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Yagyu Hiroaki  野牛 宏晃

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YAGYU Hiroaki  野牛 宏晃

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Researcher Number 60348018
Other IDs
Affiliation (Current) 2025: 筑波大学, 医学医療系, 教授
Affiliation (based on the past Project Information) *help 2014: 自治医科大学, 医学部, 研究員
2012 – 2014: 自治医科大学, 医学部, 非常勤講師
2012: 自治医科大学, 医学部, 准教授
2012: 自治医科大学, 医学部, 研究員
2010 – 2011: 自治医科大学, 医学部, 講師
2004 – 2008: 自治医科大学, 医学部, 講師
2003: 自治医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Metabolomics
Except Principal Investigator
Metabolomics
Keywords
Principal Investigator
リポ蛋白リパーゼ / 脂質代謝 / 肝臓 / 動脈硬化 / マクロファージ / PPAR-α / 心筋障害 / 脂肪毒性 / 脂肪酸
Except Principal Investigator
コレステロール … More / マクロファージ / liver dysfunction / knockout / mouse / albumin / liver / squalene synthase / HMG-CoA reductase / cholesterol / 細胞増殖 / ミエリン / 血管平滑筋細胞 / スクアレン合成酵素 / HMG-CoA還元酵素 / 肝障害 / ノックアウト / マウス / アルブミン / 肝臓 / スクワレン合成酵素 / IMG-CoA還元酵素 / 粥状動脈硬化症 / 泡沫化 / コレステロールエステル / ACAT / アポトーシス / NCEH1 / ERストレス / 脂質代謝異常 / オキシステロール / 細胞死 / 小胞体ストレス / リパーゼ / トリグリセライド / 膵β細胞 / 脂肪毒性 / トリグリセライド水解酵素 / ホルモン感受性リパーゼ / ブドウ糖 / リバーゼ / トリングリセライド / インスリン Less
  • Research Projects

    (7 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (10 People)
  •  The roles of hepatic lipoprotein lipase and its regulating factors on the hepatic lipotoxicityPrincipal Investigator

    • Principal Investigator
      YAGYU Hiroaki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  Genetic analysis of molecular mechanisms of foam cell formation in atherosclerosis

    • Principal Investigator
      OSUGA JUN-ICHI
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  Study on the endoplasmic stress induced by oxsterol ester and its implication to diseases

    • Principal Investigator
      ISHIBASHI Shun
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  The role of macrophage lipoprotein lipase on the development of atherosclerosisPrincipal Investigator

    • Principal Investigator
      YAGYU Hiroaki
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  膵β細胞脂肪毒性解除による新規2型糖尿病治療法の開発

    • Principal Investigator
      ISHIBASHI Shun
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  Elucidation of novel functions of cholesterol and its metabolites using genetic manipulation in mice

    • Principal Investigator
      ISHIBASHI Shun
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University
  •  心臓特異的リポ蛋白リパーゼ過剰発現マウスの脂肪毒性による心筋障害のメカニズム解明Principal Investigator

    • Principal Investigator
      野牛 宏晃
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Metabolomics
    • Research Institution
      Jichi Medical University

All 2013 2012 2011 2009 2007 2006 Other

All Journal Article Presentation Book Other

  • [Book] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis

    • Author(s)
      Sekiya, M., Osuga, JI., Yahagi, N., Okazaki, H., Tamura, Y., Igarashi, M., Takase, S., Harada, K., Okazaki, S., Iizuka, Y., Ohashi, K., Yagyu, H., Okazaki, M., Gotoda, T., Nagai, R., Kadowaki, T., Shimano, H., Yamada, N., Ishibashi, S
    • Publisher
      J Lipid Res in press
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Journal Article] Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity2013

    • Author(s)
      Takahashi M, Yagyu H, Tazoe F, Nagashima S, Ohshiro T, Okada K, Osuga J, Goldberg IJ, Ishibashi S.
    • Journal Title

      J Lipid Res

      Volume: 54(4) Issue: 4 Pages: 1124-34

    • DOI

      10.1194/jlr.m035568

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390187, KAKENHI-PROJECT-23591339, KAKENHI-PROJECT-25293213
  • [Journal Article] Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, decreases cholesteryl ester transfer protein in type 2 diabetes mellitus.2012

    • Author(s)
      Yagyu H, Nagashima S, Takahashi M, Miyamoto M, Okada K, Osuga J, Ishibashi S.
    • Journal Title

      Endocr J.

      Volume: 59 Pages: 1077-1084

    • NAID

      10031146718

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591339
  • [Journal Article] Current smoking status may be associated with overt albuminuria in female patients with type 1 diabetes mellitus: a cross-sectional study.2012

    • Author(s)
      Okada K, Osuga J, Kotani K, Yagyu H, Miyamoto M, Nagasaka S, Ishibashi S.
    • Journal Title

      Tob Induc Dis.

