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KOYANAGI Satoru  小柳 悟

… Alternative Names

小柳 悟  コヤナギ サトル

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Researcher Number 60330932
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-4849-2377
Affiliation (Current) 2025: 九州大学, 薬学研究院, 教授
Affiliation (based on the past Project Information) *help 2016 – 2025: 九州大学, 薬学研究院, 教授
2015: 九州大学, 薬学研究科(研究院), 教授
2012 – 2015: 九州大学, 薬学研究科(研究院), 准教授
2010 – 2012: 九州大学, 薬学研究院, 准教授
2009 – 2012: 九州大学, 大学院・薬学研究院, 准教授 … More
2007: Kyushu University, 薬学研究院, 准教授
2005 – 2006: 九州大学, 薬学研究院, 助教授
2004: 福岡大学, 薬学部, 助手
2000 – 2002: Fukuoka Univ. Fac. Pharm. Sci. Research Associate, 薬学部, 助手 Less
Review Section/Research Field
Principal Investigator
Medium-sized Section 47:Pharmaceutical sciences and related fields / Pain science / Basic Section 47060:Clinical pharmacy-related / Pharmaceutical Sciences and related fields / Epidemiology and preventive medicine / Applied health science / 膠原病・アレルギー・感染症内科学 / Pathological medical chemistry / 応用薬理学・医療系薬学
Except Principal Investigator
Applied pharmacology … More / Physical pharmacy / Medium-sized Section 47:Pharmaceutical sciences and related fields / Biological pharmacy / Medical pharmacy Less
Keywords
Principal Investigator
時計遺伝子 / 概日リズム / 概日時計 / トランスポーター / 発がん / 生体リズム / がん性疼痛 / 神経障害痛 / 体内時計 / 時間薬物療法 … More / 個体内変動 / 個体間変動 / 薬物代謝酵素 / RNA編集 / 薬剤耐性 / がん幹細胞 / 鎮痛薬 / がん疼痛 / 鎮痛標的 / 短鎖ペプチド / 細胞膜タンパク / 足場タンパク質 / 副腎皮質ホルモン / 機能強化 / 細胞がん化 / 老化 / 活性化 / 抗がん剤感受性 / ATF4 / 加齢・老化 / 生活習慣病 / 神経障害性疼痛 / アストロサイト / 神経障害疼痛 / 医薬品開発 / アレルギー / 血小板由来増殖因子(PDGF) / がん / サーカディアンリズム / がん治療 … More
Except Principal Investigator
分子時計 / 薬学 / 光学分割 / アミノ酸 / 分析化学 / アポトーシス / 体内時計 / マクロファージ / 液性伝達時計 / 神経伝達時計 / 細胞伝達時計 / ケミカルバイオロジ― / 時間生物学 / 炎症 / ケミカルバイオロジー / 時間生物 / Anti-apoptotic action / Neuronal cell death / Angiogenesis / Proteinase inhibitor / Fibrinolytic factors / Ceramide / Apoptosis / Vascular endothelial cells / 虚血性心疾患 / 情報伝達因子 / 線溶制御因子 / 血管 / 神経細胞 / MAPキナーゼ系 / 線溶抑制因子 / 老化 / アストロサイト / 抗アポトーシス作用 / 神経細胞死 / 血管新生 / プロテアーゼインヒビター / 線溶系因子 / セラミド / 血管内皮細胞 / メタボロミクス / 幹細胞 / 恒常性 / 腎障害 / メタボローム / 創薬 / 分化 / がん Less
  • Research Projects

    (19 results)
  • Research Products

    (93 results)
  • Co-Researchers

    (19 People)
  •  脊髄に浸潤する免疫担当細胞に着目した神経障害性疼痛の性差の解明Principal Investigator

    • Principal Investigator
      小柳 悟
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kyushu University
  •  細胞伝達時計の機能解析と創薬育薬を指向した基礎的研究

    • Principal Investigator
      大戸 茂弘
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Kyushu University
  •  Exploration of analgesic drug based on the underlying mechanism of circadian variation in the cancer breakthrough painPrincipal Investigator

    • Principal Investigator
      小柳 悟
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Kyushu University
  •  Elucidation of the generation mechanism of cancer stem cells from circadian clock defective cells and development of strategy for overcoming of chemoresistancePrincipal Investigator

    • Principal Investigator
      Koyanagi Satoru
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Kyushu University
  •  Integration analysis between RNA editing and circadian clock system for elucidation of interindividual variation of drug pharmacokineticsPrincipal Investigator

    • Principal Investigator
      Koyanagi Satoru
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Kyushu University
  •  Study on molecular mechanism for scaffold protein-regulated circadian localization of transporters on plasma membrane byPrincipal Investigator

    • Principal Investigator
      Koyanagi Satoru
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Pharmaceutical Sciences and related fields
    • Research Institution
      Kyushu University
  •  Clarification of the mechanism underlying inflammation-based pathology from viewpoints of chrono-chemical biology

    • Principal Investigator
      OHDO Shigehiro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Applied pharmacology
    • Research Institution
      Kyushu University
  •  The underlying mechanism of glucocorticoid-regulated diurnal exacerbation of neuropathic pain hypersensitivity and its evaluation as a target of anti-allodynic drugPrincipal Investigator

    • Principal Investigator
      Koyanagi Satoru
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pain science
    • Research Institution
      Kyushu University
  •  Development of preventive strategy against oncogenesis by strengthening circadian clock functionPrincipal Investigator

