Takahashi Yoshimasa 高橋宜聖

… Alternative Names

TAKAHASHI Yoshimasa 高橋宜聖

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Researcher Number	60311403
Other IDs
External Links
Affiliation (Current)	2025: 国立感染症研究所, 治療薬・ワクチン開発研究センター, センター長
Affiliation (based on the past Project Information) *help	2021 – 2024: 国立感染症研究所, 治療薬・ワクチン開発研究センター, センター長 2020: 国立感染症研究所, 免疫部, 部長 2017 – 2018: 国立感染症研究所, 免疫部, 部長 2010 – 2016: National Institute of Infectious Diseases, 免疫部, 室長 2010: 東京大学, 国立感染症研究所・免疫部, 室長 … More 2002 – 2009: 国立感染症研究所, 免疫部, 主任研究官 2006: National Institute of Infectious Diseases, Dept. Immunology, Researcher, 免疫部, 主任研究員 1999 – 2003: 国立感染症研究所, 免疫部, 研究員 2001: 国立感染症研究所, 免疫部, 部長 Less
Review Section/Research Field	Principal Investigator Immunology / Basic Section 49070:Immunology-related / Immunology Except Principal Investigator Biological Sciences / Immunology / Food science / Basic Section 54030:Infectious disease medicine-related / Immunology
Keywords	Principal Investigator インフルエンザ / B細胞 / 免疫記憶 / 胚中心 / 記憶B細胞 / 交差反応性抗体 / 免疫学 / 抗体 / 腸内細菌 / 抗体産生 … More / survival motor neuron / アポトーシス / クローン選択 / Fas / サブトラクティブハイブリダイゼーション … More Except Principal Investigator 記憶B細胞 / Ras / 抗原受容体 / 体細胞変異 / 胚中心 / survival / 進化 / 遺伝子再編成 / VLR / 無顎類 / 獲得免疫系 / 制御性T細胞 / IgA抗体 / 樹状細胞 / アポトーシス / AIF / SMN / NKT細胞 / 糖脂質 / 抗体 / ワクチン / AID / affinity selection / apoptosis / somatic mutations / Germinal center / memory B cells / 生存維持 / secondary response / 胚中心B細胞 / 免疫記憶 / IgA / 食品 / TLR / 経口免疫寛容 / 機能性食品 / サイトカイン / ケモカイン / 遺伝子スクリーニング / 長期生存因子 / 新規ワクチン開発 / Fas / 高親和性 / 抗体産生細胞 / lprマウス / 肺炎 / 肺炎球菌 / NKT / 肺炎球菌感染症 / ゲノム再編成 / copy choice / トランスポゾン / 獲得免疫 / Somatic mutations / committment / memory B cell genes / memory B cell / 抗アポトーシス / 呼吸鎖複合体 / ミトコンドリア / 抗アポトーシス活性 / 抗酸化ストレス / 記憶B細胞系列決定 / 系列決定 / 二次免疫反応 / 長期生存 / 特異的遺伝子 / 長期生存抗体産生細胞 / 変異マウス / SMN exon7 / PRMT6 / inportinβ3 / 細胞死抵抗性 / スフィンゴシン-1-リン酸 / Alternative Splicing / 細胞死 / 3940 / デコイ受容体 / ケモカイン受容体 / 辺縁帯B細胞 / トランスジェニックマウス / クローニング / Bcl-6 / Fasリガンド / high-affinity / class-switch / germinal center / Nasal-associated lymphoid tissue / immunological memory / mucosal immunity / IgA antibodies / IgG抗体 / 高親和性抗体 / 抗原親和性 / クラス変換 / 粘膜免疫 / NALT / 腸内細菌叢 / 濾胞性ヘルパーT細胞 / 濾胞性T細胞 / 乳酸菌 / 腸管免疫 / 食品免疫 / 食品機能 / 感染防御 / 制御性Ｔ細胞 / 腸内共生菌 / 腸管免疫系 / T細胞 / ルモリー亜集団 / NP-CGG / 液性免疫 / メモリー亜集団 / 細胞増殖 / メモリーTfh / 存在部位 / 液性免疫記憶 / 感染症 / パイエル板 / 食品免疫学 / アレルギー / 腸管 / 免疫機能食品 / UV照射不活化ワクチン / 免疫応答 / 不活化ワクチン / SARSコロナウイルス / RNA代謝 / FAD結合領域 / snRNP / SMA / forbiddenクローン / 白血病化 / Hox11 / FAS / シグナル / Ha-ras / 細胞移入 / RAG1 / Ig遺伝子 / CD95(Fas) Less

高親和性抗体の産生及び持続をもたらす免疫応答の解明とワクチンへの応用
- Principal Investigator
  
  金城雄樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Jikei University School of Medicine
インフルエンザ交差反応性抗体の選択と防御メカニズムの解明Principal Investigator
- Principal Investigator
  
  高橋宜聖
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  National Institute of Infectious Diseases
The mechanism of NKT cell-mediated persistent antibody production and host protection by a new pneumococcal vaccine
- Principal Investigator
  
  Kinjo Yuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Jikei University School of Medicine
The origin of apattive immunity
- Principal Investigator
  
  Nagawa Fumikiyo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Regulation of influenza protective antibody responses by microbiotaPrincipal Investigator
- Principal Investigator
  
  Takahashi Yoshimasa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  National Institute of Infectious Diseases
Immunomodulation by foods based on elucidation of novel interactions of intestinal immune cells
- Principal Investigator
  
  HACHIMURA Satoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  The University of Tokyo
Adaptive immune system and intestinal flora in jawless vertebrates
- Principal Investigator
  
  Nagawa Fumikiyo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Origin and evolution of non-self discrimination in adaptive immunirty
- Principal Investigator
  
  NAGAWA Fumikiyo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Elucidation of recognition and response of intestinal immune cells to microbes in relation to development of immunomodulating functional foods
- Principal Investigator
  
  HACHIMURA SATOSHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  The University of Tokyo
Mechanisms of Generation, Maintenance, and Activation of Humoral Memory
- Principal Investigator
  
  KUROSAKI Tomohiro
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Elucidation of immunoregulatory function of intestinal immunoregulatory cells and its application to anti-infectious and anti-allergic food
- Principal Investigator
  
  HACHIMURA Satoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  The University of Tokyo
Functional analysis of memory B cells in lungsPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Yoshimasa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  National Institute of Infectious Diseases
メモリーB細胞の最終分化を促進する分子メカニズムの解析Principal Investigator
- Principal Investigator
  
  高橋宜聖
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  National Institute of Infectious Diseases
SARS-coronavirusワクチン開発に関する基礎研究
- Principal Investigator
  
  横田恭子
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Infectious Diseases
Memory B cell commitment, maintenance and terminal differentiation
- Principal Investigator
  
