Aki Toshihiko 秋利彦

… Alternative Names

AKI Toshihiko 秋利彦

Less

Researcher Number	60304474
Other IDs
Affiliation (Current)	2025: 東京科学大学, 大学院医歯学総合研究科, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2023: 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 2015: 東京医科歯科大学, 大学院医歯学総合研究科, 講師 2012 – 2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 2010 – 2012: 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 2004 – 2005: 山口大学, 総合科学実験センター, 助手 2003: 山口大, 医学部, 助手 1998 – 2000: 山口大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Legal medicine / Basic Section 58040:Forensics medicine-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Legal medicine Except Principal Investigator Legal medicine / Basic Section 58040:Forensics medicine-related / Legal medicine / 細胞死(アポトーシス)
Keywords	Principal Investigator 細胞死 / ミトコンドリア / プロテオミクス / ヒ素 / パイロトーシス / アポトーシス / コカイン / オートファジー / プロテオーム / 法医学 … More / 解糖系 / 肝障害 / 肝臓 / 酸化ストレス / カタラーゼ / 代謝物 / 代謝産物 / 免疫細胞 / 炎症 / グルコース / 炎症性細胞死 / アセトアミノフェン / ガスダーミン / 代謝 / マクロファージ / フェロトーシス / 化学物質 / ネクローシス / 法医病理 / ヘム / タンパク質凝集体 / メタボロミクス / 硫化水素 / p62 / フィブロネクチン / CORM-3 / 一酸化炭素 / 心筋障害 / 肺線維症 / 中毒学 / パラコート / 薬毒物 / トランスクリプトミクス / アルコール / 細胞障害 / マクロピノサイトース / 覚せい剤 / GAPDH / 低酸素 / 虚血 / 心筋 … More Except Principal Investigator アポトーシス / ヒ素 / メタボロミクス / 細胞毒性 / メタボローム解析 / PKC / apoptosis / 亜ヒ酸 / 再潅流 / プロテアソーム / 心筋梗塞 / 虚血 / 神経細胞死 / ネクローシス / パイロトーシス / 細胞老化 / 酸化ストレス / ヒト肝がん細胞Huh-7 / ストレス顆粒 / フェロトーシス / ネクロトーシス / 神経細胞 / メタボローム / 細胞死 / オートファジー / ラット / 三酸化二ヒ素 / ATR-Chk経路 / PML / 脳 / membrane / GPR30 / Estrogen / リガンド探索 / プロテオーム / がん / 心臓 / オーファン受容体 / early immediate genes / MAP kinase / myocardial infarction / stress / reperfusion / ischemia / 細胞内情報伝達 / 心筋障害 / MAP キナーゼ / 虚血再灌流 / プロテインキナーゼC / 早期反応遺伝子 / MAPキナーゼ / ストレス / ubiquitin-proteasome系 / 心筋由来細胞 / ユビキチン－プロテアソーム系 / Parkin / ユビキチンプロテアソーム系 / 心筋 / ユビキチン-プロテアソーム系 / ネクシン43 / 突然死 / 不整脈 / カルパイン / 免疫組織 / コネクシン43 Less

ヒ素肝毒性の分子機構Principal Investigator
- Principal Investigator
  
  秋利彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58040:Forensics medicine-related
- Research Institution
  Tokyo Medical and Dental University
Regulation mechanism of pyroptosis by metabolitesPrincipal Investigator
- Principal Investigator
  
  Aki Toshihiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58040:Forensics medicine-related
- Research Institution
  Tokyo Medical and Dental University
Neuronal death induced by arsenic --- Participation of necroptosis and ferroptosis
- Principal Investigator
  
  UEMURA KOICHI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58040:Forensics medicine-related
- Research Institution
  Tokyo Medical and Dental University
Construction of a method for analyzing the toxic mechanism and new toxic markers by metabolome analysis
- Principal Investigator
  
  Funakoshi Takeshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58040:Forensics medicine-related
- Research Institution
  Tokyo Medical and Dental University
Cell death by chemicals and possible involvement of regulated necrosisPrincipal Investigator
- Principal Investigator
  
  Aki Toshihiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Tokyo Medical and Dental University
Analysis of carbon monoxide toxicity using water-soluble CORMsPrincipal Investigator
- Principal Investigator
  
  Aki Toshihiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Legal medicine
- Research Institution
  Tokyo Medical and Dental University
Cell death induced by arsenite in relation to autophasy and proteasome system
- Principal Investigator
  
  UEMURA Koichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Tokyo Medical and Dental University
Analysis of drug toxicity mechanism and toxicity evaluation method using targeted metabolome method
- Principal Investigator
  
  Funakoshi Takeshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Tokyo Medical and Dental University
Molecular analysis of drug intoxication by use of integrated toxicomicsPrincipal Investigator
- Principal Investigator
  
  Aki Toshihiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Tokyo Medical and Dental University
Molecular biochemical studies on the mechanisms of arsenite-induced intoxication
- Principal Investigator
  
  Uemura koichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Tokyo Medical and Dental University
Proteomic screening of possible marker proteins for drug-induced cellular injuriesPrincipal Investigator
- Principal Investigator
  
  AKI Toshihiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Tokyo Medical and Dental University
Screening of a ligand for hypoxia-induced receptor by negative selection method
- Principal Investigator
  
  MIZUKAMI Yoichi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  細胞死(アポトーシス)
- Research Institution
  Yamaguchi University
心筋虚血細胞死におけるオートファジー様細胞死の関与Principal Investigator
- Principal Investigator
  
  秋利彦
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Legal medicine
- Research Institution
  Yamaguchi University
虚血心筋におけるGAPDH遺伝子発現の分子機構と細胞死(アポトーシス)誘導機序Principal Investigator
- Principal Investigator
  
  秋利彦
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Legal medicine
- Research Institution
  Yamaguchi University
心筋梗塞化におけるコネクシン43分解の病態生理学的研究と早期梗塞診断の開発
- Principal Investigator
  
  YOSHIDA Ken-ichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Legal medicine
- Research Institution
  The University of Tokyo
FORENSIC PATHOLOGICAL STUDY ON PROTEINS AND GENES INDUCED BY STRESS OR ISCHEMIA
- Principal Investigator
  
  YOSHIDA Ken-ichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Legal medicine
- Research Institution
  The University of Tokyo
  Yamaguchi University

