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Araki Wataru  荒木 亘

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… Alternative Names

ARAKI Wataru  荒木 亘

荒本 亘  アラキ ワタル

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Researcher Number 60311429
Other IDs
Affiliation (Current) 2025: 東京科学大学, その他の部局等, 非常勤講師
Affiliation (based on the past Project Information) *help 2019 – 2021: 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師
2018: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第六部, 研究員
2017: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所, 室長
2016: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第六部, 室長
2015: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第6部, 室長 … More
2015: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第六部, 室長
2012 – 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第6部, 室長
2012: 独立行政法人国立精神・神経医療研究センター, 神経研究所 疾病研究第六部, 室長
2011: (財)国立精神・神経医療研究センター, 神経研究所・疾病研究第六部, 室長
2010: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第六部, 室長
2008: National Center of Neurology and Psychiatry, 神経研究所疾病研究第六部, 室長
2007 – 2008: National Center of Neurology and Psychiatry, 神経研究所・疾病研究第六部, 室長
2004: 国立精神・神経センター, 神経研究所・疫病研究第6部, 室長
2002 – 2004: Dept. Demyelinating Dis. &Aging Chief, 疾病研究第6部, 室長
2002 – 2004: 国立精神・神経センター, 神経研究所, 室長
2001: 国立精神・神経センター, 神経研究所・6部, 室長
2001: 国立精神・神経センター, 神経研究所・疾病6部, 室長
2000: 国立精神・神経センター, 神経研究所・疾病研究第6部, 室長 Less
Review Section/Research Field
Principal Investigator
Neurology / Basic Section 51030:Pathophysiologic neuroscience-related / Neurology
Except Principal Investigator
Biological Sciences
Keywords
Principal Investigator
アルツハイマー病 / 認知症 / オリゴマー / βセクレターゼ / アミロイド / シナプス / アミロイドβ / βアミロイド / プロテアーゼ / アミロイドβタンパク質 … More / 受容体 / 神経毒性 / グルタミン酸受容体 / アルツハイマー / protease / amyloid β-protein / Alzheimer's disease / アミロイドβタンパク / neurodegenerative disorder / α-synuclein / 神経変性疾患 / α-シヌクレイン / 脳神経疾患 / BACE1 / セクレターゼ / LRP1 / 脂質ラフト / プロテアーぜ … More
Except Principal Investigator
AB-DIP / adoplin / aging / neprilysin / glypican 1 / apoptosis / β amyloid / Alzheimer's disease / Alzheimer / LIM / DRAL / APP / PS2 / PS1 / ラフト / グリピカン / β蛋白 / アミロイド / エービーティップ / アドプリン / 老化 / ネプリライシン / グリピカン1 / アポトーシス / βアミロイド / アルツハイマー病 Less
  • Research Projects

    (8 results)
  • Research Products

    (84 results)
  • Co-Researchers

    (27 People)
  •  Elucidation of the synapse pathology of Alzheimer's disease with a focus on the receptors which bind amyloid-beta oligomersPrincipal Investigator

    • Principal Investigator
      ARAKI WATARU
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Molecular mechanisms of BACE1 dysregulation and synaptic degeneration in Alzheimer's diseasePrincipal Investigator

    • Principal Investigator
      ARAKI WATARU
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Elucidation of the pathological upregulation of beta-secretase and its molecular regulationPrincipal Investigator

    • Principal Investigator
      Araki Wataru
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  A study toward development of novel Alzheimer therapies based on the regulation ofβ-secretase functionPrincipal Investigator

    • Principal Investigator
      ARAKI Wataru
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Elucidation of the regulation mechanisms of activity, expression and cellular localization of β-secretase in neuronal cellsPrincipal Investigator

    • Principal Investigator
      ARAKI Wataru
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Analysis of the regulation mechanism of β-secretase functionPrincipal Investigator

    • Principal Investigator
      ARAKI Wataru
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Institute of Neuroscience, NCNP
  •  A study on the mechanism of α-synuclein deposition: Is a novel α-synuclein interacting protein involved in α-synucleinopathies?Principal Investigator

