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Uzawa Hirotaka  鵜沢 浩隆

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UZAWA Hirotaka  鵜沢 浩隆

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Researcher Number 60356566
Other IDs
External Links
Affiliation (Current) 2025: 国立研究開発法人産業技術総合研究所, 材料・化学領域, 主任研究員
Affiliation (based on the past Project Information) *help 2023: 国立研究開発法人産業技術総合研究所, 材料・化学領域, 主任研究員
2018 – 2022: 国立研究開発法人産業技術総合研究所, 材料・化学領域, 上級主任研究員
2015: 国立研究開発法人産業技術総合研究所, ナノ材料研究部門, 上級主任研究員
2015: 国立研究開発法人産業技術総合研究所, ナノシステム研究部門, 上級主任研究員
2012 – 2014: 独立行政法人産業技術総合研究所, ナノシステム研究部門, 上級主任研究員 … More
2005 – 2006: 独立行政法人産業技術総合研究所, バイオニクス研究センター, 研究チーム長
2005 – 2006: 産業技術総合研究所, バイオニクス研究センター, チーム長
2004: 産業技術総合研究所, バイオニクス, チーム長 Less
Review Section/Research Field
Principal Investigator
Basic Section 38040:Bioorganic chemistry-related / Applied molecular and cellular biology
Except Principal Investigator
Basic Section 27040:Biofunction and bioprocess engineering-related / Polymer chemistry / Social systems engineering/Safety system
Keywords
Principal Investigator
ライブラリー / 認識 / 細菌性毒素 / リガンド / 固定化 / ケモエンザイム合成 / 相互作用 / 毒素 / 相互作用解析 / 検知チップ … More / ガングリオシド / 合成 / 糖脂質 / sensing / chip / Shiga toxins / carbohydrate / sugar / 生体機能利用 / ベロ毒素 / センシング / 有害蛋白質 / チップ / 糖鎖 … More
Except Principal Investigator
BSE / 糖鎖 / 生物毒素 / 表面解析 / 生体模倣膜 / 検知チップ / heparan sulfate / glycomics / oligosaccharide / prion / sulfated sugars / module synthesis / glycosaminoglycans / 糖鎖ライブラリー / モジュール化 / 光反応性プローブ / アルツハイマー / 糖鎖モジュール化法 / ライブラリー合成 / 糖鎖医薬 / モジュール合成 / グライコミクス / ヘパラン硫酸 / プリオン / 硫酸化糖 / グリコサミノグリカン / 吸着 / 機器分析 / 分子認識 / テロ対策 Less
  • Research Projects

    (5 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (11 People)
  •  スフィンゴ糖脂質を積層した生体模倣膜の表面解析法の開発と生物毒素感染機構の解明

    • Principal Investigator
      Ding Wuxiao
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 27040:Biofunction and bioprocess engineering-related
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Molecular structure-based study on the affinity of Clostridium producing toxins to human cell surface glycolipidsPrincipal Investigator

    • Principal Investigator
      UZAWA Hirotaka
    • Project Period (FY)
      2018 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 38040:Bioorganic chemistry-related
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Creation of molecular recognition tool against biological toxins and development of effective decontamination techniques

    • Principal Investigator
      Seto Yasuo
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Social systems engineering/Safety system
    • Research Institution
      National Research Institute of Police Science
  •  Development of carbohydrate chipsfor high-sensitive analysis targeting biohazard proteinsPrincipal Investigator

    • Principal Investigator
      UZAWA Hirotaka
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied molecular and cellular biology
    • Research Institution
      National Institute of Advanced Industrial Science and Technology (AIST)
  •  Module Assembly and Evaluation of Artificial Glycosaminoglycans

    • Principal Investigator
      NISHIDA Yoshihiro
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Polymer chemistry
    • Research Institution
      Chiba University
      Nagoya University