    • Principal Investigator
      Koyanagi Satoru
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Epidemiology and preventive medicine
    • Research Institution
      Kyushu University
  •  Role of molecular clock on the homeostatic communication between each organ in chronic kidney disease

    • Principal Investigator
      Ohdo Shigehiro
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Applied pharmacology
    • Research Institution
      Kyushu University
  •  Early diagnosis of the defect in amino acid metabolism using chiral amino acid metabolomics

    • Principal Investigator
      Kenji Hamase
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Kyushu University
  •  Exploration of analgesic target for tumor-induced neuropathic pain based on the molecular mechanism of circadian rhythm in allodyniaPrincipal Investigator

    • Principal Investigator
      KOYANAGI Satoru
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pain science
    • Research Institution
      Kyushu University
  •  Development of preventive strategy for lifestyle-related diseases by activation of circadian clockPrincipal Investigator

    • Principal Investigator
      KOYANAGI SATORU
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Applied health science
    • Research Institution
      Kyushu University
  •  Development of an enantioselective amino acid metabolome analysismethod and its clinical applications

    • Principal Investigator
      HAMASE Kenji
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Kyushu University
  •  Discovery and development of antitumor drugs focused on the molecular clock of dedifferentiation and apoptosis during carcinogenesis

    • Principal Investigator
      OHDO Shigehiro
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Kyushu University
  •  アレルギー性疾患の発症に認められる日内変動の分子学的機構解明Principal Investigator

    • Principal Investigator
      小柳 悟
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Kyushu University
  •  PDGFシグナル伝達経路による腫瘍細胞増殖の日周リズム制御機構の解明Principal Investigator

    • Principal Investigator
      小柳 悟
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Fukuoka University
  •  血清中の細胞増殖因子を指標とした抗腫瘍薬の至適投薬タイミング設定Principal Investigator

    • Principal Investigator
      小柳 悟
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Fukuoka University
  •  Pathophysiological roles of the anti-fibrinolytic factor PAI-1 during aging or apoptotic process of blood vessel

    • Principal Investigator
      SOEDA Shinji
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Fukuoka University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

  • [Book] Biological Clocks2017

    • Author(s)
      Satoru Koyanagi, Naoki Kusunose, Naoya Matsunaga, Shigehiro Ohdo
    • Publisher
      北海道大学出版会(本間研一、本間さと 編)
    • ISBN
      9784832903722
    • Data Source
      KAKENHI-PROJECT-15H04765
  • [Book] Anti-angiogenic Functinal and Medicinal Foods2007

    • Author(s)
      Koyanagi, S., et. al.,
    • Total Pages
      715
    • Publisher
      Marcel Decker N.Y
    • Data Source
      KAKENHI-PROJECT-18790692
  • [Journal Article] Suppression of neuropathic pain in the circadian clock?deficient <i>Per2m/m</i> mice involves up-regulation of endocannabinoid system2024

    • Author(s)
      Yamakawa Wakaba、Yasukochi Sai、Tsurudome Yuya、Kusunose Naoki、Yamaguchi Yuta、Tsuruta Akito、Matsunaga Naoya、Ushijima Kentaro、Koyanagi Satoru、Ohdo Shigehiro
    • Journal Title

      PNAS Nexus

      Volume: 3 Issue: 1

    • DOI

      10.1093/pnasnexus/pgad482

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K18375
  • [Journal Article] Inhibition of Tumor-Derived C-C Motif Chemokine Ligand 2 Expression Attenuates Tactile Allodynia in NCTC 2472 Fibrosarcoma-Inoculated Mice2023

    • Author(s)
      Taniguchi Marie、Yasukochi Sai、Yamakawa Wakaba、Tsurudome Yuya、Tsuruta Akito、Horiguchi Michiko、Ushijima Kentaro、Yamashita Tomohiro、Shindo Naoya、Ojida Akio、Matsunaga Naoya、Koyanagi Satoru、Ohdo Shigehiro
    • Journal Title

      Molecular Pharmacology

      Volume: 104 Issue: 2 Pages: 73-79

    • DOI

      10.1124/molpharm.123.000690

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K18375, KAKENHI-PROJECT-23K23489
  • [Journal Article] Diurnal expression of PD-1 on tumor-associated macrophages underlies the dosing time-dependent anti-tumor effects of the PD-1/PD-L1 inhibitor BMS-1 in B16/BL6 melanoma-bearing mice.2022

    • Author(s)
      Tsuruta A, Shiiba Y, Matsunaga N, Fujimoto M, Yoshida Y, Koyanagi S, Ohdo S.
    • Journal Title

      Mol Cancer Res.

      Volume: MCR-21-0786-E Issue: 6 Pages: 972-982

    • DOI

      10.1158/1541-7786.mcr-21-0786

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K18249, KAKENHI-PROJECT-20K16306, KAKENHI-PROJECT-20K21484
  • [Journal Article] Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhibition of SGK-1 in the spinal cord2021

    • Author(s)
      Yasukochi S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S
    • Journal Title

      Biochemical Pharmacology

      Volume: 185 Pages: 114411-114411

    • DOI

      10.1016/j.bcp.2021.114411

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H04019
  • [Journal Article] Basis for diurnal exacerbation of neuropathic pain hypersensitivity and its application for drug development2021

    • Author(s)
      Koyanagi S, Kusunose N, Yasukochi S, Ohdo S
    • Journal Title