[Book] Autophagy in health and disease2018
- Author(s)
  Toshihiko Aki, Kanako Noritake, Kana Unuma, Koichi Uemura
- Total Pages
  18
- Publisher
  Humana press
- ISBN
  9783319981451
- Data Source
  KAKENHI-PROJECT-17H04147
[Book] Comprehensive Toxicology 3rd ed Volume 1 (General subjects).2018
- Author(s)
  Toshihiko Aki, Kanako Noritake, Takeshi Funakoshi, Koichi Uemura.
- Total Pages
  25
- Publisher
  Elsevier
- ISBN
  9780081006016
- Data Source
  KAKENHI-PROJECT-17H04147
[Book] Regulation of Cardiomyocyte functions by distinct phosphoinositide 3-kinase, "Molecular Mechanisms of Heart diseases"(Edits Mizukami, Y., Ohkusa, T.)2005
- Author(s)
  Aki, T., Mizukami, Y.
- Publisher
  Publisher Research Signpoet
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16601002
[Book] Orphan G protein-coupled receptor and ischemia, "Molecular Mechanisms of Heart diseases"(Edits Mizukami, Y., Ohkusa, T.)2005
- Author(s)
  Kimura, Y, Mizukami, Y., Matsuzaki, M.
- Publisher
  Publisher Research Signpoet
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16601002
[Journal Article] Increased fatty acid synthesis and disturbed lipid metabolism in Neuro2a cells after repeated cocaine exposure: A preliminary study2024
- Author(s)
  Nomura Moeka、Wen Shuheng、Unuma Kana、Funakoshi Takeshi、Aki Toshihiko、Uemura Koichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 695 Pages: 149438-149438
- DOI
  10.1016/j.bbrc.2023.149438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K09760
[Journal Article] Ectopic myogenesis and fibrosis accompany adipogenesis during thymic involution induced by repeated cocaine administration2023
- Author(s)
  Unuma Kana、Wen Shuheng、Aki Toshihiko、Uemura Koichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 686 Pages: 149201-149201
- DOI
  10.1016/j.bbrc.2023.149201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K10606, KAKENHI-PROJECT-23K09760
[Journal Article] Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells2023
- Author(s)
  Komatsu M, Funakoshi T, Aki T, Unuma K, Uemura K.
- Journal Title
  
  Toxicology letters
  
  Volume: 378 Pages: 39-50
- DOI
  10.1016/j.toxlet.2023.02.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K10605, KAKENHI-PROJECT-20H03955, KAKENHI-PROJECT-23K09760
[Journal Article] Cocaine induces vascular smooth muscle cells proliferation via DRP1-mediated mitochondrial fission and PI3K/HIF-1α signaling2023
- Author(s)
  Wen Shuheng、Unuma Kana、Funakoshi Takeshi、Aki Toshihiko、Uemura Koichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 676 Pages: 30-35
- DOI
  10.1016/j.bbrc.2023.07.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10606, KAKENHI-PROJECT-23K09760, KAKENHI-PROJECT-23K19799
[Journal Article] Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells2023
- Author(s)
  Aki Toshihiko、Tanaka Hiroki、Funakoshi Takeshi、Unuma Kana、Uemura Koichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 676 Pages: 66-72
- DOI
  10.1016/j.bbrc.2023.07.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K09760
[Journal Article] Induction of filamin-C and its involvement in the regulation of cellular senescence and apoptosis in Huh-7 hepatoma cells during arsenic trioxide exposure2023
- Author(s)
  Aki Toshihiko、Kukita Mitsuki、Takata Mao、Funakoshi Takeshi、Unuma Kana、Uemura Koichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 651 Pages: 92-97
- DOI
  10.1016/j.bbrc.2023.02.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03955, KAKENHI-PROJECT-23K09760
[Journal Article] Inverse regulation of GSDMD and GSDME gene expression during LPS-induced pyroptosis in RAW264.7 macrophage cells2022
- Author(s)
  Aki Toshihiko、Funakoshi Takeshi、Unuma Kana、Uemura Koichi
- Journal Title
  
  Apoptosis
  
  Volume: 27 Issue: 1-2 Pages: 14-21
- DOI
  10.1007/s10495-022-01708-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03955
[Journal Article] The Role of Peroxiredoxins in the Regulation of Sepsis2022
- Author(s)
  Aki Toshihiko、Unuma Kana、Uemura Koichi
- Journal Title
  
  Antioxidants
  
  Volume: 11 Issue: 1 Pages: 126-126
- DOI
  10.3390/antiox11010126
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03955, KAKENHI-PROJECT-22K10606
[Journal Article] Thymic involution caused by repeated cocaine administration includes apoptotic cell loss followed by ectopic adipogenesis2022
- Author(s)
  Unuma Kana、Kaga Homare、Funakoshi Takeshi、Nomura Moeka、Aki Toshihiko、Uemura Koichi
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 11 Pages: e0277032-e0277032
- DOI
  10.1371/journal.pone.0277032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10606, KAKENHI-PROJECT-20H03955
[Journal Article] Contraction Band Necrosis with Dephosphorylated Connexin 43 in Rat Myocardium after Daily Cocaine Administration2022
- Author(s)
  Wen Shuheng、Unuma Kana、Funakoshi Takeshi、Aki Toshihiko、Uemura Koichi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 19 Pages: 11978-11978
- DOI
  10.3390/ijms231911978
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10606, KAKENHI-PROJECT-20H03955
[Journal Article] Aggregation-prone A53T mutant of α-synuclein exaggerates methamphetamine neurotoxicity in SH-SY5Y cells: Protective role of cellular cholesterol2022
- Author(s)
  Aoki Sho、Funakoshi Takeshi、Aki Toshihiko、Uemura Koichi
- Journal Title
  
  Toxicology Reports
  
  Volume: 9 Pages: 2020-2029
- DOI
  10.1016/j.toxrep.2022.11.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03955
[Journal Article] Cell Death and Survival Pathways Involving ATM Protein Kinase2021
- Author(s)
  Aki Toshihiko、Uemura Koichi
- Journal Title
  
