KUWATA NOBUYO 鍬田伸好 (東伸好)

… Alternative Names

東伸好

Higashi-Kuwata Nobuyo 鍬田伸好

KUWATA Nobuyo 鍬田伸好

鍬田伸好(東伸好) クワタノブヨ

HIGASHI Nobuyo 東伸好

Less

Researcher Number	60361218
Other IDs	https://orcid.org/0000-0002-9404-3532
External Links
Affiliation (Current)	2025: 国立研究開発法人国立国際医療研究センター, 研究所, 難治性ウイルス感染症研究部室長
Affiliation (based on the past Project Information) *help	2023 – 2024: 国立研究開発法人国立国際医療研究センター, その他部局等, 研究所難治性ウイルス感染症研究部室長 2020: 国立研究開発法人国立国際医療研究センター, その他部局等, 研究所難治性ウイルス感染症研究部主任研究員 2019: 国立研究開発法人国立国際医療研究センター, 研究所難治性ウイルス感染症研究部, 主任研究員 2018: 国立研究開発法人国立国際医療研究センター, その他部局等, 主任研究員 2012: 熊本大学, エイズ学研究センター, 特任助教 2005: 秋田大, 医学部, 助手 2003 – 2004: 秋田大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Infectious disease medicine / General anatomy (including Histology/Embryology) Except Principal Investigator Biological Sciences / General anatomy (including Histology/Embryology) / Environmental physiology (including Physical medicine and Nutritional physiology) / General anatomy (including Histology/Embryology) / Pediatric surgery
Keywords	Principal Investigator 新規核酸系抗HBV化合物 / HBV / B型慢性肝炎 / cccDNA / ヒト肝キメラマウス / 抗ウイルス薬開発 / ヒトB型肝炎ウイルス / HBV感染症 / SASP / テロメア長 … More / p16 / 老化関連β-ガラクトシダーゼ / 抗HBV核酸アナログ / 細胞老化 / p21 / 老化関連βガラクトシダーゼ / 抗HBV核酸アナログと細胞老化細胞老化 / 抗HBV核酸アナログと細胞老化 / HBV感染と細胞老化 / HBV感染 / Raltegravir / 抗HIV薬 / in vivo imaging / AIDS / HIVmCherry / humanized マウス / 感染症診断学 / heterogeneity / 電子顕微鏡 / モルフォメトリー / 部分肝切除 / 肝再生 / ビタミンA / 星細胞 / 肝臓 … More Except Principal Investigator 肝臓星細胞 / グリーンランド / コラーゲン / 肝臓 / 星細胞 / ビタミンA / Signal transport / Collagen / Gene expression / Extracellular matrix / Cell / 遺伝子発現制御 / マトリックスメタロプロテアーゼ / 細胞内シグナル伝達 / インテグリン / PCR-differential display / I型コラーゲン / シグナル伝達 / 発現制御 / 細胞外マトリックス / 細胞 / autofluorescence / gold chloride / lipid droplet / food web / hepatic stellate cell / vitamin A / polar bears / Greenland / 臓器障害 / 環境汚染物質 / PCB / ダイオキシン / 自家蛍光 / 塩化金 / 脂質滴 / 食物連鎖 / ホッキョクグマ / liver diverticulun / clone / foregut / septum transversum / liver bud / stem cell / liver / stellate cell / 間葉系細胞 / ビタミンA貯蔵細胞 / 分化 / 肝憩室 / クローン / 前腸 / 横中隔 / 肝芽 / 幹細胞 / 食物 / 自然環境 / 脂質代謝関連遺伝子 / 結腸がん / モンゴロイド / 脂肪 / イヌイット / アポトーシス / 線維化 / 高速液クロ / ヤツメウナギ / 胆汁 / 毛細胆管 / 微細形態 / コレステロール / 胆汁酸 / 胆道閉鎖症 / ヤツメナギ / 遺伝要因 / ノルウエー人 / 肺がん / 遺伝子 / 脂質 / 大腸がん / サーメ人 / 脂質関連がん Less

Does cccDNA depletion by complete blockage of HBV replication result in a cure for hepatitis B? -Elucidation using PXB mice model-Principal Investigator
- Principal Investigator
  
  鍬田伸好 (東伸好)
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Center for Global Health and Medicine
Evaluation of cellular senescence associated with HBV infection and the effect of anti-HBV nucleic acid analogPrincipal Investigator
- Principal Investigator
  
  Higashi-Kuwata Nobuyo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Center for Global Health and Medicine
Altered dynamics of HIVmCherry dissemination in huPBMC-transplanted NOJmice under anti-HIV drug administratioPrincipal Investigator
- Principal Investigator
  
