YAGYU Hiroaki 野牛宏晃

Researcher Number	60348018
Other IDs
Affiliation (based on the past Project Information) *help	2014: 自治医科大学, 医学部, 研究員 2012 – 2014: 自治医科大学, 医学部, 非常勤講師 2012: 自治医科大学, 医学部, 准教授 2012: 自治医科大学, 医学部, 研究員 2010 – 2011: 自治医科大学, 医学部, 講師 2004 – 2008: 自治医科大学, 医学部, 講師 2003: 自治医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Metabolomics Except Principal Investigator Metabolomics
Keywords	Principal Investigator リポ蛋白リパーゼ / 脂質代謝 / 肝臓 / 動脈硬化 / マクロファージ / PPAR-α / 心筋障害 / 脂肪毒性 / 脂肪酸 Except Principal Investigator コレステロール … More / マクロファージ / liver dysfunction / knockout / mouse / albumin / liver / squalene synthase / HMG-CoA reductase / cholesterol / 細胞増殖 / ミエリン / 血管平滑筋細胞 / スクアレン合成酵素 / HMG-CoA還元酵素 / 肝障害 / ノックアウト / マウス / アルブミン / 肝臓 / スクワレン合成酵素 / IMG-CoA還元酵素 / 粥状動脈硬化症 / 泡沫化 / コレステロールエステル / ACAT / アポトーシス / NCEH1 / ERストレス / 脂質代謝異常 / オキシステロール / 細胞死 / 小胞体ストレス / リパーゼ / トリグリセライド / 膵β細胞 / 脂肪毒性 / トリグリセライド水解酵素 / ホルモン感受性リパーゼ / ブドウ糖 / リバーゼ / トリングリセライド / インスリン Less

The roles of hepatic lipoprotein lipase and its regulating factors on the hepatic lipotoxicityPrincipal Investigator
- Principal Investigator
  
  YAGYU Hiroaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Genetic analysis of molecular mechanisms of foam cell formation in atherosclerosis
- Principal Investigator
  
  OSUGA JUN-ICHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Study on the endoplasmic stress induced by oxsterol ester and its implication to diseases
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
The role of macrophage lipoprotein lipase on the development of atherosclerosisPrincipal Investigator
- Principal Investigator
  
  YAGYU Hiroaki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
膵β細胞脂肪毒性解除による新規2型糖尿病治療法の開発
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
Elucidation of novel functions of cholesterol and its metabolites using genetic manipulation in mice
- Principal Investigator
  
  ISHIBASHI Shun
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University
心臓特異的リポ蛋白リパーゼ過剰発現マウスの脂肪毒性による心筋障害のメカニズム解明Principal Investigator
- Principal Investigator
  
  野牛宏晃
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jichi Medical University

All 2013 2012 2011 2010 2009 2007 2006 Other

All Journal Article Presentation Book

[Book] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis
- Author(s)
  Sekiya, M., Osuga, JI., Yahagi, N., Okazaki, H., Tamura, Y., Igarashi, M., Takase, S., Harada, K., Okazaki, S., Iizuka, Y., Ohashi, K., Yagyu, H., Okazaki, M., Gotoda, T., Nagai, R., Kadowaki, T., Shimano, H., Yamada, N., Ishibashi, S
- Publisher
  J Lipid Res in press
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity2013
- Author(s)
  Takahashi M, Yagyu H, Tazoe F, Nagashima S, Ohshiro T, Okada K, Osuga J, Goldberg IJ, Ishibashi S.
- Journal Title
  
  J Lipid Res
  
  Volume: 54(4) Issue: 4 Pages: 1124-34
- DOI
  10.1194/jlr.m035568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390187, KAKENHI-PROJECT-23591339, KAKENHI-PROJECT-25293213
[Journal Article] Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, decreases cholesteryl ester transfer protein in type 2 diabetes mellitus.2012
- Author(s)
  Yagyu H, Nagashima S, Takahashi M, Miyamoto M, Okada K, Osuga J, Ishibashi S.
- Journal Title
  
  Endocr J.
  