  Genes
  
  Volume: 12 Issue: 10 Pages: 1581-1581
- DOI
  10.3390/genes12101581
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03955
[Journal Article] Altered cardiac mitochondrial dynamics and biogenesis in rat after short-term cocaine administration2021
- Author(s)
  Wen Shuheng、Unuma Kana、Funakoshi Takeshi、Aki Toshihiko、Uemura Koichi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 24129-24129
- DOI
  10.1038/s41598-021-03631-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10680, KAKENHI-PROJECT-20H03955
[Journal Article] Oxcarbazepine induces mitotic catastrophe and apoptosis in NRK-52E proximal tubular cells2021
- Author(s)
  Ota Momoka、Funakoshi Takeshi、Aki Toshihiko、Unuma Kana、Uemura Koichi
- Journal Title
  
  Toxicology Letters
  
  Volume: 350 Pages: 240-248
- DOI
  10.1016/j.toxlet.2021.07.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10680, KAKENHI-PROJECT-19K10682
[Journal Article] Possible roles of AMPK and macropinocytosis in the defense responses against Δ9-THC toxicity on HL-1 cardiomyocytes2021
- Author(s)
  Murata Tatsuhiko、Noritake Kanako、Aki Toshihiko、Uemura Koichi
- Journal Title
  
  Toxicology Reports
  
  Volume: 8 Pages: 980-987
- DOI
  10.1016/j.toxrep.2021.04.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19670, KAKENHI-PROJECT-19K19483
[Journal Article] Pyroptotic cell death by exposure to 1-butanol in H9c2 cardiomyoblastoma cells2020
- Author(s)
  Kanako Noritake , Toshihiko Aki , Shintaro Isa , Koichi Uemura
- Journal Title
  
  Heliyon
  
  Volume: 6 Issue: 11 Pages: e05503-e05503
- DOI
  10.1016/j.heliyon.2020.e05503
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K19483, KAKENHI-PROJECT-18K19670
[Journal Article] Chemically Induced Models of Parkinson’s Disease: History and Perspectives for the Involvement of Ferroptosis2020
- Author(s)
  Wen Shuheng、Aki Toshihiko、Unuma Kana、Uemura Koichi
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 14 Pages: 581191-581191
- DOI
  10.3389/fncel.2020.581191
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19670
[Journal Article] Extracellular glucose is crucially involved in the fate decision of LPS-stimulated RAW264.7 murine macrophage cells2020
- Author(s)
  Aki Toshihiko、Funakoshi Takeshi、Noritake Kanako、Unuma Kana、Uemura Koichi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 10581-10581
- DOI
  10.1038/s41598-020-67396-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03955, KAKENHI-PROJECT-18K19670
[Journal Article] Formation of high molecular weight p62 by CORM-32019
- Author(s)
  Aki Toshihiko、Unuma Kana、Noritake Kanako、Hirayama Naho、Funakoshi Takeshi、Uemura Koichi
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 1 Pages: e0210474-e0210474
- DOI
  10.1371/journal.pone.0210474
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04147, KAKENHI-PROJECT-16K09203
[Journal Article] Hydrogen sulfide donor NaHS causes bronchitis with enhanced respiratory secretion in rats2019
- Author(s)
  Unuma Kana、Aki Toshihiko、Yamashita Ayaka、Yoshikawa Ayaka、Uemura Koichi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 44 Issue: 2 Pages: 107-112
- DOI
  10.2131/jts.44.107
- NAID
  130007590450
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04147, KAKENHI-PROJECT-16K09203, KAKENHI-PROJECT-19K10680
[Journal Article] Increased circulating peroxiredoxin-4 in sepsis model rats involves secretion from hepatocytes and is mitigated by GYY41372019
- Author(s)
  Unuma Kana、Yoshikawa Ayaka、Aki Toshihiko、Uemura Koichi
- Journal Title
  
  Journal of Toxicologic Pathology
  
  Volume: 32 Issue: 4 Pages: 305-310
- DOI
  10.1293/tox.2019-0030
- NAID
  130007731846
- ISSN
  0914-9198, 1881-915X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10680, KAKENHI-PROJECT-18K19670, KAKENHI-PROJECT-17H04147
[Journal Article] Repeated exposure of cocaine alters mitochondrial dynamics in mouse neuroblastoma Neuro2a2019
- Author(s)
  Funakoshi Takeshi、Furukawa Mako、Aki Toshihiko、Uemura Koichi
- Journal Title
  
  NeuroToxicology
  
  Volume: 75 Pages: 70-77
- DOI
  10.1016/j.neuro.2019.09.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10682, KAKENHI-PROJECT-18K19670
[Journal Article] The down-regulation of cardiac contractile proteins underlies myocardial depression during sepsis and is mitigated by carbon monoxide2018
- Author(s)
  Unuma Kana、Aki Toshihiko、Nagano Suguru、Watanabe Ryo、Uemura Koichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 2 Pages: 1668-1674
- DOI
  10.1016/j.bbrc.2017.12.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04147, KAKENHI-PROJECT-16K09203
[Journal Article] Necrosis in human neuronal cells exposed to paraquat2018
- Author(s)
  Naho Hirayama, Toshihiko Aki, Takeshi Funakoshi, Kanako Noritake, Kana Unuma, Koichi Uemura.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 43 Issue: 3 Pages: 193-202
- DOI
  10.2131/jts.43.193
- NAID
  130006507321
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04147, KAKENHI-PROJECT-16K09203
[Journal Article] Interaction of carbon monoxide-releasing ruthenium carbonyl CORM-3 with plasma fibronectin2018
- Author(s)
  Aki Toshihiko、Unuma Kana、Noritake Kanako、Kurahashi Hatsumi、Funakoshi Takeshi、Uemura Koichi
- Journal Title
  
  Toxicology in Vitro
  
  Volume: 50 Pages: 201-209
- DOI
  10.1016/j.tiv.2018.03.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04147, KAKENHI-PROJECT-16K09203
[Journal Article] Emerging roles of mitochondria and autophagy in liver injury during sepsis2017
- Author(s)
  Aki Toshihiko、Unuma Kana、Uemura Koichi
- Journal Title
  