    • Principal Investigator
      ARAKI Wataru
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      National Institute of Neuroscience, NCNP
  •  Identification of aging-related factors that facilitate Alzheimer's disease

    • Principal Investigator
      TABIRA Takeshi
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      NATIONAL INSTITUTE FOR LONGEVITY SCIENCES
      National Center of Neurology and Psychiatry

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005 2004 Other

All Journal Article Presentation Book Patent

  • [Book] アルツハイマー病 発症メカニズムと新規診断法・創薬・治療開発2018

    • Author(s)
      荒木亘,荒木由美子
    • Total Pages
      7
    • Publisher
      エヌ・ティー・エス
    • Data Source
      KAKENHI-PROJECT-16K09688
  • [Book] Recent advances in the biology of secretases, key proteases in Alzheimer's disease2008

    • Author(s)
      Araki W
    • Publisher
      Research Signpost
    • Data Source
      KAKENHI-PROJECT-19591025
  • [Book] Regulation mechanisms of beta-secretase activity. In Recent advances in the biology of secretases, key proteases in Alzheimer's disease. (Eds. Araki W)2008

    • Author(s)
      Araki W
    • Publisher
      Research Signpost, Kerala
    • Data Source
      KAKENHI-PROJECT-19591025
  • [Journal Article] Protection against Amyloid-β Oligomer Neurotoxicity by Small Molecules with Antioxidative Properties: Potential for the Prevention of Alzheimer’s Disease Dementia2022

    • Author(s)
      Araki Wataru、Kametani Fuyuki
    • Journal Title

      Antioxidants

      Volume: 11 Issue: 1 Pages: 132-132

    • DOI

      10.3390/antiox11010132

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07836
  • [Journal Article] Amyloid-β oligomers interact with NMDA receptors containing GluN2B subunits and metabotropic glutamate receptor 1 in primary cortical neurons: Relevance to the synapse pathology of Alzheimer’s disease2022

    • Author(s)
      Taniguchi Kaori、Yamamoto Fumiko、Amano Akiko、Tamaoka Akira、Sanjo Nobuo、Yokota Takanori、Kametani Fuyuki、Araki Wataru
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 90-98

    • DOI

      10.1016/j.neures.2022.03.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07836
  • [Journal Article] Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE12021

    • Author(s)
      Komaki Keisuke、Takano Tetsuya、Sato Yutaka、Asada Akiko、Ikeda Shikito、Yamada Kaoru、Wei Ran、Huo Anni、Fukuchi Aoi、Saito Taro、Ando Kanae、Murayama Shigeo、Araki Wataru、Kametani Fuyuki、Hasegawa Masato、Iwatsubo Takeshi、Tomomura Mineko、Fukuda Mitsunori、Hisanaga Shin-ichi
    • Journal Title

      The Journal of Biochemistry

      Volume: 170 Issue: 6 Pages: 729-738

    • DOI

      10.1093/jb/mvab094

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07836, KAKENHI-PROJECT-19K06942, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-22K07550, KAKENHI-PROJECT-22K11708, KAKENHI-PROJECT-19K07988, KAKENHI-PROJECT-22H04923
  • [Journal Article] Tyrosol reduces amyloid-β oligomer neurotoxicity and alleviates synaptic, oxidative, and cognitive disturbances in Alzheimer's disease model mice2019

    • Author(s)
      Taniguchi K, Yamamoto F, Arai T, Yang J, Sakai Y, Itoh M, Mamada N, Sekiguchi M, Yamada D, Saitoh A, Kametani F, Tamaoka A, Araki YM, Wada K, Mizusawa H, Araki W
    • Journal Title

      J Alzheimer’s Dis

      Volume: 70 Issue: 3 Pages: 937-952

    • DOI

      10.3233/jad-190098

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07836
  • [Journal Article] TFEB-mediated Enhancement of the Autophagy-lysosomal Pathway Dually Modulates the Process of Amyloid β-Protein Generation in Neurons.2019

    • Author(s)
      Yamamoto F, Taniguchi K, Mamada N, Tamaoka A, Kametani F, Lakshmana MK, Araki W.
    • Journal Title