  KUWATA Nobuyo
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
北欧極北民族における脂質関連がんの発生と環境・宿主要因の解明
- Principal Investigator
  
  妹尾春樹
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Akita University
肝再生時に星細胞が果たす役割の解明Principal Investigator
- Principal Investigator
  
  東伸好
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Akita University
Gene regulation by 3-D structure of extracellular matrix : a model for hepatic stellate cells
- Principal Investigator
  
  IRIE Toshiaki, 佐藤充
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Hokkaido National College of Technology
  Akita University
北欧極北民族における脂質関連がんの発生と環境・宿主要因の解明
- Principal Investigator
  
  SENOO Haruki
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Akita University
胆汁成分の新規処理機構の解明-胆道閉鎖症治療への応用を目指して-
- Principal Investigator
  
  妹尾春樹
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatric surgery
- Research Institution
  Akita University
A study on vitamin A storage in polar bears in Greenland.
- Principal Investigator
  
  SENOO Haruki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Akita University
a study on isolation and clonal expansion of the stem cell of hepatic stellate cells.
- Principal Investigator
  
  SENOO Haruki
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Akita University

All 2023 2020 2012 2005 2004 2003 Other

All Journal Article Presentation

[Journal Article] Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV2020
- Author(s)
  Higashi-Kuwata Nobuyo、Hayashi Sanae、Kumamoto Hiroki、Ogata-Aoki Hiromi、Das Debananda、Venzon David、Hattori Shin-ichiro、Bulut Haydar、Hashimoto Mai、Otagiri Masaki、Takamune Nobutoki、Kishimoto Naoki、Davis David A.、Misumi Shogo、Kakuni Masakazu、Tanaka Yasuhito、Mitsuya Hiroaki
- Journal Title
  
  Journal of Hepatology
  
  Volume: 15 Issue: 5 Pages: 33843-5
- DOI
  10.1016/j.jhep.2020.12.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16996, KAKENHI-PROJECT-18K08460
[Journal Article] Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.2005
- Author(s)
  Higashi N, Wake K, Sato M, Kojima N, Imai K, Senoo H.
- Journal Title
  
  Anatomical Record Part A 285(1)
  
  Pages: 668-675
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590133
[Journal Article] Vitamin A storage in hepatic stellate cells in the regenerating rat liver --with special reference to zonal heterogeneity--2005
- Author(s)
  Higashi, N
- Journal Title
  
  Anat Rec, 286A
  
  Pages: 899-907
- Data Source
  KAKENHI-PROJECT-15659418
[Journal Article] Vitamin A storage in hepatic stellate cells in the regenerating rat liver - with special reference to zonal heterogeneity -2005
- Author(s)
  Higashi N., Sato M., Kojima, N., Irie, T., Kawamura, K., Mabuchi, A., Senoo, H.
- Journal Title
  
  Anatomical Record Part A 286(2)
  
  Pages: 899-907
- Data Source
  KAKENHI-PROJECT-16590133
[Journal Article] Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.2005
- Author(s)
  Higashi, N., Wake, K., Sato, M., Kojima, N., Imai, K., Senoo, H.
- Journal Title
  
  Anat.Rec.Part A 285(1)
  
  Pages: 668-675
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590133
[Journal Article] Vitamin A storage in hepatic stellate cells in the regenerating rat liver : with special reference to zonal heterogeneity.2005
- Author(s)
  Higashi, N., Sato, M., Kojima, N., Irie, T., Kawamura, K., Mabuchi, A., Senoo, H.
- Journal Title
  
  Anat.Rec.Part A 286(2)
  
  Pages: 899-907
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590133
[Journal Article] Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.2005
- Author(s)
  Higashi, N
- Journal Title
  
  Anat Rec, 285A
  
  Pages: 668-675
- Data Source
  KAKENHI-PROJECT-15659418
[Journal Article] Vitamin A storage in hepatic stellate cells in the regenerating rat liver-with special reference to zonal heterogeneity-2005
- Author(s)
  Higashi, N., Sato, M., Kojima, N., Irie, T., Kawamura, K., Mabuchi, A., Senoo, H.
- Journal Title
  
  Anatomical Record Part A 286(2)
  
  Pages: 899-907
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590133
[Journal Article] Cell-cell junctions between mammalian (human and rat) hepatic stellate cells.2004
- Author(s)
  Higashi, N.
- Journal Title
  
  Cell Tiss Res 317
  
  Pages: 35-43
- Data Source
  KAKENHI-PROJECT-15659418
[Journal Article] Cell-cell junctions between mammalian (human and rat) hepatic stellate cells.2004
- Author(s)
  Higashi, N., Kojima, N., Miura, M., Imai, K., Sato, M., Senoo, H.
- Journal Title
  