  TAKEMORI Toshitada
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  RIKEN
  National Institute of Infectious Diseases
持続性に優れたワクチン開発のための記憶B細胞長期生存に関わる因子の同定
- Principal Investigator
  
  竹森利忠
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Infectious Diseases
RNA結合タンパク質(snRNP)複合体を形成するSMNの生物学的機能の解明
- Principal Investigator
  
  竹森利忠
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Infectious Diseases
アポトーシス制御分子による免疫記憶の維持調節機構Principal Investigator
- Principal Investigator
  
  高橋宜聖
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  National Institute of Infectious Diseases
Molecular mechanism for memory B cell dynamics and survival
- Principal Investigator
  
  TAKEMORI Toshitada
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  NATIONAL INSTITUTE OF INFECTIOUS DISEASES
持続性に優れたワクチン開発のための記憶B細胞長期生存に関わる因子の同定
- Principal Investigator
  
  竹森利忠
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Infectious Diseases
記憶B細胞選択に関わるポジティブ、ネガティブセレクションの分子機構の解明
- Principal Investigator
  
  竹森利忠
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Infectious Diseases
Molecular events in the generation of memory B cells.
- Principal Investigator
  
  TAKEMORI Toshitada
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  NATIONAL INSTITUTE OF INFECTIOUS DISEASES
記憶B細胞選択、維持を司るシゲナルと分子設計の解明
- Principal Investigator
  
  TOSHITADA Takemori
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Infectious Diseases
記憶Bリンパ球の産生・維持機構の解析Principal Investigator
- Principal Investigator
  
  高橋宜聖
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  National Institute of Infectious Diseases
粘膜免疫系における記憶B細胞の選択機構
- Principal Investigator
  
  TOSHITADA Takemori
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  NATIONAL INSTITUTE OF INFECTIOUS DISEASES

[Book] 次世代アジュバント開発のためのメカニズム解明と安全性評価2017
- Author(s)
  高橋宜聖
- Total Pages
  6
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-16K15296
[Journal Article] Post-fusion influenza vaccine adjuvanted with SA-2 confers heterologous protection via Th1-polarized, non-neutralizing antibody responses2023
- Author(s)
  Nishiyama Ayae、Adachi Yu、Tonouchi Keisuke、Moriyama Saya、Sun Lin、Aoki Masamitsu、Asanuma Hideki、Shirakura Masayuki、Fukushima Akihisa、Yamamoto Takuya、Takahashi Yoshimasa
- Journal Title
  
  Vaccine
  
  Volume: 41 Issue: 31 Pages: 4525-4533
- DOI
  10.1016/j.vaccine.2023.06.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-22KJ2889
[Journal Article] Systemically inoculated adjuvants stimulate pDC-dependent IgA response in local site2023
- Author(s)
  Sasaki Eita、Asanuma Hideki、Momose Haruka、Furuhata Keiko、Mizukami Takuo、Matsumura Takayuki、Takahashi Yoshimasa、Hamaguchi Isao
- Journal Title
  
  Mucosal Immunology
  
  Volume: - Issue: 3 Pages: 275-286
- DOI
  10.1016/j.mucimm.2023.03.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-22K12901, KAKENHI-PROJECT-20K16269
[Journal Article] Structural basis for cross-group recognition of an influenza virus hemagglutinin antibody that targets postfusion stabilized epitope2023
- Author(s)
  Tonouchi K, Adachi Y, Suzuki T, Kuroda D, Nishiyama A, Yumoto K, Takeyama H, Suzuki T, Hashiguchi T, Takahashi Y.
- Journal Title
  
  PLoS Pathog .
  
  Volume: 19(8) Issue: 8 Pages: e1011554-e1011554
- DOI
  10.1371/journal.ppat.1011554
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-21K08192, KAKENHI-PROJECT-22KJ2889, KAKENHI-PROJECT-23K27422
[Journal Article] An influenza HA stalk reactive polymeric IgA antibody exhibits anti-viral function regulated by binary interaction between HA and the antibody2021
- Author(s)
  Sano Kaori、Saito Shinji、Suzuki Tadaki、Kotani Osamu、Ainai Akira、van Riet Elly、Tabata Koshiro、Saito Kumpei、Takahashi Yoshimasa、Yokoyama Masaru、Sato Hironori、Maruno Takahiro、Usami Kaede、Uchiyama Susumu、Ogawa-Goto Kiyoko、Hasegawa Hideki
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 1 Pages: 0245244-0245244
- DOI
  10.1371/journal.pone.0245244
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-19K17945, KAKENHI-PROJECT-20H03500, KAKENHI-PROJECT-20J22269, KAKENHI-PROJECT-19K17947
[Journal Article] Tissue-resident CD4+ T helper cells assist the development of protective respiratory B and CD8+ T cell memory responses2021
- Author(s)
  Son Young Min、Cheon In Su、Wu Yue、Li Chaofan、Wang Zheng、Gao Xiaochen、Chen Yao、Takahashi Yoshimasa、Fu Yang-Xin、Dent Alexander L.、Kaplan Mark H.、Taylor Justin J.、Cui Weiguo、Sun Jie
- Journal Title
  
  Science Immunology
  
  Volume: 6 Issue: 55 Pages: 6852-6852
- DOI
  10.1126/sciimmunol.abb6852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07545
[Journal Article] SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells2021
- Author(s)
  Kanno Toshio、Nakajima Takahiro、Yokoyama Satoru、Asou Hikari K.、Sasamoto Shigemi、Kamii Yasuhiro、Hayashizaki Koji、Ouchi Yasuo、Onodera Taishi、Takahashi Yoshimasa、Ikeda Kazutaka、Hasegawa Yoshinori、Kinjo Yuki、Ohara Osamu、Nakayama Toshinori、Endo Yusuke
- Journal Title
  
  Communications Biology
  
  Volume: 4(1) Issue: 1 Pages: 820-820
- DOI
  10.1038/s42003-021-02310-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-20K21618, KAKENHI-PROJECT-19K16704, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-21K07085, KAKENHI-PROJECT-21K15476, KAKENHI-PROJECT-19H03705, KAKENHI-PROJECT-17KK0189, KAKENHI-PROJECT-20K07651
[Journal Article] Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells2021
- Author(s)
  Miyauchi Kosuke、Adachi Yu、Tonouchi Keisuke、Yajima Taiki、Harada Yasuyo、Fukuyama Hidehiro、Deno Senka、Iwakura Yoichiro、Yoshimura Akihiko、Hasegawa Hideki、Yugi Katsuyuki、Fujii Shin-ichiro、Ohara Osamu、Takahashi Yoshimasa、Kubo Masato
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41467-021-24090-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-21K08192
[Journal Article] Stereotyped B-cell response that counteracts antigenic variation of influenza viruses2020
- Author(s)
  Tonouchi Keisuke、Adachi Yu、Moriyama Saya、Sano Kaori、Tabata Koshiro、Ide Keigo、Takeyama Haruko、Suzuki Tadaki、Takahashi Yoshimasa
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 9 Pages: 613-621
- DOI
  10.1093/intimm/dxaa038
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-20H03500, KAKENHI-PROJECT-20J22269, KAKENHI-PROJECT-19K17656
[Journal Article] Memory B Cells in Local and Systemic Sites2020
- Author(s)
  Moriyama Saya、Adachi Yu、Tonouchi Keisuke、Takahashi Yoshimasa
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 1254 Pages: 55-62
- DOI
  10.1007/978-981-15-3532-1_5
- ISBN
  9789811535314, 9789811535321
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-19K17656
[Journal Article] Hide and seek: interplay between influenza viruses and B cells2020
- Author(s)
  Kuraoka Masayuki、Adachi Yu、Takahashi Yoshimasa
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 9 Pages: 605-611
- DOI
  10.1093/intimm/dxaa028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-19K17656
[Journal Article] Role of germinal centers for the induction of broadly-reactive memory B cells.2017
- Author(s)
  Takahashi Y, Kelsoe G
- Journal Title
  