All 2024 2023 2021 2020 2019 2013 2012 2007 2006 2005 2004

All Journal Article Presentation Book Patent

  • [Book] バイオセンサ・ケミカルセンサ事典 「糖鎖」2007

    • Author(s)
      鵜沢浩隆
    • Publisher
      株式会社テクノシステム(近日刊行)
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380202
  • [Journal Article] Novel Glycolipid Chips with a Double Layer of Au Nanoparticles for Biological Toxin Detection2023

    • Author(s)
      Uzawa Hirotaka、Nagatsuka Takehiro、Seto Yasuo、Nishida Yoshihiro、Saito Masato、Tamiya Eiichi
    • Journal Title

      ACS Omega

      Volume: 8 Issue: 15 Pages: 13754-13762

    • DOI

      10.1021/acsomega.2c07976

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K05469
  • [Journal Article] Assembly of Glycochips with Mammalian GSLs Mimetics toward the On-site Detection of Biological Toxins2021

    • Author(s)
      Uzawa Hirotaka、Kondo Satoshi、Nagatsuka Takehiro、Miyaguchi Hajime、Seto Yasuo、Oshita Aguri、Dohi Hirofumi、Nishida Yoshihiro、Saito Masato、Tamiya Eiichi
    • Journal Title

      ACS Omega

      Volume: 6 Issue: 48 Pages: 32597-32606

    • DOI

      10.1021/acsomega.1c04154

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K05469
  • [Journal Article] Silicon nitride sugar chips for detection of Ricinus communis proteins and Escherichia coli O157 Shiga toxins2019

    • Author(s)
      Daiki Tanaka, Hirotaka Uzawa, Takehiro Nagatsuka, Yuki Oba, Atsunori Hiratsuka, Ken-ichi Tayama, Toshio Yoshida, Yasuo Seto, Hirofumi Dohi, Yoshihiro Nishida
    • Journal Title

      Analytical Biochemistry

      Volume: 580 Pages: 42-48

    • DOI

      10.1016/j.ab.2019.06.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K05469
  • [Journal Article] Glycotechnology for decontamination of biological agents : A model study using ricin and biotin-tagged synthetic glycopolymers2012

    • Author(s)
      T. Nagatsuka, H. Uzawa, K. Sato, I. Ohsawa。Y. Seto and Y. Nishida
    • Journal Title

      ACS Applied Materials & Interfaces

      Volume: 4 Issue: 2 Pages: 832-837

    • DOI

      10.1021/am201493q

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24310125
  • [Journal Article] Effective chemoenzymatic synthesis of p-aminophenyl glycosides of sialyl N-acetyllactosaminide and anlyasis of their interactions with lectins2007

    • Author(s)
      X.Zeng, Sun H, J Liu, X iang, B Zhou, J.Uzawa
    • Journal Title

      Carbohydrate Research (印刷中)

    • Data Source
      KAKENHI-PROJECT-17380202
  • [Journal Article] Synthesis of p -nitrophenyl sulfated disaccharides with β-D-(6-sulfo)-GlcNAc units using β- N -acetylhexosaminidase from Aspergillus oryzae in a transglycosylation reaction2007

    • Author(s)
      Xiaoxiong Zeng, Yi Sun, Hong Ye, Jun Liu, Hirotaka Uzawa
    • Journal Title

      Biotechnology Letters 29

      Pages: 1105-1110

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380202
  • [Journal Article] Substrate specificity of N-acetylhexosaminidase from Aspergillus oryzae to artificial glycosyl acceptors having various substituents at the reducing ends2007

    • Author(s)
      Makoto Ogata, Xiaoxiong Zeng, Taichi Usui, Hirotaka Uzawa
    • Journal Title

      Carbohydrate Research 342

      Pages: 23-30

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380202
  • [Journal Article] Synthesis of p-nitrophenyl sulfated disaccharides with B-D-(6-sulfo)-G1cNAc units using 6- N-acetylhexosaminidase from Aspergillus oryzae in a transglycosylation reaction2007