  Cell and Tissue Research 317(1)
  
  Pages: 35-43
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590133
[Journal Article] Decreased capacity for vitamin A storage in hepatic stellate cells in arctic animals.2004
- Author(s)
  Senoo, H., Wake, K., Wold, H.L., Higashi, N., Imai, K., Moskaug, J.O., Kojima, N., Miura, M., Sato, T., Sato, M., Roos, N., Berg, T., Norum, K.R., Blomhoff, R.
- Journal Title
  
  Comp.Hepatol. 3(Suppl 1)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14406001
[Journal Article] Vitamin A distribution and content in tissues of the lamprey (Lampetra japonica).2004
- Author(s)
  Wold, H.L., Wake, K., Higashi, N., Wang, D-R., Kojima, N., Imai, K., Blomhoff, R., Senoo, H
- Journal Title
  
  Anat.Rec. 276A
  
  Pages: 134-142
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14406001
[Journal Article] Intralobular distribution of vitamin A-storing lipid droplets in hepatic stellate cells with special reference to polar bear and arctic fox.2004
- Author(s)
  Higashi, N., Imai, K., Sato, M., Sato, T., Kojima, N., Miura, M., Wold, H.L., Moskaug, J.O., Berg, T., Norum, K.R., Roos, N., Wake, K., Blomhoff, R., Senoo, H.
- Journal Title
  
  Comp.Hepatol. 3(Suppl 1)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14406001
[Journal Article] Intralobular distribution of vitamin A-storing lipid droplets in hepatic stellate cells with special reference to polar bear and arctic fox.2004
- Author(s)
  Higashi, N.
- Journal Title
  
  Comp Hepatol 3(Suppl 1)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14406001
[Journal Article] Cell-cell junctions between mammalian (human and rat) hepatic stellate cells.2004
- Author(s)
  Higashi, N., Kojima, N., Miura, M., Imai, K., Sato, M., Senoo, H.
- Journal Title
  
  Cell Tissue Res. 317(1)
  
  Pages: 35-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590133
[Journal Article] Cell-cell junctions between mammalian (human and rat) hepatic stellate cells.2004
- Author(s)
  Higashi, N.
- Journal Title
  
  Cell Tiss Res 317
  
  Pages: 35-43
- Data Source
  KAKENHI-PROJECT-13470001
[Journal Article] Cell-cell junctions between mammalian (human and rat) hepatic stellate cells2004
- Author(s)
  Higashi N et al.
- Journal Title
  
  Cell and Tissue Reasearch 317
  
  Pages: 35-43
- Data Source
  KAKENHI-PROJECT-16590133
[Journal Article] Vitamin A distribution and content in tissues of the lamprey (Lampetra japonica).2004
- Author(s)
  Wold, H.L., Wake, K., Higashi, N., Wang, D-R., Kojima, N., Imai, K., Blomhoff, R., Senoo, H.
- Journal Title
  
  Anat Rec 276A
  
  Pages: 134-142
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13470001
[Journal Article] Distribution of vitamin A-storing lipid droplets in hepatic stellate cells in liver lobules-A comparative study-.2003
- Author(s)
  Higashi, N.
- Journal Title
  
  Anat Rec 271A
  
  Pages: 240-248
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14406001
[Journal Article] Distribution of vitamin A-storing lipid droplets in hepatic stellate cells in liver lobules-A comparative study-.2003
- Author(s)
  Higashi, N., Senoo, H.
- Journal Title
  
  Anat.Rec., 271A
  
  Pages: 240-248
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14406001
[Journal Article] Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.
- Author(s)
  Higashi, N.
- Journal Title
  
  Anat Rec (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14406001
[Journal Article] Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.
- Author(s)
  Higashi, N, Wake, K., Sato, M., Kojima, N., Imai, K., Senoo, H.
- Journal Title
  
  Anat.Rec. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14406001
[Journal Article] Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.
- Author(s)
  Higashi, N
- Journal Title
  
  Anat Rec (In press)
- Data Source
  KAKENHI-PROJECT-14406001
[Journal Article] Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.
- Author(s)
  Higashi, N
- Journal Title
  