      Volume: 10 Issue: 1 Pages: 12-12

    • DOI

      10.1186/1617-9625-10-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591339
  • [Journal Article] Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.2012

    • Author(s)
      Nagashima S, Yagyu H, Ohashi K, Tazoe F, Takahashi M, Ohshiro T, Bayasgalan T, Okada K, Sekiya M, Osuga J, Ishibashi S.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 32(8) Issue: 8 Pages: 1824-31

    • DOI

      10.1161/atvbaha.111.240754

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390187, KAKENHI-PROJECT-23591339
  • [Journal Article] an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia.2011

    • Author(s)
      Ohshiro T, Matsuda D, Sakai K, Degirolamo C, Yagyu H, Rudel LL, Omura S, Ishibashi S, Tomoda H. Pyripyropene A
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 31(5) Issue: 5 Pages: 1108-15

    • DOI

      10.1161/atvbaha.111.223552

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390187
  • [Journal Article] Molecular analysis of a novel LCAT mutation (Gly179→Arg) found in a patient with complete LCAT deficiency2011

    • Author(s)
      Wang XL, Osuga J, Tazoe F, Okada K, Nagashima S, Takahashi M, Ohshiro T, Bayasgalan T, Yagyu H, Okada K, Ishibashi S
    • Journal Title

      J Atheroscler Thromb

      Volume: 18(8)(Epub 2011 May 20) Pages: 713-9

    • NAID

      130004444539

    • URL

      https://www.jstage.jst.go.jp/article/jat/18/8/18_8003/_article

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591339
  • [Journal Article] Depot-specific expression of lipolytic genes in human adipose tissues-association among CES1 expression, triglyceride lipase activity and adiposity.2011

    • Author(s)
      Nagashima S, Yagyu H, Takahashi N, Kurashina T, Takahashi M, Tsuchita T, Tazoe F, Wang XL, Bayasgalan T, Sato N, Okada K, Nagasaka S, Gotoh T, Kojima M, Hyodo M, Horie H, Hosoya Y, Okada M, Yasuda Y, Fujiwara H, Ohwada M, Iwamoto S, Suzuki M, Nagai H, Ish
    • Journal Title

      J Atheroscler Thromb.

      Volume: 18(3) Pages: 190-9

    • Data Source
      KAKENHI-PROJECT-22390187
  • [Journal Article] Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver2006

    • Author(s)
      Okazaki, H., Tazoe, F., Okazaki, S., Isoo, N., Tsukamoto, K., Sekiya, M., Yahagi, N., Iizuka, Y., Ohashi, K., Kitamine, T., Tozawa, R., Inaba, T., Yagyu, H., Okazaki, M., Shimano, H., Shibata, N., Arai, H., Nagai, R.Z., Kadowaki, T., Osuga, J., Ishibashi, S
    • Journal Title

      J Lipid Res 47

      Pages: 1950-1958

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Journal Article] Cholesterol reduction and atherosclerosis of inhibition by bezafibrate in low density lipoprotein receptor knockout mice

    • Author(s)
      Inaba, T. Yagyu, H. Itabashi, N. Tazoe, F. Fujita, N. Nagashima, S. Okada, K. Okazaki, M. Furukawa, Y. Ishibashi, S
    • Journal Title

      Hypertens Res (in press)

    • NAID

      10021935912

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Presentation] マクロファージ特異的リポタンパクリパーゼ欠損マウスにおける動脈硬化進展の短期及び長期的検討2009

    • Author(s)
      高橋学、野牛宏晃、田副文子、永島秀一、岡田健太、宮本倫聡、大城太一、江藤一弘、石橋俊
    • Organizer
      第52回糖尿病学会年次集会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-18590998
  • [Presentation] 肝臓特異的スクアレン合成酵素欠損マウスにおける血清・肝臓の脂質代謝の検討2007

    • Author(s)
      永島 秀一、野牛 宏晃、田副 文子、石橋 俊, 他
    • Organizer
      第39回日本動脈硬化学会総会・学術集会,
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-13
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Presentation] Lipid metabolism in liver-sepecific squalene synthase knockout mice.2007

    • Author(s)
      Nagashima, S., Yagyu, H., Tazoe, F., Ishibashi, S., et. al.
    • Organizer
      The 39th Annual Scientific Meeting of the Japan Atherosclerosis Society
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Presentation] ssential role of non-sterol pathway in the proliferation of vascular smooth muscle cells : A comparative study on the disruption of 3-hydroxy-3-Methylglutaryl coenzyme A reductase or squalene synthase2006

    • Author(s)
      Tazoe, F., Yagyu, H., Itabashi, N., Ohashi, K., Tozawa, R., Inaba, T., Nagashima, S., Kato, K., Khadbaatar, Z., Osuga, J., Ishibashi, S
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • [Presentation] Cell proliferation of vascular smooth muscle cells with defective cholesterol biosynthesis2006

    • Author(s)
      Tazoe, F., Yagyu, H., Nagashima, S., Ishibashi, S., et. al.
    • Organizer
      The 38th Annual Scientific Meeting of the Japan Atherosclerosis Society
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390266
  • []

  • []

  • 1.  ISHIBASHI Shun (90212919)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 14 results
  • 2.  NAGASHIMA Shuichi (30406136)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 3.  OOSUGA Junniti (10334400)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 4.  TAZOE Fumiko (20406127)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 5.  TAKAHASHI Manabu (70406122)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  板橋 直樹 (00316522)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  加藤 秀樹 (20406094)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  OKAZAKI Hiroaki (80610211)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  WANG Xiao li (10458325)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  安藤 明彦 (60249315)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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