      Neuroscience. 2

      Volume: 402 Pages: 11-22

    • DOI

      10.1016/j.neuroscience.2019.01.010

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09664, KAKENHI-PROJECT-16K09681, KAKENHI-PROJECT-16K09688
  • [Journal Article] The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model.2017

    • Author(s)
      Tanokashira D, Mamada N, Yamamoto F, Taniguchi K, Tamaoka A, Lakshmana MK, Araki W
    • Journal Title

      Mol Brain

      Volume: 10 Issue: 1 Pages: 4-4

    • DOI

      10.1186/s13041-016-0284-5

    • NAID

      120007135045

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09688, KAKENHI-PROJECT-16K09664
  • [Journal Article] Mitochondoria are devoid of amyloid beta-protein (Abeta)-producing secretases: Evidence for unlikely occurrence within mitochondria of Abeta generation from amyloid precursor protein.2017

    • Author(s)
      Naomi Mamada, Daisuke Tanokashira, Kazuhiro Ishii, Akira Tamaoka, Wataru Araki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 486 Issue: 2 Pages: 321-328

    • DOI

      10.1016/j.bbrc.2017.03.035

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09664, KAKENHI-PROJECT-16K09688
  • [Journal Article] Reversibility of Aβ oligomer neurotoxicity2017

    • Author(s)
      Araki Wataru
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 31 Pages: 50335-50336

    • DOI

      10.18632/oncotarget.19083

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09688
  • [Journal Article] Post-translational regulation of the β-secretase BACE12016

    • Author(s)
      Araki W
    • Journal Title

      Brain Research Bulletin

      Volume: 未定 Pages: 170-177

    • DOI

      10.1016/j.brainresbull.2016.04.009

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25461300, KAKENHI-PROJECT-16K09688
  • [Journal Article] Amyloid beta-protein and lipid rafts: focused on biogenesis and catabolism.2015

    • Author(s)
      Araki W, Tamaoka A
    • Journal Title

      Front Biosci (Landmark Ed)

      Volume: 20 Issue: 2 Pages: 314-324

    • DOI

      10.2741/4311

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25461300
  • [Journal Article] Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons.2015

    • Author(s)
      Mamada N, Tanokashira D, Hosaka A, Kametani F, Tamaoka A, Araki W
    • Journal Title

      Molecular Brain

      Volume: 8 Issue: 1 Pages: 73-73

    • DOI

      10.1186/s13041-015-0163-5

    • NAID

      120007135795

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25461300
  • [Journal Article] Potential repurposing of oncology drugs for the treatment of Alzheimer's disease2013

    • Author(s)
      Araki W
    • Journal Title

      BMC Medicine

      Volume: 11 Issue: 1 Pages: 82-82

    • DOI

      10.1186/1741-7015-11-82

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Journal Article] Statins reduce amyloid β-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons2013

    • Author(s)
      Hosaka A, Araki W, Oda A, Tomidokoro Y, Tamaoka A
    • Journal Title

      Neurochem Res

      Volume: 38 Issue: 3 Pages: 589-600

    • DOI

      10.1007/s11064-012-0956-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590951, KAKENHI-PROJECT-24591249
  • [Journal Article] Reduction of β-amyloid accumulation by reticulon 3 in transgenic mice2013

    • Author(s)
      Araki W, Oda A, Motoki K, Hattori K, Itoh M, Yuasa S, Konishi Y, Shin R-W, Tamaoka A, Ogino K
    • Journal Title

      Curr Alzheimer Res

      Volume: 10 Issue: 2 Pages: 135-142

    • DOI

      10.2174/1567205011310020003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Journal Article] Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: Analysis with a palmitoylation-deficient mutant2012

    • Author(s)
      Motoki K, Kume H, Oda A, Tamaoka A, Hosaka A, Kametani F, Araki W
    • Journal Title

      Brain and Behavior

      Volume: 2 Issue: 3 Pages: 270-282

    • DOI

      10.1002/brb3.52

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590951, KAKENHI-PROJECT-24591249
  • [Journal Article] MEK inhibitors suppress beta-amyloid production by altering the level of a beta-C-terminal fragment of amyloid precursor protein in neuronal cells2010