  Cell Stress
  
  Volume: 1 Issue: 2 Pages: 79-89
- DOI
  10.15698/cst2017.11.110
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09203, KAKENHI-PROJECT-17H04147
[Journal Article] Restoration of YAP activation rescues HL-1 cardiomyocytes from apoptotic death by ethanol2017
- Author(s)
  Kanako Noritake, Toshihiko Aki, Moe Kimura, Takeshi Funakoshi, Kana Unuma, Koichi Uemura.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 42 Issue: 5 Pages: 545-551
- DOI
  10.2131/jts.42.545
- NAID
  130006076729
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15879, KAKENHI-PROJECT-17H04147
[Journal Article] Ataxia telangiectasia and rad3 related (ATR)-promyelocytic leukemia protein (PML) pathway of the DNA damage response in the brain of rats administered arsenic trioxide2017
- Author(s)
  Ryo Watanabe, Kana Unuma, Kanako Noritake, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura.
- Journal Title
  
  Journal of Toxicologic Pathology
  
  Volume: 30 Issue: 4 Pages: 333-337
- DOI
  10.1293/tox.2017-0020
- NAID
  130006176567
- ISSN
  0914-9198, 1881-915X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09201, KAKENHI-PROJECT-16K09203
[Journal Article] Lipopolysaccharide induces expression of collagen VI in the rat lung2015
- Author(s)
  Okawa S, Unuma K, Yamada A, Aki T, Uemura K
- Journal Title
  
  J Toxicol Pathol.
  
  Volume: 28(1) Issue: 1 Pages: 37-41
- DOI
  10.1293/tox.2014-0053
- NAID
  130004842606
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460862, KAKENHI-PROJECT-26713024
[Journal Article] Regulated necrosis and its implications in toxicology2015
- Author(s)
  Aki T, Funakoshi T, Uemura K
- Journal Title
  
  Toxicology
  
  Volume: 333 Pages: 118-126
- DOI
  10.1016/j.tox.2015.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460862
[Journal Article] Direct Exposure to Ethanol Disrupts Junctional Cell-Cell Contact and Hippo-YAP Signaling in HL-1 Murine Atrial Cardiomyocytes.2015
- Author(s)
  Noritake K, Aki T, Funakoshi T, Unuma K, Uemura K.
- Journal Title
  
  PLoS One
  
  Volume: 10(8) Issue: 8 Pages: e0136952-e0136952
- DOI
  10.1371/journal.pone.0136952
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H06182, KAKENHI-PROJECT-25460862, KAKENHI-PROJECT-26713024
[Journal Article] Extrusion of mitochondrial contents from lipopolysaccharide-stimulated cells: Involvement of autophagy.2015
- Author(s)
  Unuma K, Aki T, Funakoshi T, Hashimoto K, Uemura K
- Journal Title
  
  Autophagy
  
  Volume: 11(9) Issue: 9 Pages: 1520-1536
- DOI
  10.1080/15548627.2015.1063765
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460862
[Journal Article] Paraquat induces epithelial-mesenchymal transition-like cellular response resulting in fibrogenesis and the prevention of apoptosis in human pulmonary epithelial cells.2015
- Author(s)
  5.Atsushi Yamada, Toshihiko Aki, Kana Unuma, Takeshi Funakoshi, Koichi Uemura
- Journal Title
  
  PLOSONE
  
  Volume: 10(3) Issue: 3 Pages: e0120192-e0120192
- DOI
  10.1371/journal.pone.0120192
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460862
[Journal Article] Activation of Master Autophagy Regulator TFEB During Systemic LPS Administration in the Cornea2014
- Author(s)
  8.Kyoko Uchida, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, and Koichi Uemura
- Journal Title
  
  Journal of Toxicologic Pathology
  
  Volume: 27 Issue: 2 Pages: 153-158
- DOI
  10.1293/tox.2014-0004
- NAID
  130003391349
- ISSN
  0914-9198, 1881-915X
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460862, KAKENHI-PROJECT-26713024
[Journal Article] Activation of the ubiquitin-proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis.2014
- Author(s)
  Mayumi Watanabe, Takeshi Funakoshi, Kana Unuma, Toshihiko Aki#, and Koichi Uemura
- Journal Title
  
  Toxicology
  
  Volume: 322 Pages: 43-50
- DOI
  10.1016/j.tox.2014.04.008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460862, KAKENHI-PROJECT-25460863, KAKENHI-PROJECT-26713024
[Journal Article] Rho-kinase inhibitor Y-27632 attenuates arsenic trioxide toxicity on H9c2 cardiomyoblastoma cells2013
- Author(s)
  Marie Bessho, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Kanako Noritake, Chizuru Kato, and Koichi Uemura
- Journal Title
  
  Cardiovasc.Toxicol
  
  Volume: (印刷中)
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/23532581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629
[Journal Article] Impairment of autophagy: from hereditary disorder to drug intoxication (Review).2013
- Author(s)
  Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, and Koichi Uemura
- Journal Title
  
  Toxicology
  
  Volume: 311 Issue: 3 Pages: 205-215
- DOI
  10.1016/j.tox.2013.07.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460862
[Journal Article] Inducer of heme oxygenase-1 cobalt protoporphyrin accelerates autophagy and suppresses oxidative damages during LPS treatment inrat liver2013
- Author(s)
  Kana Unuma, Toshihiko Aki, Seiji Matsuda, Takeshi Funakoshi, Ken-ichi Yoshida, Koichi Uemura
- Journal Title
  
  Hepatology Res
  
  Volume: 43 Issue: 1 Pages: 91-96
- DOI
  10.1111/j.1872-034x.2012.01049.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629, KAKENHI-PROJECT-22591637, KAKENHI-PROJECT-24790639
[Journal Article] Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart.2013
- Author(s)
  Hideyuki Maeda, Hisashi Nagai, Genzou Takemura, Masaaki Komatsu, Sayoko Ogura, Kaori Shintani-Ishida, Toshihiko Aki, Mikiyasu Shirai, Ichiro Kuwahira, Ken-ichi Yoshida
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1832 Pages: 1159-1166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460862
[Journal Article] Elimination and active extrusion of livermitochondrial proteins during LPS administration in rat2013
- Author(s)
  Kana Unuma, Toshihiko Aki, Seiji Matsuda, Takeshi Funakoshi, Ken-ichi Yoshida, Koichi Uemura
- Journal Title
  
  Hepatology Res
  
  Volume: 43 Issue: 5 Pages: 526-534
- DOI
  10.1111/j.1872-034x.2012.01084.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629, KAKENHI-PROJECT-22591637, KAKENHI-PROJECT-24790639
[Journal Article] Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart2013
- Author(s)
  Hideyuki Maeda, Hisashi Nagai, GenzouTakemura, Masaaki Komatsu, Sayoko Ogura, Kaori Shintani-Ishida, Toshihiko Aki, Mikiyasu Shirai, Ichiro Kuwahira, Ken-ichi Yoshida
- Journal Title
  