  Volume: 59 Pages: 1077-1084
- NAID
  10031146718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Current smoking status may be associated with overt albuminuria in female patients with type 1 diabetes mellitus: a cross-sectional study.2012
- Author(s)
  Okada K, Osuga J, Kotani K, Yagyu H, Miyamoto M, Nagasaka S, Ishibashi S.
- Journal Title
  
  Tob Induc Dis.
  
  Volume: 10 Issue: 1 Pages: 12-12
- DOI
  10.1186/1617-9625-10-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.2012
- Author(s)
  Nagashima S, Yagyu H, Ohashi K, Tazoe F, Takahashi M, Ohshiro T, Bayasgalan T, Okada K, Sekiya M, Osuga J, Ishibashi S.
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 32(8) Issue: 8 Pages: 1824-31
- DOI
  10.1161/atvbaha.111.240754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390187, KAKENHI-PROJECT-23591339
[Journal Article] an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia.2011
- Author(s)
  Ohshiro T, Matsuda D, Sakai K, Degirolamo C, Yagyu H, Rudel LL, Omura S, Ishibashi S, Tomoda H. Pyripyropene A
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 31(5) Issue: 5 Pages: 1108-15
- DOI
  10.1161/atvbaha.111.223552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390187
[Journal Article] Molecular analysis of a novel LCAT mutation (Gly179→Arg) found in a patient with complete LCAT deficiency2011
- Author(s)
  Wang XL, Osuga J, Tazoe F, Okada K, Nagashima S, Takahashi M, Ohshiro T, Bayasgalan T, Yagyu H, Okada K, Ishibashi S
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 18(8)(Epub 2011 May 20) Pages: 713-9
- NAID
  130004444539
- URL
  https://www.jstage.jst.go.jp/article/jat/18/8/18_8003/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591339
[Journal Article] Depot-specific expression of lipolytic genes in human adipose tissues-association among CES1 expression, triglyceride lipase activity and adiposity.2011
- Author(s)
  Nagashima S, Yagyu H, Takahashi N, Kurashina T, Takahashi M, Tsuchita T, Tazoe F, Wang XL, Bayasgalan T, Sato N, Okada K, Nagasaka S, Gotoh T, Kojima M, Hyodo M, Horie H, Hosoya Y, Okada M, Yasuda Y, Fujiwara H, Ohwada M, Iwamoto S, Suzuki M, Nagai H, Ish
- Journal Title
  
  J Atheroscler Thromb.
  
  Volume: 18(3) Pages: 190-9
- Data Source
  KAKENHI-PROJECT-22390187
[Journal Article] The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages2010
- Author(s)
  Igarashi M, Kadowaki T
- Journal Title
  
  Circ. Res
  
  Volume: 107 Issue: 11 Pages: 1387-1395
- DOI
  10.1161/circresaha.110.226613
- Data Source
  KAKENHI-PROJECT-20229008, KAKENHI-PROJECT-22390187
[Journal Article] Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement2010
- Author(s)
  Ohta K, Sekiya M, Uozaki H, Igarashi M, Takase S, Kumagai M, Takanashi M, Takeuchi Y, Izumida Y, Kubota M, Nishi M, Okazaki H, Iizuka Y, Yahagi N, Yagyu H, Fukayama M, Kadowaki T, Ohashi K, Ishibashi S, Osuga JI
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 404 Issue: 1 Pages: 254-60
- DOI
  10.1016/j.bbrc.2010.11.103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591123, KAKENHI-PROJECT-22390187, KAKENHI-PLANNED-23116006, KAKENHI-PROJECT-23591339
[Journal Article] Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver2006
- Author(s)
  Okazaki, H., Tazoe, F., Okazaki, S., Isoo, N., Tsukamoto, K., Sekiya, M., Yahagi, N., Iizuka, Y., Ohashi, K., Kitamine, T., Tozawa, R., Inaba, T., Yagyu, H., Okazaki, M., Shimano, H., Shibata, N., Arai, H., Nagai, R.Z., Kadowaki, T., Osuga, J., Ishibashi, S
- Journal Title
  