    • Author(s)
      Araki W, 他3名
    • Journal Title

      FEBS Letters

      Volume: 584 Pages: 3410-3414

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Journal Article] IGF-1 promotes beta-amyloid production by a secretase-independent mechanism2009

    • Author(s)
      Araki W, 他4名
    • Journal Title

      Biochem. Biophys. Res. Commun. 380

      Pages: 111-114

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591025
  • [Journal Article] IGF-1 promotes beta-amyloid production by a secretase-independent mechanism. Biochem.2009

    • Author(s)
      Araki W, Kume H, Oda A, Tamaoka A, Kametani F
    • Journal Title

      Biophys. Res. Commun. 380

      Pages: 111-114

    • Data Source
      KAKENHI-PROJECT-19591025
  • [Journal Article] The two-hydrophobic domain tertiary structure of reticulon proteins is critical for modulation of β-secretase BACE1.2009

    • Author(s)
      Kume H, Murayama KS, Araki W
    • Journal Title

      J. Neurosci. Res. In press

      Pages: 0-0

    • Data Source
      KAKENHI-PROJECT-19591025
  • [Journal Article] Expression of reticulon 3 in Alzheimer's disease brain.2009

    • Author(s)
      Kume H, Konishi Y, Murayama KS, Kametani F, Araki W
    • Journal Title

      Neuropathol. Appl. Neurobiol. 35

      Pages: 178-188

    • Data Source
      KAKENHI-PROJECT-19591025
  • [Journal Article] アルツハイマー病と脂質ラフト2008

    • Author(s)
      荒木 亘, 織田彰子
    • Journal Title

      鳥取臨床科学研究会誌 1

      Pages: 143-1511

    • NAID

      40017043679

    • Data Source
      KAKENHI-PROJECT-19591025
  • [Journal Article] アルツハイマー病と脂質ラフト2008

    • Author(s)
      荒木亘, 他1名
    • Journal Title

      鳥取臨床科学研究会誌 1

      Pages: 143-151

    • NAID

      40017043679

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591025
  • [Journal Article] A family of membrane proteins associated with presenilin expression and gamma-secretase function.2008

    • Author(s)
      Araki W, Takahashi-Sasaki N, Chui DH, Saito S, Takeda K, Shirotani K, Takahashi K, Murayama KS, Kametani F, Shiraishi H, Komano H, Tabira T
    • Journal Title

      FASEB J. 22

      Pages: 819-827

    • Data Source
      KAKENHI-PROJECT-19591025
  • [Journal Article] A family of membrane proteins associated with presenilin.exnr'ession and gamma-secretase function2008

    • Author(s)
      Araki W., 他
    • Journal Title

      FASEB Journal 22

      Pages: 819-827

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591025
  • [Journal Article] A novel death-inducing protein, AB-DIP interacts with amyloid beta protein and mediates its neurotoxicity.2005

    • Author(s)
      Lakshmana MK, Araki W, Tabira T
    • Journal Title

      FASEB J (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12210021
  • [Journal Article] Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleavedamyloidprecursorproteinisdeposited Alzmimer's disease brain.2004

    • Author(s)
      Takeda K, Araki W, Akiyama H, Tabira T
    • Journal Title

      FASEB J 18

      Pages: 1755-1757

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12210021
  • [Journal Article] Glypican-1 as an Aβ binding HSPG in the human brain : its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease.2004

    • Author(s)
      Watanabe N, Araki W, Chui DH, Makibuchi T, Ihara Y, Tabira T.
    • Journal Title

      FASEB J 18

      Pages: 1013-1015

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210021
  • [Journal Article] Glypican-1 as an Aβ binding HSPG in the human brain : its localization in DIG domains and possible roles in the pathogens is of Alzheimer's disease.2004

    • Author(s)
      Watanabe N, Araki W, Chui DH, Makibuchi T, Ihara Y, Tabira T.
    • Journal Title

      FASEB J 18

      Pages: 1013-1015

    • Data Source
      KAKENHI-PROJECT-12210021
  • [Journal Article] Analysis of the secretion mechanism of beta-secretases.2004

    • Author(s)
      Murayama K, Kametani F, Takahashi N, Saito S, Araki W
    • Journal Title