    • Author(s)
      Xiaoxiong Zeng, Yi Sun, Hong Ye, Jun Liu, Hirotaka Uzawa
    • Journal Title

      Biotechnology Letters 29

      Pages: 1105-1110

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17380202
  • [Journal Article] Effective chemoenzymatic synthesis of p-aminophenyl glycosides of sialyl N-acetyllactosaminide and analysis of their interactions with lectins2007

    • Author(s)
      Xiaoxiong Zeng, Yi Sun, Hong Ye, Jun Liu, Xiaoli Xiang, Bei Zhou, Hirotaka Uzawa
    • Journal Title

      Carbohydrate Research 342

      Pages: 1244-1248

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380202
  • [Journal Article] 糖鎖で毒素を捕らえるテロ対策の新技術2006

    • Author(s)
      鵜沢浩隆
    • Journal Title

      化学 61

      Pages: 18-22

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380202
  • [Journal Article] A bovine glucuronidase for assembly of β-D-glucuronyl-(1-3)-6-O-sulfo-β-D-gluco- and galacto-pyranosyl linkages2006

    • Author(s)
      Hirotaka Uzawa, Takehiro Nagatsuka, Hideo Hiramatsu, Yoshihiro Nishida
    • Journal Title

      Chemical Communications (印刷中)

    • Data Source
      KAKENHI-PROJECT-17380202
  • [Journal Article] A bovine glucuronidase for assembly of β-D-glucuronyl-(1-3)-6-O-sulfo-β-D-gluco- and galactopyranosyl linkages2006

    • Author(s)
      H.Uzawa, T.Nagatsuka, H.Hiramatsu, Y.Nishida
    • Journal Title

      Chemical Communication (印刷中)

    • Data Source
      KAKENHI-PROJECT-16350063
  • [Journal Article] A bovine glucuronidase for assembly of beta-D-glucuronyl-(1-3)-6-O-sulfo-beta-D-gluco- and galactopyranosyl linkages2006

    • Author(s)
      H.Uzawa, T.Nagatsuka, H.Hiramatsu, Y.Nishida
    • Journal Title

      Chemical Communications.

      Pages: 1381-1383

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16350063
  • [Journal Article] A bovine glucuronidase for assembly of D-D-glucuronyl-(1-3)-6-O-sulfo-D-D-gluco- and galacto-pyranosyl linkages2006

    • Author(s)
      Hirotaka Uzawa, Takehiro Nagatsuka, Hideo Hiramatsu, Yoshihiro Nishida
    • Journal Title

      Chemical Communications

      Pages: 1381-1383

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380202
  • [Journal Article] A bovine glucuronidase for assembly of beta-D-glucuronyl-(1-3)-6-0-sulfo-beta-D-gluco- and galactopyranosyl linkages2006

    • Author(s)
      H.Uzawa, T.Natatsuka, H.Hiramatsu, Y.Nishida
    • Journal Title

      Chemical Communication

      Pages: 1381-1383

    • Data Source
      KAKENHI-PROJECT-16350063
  • [Journal Article] A bovine glucuronidase for assembly of beta-D-glucuronyl-(1-3)-6-O-sulfo-beta-D-gluco- and galactopyranosyl linkages2006

    • Author(s)
      H.Uzawa, T.Nagatsuka, H.Hiramatsu, Y.Nishida
    • Journal Title

      Chemical Communication

      Pages: 1381-1383

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16350063
  • [Journal Article] A bovine glucuronidase for assembly of β-D-glucuronyl-(1-3)-6-0-sulfo-β-D-gluco-and galacto-pyranosyl linkages2006

    • Author(s)
      Hirotaka Uzawa, Takehiro Nagatsuka, Hideo Hiramatsu, Yoshihiro Nishida
    • Journal Title