  Biochimicaet Biophysica Acta
  
  Volume: 1832 Issue: 8 Pages: 1159-1166
- DOI
  10.1016/j.bbadis.2013.02.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629, KAKENHI-PROJECT-23249038, KAKENHI-PROJECT-23590843, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-24659334, KAKENHI-PROJECT-24790863, KAKENHI-PROJECT-25293162
[Journal Article] Lysosome vacuolation disrupts the completion of autophagy during norephedrine exposure in SH-SY5Y human neuroblastoma cells2013
- Author(s)
  Takeshi Funakoshi, Toshihiko Aki, Kana Unuma, Koichi Uemura
- Journal Title
  
  Brain Res
  
  Volume: 1490 Pages: 9-22
- DOI
  10.1016/j.brainres.2012.10.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629, KAKENHI-PROJECT-24790639, KAKENHI-PROJECT-25860487
[Journal Article] Cobalt protoporphyrin accelerates TFEBactivation and lysosome reformation during LPS-induced septic insults in rat heart2013
- Author(s)
  Kana Unuma, Toshihiko Aki, Seiji Matsuda, Takeshi Funakoshi, Ken-ichi Yoshida, Koichi Uemura
- Journal Title
  
  PLOS ONE
  
  Volume: e59526 Issue: 2 Pages: 8-8
- DOI
  10.1371/journal.pone.0056526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629, KAKENHI-PROJECT-23249038
[Journal Article] Distinct effects of methamphetamine on autophagy-lysosome and ubiquitin-proteasome systems in HL-1 cultured mouse atrial cardiomyocytes.2013
- Author(s)
  Funakoshi-Hirose I, Aki T, Unuma K, Funakoshi T, Noritake K, Uemura K.
- Journal Title
  
  Toxicology.
  
  Volume: 312(4) Pages: 74-82
- DOI
  10.1016/j.tox.2013.07.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790639, KAKENHI-PROJECT-25460862
[Journal Article] Hyperstimulation of macropinocytosis leads to lysosomal dysfunction and cell death during exposure to methamphetamine in differentiatedSH-SY5Y cells2012
- Author(s)
  Akina Nara, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura
- Journal Title
  
  Brain Res
  
  Volume: 1466 Pages: 1-14
- DOI
  10.1016/j.brainres.2012.05.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629
[Journal Article] Proteomic characterization of the greening process in rice seedlings using the MS spectral intensity-based label free method2012
- Author(s)
  Hamamoto K., Aki T., Shigyo M., Sato S., Ishida T., Yano K., Yoneyama T., and Yanagisawa S.
- Journal Title
  
  Journal of Proteome Resserach
  
  Volume: 11 Issue: 1 Pages: 331-347
- DOI
  10.1021/pr200852q
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380043, KAKENHI-PROJECT-22590629
[Journal Article] Cytoplasmic vacuolization during exposure to drugs and other substances (Review)2012
- Author(s)
  Toshihiko Aki, Akina Nara, and Koichi Uemura
- Journal Title
  
  Cell Biol. and Toxicol
  
  Volume: 28 Pages: 125-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629
[Journal Article] Critical roles of Rho-associated kinase in membrane blebbing and mitochondrial apoptosis caused by 1-butanol2012
- Author(s)
  Kanako Noritake, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Akina Nara, Chizuru Kato, and Koichi Uemura
- Journal Title
  
  Toxicol. inVitro
  
  Volume: 26 Issue: 6 Pages: 849-855
- DOI
  10.1016/j.tiv.2012.04.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629
[Journal Article] Cytoplasmic vacuolization during exposure to drugs and other substances.2012
- Author(s)
  秋　利彦
- Journal Title
  
  Cell Biol Toxicol.
  
  Volume: 28 Issue: 3 Pages: 125-131
- DOI
  10.1007/s10565-012-9212-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629
[Journal Article] Reactive oxygen species-independent rapid initiation of mitochondrial apoptotic pathway bychelerythrine2011
- Author(s)
  Takeshi Funakoshi, Toshihiko Aki, HarukaNakayama, Yumi Watanuki, Satoko Imori,and Koichi Uemura
- Journal Title
  
  Toxicol. in Vitro
  
  Volume: 25 Issue: 8 Pages: 1581-1587
- DOI
  10.1016/j.tiv.2011.05.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629
[Journal Article] Bifurcate effects of glucose on caspase-independent cell death during hypoxia2010
- Author(s)
  Toshihiko Aki, Akina Nara, Takeshi Funakoshi, Koichi Uemura
- Journal Title
  
  Biochem.Biophys. Res. Commun
  
  Volume: 396 Issue: 3 Pages: 614-618
- DOI
  10.1016/j.bbrc.2010.04.122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629
[Journal Article] Methamphetamine induces macropinocytosis in differentiated SH-SY5Y human neuroblastoma cells.2010
- Author(s)
  Akina Nara
- Journal Title
  
  Brain Res.
  
  Volume: 1352 Pages: 1-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629
[Journal Article] Bifurcate effects of glucose on caspase-independent cell death during hypoxia.2010
- Author(s)
  Toshihiko Aki
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 396 Pages: 614-618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629
[Journal Article] Methamphetamine induces macropinocytosis in differentiatedSH-SY5Y human neuroblastoma cells2010
- Author(s)
  Akina Nara, Toshihiko Aki, Takeshi Funakoshi, Koichi Uemura
- Journal Title
  
  Brain Res
  
  Volume: 1352 Pages: 1-10
- DOI
  10.1016/j.brainres.2010.07.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629
[Journal Article] Death due to blood transfusion-induced anaphylactic shock : A case report.2010
- Author(s)
  Akina Nara
- Journal Title
  
  Legal Medicine
  
  Volume: 12 Pages: 148-150
- NAID
  10027575900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590629
[Journal Article] Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinases.2005
- Author(s)
  Tokumitsu H, Hatano N, Inuzuka H, Sueyoshi Y, Yokokura S, Ichimura T, Nozaki N, Kobayashi R.
- Journal Title
  
  J.Biol.Chem. 380(42)
  