      Neurobiology of Aging 25(S2)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590923
  • [Journal Article] Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain.2004

    • Author(s)
      Takeda K, Araki W, Akiyama H, Tabira T.
    • Journal Title

      FASEB J 18

      Pages: 1755-1757

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210021
  • [Journal Article] Analysis of the secretion mechanism of beta-secretases.2004

    • Author(s)
      Murayama K, Kametani T, Takahashi N, Saito S, Araki W
    • Journal Title

      Neurobiology of Aging 25,S2

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590923
  • [Journal Article] Analysis of the secretion mechanism of beta-secretases.2004

    • Author(s)
      Maruyama K, Kametani F, Takahashi N, Saito S, Araki W
    • Journal Title

      Neurobiology of Aging 25,S2

    • Data Source
      KAKENHI-PROJECT-15590923
  • [Journal Article] Glypican-1 as an Aβ binding HSPG in the human brain : its localization in DIG domains and possible roles in the pathogens is of Alzheimer's disease.2004

    • Author(s)
      Watanabe N, Araki W, Chui DH, Makibuchi T, Ihara Y, Tabira T
    • Journal Title

      FASEB J 18

      Pages: 1013-1015

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12210021
  • [Journal Article] A novel death-inducing protein, AB-DIP interacts with amyloid beta protein and mediates its neurotoxicity.

    • Author(s)
      Lakshmana MK, Araki W, Tabira T.
    • Journal Title

      FASEB J (inpress)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210021
  • [Patent] A composition for prevention and/or treatment for Alzheimer’s disease and/or Alzheimer dementia, and composition for reducing amyloid-beta oligomer neurotoxicity2020

    • Inventor(s)
      Wataru Araki, Jinwei Yang
    • Industrial Property Rights Holder
      Wataru Araki
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19K07836
  • [Patent] Adoplinタンパク質、およびその利用2005

    • Inventor(s)
      荒木 亘, 田平 武
    • Industrial Property Rights Holder
      (財)ヒューマンサイエンス振興財団
    • Industrial Property Number
      2005-026405
    • Filing Date
      2005-02-02
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12210021
  • [Patent] AB-DIP、並びにアルヅハイマー病の予防及び治療剤2004

    • Inventor(s)
      田平 武, 荒木亘, マデパリ・ケイ・ラクシュマナ
    • Industrial Property Rights Holder
      (財)ヒューマンサイエンス振興財団
    • Industrial Property Number
      2004-367780
    • Filing Date
      2004-12-20
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12210021
  • [Presentation] ナノミセル内包型抗Aβオリゴマー抗体によるアルツハイマー病態改善効果2021

    • Author(s)
      天野晶子,三條伸夫,安楽泰孝,中木戸誠,松原悦朗,永田哲也,西田陽一郎,荒木亘,津本浩平,片岡一則,横田隆徳
    • Organizer
      第40回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07836
  • [Presentation] アルツハイマー病態と膜ラフト2019

    • Author(s)
      荒木亘
    • Organizer
      第60回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-19K07836
  • [Presentation] Amyloid beta-protein oligomers bind to both NMDA receptor and metabotropic glutamate receptor 12019

    • Author(s)
      Araki W, Taniguchi K, Yamamoto F, Arai T, Kametani F, Tamaoka A
    • Organizer
      第60回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-19K07836
  • [Presentation] Enhancement of the autophagy-lysosomal pathway modulates the process of amyloid β-protein generation2018

    • Author(s)
      Araki W, Yamamoto F, Taniguchi K, Mamada N, Tamaoka A, Kametani F, Lakashmana MK
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09688
  • [Presentation] Enhancement of the autophagy-lysosomal pathway modulates the process of beta-amyloid generation2018

    • Author(s)
      Yamamoto F, Taniguchi K, Mamada N, Tamaoka A, Kametani F, Lakashmana MK, Araki W
    • Organizer
      第59回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16K09688
  • [Presentation] Soluble Aβ oligomers induce disorganization of synapses in primary cultured neurons.2017