  Anat Rec (In press)
- Data Source
  KAKENHI-PROJECT-15659418
[Presentation] 新規核酸系抗HBV化合物, E-CFCP,によるcccDNAの減衰/枯渇効果の検討2023
- Author(s)
  鍬田伸好, 林佐奈衣,熊本浩樹,青木宏美, 井本修平,田中靖人,満屋裕明
- Organizer
  第31回日本抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-23K27645
[Presentation] 抗 HIV 剤 raltegravir によるHIV 体内播種早期ダイナミクスの変容2012
- Author(s)
  鍬田伸好
- Organizer
  第26回日本エイズ学会
- Place of Presentation
  慶応義塾大学日吉キャンパス(神奈川県)
- Year and Date
  2012-11-25
- Data Source
  KAKENHI-PROJECT-24659483
[Presentation] Altereddynamics of HIVmCdissemination inhuPBMC-transplanted NOJ mice underRaltegravir administration2012
- Author(s)
  Nobuyo Higashi-Kuwata
- Organizer
  the 13thKumamoto AIDS Seminar
- Place of Presentation
  Aso Resort Grandvrion Hotel(Kumamoto)
- Year and Date
  2012-10-25
- Data Source
  KAKENHI-PROJECT-24659483
[Presentation] 抗 HIV剤 raltegravir によるHIV体内播種早期ダイナミクスの変容2012
- Author(s)
  鍬田伸好
- Organizer
  第26回日本エイズ学会
- Place of Presentation
  慶応義塾大学日吉キャンパス(神奈川県)
- Data Source
  KAKENHI-PROJECT-24659483
[Presentation] 抗 HIV 剤による HIV 体内播種早期ダイナミクスの変容2012
- Author(s)
  鍬田伸好
- Organizer
  白馬シンポジウム
- Place of Presentation
  京都市国際交流会館(京都府)
- Year and Date
  2012-06-07
- Data Source
  KAKENHI-PROJECT-24659483
[Presentation] Altered dynamics of HIVmC dissemination in huPBMC-transplanted NOJ mice under Raltegravir administration2012
- Author(s)
  Nobuyo Higashi-Kuwata
- Organizer
  The13th Kumamoto AIDS Seminar
- Place of Presentation
  Aso Resort Grandvrion Hotel (Kumamoto)
- Data Source
  KAKENHI-PROJECT-24659483
[Presentation] 抗 HIV剤によるHIV体内播種早期ダイナミクスの変容2012
- Author(s)
  鍬田伸好
- Organizer
  第14回白馬シンポジウム
- Place of Presentation
  京都市国際交流会館 (京都府)
- Data Source
  KAKENHI-PROJECT-24659483

1. SENOO Haruki (90171355)

# of Collaborated Projects: 6 results

# of Collaborated Products: 13 results
2. SATO Mitsuru (60226008)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
3. IRIE Toshiaki (90231167)

# of Collaborated Projects: 6 results

# of Collaborated Products: 3 results
4. 佐藤岳哉 (10312696)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
5. YOSHIKAWA Kiwamu (90400481)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 上島弘嗣 (70144483)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 今井克幸 (80006741)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
8. 青木宏美 (90970351)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 江口秀孝 (00260232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 加藤哲夫 (20004963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 萱場広之 (70224706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 吉野裕顕 (90182807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 伊藤正毅 (40126389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 林佐奈衣 (10597587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 熊本浩樹 (80297019)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

KUWATA NOBUYO 鍬田 伸好 (東 伸好)

東伸好

Higashi-Kuwata Nobuyo 鍬田 伸好

KUWATA Nobuyo 鍬田 伸好

鍬田 伸好(東伸好) クワタ ノブヨ

HIGASHI Nobuyo 東 伸好

Research Projects

Research Products

Co-Researchers

Does cccDNA depletion by complete blockage of HBV replication result in a cure for hepatitis B? -Elucidation using PXB mice model-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of cellular senescence associated with HBV infection and the effect of anti-HBV nucleic acid analogPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Altered dynamics of HIVmCherry dissemination in huPBMC-transplanted NOJmice under anti-HIV drug administratioPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

北欧極北民族における脂質関連がんの発生と環境・宿主要因の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肝再生時に星細胞が果たす役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene regulation by 3-D structure of extracellular matrix : a model for hepatic stellate cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

北欧極北民族における脂質関連がんの発生と環境・宿主要因の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

胆汁成分の新規処理機構の解明-胆道閉鎖症治療への応用を目指して-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on vitamin A storage in polar bears in Greenland.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

a study on isolation and clonal expansion of the stem cell of hepatic stellate cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV2020

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[Journal Article] Degradation of extracellular matrix by extrahepatic stellate cells in the intestine of the lamprey, Lampetra japonica.2005

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[Journal Article] Vitamin A storage in hepatic stellate cells in the regenerating rat liver --with special reference to zonal heterogeneity--2005

KUWATA NOBUYO 鍬田伸好 (東伸好)

Higashi-Kuwata Nobuyo 鍬田伸好

KUWATA Nobuyo 鍬田伸好

鍬田伸好(東伸好) クワタノブヨ

HIGASHI Nobuyo 東伸好