  Pages: 35108-35118
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16601002
[Journal Article] Synergistic enhancement of TRIL- and tumor necrosis factor a-induced cell death by a phenoxazine derivative2005
- Author(s)
  Kara, K., Okamoto, M., Aki, T., Yagita, H., Tanaka, H., Mizukami, Y., Nakamura, H., Tomoda, A., Hamasaki, N., Kang, D.
- Journal Title
  
  Mol.Cancer Ther. 4(7)
  
  Pages: 1121-1127
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16601002
[Journal Article] Regulation of Cardiomyocyte functions by distinct phosphoinositide 3-kinase2005
- Author(s)
  Aki, T.
- Journal Title
  
  Molecular Mechanisms of Heart diseases 1
  
  Pages: 85-99
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16601002
[Journal Article] ERK1/2regulates intracellular ATP levels through a-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation2004
- Author(s)
  Mizukami, Y., Iwamatsu, A., Aki, T., Kimura, M, Nakamura, K., Nao, T., Ohkusa, T., Matsuzaki, T., Yoshida, K., Kobayashi, S.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 50120-50131
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16601002
[Journal Article] Mechanism of the generation of autonomous activity of Ca2+/calmodulin-dependent protein kinase IV2004
- Author(s)
  Tokumitsu H, Hatano N, Inuzuka H, Yokokura S, Nozaki N, Kobayashi R.
- Journal Title
  
  J.Biol.Chem. 279(39)
  