    • Author(s)
      Taniguchi K, Yamamoto F, Mamada N, Tamaoka A, Araki W
    • Organizer
      ConBio2017
    • Data Source
      KAKENHI-PROJECT-16K09688
  • [Presentation] The reversibility of the neurotoxicity induced by amyloid β-protein oligomers.2017

    • Author(s)
      Araki W, Tanokashira D, Mamada N, Yamamoto F, Taniguchi K, Tamaoka A, Lakshmana MK
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール
    • Data Source
      KAKENHI-PROJECT-16K09688
  • [Presentation] オートファジー-リソソーム経路の促進のアミロイドβタンパク質産生過程への影響2017

    • Author(s)
      山本詞子,谷口香織,儘田直美,玉岡 晃,Madepalli K. Lakshmana,荒木 亘
    • Organizer
      第36回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K09688
  • [Presentation] Amyloid beta oligomers induce BACE1 augmentation in the neuritic compartment of neurons.2016

    • Author(s)
      Mamada N, Araki W, Tanokashira D, Kametani F, Tamaoka A
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター
    • Data Source
      KAKENHI-PROJECT-16K09688
  • [Presentation] The neurotoxicity of amyloid β-protein oligomers is reversible in nature.2016

    • Author(s)
      Araki W, Tanokashira D, Mamada N, Yamamoto F, Tamaoka A, Lakshmana MK
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-16K09688
  • [Presentation] アミロイドβオリゴマーによるBACE1発現増強のメカニズム2015

    • Author(s)
      儘田直美,田之頭大輔,保坂 愛,玉岡 晃,亀谷富由樹,荒木 亘
    • Organizer
      第34回日本認知症学会学術集会
    • Place of Presentation
      リンクステーションホール青森
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-25461300
  • [Presentation] The molecular mechanism by which Aβ oligomers induce BACE1 up-regulation2015

    • Author(s)
      荒木 亘,儘田直美,保坂 愛,田之頭大輔,亀谷富由樹,石井一弘,玉岡 晃
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-25461300
  • [Presentation] The reversibility of neurotoxicity induced by amyloid-β oligomers2015

    • Author(s)
      Tanokashira D, Mamada N, Tamaoka A, Araki W
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PROJECT-25461300
  • [Presentation] アミロイドβタンパクによるBACE1の発現亢進2014

    • Author(s)
      荒木 亘,保坂 愛,儘田直美,田之頭大輔,玉岡 晃
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-12
    • Data Source
      KAKENHI-PROJECT-25461300
  • [Presentation] The subcellular localization of endogenous BACE1 and LRP1 in primary neurons.2014

    • Author(s)
      田之頭大輔, 儘田直美,玉岡 晃, Lakshmana Madepalli, 荒木 亘
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25
    • Data Source
      KAKENHI-PROJECT-25461300
  • [Presentation] アミロイドβ蛋白によるBACE1の発現亢進2013

    • Author(s)
      保坂 愛,嶺岸正治,玉岡 晃,荒木 亘
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京都、東京国際フォーラム
    • Data Source
      KAKENHI-PROJECT-25461300
  • [Presentation] スタチンのアミロイドβ蛋白産生抑制のメカニズムの検討2012

    • Author(s)
      保坂 愛,荒木 亘,織田彰子,富所康志,玉岡 晃
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば
    • Year and Date
      2012-10-27
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] Cleavage of amyloid precursor protein by BACE1 occurs mainly in non-raft membrane domains in neurons.2012

    • Author(s)
      Araki W, Motoki K, Oda A, Hosaka A, Tamaoka A, Kametani F
    • Organizer
      The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry / The 55th Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      神戸市、神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] βセクレターゼ(BACE1)のlow-density lipoprotein receptor?related protein 1 (LRP1)による抑制的制御2012

    • Author(s)
      嶺岸正治,Madepalli Lakshmana, 本木和美,保坂 愛,岡田尚巳,玉岡 晃,荒木 亘
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] スタチンのアミロイドβ蛋白産生低下作用に関する研究2012

    • Author(s)
      保坂 愛,荒木 亘,織田彰子,富所康志,玉岡 晃
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-23
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] Cleavage of amyloid precursor protein by BACE1 occurs mainly in non-raft membrane domains in neurons2012