  Current Opinion in Immunology
  
  Volume: 45 Pages: 119-125
- DOI
  10.1016/j.coi.2017.03.002
- Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15296
[Journal Article] Protective neutralizing influenza antibody response in the absence of T follicular helper cells2016
- Author(s)
  Miyauchi K, Sugimoto-Ishige A, Harada Y, Adachi Y, Usami Y, Kaji T, Inoue K, Hasegawa H, Watanabe T, Hijikata A, Fukuyama S, Maemura T, Okada-Hatakeyama M, Ohara O, Kawaoka Y, Takahashi Y, Takemori T, Kubo M
- Journal Title
  
  Nature Immunology
  
  Volume: 17(12) Issue: 12 Pages: 1447-1458
- DOI
  10.1038/ni.3563
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01162, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-16K15296
[Journal Article] Continuous intake of resistant maltodextrin enhanced intestinal immune response through changes in the intestinal environment in mice2016
- Author(s)
  Miyazato S, Kishimoto Y, Takahashi K, Kaminogawa S, Hosono A
- Journal Title
  
  Bioscience of Microbiota, Food and Health
  
  Volume: 35 Issue: 1 Pages: 1-7
- DOI
  10.12938/bmfh.2015-009
- NAID
  130005123740
- ISSN
  2186-3342
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07443, KAKENHI-PROJECT-26450165, KAKENHI-PROJECT-26292065
[Journal Article] Post-transcriptional regulation of Toll-interacting protein in the intestinal epithelium2016
- Author(s)
  Y. Sugi, K. Takahashi, K. Kurihara, K. Nakata, H. Narabayashi, Y. Hamamoto, M. Suzuki, M. Tsuda, S. Hanazawa, A. Hosono, S. Kaminogawa
- Journal Title
  
  PLoS ONE
  
  Volume: 11 Issue: 10 Pages: e0164858-e0164858
- DOI
  10.1371/journal.pone.0164858
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26292065, KAKENHI-PROJECT-26450165, KAKENHI-PROJECT-15K07443
[Journal Article] Regulated selection of germinal center cells into the memory B cell compartment.2016
- Author(s)
  Shinnakasu, R., Inoue, T., Kometani, K., Moriyama, S., Adachi, Y., Nakayama, M., Takahashi, Y., Fukuyama, H., Okada, T.,Kurosaki,T.
- Journal Title
  
  Nat. Immunol.
  
  Volume: 17 Issue: 7 Pages: 861-9
- DOI
  10.1038/ni.3460
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26221306, KAKENHI-PROJECT-15K19127, KAKENHI-PROJECT-16K15289, KAKENHI-PROJECT-16K15296
[Journal Article] Generation of memory B cells inside and outside germinal centers2014
- Author(s)
  Takemori, T., Kaji, T., Takahashi, Y., Shimoda, M., Rajewsky, K
- Journal Title
  
  Eur. J. Immunol
  
  Volume: 44 Issue: 5 Pages: 1258-1264
- DOI
  10.1002/eji.201343716
- Data Source
  KAKENHI-PROJECT-23380073, KAKENHI-PROJECT-26292065
[Journal Article] Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice.2014
- Author(s)
  Kikuchi, Y., Kunitoh-Asari, A., Hayakawa, K., Imai, S., Kasuya, K., Abe, K., Adachi, Y., Fukudome, S., Takahashi, Y., Hachimura, S.
- Journal Title
  
  PLoSONE
  
  Volume: 9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380073
[Journal Article] Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice2014
- Author(s)
  Kikuchi, Y., Kunitoh-Asari, A., Hayakawa, K., Imai, S., Kasuya, K., Abe, K., Adachi, Y., Fukudome, S., Takahashi, Y., Hachimura, S
- Journal Title
  
  PLoS ONE
  
  Volume: 9, e86416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380073
[Journal Article] Epitope Mapping of the Hemagglutinin Molecule of A/(H1N1)pdm09 Virus by Using Monoclonal Antibody Escape Mutants2014
- Author(s)
  Yoko Matsuzaki, Kanetsu Sugawara., Mina Nakauchi, Yoshimasa Takahashi, Taishi Onodera, Yasuko Tsunetsugu-Yokota, Takayuki Matsumura, Manabu Ato, Kazuo Kobayashi, Yoshitaka Shimotai, Katsumi Mizuta, Seiji Hongo, Masato Tashiro, Eri Nobusawa
- Journal Title
  
  J. Virol.
  
  Volume: 88 Issue: 21 Pages: 12364-12373
- DOI
  10.1128/jvi.01381-14
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26292065, KAKENHI-PROJECT-26460547
[Journal Article] Commensal bacteria directly suppress in vitro degranulation of mast cells in a MyD88-independent manne2014
- Author(s)
  Kazumi Kasakura, Kyoko Takahashi, Tomoko Itoh, Akira Hosono, Yoshika Momose, Kikuji Itoh, Chiharu Nishiyama, Shuichi Kaminogawa
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 78 Issue: 10 Pages: 1669-1676
- DOI
  10.1080/09168451.2014.930327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26292065, KAKENHI-PROJECT-26450165
[Journal Article] IgA production in the large intestine is modulated by a different mechanism than in the small intestine: Bacteroides acidifaciens promotes IgA production in the large intestine by inducing germinal center formation and increasing the number of IgA+ B cells.2013
- Author(s)
  Tsutomu Yanagibashia, Akira Hosono, Akihito Oyama, Masato Tsuda, Ami Suzuki, Satoshi Hachimura, Yoshimasa Takahashi, Yoshika Momose, Kikuji Itoh, Kazuhiro Hirayama, Kyoko Takahashi, Shuichi Kaminogawa
- Journal Title
  
  Immunobiology
  
  Volume: 218 Issue: 4 Pages: 645-651
- DOI
  10.1016/j.imbio.2012.07.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23228003, KAKENHI-PROJECT-23380073, KAKENHI-PROJECT-23580186, KAKENHI-PROJECT-24580200
[Journal Article] Influenza A whole virion vaccine induces a rapid reduction of peripheral blood leukocytes via interferon-α-dependent apoptosis.2013
- Author(s)
  Ato M, Takahashi Y, Fujii H, Hashimoto S, Kaji T, Itamura S, Horiuchi Y, Arakawa Y, Tashiro M, Takemori T.
- Journal Title
  
  Vaccine.
  