      Chemical Communications

      Pages: 1381-1383

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17380202
  • [Journal Article] Inhibition of PrP^<Sc> formation by synthetic O-sulfated glycopyranosides and their polymers2006

    • Author(s)
      S.Yamaguchi, Y.Nishida, M.Kambara, C.-L.Kim, N.Ishiguro, T.Nagatsuka, H.Uzawa, M.Horiuchi
    • Journal Title

      Biochem. Biophys. Res. Commun. 349

      Pages: 485-491

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16350063
  • [Journal Article] Convenient enzymatic synthesis of a p-nitrophenyl oligosaccharide series of sialyl N-acetyllactosamine, sialyl Lex and relevant compounds2005

    • Author(s)
      Xiaoxiong Zeng, Hirotaka Uzawa
    • Journal Title

      Carbohydrate Research 340

      Pages: 2469-2475

    • Data Source
      KAKENHI-PROJECT-17380202
  • [Journal Article] Efficient Enzymatic Synthesis of 4-methylumbelliferyl N-acetyllactosaminide and 4-methylumbelliferyl sialyl N-acetyllactosaminides Employing B-D-galactosidase and Sialyltransferases2005

    • Author(s)
      Xiaoxiong Zeng, Yi Sun, Hirotaka Uzawa
    • Journal Title

      Biotechnology Letters 27

      Pages: 1461-1465

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17380202
  • [Journal Article] Efficient Enzymatic Synthesis of 4-methylumbelliferyl N-acetyllactosaminide and 4-methylumbelliferyl sialyl N-acetyllactosaminides Employing β-D-galactosidase and Sialyltransferases2005

    • Author(s)
      Xiaoxiong Zeng, Yi Sun, Hirotaka Uzawa
    • Journal Title

      Biotechnology Letters 27

      Pages: 1461-1465

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380202
  • [Journal Article] Synthesis of polyanionic glycopolymers for the facile assembly of glycosyl arrays2005

    • Author(s)
      Hirotaka Uzawa, Hiroki Ito, Masayuki Izumi, Hideo Tokuhisa, Kazuhiro Taguchi, Norihiko Minoura
    • Journal Title

      Tetrahedron 61

      Pages: 5895-5905

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380202
  • [Journal Article] Convenient enzymatic synthesis of a p-nitrophenyl oligosaccharide series of sialyl N-acetyllactosamine, sialyl Le^x and relevant compounds2005

    • Author(s)
      Xiaoxiong Zeng, Hirotaka Uzawa
    • Journal Title

      Carbohydrate Research 340

      Pages: 2469-2475

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380202
  • [Journal Article] Design of N-acetyl-6-sulfo-beta-D-glucosaminide based inhibitors of influenza virus sialidase2004

    • Author(s)
      K.Sasaki, Y.Nishida, M.Kambara, H.Uzawa, T.Takahashi, T.Suzuki, Y.Suzuki, K.Kobayashi
    • Journal Title

      Bioorg. Med. Chem. 12

      Pages: 1367-1375

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16350063
  • [Journal Article] Sulfatase-catalyzed assembly of regioselectively O-sulfated p-nitrophenyl alpha-D-gluco- and alpha-D-mannonyranosides2004

    • Author(s)
      H.Uzawa, Y.Nishida, K.Sasaki, T.Nagatsuka, H.Hiramatsu, K.Kobayashi
    • Journal Title

      Carbohydr. Res. 339

      Pages: 1597-1602

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16350063
  • [Journal Article] Sulfatase-catalyzed assembly of regioselectively O-sulfated p-nitrophenyl α-D-gluco- and α-D-mannopyranosides2004

    • Author(s)
      Uzawa, H., Nishida, Y.他4名
    • Journal Title

      Carbohydrate. Research 339

      Pages: 1597-1602

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16350063
  • [Journal Article] Sulfatase-catalyzed assembly of regioselectively O-sulfated p-nitrophenyl α-D-gluco- and α-D-mannopyranosides2004