      J Biochem

      Volume: 143 Issue: 5 Pages: 1-4

    • DOI

      10.1093/jb/mvab143

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H04019
  • [Journal Article] RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein in human renal cells by regulating alternative splicing of the ABCB1 gene2021

    • Author(s)
      Omata Y, Yamauchi T, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 297 Pages: 100601-100601

    • DOI

      10.1016/j.jbc.2021.100601

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H04019
  • [Journal Article] Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity2020

    • Author(s)
      Kato M, Tsurudome Y, Kanemitsu T, Yasukochi S, Kanado Y, Ogino T, Matsunaga N, Koyanagi S, Ohdo S
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 13484-13484

    • DOI

      10.1038/s41598-020-70321-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H04019
  • [Journal Article] Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs.2019

    • Author(s)
      Kanado Y, Tsurudome Y, Omata Y, Yasukochi S, Kusunose N, Akamine T, Matsunaga N, Koyanagi S, Ohdo S.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 519 Issue: 3 Pages: 613-619

    • DOI

      10.1016/j.bbrc.2019.09.021

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-18H04019
  • [Journal Article] 足場タンパク質によるトランスポーター細胞膜局在の概日リズム制御2019

    • Author(s)
      鶴留 優也, 小柳 悟
    • Journal Title

      Farumashia

      Volume: 55 Issue: 4 Pages: 325-329

    • DOI

      10.14894/faruawpsj.55.4_325

    • NAID

      130007621944

    • ISSN
      0014-8601, 2189-7026
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19493
  • [Journal Article] Dosing Time-Dependent Changes in the Anti-tumor Effect of xCT Inhibitor Erastin in Human Breast Cancer Xenograft Mice2019

    • Author(s)
      Shiromizu S, Yamauchi T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 11 Pages: 1921-1925

    • DOI

      10.1248/bpb.b19-00546

    • NAID

      130007740594

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-11-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-18H04019
  • [Journal Article] Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene2018

    • Author(s)
      Katamune Chiharu、Koyanagi Satoru、Hashikawa Ken-ichi、Kusunose Naoki、Akamine Takahiro、Matsunaga Naoya、Ohdo Shigehiro
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Issue: 2 Pages: 547-558

    • DOI

      10.1074/jbc.ra118.004942

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17H06976
  • [Journal Article] Optimized dosing schedule based on circadian dynamics of mouse breast cancer stem cells improves the antitumor effects of aldehyde dehydrogenase inhibitor.2018

    • Author(s)
      Matsunaga N, Ogino T, Hara Y, Tanaka T, Koyanagi S, Ohdo S.
    • Journal Title

      Cancer Res.

      Volume: 78(13) Issue: 13 Pages: 3698-3708

    • DOI

      10.1158/0008-5472.can-17-4034

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262
  • [Journal Article] Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model2018

    • Author(s)
      Akamine Takahiro、Kusunose Naoki、Matsunaga Naoya、Koyanagi Satoru、Ohdo Shigehiro
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 503 Issue: 1 Pages: 181-187

    • DOI

      10.1016/j.bbrc.2018.05.209

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17H06976
  • [Journal Article] Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice.2018

    • Author(s)
      Shiromizu S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
    • Journal Title

      J Pharmacol Sci.

      Volume: 136 Issue: 4 Pages: 228-233

    • DOI

      10.1016/j.jphs.2018.01.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17K16972
  • [Journal Article] Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function.2018

    • Author(s)
      Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S.
    • Journal Title

      Scientific Reports

      Volume: 8(1) Issue: 1 Pages: 9072-9072

    • DOI

      10.1038/s41598-018-27280-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26220201, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17K19493, KAKENHI-PROJECT-18J11229
  • [Journal Article] Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system2018

    • Author(s)
      Kimura Hinako、Matsunaga Naoya、Kakimoto Keisuke、Watanabe Miyako、Tsuruta Akito、Kusunose Naoki、Shiromizu Shoya、Koyanagi Satoru、Ohdo Shigehiro
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 503 Issue: 2 Pages: 1063-1069

    • DOI

      10.1016/j.bbrc.2018.06.117

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262
  • [Journal Article] Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis2017

    • Author(s)
      Hashikawa KI, Katamune C, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S
    • Journal Title

      Scientific reports

      Volume: 7 Issue: 1 Pages: 9995-9995

    • DOI

      10.1038/s41598-017-10599-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636
  • [Journal Article] Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα.2017

    • Author(s)
      Kanemitsu T, Tsurudome Y, Kusunose N, Oda M, Matsunaga N, Koyanagi S, Ohdo S
    • Journal Title

      The Journal of biological chemistry

      Volume: 292 Issue: 52 Pages: 21397-21406

    • DOI

      10.1074/jbc.m117.791285

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262
  • [Journal Article] Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia.2016

    • Author(s)
      S. Koyanagi, N. Kusunose, M. Taniguchi, T. Akamine, Y. Kanado, Y. Ozono, T. Masuda, Y. Kohro, N. Matsunaga, M. Tsuda, M. Salter, K. Inoue, and S. Ohdo.
    • Journal Title

      Nat. Commun.

      Volume: 7 Issue: 1 Pages: 13102-13102

    • DOI

      10.1038/ncomms13102

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-25117013, KAKENHI-PROJECT-15H02522, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-15H04765, KAKENHI-PROJECT-16K18885
  • [Journal Article] Different roles of negative and positive components of the circadian clock in oncogene-induced neoplastic transformation.2016

    • Author(s)
      Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S, Ohdo S.
    • Journal Title

      J Biol Chem.