  Volume: 31(17) Issue: 17 Pages: 2184-90
- DOI
  10.1016/j.vaccine.2013.02.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590437, KAKENHI-PROJECT-23380073
[Journal Article] Both unmutated and mutated memory B cells accumulate mutations and renew antibody repertoire optimally adopted to antigen upon re-exposure2013
- Author(s)
  Kaji, T., Furukawa, K., Ishige, A., Toyokura, I., Takahashi, Y., Shimoda, M., Takemori, T
- Journal Title
  
  Int. Immunol
  
  Volume: 25 Issue: 12 Pages: 683-695
- DOI
  10.1093/intimm/dxt030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380073
[Journal Article] B-Cell Responses to Pulmonary Virus Infection2012
- Author(s)
  Takahashi, Y., Onodera, T., Kobayashi, K., and Kurosaki, T
- Journal Title
  
  Infec. Disord. Drug. Targets
  
  Volume: 12 Pages: 232-40
- Data Source
  KAKENHI-PROJECT-21229007
[Journal Article] Transcription of the Tollip gene is elevated in intestinal epithelial cells through impaired O-GlcNAcylation-dependent nuclear translocation of the negative regulator Elf-12012
- Author(s)
  Sugi Y, Takahashi K, Nakano K, Hosono A, Kaminogawa S
- Journal Title
  
  Biochem.Biophys.Res.Commun
  
  Volume: 412 Issue: 4 Pages: 704-709
- DOI
  10.1016/j.bbrc.2011.08.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580158, KAKENHI-PROJECT-23380073, KAKENHI-PROJECT-23580186
[Journal Article] Commensal bacteria promote migration of mast cells into the intestine2012
- Author(s)
  Kunii J, Takahashi K, Kasakura K, Tsuda M, Nakano K, Hosono A, Kaminogawa S
- Journal Title
  
  Immunobiol
  
  Volume: 216 Issue: 6 Pages: 692-697
- DOI
  10.1016/j.imbio.2010.10.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580158, KAKENHI-PROJECT-23380073
[Journal Article] Epigenetic control of the host gene by commensal bacteria in large intestinal epithelial cells2012
- Author(s)
  Takahashi K, Sugi Y, Nakano K, Tsuda M, Kurihara K, Hosono A, Kaminogawa S
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Issue: 41 Pages: 35755-35762
- DOI
  10.1074/jbc.m111.271007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580158, KAKENHI-PROJECT-23380073, KAKENHI-PROJECT-23580186
[Journal Article] Primary and Secondary B-Cell Responses to Pulmonary Virus Infection.2012
- Author(s)
  Takahashi, Y. et al
- Journal Title
  
  Infec Disord Drug Targets.
  
  Volume: 12 Issue: 3 Pages: 232-240
- DOI
  10.2174/187152612800564400
- Data Source
  KAKENHI-PROJECT-21229007
[Journal Article] Primary and Secondary B-Cell Responses to Pulmonary Virus Infection2012
- Author(s)
  Takahashi, Y., et al
- Journal Title
  
  Infectious Disorders
  
  Volume: (印刷中)
- Data Source
  KAKENHI-PROJECT-21229007
[Journal Article] ウイルス感染局所における記憶B細胞応答2012
- Author(s)
  高橋宜聖, 小野寺大志, 小林和夫
- Journal Title
  
  実験医学増刊
  
  Volume: 29 Pages: 81-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23380073
[Journal Article] Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection2012
- Author(s)
  Onodera, T., Takahashi, Y., Yokoi, Y., Ato, M., Kodama, Y., Hachimura, S., Kurosaki, T., and Kobayashi, K
- Journal Title
  
  Proc. Natl. Acad. Sci. U. S. A.
  
  Volume: 109 Issue: 7 Pages: 2485-90
- DOI
  10.1073/pnas.1115369109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229007, KAKENHI-PROJECT-23380073, KAKENHI-PROJECT-23790553
[Journal Article] Distinct cellular pathways select germ-line encoded and somatically mutated antibodies into immunological memory.2012
- Author(s)
  Kaji, T. et al
- Journal Title
  
  J. Exp. Med.
  
  Volume: 209 Issue: 11 Pages: 2079-2097
- DOI
  10.1084/jem.20120127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229007, KAKENHI-PROJECT-23380073
[Journal Article] ウイルス感染局所における記憶B 細胞応答2011
- Author(s)
  高橋宜聖, 小野寺大志, 小林和夫
- Journal Title
  
  実験医学増刊
  
  Volume: 29 Pages: 81-86
- Data Source
  KAKENHI-PROJECT-23380073
[Journal Article] ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation2011
- Author(s)
  Yasuda T., Kometani, K., Takahashi, N., Imai, Y., Aiba, Y. and Kurosaki, T
- Journal Title
  
  Sci. Signal
  
  Volume: 4, (169) Issue: 169 Pages: 104-16
- DOI
  10.1126/scisignal.2001592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229007, KAKENHI-PROJECT-21590545, KAKENHI-PROJECT-23689066
[Journal Article] Orally administered Bifidobacterium triggers immune responses following capture by CD11c+cells in Peyer's patches and cecal patches.2011
- Author(s)
  Hiramatsu Y, Hosono A, Konno T, Nakanishi Y, Muto M, Suyama A, Hachimura S, Sato R, Takahashi K, Kaminogawa S.
- Journal Title
  
  Cytotechnology 63
  
  Pages: 307-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380074
[Journal Article] Differential phosphorylation of functional tyrosines in CD19 modulates B lymphocyte activation.2010
- Author(s)
  Ishiura N. Nakashima H., Watanabe R., Kuwano Y., Adachi T., Takahashi Y., Tsubata T., Okochi H., Tamaki K., Tedder T. F., Fujimoto M.
- Journal Title
  
  Eur.J.Immunol. 40
  
  Pages: 1192-1204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590501
[Journal Article] CD22 expression mediates the regulatory functions of peritoneal B-la cells during the remission phase of contact hypersensitivity reactions.2010
- Author(s)
  Nakashima H., Hamaguchi Y., Watanabe R., Ishiura N., Kuwano Y., Okochi H., Takahashi Y., Tamaki K., Sato S., Tedder T. F., Fujimoto M.
- Journal Title
  
