• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

KUWATA NOBUYO  鍬田 伸好 (東 伸好)

… Alternative Names

東伸好

Higashi-Kuwata Nobuyo  鍬田 伸好

KUWATA Nobuyo  鍬田 伸好

鍬田 伸好(東伸好)  クワタ ノブヨ

HIGASHI Nobuyo  東 伸好

Less
Researcher Number 60361218
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-9404-3532
External Links
Affiliation (Current) 2025: 国立健康危機管理研究機構, 国立国際医療研究所, 室長
Affiliation (based on the past Project Information) *help 2023 – 2024: 国立研究開発法人国立国際医療研究センター, その他部局等, 研究所 難治性ウイルス感染症研究部 室長
2020: 国立研究開発法人国立国際医療研究センター, その他部局等, 研究所 難治性ウイルス感染症研究部 主任研究員
2019: 国立研究開発法人国立国際医療研究センター, 研究所 難治性ウイルス感染症研究部, 主任研究員
2018: 国立研究開発法人国立国際医療研究センター, その他部局等, 主任研究員
2012: 熊本大学, エイズ学研究センター, 特任助教
2005: 秋田大, 医学部, 助手
2003 – 2004: 秋田大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 54030:Infectious disease medicine-related / Infectious disease medicine / General anatomy (including Histology/Embryology)
Except Principal Investigator
Biological Sciences / General anatomy (including Histology/Embryology) / Environmental physiology (including Physical medicine and Nutritional physiology) / General anatomy (including Histology/Embryology) / Pediatric surgery
Keywords
Principal Investigator
新規核酸系抗HBV化合物 / HBV / B型慢性肝炎 / cccDNA / ヒト肝キメラマウス / 抗ウイルス薬開発 / ヒトB型肝炎ウイルス / HBV感染症 / SASP / テロメア長 … More / p16 / 老化関連β-ガラクトシダーゼ / 抗HBV核酸アナログ / 細胞老化 / p21 / 老化関連βガラクトシダーゼ / 抗HBV核酸アナログと細胞老化細胞老化 / 抗HBV核酸アナログと細胞老化 / HBV感染と細胞老化 / HBV感染 / Raltegravir / 抗HIV薬 / in vivo imaging / AIDS / HIVmCherry / humanized マウス / 感染症診断学 / heterogeneity / 電子顕微鏡 / モルフォメトリー / 部分肝切除 / 肝再生 / ビタミンA / 星細胞 / 肝臓 … More
Except Principal Investigator
肝臓星細胞 / グリーンランド / コラーゲン / 肝臓 / 星細胞 / ビタミンA / Signal transport / Collagen / Gene expression / Extracellular matrix / Cell / 遺伝子発現制御 / マトリックスメタロプロテアーゼ / 細胞内シグナル伝達 / インテグリン / PCR-differential display / I型コラーゲン / シグナル伝達 / 発現制御 / 細胞外マトリックス / 細胞 / autofluorescence / gold chloride / lipid droplet / food web / hepatic stellate cell / vitamin A / polar bears / Greenland / 臓器障害 / 環境汚染物質 / PCB / ダイオキシン / 自家蛍光 / 塩化金 / 脂質滴 / 食物連鎖 / ホッキョクグマ / liver diverticulun / clone / foregut / septum transversum / liver bud / stem cell / liver / stellate cell / 間葉系細胞 / ビタミンA貯蔵細胞 / 分化 / 肝憩室 / クローン / 前腸 / 横中隔 / 肝芽 / 幹細胞 / 食物 / 自然環境 / 脂質代謝関連遺伝子 / 結腸がん / モンゴロイド / 脂肪 / イヌイット / アポトーシス / 線維化 / 高速液クロ / ヤツメウナギ / 胆汁 / 毛細胆管 / 微細形態 / コレステロール / 胆汁酸 / 胆道閉鎖症 / ヤツメナギ / 遺伝要因 / ノルウエー人 / 肺がん / 遺伝子 / 脂質 / 大腸がん / サーメ人 / 脂質関連がん Less
  • Research Projects

    (10 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (15 People)
  •  Does cccDNA depletion by complete blockage of HBV replication result in a cure for hepatitis B? -Elucidation using PXB mice model-Principal Investigator

    • Principal Investigator
      鍬田 伸好 (東伸好)
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      National Center for Global Health and Medicine
  •  Evaluation of cellular senescence associated with HBV infection and the effect of anti-HBV nucleic acid analogPrincipal Investigator

