pages: 243-52

    • DOI

      10.1093/intimm/dxs045

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005, KAKENHI-PROJECT-21390114, KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-22700458, KAKENHI-PROJECT-23590561, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24659487
  • [Journal Article] Runx1-deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells2012

    • Author(s)
      Wong WF, Kohu K, Nakamura A, Ebina M, Kikuchi T, Tazawa R, Tanaka K, Kon S, Funaki T, Sugahara-Tobinai A, Looi CY, Endo S, Funayama R, Kurokawa M, Habu S, Ishii N, Fukumoto M, Nakata K, Takai T, and Satake M.
    • Journal Title

      J. Immunol

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] Potential utility of eGFP-expressing NOG mice (NOG-EGFP) as a high purity cancer sampling system2012

    • Author(s)
      Shima K, et al
    • Journal Title

      J Exp Clin Cancer Res

      Volume: 31 Issue: 1 Pages: 55-61

    • DOI

      10.1186/1756-9966-31-55

    • URL

      http://www.jeccr.com/content/31/1/55

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390253, KAKENHI-PROJECT-23590452, KAKENHI-PROJECT-23791514, KAKENHI-PROJECT-23791515, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24659487
  • [Journal Article] Development of a multi-step leukemogenesis model of MLL-rearranged leukemia using humanized mice2012

    • Author(s)
      Moriya K, Suzuki M, Watanabe Y, Takahashi T, Aoki Y, Uchiyama T, Kumaki S, Sasahara Y, Minegishi M, Kure S, Tsuchiya S, Sugamura K, and Ishii N.
    • Journal Title

      PLoS ONE

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population2012

    • Author(s)
      Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K.
    • Journal Title

      Nat Genet.

      Volume: (in press) Issue: 5 Pages: 511-6

    • DOI

      10.1038/ng.2231

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005, KAKENHI-PROJECT-20689029, KAKENHI-PROJECT-21591264, KAKENHI-PLANNED-22133008, KAKENHI-PROJECT-22710191, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23689051, KAKENHI-PROJECT-24390360, KAKENHI-PROJECT-24591679, KAKENHI-PROJECT-24592285, KAKENHI-PROJECT-24659274, KAKENHI-PROJECT-221S0002, KAKENHI-PLANNED-22116010, KAKENHI-ORGANIZER-22133001
  • [Journal Article] nduction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/γcnull mouse2012

    • Author(s)
      Suzuki M, Takahashi T, Katano I, Ito R, Ito M, Harigae H, Ishii N, and Sugamura K.
    • Journal Title

      Int. Immunol

      Volume: 24 Pages: 243-252

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells.2012

    • Author(s)
      Wong WF, Tazawa R, (15名略)Nakata K, Takai T, Satake M.
    • Journal Title

      J Immunol.

      Volume: 188(11) Issue: 11 Pages: 5408-5420

    • DOI

      10.4049/jimmunol.1102991

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22242001, KAKENHI-PROJECT-22590431, KAKENHI-PROJECT-22590852, KAKENHI-PROJECT-23390219, KAKENHI-PROJECT-23659498, KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24330219, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24659174, KAKENHI-PROJECT-24659215, KAKENHI-PROJECT-24659487
  • [Journal Article] A genome-wide association study identifies RNF213 as the first Moyamoya disease gene2011

    • Author(s)
      Kamada, F., Aoki, Y., Narisawa, A., Abe, Y., Komatsuzaki, S., Kikuchi, A., Kanno, J., Niihori, T., Ono, M., Ishii, N., Owada, Y., Fujimura, M., Mashimo, Y., Suzuki, Y., Hata, A., Tsuchiya, S, Tominaga, T., Matsubara, Y, and Kure, S.
    • Journal Title

      J. Hum. Genet

      Volume: 56 Pages: 34-40

    • NAID

      10030657293

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] Interaction between NK cells and dendritic cells generate MHC class II-dressed NK cells to regulate CD4^+ T cells2011

    • Author(s)
      Nakayama M, Takeda K, Kawano M, Takai T, Ishii N, Ogasawara K
    • Journal Title

      Proc.Natl.Acad.Sci.USA

      Volume: 108 Pages: 18360-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] Interaction between NK cells and dendritic cells generate MHC class II-dressed NK cells to regulate CD4+ T cells2011

    • Author(s)
      Nakayama M, Takeda K, Kawano M, Takai T, Ishii N, and Ogasawara K.
    • Journal Title

      Proc Natl. Acad. Sci. USA

      Volume: 108 Pages: 18360-5

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension2011

    • Author(s)
      Rabieyousefi M, Soroosh P, Satoh K, Date F, Ishii N, Yamashita M, Oka M,McMurtry IF, Shimokawa H, Nose M, Sugamura K, Ono M.
    • Journal Title

      Immunol

      Volume: 12 Issue: 1 Pages: 67-67

    • DOI

      10.1186/1471-2172-12-67

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005, KAKENHI-PROJECT-21221004, KAKENHI-PROJECT-21390114, KAKENHI-PROJECT-23659408
  • [Journal Article] Interaction between NK cells and dendritic cells generate MHC class II-dressed NK cells to regulate CD4^+ T cells2011

    • Author(s)
      Nakayama M, Takeda K, Kawano M, Takai T, Ishii N, Ogasawara K.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 108 Pages: 18360-5

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22042851

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] Involvement of osteopontin and its signaling molecule CD44 in clinicopathological features of adult T cell leukemia2011

    • Author(s)
      Chagan-Yasutan H, Tsukasaki K, Takahashi Y, Oguma S, Harigae H, Ishii N, Zhang J, Fukumoto M, Hattori T.
    • Journal Title

      Leuk Res.

      Volume: 35 Issue: 11 Pages: 1484-90

    • DOI

      10.1016/j.leukres.2011.05.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005, KAKENHI-PROJECT-21390114
  • [Journal Article] ndispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension2011

    • Author(s)
      Rabieyousefi M, Soroosh P, Satoh K, Date F, Ishii N, Yamashita M, Oka M, McMurtry IF, Shimokawa H, Nose M, Sugamura K, and Ono M.
    • Journal Title

      BMC Immunol

      Volume: 12 Pages: 67-67

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] Involvement of osteopontin and its signaling molecule CD44 in clinicopathological features of adult T cell leukemia2011

    • Author(s)
      Chagan-Yasutan H, Tsukasaki K, Takahashi Y, Oguma S, Harigae H, Ishii N, Zhang J, Fukumoto M, and Hattori T.
    • Journal Title

      Leuk Res

      Volume: 35 Pages: 1484-90

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] OX40-OX40L ligand interaction in T cell-mediated immunity and immunopathology2010

    • Author(s)
      Ishii, N., Takahashi, T., Soroosh, P., and Sugamura, K.
    • Journal Title

      Adv. Immunol

      Volume: 105 Pages: 63-98

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] OX40 ligand plays an important role in the development of atherosclerosis through vasa vasorum neovascularizatio2010

    • Author(s)
      Nakano, M., Fukumoto, Y., Satoh, K., Ito, Y., Kagaya, Y., Ishii N., Sugamura, K., and Shimokawa, H.
    • Journal Title

      Cardiovasc. Res

      Volume: 88 Pages: 539-546

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] OX40-OX40L interaction in T cell-mediated immunity and immunopathology2010

    • Author(s)
      Ishii N, et al
    • Journal Title

      Adv.Immunol.

      Volume: 105 Pages: 63-98

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] Early production of tumor necrosis factor-alpha by Gr-1(+)cells and its role in the host defense to pneumococcal infection in lungs2010

    • Author(s)
      Hatta, M., Yamamoto, N., Miyazato, A., Ishii, N., Nakamura, K., Inden, K., Aoyagi, T., Kunishima, H., Hirakata, Y., Suzuki, K., Kaku, M., and Kawakami, K.
    • Journal Title

      FEMS Immunol & Medical Microbiol

      Volume: 58 Pages: 182-192

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] Characterization of the EpCAM+ cell population in hepatocellular carcinoma cell lines2010

    • Author(s)
      Kimura, O., Takahashi, T., Ishii N, Inoue, Y., Ueno, Y., Kogure, T., Fukushima, K., Shiina, M., Yamagiwa, Y., Kondo, Y., Inoue, J., Kakazu, E., Iwasaki, T., Kawagishi, N., Shimosegawa, T., and Sugamura, K
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 2145-2155

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] Serial OX40 engagement on CD4+ T cells and NKT cells causes allergic airway inflammation2010

    • Author(s)
      Damayanti T, Kikuchi T, Zaini J, Daito H, Kanehira M, Kohu K, Ishii N, Satake M, Sugamura K, and Nukiwa T.
    • Journal Title

      Am. J. Respir. Crit. Care. Med

      Volume: 181 Pages: 688-698

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] OX40-OX40L ligand interaction in T cell-mediated immunity and immunopathology2010

    • Author(s)
      Naoto Ishii
    • Journal Title

      Adv.Immunol. 105(印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] OX40 ligand plays an important role in the development of atherosclerosis through vasa vasorum neovascularization2010

    • Author(s)
      Nakano M, Fukumoto Y, Satoh K, Ito Y, Kagaya Y, Ishii N, Sugamura K, Shimokawa H.
    • Journal Title

      Cardiovasc Res.

      Volume: 88 Issue: 3 Pages: 539-46

    • DOI

      10.1093/cvr/cvq211

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005, KAKENHI-PROJECT-22590800
  • [Journal Article] Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice2010

    • Author(s)
      Shima, T., Sasaki, Y., Itoh, M., Nakashima, A., Ishii N., Sugamura, K., and Saito, S.
    • Journal Title

      J. Reprod. Immunol

      Volume: 85 Pages: 121-129

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] Serial OX40 engagement on CD4+ T cells and natural killer T cells causes allergic airway inflammation2010

    • Author(s)
      Damayanti T, Kikuchi T, Zaini J, Daito H, Kanehira M, Kohu K, Ishii N, Satake M, Sugamura K, Nukiwa T.
    • Journal Title

      Am J Respir Crit Care Med.