  J.Immuno. 184
  
  Pages: 637-4645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590501
[Journal Article] Lack of antibody response to Guillain-Barre syndrome-related gangliosides in mice and men after novel influenza vaccination.2010
- Author(s)
  Yuki N., Takahashi Y., Ihara T., Ito S., Nakajima T., Funakoshi K., Furukawa K., Kobayashi K., Odaka M.
- Journal Title
  
  J.Neurol.Neurosurg.Psychiatry.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590501
[Journal Article] Lack of antibody response to Guillain-Barre syndrome-related gangliosides in mice and men after novel influenza vaccination.2010
- Author(s)
  Yuki, N., Takahashi, Y., Ihara, T., Ito, S., Nakajima, T., Funakoshi, K., Furukawa, K., Kobayashi, K., Odaka, M.
- Journal Title
  
  J.Neurol.Neurosurg.Psychiatry. (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380074
[Journal Article] Intestinal commensal bacteria promote T cell hyporesponsiveness and down-regulate the serum antibody responses induced by dietary antigen.2010
- Author(s)
  Tsuda, M,.Hosono, A, Yanagibashi, T., Kihara-Fujioka, M., Hachimura, S., Itoh, K., Hirayama, K., Takahashi, K., Kaminogawa, S.
- Journal Title
  
  Immunol.Lett. 132
  
  Pages: 45-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380074
[Journal Article] Regulation of antigen-receptor gene assembly in hagfish.2010
- Author(s)
  Kishishita N., Matsuno T., Takahashi Y., Takaba H., Nishizumi H., Nagawa F.
- Journal Title
  
  EMBO.Rep. 11
  
  Pages: 126-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590501
[Journal Article] Unique properties of memory B cells of different isotypes.2010
- Author(s)
  Kurosaki T., Aiba Y., Kometani K., Moriyama S., Takahashi Y.
- Journal Title
  
  Immunol.Rev. 237
  
  Pages: 104-116
- Data Source
  KAKENHI-PROJECT-20590501
[Journal Article] Unique properties of memory B cells of different isotypes.2010
- Author(s)
  Kurosaki, T., Aiba Y., Kometani, K., Moriyama, S., Takahashi, Y.
- Journal Title
  
  Immunol.Rev. 237
  
  Pages: 104-116
- Data Source
  KAKENHI-PROJECT-20380074
[Journal Article] Bacteroides induce higher IgA production than Lactobacillus by increasing activation-induced cytidine deaminase expression on B cells in murine peyer's patches.2009
- Author(s)
  Yanagibashi T., Hosono A., Oyama A., Tsuda M., Hachimura S., Takahashi Y., Itoh K., Hirayama K., Takahashi K., Kaminogawa S.
- Journal Title
  
  Biosci.Biotech.Biochem. 73
  
  Pages: 372-377
- NAID
  10027537465
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590501
[Journal Article] Protective immunity afforded by H5N1(NIBRG-14)-inactivated vaccine requires both antibodies against hemagglutinin and neuraminidase2009
- Author(s)
  Takahashi, et al.
- Journal Title
  
  J.Infect.Dis. 199
  
  Pages: 1629-1637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590501
[Journal Article] Protective immunity afforded by H5N1 (NIBRG-14)-inactivated vaccine requires both antibodies against hen-iagglutinin and neuraminidase in mice2009
- Author(s)
  Y. Takahashi et al.
- Journal Title
  
  J. Infect. Dis. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380074
[Journal Article] Bacteroides induce higher IgA production than Lactobacillus by increasing activation-induced cytidine deaminase expression on B cells in murine Peyer's patches.2009
- Author(s)
  Yanagibashi, T., Hosono, A., Oyama, T., Tsuda, M., Hachimura, S., Takahashi, Y., Itoh, K., Hirayama, K., Takahashi K., Kaminogawa, S.
- Journal Title
  
  Biosci.Biotechnol.Biochem. 73
  
  Pages: 372-377
- NAID
  10027537465
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380074
[Journal Article] Intestinal Bifidobacterium association in germ-free T cell receptor transgenic mice down-regulates dietary antigen-specific immune responses of the small intestine but enhances those of the large intestine.2009
- Author(s)
  Tsuda, M., Hosono, A., Yanagibashi,T., Hachimura S., Hirayama, K., Umesaki, Y., Itoh, K., Takahashi, K., Kaminogawa, S.
- Journal Title
  
  214
  
  Pages: 279-289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380074
[Journal Article] Protective immunity afforded by H5N1 (NIBRG-14)-inactivated vaccine requires both antibodies against hemagglutinin and neuraminidase.2009
- Author(s)
  Takahashi Y., Hasegawa H., Hara Y., Ato M., Ninomiya A., Takagi H., Odagiri T., Sata T., Tashiro M., Kobayashi K.
- Journal Title
  
  J.Infect.Dis. 199
  
  Pages: 1629-1637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590501
[Journal Article] Protective immunity afforded by H5N1 (NIBRG-14)-inactivated vaccine requires both antibodies against hemagglutinin and neuraminidase.2009
- Author(s)
  Takahashi, Y., Hasegawa, H., Hara, Y., Ato, M., Ninomiya, A., Takagi, H., Odagiri, T., Sata, T., Tashiro, M., Kobayashi, K.
- Journal Title
  
  J.Infect.Dis. 199
  
  Pages: 1629-1637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380074
[Journal Article] Suppressive effects ofBifidobacterium longum on the production of Th2-attracting chemokines induced with T cell-antigen-presenting cell interactions.2009
- Author(s)
  Iwabuchi, N., Takahashi, N., Xiao, J-Z., Yonezawa, S., Yaeshima, T., Iwatsuki, K., Hachimura, S.
- Journal Title
  
  FEMS Immunol.Med.Microbiol. 55
  
  Pages: 323-334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380074
[Journal Article] Protective immunity afforded by H5N1(NIBRG-14)-inactivated vaccine requires both antibodies against hemagglutinin and neuraminidase in mice.2009
- Author(s)
  Y.Takahashi, et al.
- Journal Title
  
  J.Infect. Dis. 199
  
  Pages: 1629-1637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20380074
[Journal Article] Memory B cells in systemic and mucosal immune response;Implications for successful vaccination2007
- Author(s)
  Takahashi, et. al.
- Journal Title
  
  Biosci.Biotech.Biochem 71
  
  Pages: 2358-2366
- NAID
  10027519391
- Data Source
  KAKENHI-PROJECT-18790350
[Journal Article] The agnathan lamprey diversifies antigen receptor genes by shifting junctions during gene rearrangement.2007
- Author(s)
  Nagawa, F., Kishishita, N., Shimizu, K., Hirose, S., Miyoshi, M., Nezu, J., Nishimura, T., Nishizumi, H., Takeuchi, M., Miyajima, A., Hashimoto, S., Takahashi, Y., Toshitada Takemori, T., Otsuka, A.-J., Sakano, H.
- Journal Title
  