  Pages: 40296-40302
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16601002
[Presentation] コカイン投与によるラット胸腺の組織学的検討2023
- Author(s)
  鵜沼香奈、秋利彦、温書恒、船越丈司、上村公一
- Organizer
  第107次日本法医学会学術全国集会
- Data Source
  KAKENHI-PROJECT-23K09760
[Presentation] Contraction Band and Dephosphorylated Cardiac Connexin 43 after Daily Cocaine Administration2023
- Author(s)
  温書恒、鵜沼香奈、船越丈司、秋利彦、上村公一
- Organizer
  第107次日本法医学会学術全国集会
- Data Source
  KAKENHI-PROJECT-23K09760
[Presentation] 三酸化二ヒ素による酸化ストレス及び抗酸化防御機構の検討2023
- Author(s)
  長野修太郎、鵜沼香奈、秋利彦、上村公一
- Organizer
  第107次日本法医学会学術全国集会
- Data Source
  KAKENHI-PROJECT-23K09760
[Presentation] 持続型硫化水素発生剤に対する細胞応答のA549ヒト肺胞上皮細胞モデルを用いた検討2021
- Author(s)
  梶原美祐、秋利彦、加藤千鶴、船越丈司、青木奨、鵜沼香奈、上村公一
- Organizer
  第90回日本法医学会学術関東地方集会
- Data Source
  KAKENHI-PROJECT-19K10682
[Presentation] アリストロキア酸による近位尿細管細胞への細胞毒性の検討2021
- Author(s)
  小松美結 , 船越丈司 , 秋利彦 , 上村公一
- Organizer
  第105次日本法医学会全国集会
- Data Source
  KAKENHI-PROJECT-19K10682
[Presentation] ヒ素の神経細胞特異的な毒性機序の解明2020
- Author(s)
  溝部万純、秋利彦、船越丈司、平山菜穂、渡邊嶺、永井みどり、野村萌夏、上村公一
- Organizer
  第89回日本法医学会学術関東地方集会
- Data Source
  KAKENHI-PROJECT-19K10682
[Presentation] コカイン反復投与ラットにおける主要臓器変性の検索2020
- Author(s)
  野村萌夏，鵜沼香奈，永井みどり，秋利彦，上村公一
- Organizer
  第104次日本法医学会学術全国集会、京都府、京都市
- Data Source
  KAKENHI-PROJECT-18K19670
[Presentation] LPS 刺激マクロファージ様細胞におけるパイロトーシスと一酸化炭素発生剤の抑制作用2020
- Author(s)
  秋利彦，船越丈司，佐野智美，則竹香菜子，上村公一
- Organizer
  第104次日本法医学会学術全国集会、京都府、京都市
- Data Source
  KAKENHI-PROJECT-20H03955
[Presentation] ヒ素の神経細胞特異的な毒性機序の解明2020
- Author(s)
  溝部万純、秋利彦、船越丈司、平山菜穂、渡邊嶺、永井みどり、野村萌夏、上村公一
- Organizer
  日本法医学会第89回学術関東地方集会
- Data Source
  KAKENHI-PROJECT-19K10681
[Presentation] LPS 刺激マクロファージ様細胞におけるパイロトーシスと一酸化炭素発生剤の抑制作用2020
- Author(s)
  秋利彦，船越丈司，佐野智美，則竹香菜子，上村公一
- Organizer
  第104次日本法医学会学術全国集会、京都府、京都市
- Data Source
  KAKENHI-PROJECT-18K19670
[Presentation] コカイン反復投与ラットにおける主要臓器変性の検索2020
- Author(s)
  野村萌夏，鵜沼香奈，永井みどり，秋利彦，上村公一
- Organizer
  第104次日本法医学会学術全国集会、京都府、京都市
- Data Source
  KAKENHI-PROJECT-20H03955
[Presentation] 敗血症性肝障害に対する硫化水素の影響2019
- Author(s)
  鵜沼香奈、秋利彦、吉川綾香、上村公一
- Organizer
  第103 次日本法医学会学術全国集会、仙台
- Data Source
  KAKENHI-PROJECT-17H04147
[Presentation] コカイン長期曝露による神経細胞ミトコンドリアダイナミクスへの影響2019
- Author(s)
  船越丈司、古川真子、秋利彦、上村公一
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K10682
[Presentation] エタノール以外のアルコールによる細胞毒性研究2019
- Author(s)
  則竹香菜子, 秋利彦, 上村公一
- Organizer
  2019年度アルコール・薬物依存関連学会合同学術総会、札幌
- Data Source
  KAKENHI-PROJECT-18K19670
[Presentation] コカイン長期曝露による神経細胞ミトコンドリアダイナミクスへの影響2019
- Author(s)
  船越丈司、古川真子、秋利彦、上村公一
- Organizer
  第42 回日本分子生物学会年会、福岡
- Data Source
  KAKENHI-PROJECT-18K19670
[Presentation] 神経細胞におけるコカイン長期曝露の影響について2018
- Author(s)
  古川真子, 秋利彦, 船越丈司, 鵜沼香奈, 平山菜穂, 渡邊嶺, 上村公一.
- Organizer
  第87 回日本法医学会学術関東地方集会
- Data Source
  KAKENHI-PROJECT-16K09202
[Presentation] Paraquat-induced cell death pathway, mitochondrial stress and autophagy in human neuronal cell line SH-SY5Y.2018
- Author(s)
  Naho Hirayama, Toshihiko Aki, Koichi Uemura
- Organizer
  IALM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19670
[Presentation] SH-SY5Y human neuroblastoma cell death by methamphetamine involves downregulation of cell cycle regulators.2018
- Author(s)
  Rina Kaseda, Toshihiko Aki, Koichi Uemura
- Organizer
  IALM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19670
[Presentation] クロルプロマジン曝露におけるラットグリア細胞由来C6 細胞の細胞死について2018
- Author(s)
  高橋蓮穂, 秋利彦, 船越丈司, 鵜沼香奈, 則竹香菜子, 永井みどり, 佐野智美, 上村公一
- Organizer
  第87 回日本法医学会学術関東地方集会
- Data Source
  KAKENHI-PROJECT-16K09202
[Presentation] Down-regulation of cardiac contractile protein is involved in cardiac dysfunction during sepsis and is mitigated by carbon monoxide.2018
- Author(s)
  Kana Unuma, Toshihiko Aki, Ryo Watanabe, Koichi Uemura
- Organizer
  IALM 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04147
[Presentation] ラット脳組織における三酸化二ヒ素のPML及びDNA損傷チェックポイント機構への影響2018
- Author(s)
  渡邊嶺、鵜沼香奈、秋利彦、上村公一
- Organizer
  日本生化学会第91回大会
- Data Source
  KAKENHI-PROJECT-16K09201
[Presentation] 覚せい剤原料ノルエフェドリン曝露による神経細胞内コレステロール異常蓄積とネクロトーシス誘導の解析2017
- Author(s)
  船越丈司、秋利彦、鵜沼香奈、則竹香菜子、上村公一
- Organizer
  第101回法医学会全国集会
- Data Source
  KAKENHI-PROJECT-16K09202
[Presentation] ノルエフェドリンによる神経細胞内コレステロール蓄積とネクロトーシス誘導の解析2017
- Author(s)
  船越丈司,秋利彦,鵜沼香奈,則竹香菜子,上村公一
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K09202
[Presentation] エタノールによる心筋細胞死は YAP 活性化により抑制される2017
- Author(s)
  則竹香菜子, 秋　利彦, 上村公一
- Organizer
  第52回日本アルコール・アディクション医学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04147
[Presentation] 神経細胞SH-SY5Yにおけるパラコート曝露による細胞死とそのメカニズムの検討2017
- Author(s)
  平山菜穂、秋利彦、上村公一
- Organizer
  第86回日本法医学会学術関東地方集会
- Data Source
  KAKENHI-PROJECT-17H04147
[Presentation] 三酸化二ヒ素の中枢神経系におけるPML 及びDNA 損傷チェックポイント機構への影響.2016
- Author(s)
  渡邊嶺, 鵜沼香奈, 秋利彦, 上村公一
- Organizer
  第85 回日本法医学会学術関東地方集会
- Place of Presentation
  横須賀
- Data Source
  KAKENHI-PROJECT-16K09201
[Presentation] パラコートによる呼吸器上皮細胞の上皮間葉転換誘導後の線維化とその細胞保護的役割の検討2015
- Author(s)
  山田真嗣，秋利彦，上村公一
- Organizer
  第88回日本生化学会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460862
[Presentation] 平滑筋細胞へのコカイン曝露によるMFG-E8の増加とその病態生理学的意義2015
- Author(s)
  木村（小島）遥、鵜沼香奈、秋利彦、上村公一
- Organizer
  第88回日本生化学会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25460862
[Presentation] HL-1心筋細胞においてエタノールは細胞間接着・細胞骨格を破綻し、Hippo経路の機能を障害する2015
- Author(s)
  則竹香菜子、秋利彦、上村公一
- Organizer
  第88回日本生化学会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25460862
[Presentation] アルコールの毒性と心筋細胞障害2015
- Author(s)
  則竹香菜子、秋　利彦、上村公一
- Organizer
  第50回日本アルコール・薬物医学会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-10-03
- Invited
- Data Source
  KAKENHI-PROJECT-25460862
[Presentation] Activation of ubiquitin-proteasome system plays a protective role in arsenic trioxide-induced cardiotoxicity2014
- Author(s)
  Mayumi Watanabe, Takeshi Funakoshi, Kana Unuma, Toshihiko Aki, Koichi Uemura
- Organizer
  9th International Symposium on Advances in Legal Medicine
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25460863
[Presentation] 抗精神病薬ハロペリドールによるコレステロール代謝変2014
- Author(s)
  相原瑶、船越丈司、加藤千鶴、秋利彦、上村公一
- Organizer
  第83回日本法医学会学術関東地方集会
- Place of Presentation
  東京都新宿区東京女子医科大学
- Year and Date
  2014-11-08
- Data Source
  KAKENHI-PROJECT-25460862
[Presentation] アルコールによる心筋細胞への影響2014
- Author(s)
  則竹香菜子、秋　利彦、上村公一
- Organizer
  第49回日本アルコール・薬物医学会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Year and Date
  2014-10-03
- Invited
- Data Source
  KAKENHI-PROJECT-25460862
[Presentation] 覚せい剤原料ノルエフェドリン暴露による細胞内コレステロール変動の解析2013
- Author(s)
  船越丈司，秋利彦，鵜沼香奈，上村公一
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  兵庫県神戸市神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25460862
[Presentation] コカインによるアポトーシス誘導におけるオートファジー・リソソームの関与2013
- Author(s)
  小島遥、則竹香菜子、藤井祐介、船越丈司、秋利彦、上村公一
- Organizer
  第82回日本法医学会学術関東地方集会
- Place of Presentation
  神奈川県横浜市はまぎんホール
- Data Source
  KAKENHI-PROJECT-25460862
[Presentation] 敗血症モデルラットの角膜におけるオートファジー誘導性転写因子TFEBの活性化2013
- Author(s)
  内田恭子、鵜沼香奈、船越丈司、秋利彦、上村公一
- Organizer
  第82回日本法医学会学術関東地方集会
- Place of Presentation
  神奈川県横浜市はまぎんホール
- Data Source
  KAKENHI-PROJECT-25460862
[Presentation] 心筋ギャップ結合制御機構に及ぼすエタノールの影響2013
- Author(s)
  則竹香菜子、秋利彦、上村公一
- Organizer
  平成 25年度アルコール・薬物依存関連学会合同学術総会
- Place of Presentation
  岡山県岡山市岡山コンベンションセンター
- Data Source
  KAKENHI-PROJECT-25460862
[Presentation] エタノールが心筋ギャップ結合に及ぼす影響2013
- Author(s)
  則竹香菜子、秋利彦、上村公一
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25460862
[Presentation] マウス心房由来心筋細胞HL-1におけるメタンフェタミンの毒性2012
- Author(s)
  船越泉、鵜沼香奈、則竹香菜子、秋利彦、上村公一
- Organizer
  第85回日本生化学会
- Place of Presentation
  福岡
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] 敗血症モデル動物の前房水、硝子体、水晶体における構成タンパク質の変動の検討2012
- Author(s)
  内田恭子、鵜沼香奈、船越丈司,秋利彦、上村公一
- Organizer
  第96回日本法医学会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] 覚せい剤原料ノルエフェドリンによる神経細胞毒性機序の検討2012
- Author(s)
  船越丈司,秋利彦,鵜沼香奈,上村公一
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] 亜ヒ酸によるRhoキナーゼ依存的なアポトーシスの誘導2012
- Author(s)
  別所麻里江、則竹香菜子、藤井祐介、秋利彦、上村公一
- Organizer
  第81回日本法医学会学術関東地方集会
- Place of Presentation
  高崎
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] ラット肺上皮由来L2細胞における硫化水素の毒性の検討2012
- Author(s)
  藤井祐介、船越丈司、秋利彦、上村公一
- Organizer
  第85回日本生化学会
- Place of Presentation
  福岡
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] 筋芽細胞におけるコカインの細胞毒性2011
- Author(s)
  綿貫裕美、秋利彦、則竹香菜子、船越丈司、上村公一
- Organizer
  第80回日本法医学会学術関東地方集会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] Methamphetamine-caused cytotoxic effects involvesmacropinocytosis in differentiatedSH-SY5Y cells2011
- Author(s)
  奈良明奈,秋利彦,船越丈司,鵜沼香奈,上村公一
- Organizer
  第95回日本法医学会
- Place of Presentation
  福島
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] Signaling pathway of macropinocytosis bymethamphetamine in human neuroblastoma cells2011
- Author(s)
  Akina Nara, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma and Koichi Uemura
- Organizer
  6th International Symposium Advances in Legal Medicine
- Place of Presentation
  ドイツ
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] Involvement of Rho-associated kinase in the cytotoxity of 1-butanol2011
- Author(s)
  則竹香菜子,秋利彦,加藤千鶴,白鳥典,上村公一
- Organizer
  第95回日本法医学会
- Place of Presentation
  福島
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] Methamphetamine-caused cytotoxic effects involves macropinocytosis in differentiated SH-SY5Y cells2011
- Author(s)
  奈良明奈, 秋利彦, 船越丈司, 鵜沼香奈, 上村公一
- Organizer
  第95回日本法医学会
- Place of Presentation
  福島
- Year and Date
  2011-06-15
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] ヒト神経芽細胞腫由来SH-SY5Yにおける虚血再灌流時のチロシン水酸化酵素の発現誘導2011
- Author(s)
  秋利彦、船越丈司、鵜沼香奈、上村公一
- Organizer
  第95回日本法医学会
- Place of Presentation
  福島
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] 硫化水素による心筋障害の検討2010
- Author(s)
  白鳥典、船越丈司、鵜沼香奈、秋利彦、上村公一
- Organizer
  第79回日本法医学会学術関東地方集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] Neurotoxic effects of norephedrine in SH-SY5Y humanneuroblastoma cells2010
- Author(s)
  船越丈司、内田恭子、奈良明奈、白鳥典、則竹香菜子、鵜沼香奈、秋利彦、上村公一
- Organizer
  第33回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] 低酸素による細胞死に対するグルコースの効果は、濃度により抑制的から促進的に変動する2010
- Author(s)
  秋利彦、奈良明奈、船越丈司、上村公一
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] 低酸素による細胞死に対するグルコースの効果は濃度により抑制的から促進的に変動する2010
- Author(s)
  秋利彦
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸国際展示場
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] 覚せい剤原料ノルエフェドリンによる神経細胞毒性機序の検討2010
- Author(s)
  船越丈司,秋利彦,鵜沼香奈,上村公一
- Organizer
  第94回日本法医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590629
[Presentation] マウス心房細胞由来HL-1細胞の亜砒酸誘導性アポトーシスにおけるユビキチン－プロテアソーム系の抑制作用
- Author(s)
  渡邉　まゆ美、船越　丈司、鵜沼　香奈、秋　利彦、上村　公一
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25460863