      Volume: 181 Issue: 7 Pages: 688-98

    • DOI

      10.1164/rccm.200910-1598oc

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] In vivo assay of human NK-dependent ADCC using NOD/SCID/γcnull (NOG)mice2010

    • Author(s)
      Shiokawa, M., Takahashi, T., Murakami, A., Kita, S, Ito, M., Sugamura, K., and Ishii, N.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 399 Pages: 733-737

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] The analysis of the functions of human B and T cells in humanized NOD/shi-scid/γcnull (NOG)mice (hu-HSC NOG mice)2009

    • Author(s)
      Watanabe, Y., Takahashi, T., Okajima, A., Shiokawa, M., Ishii, N., Katano, I., Ito, R., Ito, M., Minegishi, M., Minegishi, N., Tsuchiya, S., and Sugamura, K.
    • Journal Title

      Int. Immunol

      Volume: 21 Pages: 843-858

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome2009

    • Author(s)
      Minegishi Y, Saito M, Nagasawa M, Takada H, Hara T, Tsuchiva S, Agematsu K, Yamada M, Kawamura N, Ariga T, Tsuge I, Karasuyama H.
    • Journal Title

      J Exp Med. 206(6)

      Pages: 1291-301

    • Data Source
      KAKENHI-PROJECT-19390280
  • [Journal Article] Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-12009

    • Author(s)
      Satoh, K., Fukumoto, Y., Nakano, M., Sugimura, K., Nawata, J., Demachi, J., Karibe, A., Kagaya, Y., Ishii, N., Sugamura, K., and Shimokawa, H.
    • Journal Title

      Cardiovasc. Res

      Volume: 81 Pages: 226-34

    • Data Source
      KAKENHI-PROJECT-21390114
  • [Journal Article] Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia2009

    • Author(s)
      Horino S, Rikiishi T, Niizuma H, Abe H, Watanabe Y, Onuma M, Hoshi Y, Sasaharn Y, Yoshinari M, Kazama T, Hayashi Y, Kumaki S, Tsuchiva S.
    • Journal Title

      Int J Hematol. 90(4)

      Pages: 483-5

    • NAID

      10026109509

    • Data Source
      KAKENHI-PROJECT-19390280
  • [Journal Article] The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice)2009

    • Author(s)
      Watanabe Y, Takahashi T, Okajima A, Shiokawa M, Ishii N, Katano I, Ito R, Ito M, Minegishi M, Minegishi N, Tsuchiva S, Sugamura K.
    • Journal Title

      Int Imunol. 21(7)

      Pages: 843-58

    • Data Source
      KAKENHI-PROJECT-19390280
  • [Journal Article] OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells2008

    • Author(s)
      Mousavi SF, Soroosh P, Takahashi T, Yoshikai Y, Shen H, Lefrancois L, Borst J, Sugamura K, Ishii N.
    • Journal Title

      J Immunol.

      Volume: 181 Pages: 5990-6001

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/18941188

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome2007

    • Author(s)
      Minegishi, et. al.
    • Journal Title

      Nature 448

      Pages: 1058-1062

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390280
  • [Journal Article] Hepatocyte growth factor significantly suppresses collagen-induced Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice arthritis in mice.2007

    • Author(s)
      Okunishi K, Dohi M, Fujio K, Nakagome K, Yamamoto K, 他7名
    • Journal Title

      J Immunol. 179

      Pages: 5504-5513

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome2007

    • Author(s)
      Minegishi Y, Saito M, Tsuchiya S, Tsuge I, Takada H, Hara T, Kawamura N, Ariga T, Pasic S, Stojkovic O, Metin A, Karasuyama H.
    • Journal Title

      Nature 448(7147)

      Pages: 1058-62

    • Data Source
      KAKENHI-PROJECT-19390280
  • [Journal Article] Efficient and controlled gene expression in mouse pancreatic islets by arterial delivery of tetracycline-inducible adenoviral vectors.2007

    • Author(s)
      Takahashi R, Ishihara H, Takahashi K, Tamura A, Yamaguchi S, Yamada T, Katagiri H, Oka Y.
    • Journal Title

      J Mol Endocrinol. 38(1):

    • Data Source
      KAKENHI-PROJECT-17590911
  • [Journal Article] OX40-OX40 Ligand Interaction through T Cell- T Cell Contact Contributes to CD4 T Cell Longevity2006

    • Author(s)
      Pejman Soroosh, Shouji Ine, Kazuo Sugamura, Naoto Ishii
    • Journal Title

      The Journal of Immunology 176

      Pages: 5975-5987

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17607001
  • [Journal Article] Phage phiC31 integrase-mediated genomic integration of the common cytokine receptor gamma chain in human T-cell lines2006

    • Author(s)
      Yoshinori Ishikawa et al.
    • Journal Title

      J Gene Med.. 8

      Pages: 646-653

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14104011
  • [Journal Article] OX40-OX40 Ligand Interaction through T Cell-T Cell Contact Contributes to CD4 T Cell Longevity2006

    • Author(s)
      Pejman Soroosh, Shouji Ine, Kazuo Sugamura, Naoto Ishii
    • Journal Title

      The Journal of Immunology 176

      Pages: 5975-5987

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17607001
  • [Journal Article] Phage phiC31 integrase-mediated genomic integration of the common cytokine receptor gamma chain in human T-cell lines.2006

    • Author(s)
      Yoshinori Ishikawa
    • Journal Title

      J Gene Med. 8

      Pages: 646-653

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14104011
  • [Journal Article] A signal adaptor SLAM-Associated Protein regulates spontaneous autoimmunity and Fas- dependent lymphoproliferation in MRL-Fas^<lpr> lupus mice.2006

    • Author(s)
      Komori H, Furukawa H, Mori S, Ito MR, Terada M, Zhang MC, Ishii N, Sakuma N, Nose M, Ono M.
    • Journal Title

      J Immunol 176

      Pages: 395-400

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390113
  • [Journal Article] Hrs, a mammalian master molecule in vesicular transport and protein-sorting, suppresses the degradation of ESCRT proteins STAM1 and STAM2.2005

    • Author(s)
      Kobayashi, H., Ishii, N.ほか
    • Journal Title

      J.Biol.Chem. 280

      Pages: 10468-10477

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] During Viral Infection of the Respiratory Tract, CD27, 4-1BB, and OX40 Collectively Determine Formation of CD8^+ Memory T Cells and Their Capacity for Secondary Expansion2005

    • Author(s)
      Jenny Hendriks, Yanling Xiao, John W.A.Rossen, Koenraad F.van der Sluijs, Kazuo Sugamura, Naoto Ishii, Jannie Borst
    • Journal Title

      The Journal of Immunology 175

      Pages: 1665-1676

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17607001
  • [Journal Article] Positional identification of TNFSF4,encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility.2005

    • Author(s)
      Wang, X., Ishii, N., Sugamura, K.ほか
    • Journal Title

      Nat.Genet (印刷中)

    • Data Source
      KAKENHI-PROJECT-13226006
  • [Journal Article] Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility.2005

    • Author(s)
      Wang, X., Ishii, N.ほか
    • Journal Title

      Nat.Genet 37

      Pages: 365-372

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Positional identification of TNFSF4,encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility.2005

    • Author(s)
      Wang, X., Ishii, N.ほか
    • Journal Title

      Nat. Genet (印刷中)

    • Data Source
      KAKENHI-PROJECT-16012205
  • [Journal Article] Hypoglycemic effects of turmeric(Curcuma longa L. rhizomes)on genetically diabetic KK-Ay mice2005

    • Author(s)
      Kuroda M, Mimaki Y, Nishiyama T, Mae T, Kishida H, Tsukagawa M, Takahashi K, et al
    • Journal Title

      Biol Pharm Bull. 28・5

      Pages: 937-9

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590911
  • [Journal Article] Curcuminoids and sesquiterpenoids in turmeric(Curcuma longa L.)suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice2005

    • Author(s)
      Nishiyama T, Mae T, Kishida H, Tsukagawa M, Mimaki Y, Kuroda M, Sashida Y, Takahashi K, et al.
    • Journal Title

      J Agric Food Chem. 53・4

      Pages: 959-63

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590911
  • [Journal Article] Curcuminoids and sesquiterpenoids in turmeric(Curcuma longa L.)suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice2005

    • Author(s)
      Nishiyama T, Mae T, Kishida H, Tsukagawa M, Mimaki Y, Kuroda M, Sashida Y, Takahashi K, et al.
    • Journal Title

      J Agric Food Chem. 53(4)

      Pages: 959-63

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590911
  • [Journal Article] Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility.2005

    • Author(s)
      Wang, X., Ria, M., Kelmenson, P.M., Eriksson, P., Higgins, D.C., Samnegard, A., Petros C, Rollins, J., Bennet, A.M., Wiman, B., de Faire, U., Wennberg, C., Olsson, P.G., Ishii, N., Sugamura, K., Hamsten, A., Forsman-Semb, K., Lagercrantz, J., Paigen, B.
    • Journal Title

      Nat.Genet. 37

      Pages: 365-372

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] During Viral Infection of the Respiratory Tract, CD27, 4-1BB, and OX40 Collectively Determine Formation of CD8^+ Memory T Cells and Their Capacity for Secondary Expansion.2005

    • Author(s)
      Jenny Hendriks, Yanling Xiao, John W.A.Rossen, Koenraad F.van der Sluijs, Kazuo Sugamura, Naoto Ishii, Jannie Borst
    • Journal Title

      The Journal of Immunology 175

      Pages: 1665-1676

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17607001
  • [Journal Article] Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice.2005

    • Author(s)
      Kuroda M, Mimaki Y, Nishiyama T, Mae T, Kishida H, Tsukagawa M, Takahashi K, et al.
    • Journal Title

      Biol Pharm Bull. 28・5

      Pages: 937-939

    • Data Source
      KAKENHI-PROJECT-17590911
  • [Journal Article] Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice.2005

    • Author(s)
      Nishiyama T, Mae T, Kishida H, Tsukagawa M, Mimaki Y, Kuroda M, Sashida Y, Takahashi K, et al.
    • Journal Title

      J Agric Food Chem. 53・4

      Pages: 959-963

    • Data Source
      KAKENHI-PROJECT-17590911
  • [Journal Article] Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility.2005

    • Author(s)
      Wang, X., Ishii, N.ほか
    • Journal Title

      Nat.Genet (印刷中)

    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Hypoglycemic effects of turmeric(Curcuma longa L.rhizomes)on genetically diabetic KK-Ay mice2005

    • Author(s)
      Kuroda M, Mimaki Y, Nishiyama T, Mae T, Kishida H, Tsukagawa M, Takahashi K, et al.
    • Journal Title

      Biol Pharm Bull. 28(5)

      Pages: 937-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590911
  • [Journal Article] Accelerating effect of an MRL gene locus on the severity and onset of arthropathy in DBA/1 mice2005

    • Author(s)
      Oishi H
    • Journal Title

      Arthritis Rheum 52

      Pages: 959-966

    • Data Source
      KAKENHI-PROJECT-16390113
  • [Journal Article] Hrs, a mammalian master molecule in vesicular transport and protein-sorting, suppresses the degradation of ESCRT proteins STAM1 and STAM2.2005

    • Author(s)
      Kobayashi, H., Tanaka, N., Asao, H., Miura, S., Kyuuma, M., Semura, K., Ishii, N., Sugamura K.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 10468-10477

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Distinct roles for the OX40-OX40L interaction regulatory and non-regulatory T cells.2004

    • Author(s)
      Takeda, I., Ishil, N.ほか
    • Journal Title

      J.Immunol. 172

      Pages: 3580-3589

    • Data Source
      KAKENHI-PROJECT-16012205
  • [Journal Article] Expanding role of T-cell costimulators in regulatory T-cellfunction : recent advances in accessory molecules expressed onboth regulatory and non-regulatory T cells.2004

    • Author(s)
      Ndhlovu, L.C., Ishii, N., Sugamura K.ほか
    • Journal Title

      Crit.Rev.Immunol 24

      Pages: 251-266

    • Data Source
      KAKENHI-PROJECT-13226006
  • [Journal Article] Expanding role of T-cell costimulators in regulatory T-cellfunction : recent advances in accessory molecules expressed onboth regulatory and non-regulatory T cells.2004