  Nature Immunol. 8
  
  Pages: 206-213
- Data Source
  KAKENHI-PROJECT-16043261
[Journal Article] The agnathan lamprey diversifies antigen receptor genes by shifting junctions during gene rearrangemen2007
- Author(s)
  Nagawa, F., Kishishita, N., Shimizu, K., Hirose, S., Miyoshi, M., Nezu, J., Nishimura, T., Nishizumi, H., Takeuchi, M., Miyajima, A., Hashimoto, S., Takahashi, Y., Toshitada Takemori, T.Otsuka, A.-J., Sakano, H.
- Journal Title
  
  Nature Immunol. 8
  
  Pages: 206-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16043261
[Journal Article] B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts.2006
- Author(s)
  Hori, J., Wang, M., Miyashita, M., Tanemoto, K., Takahashi, H., Takemori, T., Okumura, K., Yagita, H., Azuma, M.
- Journal Title
  
  J. Immunol. 177
  
  Pages: 5928-5935
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16043261
[Journal Article] The agnathan lamprey diversifies antigenreceptor genes by shifting junctions during gene rearrangement.2006
- Author(s)
  Nagawa, F, Kishishita, N, Shimizu, K, Hirose, S, Miyoshi, M, Nezu, J, Nishimura, T, Nishizumi, H, Takeuchi, M, Miyajima, A, Hashimoto, S, Takahashi, Y, Toshitada Takemori, T, Otsuka, A.-J, Sakano, H.
- Journal Title
  
  Nature Immunol. 8
  
  Pages: 206-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16043261
[Journal Article] B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts2006
- Author(s)
  Hori, J., Wang, M., Miyashita, M., Tanemoto, K., Takahashi, H., Takemori, T., Okumura, K., Yagita, H., Azuma, M.
- Journal Title
  
  J. Immunol. 177
  
  Pages: 5928-5935
- Data Source
  KAKENHI-PROJECT-16043261
[Journal Article] A unique role of Ras in memory B cell response.2005
- Author(s)
  Takahashi, Y., Inamine A., Hashimoto, S.-I., Yoshioka, E., Kojima, N., Abe, R., Takemroi T
- Journal Title
  
  Immunity 23
  
  Pages: 127-138
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16043261
[Journal Article] A unique role of Ras in memory B cell response.2005
- Author(s)
  Takahashi, Y., Inamine A., Hashimoto, S.-I., Yoshioka, E., Kojima, N., Abe, R., Takemroi T.
- Journal Title
  
  Immunity 23
  
  Pages: 127-138
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390164
[Journal Article] A unique role of Ras in memory B cell response.2005
- Author(s)
  Takahashi, Y., et al.
- Journal Title
  
  Immunity 23
  
  Pages: 127-138
- Data Source
  KAKENHI-PROJECT-16043261
[Journal Article] Two waves of memory B cell generation in the primary immune response.2005
- Author(s)
  Inamine, A., Takahashi, Y., Tokuhisa, T., Miyae K., Takemori, T., Abe, R.
- Journal Title
  
  Int.Immunol. 17
  
  Pages: 581-589
- NAID
  10019359396
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390164
[Journal Article] A unique role of Ras in memory B cell response.2005
- Author(s)
  Takahashi, Y., et al.
- Journal Title
  
  Immunity 23
  
  Pages: 127-138
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390164
[Journal Article] Two waves of memory B cellgeneration in the primary immune response.2005
- Author(s)
  Inamine, A, Takahashi, Y, Tokuhisa, T, Miyae K, Takemori, T, Abe, R.
- Journal Title
  
  Int. Immunol. 17
  
  Pages: 581-589
- NAID
  10019359396
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16043261
[Journal Article] Two waves of memory B cell generation in the primary immune response.2005
- Author(s)
  Inamine, A., Takahashi, Y., Tokuhisa, T., Miyae K., Takemori, T., Abe, R.
- Journal Title
  
  Int. Immunol. 17
  
  Pages: 581-589
- NAID
  10019359396
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16043261
[Journal Article] B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts.2005
- Author(s)
  Hori, J, Wang, M, Miyashita, M, Tanemoto, K, Takahashi, H, Takemori, T, Okumura, K, Yagita, H, Azuma, M.
- Journal Title
  
  J. Immunol. 177
  
  Pages: 5928-5935
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16043261
[Journal Article] A unique role of Ras in memoryB cell response.2005
- Author(s)
  Takahashi, Y, Inamine A, Hashimoto, S.-I, Yoshioka, E, Kojima, N, Abe, R, Takemroi T.
- Journal Title
  
  Immunity 23
  
  Pages: 127-138
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16043261
[Journal Article] An essentialrole for the RNA-pr b GANP for somatic hypermu tation of immunoglobulin gene in germinal center B cells.2004
- Author(s)
  Kuwahara, K, Fujita, S, Takahashi, Y, Xing, Y, Nakagata, N, Takemori, T, Aizawa, S, Sakaguchi, N.
- Journal Title
  
  Pric, Natl. Acad. Sci. USA 101
  
  Pages: 1010-1015
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16043261
[Journal Article] An essential role for the RNA-pr b GANP for somatic hypermutation of immunoglobulin gene in germinal center B cells.2004
- Author(s)
  Kuwahara, K., Fujita, S., Takahashi, Y., Xing, Y Nakagata, N., Takemori, T., Aizawa, S.Sakaguchi, N.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 101
  
  Pages: 1010-1015
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16043261
[Journal Article] Isotype-specific selection of high affinity memory B cells in nasal-associated lymphoid tissue.
- Author(s)
  Shimoda M, Nakamura T, Takahashi Y, Asanuma H, Tamura S, Kurata T, Mizuochi T, Azuma N, Kanno C, Takemori T
- Journal Title
  