    • Author(s)
      Uzawa, H., Nishida, Y.他 4名
    • Journal Title

      Carbohydrate.Research 339

      Pages: 1597-1602

    • Data Source
      KAKENHI-PROJECT-16350063
  • [Patent] 非特異的吸着抑制効果の高い糖鎖リガンド、および該糖鎖リガンドを固定化した毒素検知チップ2024

    • Inventor(s)
      鵜沢 浩隆
    • Industrial Property Rights Holder
      国立研究開発法人産業技術総合研究所
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2024
    • Data Source
      KAKENHI-PROJECT-18K05469
  • [Patent] 非特異的吸着抑制効果の高い糖鎖リガンド、および該糖鎖リガンドを固定化した毒素検知チップ2020

    • Inventor(s)
      鵜沢浩隆
    • Industrial Property Rights Holder
      国立研究開発法人 産業技術総合研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-071741
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-18K05469
  • [Patent] 硫酸基含有糖化合物、それを用いるサーズウイルスまたはインフルエンザウイルスの検出2005

    • Inventor(s)
      鵜沢浩隆, 曽暁雄
    • Industrial Property Rights Holder
      産業技術総合研究所理事長
    • Industrial Property Number
      2005-173184
    • Filing Date
      2005-06-14
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380202
  • [Patent] シアル酸含有3糖化合物、それを用いるサーズウイルスまたはサーズスパイク蛋白質の検出2005

    • Inventor(s)
      鵜沢浩隆, 曽暁雄
    • Industrial Property Rights Holder
      産業技術総合研究所理事長
    • Industrial Property Number
      2005-173183
    • Filing Date
      2005-06-14
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17380202
  • [Presentation] Silicon Nitride Chips Modified with Gb3 Trisaccharide for Rapid Detection of Verotoxins2019

    • Author(s)
      Hirotaka Uzawa, Atsunori Hiratsuka, Yasuo Seto, Ken-ichi Tayama, Toshio Yoshida, Yoshihiro Nishida
    • Organizer
      10th International Conference on Molecular Electronics and Bioelectronics (M&BE10)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K05469
  • [Presentation] ケモエンザイム法による糖脂質ライブラリーの構築2019

    • Author(s)
      鵜沢浩隆、平塚淳典
    • Organizer
      第18回 産総研・産技連 LS-BT合同研究発表会
    • Data Source
      KAKENHI-PROJECT-18K05469
  • [Presentation] DEVELOPMENT OF ON-SITE DECONTAMINATION TECHNOLOGIES – PHOTOCATALYTIC DEGRADATION FOR CHEMICAL WARFARE AGENTS AND MOLECULAR RECOGNITION ADSORPTION FOR BIOLOGICAL TOXINS2013

    • Author(s)
      Yasuo Seto, Takeshi Ohmori, Mieko Kanamori-Kataoka, Kouichiro Tsuge, Isaac Ohsawa, Shintaro Kishi, Yuji Urushibata, Keita Sato, Asuka Komano, Hirotaka Uzawa, Takehiro Nagatsuka, Koji Takeuchi, Nobuaki Negishi, Tsutomu Hirakawa and Masahiro Furuno
    • Organizer
      11th International symposium on Protection against Chemical and Biological Warfare agents
    • Place of Presentation
      Stockholm
    • Data Source
      KAKENHI-PROJECT-24310125
  • 1.  Seto Yasuo (10154668)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 2.  OHSAWA Isaku (30370886)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  MIYAGUCHI Hajime (10370884)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  NISHIDA Yoshihiro (80183896)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 5.  MIURA Yoshiko (00335069)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  HORIUCHI Motohiro (30219216)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  IZUMI Masayuki (80332641)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  柘 浩一郎 (90356204)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  小林 一清 (10023483)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 10.  平塚 淳典 (70392652)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 11.  Ding Wuxiao (90598757)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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