    • Author(s)
      Ndhlovu, L.C., Takeda, I., Sugamura, K., Ishii, N.
    • Journal Title

      Crit.Rev.Immunol. 24

      Pages: 251-266

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Therapeutic targeting of the effector T cell costimulatory molecule OX402004

    • Author(s)
      Sugamura, K., Ishii, N., Weinberg, A.D
    • Journal Title

      Nat.Rev.Immunol. 4

      Pages: 420-431

    • Data Source
      KAKENHI-PROJECT-16012205
  • [Journal Article] Expanding role of T-cell costimulators in regulatory T-cellfunction : recent advances in accessory molecules expressed onboth regulatory and non-regulatory T cells.2004

    • Author(s)
      Ndhlovu, L.C., Ishii, N.ほか
    • Journal Title

      Crit.Rev.Immunol 24

      Pages: 251-266

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Therapeutic targeting of the effector T cell costimulatoiy molecule OX40.2004

    • Author(s)
      Sugamura, K., Ishii, N., Weinberg, A.D.
    • Journal Title

      Nat.Rev.Immunol. 4

      Pages: 420-431

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis.2004

    • Author(s)
      Feng, J., Misu, T., Fujihara, K., Sakoda, S., Nakatsuji, Y., Fukaura, H., Kikuchi, S., Tashiro, K., Suzumura, A., Ishii, N., Sugamura, K., Nakashima, I., Itoyama, Y.
    • Journal Title

      Multiple Sclerosis 10

      Pages: 494-498

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Distinct roles for the OX40-OX40L interaction regulatory and non-regulatory T cells.2004

    • Author(s)
      Takeda, I., Ishii, N., Sugamura K.ほか
    • Journal Title

      J.Immunol. 172

      Pages: 3580-3589

    • Data Source
      KAKENHI-PROJECT-13226006
  • [Journal Article] TNFα is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice.2004

    • Author(s)
      Horai, R., Ishii, N.ほか
    • Journal Title

      J.Clin.Invest. 114

      Pages: 1603-1611

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Adenovirus vector-mediated in vivo gene transfer of OX40 ligand to tumor cells enhances anti-tumor immunity of tumor-bearing hosts.2004

    • Author(s)
      Andarini, S., Kikuch, T., Nukiwa, M., Pradono, P., Suzuki, T., Ohkouchi, S., Inoue, A., Maemondo, M., Ishii, N., Saijo, Y., Sugamura, K., Nukiwa, T.
    • Journal Title

      Cancer Res. 64

      Pages: 3281-3287

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Adenovirus vector-mediated in vivo gene transfer of OX40 ligand to tumor cells enhances anti-tumor immunity of tumor-bearing hosts.2004

    • Author(s)
      Andrini, S., Ishii, N.ほか
    • Journal Title

      Cancer Res. 64

      Pages: 3281-3287

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Adenovirus vector-mediated in vivo gene transfer of OX40 ligand to tumor cells enhances anti-tumor immunity of tumor-bearing hosts.2004

    • Author(s)
      Andarini, S., Ishii, N.ほか
    • Journal Title

      Cancer Res. 64

      Pages: 3281-3287

    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Adenovirus vector-mediated in vivo gene transfer of OX40 ligand to tumor cells enhances anti-tumor immunity of tumor-bearing hosts.2004

    • Author(s)
      Andarini, S., Ishii, N., Sugamura, K.ほか
    • Journal Title

      Cancer Res. 64

      Pages: 3281-3287

    • Data Source
      KAKENHI-PROJECT-13226006
  • [Journal Article] Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis.2004

    • Author(s)
      Feng, J., Ishii, N.ほか
    • Journal Title

      Multiple Sclerosis 10

      Pages: 494-498

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Therapeutic targeting of the effector T cell costimulatory molecule OX402004

    • Author(s)
      Sugamura, K., Ishii, N., Weinberg, A.D
    • Journal Title

      Nat.Rev.Immunol. 4

      Pages: 420-431

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Essential role of OX40L on B cell in persistent alloantibody production following repeated alloimmunizations.2004

    • Author(s)
      Kato, H., Ishii, N.ほか
    • Journal Title

      J.Clin.Immunol. 24

      Pages: 237-248

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] TNFα is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice.2004

    • Author(s)
      Horai, R, Ishii, N.ほか
    • Journal Title

      J.Clin.Invest. 114

      Pages: 1603-1611

    • Data Source
      KAKENHI-PROJECT-16012205
  • [Journal Article] Essential role of OX40L on B cells in persistent alloantibody production following repeated alloimmunizations2004

    • Author(s)
      Kato, H., Kojima, H., Ishii, N., Hase, H., Imai, Y., Fujibayashi, T., Sugamura, K., Kobata, T.
    • Journal Title

      J.Clin.Immunol. 24

      Pages: 237-248

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Therapeutic targeting of the effector T cell costimulatory molecule OX402004

    • Author(s)
      Sugamura, K., Ishii, N., Weinberg, AD
    • Journal Title

      Nat.Rev.Immunol. 4

      Pages: 420-431

    • Data Source
      KAKENHI-PROJECT-14104011
  • [Journal Article] Therapeutic targeting of the effector T cell costimulatory molecule OX402004

    • Author(s)
      Sugamura, K., Ishii, N., Weinberg, A.D
    • Journal Title

      Nat.Rev.Immunol. 4

      Pages: 420-431

    • Data Source
      KAKENHI-PROJECT-13226006
  • [Journal Article] Expanding role of T-cell costimulators in regulatory T-cell function : recent advances in accessory molecules expressed on both regulatory and non-regulatory T cells.2004

    • Author(s)
      Ndhlovu, L.C., Ishii, N.ほか
    • Journal Title

      Crit.Rev. Immunol 24

      Pages: 251-266

    • Data Source
      KAKENHI-PROJECT-16012205
  • [Journal Article] TNFα is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice.2004

    • Author(s)
      Horai, R., Nakajima, A., Habiro, K., Kotani, M., Nakae, S., Matsuki, T, Nambu, A., Saijo, S., Kotaki, H., Sudo, K., Okahara, A., Tanioka, H., Ikuse, T., Ishii, N., Schwartzberg, P.L., Abe, R., Iwakura, Y.
    • Journal Title

      J.Clin.Invest. 114

      Pages: 1603-1611

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Distinct roles for the OX40-OX40L interaction in regulatory and non-regulatory T cells.2004

    • Author(s)
      Takeda, I., Ine, S., Killeen, N., Ndhlovu, L.C., Murata, K., Satomi, S., Sugamura, K., Ishii, N.
    • Journal Title

      J.Immunol. 172

      Pages: 3580-3589

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Adenovirus vector-mediated in vivo gene transfer of OX40 ligand to tumor cells enhances anti-tumor immunity of tumor-bearing hosts.2004

    • Author(s)
      Andarini, S., Ishii, N.ほか
    • Journal Title

      Cancer Res. 64

      Pages: 3281-3287

    • Data Source
      KAKENHI-PROJECT-16012205
  • [Journal Article] Distinct roles for the OX40-OX40L interaction regulatory and non-regulatory T cells.2004

    • Author(s)
      Takeda, I., Ishii, N.ほか
    • Journal Title

      J.Immunol 172

      Pages: 3580-3589

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation.2003

    • Author(s)
      Kanazawa, C., Morita, E., Yamada, M., Ishii, N., Miura, S., Asao, H., Yoshimori, T., Sugamura, K.
    • Journal Title

      Biochem.Biophys.Res.Commun. 309

      Pages: 848-856

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif.2003

    • Author(s)
      Kikuchi, K., Ishii, N.ほか
    • Journal Title

      Biochem.Biophys.Res.Commun 306

      Pages: 637-643

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation.2003

    • Author(s)
      Kanazawa, C., Ishii, N.ほか
    • Journal Title

      Biochem.Biophys.Res.Commun. 309

      Pages: 848-856

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses.2003

    • Author(s)
      Ishii, N., Ndhlovu, L.C., Murata, K., Sato, T., Kamanaka, M., Sugamura, K.
    • Journal Title

      Eur.J.Immunol. 33

      Pages: 2372-2381

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif.2003

    • Author(s)
      Kikuchi, K., Ishii, N., Asao, H., Sugamura, K.
    • Journal Title

      Biochem.Biophys.Res.Commun. 306

      Pages: 637-643

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma.2003

    • Author(s)
      Hoshino, A., Tanaka, Y., Akiba, H., Asakura, Y., Mita, Y., Sakurai, T., Takaoka, A., Nakaike, S., Ishii, N., Sugamura, K., Yagita, H., Okumura, K.
    • Journal Title

      Eur.J.Immunol. 33

      Pages: 861-869

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] OX40(CD134)and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses.2003

    • Author(s)
      Ishii, N., Ndhlovu, L.C.ほか
    • Journal Title

      Eur.J.Immunol. 33

      Pages: 2372-2381

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Critical role of OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma.2003

    • Author(s)
      Hoshino, A., Ishii, N.ほか
    • Journal Title

      Eur.J.Immunol. 33

      Pages: 861-869

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390155
  • [Journal Article] Grf40, a novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT.1999

    • Author(s)
      Asada, H., Ishii, N., Sasaki, Y., Endo, K., Kasai, H., Tanaka, N., Takeshita, T., Tsuchiya, S., Konno, T., Sugamura, K.
    • Journal Title

      J.Exp.Med. Vol.189

      Pages: 1383-1390

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-10470084
  • [Journal Article] Human parvovirus B19 as a causative agent for rheumatoid arthritis.1998

    • Author(s)
      Takahashi, Y., Murai, C., Shibata, S., Munakata, Y., Ishii, T., Ishii, K., Saitoh, T., Sawai, T., Sugamura, K., Sasaki, T.
    • Journal Title

      Proc.Natl.Acad.Sci.USA, Vol.95, 14

      Pages: 8227-8232

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-10470074
  • [Journal Article] Prolongation of allograft survival by administration of mAb specific for the three subunis of IL-2 receptor.1998

    • Author(s)
      Yasuda, K., Nemoto, T., Ohashi, Y., Satomi, S., Mutara, K., Ishii, N., Takeshita, T., Sugamura, K.
    • Journal Title

      Int.Immunol. Vol.10

      Pages: 561-567

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-10470084
  • [Patent] 発明の名称 : 肺高血圧症のモデル動物作成法、肺高血圧症治療法、および治療薬物2006

    • Inventor(s)
      下川宏明, 小野栄夫, 菅村和夫, 石井直人, 佐藤公雄
    • Industrial Property Rights Holder
      下川宏明, 小野栄夫, 菅村和夫, 石井直人, 佐藤公雄
    • Industrial Property Number
      2006-008242
    • Filing Date
      2006-11-07
    • Acquisition Date
      2006-12-15
    • Data Source
      KAKENHI-PROJECT-18659218
  • [Presentation] Basic characterization of TNF ligand-based agonists targeting OX40, 4-1BB, CD27, and GITR expressed by T cells.2024