    • Principal Investigator
      Higashi-Kuwata Nobuyo
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      National Center for Global Health and Medicine
  •  Altered dynamics of HIVmCherry dissemination in huPBMC-transplanted NOJmice under anti-HIV drug administratioPrincipal Investigator

    • Principal Investigator
      KUWATA Nobuyo
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Infectious disease medicine
    • Research Institution
      Kumamoto University
  •  北欧極北民族における脂質関連がんの発生と環境・宿主要因の解明

    • Principal Investigator
      妹尾 春樹
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Akita University
  •  肝再生時に星細胞が果たす役割の解明Principal Investigator

    • Principal Investigator
      東 伸好
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General anatomy (including Histology/Embryology)
    • Research Institution
      Akita University
  •  Gene regulation by 3-D structure of extracellular matrix : a model for hepatic stellate cells

    • Principal Investigator
      IRIE Toshiaki, 佐藤 充
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General anatomy (including Histology/Embryology)
    • Research Institution
      Hokkaido National College of Technology
      Akita University
  •  北欧極北民族における脂質関連がんの発生と環境・宿主要因の解明

    • Principal Investigator
      SENOO Haruki
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Akita University
  •  胆汁成分の新規処理機構の解明-胆道閉鎖症治療への応用を目指して-

    • Principal Investigator
      妹尾 春樹
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pediatric surgery
    • Research Institution
      Akita University
  •  A study on vitamin A storage in polar bears in Greenland.

    • Principal Investigator
      SENOO Haruki
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental physiology (including Physical medicine and Nutritional physiology)
    • Research Institution
      Akita University
  •  a study on isolation and clonal expansion of the stem cell of hepatic stellate cells.

    • Principal Investigator
      SENOO Haruki
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General anatomy (including Histology/Embryology)
    • Research Institution
      Akita University

All 2023 2020 2012 2005 2004 2003 Other

All Journal Article Presentation

  • [Journal Article] Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV2020

    • Author(s)
      Higashi-Kuwata Nobuyo、Hayashi Sanae、Kumamoto Hiroki、Ogata-Aoki Hiromi、Das Debananda、Venzon David、Hattori Shin-ichiro、Bulut Haydar、Hashimoto Mai、Otagiri Masaki、Takamune Nobutoki、Kishimoto Naoki、Davis David A.、Misumi Shogo、Kakuni Masakazu、Tanaka Yasuhito、Mitsuya Hiroaki
    • Journal Title

      Journal of Hepatology

      Volume: 15 Issue: 5 Pages: 33843-5

    • DOI

      10.1016/j.jhep.2020.12.006

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K16996, KAKENHI-PROJECT-18K08460
  • [Journal Article] Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.2005

    • Author(s)
      Higashi N, Wake K, Sato M, Kojima N, Imai K, Senoo H.
    • Journal Title

      Anatomical Record Part A 285(1)

      Pages: 668-675

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590133
  • [Journal Article] Vitamin A storage in hepatic stellate cells in the regenerating rat liver --with special reference to zonal heterogeneity--2005

    • Author(s)
      Higashi, N
    • Journal Title

      Anat Rec, 286A

      Pages: 899-907

    • Data Source
      KAKENHI-PROJECT-15659418
  • [Journal Article] Vitamin A storage in hepatic stellate cells in the regenerating rat liver - with special reference to zonal heterogeneity -2005

    • Author(s)
      Higashi N., Sato M., Kojima, N., Irie, T., Kawamura, K., Mabuchi, A., Senoo, H.
    • Journal Title

      Anatomical Record Part A 286(2)

      Pages: 899-907

    • Data Source
      KAKENHI-PROJECT-16590133
  • [Journal Article] Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.2005

    • Author(s)
      Higashi, N., Wake, K., Sato, M., Kojima, N., Imai, K., Senoo, H.
    • Journal Title

      Anat.Rec.Part A 285(1)

      Pages: 668-675

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590133
  • [Journal Article] Vitamin A storage in hepatic stellate cells in the regenerating rat liver : with special reference to zonal heterogeneity.2005

    • Author(s)
      Higashi, N., Sato, M., Kojima, N., Irie, T., Kawamura, K., Mabuchi, A., Senoo, H.
    • Journal Title

      Anat.Rec.Part A 286(2)

      Pages: 899-907

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590133
  • [Journal Article] Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.2005