1. FUNAKOSHI Takeshi (40444715)

# of Collaborated Projects: 11 results

# of Collaborated Products: 53 results
2. UEMURA Koichi (30244586)

# of Collaborated Projects: 7 results

# of Collaborated Products: 58 results
3. YOSHIDA Ken-ichi (40166947)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MIZUKAMI Yoichi (80274158)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. 則竹香菜子 (40758067)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
6. HATANO Naoya (10332280)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 原田一樹 (00253146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 鵜沼香奈 (30586425)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
9. WATANABE Ryo

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. やなぎ澤修一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Aki Toshihiko 秋 利彦

AKI Toshihiko 秋 利彦

Research Projects

Research Products

Co-Researchers

ヒ素肝毒性の分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation mechanism of pyroptosis by metabolitesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cell death by chemicals and possible involvement of regulated necrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of carbon monoxide toxicity using water-soluble CORMsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular analysis of drug intoxication by use of integrated toxicomicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proteomic screening of possible marker proteins for drug-induced cellular injuriesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

心筋虚血細胞死におけるオートファジー様細胞死の関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

虚血心筋におけるGAPDH遺伝子発現の分子機構と細胞死(アポトーシス)誘導機序Principal Investigator

Principal Investigator

Project Period (FY)

Aki Toshihiko 秋利彦

AKI Toshihiko 秋利彦