    • Author(s)
      Takanori So, Hodaka Nagai, Mitsuki Azuma, Ayaka Sato, Ayano Suzuki, Aya Ito, Masashi Morita, Mari Hikosaka-Kuniishi, Naoto Ishii.
    • Organizer
      The 52nd Annual Meeting of the Japanese Society for Immunology.
    • Data Source
      KAKENHI-PROJECT-23K18212
  • [Presentation] Reactive persulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation.2024

    • Author(s)
      Shunichi Tayama, Yuya Kitamura, Kyoga Hiraide, Hibiki Suzuki, Jing Li, Ziying Yang, Kosuke Sato, Akihisa Kawajiri, Yuko Okuyama, Takeshi Kawabe, Takaaki Akaike, Naoto Ishii.
    • Organizer
      第52回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] Memory-phenotype CD4+ T lymphocytes can contribute to tumor control without inducing graft-versus-host disease.2024

    • Author(s)
      Ziying Yang, Jing Li, Hideaki Watanabe, Keita Koinuma, Akihisa Kawajiri, Kosuke Sato, Shunichi Tayama, Yuko Okuyama, Naoto Ishii, Takeshi Kawabe.
    • Organizer
      第52回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] Regulatory T cells tonically inhibit spontaneous activation of naturally arising memory-phenotype CD4+ T lymphocytes.2024

    • Author(s)
      Jing Li, Ziying Yang, Akihisa Kawajiri, Kosuke Sato, Shunichi Tayama, Naoto Ishii, Takeshi Kawabe.
    • Organizer
      第52回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] Structural and functional characterization of recombinant OX40 ligand fusion proteins.2024

    • Author(s)
      Ayaka Sato, Mitsuki Azuma, Hodaka Nagai, Aya Ito, Masashi Morita, Mari Hikosaka-Kuniishi, Naoto Ishii, Takanori So.
    • Organizer
      The 52nd Annual Meeting of the Japanese Society for Immunology.
    • Data Source
      KAKENHI-PROJECT-23K18212
  • [Presentation] Functional characterization of antibody fusion-single-chain TNF proteins that agonize costimulatory TNFR expressed by T cells.2024

    • Author(s)
      Hodaka Nagai, Mitsuki Azuma, Ayaka Sato, Sayaka Ogawara, Yuta Tsutsui, Ayano Suzuki, Shimpei Matsuyama, Tomomi Wakaizumi, Masashi Morita, Mari Hikosaka-Kuniishi, Naoto Ishii, Takanori So.
    • Organizer
      The 52nd Annual Meeting of the Japanese Society for Immunology.
    • Data Source
      KAKENHI-PROJECT-23K18212
  • [Presentation] Memory-phenotype CD4+ T lymphocytes rapidly accumulate in ischemic organs and exacerbate tissue injury in an innate manner.2024

    • Author(s)
      Kosuke Sato, Akihisa Kawajiri, Jing Li, Ziying Yang, Shunichi Tayama, Kenshiro Matsuda, Chigusa Oda, Akira Shibuya, Motoshi Wada, Naoto Ishii, Takeshi Kawabe.
    • Organizer
      第52回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] Mitochondrial cysteinyl-tRNA synthetase (CARS2) -dependent sulfur metabolism exacerbates a mouse model of multiple sclerosis through antigen presentation.2024

    • Author(s)
      Hibiki Suzuki, Kyoga Hiraide, Yuya Kitamura, Shunichi Tayama, Kosuke Sato, Keita Koinuma, Yuko Okuyama, Takeshi Kawabe, Takaaki Akaike, Naoto Ishii.
    • Organizer
      第52回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] CD127 and Sca1 mark self-driven memory-phenotype CD4+ T cells that differ from foreign antigen-specific memory cells and possess inflammatogenic and anti-tumor activities.2023

    • Author(s)
      Takeshi Kawabe, Thomas Ciucci, Kwang Soon Kim, Ziying Yang, Akihisa Kawajiri, Shunichi Tayama, Naoto Ishii, Dragana Jankovic, Jinfang Zhu, Jonathan Sprent, Remy Bosselut, Alan Sher.
    • Organizer
      Immunology 2023, Annual Meeting of the American Association of Immunologists
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] Reactive persulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation.2023

    • Author(s)
      Shunichi Tayama, Yuya Kitamura, Kyoga Hiraide, Jing Li, Ziying Yang, Akihisa Kawajiri, Kosuke Sato, Yuko Okuyama, Takeshi Kawabe, Takaaki Akaike, Naoto Ishii.
    • Organizer
      Immunology 2023, Annual Meeting of the American Association of Immunologists
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] Functional evaluation of single-chain TNF ligand-Fc fusion proteins for activation of co-stimulatory TNF receptors expressed by T-lymphocytes.2023

    • Author(s)
      Hodaka Nagai, Mitsuki Azuma, Ayaka Sato, Nagito Shibui, Sayaka Ogawara, Yuta Tsutsui, Ayano Suzuki, Tomomi Wakaizumi, Aya Ito, Shimpei Matsuyama, Masashi Morita, Mari Hikosaka-Kuniishi, Takanori So.
    • Organizer
      7th Toyama-Basel Joint Symposium 2023.
    • Data Source
      KAKENHI-PROJECT-23K18212
  • [Presentation] Structural requirement of soluble OX40 ligand protein for efficient induction of co-stimulatory signaling mediated by OX40.2023

    • Author(s)
      Ayaka Sato, Mitsuki Azuma, Hodaka Nagai, Nagito Shibui, Sayaka Ogawara, Yuta Tsustui, Ayano Suzuki, Aya Ito, Tomomi Wakaizumi, Shimpei Matsuyama, Masashi Morita, Mari Hikosaka-Kuniishi, Takanori So.
    • Organizer
      7th Toyama-Basel Joint Symposium 2023.
    • Data Source
      KAKENHI-PROJECT-23K18212
  • [Presentation] Self antigen-driven, undifferentiated memory-phenotype CD4+ T lymphocytes can induce mild and systemic inflammation by differentiating into effector and regulatory T cells.2023

    • Author(s)
      Akihisa Kawajiri, Jing Li, Ziying Yang, Keita Koinuma, Hye Jin Yoon, Minami Ishii, Shunichi Tayama, Kosuke Sato, Yuko Okuyama, Hideo Harigae, Naoto Ishii, Kazuyoshi Ishigaki, Jinfang Zhu, Kwang Soon Kim, Takeshi Kawabe.
    • Organizer
      Immunology 2023, Annual Meeting of the American Association of Immunologists
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] Excess proliferation and activation of self-reactive memory-phenotype CD4+ T lymphocytes are tonically inhibited by regulatory T cells in steady state.2022

    • Author(s)
      Jing Li, Ziying Yang, Akihisa Kawajiri, Kosuke Sato, Shunichi Tayama, Yuko Okuyama, Naoto Ishii, Takeshi Kawabe
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24146
  • [Presentation] Immunological Functions of Memory-Phenotype CD4+ T lymphocytes in Anti-Tumor Responses and Graft-versus-Host Disease.2022

    • Author(s)
      Ziying Yang, Hideaki Watanabe, Jing Li, Akihisa Kawajiri, Kosuke Sato, Shunichi Tayama, Yuko Okuyama, Naoto Ishii, Takeshi Kawabe
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] Self-reactive memory-phenotype CD4+ T lymphocytes can induce mild and systemic inflammation by differentiating into effector and regulatory T cells.2022

    • Author(s)
      Akihisa Kawajiri, Jing Li, Ziying Yang, Keita Koinuma, Kosuke Sato, Shunichi Tayama, Yuko Okuyama, Hideo Harigae, Naoto Ishii, Jinfang Zhu, Kwang Soon Kim, Takeshi Kawabe
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24146
  • [Presentation] Rapid accumulation of circulating memory-phenotype CD4+ T lymphocytes in the gut critically contributes to tissue injury driven by intestinal ischemia and reperfusion.2022

    • Author(s)
      Kosuke Sato, Jing Li, Ziying Yang, Akihisa Kawajiri, Shunichi Tayama, Yuko Okuyama, Motoshi Wada, Naoto Ishii, Takeshi Kawabe
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24146
  • [Presentation] Phenotypic and functional analyses reveal self-driven memory-phenotype CD4+ T lymphocytes as a heterogeneous population distinct from foreign antigen-specific memory cells.2022

    • Author(s)
      Takeshi Kawabe, Thomas Ciucci, Kwang Soon Kim, Shunichi Tayama, Akihisa Kawajiri, Naoto Ishii, Dragana Jankovic, Jinfang Zhu, Jonathan Sprent, Remy Bosselut, Alan Sher
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24146
  • [Presentation] CARS2-dependent sulfur metabolism controls intestinal inflammation by suppressing CD4+ T cell proliferation.2022

    • Author(s)
      Shunichi Tayama, Takeshi Kawabe, Kyoga Hiraide, Jing Li, Ziying Yang, Kosuke Sato, Akihisa Kawajiri, Yuko Okuyama, Naoto Ishii
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24146
  • [Presentation] 自己抗原反応性Memory-phenotype CD4+T細胞の炎症惹起能2022

    • Author(s)
      川尻昭寿, 李静, 楊子嬰, 鯉沼佳太, 佐藤皓祐, 田山舜一, 奥山祐子, 張替秀郎, 石井直人, 河部剛史
    • Organizer
      第74回日本細菌学会東北支部会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] Mitochondrial cysteinyl-tRNA synthetase (CARS2)-dependent sulfur metabolism exacerbates experimental autoimmune encephalomyelitis in mice.2022

    • Author(s)
      Kyoga Hiraide, Yuya Kitamura, Shunichi Tayama, Yuko Okuyama, Kosuke Sato, Hibiki Suzuki, Keita Koinuma, Takeshi Kawabe, Naoto Ishii
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] 自己抗原反応性Memory-phenotype CD4+T細胞の炎症惹起能2022

    • Author(s)
      川尻昭寿, 李静, 楊子嬰, 鯉沼佳太, 佐藤皓祐, 田山舜一, 奥山祐子, 張替秀郎, 石井直人, 河部剛史
    • Organizer
      第74回日本細菌学会東北支部会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24146
  • [Presentation] ILC2-derived OX40L-OX40 signal promotes cytotoxic CD8+ T cell-mediated antitumor immunity in murine melanoma.2022

    • Author(s)
      Yuko Okuyama, Akira Okajima, Nao Sakamoto, Ryuto Tanabe, Ayaka Hashimoto, Atsuko Asao, Ziying Yang, Akihisa Kawajiri, Takeshi Kawabe, Naoto Ishii
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] Mitochondrial cysteinyl-tRNA synthetase (CARS2)-dependent sulfur metabolism exacerbates experimental autoimmune encephalomyelitis in mice.2022

    • Author(s)
      Kyoga Hiraide, Yuya Kitamura, Shunichi Tayama, Yuko Okuyama, Kosuke Sato, Hibiki Suzuki, Keita Koinuma, Takeshi Kawabe, Naoto Ishii
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24146
  • [Presentation] Excess proliferation and activation of self-reactive memory-phenotype CD4+ T lymphocytes are tonically inhibited by regulatory T cells in steady state.2022