      Volume: in press

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25253038
  • [Journal Article] Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction.2016

    • Author(s)
      Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto T, Aramaki H, Irino Y, Koyanagi S, Ohdo S.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 291 Issue: 10 Pages: 4913-4927

    • DOI

      10.1074/jbc.m115.696930

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H06795, KAKENHI-PROJECT-25253038
  • [Journal Article] Different roles of negative and positive components of the circadian clock in oncogene-induced neoplastic transformation2016

    • Author(s)
      Chiharu Katamune, Satoru Koyanagi, Shoya Shiromizu, Naoya Matsunaga, Shigeki Shimba, Shigenobu Shibata, Shigehiro Ohdo
    • Journal Title

      The Journal of Biological Chemistry

      Volume: In press Issue: 20 Pages: 10541-10550

    • DOI

      10.1074/jbc.m115.706481

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26670317
  • [Journal Article] Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression.2016

    • Author(s)
      Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Tsuruta A, Tsurudome Y, Ogino T, Hara Y, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H, Aramaki H, Koyanagi S, Ohdo S
    • Journal Title

      The Journal of biological chemistry

      Volume: 291 Issue: 13 Pages: 7017-7028

    • DOI

      10.1074/jbc.m115.713412

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19167, KAKENHI-PROJECT-15H06795, KAKENHI-PROJECT-26860097, KAKENHI-PROJECT-25253038
  • [Journal Article] Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease.2016

    • Author(s)
      Matsunaga N, Ikeda E, Kakimoto K, Watanabe M, Shindo N, Tsuruta A, Ikeyama H, Hamamura K, Higashi K, Yamashita T, Kondo H, Yoshida Y, Matsuda M, Ogino T, Tokushige K, Itcho K, Furuichi Y, Nakao T, Yasuda K, Doi A, Amamoto T, Aramaki H, Tsuda M, Inoue K, Ojida A, Koyanagi S, Ohdo S
    • Journal Title

      EBioMedicine

      Volume: 13 Pages: 262-273

    • DOI

      10.1016/j.ebiom.2016.10.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-25117013, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-15H06795
  • [Journal Article] Modulation of peroxisome proliferator-activated receptor-α activity by bile acids causes circadian changes in the intestinal expression of Octn1/Slc22a4 in mice.2015

    • Author(s)
      Wada E, Koyanagi S, Kusunose N, Akamine T, Masui H, Hashimoto H, Matsunaga N, Ohdo S.
    • Journal Title

      Mol Pharmacol

      Volume: 87 Issue: 2 Pages: 314-322

    • DOI

      10.1124/mol.114.094979

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390149, KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079, KAKENHI-PROJECT-26670317, KAKENHI-PROJECT-26861456
  • [Journal Article] Bile acid-regulated peroxisome proliferator-activated receptor-α (PPARα) activity underlies circadian expression of intestinal peptide absorption transporter PepT1/Slc15a1.2014

    • Author(s)
      Okamura A, Koyanagi S, Dilxiat A, Kusunose N, Chen JJ, Matsunaga N, Shibata S, Ohdo S.
    • Journal Title

      J Biol Chem.

      Volume: 289(36) Issue: 36 Pages: 25296-25305

    • DOI

      10.1074/jbc.m114.577023

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079, KAKENHI-PROJECT-26220201, KAKENHI-PROJECT-26670317, KAKENHI-PROJECT-26861456
  • [Journal Article] Renal circadian clock regulates the dosing-time dependency of cisplatin-induced nephrotoxicity in mice.2014

    • Author(s)
      Oda M, Koyanagi S, Tsurudome Y, Kanemitsu T, Matsunaga N, Ohdo S.
    • Journal Title

      Mol Pharmacol

      Volume: 85 Issue: 5 Pages: 715-722

    • DOI

      10.1124/mol.113.089805

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390149, KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079, KAKENHI-PROJECT-26670317
  • [Journal Article] 24-Hour Rhythm of Aquaporin-3 Function in the Epidermis Is RegUlated by Molecular Clocks2014

    • Author(s)
      Naoya Matsunaga, Kazufumi Itcho, Kengo Hamamura, Eriko Ikeda, Hisako Ikeyama, Yoko Furuichi, Miyako Watanabe, Satoru Koyanagi, Shigehiro Ohdo
    • Journal Title

      Joumal of lnvestigative Dermatology

      Volume: (印刷中) Issue: 6 Pages: 1636-1644

    • DOI

      10.1038/jid.2014.13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J04175, KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079
  • [Journal Article] Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma2014

    • Author(s)
      Okazaki, H., Matsunaga, N., Fujioka, T., Okazaki, F., Akagawa, Y., Tsurudome, Y., Ono, M,. Kuwano, M., Koyanagi, S., and Ohdo, S.
    • Journal Title

      Cancer Res.