    • Author(s)
      Higashi, N
    • Journal Title

      Anat Rec, 285A

      Pages: 668-675

    • Data Source
      KAKENHI-PROJECT-15659418
  • [Journal Article] Vitamin A storage in hepatic stellate cells in the regenerating rat liver-with special reference to zonal heterogeneity-2005

    • Author(s)
      Higashi, N., Sato, M., Kojima, N., Irie, T., Kawamura, K., Mabuchi, A., Senoo, H.
    • Journal Title

      Anatomical Record Part A 286(2)

      Pages: 899-907

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590133
  • [Journal Article] Cell-cell junctions between mammalian (human and rat) hepatic stellate cells.2004

    • Author(s)
      Higashi, N.
    • Journal Title

      Cell Tiss Res 317

      Pages: 35-43

    • Data Source
      KAKENHI-PROJECT-15659418
  • [Journal Article] Cell-cell junctions between mammalian (human and rat) hepatic stellate cells.2004

    • Author(s)
      Higashi, N., Kojima, N., Miura, M., Imai, K., Sato, M., Senoo, H.
    • Journal Title

      Cell and Tissue Research 317(1)

      Pages: 35-43

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590133
  • [Journal Article] Decreased capacity for vitamin A storage in hepatic stellate cells in arctic animals.2004

    • Author(s)
      Senoo, H., Wake, K., Wold, H.L., Higashi, N., Imai, K., Moskaug, J.O., Kojima, N., Miura, M., Sato, T., Sato, M., Roos, N., Berg, T., Norum, K.R., Blomhoff, R.
    • Journal Title

      Comp.Hepatol. 3(Suppl 1)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14406001
  • [Journal Article] Vitamin A distribution and content in tissues of the lamprey (Lampetra japonica).2004

    • Author(s)
      Wold, H.L., Wake, K., Higashi, N., Wang, D-R., Kojima, N., Imai, K., Blomhoff, R., Senoo, H
    • Journal Title

      Anat.Rec. 276A

      Pages: 134-142

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14406001
  • [Journal Article] Intralobular distribution of vitamin A-storing lipid droplets in hepatic stellate cells with special reference to polar bear and arctic fox.2004

    • Author(s)
      Higashi, N., Imai, K., Sato, M., Sato, T., Kojima, N., Miura, M., Wold, H.L., Moskaug, J.O., Berg, T., Norum, K.R., Roos, N., Wake, K., Blomhoff, R., Senoo, H.
    • Journal Title

      Comp.Hepatol. 3(Suppl 1)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14406001
  • [Journal Article] Intralobular distribution of vitamin A-storing lipid droplets in hepatic stellate cells with special reference to polar bear and arctic fox.2004

    • Author(s)
      Higashi, N.
    • Journal Title

      Comp Hepatol 3(Suppl 1)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14406001
  • [Journal Article] Cell-cell junctions between mammalian (human and rat) hepatic stellate cells.2004

    • Author(s)
      Higashi, N., Kojima, N., Miura, M., Imai, K., Sato, M., Senoo, H.
    • Journal Title

      Cell Tissue Res. 317(1)

      Pages: 35-43

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590133
  • [Journal Article] Cell-cell junctions between mammalian (human and rat) hepatic stellate cells.2004

    • Author(s)
      Higashi, N.
    • Journal Title

      Cell Tiss Res 317

      Pages: 35-43

    • Data Source
      KAKENHI-PROJECT-13470001
  • [Journal Article] Cell-cell junctions between mammalian (human and rat) hepatic stellate cells2004

    • Author(s)
      Higashi N et al.
    • Journal Title

      Cell and Tissue Reasearch 317

      Pages: 35-43

    • Data Source
      KAKENHI-PROJECT-16590133
  • [Journal Article] Vitamin A distribution and content in tissues of the lamprey (Lampetra japonica).2004

    • Author(s)
      Wold, H.L., Wake, K., Higashi, N., Wang, D-R., Kojima, N., Imai, K., Blomhoff, R., Senoo, H.
    • Journal Title

      Anat Rec 276A

      Pages: 134-142

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13470001
  • [Journal Article] Distribution of vitamin A-storing lipid droplets in hepatic stellate cells in liver lobules-A comparative study-.2003

    • Author(s)
      Higashi, N.
    • Journal Title

      Anat Rec 271A

      Pages: 240-248

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14406001
  • [Journal Article] Distribution of vitamin A-storing lipid droplets in hepatic stellate cells in liver lobules-A comparative study-.2003

    • Author(s)
      Higashi, N., Senoo, H.
    • Journal Title

      Anat.Rec., 271A

      Pages: 240-248

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14406001
  • [Journal Article] Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.