    • Author(s)
      Jing Li, Ziying Yang, Akihisa Kawajiri, Kosuke Sato, Shunichi Tayama, Yuko Okuyama, Naoto Ishii, Takeshi Kawabe
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] Immunological Functions of Memory-Phenotype CD4+ T lymphocytes in Anti-Tumor Responses and Graft-versus-Host Disease.2022

    • Author(s)
      Ziying Yang, Hideaki Watanabe, Jing Li, Akihisa Kawajiri, Kosuke Sato, Shunichi Tayama, Yuko Okuyama, Naoto Ishii, Takeshi Kawabe
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24146
  • [Presentation] Rapid accumulation of circulating memory-phenotype CD4+ T lymphocytes in the gut critically contributes to tissue injury driven by intestinal ischemia and reperfusion.2022

    • Author(s)
      Kosuke Sato, Jing Li, Ziying Yang, Akihisa Kawajiri, Shunichi Tayama, Yuko Okuyama, Motoshi Wada, Naoto Ishii, Takeshi Kawabe
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] Self-reactive memory-phenotype CD4+ T lymphocytes can induce mild and systemic inflammation by differentiating into effector and regulatory T cells.2022

    • Author(s)
      Akihisa Kawajiri, Jing Li, Ziying Yang, Keita Koinuma, Kosuke Sato, Shunichi Tayama, Yuko Okuyama, Hideo Harigae, Naoto Ishii, Jinfang Zhu, Kwang Soon Kim, Takeshi Kawabe
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] ILC2-derived OX40L-OX40 signal promotes cytotoxic CD8+ T cell-mediated antitumor immunity in murine melanoma.2022

    • Author(s)
      Yuko Okuyama, Akira Okajima, Nao Sakamoto, Ryuto Tanabe, Ayaka Hashimoto, Atsuko Asao, Ziying Yang, Akihisa Kawajiri, Takeshi Kawabe, Naoto Ishii
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24146
  • [Presentation] CARS2-dependent sulfur metabolism controls intestinal inflammation by suppressing CD4+ T cell proliferation.2022

    • Author(s)
      Shunichi Tayama, Takeshi Kawabe, Kyoga Hiraide, Jing Li, Ziying Yang, Kosuke Sato, Akihisa Kawajiri, Yuko Okuyama, Naoto Ishii
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] Phenotypic and functional analyses reveal self-driven memory-phenotype CD4+ T lymphocytes as a heterogeneous population distinct from foreign antigen-specific memory cells.2022

    • Author(s)
      Takeshi Kawabe, Thomas Ciucci, Kwang Soon Kim, Shunichi Tayama, Akihisa Kawajiri, Naoto Ishii, Dragana Jankovic, Jinfang Zhu, Jonathan Sprent, Remy Bosselut, Alan Sher
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K19418
  • [Presentation] TRAF5 による CD4+ T 細胞の IL-27 受容体シグナル調節機構2021

    • Author(s)
      河原 永悟,藤森 由夏,大石 真結,川口 甲介,守田 雅志,奥山 祐子,石井 直人,宗 孝紀
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-18H02572
  • [Presentation] TNF receptor-associated factor 5 inhibits IL-27 receptor signaling in CD4+ T-lymphocytes2019

    • Author(s)
      Eigo Kawahara, Yuka Fujimori, Mayu Oishi, Masashi Morita, Yuko Okuyama, Naoto Ishii, Takanori So.
    • Organizer
      第48回日本免疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] TNFR-associated factor (TRAF) 5 expressed by intestinal epithelial cells promotes NF-kB-mediated inflammation via controlling TRAF2 stability in dextran sulfate sodium-induced colitis2019

    • Author(s)
      Hai T Phung, Hiroyuki Nagashima, Shuhei Kobayashi, Tomoaki Machiyama, Tsuyoshi Sakurai, Shun-ichi Tayama, Atsuko Asao, Yuko Okuyama, Naoto Ishii, Takanori So.
    • Organizer
      第48回日本免疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] IQGAP1 regulates ILC2 apoptosis in the lung2019

    • Author(s)
      Tayama S, Okuyama Y, Phung HT, Kawabe T, So T, Ishii N
    • Organizer
      第48回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02572
  • [Presentation] IQGAP1 regulates ILC2 apoptosis in the lung2019

    • Author(s)
      Shun-ichi Tayama, Yuko Okuyama, Phung The Hai, Takeshi Kawabe, Takanori So, Naoto Ishii.
    • Organizer
      第48回日本免疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] TNFR-associated factor (TRAF) 5 expressed by intestinal epithelial cells promotes NF-kB-mediated inflammation via controlling TRAF2 stability in dextran sulfate sodium-induced colitis2019

    • Author(s)
      Phung HT, Nagashima H, Kobayashi S, Machiyama T, Sakurai T, Tayama S, Asao A, Okuyama Y, Ishii N, So T
    • Organizer
      第48回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02572
  • [Presentation] TNF receptor-associated factor 5 inhibits IL-27 receptor signaling in CD4+ T-lymphocytes2019

    • Author(s)
      Kawahara E, Fujimori Y, Oishi M, Morita M, Ishii N, Okuyama Y, So T
    • Organizer
      第48回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02572
  • [Presentation] GITR co-signaling controls group 2 innate lymphoid cells in allergic lung inflammation.2019

    • Author(s)
      Yuko Okuyama, Hiroyuki Nagashima, Kazuyo Moro, Lishomwa C. Ndhlovu, Carlo Riccardi, Takanori So, Naoto Ishii.
    • Organizer
      第17回国際免疫学会議 (ICI 2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] Understanding the role of TRAF family proteins in gp130 signaling2019

    • Author(s)
      Fujimori Y, Kawahara E, Morita M, Okuyama Y, Ishii N, So T
    • Organizer
      第48回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02572
  • [Presentation] Understanding the role of TRAF family proteins in gp130 signaling2019

    • Author(s)
      Yuka Fujimori, Eigo Kawahara, Masashi Morita, Yuko Okuyama, Naoto Ishii, Takanori So.
    • Organizer
      第48回日本免疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] サイトカイン受容体 gp130 と TRAF タンパク質の相互作用様式の解明2019

    • Author(s)
      藤森由夏,河原永悟,川口甲介,守田雅志,帯田孝之,奥山祐子,水口峰之,石井直人,宗孝紀
    • Organizer
      日本薬学会北陸支部第131回例会
    • Data Source
      KAKENHI-PROJECT-18H02572
  • [Presentation] GITR signaling negatively controls DSS-induced intestinal inflammation by regulating NK cells function2019

    • Author(s)
      Sakurai T, Okuyama Y, Hai Phung HT, So T, Nio M, Ishii N
    • Organizer
      第48回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02572
  • [Presentation] GITR signaling negatively controls DSS-induced intestinal inflammation by regulating NK cells function.2019

    • Author(s)
      Tsuyoshi Sakurai, Yuko Okuyama, Phung The Hai, Takanori So, Naoto Ishii.
    • Organizer
      第48回日本免疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] CD4陽性T細胞のIL-27受容体シグナルにおけるTRAF5の抑制性機能の解明2019

    • Author(s)
      河原永悟,藤森由夏,大石真結,川口甲介,守田雅志,奥山祐子,石井直人,宗孝紀
    • Organizer
      日本薬学会北陸支部第131回例会
    • Data Source
      KAKENHI-PROJECT-18H02572
  • [Presentation] TRAF5 maintains the expression level of TRAF2 in non-hematopoietic cells and exacerbates DSS-colitis in mice2018

    • Author(s)
      Hai The Phung, Hiroyuki Nagashima, Shuhei Kobayashi, Tomoaki Machiyama, Atsuko Asao, Yuko Okuyama, Naoto Ishii, Takanori So
    • Organizer
      第47回日本免疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] GITR signaling regulates intestinal inflammation by suppressing NK cells function in DSS-induced colitis model2018

    • Author(s)
      Tsuyoshi Sakurai, Yuko Okuyama, Shuhei Kobayashi, Masaki Nio, Naoto Ishii
    • Organizer
      第47回日本免疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] Functional regulation of plasmacytoid dendritic cells by TNF receptor associated factor 5.2018

    • Author(s)
      Kobayashi S, Sakurai T, Asao A, Phung HT, So T, Ishii N.
    • Organizer
      第47回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02572
  • [Presentation] TRAF5 maintains the expression level of TRAF2 in nonhematopoietic cells and exacerbates DSS-colitis in mice.2018

    • Author(s)
      Phung HT, Nagashima H, Kobayashi S, Machiyama T, Asao A, Okuyama Y, Ishii N, So T.
    • Organizer
      第47回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02572
  • [Presentation] 炎症性腸疾患におけるGITRを介したNK細胞による制御機構2018

    • Author(s)
      櫻井 毅,奥山祐子,小林周平,仁尾正記,石井直人
    • Organizer
      第72回日本細菌学会東北支部総会
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] GITR co-signaling controls group 2 innate lymphoid cells through IL-9 induction in allergic lung inflammation2018

    • Author(s)
      Yuko Okuyama, Hiroyuki Nagashima, Yasutaka Motomura, Kazuyo Moro, Lishomwa C. Ndhlovu, Carlo Riccardi, Takanori So, Naoto Ishii
    • Organizer
      第47回日本免疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation.2018

    • Author(s)
      Machiyama T, So T, Harigae H, Ishii N.
    • Organizer
      第47回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02572
  • [Presentation] TNF receptor-associated factor 5 expressed in non-hematopoietic cells augments acute colonic damage induced by dextran sulfate sodium2018

    • Author(s)
      Hai The Phung, Hiroyuki Nagashima, Shuhei Kobayashi, Tomoaki Machiyama, Atsuko Asao, Yuko Okuyama, Naoto Ishii, Takanori So
    • Organizer
      The 11th Vietnam-Japan Scientific Exchange Meeting
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] IQGAP1 is essencial for ILC2 maintenance in the lung2018

    • Author(s)
      Shunichi Tayama, Yuko Okuyama, Takanori So, Naoto Ishii
    • Organizer
      The 11th Vietnam-Japan Scientific Exchange Meeting
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] GITR co-signaling controls group 2 innate lymphoid cells through IL-9 induction in allergic lung inflammation.2018

    • Author(s)
      Okuyama Y, Nagashima H, Motomura Y, Moro K, Sakurai T, Ndhlovu LC, Riccardi C, So T, Ishii N.
    • Organizer
      第47回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02572
  • [Presentation] GITRによる2型自然リンパ球の活性化を介したアレルギー性肺炎症の制御機構2018

    • Author(s)
      奥山 祐子,長島 宏行,宗 孝紀,石井 直人
    • Organizer
      第72回日本細菌学会東北支部総会
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] A new regulator of OX40 co-signaling controls autoimmune neuroin ammation mediated by CD4+ T cells2017

    • Author(s)
      Yuko Okuyama, Hiroyuki Nagashima, Masuko Ushio-Fukai, Michael Croft, Naoto Ishii, Takanori So
    • Organizer
      第46回日本免疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] TNF受容体型分子 GITRによる2型自然リンパ球制御機構2017

    • Author(s)
      宗孝紀, 長島宏行, 藤田剛, 武田武生, 奥山祐子, 本村泰隆, 茂呂和世, 大森公貴, Ndhlovu LC, Riccardi C, 石井直人
    • Organizer
      第3回日本骨免疫学会
    • Data Source
      KAKENHI-PROJECT-15H04640
  • [Presentation] TRAF2 and TRAF5 binding to the signal transducing receptor gp130 inhibit JAK1 activation in the IL-6-receptor signaling complex2017

    • Author(s)
      Masanobu Kimura, Hiroyuki Nagashima, Naoto Ishii, Takanori So
    • Organizer
      日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K15508
  • [Presentation] TRAF2 and TRAF5 binding to the signal transducing receptor gp130 inhibit JAK1 activation in the IL-6-receptor signaling complex2017

    • Author(s)
      Kimura M., Nagashima H, Ishii N, So T
    • Organizer
      第46回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-15H04640
  • [Presentation] Early activation of group 2 innate lymphoid cells in the lung is critically controlled by the TNFR superfamily molecule GITR2017

    • Author(s)
      Takanori So, Hiroyuki Nagashima, Yuko Okuyama, Yasutaka Motomura, Kazuyo Moro, Lishomwa C. Ndhlovu, Carlo Riccardi, Naoto Ishii
    • Organizer
      日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] Early activation of group 2 innate lymphoid cells in the lung is critically controlled by the TNFR superfamily molecule GITR2017

    • Author(s)
      So T, Nagashima H, Okuyama Y, Motomura Y, Moro K, Ndhlovu LC, Riccardi C, Ishii N
    • Organizer
      第46回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-15H04640
  • [Presentation] TNF receptor-associated factors 5 expressed in non-hematopoietic cells augments acute colonic damage induced by dextran sulfate2017

    • Author(s)
      HAI T PHUNG, Hiroyuki Nagashima, Yuko Okuyama, Shuhei Kobayashi, Atsuko Asao, Naoto Ishii, Takanori So
    • Organizer
      日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] Early activation of group 2 innate lymphoid cells in the lung is critically controlled by the TNFR superfamily molecule GITR2017

    • Author(s)
      Takanori So, Hiroyuki Nagashima, Yuko Okuyama, Yasutaka Motomura, Kazuyo Moro, Lishomwa C. Ndhlovu, Carlo Riccardi, Naoto Ishii
    • Organizer
      日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K15508
  • [Presentation] OX40 binding and regulation of T cell activation by the scaffolding IQGAP1 protein2017

    • Author(s)
      Okuyama, Y., Nagashima, H., Ushio-Fukai, M., Croft, M., Ishii, N., So, T.
    • Organizer
      The 2017 Japan-NIH Joint Symposium on Advances in Biomedical Reserch and Disease
    • Place of Presentation
      Seiryo Auditorium, Tohoku University, Sendai, Japan
    • Year and Date
      2017-02-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04640
  • [Presentation] A novel regulatory role for TRAF2 and TRAF5 in the IL-6-driven Th17 development.2017

    • Author(s)
      NAGASHIMA Hiroyuki, OKUYAMA Yuko, HAYASHI Takaya, ISHII Naoto, SO Takanori
    • Organizer
      2017 Japan-NIH Joint Symposium
    • Place of Presentation
      星陵オーディトリアム、仙台
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] novel regulatory role for TRAF2 and TRAF5 in the IL-6-driven Th17 development2017

    • Author(s)
      Nagashima, H., Okuyama, Y., Hayashi, T., Ishii, N., So, T.
    • Organizer
      The 2017 Japan-NIH Joint Symposium on Advances in Biomedical Reserch and Disease
    • Place of Presentation
      Seiryo Auditorium, Tohoku University, Sendai, Japan
    • Year and Date
      2017-02-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04640
  • [Presentation] TRAF2 and TRAF5 binding to the signal transducing receptor gp130 inhibit JAK1 activation in the IL-6-receptor signaling complex2017

    • Author(s)
      Masanobu Kimura, Hiroyuki Nagashima, Naoto Ishii, Takanori So
    • Organizer
      日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] TNF receptor-associated factors 5 expressed in non-hematopoietic cells augments acute colonic damage induced by dextran sulfate2017

    • Author(s)
      HAI T PHUNG, Hiroyuki Nagashima, Yuko Okuyama, Shuhei Kobayashi, Atsuko Asao, Naoto Ishii, Takanori So
    • Organizer
      日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K15508
  • [Presentation] A new regulator of OX40 co-signaling controls autoimmune neuroinflammation mediated by CD4+ T cells2017

    • Author(s)
      Yuko Okuyama, Hiroyuki Nagashima, Masuko Ushio-Fukao, Michael Croft, Naoto Ishii, Takanori So
    • Organizer
      日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] A new regulator of OX40 co-signaling controls autoimmune neuroinflammation mediated by CD4+ T cells2017

    • Author(s)
      Yuko Okuyama, Hiroyuki Nagashima, Masuko Ushio-Fukao, Michael Croft, Naoto Ishii, Takanori So
    • Organizer
      日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K15508
  • [Presentation] A new regulator of OX40 co-signaling controls autoimmune neuroinflammation mediated by CD4+ T cells2017

    • Author(s)
      Okuyama Y, Nagashima H, Ushio-Fukai M, Croft M, Ishii N, So T
    • Organizer
      第46回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-15H04640
  • [Presentation] Early activation of group 2 innate lymphoid cells in the lung is critically controlled by the TNFR superfamily molecule GITR2017

    • Author(s)
      Takanori So, Hiroyuki Nagashima, Yuko Okuyama, Yasutaka Motomura, Kazuyo Moro, Lishomwa C. Ndhlovu, Carlo Ricardi, Naoto Ishii
    • Organizer
      第46回日本免疫学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] TNF receptor-associated factor 5 expressed in non-hematopoietic cells augments acute colonic damage induced by dextran sulfate sodium2017

    • Author(s)
      Phung HT, Nagashima H, Okuyama Y, Kobayashi S, Asao A, Ishii N, So T
    • Organizer
      第46回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-15H04640
  • [Presentation] アレルギー性肺炎症における 2型自然リンパ球のGITRによる制御機構2017

    • Author(s)
      奥山 祐子, 長島 宏行 , 藤田 剛 , 宗 孝紀 , 石井 直人
    • Organizer
      第71回日本細菌学会東北支部総会
    • Data Source
      KAKENHI-PROJECT-17K08875
  • [Presentation] Traf2とTraf5を介したインターロイキン6(IL-6)シグナル制御2016

    • Author(s)
      長島宏行、石井直人
    • Organizer
      第5回 Multidisciplinary meeting on atherosclerosis
    • Place of Presentation
      仙台トラストシティ カンファレンスルーム、宮城県仙台市
    • Year and Date
      2016-01-09
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] OX40 binding and regulation of T cell activation by the scaffolding IQGAP1 protein2016

    • Author(s)
      Okuyama, Y., Nagashima,H., Machiyama, T., Ushio-Fukai, M., Croft, M., Ishii, N., So, T.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-15H04640
  • [Presentation] CD4+ T cell-intrinsic TRAF5 negatively regulates Th17 cell-dependent experimental autoimmune encephalomyelitis2016

    • Author(s)
      Nagashima, H., Okuyama, Y., Hayashi, T., Asao, A., Kawabe, T., Yamaki, S., Nakano, H., Croft, M., Ishii, N., So, T.
    • Organizer
      16th International Congress of Immunology
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04640
  • [Presentation] TRAF adaptors limit IL-6 receptor signaling through an unexpected binding to the signaling transducer receptor gp1302016

    • Author(s)
      So, T., Nagashima, H., Okuyama, Y., Hayashi, T., Asao, A., Kawabe, T., Yamaki, S., Nakano, H., Croft, M., Ishii, N.
    • Organizer
      16th International Congress of Immunology
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04640
  • [Presentation] TRAF2 and TRAF5 have redundant but unequal inhibitory roles in Th17 differentiation mediated by IL-62016

    • Author(s)
      Nagashima, H., Okuyama,Y., Hayashi, T., Ishii, N., So, T.
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-15H04640
  • [Presentation] CD4+ T cell-intrinsic TRAF5 negatively regulates Th17 cell-dependent experimental autoimmune encephalomyelitis2016

    • Author(s)
      Hiroyuki Nagashima, Yuko Okuyama, Takaya Hayashi, Atsuko Asao, Takeshi Kawabe, Satoshi Yamaki, Hiroyasu Nakano, Michael Croft, Naoto Ishii, Takanori So
    • Organizer
      International congress of immunology (ICI) 2016
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] TRAF2 and TRAF5 have redundant but unequal inhibitory roles in Th17 differentiation mediated by IL-62016

    • Author(s)
      NAGASHIMA Hiroyuki, OKUYAMA Yuko, HAYASHI Takaya, ISHII Naoto, SO Takanori
    • Organizer
      45th Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      沖縄コンベンションセンター、宜野湾
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] International Congress of Immunology 20162016

    • Author(s)
      So, T., H. Nagashima, Y. Okuyama, T. Hayashi, A. Asao, T. Kawabe, S. Yamaki, H. Nakano, M. Croft, N. Ishii.
    • Organizer
      TRAF adaptors limit IL-6 receptor signaling through an unexpected binding to the signaling transducer receptor gp130
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] IQGAP1 regulates OX40 co-signaling in CD4+ T cells2015

    • Author(s)
      Yuko Okuyama, Hiroyuki Nagashima, Masuko Ushio-Fukai, Michael Croft, Naoto Ishii, Takanori So
    • Organizer
      The 44th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-15H04640
  • [Presentation] TRAF2 and TRAF5 limit the differentiation of Th17 cells mediated by IL-62015

    • Author(s)
      Hiroyuki Nagashima, Yuko Okuyama, Takaya Hayashi, Naoto Ishii, Takanori So
    • Organizer
      The 44th Annual Meeting of The Japanese Society for Immunology
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-15H04640
  • [Presentation] TRAF2 and TRAF5 limit the differentiation of Th17 cells mediated by IL-62015

    • Author(s)
      長島宏行、奥山祐子、林隆也、石井直人、宗孝紀
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター、北海道札幌市
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] Role of mesenteric lymphnodes in CD4 T cell homeostasis2015

    • Author(s)
      Naoto Ishii
    • Organizer
      1st Symposium of Creation and Future Trends in Food and Agricultural Immunology
    • Place of Presentation
      Multimedia Education and Research Complex, Tohoku University, Miyagi、Sendai
    • Year and Date
      2015-12-12
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] Investigating the Role of the Immune Checkpoint Receptor TIGIT in T cells during HIV Disease Progression and as Target for Immune Restoration2015

    • Author(s)
      Glen M. Chew, Tsuyoshi Fujita, Gabriela Webb, Benjamin J. Burwitz, Kiera L. Clayton, Naoto Ishii, Mohamed Abdel-Mohsen, Teri Liegler, Fredrick M. Hecht, Mario Ostrowski, Mark Maurer, Alan J. Korman, Steven G. Deeks, Jonah B. Sacha and Lishomwa C. Ndhlovu
    • Organizer
      8th Conference of International AIDS association
    • Place of Presentation
      Vancourver, Canada
    • Year and Date
      2015-07-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] IQGAP1 regulates OX40 co-signaling in CD4+ T cells2015