      Volume: 74 Issue: 2 Pages: 543-551

    • DOI

      10.1158/0008-5472.can-12-3241

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24650646, KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079
  • [Journal Article] Rhythmic control of the ARF-MDM2 pathway by ATF4 underlies circadian accumulation of p53 in malignant cells2013

    • Author(s)
      Horiguchi M, Koyanagi S, Hamdan AM, Kakimoto K, Matsunaga N, Yamashita C, Ohdo S
    • Journal Title

      Cancer Res

      Volume: 73(8) Pages: 2639-2649

    • Data Source
      KAKENHI-PROJECT-24650446
  • [Journal Article] Two-dimensional high-performance liquid chromatographic determination of day-night variation of D-alanine in mammals and factors controlling the circadian changes2013

    • Author(s)
      Sachise KARAKAWA, Yurika MIYOSHI, Ryuichi KONNO, Satoru KOYANAGI, Masashi MITA, Shigehiro OHDO, Kenji HAMASE
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: 405 Issue: 25 Pages: 8083-8091

    • DOI

      10.1007/s00216-013-7071-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293007
  • [Journal Article] The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S2013

    • Author(s)
      Hayashi Y, Koyanagi S, Kusunose N, Okada R, Wu Z, Tozaki-S aitoh H, Ukai K, Kohsaka S, Inoue K. Ohdo S. Nakanishi H.
    • Journal Title

      Scientific Reports

      Volume: vol.3 Issue: 1 Pages: 1-7

    • DOI

      10.1038/srep02744

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J05694, KAKENHI-PROJECT-23229008, KAKENHI-PROJECT-24390149, KAKENHI-PROJECT-24791979, KAKENHI-PLANNED-25117013
  • [Journal Article] Rhythmic control of the ARF-MDM2 pathway by ATF4 underlies circadian accumulation of p53 in malignant cells2013

    • Author(s)
      Horiguchi M, Koyanagi S, Hamdan AM, Kakimoto K, Matsunaga N, Yamashita C, Ohdo S
    • Journal Title

      Cancer Research

      Volume: 73 Pages: 2639-2649

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24650446
  • [Journal Article] Rhythmic control of the ARF-MDM2 pathway by ATF4 underlies cireadian accumulation2013

    • Author(s)
      Horiguchi M, Koyanagi S, et al
    • Journal Title

      Cancer Research

      Volume: 73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390149
  • [Journal Article] Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors2012

    • Author(s)
      Horiguchi M, Koyanagi S, Okamoto A, Suzuki SO, Matsunaga N, Ohdo S.
    • Journal Title

      Cancer Res

      Volume: 72(2) Pages: 395-401

    • Data Source
      KAKENHI-PROJECT-21390047
  • [Journal Article] Influence of CLOCK on cytotoxicity induced by diethylnitrosamine in mouse primary hepatocytes2011

    • Author(s)
      Matsunaga N, Kohno Y, Kakimoto K, Hayashi A, Koyanagi S, Ohdo S.
    • Journal Title

      Toxicology

      Volume: 280(3) Pages: 144-151

    • Data Source
      KAKENHI-PROJECT-21390047
  • [Journal Article] Molecular basis of chronopharmaceutics2011

    • Author(s)
      Ohdo S, Koyanagi S, Matsunaga N, Hamdan A.
    • Journal Title

      J Pharm Sci

      Volume: 100(9) Pages: 3560-3576

    • Data Source
      KAKENHI-PROJECT-21390047
  • [Journal Article] Glucocorticoid-dependent expression of O(6)-methylguanine-DNA methyltransferase gene modulates dacarbazine-induced hepatotoxicity in mice2010

    • Author(s)
      Horiguchi M, Kim J, Matsunaga N, Kaji H, Egawa T, Makino K, Koyanagi S, Ohdo S.
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 333(3) Pages: 782-787

    • Data Source
      KAKENHI-PROJECT-21390047
  • [Journal Article] Chronopharmacological strategies : Intraand inter-individual variability of molecular clock2010

    • Author(s)
      Ohdo S, Koyanagi S, Matsunaga N.
    • Journal Title

      Adv Drug Deliv Rev

      Volume: 62(9-10) Pages: 885-897

    • Data Source
      KAKENHI-PROJECT-21390047
  • [Journal Article] Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice2010

    • Author(s)
      Okazaki F, Matsunaga N, Okazaki H, Utoguchi N, Suzuki R, Maruyama K, Koyanagi S, Ohdo S.
    • Journal Title

      Cancer Res

      Volume: 70(15) Pages: 6238-6246

    • Data Source
      KAKENHI-PROJECT-21390047
  • [Journal Article] Hypoxia-response plasmid vector producing bcl-2 shRNA enhances the apoptotic cell death of mouse rectum carcinoma2010

    • Author(s)
      Fujioka T, Matsunaga N, Okazaki H, Koyanagi S, Ohdo S.
    • Journal Title

      J Pharmacol Sci

      Volume: 113(4) Pages: 353-361

    • NAID

      10027746067

    • Data Source
      KAKENHI-PROJECT-21390047
  • [Journal Article] Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene2009

    • Author(s)
      Kim J, Matsunaga N, Koyanagi S, Ohdo S.
    • Journal Title

      Biochem Pharmacol

      Volume: 78(8) Pages: 1075-1082

    • Data Source
      KAKENHI-PROJECT-21390047
  • [Journal Article] Modulator effects of 5-fluorouracil on the rhythmic expression of circadian clock genes: A possible mechanism of chemotherapy-induced circadian rhythm disturbances2008

    • Author(s)
      Koyanagi, S., et. al.,
    • Journal Title

      Biochem. Pharmacol. 75

      Pages: 1616-1622

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790692
  • [Journal Article] Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2 cells2007

    • Author(s)
      Koyanagi, S., et. al.,
    • Journal Title

      Pharmacogenet. Genomics 17

      Pages: 1047-1056

    • NAID

      130005024316

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790692
  • [Journal Article] Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver2006

    • Author(s)
      Koyanagi S., Suyama H., Kuramoto Y., Matsunaga N.et al.
    • Journal Title

      Endocrinology 147巻

      Pages: 5037-5040

    • Data Source
      KAKENHI-PROJECT-18790692
  • [Journal Article] Chronic treatment with prednisolone represses the circadian oscillation of clock gene expression in mouse peripheral tissues2006

    • Author(s)
      Koyanagi S., et al.
    • Journal Title

      Molecular Endocrinology 20

      Pages: 573-583

    • Data Source
      KAKENHI-PROJECT-16790194
  • [Journal Article] Circadian regulation of mouse topoisomerase I gene expression by glucocorticoid hormones2006

    • Author(s)
      Kuramoto Y., Hata K., Koyanagi S., Ohdo S., Shimeno H.et al.
    • Journal Title

      Biochemical Pharmacology 71巻

      Pages: 1155-1161

    • Data Source
      KAKENHI-PROJECT-18790692
  • [Journal Article] Synthesis and biological evaluation of 9-(5',5'-difluoro-5'-phosphono-pentyl)guanine derivatives for PNP-inhibitors2006

    • Author(s)
      Hikishima S., Isobe M., Koyanagi S., et al.
    • Journal Title

      Bioorganic & Medicinal Chemistry 14

      Pages: 1660-1670

    • Data Source
      KAKENHI-PROJECT-16790194
  • [Journal Article] Chronopharmacological study of antidepressants in forced swimming test in mice2005

    • Author(s)
      Ushijima K., Sakaguchi H., Sato Y., To H., Koyanagi S., et al.
    • Journal Title

      Journal of Pharmacology and Experimental. Therapeutics 315

      Pages: 764-770

    • Data Source
      KAKENHI-PROJECT-16790194
  • [Journal Article] Cell cycle dependent pharmacology of methotrexate in HL-60.2005

    • Author(s)
      Yamauchi A., Ichimiya T., Inoue K., Taguchi Y., Matsunaga N., Koyanagi S.
    • Journal Title

      Journal of Pharmacological Science 99

      Pages: 335-341

    • NAID

      10025731653

    • Data Source
      KAKENHI-PROJECT-16790194
  • [Journal Article] Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder2005

    • Author(s)
      Takimoto M., Hamada A., Tomoda A., Ohdo S., Ohmura T., Sakato H., Kawatani J., Jodoi T., Nakagawa H., Terazono H., Koyanagi S., et al.
    • Journal Title

      Am.J.Physiol.Regul.Integr.Comp.Physiol 289

      Pages: 1273-1279

    • Data Source
      KAKENHI-PROJECT-16790194
  • [Journal Article] Glucocorticoid hormone regulates the circadian coordination of μ-opioid receptor expression in mouse brainstem2005

    • Author(s)
      Yoshida M., Koyanagi S., et al.
    • Journal Title

      Journal of Pharmacology and Experimental. Therapeutics 315

      Pages: 1119-1124

    • Data Source
      KAKENHI-PROJECT-16790194
  • [Journal Article] 24-hr oscillation of mouse methionine aminopeptidase2, a regulator of tumor progression, is regulated by clock gene proteins2004

    • Author(s)
      H.Nakagawa, S.Koyanagi et al.
    • Journal Title

      Cancer Research 64

      Pages: 8328-8333

    • Data Source
      KAKENHI-PROJECT-16790194
  • [Presentation] SGLT2阻害薬エンパグリフロジンの投薬時刻依存的な糖尿病性末梢神経障害発症の抑制効果に及ぼす摂食時刻の影響解析2024

    • Author(s)
      佐藤 愛、岩中 菜穂、安河内 冴、山内 智暁、鶴田 朗人、小柳 悟、大戸 茂弘
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PROJECT-22K18375
  • [Presentation] 時計遺伝子の機能不全マウスを用いた神経障害性疼痛の発症抑制メカニズムの解析2024

    • Author(s)
      山川 稚葉、安河内 冴、鶴留 優也、牛島 健太郎、鶴田 朗人、松永 直哉、小柳 悟、大戸 茂弘
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PROJECT-22K18375
  • [Presentation] 神経障害性疼痛の概日変動メカニズム2023

    • Author(s)
      小柳 悟
    • Organizer
      第45回日本疼痛学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K18375
  • [Presentation] RNA編集酵素ADAR1によるヒト腎細胞でのP糖タンパク質発現の概日リズム制御機構2021

    • Author(s)
      小俣 裕司、山内 智暁、鶴田 朗人、松永 直哉、小柳 悟、大戸 茂弘
    • Organizer
      日本薬学会 第141年会
    • Data Source
      KAKENHI-PROJECT-18H04019
  • [Presentation] ヒト腎近位尿細管上皮細胞におけるP糖タンパク質発現の概日リズム制御機構の解析2020

    • Author(s)
      小俣裕司、鶴田朗人、松永直哉、小柳悟、大戸茂弘
    • Organizer
      日本薬剤学会第35年会
    • Data Source
      KAKENHI-PROJECT-18H04019
  • [Presentation] ヒト腎近位尿細管上皮細胞におけるP糖タンパク質発現の概日リズム制御機構の解析2020

    • Author(s)
      小俣 裕司、山内 智暁、鶴田 朗人、松永 直哉、小柳 悟、大戸 茂弘
    • Organizer
      第41回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-18H04019
  • [Presentation] 転写後過程における薬物代謝酵素CYP3A4活性の概日リズム制御の解析2019

    • Author(s)
      田尻楓、小俣裕司、松永直哉、小柳悟、大戸茂弘
    • Organizer
      第36回日本薬学会九州支部大会
    • Data Source
      KAKENHI-PROJECT-18H04019
  • [Presentation] 神経障害性疼痛の概日リズム制御機構を基盤とした病態解明と創薬への応用2018

    • Author(s)
      楠瀬 直喜、小柳 悟、松永 直哉、大戸 茂弘
    • Organizer
      日本薬学会138回年会(シンポジウム講演)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04765
  • [Presentation] Chronopharmacology based on circadian clock-regulated xenobiotic transporters2018

    • Author(s)
      Koyanagi Satoru
    • Organizer
      2018 International meeting on 22nd MOD and 33rd Annual Meeting of JSSX
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19493
  • [Presentation] 副腎皮質ホルモンによる脊髄細胞外への ATP放出と慢性痛の概日変動2017

    • Author(s)
      小柳 悟
    • Organizer
      第44回日本毒性学会学術年会(シンポジウム講演)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04765
  • [Presentation] Chrono-omics analysis for exploring diagnostic and therapeutic target for neuropathic pain.2017

    • Author(s)
      Satoru Koyanagi
    • Organizer
      日本薬物動態学会 第32回年会(シンポジウム講演)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04765
  • [Presentation] 概日リズム研究の創薬・医療への応用2017

    • Author(s)
      小柳 悟
    • Organizer
      第11回次世代を担う若手医療薬科学シンポジウム(教育講演)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04765
  • [Presentation] 神経障害性疼痛の概日リズム制御機構と治療・創薬研究への応用2017

    • Author(s)
      楠瀬 直喜、小柳 悟、松永 直哉、大戸 茂弘
    • Organizer
      医療薬学フォーラム2017(シンポジウム講演)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04765
  • [Presentation] Circadian clock regulation of intra-individual variations in drug disposition Translational Research of Chrono-pharmacokinetics2017

    • Author(s)
      Satoru Koyanagi
    • Organizer
      International Conference of Precision Medicine (Taipei)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19493
  • [Presentation] Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of pain hypersensitivity after peripheral nerve injury2016

    • Author(s)
      Satoru Koyanagi
    • Organizer
      Sapporo Symposium on Biological Rhythm in 2016
    • Place of Presentation
      北海道大学
    • Year and Date
      2016-11-09
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04765
  • [Presentation] Molecular basis for circadian regulation of the intensity of cancer-derived pain in tumor-bearing mice2015

    • Author(s)
      谷口真理恵、小柳悟、楠瀬直喜、赤嶺孝祐、松永直哉、大戸茂弘
    • Organizer
      第9回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      千葉(千葉大学)
    • Year and Date
      2015-11-07
    • Data Source
      KAKENHI-PROJECT-15H04765
  • [Presentation] Circadian oscillation in the intestinal expression of Octn1/Slc22a4 underlies the dosing time-dependent changes in the absorption of pregabalin and its analgesic effects on diabetic neuropathy2015

    • Author(s)
      赤嶺孝祐、和田恵里香、楠瀬直喜、橋本華、谷口真理恵、松永直哉、小柳悟、大戸茂弘
    • Organizer
      第9回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      千葉(千葉大学)
    • Year and Date
      2015-11-07
    • Data Source
      KAKENHI-PROJECT-15H04765
  • [Presentation] Chronopharmacological study of pregabalin for diabetic peripheral neuropathic pain2015

    • Author(s)
      赤嶺孝祐、和田恵里香、楠瀬直喜、橋本華、谷口真理恵、松永直哉、小柳悟、大戸茂弘
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京(東京大学)
    • Year and Date
      2015-11-21
    • Data Source
      KAKENHI-PROJECT-15H04765
  • [Presentation] 神経障害性疼痛の概日リズム形成メカニズムと鎮痛標的分子の探索2014

    • Author(s)
      小柳悟、楠瀬直喜、松永直哉、大戸茂弘
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市(熊本大学)
    • Data Source
      KAKENHI-PROJECT-24390149
  • [Presentation] Molecular basis for circadian regulation of neuropathic pain in mice2013

    • Author(s)
      Kusunose N, Koyanagi S, et al
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-03-21
    • Data Source
      KAKENHI-PROJECT-24390149
  • [Presentation] 概日時計因子ATF4によるトランスポーター発現リズムと抗がん剤感受性の制御2013

    • Author(s)
      小柳 悟、松永直哉、大戸茂弘
    • Organizer
      第35回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      東京都
    • Invited
    • Data Source
      KAKENHI-PROJECT-24650446
  • [Presentation] 神経障害性疼痛の概日リズム制御に関わるグルココルチコイド標的遺伝子の探索2013

    • Author(s)
      楠瀬直喜、小柳悟、松永直哉、大戸茂弘
    • Organizer
      第20回日本時間生物学会学術大会
    • Place of Presentation
      大阪市(近畿大学)
    • Data Source
      KAKENHI-PROJECT-24390149
  • [Presentation] がん細胞の薬剤感受性の概日リズム制御メカニズムと投薬のタイミング.2013

    • Author(s)
      大戸茂弘、小柳悟、松永直哉
    • Organizer
      第86回 日本生化学会
    • Place of Presentation
      横浜
    • Invited
    • Data Source
      KAKENHI-PROJECT-25253038
  • [Presentation] Chronopharmacological aspects of transporters2013

    • Author(s)
      大戸茂弘、小柳悟、松永直哉
    • Organizer
      日本薬物動態学会 第28回年会
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-25253038
  • [Presentation] 時間薬理による副作用低減.シンポジウム「副作用低減のための新しい薬理学的アプローチ」(オーガナイザー:植田真一郎、大石了三)2011