  J Exp Med. (submitted)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-11670332
[Presentation] Humoral immune memory elicited by COVID-19 vaccine.2024
- Author(s)
  Yoshimasa Takahashi
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology.
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] Understanding humoral immunity by multi-disciplinary approach2024
- Author(s)
  Yoshimasa Takahashi
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] Vaccine-elicited memory B-cell responses for tackling virus variants2024
- Author(s)
  Yoshimasa Takahashi
- Organizer
  The 37th Meeting of the USJCMSP Hepatitis Panel
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] ヒト液性免疫記憶の統合的理解に向けたプロファイリング研究2023
- Author(s)
  高橋宜聖
- Organizer
  令和4年度「感染・免疫・がん・炎症」全国共同研究拠点シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] COVID-19ワクチンの有効性を免疫学的に評価する2023
- Author(s)
  高橋宜聖
- Organizer
  第97回日本感染症学会総会・学術講演会　第71回日本化学療法学会学術集会合同学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] Human immune profiling for vaccine and immunotherapeutic design2023
- Author(s)
  Yoshimasa Takahashi
- Organizer
  Hwasun International Vaccine and Immunotherapy Forum 2023
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] Humoral immune memory to mutating viruses International Symposium for Future Mucosal Vaccines2023
- Author(s)
  Yoshimasa Takahashi.
- Organizer
  Safeguards and Innovations against Infectious Diseases
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] Immune profiling for understanding vaccine immunogenicity and reactogenicity2023
- Author(s)
  高橋宜聖
- Organizer
  第97回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] SARS-CoV-2から教えられた免疫の適応力2023
- Author(s)
  高橋宜聖
- Organizer
  第97回日本感染症学会総会・学術講演会　第71回日本化学療法学会学術集会合同学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] 免疫記憶の形成ーワクチン反応研究からのフイードバック2023
- Author(s)
  高橋宜聖
- Organizer
  第67回日本リウマチ学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] これから求められる臨床評価（免疫学に基づくワクチン有用性／安全性評価）2022
- Author(s)
  高橋宜聖
- Organizer
  第26回日本ワクチン学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] 免疫の不思議からヒントをえる制御技術2022
- Author(s)
  高橋宜聖
- Organizer
  第38回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] Evolution of humoral immunity to mutating viruses2022
- Author(s)
  高橋宜聖
- Organizer
  第20回あわじ感染と免疫国際フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] ワクチン有効性・安全性の基盤となる免疫応答2022
- Author(s)
  高橋宜聖
- Organizer
  第42回阿蘇シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] 変異するウイルスに対抗する抗体の適応戦略2022
- Author(s)
  高橋宜聖
- Organizer
  千里ライフサイエンスセミナーT3「感染症における免疫制御機構」
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] SARS-CoV-2に対する免疫の特性2022
- Author(s)
  高橋宜聖
- Organizer
  第35回インフルエンザ研究者交流の会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] Interleukin-27 supports metabolic adaptation of Natural killer T cells and effector responses2022
- Author(s)
  Yasuhiro Kamii, Koji Hayashizaki, Toshio Kanno, Yoshimasa Takahashi, Toshiaki Ohteki, Yusuke Endo, Yuki Kinjo
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24382
[Presentation] SARS-CoV-2 immunity and therapeutics2021
- Author(s)
  高橋宜聖
- Organizer
  環太平洋新興・再興感染症国際会議（Emerging Infectious Diseases 国際会議）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] NKT-mediated vaccine induces affinity maturation of BCR and supply antibody dependent protection against Streptococcus pneumoniae2021
- Author(s)
  Hayashizaki K, Takatsuka S, Kamii Y, Tsuiji M, Kubo M, Takahashi Y, Kinjo Y
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03705
[Presentation] Gr-1+ cells influence on the differentiation of follicular helper Natural killer T cells2021
- Author(s)
  Kamii Y, Hayashizaki K, Kanno T, Endo Y, Takahashi Y, Kinjo Y
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03705
[Presentation] 万能インフルエンザワクチンの創出研究2020
- Author(s)
  高橋宜聖
- Organizer
  医療分野研究成果展開事業産学連携医療イノベーション創出プログラム（ACT-M/MS）第３回成果発表会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07545
[Presentation] 小腸パイエル板細胞によるIgA産生応答における腸内細菌及びレチノイン酸による修飾作用2017
- Author(s)
  石井涼太，石井俊祐，津田真人，高橋恭子，八村敏志，細野朗，上野川修一
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-26292065
[Presentation] Regulation of antibody breadth to mutating viruses through distinct germinal center selection.2017
- Author(s)
  Takahashi, Y., Adachi, Y., Onodera, T., Ato, M.
- Organizer
  The 16th Awaji International Forum on Infection and Immunity
- Invited
- Data Source
  KAKENHI-PROJECT-16K15296
[Presentation] Induction of broadly-protective B cell responses to mutating viruses.2017
- Author(s)
  Takahashi, Y.
- Organizer
  第46回日本免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-16K15296
[Presentation] Influenza hemagglutinin epitopes emerging at viral replication sites promote the clonal selection and plasma cell development of broadly protective B cells.2017
- Author(s)
  Adachi, Y., Nithichanon, A., Kuraoka, M., Kelsoe, G., Ato, M., Takahashi, Y.
- Organizer
  Keystone symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15296
[Presentation] 結腸リンパ節におけるT細胞分化の特徴．2017
- Author(s)
  石濱史也，津田真人，小熊俊生，村木悠平，於鉄崢，八村敏志，高橋宜聖，高橋恭子，上野川修一，細野朗
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-26292065
[Presentation] 大腸リンパ節特徴的に存在する自然リンパ球の解析2017
- Author(s)
  畑井俊哉,上滝隆太郎,津田真人,高橋恭子,細野朗,八村敏志
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-26292065
[Presentation] 大腸リンパ組織における制御性T細胞の特性と腸内細菌による影響2016
- Author(s)
  石濱史也, 津田真人, 八村敏志, 高橋宜聖, 高橋恭子, 上野川修一, 細野朗
- Organizer
  日本食品免疫学会2016年度大会
- Place of Presentation
  東京大学（東京）
- Year and Date
  2016-11-09
- Data Source
  KAKENHI-PROJECT-26292065
[Presentation] Broadly cross-reactive human memory B cells against norovirus express dual B cell antigen receptors.2016
- Author(s)
  Onodera T, Ato M, Takahashi T
- Organizer
  日本免疫学会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-16K15296
[Presentation] 腸管関連リンパ組織 (GALT) における自然リンパ球 (ILCs) 応答性の組織特異性解析：大腸・小腸免疫系の比較2016
- Author(s)
  畑井俊哉, 上滝隆太郎, 津田真人，高橋恭子, 細野朗，八村敏志
- Organizer
  日本食品免疫学会2016年度大会
- Place of Presentation
  東京大学（東京）
- Year and Date
  2016-11-09
- Data Source
  KAKENHI-PROJECT-26292065
[Presentation] Follicular helper NKT cells induce protective effect of a protein-based pneumococcal vaccine through stimulation of IgG production by B cells.2016
- Author(s)
  Nakahara M, Takatsuka S, Ueno K, Onodera T, Takahashi Y, Kawakami K, Kubo M, Kinjo Y
- Organizer
  日本免疫学会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-16K15296
[Presentation] パイエル板樹状細胞はT細胞のIL-21遺伝子発現を誘導する2016
- Author(s)
  上滝隆太郎、糸賀翔大、石井俊祐、輪島隼一、芝原恭子、高橋恭子、上野川修一、細野朗、八村敏志
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター（北海道）
- Year and Date
  2016-03-30
- Data Source
  KAKENHI-PROJECT-26292065
[Presentation] Different accessibility of strain-specific versus cross-reactive BCRs to virus particles regulates site-specific germinal center selection.2016
- Author(s)
  Adachi Y, Ato M, Takahashi Y
- Organizer
  日本免疫学会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-16K15296
[Presentation] 腸管関連リンパ組織における自然リンパ球の解析2015
- Author(s)
  上滝隆太郎、畑井俊哉、高橋宜聖、橋口昌章、辻典子、山田潔、戸塚護、上野川修一、細野朗、八村敏志
- Organizer
  日本食品免疫学会2015年度大会
- Place of Presentation
  東京大学（東京）
- Year and Date
  2015-10-15
- Data Source
  KAKENHI-PROJECT-26292065
[Presentation] 腸管関連リンパ組織における濾胞ヘルパーT細胞についての解析2015
- Author(s)
  上滝隆太郎、於鉄崢、糸賀翔大、畑井俊哉、石井俊祐、輪島隼一、芝原恭子、高橋恭子、上野川修一、細野朗、八村敏志
- Organizer
  第19回腸内細菌学会
- Place of Presentation
  北里大学（東京）
- Year and Date
  2015-06-18
- Data Source
  KAKENHI-PROJECT-26292065
[Presentation] Protective memory B cell responses to influenza virus infection2011
- Author(s)
  Takahashi, Y
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-21229007
[Presentation] Protective memory B cells against influenza virus infection in the lungs2010
- Author(s)
  高橋宜聖
- Organizer
  千葉大学G-COEシンポジウム
- Place of Presentation
  東京都千代田区東京ステーションコンファレンス
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-20590501
[Presentation] Protective memory B cells against influenza virus infection in the lungs.2010
- Author(s)
  高橋宜聖
- Organizer
  千葉大G-COEシンポジウム(Development and maintenance of immunememory)
- Place of Presentation
  東京
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-20590501
[Presentation] ヒト血清移入マウスを用いたインフルエンザウイルス感染防御能の解析2009
- Author(s)
  高橋宜聖
- Organizer
  日本ワクチン学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2009-09-27
- Data Source
  KAKENHI-PROJECT-20590501
[Presentation] ヒト血清抗体・細胞移入マウスを用いた防御免疫評価系の構築2009
- Author(s)
  高橋宜聖
- Organizer
  日本食品免疫学会
- Place of Presentation
  東京大学
- Year and Date
  2009-05-26
- Data Source
  KAKENHI-PROJECT-20590501
[Presentation] ヒト血清移入マウスを用いたインフルエンザウイルス感染防御能の解析2009
- Author(s)
  高橋宜聖
- Organizer
  第13回日本ワクチン学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2009-09-27
- Data Source
  KAKENHI-PROJECT-20590501
[Presentation] インフルエンザウイルスの感染防御に寄与するメモリーB細胞の同定2009
- Author(s)
  高橋宜聖
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20590501
[Presentation] バクテロイデスは胚中心の形成を促すことで大腸のIgA産生を強く誘導する2008
- Author(s)
  高橋宜聖
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20590501
[Presentation] IgA+ memory B cells persist in the lung after an intranasal infection with influenza virus.2008
- Author(s)
  高橋宜聖
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20590501
[Presentation] H5N1(NIBRG-14)ワクチンの感染防御効果には、抗ヘマグルチニン抗体と抗ノイラミニダーゼ抗体の両者が関与する2008
- Author(s)
  高橋宜聖
- Organizer
  第12回日本ワクチン学会学術集会
- Place of Presentation
  熊本
- Year and Date
  2008-11-08
- Data Source
  KAKENHI-PROJECT-20590501
[Presentation] ワクチンの感染防御効果には、抗ヘマグルチニン抗体と抗ノイラミニダーゼ抗体の両者が関与する2008
- Author(s)
  高橋宜聖
- Organizer
  日本ワクチン学会
- Place of Presentation
  熊本
- Year and Date
  2008-11-08
- Data Source
  KAKENHI-PROJECT-20590501
[Presentation] IgA+ memory B cells persist in the lung after an intranasal infection with influenza virus2008
- Author(s)
  高橋宜聖
- Organizer
  日本免疫学会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20590501
[Presentation] H5N1型プレパンデミックワクチンによる感染防御メカニズムの解析2007
- Author(s)
  高橋宜聖
- Organizer
  日本ウイルス学会
- Place of Presentation
  札幌
- Year and Date
  2007-10-23
- Data Source
  KAKENHI-PROJECT-18790350
[Presentation] H5N1インフルエンザワクチンが惹起する防御抗体はウイルス申和に補体因子を必要とする2007
- Author(s)
  高橋宜聖
- Organizer
  日本免疫学会
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-18790350
[Presentation] Selective affinity maturation of IgA+B cells in mucosal germinal centers2000
- Author(s)
  Takahashi Y, Shimoda M, Takemori T
- Organizer
  Keystone Symposia, Innate and Acquire Immunity at Mucosal Surfaces
- Place of Presentation
  Taos NM
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-11670332
[Presentation] Selective affinity maturation of IgA+B cells in mucosal germinal centrs.2000
- Author(s)
  Takahashi,Y
- Organizer
  Keystone Symposia, Innate and Acquired Immunity at Mucosal Surfaces
- Place of Presentation
  Taos, NM
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-11670332

1. TOSHITADA Takemori (60114295)

# of Collaborated Projects: 10 results

# of Collaborated Products: 13 results
2. HASHIMOTO Shuichi (60342896)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
3. HACHIMURA Satoshi (40238019)

# of Collaborated Projects: 4 results

# of Collaborated Products: 16 results
4. 藤猪英樹 (50356250)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
5. OSHIMA Kenshuro (40537411)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. NAGAWA Fumikiyo (10241233)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. NAKAJIMA Haruyo (20595962)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. KAJI Tomohiro (70370963)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. HOSONO Akira (70328706)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
10. Kinjo Yuki (20570831)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
11. 林崎浩史 (50779907)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
12. 高塚翔吾 (90609398)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
13. KUROSAKI Tomohiro (50178125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
14. BABA Yoshihiro (20415269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAKAYAMA Jiro (40217930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAMURA Shinichi (20100084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. OHARA Osamu (20370926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HIKITA Masaki (60228715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. Onodera Taishi (90513143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
20. 横田恭子 (20182701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 大西和夫 (90169011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 大島正道 (10272428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 高須賀直美 (70203297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 常彬 (50370961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TAKAHASHI Kyoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
26. 久保允人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 上野川修一

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
28. 福山英啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 中山俊憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 岩倉洋一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Yoshimasa 高橋 宜聖

TAKAHASHI Yoshimasa 高橋 宜聖

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インフルエンザ交差反応性抗体の選択と防御メカニズムの解明Principal Investigator

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Regulation of influenza protective antibody responses by microbiotaPrincipal Investigator

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Functional analysis of memory B cells in lungsPrincipal Investigator

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メモリーB細胞の最終分化を促進する分子メカニズムの解析Principal Investigator

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Takahashi Yoshimasa 高橋宜聖

TAKAHASHI Yoshimasa 高橋宜聖