    • Author(s)
      奥山祐子、長島宏行、Masuko Ushio-Fukai、Michael Croft、石井直人、宗孝紀
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター、北海道札幌市
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] OX40-mediated susceptibility to imiquimod-induced psoriasis-like skin inflammation is dependent on IL-132015

    • Author(s)
      浅尾敦子、藤田剛、宗孝紀、星野友昭、石井直人
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター、北海道札幌市
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] Hepatocyte growth factor-regulated tyrosine kinase substrate is required for T cell development and survival2015

    • Author(s)
      鈴木信、村田和子、奥山祐子、浅尾敦子、宗孝紀、田中伸幸、石井直人
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター、北海道札幌市
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] Oral classical dendritic cells induce sublingual antigen-specific regulatory T cells in draining lumph nodes2015

    • Author(s)
      田中志典、長島宏行、石井直人、菅原俊二
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター、北海道札幌市
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-15H04742
  • [Presentation] Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques2014

    • Author(s)
      藤田剛、石井直人、Ndhlovu LC
    • Organizer
      32nd Nonhuman Primate Models for AIDS
    • Place of Presentation
      USA, Portland
    • Year and Date
      2014-11-13
    • Data Source
      KAKENHI-PROJECT-24390118
  • [Presentation] TRAF5はIL-6シグナルを制御することでTh17分化を抑制する2014

    • Author(s)
      長島宏行、奥山祐子、浅尾敦子、河部剛史、山木聡史、中野裕康、Michael Croft、石井直人、宗孝紀
    • Organizer
      第68回日本細菌学会東北支部総会
    • Place of Presentation
      仙台市・片平さくホール
    • Year and Date
      2014-08-23
    • Data Source
      KAKENHI-PROJECT-24390118
  • [Presentation] Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques2014

    • Author(s)
      藤田剛、石井直人、Ndhlovu LC
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都市・国立京都国際会館
    • Year and Date
      2014-11-10
    • Data Source
      KAKENHI-PROJECT-24390118
  • [Presentation] TNF receptor-associated factor 5 inhibits Th17 differentiation by antagonizong IL-6-receptor signaling2014

    • Author(s)
      長島宏行、石井直人、宗孝紀
    • Organizer
      The 2nd symposium of international immunological memory and vaccine forum
    • Place of Presentation
      USA, San Diego
    • Year and Date
      2014-08-25
    • Data Source
      KAKENHI-PROJECT-24390118
  • [Presentation] OX40 and IL-7 play synergistic roles in the homeostatic proliferation of effector memory CD4+ T cells2014

    • Author(s)
      奥山祐子、山木聡史、河部剛史、石井直人
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都市・国立京都国際会館
    • Year and Date
      2014-12-10
    • Data Source
      KAKENHI-PROJECT-24390118
  • [Presentation] マクロファージ機能におけるL-アルギニンの効果2014

    • Author(s)
      浅尾敦子、宗孝紀、Ndhlovu LC、浅尾裕信、菅村和夫、石井直人
    • Organizer
      第68回日本細菌学会東北支部総会
    • Place of Presentation
      仙台市・片平さくホール
    • Year and Date
      2014-08-23
    • Data Source
      KAKENHI-PROJECT-24390118
  • [Presentation] Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques2014

    • Author(s)
      藤田剛、石井直人、Ndhlovu LC
    • Organizer
      NIH-Japan-JSPS symposium 2014
    • Place of Presentation
      USA, Bethesda
    • Year and Date
      2014-10-24
    • Data Source
      KAKENHI-PROJECT-24390118
  • [Presentation] A novel molecular function of TRAF5 in CD4 T cell lineage commitment2014

    • Author(s)
      宗孝紀、石井直人
    • Organizer
      The 2nd symposium of international immunological memory and vaccine forum
    • Place of Presentation
      USA, San Diego
    • Year and Date
      2014-08-25
    • Data Source
      KAKENHI-PROJECT-24390118
  • [Presentation] TRAF5 controls of Th17 development by antagonizing IL-6-receptor signaling2014

    • Author(s)
      長島宏行、石井直人、宗孝紀
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都市・国立京都国際会館
    • Year and Date
      2014-11-10
    • Data Source
      KAKENHI-PROJECT-24390118
  • [Presentation] Tim-3を標的とした動物モデルの開発2014

    • Author(s)
      藤田剛、石井直人、Ndhlovu LC
    • Organizer
      第68回日本細菌学会東北支部総会
    • Place of Presentation
      仙台市・片平さくホール
    • Year and Date
      2014-08-23
    • Data Source
      KAKENHI-PROJECT-24390118
  • [Presentation] 腸管Th17細胞の産生における腸間膜リンパ節の役割2013

    • Author(s)
      河部剛史、孫舒嵐、鈴木信、山木聡史、浅尾敦子、宗孝紀、石井直人
    • Organizer
      第67回日本細菌学会東北支部総会
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-24659487
  • [Presentation] TRAF5 controls inflammatory CD4 T cells in experimental autoimmune encephalomyelitis2013

    • Author(s)
      Nagashima H, Yamaki S, Asao A, Croft M, Ishii N, So T
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉市
    • Data Source
      KAKENHI-PROJECT-24590571
  • [Presentation] Th17 cell generation and mucosal immunity2013

    • Author(s)
      Takeshi Kawabe, Shu-lan Sun, Satoshi Yamaki, Atsuko Asao, Takeshi Takahashi, Takanori So, and Naoto Ishii
    • Organizer
      Annual International Symposium of Rheumatology Institute of Seoul National University Hospital
    • Place of Presentation
      Seoul
    • Year and Date
      2013-06-28
    • Data Source
      KAKENHI-PROJECT-24659487
  • [Presentation] 脳腫瘍幹細胞モデルに対する共刺激因子CD40免疫治療の開発2013

    • Author(s)
      長南雅志、齋藤竜太、柴原一陽、金森政之、園田順彦、隈部俊宏、渡辺みか、菊池利明、石井直人、冨永悌二
    • Organizer
      第31回日本脳腫瘍学会学術集会
    • Place of Presentation
      宮崎
    • Data Source
      KAKENHI-PROJECT-25670613
  • [Presentation] Y chromosome-linked B and NK cell deficiency in mice2013

    • Author(s)
      Sun SL, Itoh A, Asao A, Takahashi T, So T, Kondo M, Ishii N
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉市
    • Data Source
      KAKENHI-PROJECT-24590571
  • [Presentation] TRAF5欠損マウスでは実験的自己免疫性脳脊髄炎が増悪する2013

    • Author(s)
      長島宏行、山木聡史、浅尾敦子、Michael Croft、石井直人、宗孝紀
    • Organizer
      第67回日本細菌学会東北支部総会
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-24590571
  • [Presentation] Y-Chromosome-linked B- and NK-cell deficiency in mice2013

    • Author(s)
      Shu-lan Sun, Satoshi Horino, Ari Ito, Takeshi Kawabe, Atsuko Asao, Takeshi Takahashi, Takanori So, Motonari Kondo, and Naoto Ishii
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milano, Italy
    • Data Source
      KAKENHI-PROJECT-24659487
  • [Presentation] Homeostatic proliferation of naïve CD4 T cells in mesenteric lymph nodes generates gut-tropic Th17 cells2013

    • Author(s)
      Takeshi Kawabe, Shu-lan Sun, Satoshi Yamaki, Atsuko Asao, Takeshi Takahashi, Takanori So, and Naoto Ishii
    • Organizer
      NIH-Tohoku University-JSPS Symposium
    • Place of Presentation
      Sendai
    • Data Source
      KAKENHI-PROJECT-24659487
  • [Presentation] 腸管Th17細胞の産生における腸間膜リンパ節の役割2013

    • Author(s)
      河部剛史、孫舒嵐、鈴木信、山木聡史、浅尾敦子、宗孝紀、石井直人
    • Organizer
      第67回日本細菌学会東北支部総会
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-24590571
  • [Presentation] Y chromosome-linked B and NK cell deficiency in mice2013

    • Author(s)
      Sun SL, Itoh A, Asao A, Takahashi T, So T, Kondo M, Ishii N.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉市
    • Data Source
      KAKENHI-PROJECT-24659487
  • [Presentation] TRAF5 controls inflammatory CD4 T cells in experimental autoimmune encephalomyelitis2013

    • Author(s)
      Nagashima H, Yamaki S, Asao A, Croft M, Ishii N, So T.
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉市
    • Data Source
      KAKENHI-PROJECT-24659487
  • [Presentation] Homeostatic proliferation of naïve CD4 T cells in mesenteric lymph nodes generates gut-tropic Th17 cells2013

    • Author(s)
      Takeshi Kawabe, Shu-lan Sun, Satoshi Yamaki, Atsuko Asao, Takeshi Takahashi, Takanori So, and Naoto Ishii
    • Organizer
      The 1st Symposium of International Immunological Memory and Vaccine Forum
    • Place of Presentation
      東京
    • Year and Date
      2013-01-29
    • Data Source
      KAKENHI-PROJECT-24659487
  • [Presentation] Homeostatic proliferation of naïve CD4 T cells in mesenteric lymph nodes generates gut-tropic Th17 cells2013

    • Author(s)
      Takeshi Kawabe, Shu-lan Sun, Satoshi Yamaki, Atsuko Asao, Takeshi Takahashi, Takanori So, and Naoto Ishii
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      Milano, Italy
    • Data Source
      KAKENHI-PROJECT-24659487
  • [Presentation] TRAF5欠損マウスでは実験的自己免疫性脳脊髄炎が増悪する2013

    • Author(s)
      長島宏行、山木聡史、浅尾敦子、Michael Croft、石井直人、宗孝紀
    • Organizer
      第67回日本細菌学会東北支部総会
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-24659487
  • [Presentation] TNF receptor-associated factor 5 によるヘルパーT細胞制御機構の解明2012

    • Author(s)
      長島宏行、山木聡史、Michael Croft、石井直人、宗孝紀
    • Organizer
      第66回日本細菌学会東北支部総会
    • Place of Presentation
      東北大学 片平さくらホール
    • Data Source
      KAKENHI-PROJECT-24590571
  • [Presentation] TNF receptor-associated factor 5 inhibits Th17 and Tfh differentiation2012

    • Author(s)
      Hiroyuki Nagashima, Satoshi Yamaki, Michael Croft, Naoto Ishii, Takanori So
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-24590571
  • [Presentation] TNF receptor-associated factor 5 inhibits Th17 and Tfh differentiation2012

    • Author(s)
      Nagashima H, Yamaki S, Croft M, Ishii N, So T.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-24659487
  • [Presentation] リーシュマニア原虫感染防御におけるL-アルギニンの効果2012

    • Author(s)
      浅尾敦子、宗孝紀、Lishomwa C. Ndhlovu、浅尾裕信、菅村和夫、石井直人
    • Organizer
      第66回日本細菌学会東北支部総会
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-24659487
  • [Presentation] L-arginine upregulates NO production by macrophages during infection with Leishmania major2012