    • Author(s)
      Araki W, Motoki K, Oda A, Hosaka A, Tamaoka A, Kametani F
    • Organizer
      The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry / The 55th Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      Kobe
    • Year and Date
      2012-10-01
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] βセクレターゼ(BACE1)のlow-density lipoprotein receptor-related protein 1 ( LRP1)による抑制的制御2012

    • Author(s)
      嶺岸正治,Madepalli Lakshmana, 本木和美,保坂 愛,岡田尚巳,玉岡 晃,荒木 亘
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡市、マリンメッセ福岡
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] βセクレターゼの脂質ラフト局在とβアミロイド産生2011

    • Author(s)
      荒木亘, 他4名
    • Organizer
      第30会日本認知症学会学術集会
    • Place of Presentation
      東京都、タワーホール船堀
    • Year and Date
      2011-11-11
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] βセクレターゼのパルミチル化と脂質ラフト移行・βアミロイド産生の関連2011

    • Author(s)
      荒木亘, 他3名
    • Organizer
      第52回日本神経学会総会
    • Place of Presentation
      愛知県、名古屋国際会議場
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] Reduction of beta-amyloid accumulation by reticulon 3 in transgenic mice2011

    • Author(s)
      Araki W, Oda A, Motoki M, Hattori K, Itoh M, Yuasa S, Konishi Y, Shin R-W, Tamaoka A, Ogino K
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease 2011
    • Place of Presentation
      Paris
    • Year and Date
      2011-07-18
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] βアミロイドタンパク産生におけるlow-density lipoprotein receptor-related protein (LRP-1)の役割2011

    • Author(s)
      本木和美,Madepali K Lakshmana, 玉岡 晃,岡田尚巳,荒木 亘
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] βセクレターゼのパルミチル化と脂質ラフト移行・βアミロイド産生の関連2011

    • Author(s)
      荒木 亘,本木和美,織田彰子,玉岡 晃
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] βセクレターゼの脂質ラフト局在とβアミロイド産生2011

    • Author(s)
      荒木 亘,本木和美,織田彰子,亀谷富由樹,玉岡 晃
    • Organizer
      第30会日本認知症学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-11
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] Reduction of beta-amyloid accumulation by reticulon 3 in transgenic mice2011

    • Author(s)
      Araki W, 他9名
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease 2011
    • Place of Presentation
      パリ市、Porte de Versailles
    • Year and Date
      2011-07-18
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] βセクレターゼのパルミチル化が脂質ラフト局在とβアミロイド産生に及ぼす影響2010

    • Author(s)
      本木和美,久米秀明, 織田彰子,玉岡 晃,亀谷富由樹,荒木 亘
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] アルツハイマー病モデルマウスにおけるβアミロイド蓄積のReticulon 3による抑制2010

    • Author(s)
      荒木亘, 他9名
    • Organizer
      第33回日本神経科学大会(Neuro2010.)
    • Place of Presentation
      神戸市神戸ポートアイラインド
    • Year and Date
      2010-09-03
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] アルツハイマー病モデルマウスにおけるβアミロイド蓄積のReticulon 3による抑制2010

    • Author(s)
      荒木 亘,織田彰子,本木和美,服部功太郎,伊藤雅之,湯浅茂樹,小西吉裕,辛 龍雲,玉岡 晃,荻野晃一
    • Organizer
      Neuro 2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] MEK阻害剤のβアミロイド産生低下作用2010

    • Author(s)
      荒木亘, 他2名
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京都千代田区東京国際フォーラム
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-22590951
  • [Presentation] IGF-Iはヒト神経系細胞においてβアミロイド産生をセクレターゼ非依存的なメカニズムにより促進する2009

    • Author(s)
      荒木 亘,久米秀明,亀谷富由樹
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-17
    • Data Source
      KAKENHI-PROJECT-19591025
  • [Presentation] IGF-Iはヒト神経系細胞においてβアミロイド産生をセクレターゼ非依存的なメカニズムにより促進する2009

    • Author(s)
      荒木亘, 他2名
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-03-17
    • Data Source
      KAKENHI-PROJECT-19591025
  • [Presentation] Molecular mechanisms by which reticulon 3 regulates β-secretase BACE12008