    • Author(s)
      大戸茂弘、小柳悟、松永直哉
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21390047
  • [Presentation] 分子時計を基盤にした時間治療.シンポジウム「生命現象を担う生体分子に着目した創薬と臨床応用」(オーガナイザー:荒牧弘範、前仲勝実)2011

    • Author(s)
      大戸茂弘、小柳悟、松永直哉
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-21390047
  • [Presentation] 創薬・育薬を指向した時間薬剤学的研究2010

    • Author(s)
      大戸茂弘、小柳悟、松永直哉
    • Organizer
      第47回薬剤学懇談会研究討論会「新技術・新素材が切り拓く薬剤開発」岐阜県飛騨高山
    • Place of Presentation
      高山グリーンホテル、天領閣
    • Year and Date
      2010-06-24
    • Data Source
      KAKENHI-PROJECT-21390047
  • [Presentation] 時間薬理学とは.シンポジウム「時間薬理学と時間栄養学による新しい治療戦略の開拓」(オーガナイザー:柴田重信、大戸茂弘)2010

    • Author(s)
      大戸茂弘、小柳悟、松永直哉
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-21390047
  • [Presentation] 癌の時間治療と今後の展望.シンポジウム「体内時計を利用した創薬から治療戦略まで」(オーガナイザー:柴田重信、守屋孝洋)2010

    • Author(s)
      大戸茂弘、小柳悟、松永直哉
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-21390047
  • [Presentation] 体内時計の分子機構を基盤にした薬物投与設計.シンポジウム1「薬物療法を支える基礎研究と臨床研究の糸口、進め方と成果の活用」(オーガナイザー:家入一郎、大戸茂弘)2010

    • Author(s)
      小柳悟、松永直哉、大戸茂弘
    • Organizer
      医療薬学フォーラム2010第18回クリニカルファーマシーシンポジウム
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-21390047
  • [Presentation] Molecular clock mechanisms of drug metabolism.2009

    • Author(s)
      Ohdo S, Matsunaga N, Koyanagi S.
    • Organizer
      Symposium"Functional genomics"16th International Conference on Cytochrome P450
    • Place of Presentation
      Japan(Okinawa)
    • Data Source
      KAKENHI-PROJECT-21390047
  • [Presentation] 抗がん剤の時間薬理.シンポジウム4「PK/PD解析から見た抗がん剤の効果・副作用」(オーガナイザー:鈴木洋史、桂敏也)2009

    • Author(s)
      大戸茂弘、松永直哉、小柳悟
    • Organizer
      医療薬学フォーラム2009第17回クリニカルファーマシーシンポジウム
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21390047
  • [Presentation] Molecular basis for circadian sensitivity of tumor cells to chemotherapeutic agents

    • Author(s)
      Koyanagi S, Matsunaga N, Ohdo S
    • Organizer
      Spring Annual Convention of Pharmaceutical Society of Korea / Korea-Japan Joint Symposium
    • Place of Presentation
      Seoul (Korea)
    • Year and Date
      2014-04-17 – 2014-04-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670317
  • [Presentation] 概日時計因子ATF4によるトランスポーター発現リズムと抗がん剤感受性の制御

    • Author(s)
      小柳悟, 松永直哉, 大戸茂弘
    • Organizer
      第35回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      東京大学
    • Data Source
      KAKENHI-PROJECT-24650446
  • [Presentation] Exploration of analgesic target for neurophatic pain based on the molecular mechanism of circadian rhythm in allodynia

    • Author(s)
      小柳悟、楠瀬直喜、大戸茂弘
    • Organizer
      The 87th Annual Meeting of the Japanese Biochemical Society
    • Place of Presentation
      京都市(京都国際会議場)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-24390149
  • [Presentation] 転写因子ATF4によるトランスポーター発現リズムと抗がん剤感受性の制御

    • Author(s)
      小柳 悟、松永直哉、大戸茂弘
    • Organizer
      第8回トランスポーター研究会
    • Place of Presentation
      熊本市
    • Invited
    • Data Source
      KAKENHI-PROJECT-24650446
  • [Presentation] Distinct role of Per2 and Bmal1 in oncogenic malignant transformation

    • Author(s)
      Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S, Ohdo S
    • Organizer
      International Symposium by Japanese Society of Chronobiology in 2014
    • Place of Presentation
      Fukuoka
    • Year and Date
      2014-11-07 – 2014-11-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670317
  • [Presentation] 転写因子ATF4によるトランスポーター発現リズムと抗がん剤感受性の制御

    • Author(s)
      小柳悟, 松永直哉, 大戸茂弘
    • Organizer
      第8回トランスポーター研究会
    • Place of Presentation
      熊本大学
    • Data Source
      KAKENHI-PROJECT-24650446
  • 1.  NAOYA Matsunaga (10432915)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 31 results
  • 2.  OHDO Shigehiro (00223884)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 24 results
  • 3.  HAMASE Kenji (10284522)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  UEDA Tadashi (90184928)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  AISO Sadakazu (60138013)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  TSUDA Makoto (40373394)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 7.  ENDO Fumio (00176801)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  SOEDA Shinji (20078695)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  SHIMENO Hiroshi (00078693)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KIHARA Taro (20289549)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  TSURUDOME YUYA
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  MASUDA Takahiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  楠瀬 直喜
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 14.  井上 和秀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 15.  濱村 賢吾
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  岡崎 裕之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  田原 優
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  柴田 重信
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  桑野 信彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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