    • Author(s)
      Asao A, So T, Hoshino T, Asao H, Sugmura K, Ishii N.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-24659487
  • [Presentation] Homeostatic proliferation occurs in mesenteric lymph nodes and supplies effector memory CD4^+ T cells in the intestine2012

    • Author(s)
      Kawabe T, Sun SL, Yamaki S, Asao A, Takahashi T, So T, Ishii N.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-24659487
  • [Presentation] TNF receptor-associated factor 5によるヘルパーT細胞制御機構の解明2012

    • Author(s)
      長島宏行、山木聡史、Michael Croft、石井直人、宗孝紀
    • Organizer
      第66回日本細菌学会東北支部総会
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-24659487
  • [Presentation] OX40 contributes to the generation and maintenance of memory CD4+ T cells2011

    • Author(s)
      Ishii N
    • Organizer
      40th JSI international symposium
    • Place of Presentation
      Chiba
    • Data Source
      KAKENHI-PROJECT-21390114
  • [Presentation] OX40 contributes to the generation and maintenance of memory CD4+ T cells2011

    • Author(s)
      Ishii N.
    • Organizer
      第40回日本免疫学会学術集会国際シンポジウム
    • Place of Presentation
      千葉市
    • Year and Date
      2011-11-29
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Presentation] OX40 contributes to the generation and maintenance of memory CD4+T cells2011

    • Author(s)
      Ishii N
    • Organizer
      第40回日本免疫学会学術集会・国際シンポジウム
    • Place of Presentation
      千葉市
    • Year and Date
      2011-11-29
    • Data Source
      KAKENHI-PROJECT-21390114
  • [Presentation] The analysis of the functions of human T cells in humanized NOD/shi-scid/gamma cnull (NOG)-HLA transgenic mice2010

    • Author(s)
      Takahashi T, Suzuki M, Katano I, Ito R, Ishii N, Ito M, and Sugamura K.
    • Organizer
      14th International Congress of Immunology (ICI2010)
    • Place of Presentation
      Kobe, Japan
    • Data Source
      KAKENHI-PROJECT-21390114
  • [Presentation] Positional identification of TNFRSF14, encoding the herpes virus entry mediator, as a susceptibility gene for inflammatory bowel disease in mice2010

    • Author(s)
      Kawabe T, Irie M, Ono M, Asao A, Zhang M, Yoshida A, Takahashi T, Uede T, Watanabe N, Sugamura K, and Ishii N.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Data Source
      KAKENHI-PROJECT-21390114
  • [Presentation] OX40-Mediated Susceptibility to Leishmania major Infection is Dependent on IL-132010

    • Author(s)
      Asao A, Ndhlovu LC, Hoshino T, Sugamura K, and Ishii N.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Data Source
      KAKENHI-PROJECT-21390114
  • [Presentation]2009

    • Author(s)
      Asao A, Sugamura K, and Ishii N
    • Organizer
      3rd NM-GCOE international symposium
    • Place of Presentation
      Sendai
    • Data Source
      KAKENHI-PROJECT-21390114
  • [Presentation] Roles of OX40 in the generation and maintenance of memory T cells2009

    • Author(s)
      Naoto Ishii
    • Organizer
      1^<st> International CSI/JSI/KAI Joint Symposium on Immunology
    • Place of Presentation
      Shanghai, China
    • Data Source
      KAKENHI-PROJECT-21390114
  • [Presentation] Roles of OX40 in the generation and maintenance of memory T cells2009

    • Author(s)
      Naoto Ishii
    • Organizer
      3rd NM-GCOE international symposium
    • Place of Presentation
      Sendai
    • Data Source
      KAKENHI-PROJECT-21390114
  • [Presentation] Roles of OX40 in the generation and maintenance of memory T cells2009

    • Author(s)
      Naoto Ishii
    • Organizer
      The first CSI/JSI/KAI joint symposium on Immunology
    • Place of Presentation
      Shanghai, China
    • Data Source
      KAKENHI-PROJECT-21390114
  • [Presentation] Facilitating the human B cell development in humanized-NOG mice2008

    • Author(s)
      渡邊庸平、高橋武司、石井直人、土屋滋、菅村和夫
    • Organizer
      2008日本免疫学会総会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-19390280
  • [Presentation] Differential roles for OX40 and IL-7 on homeostasis of effector mem ory CD4^+ T cells2008

    • Author(s)
      Ishii N. et.al.
    • Organizer
      Experimental Biology 2008
    • Place of Presentation
      San Diego, U.S.A
    • Year and Date
      2008-04-08
    • Data Source
      KAKENHI-PROJECT-19044005
  • [Presentation] Differential roles for OX40 and IL-7 on homeostasis of effector memory CD4^+ T cells2008

    • Author(s)
      Ishii N., et.al.
    • Organizer
      Experimental Biology 2008
    • Place of Presentation
      San Diego, U.S.A
    • Year and Date
      2008-04-08
    • Data Source
      KAKENHI-PROJECT-20659058
  • [Presentation] Inflammatory bowel disease mediated by OX40 signaling2006

    • Author(s)
      Ishii, N
    • Organizer
      36^<th> Annual meeting of JSI
    • Place of Presentation
      Osaka
    • Year and Date
      2006-12-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390148
  • [Presentation] Inflammatory bowel disease mediated by OX40 signaling2006

    • Author(s)
      Ishii N.
    • Organizer
      第36回日本免疫学会
    • Place of Presentation
      大阪
    • Year and Date
      2006-12-13
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390148
  • [Presentation] TNF receptor-associated factor 5 inhibits Th17 differentiation by antagonizong IL-6-receptor signaling

    • Author(s)
      Nagashima H, Okuyama Y, Asao A, Kawabe T, Yamaki S, Nakano H, Croft M, Ishii N, and So T
    • Organizer
      The 2nd symposium of international immunological memory and vaccine forum
    • Place of Presentation
      La Jolla Institute for Allergy & Immunology, La Jolla, CA, USA
    • Year and Date
      2014-08-25 – 2014-08-26
    • Data Source
      KAKENHI-PROJECT-24590571
  • [Presentation] TRAF5 controls Th17 development by antagonizing IL-6-receptor signaling

    • Author(s)
      Nagashima H, Okuyama Y, Asao A, Kawabe T, Yamaki S, Nakano H, Croft M, Ishii N, and So T
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都国際会議場(京都市)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-24590571
  • [Presentation] OX40 and IL-7 play synergistic roles in the homeostatic proliferation of effector memory CD4+ T cells

    • Author(s)
      Okuyama Y, Yamaki S, Ine S, Kawabe T, Suzuki N, Nagashima H, Sun SL, So T, Sugamura K, Ishii N
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都国際会議場(京都市)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-24590571
  • [Presentation] TRAF5はIL-6シグナルを制御することでTh17分化を抑制する

    • Author(s)
      長島宏行、奥山祐子、浅尾敦子、河部剛史、山木聡史、中野裕康、Michael Croft、石井直人、宗孝紀
    • Organizer
      第68回日本細菌学会東北支部総会
    • Place of Presentation
      東北大学片平さくらホール(仙台市)
    • Year and Date
      2014-08-22 – 2014-08-23
    • Data Source
      KAKENHI-PROJECT-24590571
  • []

  • 1.  SO Takanori (60294964)
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  • 2.  ASAO Hironobu (80250744)
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  • 3.  SUGAMURA Kazuo (20117360)
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  • 4.  TANAKA Nobuyuki (60280872)
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  • 5.  ONO Masao (20302218)
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  • 6.  TAKESHITA Toshokazu (60212023)
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  • 7.  Kawabe Takeshi (50834652)
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  • 8.  KINOUCHI Yoshitaka (20250780)
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  • 9.  KIKUCHI Toshiaki (10280926)
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  • 10.  MURATA Kazuko (20137631)
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  • 11.  Okuyama Yuko (50624475)
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  • 12.  YAMAMOTO Kazuhiko (80191394)
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  • 13.  TSUCHIYA Shigeru (30124605)
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  • 18.  TAKAHASHI Kazuma (60292215)
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  • 19.  YOSHINORI Hinokio (10282071)
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  • 20.  TAKAHASHI Takeshi (80335215)
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  • 21.  SUGAWARA Shunji (10241639)
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  • 23.  Oshitani Hitoshi (80419994)
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  • 24.  Kikuchi Atsuo (30447156)
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  • 25.  下川 宏明 (00235681)
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  • 26.  星川 康 (90333814)
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  • 27.  新妻 秀剛 (30392252)
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  • 28.  久間木 悟 (20311566)
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  • 29.  笹原 洋二 (60372314)
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  • 30.  森田 英嗣 (70344653)
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  • 31.  NDHLOVU Lishmowa C (10374935)
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  • 32.  黒石 智誠 (30400261)
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  • 33.  斉藤 繭子 (20598031)
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  • 34.  神垣 太郎 (80451524)
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  • 35.  玉記 雷太 (40507919)
    # of Collaborated Projects: 1 results
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  • 36.  守田 雅志 (20191033)
    # of Collaborated Projects: 1 results
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  • 37.  川口 甲介 (80624866)
    # of Collaborated Projects: 1 results
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  • 38.  守田 匡伸 (10519094)
    # of Collaborated Projects: 1 results
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  • 39.  浅尾 敦子 (10623605)
    # of Collaborated Projects: 1 results
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  • 40.  NAGASHIMA Hiroyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  LU Lu
    # of Collaborated Projects: 1 results
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  • 42.  SHISHIDO Kaori
    # of Collaborated Projects: 1 results
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  • 43.  Okamoto Michiko
    # of Collaborated Projects: 1 results
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  • 44.  Saito Mariko
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  • 45.  Furuse Yuki
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  • 46.  Otomaru Hirono
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  • 47.  Ueno Fumihiko
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  • 48.  Clyde Dapat
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  • 50.  TALLO Veronica
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  • 51.  ALDAY Portia P.
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  • 52.  MERCADO Edelwisa S.
    # of Collaborated Projects: 1 results
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  • 53.  Sirjan Bastola
    # of Collaborated Projects: 1 results
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  • 54.  Malasao Rungnapa
    # of Collaborated Projects: 1 results
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  • 55.  Alexander Burmaa
    # of Collaborated Projects: 1 results
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  • 56.  Od Isn
    # of Collaborated Projects: 1 results
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  • 57.  MIZUASHI Masato
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  • 58.  NIIHORI Tetsuya
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  • 59.  YAMAMOTO YUI
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  • 60.  KAI Katsunori
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  • 61.  MATSUMOTO Mitsuyo
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  • 62.  SATO masaki
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  • 63.  IGARASHI kazuhiko
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  • 64.  山崎 研志
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  • 65.  富田 博秋
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  • 66.  兪 志前
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  • 67.  中司 寛子
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  • 68.  岡田 随象
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  • 69.  峯岸 正好
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  • 70.  高橋 和真
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  • 71.  青木 洋子
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  • 72.  阿部 太紀
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  • 73.  松尾 理
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  • 74.  岡田 清孝
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  • 75.  大和田 祐二
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  • 76.  塚口 裕康
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  • 77.  岩倉 洋一郎
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  • 78.  田澤 立之
    # of Collaborated Projects: 0 results
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  • 79.  中田 光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 80.  松嵜 葉子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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