    • Author(s)
      Araki W, 他4名
    • Organizer
      The 11th International Conference on Alzheimer's Disease and Related Disorders
    • Place of Presentation
      アメリカ合衆国 シカゴ市
    • Year and Date
      2008-07-29
    • Data Source
      KAKENHI-PROJECT-19591025
  • [Presentation] Molecular mechanisms by which reticulon 3 regulates β-secretase BACE1.2008

    • Author(s)
      Araki W, Hideaki H, Murayama KS, Kametani F, Konishi Y
    • Organizer
      International Conference on Alzheimer's Disease
    • Place of Presentation
      Chicago
    • Year and Date
      2008-07-29
    • Data Source
      KAKENHI-PROJECT-19591025
  • [Presentation] Reticulonタンパクによるβセクレターゼ制御メカニズムの解析2008

    • Author(s)
      久米秀明, 村山紀代子, 荒木 亘
    • Organizer
      第27回日本認知症学会
    • Place of Presentation
      前橋
    • Year and Date
      2008-10-10
    • Data Source
      KAKENHI-PROJECT-19591025
  • [Presentation] 脂質ラフトのBACE1に対する酸化ストレスの影響2008

    • Author(s)
      織田彰子, 荒木 亘, 玉岡 晃
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-15
    • Data Source
      KAKENHI-PROJECT-19591025
  • [Presentation] Reticulon 3とBACE1の相互作用メカニズムの解析2007

    • Author(s)
      荒木 亘, 久米秀明, 村山紀代子, 亀谷富由樹
    • Organizer
      第50回日本神経化学会大会,第30回日本神経科学大会,第17回日本神経回路学会大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-11
    • Data Source
      KAKENHI-PROJECT-19591025
  • [Presentation] Expression of reticulon 3 in Alzheimer's disease brain2007

    • Author(s)
      荒木 亘, 他
    • Organizer
      日本日本認知症学会
    • Place of Presentation
      大阪市
    • Data Source
      KAKENHI-PROJECT-19591025
  • [Presentation] Reticulon 3とBACE1の相互作用メカニズムの解析2007

    • Author(s)
      荒木 亘, 他
    • Organizer
      日本神経化学会大会・日本神経科学大会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-09-11
    • Data Source
      KAKENHI-PROJECT-19591025
  • [Presentation] Expression of reticulon 3 in Alzheimer's disease brain.2007

    • Author(s)
      Araki W, Kume H, Murayama K, Kametani F, Konishi Y
    • Organizer
      第26回日本認知症学会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-19591025
  • [Presentation] アミロイドβタンパクのBACE1発現増強効果

    • Author(s)
      儘田直美,保坂 愛,田之頭大輔,石井一弘,玉岡 晃,荒木 亘
    • Organizer
      第33回日本認知症学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-30 – 2014-12-01
    • Data Source
      KAKENHI-PROJECT-25461300
  • 1.  KAMETANI Fuyuki (70186013)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 21 results
  • 2.  TAMAOKA Akira (50192183)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 36 results
  • 3.  KONISHI Yoshihiro (90170290)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 4.  LAKSHMANA Madepali
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 5.  TAKAHASHI Keikichi (40117148)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  ODA Akiko
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 15 results
  • 7.  OGINO Koichi
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  ARAKI Yumiko
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 32 results
  • 9.  YAMAMOTO FUMIKO
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 10.  YUASA Shigeki (70127596)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  SEKIGUCHI MASAYUKI (80260339)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TABIRA Takeshi (80112332)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 13.  TANAKA Shin (70134624)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  原 英夫 (00260381)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 15.  三條 伸夫 (00343153)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 16.  KUME Hideaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 17.  ITOH Masayuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  OKADA Takashi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 19.  SAITO Tamio
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  MOTOKI Kazumi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 12 results
  • 21.  MINEGISHI Seiji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 22.  HOSAKA Ai
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 23.  TANOKASHIRA DAISUKE
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 24.  MAMADA NAOMI
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 25.  TANIGUCHI KAORI
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 26.  ARAI TAKUYA
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  YANG JINWEI
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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