  J Lipid Res 47
  
  Pages: 1950-1958
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Journal Article] Cholesterol reduction and atherosclerosis of inhibition by bezafibrate in low density lipoprotein receptor knockout mice
- Author(s)
  Inaba, T. Yagyu, H. Itabashi, N. Tazoe, F. Fujita, N. Nagashima, S. Okada, K. Okazaki, M. Furukawa, Y. Ishibashi, S
- Journal Title
  
  Hypertens Res (in press)
- NAID
  10021935912
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] マクロファージ特異的リポタンパクリパーゼ欠損マウスにおける動脈硬化進展の短期及び長期的検討2009
- Author(s)
  高橋学、野牛宏晃、田副文子、永島秀一、岡田健太、宮本倫聡、大城太一、江藤一弘、石橋俊
- Organizer
  第52回糖尿病学会年次集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-18590998
[Presentation] 肝臓特異的スクアレン合成酵素欠損マウスにおける血清・肝臓の脂質代謝の検討2007
- Author(s)
  永島秀一、野牛宏晃、田副文子、石橋俊, 他
- Organizer
  第39回日本動脈硬化学会総会・学術集会,
- Place of Presentation
  大阪
- Year and Date
  2007-07-13
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] Lipid metabolism in liver-sepecific squalene synthase knockout mice.2007
- Author(s)
  Nagashima, S., Yagyu, H., Tazoe, F., Ishibashi, S., et. al.
- Organizer
  The 39th Annual Scientific Meeting of the Japan Atherosclerosis Society
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] ssential role of non-sterol pathway in the proliferation of vascular smooth muscle cells : A comparative study on the disruption of 3-hydroxy-3-Methylglutaryl coenzyme A reductase or squalene synthase2006
- Author(s)
  Tazoe, F., Yagyu, H., Itabashi, N., Ohashi, K., Tozawa, R., Inaba, T., Nagashima, S., Kato, K., Khadbaatar, Z., Osuga, J., Ishibashi, S
- Organizer
  American Heart Association Scientific Sessions 2006
- Place of Presentation
  Chicago
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266
[Presentation] Cell proliferation of vascular smooth muscle cells with defective cholesterol biosynthesis2006
- Author(s)
  Tazoe, F., Yagyu, H., Nagashima, S., Ishibashi, S., et. al.
- Organizer
  The 38th Annual Scientific Meeting of the Japan Atherosclerosis Society
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390266

1. ISHIBASHI Shun (90212919)

# of Collaborated Projects: 6 results

# of Collaborated Products: 14 results
2. NAGASHIMA Shuichi (30406136)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. OOSUGA Junniti (10334400)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. TAZOE Fumiko (20406127)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. TAKAHASHI Manabu (70406122)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 板橋直樹 (00316522)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 加藤秀樹 (20406094)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. OKAZAKI Hiroaki (80610211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. WANG Xiao li (10458325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 安藤明彦 (60249315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 門脇孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 矢作直也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAGYU Hiroaki 野牛 宏晃

Research Projects

Research Products

Co-Researchers

The roles of hepatic lipoprotein lipase and its regulating factors on the hepatic lipotoxicityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic analysis of molecular mechanisms of foam cell formation in atherosclerosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the endoplasmic stress induced by oxsterol ester and its implication to diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of macrophage lipoprotein lipase on the development of atherosclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

膵β細胞脂肪毒性解除による新規2型糖尿病治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of novel functions of cholesterol and its metabolites using genetic manipulation in mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

心臓特異的リポ蛋白リパーゼ過剰発現マウスの脂肪毒性による心筋障害のメカニズム解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis

Author(s)

Publisher

Description

Data Source

[Journal Article] Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, decreases cholesteryl ester transfer protein in type 2 diabetes mellitus.2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Current smoking status may be associated with overt albuminuria in female patients with type 1 diabetes mellitus: a cross-sectional study.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular analysis of a novel LCAT mutation (Gly179→Arg) found in a patient with complete LCAT deficiency2011

Author(s)

Journal Title

NAID

YAGYU Hiroaki 野牛宏晃