    • Author(s)
      Higashi, N.
    • Journal Title

      Anat Rec (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14406001
  • [Journal Article] Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.

    • Author(s)
      Higashi, N, Wake, K., Sato, M., Kojima, N., Imai, K., Senoo, H.
    • Journal Title

      Anat.Rec. (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14406001
  • [Journal Article] Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.

    • Author(s)
      Higashi, N
    • Journal Title

      Anat Rec (In press)

    • Data Source
      KAKENHI-PROJECT-14406001
  • [Journal Article] Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.

    • Author(s)
      Higashi, N
    • Journal Title

      Anat Rec (In press)

    • Data Source
      KAKENHI-PROJECT-15659418
  • [Presentation] 新規核酸系抗HBV化合物, E-CFCP,によるcccDNAの減衰/枯渇効果の検討2023

    • Author(s)
      鍬田伸好, 林佐奈衣,熊本浩樹,青木宏美, 井本修平,田中靖人,満屋裕明
    • Organizer
      第31回日本抗ウイルス療法学会学術集会・総会
    • Data Source
      KAKENHI-PROJECT-23K27645
  • [Presentation] 抗 HIV 剤 raltegravir によるHIV 体内播種早期ダイナミクスの変容2012

    • Author(s)
      鍬田伸好
    • Organizer
      第26回日本エイズ学会
    • Place of Presentation
      慶応義塾大学日吉キャンパス(神奈川県)
    • Year and Date
      2012-11-25
    • Data Source
      KAKENHI-PROJECT-24659483
  • [Presentation] Altereddynamics of HIVmCdissemination inhuPBMC-transplanted NOJ mice underRaltegravir administration2012

    • Author(s)
      Nobuyo Higashi-Kuwata
    • Organizer
      the 13thKumamoto AIDS Seminar
    • Place of Presentation
      Aso Resort Grandvrion Hotel(Kumamoto)
    • Year and Date
      2012-10-25
    • Data Source
      KAKENHI-PROJECT-24659483
  • [Presentation] 抗 HIV剤 raltegravir によるHIV体内播種早期ダイナミクスの変容2012

    • Author(s)
      鍬田伸好
    • Organizer
      第26回日本エイズ学会
    • Place of Presentation
      慶応義塾大学日吉キャンパス(神奈川県)
    • Data Source
      KAKENHI-PROJECT-24659483
  • [Presentation] 抗 HIV 剤による HIV 体内播種早期ダイナミクスの変容2012

    • Author(s)
      鍬田伸好
    • Organizer
      白馬シンポジウム
    • Place of Presentation
      京都市国際交流会館(京都府)
    • Year and Date
      2012-06-07
    • Data Source
      KAKENHI-PROJECT-24659483
  • [Presentation] Altered dynamics of HIVmC dissemination in huPBMC-transplanted NOJ mice under Raltegravir administration2012

    • Author(s)
      Nobuyo Higashi-Kuwata
    • Organizer
      The13th Kumamoto AIDS Seminar
    • Place of Presentation
      Aso Resort Grandvrion Hotel (Kumamoto)
    • Data Source
      KAKENHI-PROJECT-24659483
  • [Presentation] 抗 HIV剤によるHIV体内播種早期ダイナミクスの変容2012

    • Author(s)
      鍬田伸好
    • Organizer
      第14回白馬シンポジウム
    • Place of Presentation
      京都市国際交流会館 (京都府)
    • Data Source
      KAKENHI-PROJECT-24659483
  • 1.  SENOO Haruki (90171355)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 13 results
  • 2.  SATO Mitsuru (60226008)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 10 results
  • 3.  IRIE Toshiaki (90231167)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 3 results
  • 4.  佐藤 岳哉 (10312696)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 5.  YOSHIKAWA Kiwamu (90400481)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  上島 弘嗣 (70144483)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  今井 克幸 (80006741)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 8.  青木 宏美 (90970351)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 9.  江口 秀孝 (00260232)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  加藤 哲夫 (20004963)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  萱場 広之 (70224706)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  吉野 裕顕 (90182807)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  伊藤 正毅 (40126389)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  林 佐奈衣 (10597587)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 15.  熊本 浩樹 (80297019)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

URL: 

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi